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Helen-Ann Brown Epstein

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James K Stoller; Robert Fallat; Mark D Schluchter; Ralph G O'Brien; Jason T Connor; Nicholas Gross; Kevin O'Neil; Robert Sandhaus; Helen-Ann Brown Epstein
Augmentation therapy with alpha1-antitrypsin: patterns of use and adverse events. 2003.
Robert J Kaner; Francisco Santiago; Helen-Ann Brown Epstein
Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema.
Maija Kiuru; Jason Solomon; Bassem Ghali; Marjolein van der Meulen; Helen-Ann Brown Epstein; Chisa Hidaka
Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone.

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All Publications

2009: James K Stoller; Robert Fallat; Mark D Schluchter; Ralph G O'Brien; Jason T Connor; Nicholas Gross; Kevin O'Neil; Robert Sandhaus; Helen-Ann Brown Epstein
Augmentation therapy with alpha1-antitrypsin: patterns of use and adverse events. 2003.
Chest 2009;136(5 Suppl):e30.
2009: Robert J Kaner; Francisco Santiago; Helen-Ann Brown Epstein
Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema.
Journal of leukocyte biology 2009;86(4):913-22.
2009: Maija Kiuru; Jason Solomon; Bassem Ghali; Marjolein van der Meulen; Helen-Ann Brown Epstein; Chisa Hidaka
Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(9):1598-607.
2009: Maija Kiuru; Chisa Hidaka; Ralf-Harto Hubner; Jason Solomon; Anja Krause; Philip L Leopold; Helen-Ann Brown Epstein
Sonic hedgehog expands diaphyseal trabecular bone altering bone marrow niche and lymphocyte compartment.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(8):1442-52.
2009: Ralf-Harto Hübner; Jamie D Schwartz; P De Bishnu; Barbara Ferris; Larsson Omberg; Jason G Mezey; Neil R Hackett; Helen-Ann Brown Epstein
Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking.
Molecular medicine (Cambridge, Mass.) 2009;15(7-8):203-19.
2009: Christine Tertilt; Ju Joh; Anja Krause; Paigee Chou; Kristin Schneeweiss; Helen-Ann Brown Epstein; Stefan Worgall
Expression of B-cell activating factor enhances protective immunity of a vaccine against Pseudomonas aeruginosa.
Infection and immunity 2009;77(7):3044-55.
2009: Masaki Watanabe; Julie L Boyer; Helen-Ann Brown Epstein
Genetic delivery of bevacizumab to suppress vascular endothelial growth factor-induced high-permeability pulmonary edema.
Human gene therapy 2009;20(6):598-610.
2009: Holly Vanni; Angeliki Kazeros; Rui Wang; Ben-Gary Harvey; Barbara Ferris; Bishnu P De; Brendan J Carolan; Ralf-Harto Hübner; Timothy P O'Connor; Helen-Ann Brown Epstein
Cigarette smoking induces overexpression of a fat-depleting gene AZGP1 in the human.
Chest 2009;135(5):1197-208.
2009: Maija Kiuru; Julie L Boyer; Timothy P O'Connor; Helen-Ann Brown Epstein
Genetic control of wayward pluripotent stem cells and their progeny after transplantation.
Cell stem cell 2009;4(4):289-300.
2009: Carolina Sofer-Podesta; John Ang; Neil R Hackett; Svetlana Senina; David Perlin; Helen-Ann Brown Epstein; Julie L Boyer
Adenovirus-mediated delivery of an anti-V antigen monoclonal antibody protects mice against a lethal Yersinia pestis challenge.
Infection and immunity 2009;77(4):1561-8.
2009: Ann E Tilley; Ben-Gary Harvey; Adriana Heguy; Neil R Hackett; Rui Wang; Timothy P O'Connor; Helen-Ann Brown Epstein
Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2009;179(6):457-66.
