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Ryan Sartor

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Living Beings

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Intestinal Mucosa

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Natalie Steck; Susan L Tonkonogy; Roger Vogelmann; Hannes Hahne; Micha Hoffmann; Sandra C Kim; Dagmar Krueger; Bernhard Kuster; Katrin Mair; Mihaela Pruteanu; Ryan Sartor; Irina G Sava; Michael Schemann; Fergus Shanahan; Dirk Haller
Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation.
Bo Liu; Susan L Tonkonogy; Ryan Sartor
Antigen-presenting cell production of IL-10 inhibits T-helper 1 and 17 cell responses and suppresses colitis in mice.
Ryan Sartor
Key questions to guide a better understanding of host-commensal microbiota interactions in intestinal inflammation.

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All Publications

2011: Natalie Steck; Susan L Tonkonogy; Roger Vogelmann; Hannes Hahne; Micha Hoffmann; Sandra C Kim; Dagmar Krueger; Bernhard Kuster; Katrin Mair; Mihaela Pruteanu; Ryan Sartor; Irina G Sava; Michael Schemann; Fergus Shanahan; Dirk Haller
Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation.
Gastroenterology 2011;141(3):959-71.
2011: Bo Liu; Susan L Tonkonogy; Ryan Sartor
Antigen-presenting cell production of IL-10 inhibits T-helper 1 and 17 cell responses and suppresses colitis in mice.
Gastroenterology 2011;141(2):653-62, 662.e1-4.
2011: Ryan Sartor
Key questions to guide a better understanding of host-commensal microbiota interactions in intestinal inflammation.
Mucosal immunology 2011;4(2):127-32.
2010: S W Pawlowski; G Calabrese; G L Kolling; J Platts-Mills; R Freire; C AlcantaraWarren; B Liu; Ryan Sartor; R L Guerrant
Murine model of Clostridium difficile infection with aged gnotobiotic C57BL/6 mice and a BI/NAP1 strain.
The Journal of infectious diseases 2010;202(11):1708-12.
2009: J S Kim; Hongyu An; W J Rieter; Denise Esserman; K M L Taylor-Pashow; Ryan Sartor; Weili Lin; Wenbin Lin; Teresa Tarrant
Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis.
Clinical and experimental rheumatology 2009;27(4):580-6.
2009: James P Moran; Jens Walter; Gerald W Tannock; Susan L Tonkonogy; Ryan Sartor
Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-10-deficient mice.
Inflammatory bowel diseases 2009;15(7):1022-31.
2009: Christopher D Packey; Ryan Sartor
Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases.
Current opinion in infectious diseases 2009;22(3):292-301.
2009: Jonathan Hansen; Lisa Holt; Ryan Sartor
Gene expression patterns in experimental colitis in IL-10-deficient mice.
Inflammatory bowel diseases 2009;15(6):890-9.
2009: Ki-Jong Rhee; Shaoguang Wu; Xinqun Wu; David L Huso; Baktiar O Karim; Augusto A. Franco-Mora; Shervin Rabizadeh; Jonathan E Golub; Lauren E Mathews; Jai Shin; Ryan Sartor; Douglas Golenbock; Abdel Rahim A Hamad; Christine M Gan; Franck Housseau; Cynthia L Sears
Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.
Infection and immunity 2009;77(4):1708-18.
2009: Carol A Albright; Ryan Sartor; Susan L Tonkonogy
Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria.
Immunology letters 2009;123(1):77-87.
2009: Micha Hoffmann; Sandra Kim; Ryan Sartor; Dirk Haller
Enterococcus faecalis strains differentially regulate Alix/AIP1 protein expression and ERK 1/2 activation in intestinal epithelial cells in the context of chronic experimental colitis.
Journal of proteome research 2009;8(3):1183-92.
2009: Kristen L W Walton; Lisa Holt; Ryan Sartor
Lipopolysaccharide activates innate immune responses in murine intestinal myofibroblasts through multiple signaling pathways.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(3):G601-11.
2009: Ryan Sartor
Microbial-host interactions in inflammatory bowel diseases and experimental colitis.
Nestlé Nutrition workshop series. Paediatric programme 2009;64():121-32; discussion 132-7, 251-7.
2008: Claire B Larmonier; J K Uno; Kang-Moon Lee; T Karrasch; D Laubitz; R Thurston; M T Midura-Kiela; Fayez K Ghishan; Ryan Sartor; Christian Jobin; Pawel Kiela
Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(5):G1079-91.
2008: Ryan Sartor
Therapeutic correction of bacterial dysbiosis discovered by molecular techniques.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16413-4.
2008: Ivaylo I Ivanov; Rosa de Llanos Frutos; Nicolas Manel; Keiji Yoshinaga; Daniel B Rifkin; Ryan Sartor; B Brett Finlay; Dan R Littman
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.
Cell host & microbe 2008;4(4):337-49.
2008: Bi-Feng Qian; Susan L Tonkonogy; Ryan Sartor
Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cells.
Inflammatory bowel diseases 2008;14(10):1358-65.
