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Bart Williams

Research Profile

Living Beings

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Genes, Retinoblastoma

Anatomy

Cell Line

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Travis A Burgers; Caitlyn J Collins; Martin F Hoffmann; Clifford B Jones; James J Mason; Michael R Morris; Heidi L Ploeg; Debra L Sietsema; Martin A Alvarado; Juraj Zahatnansky; Bart Williams
Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing.
Ryan Riddle; Kyle K Van Koevering; Thomas L Clemens; Cassandra R Diegel; Marie-Claude Faugere; Julie M Leslie; Bart Williams
Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition.
James A Stefater; Bart Williams; MARSHA WILLS-KARP; Terry Yamaguchi; Rieko Ajima; Adam R Burr; April C Carpenter; Jieqing Fan; Napoleone Ferrara; Holger Gerhardt; Ian Lewkowich; Giovanni Mariggi; Jeffery D Molkentin; Jeffrey W Pollard; Sujata Rao; Richard Lang
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

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All Publications

2013: Travis A Burgers; Caitlyn J Collins; Martin F Hoffmann; Clifford B Jones; James J Mason; Michael R Morris; Heidi L Ploeg; Debra L Sietsema; Martin A Alvarado; Juraj Zahatnansky; Bart Williams
Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing.
PloS one 2013;8(5):e63857.
2013: Ryan Riddle; Kyle K Van Koevering; Thomas L Clemens; Cassandra R Diegel; Marie-Claude Faugere; Julie M Leslie; Bart Williams
Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition.
PloS one 2013;8(5):e63323.
2011: James A Stefater; Bart Williams; MARSHA WILLS-KARP; Terry Yamaguchi; Rieko Ajima; Adam R Burr; April C Carpenter; Jieqing Fan; Napoleone Ferrara; Holger Gerhardt; Ian Lewkowich; Giovanni Mariggi; Jeffery D Molkentin; Jeffrey W Pollard; Sujata Rao; Richard Lang
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.
Nature 2011;474(7352):511-5.
2011: Yajun Cui; Han Gerrits; Jan A Gossen; Xi He; Christina M Jacobsen; Qingyun Liu; Bryan T MacDonald; Susann Matthes; Faika Mseeh; Paul J Niziolek; David R Powell; Daniel R Robinson; Natalia Alenina; Michael Bader; Robert Brommage; Ronald A Conlon; Matthew L Warman; Bart Williams; Qi M Yang; Brian Zambrowicz; Zhendong Zhong; Cassandra R Zylstra; Alexander G Robling
Lrp5 functions in bone to regulate bone mass.
Nature medicine 2011;17(6):684-91.
2011: Mei Wan; Jun Li; Katie Herbst; Jin Zhang; Bing Yu; Xiangwei Wu; Tao Qiu; Weiqi Lei; Charlotta Lindvall; Bart Williams; Hairong Ma; Fengjie Zhang; Xu Cao
LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Gα(s).
Science signaling 2011;4(164):ra15.
2010: Cassandra R Diegel; Kathleen R Cho; Adel K El-Naggar; Bart Williams; Charlotta Lindvall
Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.
Cancer research 2010;70(22):9143-52.
2010: Marlon O Coulibaly; Debra L Sietsema; Travis A Burgers; Jim Mason; Bart Williams; Clifford B Jones
Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing.
Critical reviews in eukaryotic gene expression 2010;20(2):105-27.
2010: James J Mason; Bart Williams
SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease.
Journal of osteoporosis 2010;2010():.
2009: Chao-Nan Qian; Kyle A Furge; Jared Knol; Dan Huang; Jindong Chen; Karl J Dykema; Eric J Kort; Aaron Massie; Sok Kean Khoo; Kristin Vanden Beldt; James Resau; John Anema; Richard J Kahnoski; Hans Morreau; Philippe Camparo; Eva Comperat; Mathilde Sibony; Yves Denoux; Vincent Molinie; Annick Vieillefond; Charis Eng; Bart Williams; Bin Tean Teh
Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models.
Cancer research 2009;69(21):8256-64.
2009: Rogerio M Castilho; Cristiane Helena Squarize; Lewis A Chodosh; Bart Williams; J Silvio Gutkind
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.
Cell stem cell 2009;5(3):279-89.
2009: Bart Williams; Karl L Insogna
Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(2):171-8.