2009: Yuhu Song; Howard H Lou; Julie L Boyer; Maria P Limberis; Luk Vandenberghe; Neil R Hackett; Philip L Leopold; James M Wilson; Helen-Ann Brown Epstein
Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing.
Human gene therapy 2009;20(3):267-81.
2009: Ralf H Hubner; Philip L Leopold; Maija Kiuru; Bishnu P De; Anja Krause; Helen-Ann Brown Epstein
Dysfunctional glycogen storage in a mouse model of alpha1-antitrypsin deficiency.
American journal of respiratory cell and molecular biology 2009;40(2):239-47.
2009: Philip L Leopold; Michael J O'Mahony; X Julie Lian; Ann E Tilley; Ben-Gary Harvey; Helen-Ann Brown Epstein
Smoking is associated with shortened airway cilia.
PloS one 2009;4(12):e8157.
2009: Rui Wang; Helen-Ann Brown Epstein; Neil R Hackett
Identification of an exonic splicing silencer in exon 6A of the human VEGF gene.
BMC molecular biology 2009;10():103.
2009: Brendan J Carolan; Ben-Gary Harvey; Neil R Hackett; Timothy P O'Connor; Patricia A Cassano; Helen-Ann Brown Epstein
Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers.
Respiratory research 2009;10():111.
2009: Tina Raman; Timothy P O'Connor; Neil R Hackett; Wei Wang; Ben-Gary Harvey; Marc A Attiyeh; David T Dang; Matthew Teater; Helen-Ann Brown Epstein
Quality control in microarray assessment of gene expression in human airway epithelium.
BMC genomics 2009;10():493.
2008: Angeliki Kazeros; Ben-Gary Harvey; Brendan J Carolan; Holly Vanni; Anja Krause; Helen-Ann Brown Epstein
Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers.
American journal of respiratory cell and molecular biology 2008;39(6):747-57.
2008: Brendan J Carolan; Ben-Gary Harvey; Bishnu P De; Holly Vanni; Helen-Ann Brown Epstein
Decreased expression of intelectin 1 in the human airway epithelium of smokers compared to nonsmokers.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5760-7.
2008: Helen-Ann Brown Epstein; Scott H Randell; John F Engelhardt; Judith Voynow; Mary E Sunday
Airway epithelial cells: current concepts and challenges.
Proceedings of the American Thoracic Society 2008;5(7):772-7.
2008: Teri J Franks; Thomas V Colby; William D Travis; Rubin M Tuder; Herbert Y Reynolds; Arnold R Brody; Wellington Cardoso; Helen-Ann Brown Epstein; Christopher J Drake; John Engelhardt; Maria Frid; Erica Herzog; Robert Mason; Sem H Phan; Scott H Randell; Mary C Rose; Troy Stevens; Julie Serge; Mary E Sunday; Judith A Voynow; Brant M Weinstein; Jeffrey Whitsett; Mary C Williams
Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function.
Proceedings of the American Thoracic Society 2008;5(7):763-6.
2008: Dolan Sondhi; Daniel A Peterson; Andrew M Edelstein; Katrina del Fierro; Neil R Hackett; Helen-Ann Brown Epstein
Survival advantage of neonatal CNS gene transfer for late infantile neuronal ceroid lipofuscinosis.
Experimental neurology 2008;213(1):18-27.
2008: Davor Skaricic; Chani Traube; Bishnu De; Ju Joh; Julie Boyer; Helen-Ann Brown Epstein; Stefan Worgall
Genetic delivery of an anti-RSV antibody to protect against pulmonary infection with RSV.
Virology 2008;378(1):79-85.
2008: Zeinab Ammous; Neil R Hackett; Marcus W Butler; Tina Raman; Igor Dolgalev; Timothy P O'Connor; Ben-Gary Harvey; Helen-Ann Brown Epstein
Variability in small airway epithelial gene expression among normal smokers.
Chest 2008;133(6):1344-53.