2008: Vishnudutt Purohit; J Christian Bode; Christiane Bode; David A Brenner; Mashkoor A Choudhry; Frank Hamilton; Y James Kang; Ali Keshavarzian; Radhakrishna Rao; Ryan Sartor; Christine Swanson; Jerrold R Turner
Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium.
Alcohol (Fayetteville, N.Y.) 2008;42(5):349-61.
2008: Bi-Feng Qian; Susan L Tonkonogy; Ryan Sartor
Reduced responsiveness of HLA-B27 transgenic rat cells to TGF-beta and IL-10-mediated regulation of IFN-gamma production.
Inflammatory bowel diseases 2008;14(7):921-30.
2008: C D Packey; Ryan Sartor
Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases.
Journal of internal medicine 2008;263(6):597-606.
2008: Nicholas J Shaheen; Ryan Sartor
Our new president--Robert S. Sandler, MD, MPH.
Gastroenterology 2008;134(5):1596-600.
2008: Peter Velázquez; Bo Wei; Michael McPherson; Lesley Marie A Mendoza; Sandra L Nguyen; Olga Turovskaya; Mitchell Kronenberg; Tiffany T Huang; Matthew Schrage; Lynn N Lobato; Daisuke Fujiwara; Sarah Brewer; Moshe Arditi; Genhong Cheng; Ryan Sartor; Rodney D Newberry; Jonathan Braun
Villous B cells of the small intestine are specialized for invariant NK T cell dependence.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4629-38.
2008: Ryan Sartor
Microbial influences in inflammatory bowel diseases.
Gastroenterology 2008;134(2):577-94.
2007: Ryan Sartor; Marcus Muehlbauer
Microbial host interactions in IBD: implications for pathogenesis and therapy.
Current gastroenterology reports 2007;9(6):497-507.
2007: Sandra Kim; Susan L Tonkonogy; Thomas Karrasch; Christian Jobin; Ryan Sartor
Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis.
Inflammatory bowel diseases 2007;13(12):1457-66.
2007: Di Meng; David S Newburg; Cheryl Young; Amy Baker; Susan L Tonkonogy; Ryan Sartor; W Allan Walker; N Nanda Nanthakumar
Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(4):G780-7.
2007: Sarmina Hassan; Irma M Sainz; Mohammad M Khan; Harlan N Bradford; Irma Isordia-Salas; Sakeen W Kashem; Ryan Sartor; Robert W Colman
Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo.
American journal of physiology. Heart and circulatory physiology 2007;292(6):H2959-65.
2007: Ryan Sartor; Richard S Blumberg; Jonathan Braun; Charles O Elson; Lloyd F Mayer
CCFA microbial-host interactions workshop: highlights and key observations.
Inflammatory bowel diseases 2007;13(5):600-19.
2007: Frank Hoentjen; Susan L Tonkonogy; Bi-Feng Qian; Bo Liu; Levinus A Dieleman; Ryan Sartor
CD4(+) T lymphocytes mediate colitis in HLA-B27 transgenic rats monoassociated with nonpathogenic Bacteroides vulgatus.
Inflammatory bowel diseases 2007;13(3):317-24.
2007: Anna Shkoda; Pedro A Ruiz; Hannelore Daniel; Sandra Kim; Gerhard Rogler; Ryan Sartor; Dirk Haller
Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation.
Gastroenterology 2007;132(1):190-207.
2006: Pedro A Ruiz; Anna Shkoda; Sandra Kim; Ryan Sartor; Dirk Haller
IL-10 gene-deficient mice lack TGF-beta/Smad-mediated TLR2 degradation and fail to inhibit proinflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammation.
Annals of the New York Academy of Sciences 2006;1072():389-94.
2006: Ryan Sartor
Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.
Nature clinical practice. Gastroenterology & hepatology 2006;3(7):390-407.
2006: Claudia Veltkamp; Rebecca Ruhwald; Thomas Giesem; Frank Autschbach; Ines Kaden; Roland Veltkamp; Ryan Sartor; Wolfgang Stremmel
CD4+CD25+ cell depletion from the normal CD4+ T cell pool prevents tolerance toward the intestinal flora and leads to chronic colitis in immunodeficient mice.
Inflammatory bowel diseases 2006;12(6):437-46.
2006: Frank Hoentjen; Susan L Tonkonogy; B Liu; Ryan Sartor; J D Taurog; Levinus A Dieleman
Adoptive transfer of nontransgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats.
Clinical and experimental immunology 2006;143(3):474-83.
2006: Kristen L W Walton; Jianping He; Brian L Kelsall; Ryan Sartor; Nancy C Fisher
Dendritic cells in germ-free and specific pathogen-free mice have similar phenotypes and in vitro antigen presenting function.
Immunology letters 2006;102(1):16-24.
2006: Ryan Sartor
Microbial and dietary factors in the pathogenesis of chronic, immune-mediated intestinal inflammation.
Advances in experimental medicine and biology 2006;579():35-54.
