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Timothy Wiltshire

Research Profile

Living Beings

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Daniel R Beisner; Ursula Bodendorf; Whitney Barnes; Benjamin Cravatt; Carol Dahlberg; Petra Langerak; Bruno Martoglio; Sherry Niessen; Francella J Otero; Albert E Parker; Laurent Poirot; Susan E Sutton; Timothy Wiltshire; Michael A Young; Michael P Cooke
The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.
Amy F Eisener-Dorman; Laura Grabowski-Boase; Salvador Huitron-Resendiz; Amanda J Roberts; Janice S Bailey; Timothy Wiltshire; Lisa M Tarantino
Characterization of Highper, an ENU-induced mouse mutant with abnormal psychostimulant and stress responses.
Cristina S Benton; Michael D Cameron; J S Marron; Brooke H Miller; Mathew T Pletcher; Laura E Schultz; Sean Skwerer; Oscar Suzuki; Timothy Wiltshire
Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains.

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2013: Daniel R Beisner; Ursula Bodendorf; Whitney Barnes; Benjamin Cravatt; Carol Dahlberg; Petra Langerak; Bruno Martoglio; Sherry Niessen; Francella J Otero; Albert E Parker; Laurent Poirot; Susan E Sutton; Timothy Wiltshire; Michael A Young; Michael P Cooke
The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.
The Journal of experimental medicine 2013;210(1):23-30.
2013: Amy F Eisener-Dorman; Laura Grabowski-Boase; Salvador Huitron-Resendiz; Amanda J Roberts; Janice S Bailey; Timothy Wiltshire; Lisa M Tarantino
Characterization of Highper, an ENU-induced mouse mutant with abnormal psychostimulant and stress responses.
Psychopharmacology 2013;225(2):407-19.
2012: Cristina S Benton; Michael D Cameron; J S Marron; Brooke H Miller; Mathew T Pletcher; Laura E Schultz; Sean Skwerer; Oscar Suzuki; Timothy Wiltshire
Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains.
Psychopharmacology 2012;221(2):297-315.
2012: Shiliang Wang; Timothy Wiltshire; Hua Zhang; Robert Sealock; James E Faber
Genetic dissection of the Canq1 locus governing variation in extent of the collateral circulation.
PloS one 2012;7(3):e31910.
2010: Scott A Kelly; Derrick L Nehrenberg; Jeremy L Peirce; Kunjie Hua; Brian M Steffy; Timothy Wiltshire; Fernando Pardo-Manuel de Villena; Theodore Garland; Daniel Pomp
Genetic architecture of voluntary exercise in an advanced intercross line of mice.
Physiological genomics 2010;42(2):190-200.
2010: Amy F Eisener-Dorman; Laura Grabowski-Boase; Brian M Steffy; Timothy Wiltshire; Lisa M Tarantino
Quantitative trait locus and haplotype mapping in closely related inbred strains identifies a locus for open field behavior.
Mammalian genome : official journal of the International Mammalian Genome Society 2010;21(5-6):231-46.
2010: Selina Elisabeth Ruth Bopp; Vandana Ramachandran; Kerstin Henson; Angelina Luzader; Merle Lindstrom; Muriel Spooner; Brian M Steffy; Oscar Suzuki; Chris Janse; Andrew P Waters; Yingyao Zhou; Timothy Wiltshire; Elizabeth A Winzeler
Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival.
PloS one 2010;5(5):e10903.
2010: Tejinder K Rakhra-Burris; Todd Auman; Patricia A Deverka; Lynn Dressler; James P Evans; Richard M Goldberg; Tammy M Havener; Janelle M Hoskins; Daniel Jonas; Kevin M Long; Alison A Motsinger-Reif; William Irvin; Kristy Richards; Mary Roederer; John M Valgus; Marcia van Riper; John Vernon; William C Zamboni; Michael J Wagner; Christine M Walko; Karen E Weck; Timothy Wiltshire; howard mcleod
Institutional profile. UNC Institute for Pharmacogenomics and Individualized Therapy: interdisciplinary research for individual care.
Pharmacogenomics 2010;11(1):13-21.