2008: Stefan Worgall; Dolan Sondhi; Neil R Hackett; Barry Kosofsky; Minal V Kekatpure; Nurunisa Neyzi; Jonathan P Dyke; Douglas Ballon; Linda Heier; Bruce M Greenwald; Paul Christos; Madhu Mazumdar; Mark M Souweidane; Michael Gordon Kaplitt; Helen-Ann Brown Epstein
Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.
Human gene therapy 2008;19(5):463-74.
2008: Masaki Watanabe; Julie L Boyer; Neil R Hackett; Jianping Qiu; Helen-Ann Brown Epstein
Genetic delivery of the murine equivalent of bevacizumab (avastin), an anti-vascular endothelial growth factor monoclonal antibody, to suppress growth of human tumors in immunodeficient mice.
Human gene therapy 2008;19(3):300-10.
2008: M Kiuru; Helen-Ann Brown Epstein
Progress and prospects: gene therapy for performance and appearance enhancement.
Gene therapy 2008;15(5):329-37.
2008: Bishnu P De; Neil R Hackett; Helen-Ann Brown Epstein; Julie L Boyer
Rapid/sustained anti-anthrax passive immunity mediated by co-administration of Ad/AAV.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):203-9.
2007: Juyeon Jung; Neil R Hackett; Robert Pergolizzi; Lorraine Pierre-Destine; Anja Krause; Helen-Ann Brown Epstein
Ablation of tumor-derived stem cells transplanted to the central nervous system by genetic modification of embryonic stem cells with a suicide gene.
Human gene therapy 2007;18(12):1182-92.
2007: Stefan Worgall; Anja Krause; JianPing Qiu; Ju Joh; Neil R Hackett; Helen-Ann Brown Epstein
Protective immunity to pseudomonas aeruginosa induced with a capsid-modified adenovirus expressing P. aeruginosa OprF.
Journal of virology 2007;81(24):13801-8.
2007: Philip L Leopold; Helen-Ann Brown Epstein
Intracellular trafficking of adenovirus: many means to many ends.
Advanced drug delivery reviews 2007;59(8):810-21.
2007: Stefan Worgall; M V Kekatpure; Linda A Heier; Douglas Ballon; Jonathan P Dyke; Dikoma Shungu; Xiangling Mao; B Kosofsky; Michael Gordon Kaplitt; Mark M Souweidane; Dolan Sondhi; Neil R Hackett; C Hollmann; Helen-Ann Brown Epstein
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Neurology 2007;69(6):521-35.
2007: Jonathan P Dyke; Henning U Voss; Dolan Sondhi; Neil R Hackett; Stefan Worgall; Linda A Heier; B E Kosofsky; Aziz Ulug; Dikoma Shungu; Xiangling Mao; Helen-Ann Brown Epstein; Douglas Ballon
Assessing disease severity in late infantile neuronal ceroid lipofuscinosis using quantitative MR diffusion-weighted imaging.
AJNR. American journal of neuroradiology 2007;28(7):1232-6.
2007: Yael Strulovici; Philip L Leopold; Timothy P O'Connor; Robert Pergolizzi; Helen-Ann Brown Epstein
Human embryonic stem cells and gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):850-66.
2007: Adriana Heguy; Ben-Gary Harvey; Philip L Leopold; Igor Dolgalev; Tina Raman; Helen-Ann Brown Epstein
Responses of the human airway epithelium transcriptome to in vivo injury.
Physiological genomics 2007;29(2):139-48.
2007: Dolan Sondhi; Neil R Hackett; Daniel A Peterson; Jamie Stratton; Michael Baad; Kelly M Travis; James M Wilson; Helen-Ann Brown Epstein
Enhanced survival of the LINCL mouse following CLN2 gene transfer using the rh.10 rhesus macaque-derived adeno-associated virus vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(3):481-91.
2007: Brian D Gelbman; Adriana Heguy; Timothy P O'Connor; Joseph Zabner; Helen-Ann Brown Epstein
Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis.