2009: Nisha M Badders; Shruti Goel; Rod J Clark; Kristine S Klos; Soyoung Kim; Anna Bafico; Charlotta Lindvall; Bart Williams; Caroline M Alexander
The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.
PloS one 2009;4(8):e6594.
2009: Charlotta Lindvall; Cassandra R Zylstra; Nicole Evans; Richard A West; Karl Dykema; Kyle A Furge; Bart Williams
The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.
PloS one 2009;4(6):e5813.
2008: Cassandra R Zylstra; Chao Wan; K K VanKoevering; A K Sanders; Charlotta Lindvall; Thomas Landes Clemens; Bart Williams
Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.
Journal of musculoskeletal & neuronal interactions 2008;8(4):291-3.
2008: Zhijian Qian; Lina Chen; Anthony A Fernald; Bart Williams; Michelle M Le Beau
A critical role for Apc in hematopoietic stem and progenitor cell survival.
The Journal of experimental medicine 2008;205(9):2163-75.
2008: Daniel R Robinson; Cassandra R Zylstra; Bart Williams
Wnt signaling and prostate cancer.
Current drug targets 2008;9(7):571-80.
2008: Pengfei Wang; Michael R Bowl; Stephanie Bender; Jun Peng; Leslie Farber; Jindong Chen; Asif Ali; Zhongfa Zhang; ARTHUR S ALBERTS; Rajesh V Thakker; Ali Shilatifard; Bart Williams; Bin Tean Teh
Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice.
Molecular and cellular biology 2008;28(9):2930-40.
2008: Malathy Puthan Veedu Shekhar; Brigitte Gerard; Robert Pauley; Bart Williams; Larry Tait
Rad6B is a positive regulator of beta-catenin stabilization.
Cancer research 2008;68(6):1741-50.
2008: Joshua Wolf; Todd R Palmby; Julie Gavard; Bart Williams; J Silvio Gutkind
Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6.
FEBS letters 2008;582(2):255-61.
2008: Jindong Chen; Kunihiko Futami; David Petillo; Jun Peng; Pengfei Wang; Jared Knol; Yan Li; Sok Kean Khoo; Dan Huang; Chao-Nan Qian; Ping Zhao; Karl Dykema; Karl Dykyma; Racheal Zhang; Brian Cao; Ximing J Yang; Kyle A Furge; Bart Williams; Bin Tean Teh
Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia.
PloS one 2008;3(10):e3581.
2007: Takao Hinoi; Aytekin Akyol; Brian K Theisen; David O Ferguson; Joel K Greenson; Bart Williams; Kathleen R Cho; Eric R Fearon
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.
Cancer research 2007;67(20):9721-30.
2007: Charlotta Lindvall; Wen Bu; Bart Williams; Yi Li
Wnt signaling, stem cells, and the cellular origin of breast cancer.
Stem cell reviews 2007;3(2):157-68.
2007: Rong Wu; Neali Hendrix-Lucas; Rork Kuick; Yali Zhai; Donald R Schwartz; Aytekin Akyol; Samir Hanash; David E Misek; Hidetaka Katabuchi; Bart Williams; Eric R Fearon; Kathleen R Cho
Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.
Cancer cell 2007;11(4):321-33.
2007: Katia J Bruxvoort; Holli M Charbonneau; Troy A. Giambernardi; James C Goolsby; Chao-Nan Qian; Cassandra R Zylstra; Daniel R Robinson; Pradip Roy-Burman; Aubie K Shaw; Bree D Buckner-Berghuis; Robert E Sigler; James Resau; Ruth Sullivan; Wade Bushman; Bart Williams
Inactivation of Apc in the mouse prostate causes prostate carcinoma.
Cancer research 2007;67(6):2490-6.
2007: John J Young; Jennifer L Bromberg-White; Cassandra R Zylstra; Joseph T Church; Elissa Boguslawski; James Resau; Bart Williams; Nicholas S Duesbery
LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.
PLoS pathogens 2007;3(3):e27.
2007: Ximeng Liu; Katia J Bruxvoort; Cassandra R Zylstra; Jiarong Liu; Rachel Cichowski; Marie-Claude Faugere; Mary L Bouxsein; Chao Wan; Bart Williams; Thomas Landes Clemens
Lifelong accumulation of bone in mice lacking Pten in osteoblasts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2259-64.
2006: Charlotta Lindvall; Nicole C Evans; Cassandra R Zylstra; Yi Li; Caroline M Alexander; Bart Williams
The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis.
The Journal of biological chemistry 2006;281(46):35081-7.
