John Carpenter

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Fradkin Amber Haynes; Carpenter John F; Randolph Theodore W
Immunogenicity of aggregates of recombinant human growth hormone in mouse models.
Bee Jared S; Chiu David; Sawicki Suzanne; Stevenson Jennifer L; Chatterjee Koustuv; Freund Erwin; Carpenter John F; Randolph Theodore W
Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies.
Roy Shouvik; Mason Bruce D; Schöneich Christian S; Carpenter John F; Boone Thomas C; Kerwin Bruce A
Light-induced aggregation of type I soluble tumor necrosis factor receptor.

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All Publications

2009: Fradkin Amber Haynes; Carpenter John F; Randolph Theodore W
Immunogenicity of aggregates of recombinant human growth hormone in mouse models.
Journal of pharmaceutical sciences 2009;98(9):3247-64.
2009: Bee Jared S; Chiu David; Sawicki Suzanne; Stevenson Jennifer L; Chatterjee Koustuv; Freund Erwin; Carpenter John F; Randolph Theodore W
Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies.
Journal of pharmaceutical sciences 2009;98(9):3218-38.
2009: Roy Shouvik; Mason Bruce D; Schöneich Christian S; Carpenter John F; Boone Thomas C; Kerwin Bruce A
Light-induced aggregation of type I soluble tumor necrosis factor receptor.
Journal of pharmaceutical sciences 2009;98(9):3182-99.
2009: Bee Jared S; Nelson Stephanie A; Freund Erwin; Carpenter John F; Randolph Theodore W
Precipitation of a monoclonal antibody by soluble tungsten.
Journal of pharmaceutical sciences 2009;98(9):3290-301.
2009: Estey Tia; Vessely Christina; Randolph Theodore W; Henderson Ian; Braun Latoya Jones; Nayar Rajiv; Carpenter John F
Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry.
Journal of pharmaceutical sciences 2009;98(9):2994-3012.
2009: Vessely Christina; Estey Tia; Randolph Theodore W; Henderson Ian; Cooper Julianne; Nayar Rajiv; Braun Latoya Jones; Carpenter John F
Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution.
Journal of pharmaceutical sciences 2009;98(9):2970-93.
2009: Katayama Derrick S; Carpenter John F; Menard Kevin P; Manning Mark Cornell; Randolph Theodore W
Mixing properties of lyophilized protein systems: a spectroscopic and calorimetric study.
Journal of pharmaceutical sciences 2009;98(9):2954-69.
2009: Lin Jen-Jen; Meyer Jeffrey D; Carpenter John F; Manning Mark Cornell
Aggregation of human serum albumin during a thermal viral inactivation step.
International journal of biological macromolecules 2009;45(2):91-6.
2009: Bee Jared S; Stevenson Jennifer L; Mehta Bhavya; Svitel Juraj; Pollastrini Joey; Platz Robert; Freund Erwin; Carpenter John F; Randolph Theodore W
Response of a concentrated monoclonal antibody formulation to high shear.
Biotechnology and bioengineering 2009;103(5):936-43.
2009: Carpenter John F; Randolph Theodore W; Jiskoot Wim; Crommelin Daan J A; Middaugh C Russell; Winter Gerhard; Fan Ying-Xin; Kirshner Susan; Verthelyi Daniela; Kozlowski Steven; Clouse Kathleen A; Swann Patrick G; Rosenberg Amy; Cherney Barry
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.
Journal of pharmaceutical sciences 2009;98(4):1201-5.
2009: Clausi Amber L; Morin Andrea; Carpenter John F; Randolph Theodore W
Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine.
Journal of pharmaceutical sciences 2009;98(1):114-21.
2009: Tyagi Anil K; Randolph Theodore W; Dong Aichun; Maloney Kevin M; Hitscherich Carl; Carpenter John F
IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles.
Journal of pharmaceutical sciences 2009;98(1):94-104.
2008: Roy Shouvik; Henderson Ian; Nayar Rajiv; Randolph Theodore W; Carpenter John F
Effect of pH on stability of recombinant botulinum serotype A vaccine in aqueous solution and during storage of freeze-dried formulations.
Journal of pharmaceutical sciences 2008;97(12):5132-46.
2008: Clausi Amber; Cummiskey Jessica; Merkley Scott; Carpenter John F; Braun Latoya Jones; Randolph Theodore W
Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine.