2005: Charlie Lees; Sarah Howie; Ryan Sartor; Jack Satsangi
The hedgehog signalling pathway in the gastrointestinal tract: implications for development, homeostasis, and disease.
Gastroenterology 2005;129(5):1696-710.
2005: Ryan Sartor
Are we losing control? Medical costs can no longer be ignored.
Gastroenterology 2005;129(4):1149.
2005: Bi-Feng Qian; Susan L Tonkonogy; Frank Hoentjen; Levinus A Dieleman; Ryan Sartor
Dysregulated luminal bacterial antigen-specific T-cell responses and antigen-presenting cell function in HLA-B27 transgenic rats with chronic colitis.
Immunology 2005;116(1):112-21.
2005: Irma M Sainz; Irma Isordia-Salas; Julian L Castaneda; Alexis Agelan; Bo Liu; Raul A DeLa Cadena; Robin A Pixley; Albert Adam; Ryan Sartor; Robert W Colman
Modulation of inflammation by kininogen deficiency in a rat model of inflammatory arthritis.
Arthritis and rheumatism 2005;52(8):2549-52.
2005: Arianne L Theiss; C Randall Fuller; James G Simmons; Bo Liu; Ryan Sartor; P Kay Lund
Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation.
Gastroenterology 2005;129(1):204-19.
2005: Rodrigo Bibiloni; Richard N Fedorak; Gerald W Tannock; Karen L Madsen; Paolo Gionchetti; Massimo Campieri; Claudio De Simone; Ryan Sartor
VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis.
The American journal of gastroenterology 2005;100(7):1539-46.
2005: Ryan Sartor
Does Mycobacterium avium subspecies paratuberculosis cause Crohn's disease?
Gut 2005;54(7):896-8.
2005: Sandra Kim; Susan L Tonkonogy; Carol A Albright; Julia Tsang; Edward Balish; Jonathon Braun; Mark M Huycke; Ryan Sartor
Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria.
Gastroenterology 2005;128(4):891-906.
2005: Ryan Sartor
Role of commensal enteric bacteria in the pathogenesis of immune-mediated intestinal inflammation: lessons from animal models and implications for translational research.
Journal of pediatric gastroenterology and nutrition 2005;40 Suppl 1():S30-1.
2005: Pedro A Ruiz; Anna Shkoda; Sandra Kim; Ryan Sartor; Dirk Haller
IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2990-9.
2005: Claudia Veltkamp; Ryan Sartor; Thomas Giese; Frank Autschbach; I Kaden; Roland Veltkamp; Daniel Rost; Birgit Kallinowski; Wolfgang Stremmel
Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGepsilon26 mice leading to the prevention of colitis.
Gut 2005;54(2):207-14.
2005: Frank Hoentjen; Ryan Sartor; Michitaka Ozaki; Christian Jobin
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.
Blood 2005;105(2):689-96.
2005: Ryan Sartor
Probiotic therapy of intestinal inflammation and infections.
Current opinion in gastroenterology 2005;21(1):44-50.
2004: Nicole M J Schwerbrock; Mireille K Makkink; Maria van der Sluis; Hans A Büller; Alexandra Einerhand; Ryan Sartor; Jan Dekker
Interleukin 10-deficient mice exhibit defective colonic Muc2 synthesis before and after induction of colitis by commensal bacteria.
Inflammatory bowel diseases 2004;10(6):811-23.
2004: Ryan Sartor
Pharmaceutical influence on clinical science and practice: a double-edged sword.
Gastroenterology 2004;127(3):703-4.
2004: Pedro A Ruiz; Sandra Kim; Ryan Sartor; Dirk Haller
15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity.
The Journal of biological chemistry 2004;279(34):36103-11.
2004: Olafur S Palsson; Olivier Morteau; Eugene M Bozymski; John T Woosley; Ryan Sartor; Michael J Davies; David A Johnson; Marsha J Turner; William E Whitehead
Elevated vasoactive intestinal peptide concentrations in patients with irritable bowel syndrome.
Digestive diseases and sciences 2004;49(7-8):1236-43.
2004: Kim L Isaacs; Ryan Sartor
Treatment of inflammatory bowel disease with antibiotics.
Gastroenterology clinics of North America 2004;33(2):335-45, x.
2004: Dirk Haller; L Holt; Alexandr Parlesak; J Zanga; A Bäuerlein; Ryan Sartor; Christian Jobin
Differential effect of immune cells on non-pathogenic Gram-negative bacteria-induced nuclear factor-kappaB activation and pro-inflammatory gene expression in intestinal epithelial cells.
Immunology 2004;112(2):310-20.
2004: Maria P Russo; Robert F Schwabe; Ryan Sartor; Christian Jobin
NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cells.
Cellular signalling 2004;16(6):741-50.
2004: Ryan Sartor
Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics.
Gastroenterology 2004;126(6):1620-33.
2004: Levinus A Dieleman; Frank Hoentjen; Bi-Feng Qian; D Sprengers; E Tjwa; M F Torres; CD Torrice; Ryan Sartor; Susan L Tonkonogy
Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats.