2006: Chun Zhang; Dong Kong; Min-Han Tan; Donald L Pappas; Peng-Fei Wang; Jindong Chen; Leslie Farber; Nian Zhang; Han-Mo Koo; Michael Weinreich; Bart Williams; Bin Tean Teh
Parafibromin inhibits cancer cell growth and causes G1 phase arrest.
Biochemical and biophysical research communications 2006;350(1):17-24.
2006: Ken Inoki; Hongjiao Ouyang; Tianqing Zhu; Charlotta Lindvall; Yian Wang; Xiaojie Zhang; Qian Yang; Christina Bennett; Yuko Harada; Kryn Stankunas; Cun-Yu Wang; Xi He; Ormond A MacDougald; Ming You; Bart Williams; Kun-Liang Guan
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.
Cell 2006;126(5):955-68.
2006: Ki-Sook Park; Soung Hoo Jeon; Sung-Eun Kim; Young Yil Bahk; Sheri L Holmen; Bart Williams; Kwang-Chul Chung; Young-Joon Surh; Kang-Yell Choi
APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
Journal of cell science 2006;119(Pt 5):819-27.
2005: Maria Domenica Castellone; Hidemi Teramoto; Bart Williams; Kirk M Druey; J Silvio Gutkind
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.
Science (New York, N.Y.) 2005;310(5753):1504-10.
2005: Sheri L Holmen; Bart Williams
Essential role for Ras signaling in glioblastoma maintenance.
Cancer research 2005;65(18):8250-5.
2005: Sheri L Holmen; Cassandra R Zylstra; Aditi Mukherjee; Robert E Sigler; Marie-Claude Faugere; Mary L Bouxsein; Lianfu Deng; Thomas Landes Clemens; Bart Williams
Essential role of beta-catenin in postnatal bone acquisition.
The Journal of biological chemistry 2005;280(22):21162-8.
2005: Minrong Ai; Sheri L Holmen; Wim Van Hul; Bart Williams; Matthew L Warman
Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling.
Molecular and cellular biology 2005;25(12):4946-55.
2005: Sheri L Holmen; Scott A Robertson; Cassandra R Zylstra; Bart Williams
Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.
Biochemical and biophysical research communications 2005;328(2):533-9.
2005: Scott A Robertson; Jacqueline Schoumans; Brendan David Looyenga; Jason A Yuhas; Cassandra R Zylstra; Julie M Koeman; Pamela J Swiatek; Bin Tean Teh; Bart Williams
Spectral karyotyping of sarcomas and fibroblasts derived from Ink4a/Arf-deficient mice reveals chromosomal instability in vitro.
International journal of oncology 2005;26(3):629-34.
2005: Chao-Nan Qian; Jared Knol; Peter Igarashi; Fangming Lin; Uko Zylstra; Bin Tean Teh; Bart Williams
Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.
The Journal of biological chemistry 2005;280(5):3938-45.
2004: Sheri L Holmen; Troy A. Giambernardi; Cassandra R Zylstra; Bree D Buckner-Berghuis; James Resau; J Fred Hess; Vaida Glatt; Mary L Bouxsein; Minrong Ai; Matthew L Warman; Bart Williams
Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(12):2033-40.
2004: Benjamin T Spike; Alexandra Dirlam; Benjamin C Dibling; James Marvin; Bart Williams; Tyler Jacks; Kay F Macleod
The Rb tumor suppressor is required for stress erythropoiesis.
The EMBO journal 2004;23(21):4319-29.
2004: Jennifer L Bromberg-White; Craig Webb; Veronique S Patacsil; Cindy Miranti; Bart Williams; Sheri L Holmen
Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector.
Journal of virology 2004;78(9):4914-6.
2002: Masayuki Takahashi; Ximing J Yang; Todd T Lavery; Kyle A Furge; Bart Williams; Maria Tretiakova; Anthony G Montag; Nicholas J Vogelzang; Gian G Re; A Julian Garvin; Stefan Söderhäll; Susumu Kagawa; Debra Hazel-Martin; Agneta Nordenskjold; Bin Tean Teh
Gene expression profiling of favorable histology Wilms tumors and its correlation with clinical features.
Cancer research 2002;62(22):6598-605.
2002: Sheri L Holmen; Adrian Salic; Cassandra R Zylstra; Marc W Kirschner; Bart Williams
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.
The Journal of biological chemistry 2002;277(38):34727-35.
2002: Hong Yang; Bart Williams; Phillip W Hinds; T Shane Shih; Tyler Jacks; Roderick T Bronson; David M Livingston
Tumor suppression by a severely truncated species of retinoblastoma protein.