2009: Martin Schwander; Vanda Lopes; Anna Sczaniecka; Daniel Gibbs; Concepcion Lillo; David Delano; Lisa Tarantino; Timothy Wiltshire; David S Williams; Ulrich Müller
A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(50):15810-8.
2009: Camron D Bryant; H P Chang; J Zhang; Timothy Wiltshire; Lisa Tarantino; Abraham A Palmer
A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice.
Genes, brain, and behavior 2009;8(8):795-805.
2009: nicolas grillet; Martin Schwander; Michael S Hildebrand; Anna Sczaniecka; Anand Kolatkar; Janice Velasco; Jennifer A Webster; Kimia Kahrizi; Hossein Najmabadi; William J Kimberling; Dietrich A Stephan; Melanie Bahlo; Timothy Wiltshire; Lisa Tarantino; Peter Kuhn; Richard J H Smith; Ulrich Müller
Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans.
American journal of human genetics 2009;85(3):328-37.
2009: Alison Hege Harrill; Paul B Watkins; Stephen Su; Pamela K Ross; David E Harbourt; Ioannis M Stylianou; Gary A Boorman; Mark W Russo; Richard S Sackler; Stephen C Harris; Philip C Smith; Raymond Tennant; Molly Bogue; Kenneth Paigen; Christopher Harris; Tanupriya Contractor; Timothy Wiltshire; Ivan Rusyn; David Threadgill
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Genome research 2009;19(9):1507-15.
2009: Martin Schwander; Wei Xiong; Joshua Tokita; Andrea Lelli; Heather M Elledge; Piotr Kazmierczak; Anna Sczaniecka; Anand Kolatkar; Timothy Wiltshire; Peter Kuhn; Jeffrey R Holt; Anne E White-Olson; Lisa Tarantino; Ulrich Müller
A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5252-7.
2009: Rina Barouch-Bentov; Jianwei Che; Christian C Lee; Yating Yang; Ann Herman; Yong Jia; Anastasia Velentza; James Watson; Luise Sternberg; Sunjun Kim; Niusha Ziaee; Andrew Miller; Carie Jackson; Manabu Fujimoto; Mike Young; Serge Batalov; Yi Liu; Markus Warmuth; Timothy Wiltshire; Michael P Cooke; Karsten Sauer
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.
Molecular cell 2009;33(1):43-52.
2009: Richard Williams; Jackie E Lim; Bettina Harr; Claudia Wing; Ryan Walters; Margaret G Distler; Meike Teschke; Chunlei Wu; Timothy Wiltshire; Andrew Su; Greta Sokoloff; Lisa Tarantino; Justin O Borevitz; Abraham A Palmer
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior.
PloS one 2009;4(3):e4649.
2008: J S Bailey; L Grabowski-Boase; B M Steffy; Timothy Wiltshire; G A Churchill; Lisa Tarantino
Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains.
Genes, brain, and behavior 2008;7(7):761-9.
2008: Rainer Breitling; Yang Li; Bruno M Tesson; Jingyuan Fu; Chunlei Wu; Timothy Wiltshire; Alice Gerrits; Leonid V Bystrykh; Gerald de Haan; Andrew Su; Ritsert C Jansen
Genetical genomics: spotlight on QTL hotspots.
PLoS genetics 2008;4(10):e1000232.
2008: Reuben Howden; Eric Liu; Laura Miller-DeGraff; Heather L Keener; Christopher Walker; James A Clark; Page H Myers; D Clay Rouse; Timothy Wiltshire; Steven R Kleeberger
The genetic contribution to heart rate and heart rate variability in quiescent mice.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H59-68.
2008: Chunlei Wu; David L Delano; Nico Mitro; Stephen V Su; Jeff Janes; Phillip McClurg; Serge Batalov; Genevieve L Welch; Jie Zhang; Anthony P Orth; John R Walker; Richard J Glynne; Michael P Cooke; Joseph S Takahashi; Kazuhiro Shimomura; Akira Kohsaka; Joseph Bass; Enrique Saez; Timothy Wiltshire; Andrew Su
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
PLoS genetics 2008;4(5):e1000070.
2008: Yann Cheli; Deborah Jensen; Patrizia Marchese; David Habart; Timothy Wiltshire; Michael Cooke; José A Fernandez; Jerry Ware; Zaverio M Ruggeri; Thomas J Kunicki
The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice.