Journal of pharmaceutical sciences 2008;97(12):5252-62.
2008: Cape Stephen P; Villa Joseph A; Huang Edward T S; Yang Tzung-Horng; Carpenter John F; Sievers Robert E
Preparation of active proteins, vaccines and pharmaceuticals as fine powders using supercritical or near-critical fluids.
Pharmaceutical research 2008;25(9):1967-90.
2008: Alford John R; Kwok Stanley C; Roberts Jennifer N; Wuttke Deborah S; Kendrick Brent S; Carpenter John F; Randolph Theodore W
High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization.
Journal of pharmaceutical sciences 2008;97(8):3035-50.
2008: Alford John R; Kendrick Brent S; Carpenter John F; Randolph Theodore W
High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics.
Journal of pharmaceutical sciences 2008;97(8):3005-21.
2008: Alford John R; Kendrick Brent S; Carpenter John F; Randolph Theodore W
Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium.
Analytical biochemistry 2008;377(2):128-33.
2008: Clausi Amber L; Merkley Scott A; Carpenter John F; Randolph Theodore W
Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying.
Journal of pharmaceutical sciences 2008;97(6):2049-61.
2008: Kueltzo Lisa A; Wang Wei; Randolph Theodore W; Carpenter John F
Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing.
Journal of pharmaceutical sciences 2008;97(5):1801-12.
2008: Katayama Derrick S; Carpenter John F; Manning Mark Cornell; Randolph Theodore W; Setlow Peter; Menard Kevin P
Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry.
Journal of pharmaceutical sciences 2008;97(2):1013-24.
2007: Vessely Christina; Estey Tia; Randolph Theodore W; Henderson Ian; Nayar Rajiv; Carpenter John F
Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants.
Journal of pharmaceutical sciences 2007;96(9):2375-89.
2007: Thirumangalathu Renuka; Krishnan Sampathkumar; Bondarenko Pavel; Speed-Ricci Margaret; Randolph Theodore W; Carpenter John F; Brems David N
Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics.
Biochemistry 2007;46(21):6213-24.
2007: Estey Tia; Cantore Miriam; Weston Philip A; Carpenter John F; Petrash J Mark; Vasiliou Vasilis
Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1.
The Journal of biological chemistry 2007;282(7):4382-92.
2007: Gabrielson John P; Brader Mark L; Pekar Allen H; Mathis Kathrin B; Winter Gerhard; Carpenter John F; Randolph Theodore W
Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity.
Journal of pharmaceutical sciences 2007;96(2):268-79.
2006: Thirumangalathu Renuka; Krishnan Sampathkumar; Brems David N; Randolph Theodore W; Carpenter John F
Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor.
Journal of pharmaceutical sciences 2006;95(7):1480-97.
2006: Estey Tia; Kang Jichao; Schwendeman Steven P; Carpenter John F
BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systems.
Journal of pharmaceutical sciences 2006;95(7):1626-39.
2006: Dong Aichun; Jones LaToya S; Kerwin Bruce A; Krishnan Sampath; Carpenter John F
Secondary structures of proteins adsorbed onto aluminum hydroxide: infrared spectroscopic analysis of proteins from low solution concentrations.
Analytical biochemistry 2006;351(2):282-9.
2006: Roy Shouvik; Katayama Derrick; Dong Aichun; Kerwin Bruce A; Randolph Theodore W; Carpenter John F
Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist.
Biochemistry 2006;45(12):3898-911.
2006: Lee Seung-Hyun; Carpenter John F; Chang Byeong S; Randolph Theodore W; Kim Yong-Sung
Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure.
Protein science : a publication of the Protein Society 2006;15(2):304-13.
2006: Kim Yong-Sung; Randolph Theodore W; Seefeldt Matthew B; Carpenter John F
High-pressure studies on protein aggregates and amyloid fibrils.
Methods in enzymology 2006;413():237-53.
2005: Chi Eva Y; Kendrick Brent S; Carpenter John F; Randolph Theodore W
Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist.
Journal of pharmaceutical sciences 2005;94(12):2735-48.
2005: Vessely Christina R; Carpenter John F; Schwartz Daniel K
Calcium-induced changes to the molecular conformation and aggregate structure of beta-casein at the air-water interface.