Respiratory research 2007;8():10.
2007: Hiroyasu Kobayashi; Stefan Worgall; Timothy P O'Connor; Helen-Ann Brown Epstein
Interaction of Pneumocystis carinii with dendritic cells and resulting host responses to P. carinii.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(1):54-63.
2007: Ben-Gary Harvey; Adriana Heguy; Philip L Leopold; Brendan J Carolan; Barbara Ferris; Helen-Ann Brown Epstein
Modification of gene expression of the small airway epithelium in response to cigarette smoking.
Journal of molecular medicine (Berlin, Germany) 2007;85(1):39-53.
2006: Brendan J Carolan; Adriana Heguy; Ben-Gary Harvey; Philip L Leopold; Barbara Ferris; Helen-Ann Brown Epstein
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
Cancer research 2006;66(22):10729-40.
2006: Maria J Chiuchiolo; Julie L Boyer; Anja Krause; Svetlana Senina; Neil R Hackett; Helen-Ann Brown Epstein
Protective immunity against respiratory tract challenge with Yersinia pestis in mice immunized with an adenovirus-based vaccine vector expressing V antigen.
The Journal of infectious diseases 2006;194(9):1249-57.
2006: Philip L Leopold; Rebecca L Wendland; Theresa Vincent; Helen-Ann Brown Epstein
Neutralized adenovirus-immune complexes can mediate effective gene transfer via an Fc receptor-dependent infection pathway.
Journal of virology 2006;80(20):10237-47.
2006: Samir Kelkar; Bishnu P De; Guangping Gao; James M Wilson; Helen-Ann Brown Epstein; Philip L Leopold
A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes.
Journal of virology 2006;80(15):7781-5.
2006: Robert Pergolizzi; Guangchun Jin; Diane Chan; Lorraine Pierre; James Bussel; Barbara Ferris; Philip L Leopold; Helen-Ann Brown Epstein
Correction of a murine model of von Willebrand disease by gene transfer.
Blood 2006;108(3):862-9.
2006: Anja Krause; Ju H Joh; Neil R Hackett; Peter W Roelvink; Joseph T Bruder; Thomas J Wickham; Imre Kovesdi; Helen-Ann Brown Epstein; Stefan Worgall
Epitopes expressed in different adenovirus capsid proteins induce different levels of epitope-specific immunity.
Journal of virology 2006;80(11):5523-30.
2006: David K Jin; Koji Shido; Hans-Georg Kopp; Isabelle Petit; Sergey V Shmelkov; Lauren M Young; Andrea T Hooper; Hideki Amano; Scott T Avecilla; Beate Heissig; Koichi Hattori; Fan Zhang; Daniel J Hicklin; Yan Wu; Zhenping Zhu; Ashley Dunn; Hassan Salari; Zena Werb; Neil R Hackett; Helen-Ann Brown Epstein; David Lyden; Shahin Rafii
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes.
Nature medicine 2006;12(5):557-67.
2006: Toshiaki Fushimi; Timothy P O'Connor; Helen-Ann Brown Epstein
Adenoviral gene transfer of stromal cell-derived factor-1 to murine tumors induces the accumulation of dendritic cells and suppresses tumor growth.
Cancer research 2006;66(7):3513-22.
2006: Timothy P O'Connor; Helen-Ann Brown Epstein
Genetic medicines: treatment strategies for hereditary disorders.
Nature reviews. Genetics 2006;7(4):261-76.
2006: Adriana Heguy; Timothy P O'Connor; Karsta Luettich; Stefan Worgall; Adam Cieciuch; Ben-Gary Harvey; Neil R Hackett; Helen-Ann Brown Epstein
Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking.
Journal of molecular medicine (Berlin, Germany) 2006;84(4):318-28.