Blood 2008;111(3):1266-73.
2008: Stéphane Labialle; Lanjian Yang; Xuan Ruan; Aude Villemain; Jennifer Schmidt; Arturo Hernandez; Timothy Wiltshire; Nicolas Cermakian; Anna K Naumova
Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes.
Human molecular genetics 2008;17(1):15-26.
2007: Phillip McClurg; Jeff Janes; Chunlei Wu; David L Delano; John R Walker; Serge Batalov; Joseph S Takahashi; Kazuhiro Shimomura; Akira Kohsaka; Joseph Bass; Timothy Wiltshire; Andrew Su
Genomewide association analysis in diverse inbred mice: power and population structure.
Genetics 2007;176(1):675-83.
2007: Martin Schwander; Anna Sczaniecka; nicolas grillet; Janice Bailey; Matthew Avenarius; Hossein Najmabadi; Brian M Steffy; Glenn C Federe; Erica A Lagler; Raheleh Banan; Rudy Hice; Laura Grabowski-Boase; Elisabeth M Keithley; Allen F Ryan; Gary D Housley; Timothy Wiltshire; Richard J H Smith; Lisa Tarantino; Ulrich Müller
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(9):2163-75.
2006: John R Walker; Timothy Wiltshire
Databases of free expression.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(12):1141-6.
2006: Leon G Reijmers; Jennifer K Coats; Mathew Pletcher; Timothy Wiltshire; Lisa Tarantino; Mark Mayford
A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen.
Learning & memory (Cold Spring Harbor, N.Y.) 2006;13(2):143-9.
2006: Jennifer L Moran; Andrew D Bolton; Pamela V Tran; Alison Brown; Noelle D Dwyer; Danielle K Manning; Bryan Bjork; Cheng Li; Kate Montgomery; Sandra M Siepka; Martha Hotz Vitaterna; Joseph S Takahashi; Timothy Wiltshire; David J Kwiatkowski; Raju Kucherlapati; David Beier
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.
Genome research 2006;16(3):436-40.
2006: Koichi Tabeta; Kasper Hoebe; edith janssen; Xin Du; Philippe Georgel; Karine Crozat; Suzanne Mudd; Navjiwan Mann; Sosathya Sovath; Jason Goode; Louis Shamel; Anat Herskovits; Daniel A Portnoy; Michael Cooke; Lisa Tarantino; Timothy Wiltshire; Benjamin E Steinberg; Sergio Grinstein; Bruce Beutler
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Nature immunology 2006;7(2):156-64.
2006: Phillip McClurg; Mathew Pletcher; Timothy Wiltshire; Andrew Su
Comparative analysis of haplotype association mapping algorithms.
BMC bioinformatics 2006;7():61.
2006: Susanne Fries; Tilo Grosser; Thomas S Price; John A Lawson; Shiv Kapoor; Susan DeMarco; Mathew Pletcher; Timothy Wiltshire; garret fitzgerald
Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2.
Gastroenterology 2006;130(1):55-64.
2006: Naoki Ishimori; Renhua Li; Kenneth A Walsh; Ron Korstanje; Jarod Rollins; Petko M Petkov; Mathew Pletcher; Timothy Wiltshire; Leah Rae Donahue; Clifford J Rosen; Wesley G Beamer; Gary Churchill; Beverly Paigen
Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(1):105-12.
2005: David L Delano; M Carmen Montesinos; Avani Desai; Tuere Wilder; Patricia Fernandez; Peter D'Eustachio; Timothy Wiltshire; Bruce N Cronstein
Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation.
Arthritis and rheumatism 2005;52(8):2567-75.
2005: Sarah E Owens; Karl W Broman; Timothy Wiltshire; J Bradford Elmore; Kevin M Bradley; Jeffrey R Smith; E Michelle Southard-Smith
Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease.
Human molecular genetics 2005;14(11):1549-58.
2005: Leonid V Bystrykh; Ellen Weersing; Bert Dontje; Sue Sutton; Mathew Pletcher; Timothy Wiltshire; Andrew Su; Edo Vellenga; Jintao Wang; Kenneth F Manly; Lu Lu; Elissa J Chesler; Rudi Alberts; Ritsert C Jansen; Robert Williams; Michael P Cooke; Gerald de Haan
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.