Biomacromolecules 2005;6(6):3334-44.
2005: Seefeldt Matthew B; Kim Yong-Sung; Tolley Kevin P; Seely Jim; Carpenter John F; Randolph Theodore W
High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies.
Protein science : a publication of the Protein Society 2005;14(9):2258-66.
2005: Bai Shujun; Nayar Rajiv; Carpenter John F; Manning Mark Cornell
Noninvasive determination of protein conformation in the solid state using near infrared (NIR) spectroscopy.
Journal of pharmaceutical sciences 2005;94(9):2030-8.
2005: Chou Danny K; Krishnamurthy Rajesh; Randolph Theodore W; Carpenter John F; Manning Mark Cornell
Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation.
Journal of pharmaceutical sciences 2005;94(6):1368-81.
2005: Roy Shouvik; Jung Rose; Kerwin Bruce A; Randolph Theodore W; Carpenter John F
Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations.
Journal of pharmaceutical sciences 2005;94(2):382-96.
2005: Chi Eva Y; Weickmann Joachim; Carpenter John F; Manning Mark C; Randolph Theodore W
Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation.
Journal of pharmaceutical sciences 2005;94(2):256-74.
2004: Zhang Ye; Roy Shouvik; Jones Latoya S; Krishnan Sampathkumar; Kerwin Bruce A; Chang Byeong S; Manning Mark C; Randolph Theodore W; Carpenter John F
Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution.
Journal of pharmaceutical sciences 2004;93(12):3076-89.
2004: Seefeldt Matthew B; Ouyang Jun; Froland Wayne A; Carpenter John F; Randolph Theodore W
High-pressure refolding of bikunin: efficacy and thermodynamics.
Protein science : a publication of the Protein Society 2004;13(10):2639-50.
2004: Bai Shu Jun; Rani Meena; Suryanarayanan Raj; Carpenter John F; Nayar Rajiv; Manning Mark C
Quantification of glycine crystallinity by near-infrared (NIR) spectroscopy.
Journal of pharmaceutical sciences 2004;93(10):2439-47.
2004: Buchanan Sandhya S; Gross Sherilyn A; Acker Jason P; Toner Mehmet; Carpenter John F; Pyatt David W
Cryopreservation of stem cells using trehalose: evaluation of the method using a human hematopoietic cell line.
Stem cells and development 2004;13(3):295-305.
2004: Meyer Jeffrey D; Jun Bai Shu; Rani Meena; Suryanarayanan Raj; Nayar Rajiv; Carpenter John F; Manning Mark C
Infrared spectroscopic studies of protein formulations containing glycine.
Journal of pharmaceutical sciences 2004;93(5):1359-66.
2004: Soenderkaer Susanne; Carpenter John F; van de Weert Marco; Hansen Lars Lindgaard; Flink James; Frokjaer Sven
Effects of sucrose on rFVIIa aggregation and methionine oxidation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;21(5):597-606.
2004: Garzon-Rodriguez William; Koval Rebecca L; Chongprasert Suchart; Krishnan Sampathkumar; Randolph Theodore W; Warne Nicholas W; Carpenter John F
Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures.
Journal of pharmaceutical sciences 2004;93(3):684-96.
2004: Meyer Jeffrey D; Manning Mark C; Carpenter John F
Effects of potassium bromide disk formation on the infrared spectra of dried model proteins.
Journal of pharmaceutical sciences 2004;93(2):496-506.
2003: Chi Eva Y; Krishnan Sampathkumar; Randolph Theodore W; Carpenter John F
Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation.
Pharmaceutical research 2003;20(9):1325-36.
2003: Kim Yong-Sung; Jones Latoya S; Dong Aichun; Kendrick Brent S; Chang Byeong S; Manning Mark C; Randolph Theodore W; Carpenter John F
Effects of sucrose on conformational equilibria and fluctuations within the native-state ensemble of proteins.
Protein science : a publication of the Protein Society 2003;12(6):1252-61.
2003: Chi Eva Y; Krishnan Sampathkumar; Kendrick Brent S; Chang Byeong S; Carpenter John F; Randolph Theodore W
Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.
Protein science : a publication of the Protein Society 2003;12(5):903-13.
2003: Webb Serena D; Cleland Jeffrey L; Carpenter John F; Randolph Theodore W
Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma.