Molecular and cellular biology 2002;22(9):3103-10.
2001: Marta Lipinski; Kay F Macleod; Bart Williams; T L Mullaney; Denise Crowley; Tyler Jacks
Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system.
The EMBO journal 2001;20(13):3402-13.
2000: Julien Sage; GJ Mulligan; Laura D Attardi; A Miller; Shuyan Chen; Bart Williams; E Theodorou; Tyler Jacks
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.
Genes & development 2000;14(23):3037-50.
2000: Bart O Williams; Bart Williams; Michael Klymkowsky; Harold Varmus
A comparative evaluation of beta-catenin and plakoglobin signaling activity.
Oncogene 2000;19(50):5720-8.
2000: Karen Joyce Dunn; Bart Williams; Y Li; William J Pavan
Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10050-5.
1999: A M Zorn; Bart Williams; Bart O Williams; P Lavender; Michael Klymkowsky; Harold Varmus
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin.
Molecular cell 1999;4(4):487-98.
1999: Michael Klymkowsky; Bart O Williams; Bart Williams; Harold Varmus; Y E Vourgourakis
Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling.
Molecular biology of the cell 1999;10(10):3151-69.
1999: Galen H Fisher; Sandra Orsulic; Eric C Holland; WP Hively; Yi Li; Brian C Lewis; Bart Williams; Harold Varmus
Development of a flexible and specific gene delivery system for production of murine tumor models.
Oncogene 1999;18(38):5253-60.
1998: Lili Yamasaki; R Bronson; Bart Williams; Nicholas J Dyson; Ed Harlow; Tyler Jacks
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.
Nature genetics 1998;18(4):360-4.
1996: M H Lee; Bart Williams; G Mulligan; S Mukai; Roderick T Bronson; Nicholas J Dyson; Ed Harlow; Tyler Jacks
Targeted disruption of p107: functional overlap between p107 and Rb.
Genes & development 1996;10(13):1621-32.
1996: Rafael E Herrera; V P Sah; Bart Williams; Tomi Mäkelä; Robert A. Weinberg; Tyler Jacks
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts.
Molecular and cellular biology 1996;16(5):2402-7.
1996: Bart Williams; Tyler Jacks
Mechanisms of carcinogenesis and the mutant mouse.
Current opinion in genetics & development 1996;6(1):65-70.
1995: V P Sah; Laura D Attardi; G J Mulligan; Bart Williams; Roderick T Bronson; Tyler Jacks
A subset of p53-deficient embryos exhibit exencephaly.
Nature genetics 1995;10(2):175-80.
1995: Arthur L. Haas; O Baboshina; Bart Williams; L M Schwartz
Coordinated induction of the ubiquitin conjugation pathway accompanies the developmentally programmed death of insect skeletal muscle.
The Journal of biological chemistry 1995;270(16):9407-12.
1994: Bart Williams; E M Schmitt; L Remington; Roderick T Bronson; D M Albert; Robert A. Weinberg; Tyler Jacks
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.
The EMBO journal 1994;13(18):4251-9.
1994: S D Morgenbesser; Bart Williams; Tyler Jacks; Ronald A DePinho
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
Nature 1994;371(6492):72-4.
1994: Bart Williams; L Remington; D M Albert; S Mukai; Roderick T Bronson; Tyler Jacks
Cooperative tumorigenic effects of germline mutations in Rb and p53.
Nature genetics 1994;7(4):480-4.
1994: R J Slebos; M H Lee; B S Plunkett; T D Kessis; Bart Williams; Tyler Jacks; L Hedrick; Michael B Kastan; Kathleen R Cho
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5320-4.
1994: Tyler Jacks; L Remington; Bart Williams; E M Schmitt; Shlomit Halachmi; Roderick T Bronson; Robert A. Weinberg
Tumor spectrum analysis in p53-mutant mice.
Current biology : CB 1994;4(1):1-7.
1994: Bart Williams; S D Morgenbesser; Ronald A DePinho; Tyler Jacks
Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53.
Cold Spring Harbor symposia on quantitative biology 1994;59():449-57.
1993: J Chen; J R Gorman; V Stewart; Bart Williams; T Jacks; F W Alt
Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells.
Current biology : CB 1993;3(7):405-13.