Nature genetics 2005;37(3):225-32.
2005: David L Delano; M Carmen Montesinos; Peter D'Eustachio; Timothy Wiltshire; Bruce N Cronstein
An interaction between genetic factors and gender determines the magnitude of the inflammatory response in the mouse air pouch model of acute inflammation.
Inflammation 2005;29(1):1-7.
2005: Mark L Sandberg; Susan E Sutton; Mathew Pletcher; Timothy Wiltshire; Lisa Tarantino; John B Hogenesch; Michael P Cooke
c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation.
Developmental cell 2005;8(2):153-66.
2004: Mathew Pletcher; Phillip McClurg; Serge Batalov; Andrew Su; S Whitney Barnes; Erica Lagler; Ron Korstanje; Xiaosong Wang; Deborah Nusskern; Molly A Bogue; Richard J Mural; Beverly Paigen; Timothy Wiltshire
Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse.
PLoS biology 2004;2(12):e393.
2004: Gary Churchill; David C Airey; Hooman Allayee; Joe M Angel; Alan D Attie; Jackson Beatty; William D Beavis; John K Belknap; Beth Bennett; Wade Berrettini; Andre Bleich; Molly Bogue; Karl W Broman; Kari J Buck; Ed Buckler; Margit Burmeister; Elissa J Chesler; James M Cheverud; Steven Clapcote; Melloni N Cook; Roger D Cox; John C Crabbe; Wim Crusio; Ariel Darvasi; Christian Deschepper; R W Doerge; Charles Farber; Jiri Forejt; Daniel Gaile; Steven J Garlow; Hartmut Geiger; Howard Gershenfeld; Terry Gordon; Jing Gu; Weikuan Gu; Gerald de Haan; Nancy L Hayes; Craig Heller; Heinz Himmelbauer; Robert Hitzemann; Kent Hunter; Hui-Chen Hsu; Fuad A Iraqi; Boris Ivandic; Howard J Jacob; Ritsert C Jansen; Karl Jepsen; Dabney K Johnson; Thomas Johnson; Gerd Kempermann; Christina Kendziorski; Malak Kotb; R Frank Kooy; Bastien Llamas; Frank Lammert; Jean-Michel Lassalle; Pedro R Lowenstein; Lu Lu; Aldons Lusis; Kenneth F Manly; Ralph Marcucio; Doug Matthews; Juan F Medrano; Darla R Miller; Guy Mittleman; Beverly A Mock; Jeffrey S Mogil; Xavier Montagutelli; Grant Morahan; David G Morris; Richard Mott; Joseph H Nadeau; Hiroki Nagase; Richard Nowakowski; Bruce F O'Hara; Alexander V Osadchuk; Grier P Page; Beverly Paigen; Kenneth Paigen; Abraham A Palmer; Huei-Ju Pan; Leena Peltonen-Palotie; Jeremy Peirce; Daniel Pomp; Michal Pravenec; Daniel R Prows; Zhonghua Qi; Roger H Reeves; John Roder; Glenn D Rosen; Eric E Schadt; Leonard C Schalkwyk; Ze'ev Seltzer; Kazuhiro Shimomura; Siming Shou; Mikko J Sillanpää; Linda D Siracusa; Hans-Willem Snoeck; Jimmy Spearow; Karen Svenson; Lisa Tarantino; David Threadgill; Linda A Toth; William Valdar; Fernando Villena; Craig H Warden; Steve Whatley; Robert W Williams; Timothy Wiltshire; Nengjun Yi; Dabao Zhang; Min Zhang; Fei Zou
The Collaborative Cross, a community resource for the genetic analysis of complex traits.
Nature genetics 2004;36(11):1133-7.
2004: Andrew Su; Timothy Wiltshire; Serge Batalov; Hilmar Lapp; Keith A Ching; David Block; Jie Zhang; Richard Soden; Mimi Hayakawa; Gabriel Kreiman; Michael P Cooke; John R Walker; John B Hogenesch
A gene atlas of the mouse and human protein-encoding transcriptomes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6062-7.