Journal of pharmaceutical sciences 2003;92(4):715-29.
2003: Kim Yong-Sung; Randolph Theodore W; Manning Mark C; Stevens Fred J; Carpenter John F
Congo red populates partially unfolded states of an amyloidogenic protein to enhance aggregation and amyloid fibril formation.
The Journal of biological chemistry 2003;278(12):10842-50.
2003: Manzer Rizwan; Pappa Aglaia; Estey Tia; Sladek Norman; Carpenter John F; Vasiliou Vasilis
Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1.
Chemico-biological interactions 2003;143-144():45-53.
2003: Krishnan Sampathkumar; Chi Eva Y; Wood Stephen J; Kendrick Brent S; Li Cynthia; Garzon-Rodriguez William; Wypych Jette; Randolph Theodore W; Narhi Linda O; Biere Anja Leona; Citron Martin; Carpenter John F
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.
Biochemistry 2003;42(3):829-37.
2002: Garriques Liza Nielsen; Frokjaer Sven; Carpenter John F; Brange Jens
The effect of mutations on the structure of insulin fibrils studied by Fourier transform infrared (FTIR) spectroscopy and electron microscopy.
Journal of pharmaceutical sciences 2002;91(12):2473-80.
2002: Pikal-Cleland Katherine A; Cleland Jeffrey L; Anchordoquy Thomas J; Carpenter John F
Effect of glycine on pH changes and protein stability during freeze-thawing in phosphate buffer systems.
Journal of pharmaceutical sciences 2002;91(9):1969-79.
2002: Kim Yong-Sung; Randolph Theodore W; Stevens Fred J; Carpenter John F
Kinetics and energetics of assembly, nucleation, and growth of aggregates and fibrils for an amyloidogenic protein. Insights into transition states from pressure, temperature, and co-solute studies.
The Journal of biological chemistry 2002;277(30):27240-6.
2002: Webb Serena D; Golledge Stephen L; Cleland Jeffrey L; Carpenter John F; Randolph Theodore W
Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations.
Journal of pharmaceutical sciences 2002;91(6):1474-87.
2002: St John Richard J; Carpenter John F; Randolph Theodore W
High-pressure refolding of disulfide-cross-linked lysozyme aggregates: thermodynamics and optimization.
Biotechnology progress 2002;18(3):565-71.
2002: Krishnan Sampathkumar; Chi Eva Y; Webb Jonathan N; Chang Byeong S; Shan Daxian; Goldenberg Merrill; Manning Mark C; Randolph Theodore W; Carpenter John F
Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition.
Biochemistry 2002;41(20):6422-31.
2002: Randolph Theodore W; Seefeldt Matthew; Carpenter John F
High hydrostatic pressure as a tool to study protein aggregation and amyloidosis.
Biochimica et biophysica acta 2002;1595(1-2):224-34.
2002: Webb Serena D; Cleland Jeffrey L; Carpenter John F; Randolph Theodore W
A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20.
Journal of pharmaceutical sciences 2002;91(2):543-58.
2002: Carpenter John F; Chang Beyong S; Garzon-Rodriguez William; Randolph Theodore W
Rational design of stable lyophilized protein formulations: theory and practice.
Pharmaceutical biotechnology 2002;13():109-33.
2001: Stratton L P; Kelly R M; Rowe J; Shively J E; Smith D D; Carpenter J F; Manning M C
Controlling deamidation rates in a model peptide: effects of temperature, peptide concentration, and additives.
Journal of pharmaceutical sciences 2001;90(12):2141-8.
2001: Jones L S; Randolph T W; Kohnert U; Papadimitriou A; Winter G; Hagmann M L; Manning M C; Carpenter J F
The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution.
Journal of pharmaceutical sciences 2001;90(10):1466-77.
2001: Pikal-Cleland K A; Carpenter J F
Lyophilization-induced protein denaturation in phosphate buffer systems: monomeric and tetrameric beta-galactosidase.
Journal of pharmaceutical sciences 2001;90(9):1255-68.
2001: Searles J A; Carpenter J F; Randolph T W
Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine T(g)' in pharmaceutical lyophilization.
Journal of pharmaceutical sciences 2001;90(7):872-87.
2001: Searles J A; Carpenter J F; Randolph T W
The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf.