Clinical and experimental immunology 2004;136(1):30-9.
2004: Michael Schultz; Antje Timmer; Hans Herfarth; Ryan Sartor; Jon A Vanderhoof; Heiko C Rath
Lactobacillus GG in inducing and maintaining remission of Crohn's disease.
BMC gastroenterology 2004;4():5.
2004: Ryan Sartor
Episodic retreatment versus scheduled maintenance therapy of crohn's disease with infliximab: not so far apart.
Gastroenterology 2004;126(2):598-601.
2003: Frank Hoentjen; Hermie J M Harmsen; H Braat; CD Torrice; B A Mann; Ryan Sartor; Levinus A Dieleman
Antibiotics with a selective aerobic or anaerobic spectrum have different therapeutic activities in various regions of the colon in interleukin 10 gene deficient mice.
Gut 2003;52(12):1721-7.
2003: Irma Isordia-Salas; Robin A Pixley; Hemant Parekh; Satya P Kunapuli; Fengling Li; Antoni Stadnicki; Yingzhang Lin; Ryan Sartor; Robert W Colman
The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation.
Blood 2003;102(8):2835-42.
2003: Sean P Colgan; Richard S Pitman; Takashi Nagaishi; Atsushi Mizoguchi; Emiko Mizoguchi; Lloyd F Mayer; Ling Shao; Ryan Sartor; John R Subjeck; Richard S Blumberg
Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells.
The Journal of clinical investigation 2003;112(5):745-54.
2003: Ryan Sartor
Targeting enteric bacteria in treatment of inflammatory bowel diseases: why, how, and when.
Current opinion in gastroenterology 2003;19(4):358-65.
2003: Dirk Haller; Lisa Holt; Sandra Kim; Robert F Schwabe; Ryan Sartor; Christian Jobin
Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation.
The Journal of biological chemistry 2003;278(26):23851-60.
2003: Charles O Elson; Ryan Sartor; Stephan R Targan; William J Sandborn
Challenges in IBD Research: updating the scientific agendas.
Inflammatory bowel diseases 2003;9(3):137-53.
2003: Ryan Sartor
Translational research: Bridging the widening gap between basic and clinical research.
Gastroenterology 2003;124(5):1178.
2003: Ryan Sartor
Innate immunity in the pathogenesis and therapy of IBD.
Journal of gastroenterology 2003;38 Suppl 15():43-7.
2003: Levinus A Dieleman; M S Goerres; A Arends; D Sprengers; CD Torrice; Frank Hoentjen; Wetonia B Grenther; Ryan Sartor
Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment.
Gut 2003;52(3):370-6.
2003: Ryan Sartor
Clinical applications of advances in the genetics of IBD.
Reviews in gastroenterological disorders 2003;3 Suppl 1():S9-17.
2002: Frank Chen; Lin Ma; Ryan Sartor; Fengling Li; Huabao Xiong; An-Qiang Sun; Benjamin L Shneider
Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation.
Gastroenterology 2002;123(6):2005-16.
2002: Dirk Haller; Maria P Russo; Ryan Sartor; Christian Jobin
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines.
The Journal of biological chemistry 2002;277(41):38168-78.
2002: Michael Jeffers; William F McDonald; Rajeev A Chillakuru; Meijia Yang; Hiroshi Nakase; Lisa L Deegler; Elizabeth D Sylander; Beth Rittman; Alison Bendele; Ryan Sartor; Henri S Lichenstein
A novel human fibroblast growth factor treats experimental intestinal inflammation.
Gastroenterology 2002;123(4):1151-62.
2002: Irma Isordia-Salas; Robin A Pixley; Fengling Li; Irma M Sainz; Ryan Sartor; Albert Adam; Robert W Colman
Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(1):G180-6.
2002: Ryan Sartor
Discordant research opportunities and human resources: can we meet the challenge?
Gastroenterology 2002;122(3):603-4.
2002: Michael Schultz; Claudia Veltkamp; Levinus A Dieleman; Wetonia B Grenther; Pricilla B Wyrick; Susan L Tonkonogy; Ryan Sartor
Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice.
Inflammatory bowel diseases 2002;8(2):71-80.
2001: Ryan Sartor
Induction of mucosal immune responses by bacteria and bacterial components.
Current opinion in gastroenterology 2001;17(6):555-61.
2001: Michael Schultz; Stephen H Clarke; LW Arnold; Ryan Sartor; Susan L Tonkonogy
Disrupted B-lymphocyte development and survival in interleukin-2-deficient mice.
Immunology 2001;104(2):127-34.
2001: Ulrich Böcker; Oksana Sirenko; John S Morris; Ryan Sartor; M V Singer; J Stephen Haskill; Joanna M Watson
Expression and localization of IL-1beta mRNA is interrelated with cytoskeletal rearrangement in monocytes stimulated by adherence: a light microscopy in situ hybridization study.
Immunology and cell biology 2001;79(5):444-53.