2006: Marco A Passini; James C Dodge; Jie Bu; Wendy Yang; Qi Zhao; Dolan Sondhi; Neil R Hackett; Stephen M Kaminsky; Qinwen Mao; Lamya S Shihabuddin; Seng Cheng; David E Sleat; Gregory R Stewart; Beverly L Davidson; Peter Lobel; Helen-Ann Brown Epstein
Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(5):1334-42.
2006: Julie L Boyer; Helen-Ann Brown Epstein
Genetic medicine strategies to protect against bioterrorism.
Transactions of the American Clinical and Climatological Association 2006;117():297-310; discussion 310-1.
2006: Bishnu P De; Adriana Heguy; Neil R Hackett; Barbara Ferris; Philip L Leopold; John Lee; Lorraine Pierre; Guangping Gao; James M Wilson; Helen-Ann Brown Epstein
High levels of persistent expression of alpha1-antitrypsin mediated by the nonhuman primate serotype rh.10 adeno-associated virus despite preexisting immunity to common human adeno-associated viruses.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(1):67-76.
2005: Neil R Hackett; D Eugene Redmond; Dolan Sondhi; E Lela Giannaris; Elizabeth Vassallo; Jamie Stratton; Jianping Qiu; Stephen M Kaminsky; Martin L Lesser; Gene S Fisch; Serge D Rouselle; Helen-Ann Brown Epstein
Safety of direct administration of AAV2(CU)hCLN2, a candidate treatment for the central nervous system manifestations of late infantile neuronal ceroid lipofuscinosis, to the brain of rats and nonhuman primates.
Human gene therapy 2005;16(12):1484-503.
2005: Masahiro Mae; Timothy P O'Connor; Helen-Ann Brown Epstein
Gene transfer of the vascular endothelial growth factor receptor flt-1 suppresses pulmonary metastasis associated with lung growth.
American journal of respiratory cell and molecular biology 2005;33(6):629-35.
2005: Dolan Sondhi; D A Peterson; E Lela Giannaris; C T Sanders; B S Mendez; B De; A B Rostkowski; Barbara C Blanchard; Kimberly B Bjugstad; John R Sladek; D Eugene Redmond; Philip L Leopold; Stephen M Kaminsky; Neil R Hackett; Helen-Ann Brown Epstein
AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL.
Gene therapy 2005;12(22):1618-32.
2005: Pierre Feugier; Na Li; Deog-Yeon Jo; Jae-Hung Shieh; Karen L MacKenzie; J F Lesesve; Véronique Latger-Cannard; Danièle Bensoussan; Helen-Ann Brown Epstein; Shahin Rafii; J F Stoltz; Malcolm A S Moore
Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro.
Stem cells and development 2005;14(5):505-16.
2005: Adriana Heguy; Helen-Ann Brown Epstein
Intrapleural 'outside-in' gene therapy: therapeutics for organs of the chest via gene transfer to the pleura.
Current opinion in molecular therapeutics 2005;7(5):440-53.
2005: Masahiko Hashimoto; Julie L Boyer; Neil R Hackett; James M Wilson; Helen-Ann Brown Epstein
Induction of protective immunity to anthrax lethal toxin with a nonhuman primate adenovirus-based vaccine in the presence of preexisting anti-human adenovirus immunity.
Infection and immunity 2005;73(10):6885-91.
2005: Hideki Amano; Neil R Hackett; Robert J Kaner; Paul Whitlock; Todd K Rosengart; Helen-Ann Brown Epstein
Alteration of splicing signals in a genomic/cDNA hybrid VEGF gene to modify the ratio of expressed VEGF isoforms enhances safety of angiogenic gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):716-24.
2005: Lisa M Arkin; Dolan Sondhi; Stefan Worgall; Lily Hyon K Suh; Neil R Hackett; Stephen M Kaminsky; Syed A Hosain; Mark M Souweidane; Michael Gordon Kaplitt; Jonathan P Dyke; Linda A Heier; Douglas Ballon; Dikoma Shungu; Krystyna E Wisniewski; Bruce M Greenwald; Charleen Hollmann; Helen-Ann Brown Epstein
Confronting the issues of therapeutic misconception, enrollment decisions, and personal motives in genetic medicine-based clinical research studies for fatal disorders.