Journal of pharmaceutical sciences 2001;90(7):860-71.
2001: Webb J N; Webb S D; Cleland J L; Carpenter J F; Randolph T W
Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: high-pressure and cosolute studies on recombinant human IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7259-64.
2001: Anchordoquy T J; Izutsu K I; Randolph T W; Carpenter J F
Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying.
Archives of biochemistry and biophysics 2001;390(1):35-41.
2001: Cleland J L; Lam X; Kendrick B; Yang J; Yang T H; Overcashier D; Brooks D; Hsu C; Carpenter J F
A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody.
Journal of pharmaceutical sciences 2001;90(3):310-21.
2001: Nielsen L; Frokjaer S; Carpenter J F; Brange J
Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy.
Journal of pharmaceutical sciences 2001;90(1):29-37.
2001: Kim Y S; Cape S P; Chi E; Raffen R; Wilkins-Stevens P; Stevens F J; Manning M C; Randolph T W; Solomon A; Carpenter J F
Counteracting effects of renal solutes on amyloid fibril formation by immunoglobulin light chains.
The Journal of biological chemistry 2001;276(2):1626-33.
2000: Pikal-Cleland K A; Rodríguez-Hornedo N; Amidon G L; Carpenter J F
Protein denaturation during freezing and thawing in phosphate buffer systems: monomeric and tetrameric beta-galactosidase.
Archives of biochemistry and biophysics 2000;384(2):398-406.
2000: DePaz R A; Barnett C C; Dale D A; Carpenter J F; Gaertner A L; Randolph T W
The excluding effects of sucrose on a protein chemical degradation pathway: methionine oxidation in subtilisin.
Archives of biochemistry and biophysics 2000;384(1):123-32.
2000: Dong A; Meyer J D; Brown J L; Manning M C; Carpenter J F
Comparative fourier transform infrared and circular dichroism spectroscopic analysis of alpha1-proteinase inhibitor and ovalbumin in aqueous solution.
Archives of biochemistry and biophysics 2000;383(1):148-55.
2000: Yang T H; Cleland J L; Lam X; Meyer J D; Jones L S; Randolph T W; Manning M C; Carpenter J F
Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor.
Journal of pharmaceutical sciences 2000;89(11):1480-5.
2000: Dong A; Randolph T W; Carpenter J F
Entrapping intermediates of thermal aggregation in alpha-helical proteins with low concentration of guanidine hydrochloride.
The Journal of biological chemistry 2000;275(36):27689-93.
2000: Webb J N; Carpenter J F; Randolph T W
Stability of subtilisin and lysozyme under high hydrostatic pressure.
Biotechnology progress 2000;16(4):630-6.
2000: Lin J J; Meyer J D; Carpenter J F; Manning M C
Stability of human serum albumin during bioprocessing: denaturation and aggregation during processing of albumin paste.
Pharmaceutical research 2000;17(4):391-6.
2000: Allison S D; Manning M C; Randolph T W; Middleton K; Davis A; Carpenter J F
Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran.
Journal of pharmaceutical sciences 2000;89(2):199-214.
2000: Kim Y; Wall J S; Meyer J; Murphy C; Randolph T W; Manning M C; Solomon A; Carpenter J F
Thermodynamic modulation of light chain amyloid fibril formation.
The Journal of biological chemistry 2000;275(3):1570-4.
1999: St John R J; Carpenter J F; Randolph T W
High pressure fosters protein refolding from aggregates at high concentrations.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13029-33.
1999: Allison S D; Chang B; Randolph T W; Carpenter J F
Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.
Archives of biochemistry and biophysics 1999;365(2):289-98.
1999: Heller M C; Carpenter J F; Randolph T W
Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation.
Biotechnology and bioengineering 1999;63(2):166-74.
1999: Heller M C; Carpenter J F; Randolph T W
Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization.
Archives of biochemistry and biophysics 1999;363(2):191-201.
1999: Kreilgaard L; Frokjaer S; Flink J M; Randolph T W; Carpenter J F
Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid.
Journal of pharmaceutical sciences 1999;88(3):281-90.
1999: Yang T H; Dong A; Meyer J; Johnson O L; Cleland J L; Carpenter J F
Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres.
Journal of pharmaceutical sciences 1999;88(2):161-5.