2001: Ryan Sartor
Intestinal microflora in human and experimental inflammatory bowel disease.
Current opinion in gastroenterology 2001;17(4):324-30.
2001: Heiko C Rath; Michael Schultz; R Freitag; Levinus A Dieleman; F Li; Hans-Jörg Linde; J Schölmerich; Ryan Sartor
Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice.
Infection and immunity 2001;69(4):2277-85.
2001: Audrey B Uknis; Raul A DeLa Cadena; R Janardham; Ryan Sartor; E T Whalley; Robert W Colman
Bradykinin receptor antagonists type 2 attenuate the inflammatory changes in peptidoglycan-induced acute arthritis in the Lewis rat.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50(3):149-55.
2001: Kristen L Williams; C Randall Fuller; Levinus A Dieleman; C M DaCosta; K M Haldeman; Ryan Sartor; P Kay Lund
Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone.
Gastroenterology 2001;120(4):925-37.
2001: Claudia Veltkamp; Susan L Tonkonogy; Ype P de Jong; C Albright; Wetonia B Grenther; Edward Balish; Cox Terhorst; Ryan Sartor
Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice.
Gastroenterology 2001;120(4):900-13.
2000: Jolanta B Pucilowska; Kirk K McNaughton; NK Mohapatra; Eileen C Hoyt; Ellen M Zimmermann; Ryan Sartor; P Kay Lund
IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(6):G1307-22.
2000: H M Kandil; R A Argenzio; Ryan Sartor
Low endogenous prostaglandin E2 predisposes to relapsing inflammation in experimental rat enterocolitis.
Digestive diseases and sciences 2000;45(11):2091-9.
2000: D S Han; F Li; L Holt; K Connolly; M Hubert; R Miceli; Z Okoye; G Santiago; K Windle; E Wong; Ryan Sartor
Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(5):G1011-22.
2000: J Shao; Ryan Sartor; Elizabeth J Dial; L M Lichtenberger; W Schepp; David H Alpers
Expression of intrinsic factor in rat and murine gastric mucosal cell lineages is modified by inflammation.
The American journal of pathology 2000;157(4):1197-205.
2000: Levinus A Dieleman; A Arends; Susan L Tonkonogy; M S Goerres; D W Craft; Wetonia B Grenther; Rance K Sellon; Edward Balish; Ryan Sartor
Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice.
Infection and immunity 2000;68(9):5107-13.
2000: Christian Jobin; Ryan Sartor
NF-kappaB signaling proteins as therapeutic targets for inflammatory bowel diseases.
Inflammatory bowel diseases 2000;6(3):206-13.
2000: Ryan Sartor
Probiotics in chronic pouchitis: restoring luminal microbial balance.
Gastroenterology 2000;119(2):584-7.
2000: Ryan Sartor
New therapeutic approaches to Crohn's disease.
The New England journal of medicine 2000;342(22):1664-6.
2000: Ulrich Böcker; Arndt Schottelius; Joanna M Watson; L Holt; LL Licato; David A Brenner; Ryan Sartor; Christian Jobin
Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells.
The Journal of biological chemistry 2000;275(16):12207-13.
2000: Christian Jobin; Ryan Sartor
The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection.
American journal of physiology. Cell physiology 2000;278(3):C451-62.
2000: Olivier Morteau; Scott G Morham; Rance K Sellon; Levinus A Dieleman; Robert Langenbach; Oliver Smithies; Ryan Sartor
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.
The Journal of clinical investigation 2000;105(4):469-78.
2000: Ryan Sartor
Colitis in HLA-B27/beta 2 microglobulin transgenic rats.
International reviews of immunology 2000;19(1):39-50.
2000: Michael Schultz; Ryan Sartor
Probiotics and inflammatory bowel diseases.
The American journal of gastroenterology 2000;95(1 Suppl):S19-21.
1999: Arndt Schottelius; Marty W Mayo; Ryan Sartor; Albert S Baldwin
Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding.
The Journal of biological chemistry 1999;274(45):31868-74.
1999: H M Kandil; R A Argenzio; Ryan Sartor
Low endogenous prostaglandin E2 predisposes to relapsing inflammation in experimental rat enterocolitis.
Digestive diseases and sciences 1999;44(10):2110-8.
1999: Christian Jobin; Cynthia A Bradham; Maria P Russo; B Juma; A S Narula; David A Brenner; Ryan Sartor
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3474-83.
1999: Robert W Colman; John V White; S Scovell; Antoni Stadnicki; Ryan Sartor
Kininogens are antithrombotic proteins In vivo.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2245-50.
1999: E A van Tol; L Holt; F L Li; Fengming P Kong; Richard A Rippe; Mitsuo Yamauchi; Jolanta B Pucilowska; P Kay Lund; Ryan Sartor
Bacterial cell wall polymers promote intestinal fibrosis by direct stimulation of myofibroblasts.
The American journal of physiology 1999;277(1 Pt 1):G245-55.