2004: Ben G Wen; Mathew Pletcher; Masaki Warashina; Sun Hui Choe; Niusha Ziaee; Timothy Wiltshire; Karsten Sauer; Michael P Cooke
Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5604-9.
2004: Mathew Pletcher; Timothy Wiltshire
Can we find the genes involved in complex traits?
Genome biology 2004;5(10):347.
2003: Satchidananda Panda; Ignacio Provencio; Daniel C Tu; Susana Pires; Mark D Rollag; Ana Castrucci; Mathew Pletcher; Trey K Sato; Timothy Wiltshire; Mary Andahazy; Steve A Kay; Russell N Van Gelder; John B Hogenesch
Melanopsin is required for non-image-forming photic responses in blind mice.
Science (New York, N.Y.) 2003;301(5632):525-7.
2003: Timothy Wiltshire; Mathew Pletcher; Serge Batalov; S Whitney Barnes; Lisa Tarantino; Michael P Cooke; Hua Wu; Kevin Smylie; Andrey Santrosyan; Neal G Copeland; Nancy A Jenkins; Francis Kalush; Richard J Mural; Richard J Glynne; Steve A Kay; Mark D Adams; Colin F Fletcher
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3380-5.
2002: Andrew Su; Michael P Cooke; Keith A Ching; Yaron Hakak; John R Walker; Timothy Wiltshire; Anthony P Orth; Raquel G Vega; Lisa M Sapinoso; Aziz Moqrich; Ardem Patapoutian; Garret M Hampton; Peter G Schultz; John B Hogenesch
Large-scale analysis of the human and mouse transcriptomes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4465-70.
2001: Jonathan Crabtree; Timothy Wiltshire; Brian P Brunk; Shaying Zhao; Jonathan Schug; Christian J Stoeckert; Maja Bucan
High-resolution BAC-based map of the central portion of mouse chromosome 5.
Genome research 2001;11(10):1746-57.
2001: Mathew Pletcher; Timothy Wiltshire; Deborah E Cabin; Melissa P Villanueva; Roger H Reeves
Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.
Genomics 2001;74(1):45-54.
2000: Lisa Tarantino; Leonard Feiner; A Alavizadeh; Timothy Wiltshire; Belen Hurle; David M Ornitz; AL Webber; Jonathan A Raper; Andreas Lengeling; L B Rowe; Maja Bucan
A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5.
Genomics 2000;66(1):55-64.
2000: Eloisa S Moreira; Timothy Wiltshire; Georgine Faulkner; A Nilforoushan; Mariz Vainzof; Oscar T Suzuki; Georgio Valle; Roger H Reeves; Mayana Zatz; Maria Rita Passos-Bueno; D E Jenne
Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin.
Nature genetics 2000;24(2):163-6.
1999: Timothy Wiltshire; Mathew Pletcher; Susan Cole; Melissa P Villanueva; Bruce Birren; Jessica A Lehoczky; Ken Dewar; Roger H Reeves
Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21.
Genome research 1999;9(12):1214-22.
1999: Andreas Lengeling; Timothy Wiltshire; C Otmani; M Bucán
A sequence-ready BAC contig of the GABAA receptor gene cluster Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5.
Genome research 1999;9(8):732-8.
1999: Susan Cole; Timothy Wiltshire; EE Rue; D Morrow; P Hieter; C Brahe; E M Fisher; Nicholas Katsanis; Roger H Reeves
High-resolution comparative physical mapping of mouse chromosome 10 in the region of homology with human chromosome 21.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(3):229-34.
1998: Deborah E Cabin; J W McKee-Johnson; LE Matesic; Timothy Wiltshire; EE Rue; A E Mjaatvedt; Y K Huo; Julie R Korenberg; Roger H Reeves
Physical and comparative mapping of distal mouse chromosome 16. 5 p5.
Genome research 1998;8(9):940-50.
1998: Susan Cole; Timothy Wiltshire; Roger H Reeves
Physical mapping of the evolutionary boundary between human chromosomes 21 and 22 on mouse chromosome 10.
Genomics 1998;50(1):109-11.
1998: Y Fang; TS Spisz; Timothy Wiltshire; NP D'Costa; Issac Bankman; Roger H Reeves; Jan H Hoh
Solid-state DNA sizing by atomic force microscopy.
Analytical chemistry 1998;70(10):2123-9.