1999: Heller M C; Carpenter J F; Randolph T W
Conformational stability of lyophilized PEGylated proteins in a phase-separating system.
Journal of pharmaceutical sciences 1999;88(1):58-64.
1999: Carpenter J F; Kendrick B S; Chang B S; Manning M C; Randolph T W
Inhibition of stress-induced aggregation of protein therapeutics.
Methods in enzymology 1999;309():236-55.
1998: Kreilgaard L; Jones L S; Randolph T W; Frokjaer S; Flink J M; Manning M C; Carpenter J F
Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII.
Journal of pharmaceutical sciences 1998;87(12):1597-603.
1998: Bam N B; Cleland J L; Yang J; Manning M C; Carpenter J F; Kelley R F; Randolph T W
Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions.
Journal of pharmaceutical sciences 1998;87(12):1554-9.
1998: Kreilgaard L; Frokjaer S; Flink J M; Randolph T W; Carpenter J F
Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid.
Archives of biochemistry and biophysics 1998;360(1):121-34.
1998: Li N; Kendrick B S; Manning M C; Carpenter J F; Duman J G
Secondary structure of antifreeze proteins from overwintering larvae of the beetle Dendroides canadensis.
Archives of biochemistry and biophysics 1998;360(1):25-32.
1998: Kendrick B S; Carpenter J F; Cleland J L; Randolph T W
A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14142-6.
1998: Allison S D; Randolph T W; Manning M C; Middleton K; Davis A; Carpenter J F
Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition.
Archives of biochemistry and biophysics 1998;358(1):171-81.
1998: Kendrick B S; Cleland J L; Lam X; Nguyen T; Randolph T W; Manning M C; Carpenter J F
Aggregation of recombinant human interferon gamma: kinetics and structural transitions.
Journal of pharmaceutical sciences 1998;87(9):1069-76.
1998: Anchordoquy T J; Girouard L G; Carpenter J F; Kroll D J
Stability of lipid/DNA complexes during agitation and freeze-thawing.
Journal of pharmaceutical sciences 1998;87(9):1046-51.
1998: Dong A; Matsuura J; Manning M C; Carpenter J F
Intermolecular beta-sheet results from trifluoroethanol-induced nonnative alpha-helical structure in beta-sheet predominant proteins: infrared and circular dichroism spectroscopic study.
Archives of biochemistry and biophysics 1998;355(2):275-81.
1998: Carpenter J F; Prestrelski S J; Dong A
Application of infrared spectroscopy to development of stable lyophilized protein formulations.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 1998;45(3):231-8.
1997: Anchordoquy T J; Carpenter J F; Kroll D J
Maintenance of transfection rates and physical characterization of lipid/DNA complexes after freeze-drying and rehydration.
Archives of biochemistry and biophysics 1997;348(1):199-206.
1997: Dong A; Kendrick B; Kreilgârd L; Matsuura J; Manning M C; Carpenter J F
Spectroscopic study of secondary structure and thermal denaturation of recombinant human factor XIII in aqueous solution.
Archives of biochemistry and biophysics 1997;347(2):213-20.
1997: Kendrick B S; Meyer J D; Matsuura J E; Carpenter J F; Manning M C
Hydrophobic ion pairing as a method for enhancing structure and activity of lyophilized subtilisin BPN' suspended in isooctane.
Archives of biochemistry and biophysics 1997;347(1):113-8.
1997: Kendrick B S; Chang B S; Arakawa T; Peterson B; Randolph T W; Manning M C; Carpenter J F
Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11917-22.
1997: Heller M C; Carpenter J F; Randolph T W
Manipulation of lyophilization-induced phase separation: implications for pharmaceutical proteins.
Biotechnology progress 1997;13(5):590-6.
1997: Stratton L P; Dong A; Manning M C; Carpenter J F
Drug delivery matrix containing native protein precipitates suspended in a poloxamer gel.
Journal of pharmaceutical sciences 1997;86(9):1006-10.
1997: Carpenter J F; Pikal M J; Chang B S; Randolph T W
Rational design of stable lyophilized protein formulations: some practical advice.
Pharmaceutical research 1997;14(8):969-75.
1997: Dong A; Kery V; Matsuura J; Manning M C; Kraus J P; Carpenter J F
Secondary structure of recombinant human cystathionine beta-synthase in aqueous solution: effect of ligand binding and proteolytic truncation.