1999: Michael Schultz; Susan L Tonkonogy; Rance K Sellon; Claudia Veltkamp; Virginia L Godfrey; J Kwon; Wetonia B Grenther; Edward Balish; I Horak; Ryan Sartor
IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation.
The American journal of physiology 1999;276(6 Pt 1):G1461-72.
1999: Heiko C Rath; KH Wilson; Ryan Sartor
Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli.
Infection and immunity 1999;67(6):2969-74.
1999: Christian Jobin; L Holt; Cynthia A Bradham; K Streetz; David A Brenner; Ryan Sartor
TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4447-54.
1999: Heiko C Rath; J S Ikeda; Hans-Jörg Linde; J Schölmerich; KH Wilson; Ryan Sartor
Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats.
Gastroenterology 1999;116(2):310-9.
1998: Ulrich Böcker; A Damião; L Holt; D S Han; Christian Jobin; Asit Panja; L Mayer; Ryan Sartor
Differential expression of interleukin 1 receptor antagonist isoforms in human intestinal epithelial cells.
Gastroenterology 1998;115(6):1426-38.
1998: Rance K Sellon; Susan L Tonkonogy; Michael Schultz; Levinus A Dieleman; Wetonia B Grenther; Edward Balish; D M Rennick; Ryan Sartor
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice.
Infection and immunity 1998;66(11):5224-31.
1998: Antoni Stadnicki; Julie Chao; I Stadnicka; E Van Tol; K F Lin; Fengling Li; Ryan Sartor; Robert W Colman
Localization and secretion of tissue kallikrein in peptidoglycan-induced enterocolitis in Lewis rats.
The American journal of physiology 1998;275(4 Pt 1):G854-61.
1998: Hans Herfarth; U Böcker; R Janardhanam; Ryan Sartor
Subtherapeutic corticosteroids potentiate the ability of interleukin 10 to prevent chronic inflammation in rats.
Gastroenterology 1998;115(4):856-65.
1998: M Zhou; Alain E Sayad; WA Simmons; RC Jones; SD Maika; Nimman Satumtira; Martha L Dorris; SJ Gaskell; RS Bordoli; Ryan Sartor; CA Slaughter; James A Richardson; Robert E Hammer; Joel D Taurog
The specificity of peptides bound to human histocompatibility leukocyte antigen (HLA)-B27 influences the prevalence of arthritis in HLA-B27 transgenic rats.
The Journal of experimental medicine 1998;188(5):877-86.
1998: Antoni Stadnicki; Ryan Sartor; R Janardham; I Stadnicka; AA Adam; C Blais; Robert W Colman
Kallikrein-kininogen system activation and bradykinin (B2) receptors in indomethacin induced enterocolitis in genetically susceptible Lewis rats.
Gut 1998;43(3):365-74.
1998: Steven N Lichtman; J Wang; B Hummel; S Lacey; Ryan Sartor
A rat model of ileal pouch-rectal anastomosis.
Inflammatory bowel diseases 1998;4(3):187-95.
1998: Claus Hellerbrand; Christian Jobin; LL Licato; Ryan Sartor; David A Brenner
Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells.
The American journal of physiology 1998;275(2 Pt 1):G269-78.
1998: Christian Jobin; Claus Hellerbrand; LL Licato; David A Brenner; Ryan Sartor
Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors.
Gut 1998;42(6):779-87.
1998: Claus Hellerbrand; Christian Jobin; Yuji Iimuro; LL Licato; Ryan Sartor; David A Brenner
Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor.
Hepatology (Baltimore, Md.) 1998;27(5):1285-95.
1998: Antoni Stadnicki; Ryan Sartor; R Janardham; A Majluf-Cruz; Charles Kettner; AA Adam; Robert W Colman
Specific inhibition of plasma kallikrein modulates chronic granulomatous intestinal and systemic inflammation in genetically susceptible rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(3):325-33.
1998: Ryan Sartor
Postoperative recurrence of Crohn's disease: the enemy is within the fecal stream.
Gastroenterology 1998;114(2):398-400.
1998: Robert W Colman; Ryan Sartor; AA Adam; Raul A DeLa Cadena; Antoni Stadnicki
The plasma kallikrein-kinin system in sepsis, inflammatory arthritis, and enterocolitis.
Clinical reviews in allergy & immunology 1998;16(4):365-84.
1998: Christian Jobin; Asit Panja; Claus Hellerbrand; Yuji Iimuro; J Didonato; David A Brenner; Ryan Sartor
Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):410-8.
1997: Ryan Sartor
Review article: How relevant to human inflammatory bowel disease are current animal models of intestinal inflammation?
Alimentary pharmacology & therapeutics 1997;11 Suppl 3():89-96; discussion 96-7.
1997: Ryan Sartor
Review article: Role of the enteric microflora in the pathogenesis of intestinal inflammation and arthritis.
Alimentary pharmacology & therapeutics 1997;11 Suppl 3():17-22; discussion 22-3.
1997: Ryan Sartor
Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases.
The American journal of gastroenterology 1997;92(12 Suppl):5S-11S.