Human gene therapy 2005;16(9):1028-36.
2005: Howard Lou; Helen-Ann Brown Epstein; Philip L Leopold
Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):575-8.
2005: Hideki Amano; Neil R Hackett; Shahin Rafii; Helen-Ann Brown Epstein
Thrombopoietin gene transfer-mediated enhancement of angiogenic responses to acute ischemia.
Circulation research 2005;97(4):337-45.
2005: Stefan Worgall; Adriana Heguy; Karsta Luettich; Timothy P O'Connor; Ben-Gary Harvey; Luis E N Quadri; Helen-Ann Brown Epstein
Similarity of gene expression patterns in human alveolar macrophages in response to Pseudomonas aeruginosa and Burkholderia cepacia.
Infection and immunity 2005;73(8):5262-8.
2005: Xunrong Luo; Hua Yang; Il Soo Kim; Fludd Saint-Hilaire; Dolca A Thomas; Bishnu P De; Engin Ozkaynak; Thangamani Muthukumar; Wayne W Hancock; Helen-Ann Brown Epstein; Manikkam Suthanthiran
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.
Transplantation 2005;79(9):1091-6.
2005: Fan Zhang; Joseph Cheng; George Lam; David K Jin; Loïc Vincent; Neil R Hackett; Shiyang Wang; Lauren M Young; Barbara L Hempstead; Helen-Ann Brown Epstein; Shahin Rafii
Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways.
Circulation research 2005;96(9):950-7.
2005: Stefan Worgall; Anja Krause; Michael Rivara; Kyung-Kim Hee; Enrico V Vintayen; Neil R Hackett; Peter W Roelvink; Joseph T Bruder; Thomas J Wickham; Imre Kovesdi; Helen-Ann Brown Epstein
Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid.
The Journal of clinical investigation 2005;115(5):1281-9.
2005: Robert Pergolizzi; Rachel Dragos; Alexander E Ropper; André Menez; Helen-Ann Brown Epstein
Protective immunity against alpha-cobratoxin following a single administration of a genetic vaccine encoding a non-toxic cobratoxin variant.
Human gene therapy 2005;16(3):292-8.
2005: Pouneh Kermani; Dahlia Rafii; David K Jin; Paul Whitlock; Wendy Lynn Schaffer; Anne Chiang; Loïc Vincent; Matthias Friedrich; Koji Shido; Neil R Hackett; Helen-Ann Brown Epstein; Shahin Rafii; Barbara L Hempstead
Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors.
The Journal of clinical investigation 2005;115(3):653-63.
2005: Julie L Boyer; Gary P Kobinger; James M Wilson; Helen-Ann Brown Epstein
Adenovirus-based genetic vaccines for biodefense.
Human gene therapy 2005;16(2):157-68.
2005: Kazuhiko Kasuya; Julie L Boyer; Yadi Tan; D Olivier Alipui; Neil R Hackett; Helen-Ann Brown Epstein
Passive immunotherapy for anthrax toxin mediated by an adenovirus expressing an anti-protective antigen single-chain antibody.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(2):237-44.
2005: Katsutoshi Nakayama; Robert Pergolizzi; Helen-Ann Brown Epstein
Gene transfer-mediated pre-mRNA segmental trans-splicing as a strategy to deliver intracellular toxins for cancer therapy.
Cancer research 2005;65(1):254-63.
2004: Bishnu De; Adriana Heguy; Philip L Leopold; Nabil Wasif; Robert J Korst; Neil R Hackett; Helen-Ann Brown Epstein
Intrapleural administration of a serotype 5 adeno-associated virus coding for alpha1-antitrypsin mediates persistent, high lung and serum levels of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1003-10.