Archives of biochemistry and biophysics 1997;344(1):125-32.
1997: Griffin K J; Dwyer T M; Manning M C; Meyer J D; Carpenter J F; Frerman F E
alphaT244M mutation affects the redox, kinetic, and in vitro folding properties of Paracoccus denitrificans electron transfer flavoprotein.
Biochemistry 1997;36(14):4194-202.
1996: Chang B S; Beauvais R M; Arakawa T; Narhi L O; Dong A; Aparisio D I; Carpenter J F
Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution.
Biophysical journal 1996;71(6):3399-406.
1996: Heller M C; Carpenter J F; Randolph T W
Effects of phase separating systems on lyophilized hemoglobin.
Journal of pharmaceutical sciences 1996;85(12):1358-62.
1996: Chang B S; Kendrick B S; Carpenter J F
Surface-induced denaturation of proteins during freezing and its inhibition by surfactants.
Journal of pharmaceutical sciences 1996;85(12):1325-30.
1996: Dong A; Meyer J D; Kendrick B S; Manning M C; Carpenter J F
Effect of secondary structure on the activity of enzymes suspended in organic solvents.
Archives of biochemistry and biophysics 1996;334(2):406-14.
1996: Allison S D; Dong A; Carpenter J F
Counteracting effects of thiocyanate and sucrose on chymotrypsinogen secondary structure and aggregation during freezing, drying, and rehydration.
Biophysical journal 1996;71(4):2022-32.
1996: Izutsu K; Yoshioka S; Kojima S; Randolph T W; Carpenter J F
Effects of sugars and polymers on crystallization of poly(ethylene glycol) in frozen solutions: phase separation between incompatible polymers.
Pharmaceutical research 1996;13(9):1393-400.
1996: Anchordoquy T J; Carpenter J F
Polymers protect lactate dehydrogenase during freeze-drying by inhibiting dissociation in the frozen state.
Archives of biochemistry and biophysics 1996;332(2):231-8.
1996: Chang B S; Beauvais R M; Dong A; Carpenter J F
Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation.
Archives of biochemistry and biophysics 1996;331(2):249-58.
1996: Chang B S; Reeder G; Carpenter J F
Development of a stable freeze-dried formulation of recombinant human interleukin-1 receptor antagonist.
Pharmaceutical research 1996;13(2):243-9.
1996: Kendrick B S; Dong A; Allison S D; Manning M C; Carpenter J F
Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states.
Journal of pharmaceutical sciences 1996;85(2):155-8.
1996: Dong A; Matsuura J; Allison S D; Chrisman E; Manning M C; Carpenter J F
Infrared and circular dichroism spectroscopic characterization of structural differences between beta-lactoglobulin A and B.
Biochemistry 1996;35(5):1450-7.
1995: Dong A; Prestrelski S J; Allison S D; Carpenter J F
Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation.
Journal of pharmaceutical sciences 1995;84(4):415-24.
1994: Vrkljan M; Foster T M; Powers M E; Henkin J; Porter W R; Staack H; Carpenter J F; Manning M C
Thermal stability of low molecular weight urokinase during heat treatment. II. Effect of polymeric additives.
Pharmaceutical research 1994;11(7):1004-8.
1993: Prestrelski S J; Tedeschi N; Arakawa T; Carpenter J F
Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers.
Biophysical journal 1993;65(2):661-71.
1993: Prestrelski S J; Arakawa T; Carpenter J F
Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy.
Archives of biochemistry and biophysics 1993;303(2):465-73.
1993: Carpenter J F; Prestrelski S J; Arakawa T
Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme activity and calorimetric studies.
Archives of biochemistry and biophysics 1993;303(2):456-64.
1992: Brockbank K G; Carpenter J F; Dawson P E
Effects of storage temperature on viable bioprosthetic heart valves.
Cryobiology 1992;29(5):537-42.
1991: Carpenter J F; Dawson P E
Quantitation of dimethyl sulfoxide in solutions and tissues by high-performance liquid chromatography.
Cryobiology 1991;28(3):210-5.
1991: Arakawa T; Kita Y; Carpenter J F
Protein--solvent interactions in pharmaceutical formulations.
Pharmaceutical research 1991;8(3):285-91.

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