1997: Ryan Sartor
The influence of normal microbial flora on the development of chronic mucosal inflammation.
Research in immunology 1997;148(8-9):567-76.
1997: Robert W Colman; Antoni Stadnicki; Charles Kettner; AA Adam; Raul A DeLa Cadena; Ryan Sartor
Activation of the kallikrein-kinin system in arthritis and enterocolitis in genetically susceptible rats: modulation by a selective plasma kallikrein inhibitor.
Proceedings of the Association of American Physicians 1997;109(1):10-22.
1997: Christian Jobin; Stephen J Haskill; L Mayer; Asit Panja; Ryan Sartor
Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):226-34.
1996: Hans Herfarth; S P Mohanty; Heiko C Rath; S Tonkonogy; Ryan Sartor
Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers.
Gut 1996;39(6):836-45.
1996: E A van Tol; Peter Petrusz; P Kay Lund; Mitsuo Yamauchi; Ryan Sartor
Local production of corticotropin releasing hormone is increased in experimental intestinal inflammation in rats.
Gut 1996;39(3):385-92.
1996: Heiko C Rath; Hans Herfarth; J S Ikeda; W B Grenther; T E Hamm; Edward Balish; J D Taurog; R E Hammer; Kenneth H Wilson; Ryan Sartor
Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.
The Journal of clinical investigation 1996;98(4):945-53.
1996: Antoni Stadnicki; Raul A DeLa Cadena; Ryan Sartor; Charles Kettner; Robert W Colman
The contact system in experimental enterocolitis.
Immunopharmacology 1996;33(1-3):314-6.
1996: Antoni Stadnicki; Raul A DeLa Cadena; Ryan Sartor; D Bender; Charles Kettner; Heiko C Rath; AA Adam; Robert W Colman
Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in Lewis rat.
Digestive diseases and sciences 1996;41(5):912-20.
1996: Ryan Sartor; Raul A DeLa Cadena; K D Green; Antoni Stadnicki; S W Davis; J H Schwab; A A Adam; P Raymond; R W Colman
Selective kallikrein-kinin system activation in inbred rats differentially susceptible to granulomatous enterocolitis.
Gastroenterology 1996;110(5):1467-81.
1996: Ryan Sartor; Heiko C Rath; Steven N Lichtman; E A van Tol
Animal models of intestinal and joint inflammation.
Baillière's clinical rheumatology 1996;10(1):55-76.
1996: Ryan Sartor
Cytokine regulation of experimental intestinal inflammation in genetically engineered and T-lymphocyte reconstituted rodents.
Alimentary pharmacology & therapeutics 1996;10 Suppl 2():36-42; discussion 43-4.
1995: Charles O Elson; Ryan Sartor; G S Tennyson; R H Riddell
Experimental models of inflammatory bowel disease.
Gastroenterology 1995;109(4):1344-67.
1995: Ryan Sartor
Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease.
Gastroenterology clinics of North America 1995;24(3):475-507.
1995: Steven N Lichtman; J Wang; Ryan Sartor; C Zhang; D Bender; F G Dalldorf; J H Schwab
Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: role of cytokines, bacteria, and bacterial polymers.
Infection and immunity 1995;63(6):2295-301.
1995: Raul A DeLa Cadena; Antoni Stadnicki; A B Uknis; Ryan Sartor; Charles Kettner; AA Adam; Robert W Colman
Inhibition of plasma kallikrein prevents peptidoglycan-induced arthritis in the Lewis rat.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(5):446-52.
1994: Ryan Sartor
Cyclosporine therapy for inflammatory bowel disease.
The New England journal of medicine 1994;330(26):1897-8.
1994: R D McCall; S Haskill; Ellen M Zimmermann; P Kay Lund; R C Thompson; Ryan Sartor
Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats.
Gastroenterology 1994;106(4):960-72.
1994: Ryan Sartor
Cytokines in intestinal inflammation: pathophysiological and clinical considerations.
Gastroenterology 1994;106(2):533-9.
1993: T Yamada; E Deitch; R D Specian; M A Perry; Ryan Sartor; Matthew B Grisham
Mechanisms of acute and chronic intestinal inflammation induced by indomethacin.
Inflammation 1993;17(6):641-62.
1993: Steven N Lichtman; S Bachmann; Sergio Munoz; J H Schwab; D E Bender; Ryan Sartor; John J Lemasters
Bacterial cell wall polymers (peptidoglycan-polysaccharide) cause reactivation of arthritis.
Infection and immunity 1993;61(11):4645-53.
1993: Ellen M Zimmermann; Ryan Sartor; R D McCall; M Pardo; D Bender; P Kay Lund
Insulinlike growth factor I and interleukin 1 beta messenger RNA in a rat model of granulomatous enterocolitis and hepatitis.
Gastroenterology 1993;105(2):399-409.
1993: Steven N Lichtman; Ryan Sartor
Examining the role of inflammatory cytokines in chronic inflammatory bowel disease.
Journal of pediatric gastroenterology and nutrition 1993;16(3):239-40.
1993: T Yamada; Ryan Sartor; S Marshall; R D Specian; Matthew B Grisham
Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats.
Gastroenterology 1993;104(3):759-71.
1992: Kim L Isaacs; Ryan Sartor; S Haskill
Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification.
Gastroenterology 1992;103(5):1587-95.
1992: C J Woolverton; L C Holt; D Mitchell; Ryan Sartor
Identification and characterization of rat intestinal lamina propria cells: consequences of microbial colonization.
Veterinary immunology and immunopathology 1992;34(1-2):127-38.
1992: Steven N Lichtman; E E Okoruwa; J Keku; J H Schwab; Ryan Sartor
Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth.
The Journal of clinical investigation 1992;90(4):1313-22.
1992: Raul A DeLa Cadena; Ryan Sartor; AA Adam; B Raymond; F Legris; Robert W Colman
Role of kallikrein-kinin system in the pathogenesis of bacterial cell wall-induced inflammation and enterocolitis.
Transactions of the Association of American Physicians 1992;105():229-37.
1991: Steven N Lichtman; Ryan Sartor
Duct proliferation following biliary obstruction in the rat.
Gastroenterology 1991;100(6):1785-7.
1991: Steven N Lichtman; J Keku; Richard Clark; J H Schwab; Ryan Sartor
Biliary tract disease in rats with experimental small bowel bacterial overgrowth.
Hepatology (Baltimore, Md.) 1991;13(4):766-72.
1991: Raul A DeLa Cadena; K J Laskin; R A Pixley; Ryan Sartor; J H Schwab; N Back; G S Bedi; Robert S Fisher; Robert W Colman
Role of kallikrein-kinin system in pathogenesis of bacterial cell wall-induced inflammation.
The American journal of physiology 1991;260(2 Pt 1):G213-9.
1991: Steven N Lichtman; J Keku; J H Schwab; Ryan Sartor
Evidence for peptidoglycan absorption in rats with experimental small bowel bacterial overgrowth.
Infection and immunity 1991;59(2):555-62.
1991: Steven N Lichtman; J Keku; J H Schwab; Ryan Sartor
Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline.
Gastroenterology 1991;100(2):513-9.
1991: Steven N Lichtman; Ryan Sartor
Hepatobiliary injury associated with experimental small-bowel bacterial overgrowth in rats.
Immunologic research 1991;10(3-4):528-31.
1991: Ryan Sartor
Pathogenetic and clinical relevance of cytokines in inflammatory bowel disease.
Immunologic research 1991;10(3-4):465-71.
1990: Steven N Lichtman; Ryan Sartor; J Keku; J H Schwab
Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth.
Gastroenterology 1990;98(2):414-23.
1989: Ryan Sartor
Importance of intestinal mucosal immunity and luminal bacterial cell wall polymers in the aetiology of inflammatory joint diseases.
Baillière's clinical rheumatology 1989;3(2):223-45.
1989: Ryan Sartor; S K Anderle; N Rifai; D A Goo; W J Cromartie; J H Schwab
Protracted anemia associated with chronic, relapsing systemic inflammation induced by arthropathic peptidoglycan-polysaccharide polymers in rats.
Infection and immunity 1989;57(4):1177-85.
1989: C J Woolverton; J J White; Ryan Sartor
Eicosanoid regulation of acute intestinal vascular permeability induced by intravenous peptidoglycan-polysaccharide polymers.
Agents and actions 1989;26(3-4):301-9.
1988: Ryan Sartor; T M Bond; J H Schwab
Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury.
Infection and immunity 1988;56(8):2101-8.
1987: D Provenzale; Robert S Sandler; D R Wood; S L Levinson; J T Frakes; Ryan Sartor; A L Jackson; H B Kinard; E H Wagner; D W Powell
Development of a scoring system to predict mortality from upper gastrointestinal bleeding.
The American journal of the medical sciences 1987;294(1):26-32.
1987: S A Stimpson; R E Esser; P B Carter; Ryan Sartor; W J Cromartie; J H Schwab
Lipopolysaccharide induces recurrence of arthritis in rat joints previously injured by peptidoglycan-polysaccharide.
The Journal of experimental medicine 1987;165(6):1688-702.
1987: Ryan Sartor; T M Bond; K Y Compton; D R Cleland
Intestinal absorption of bacterial cell wall polymers in rats.
Advances in experimental medicine and biology 1987;216A():835-9.
1986: Ryan Sartor; S K Anderle; W J Cromartie; J H Schwab
Localized gut-associated lymphoid tissue hemorrhage induced by intravenous peptidoglycan-polysaccharide polymers.
Infection and immunity 1986;51(2):521-8.
1985: Ryan Sartor; W J Cromartie; D W Powell; J H Schwab
Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments.
Gastroenterology 1985;89(3):587-95.
1981: Robert S Sandler; Ryan Sartor; Eugene M Bozymski
Endoscopic appearance of cancer metastatic to the stomach.
Journal of clinical gastroenterology 1981;3 Suppl 1():35-7.