2004: Helen-Ann Brown Epstein; Dolan Sondhi; Neil R Hackett; Stephen M Kaminsky; Stefan Worgall; Philip E Stieg; Mark M Souweidane; Syed A Hosain; Linda A Heier; Douglas Ballon; Miles Dinner; Krystyna Wisniewski; Michael Gordon Kaplitt; Bruce M Greenwald; Joy D Howell; Kristin Strybing; Jonathan P Dyke; Henning U Voss
Clinical protocol. Administration of a replication-deficient adeno-associated virus gene transfer vector expressing the human CLN2 cDNA to the brain of children with late infantile neuronal ceroid lipofuscinosis.
Human gene therapy 2004;15(11):1131-54.
2004: Paul Schalch; Gerald Patejunas; Mauricio A Retuerto; Sorin Sarateanu; Jeffrey Milbrandt; Geeta Thakker; David Kim; JoAnn Carbray; Helen-Ann Brown Epstein; Todd K Rosengart
Homozygous deletion of early growth response 1 gene and critical limb ischemia after vascular ligation in mice: evidence for a central role in vascular homeostasis.
The Journal of thoracic and cardiovascular surgery 2004;128(4):595-601.
2004: Robert E Merritt; Reiko E Yamada; Nabil Wasif; Helen-Ann Brown Epstein; Robert J Korst
Effect of inhibition of multiple steps of angiogenesis in syngeneic murine pleural mesothelioma.
The Annals of thoracic surgery 2004;78(3):1042-51; discussion 1042-51.
2004: Samir A Kelkar; K Kevin Pfister; Helen-Ann Brown Epstein; Philip L Leopold
Cytoplasmic dynein mediates adenovirus binding to microtubules.
Journal of virology 2004;78(18):10122-32.
2004: Robert Pergolizzi; Helen-Ann Brown Epstein
Genetic medicine at the RNA level: modifications of the genetic repertoire for therapeutic purposes by pre-mRNA trans-splicing.
Comptes rendus biologies 2004;327(8):695-709.
2004: Minoru Tahara; Robert Pergolizzi; Hiroyasu Kobayashi; Anja Krause; Karsta Luettich; Martin L Lesser; Helen-Ann Brown Epstein
Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency.
Nature medicine 2004;10(8):835-41.
2004: Theresa Vincent; Ralf F Pettersson; Helen-Ann Brown Epstein; Philip L Leopold
Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells.
Journal of virology 2004;78(15):8047-58.
2004: Mauricio A Retuerto; Paul Schalch; Gerald Patejunas; JoAnn Carbray; Naxin Liu; Karyn Esser; Helen-Ann Brown Epstein; Todd K Rosengart
Angiogenic pretreatment improves the efficacy of cellular cardiomyoplasty performed with fetal cardiomyocyte implantation.
The Journal of thoracic and cardiovascular surgery 2004;127(4):1041-9; discussion 1049-51.
2004: Fan Zhang; Joseph Cheng; Neil R Hackett; George Lam; Koji Shido; Robert Pergolizzi; David K Jin; Helen-Ann Brown Epstein; Shahin Rafii
Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin/Akt signaling pathway.
The Journal of biological chemistry 2004;279(12):11760-6.
2004: Stefan Worgall; Annette Busch; Michael Rivara; David Bonnyay; Philip L Leopold; Robert Merritt; Neil R Hackett; Peter W Rovelink; Joseph T Bruder; Thomas J Wickham; Imre Kovesdi; Helen-Ann Brown Epstein
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Journal of virology 2004;78(5):2572-80.
2004: Paul Schalch; G Farah Rahman; Gerald Patejunas; Robert A Goldschmidt; JoAnn Carbray; Mauricio A Retuerto; David Kim; Karyn Esser; Helen-Ann Brown Epstein; Todd K Rosengart
Adenoviral-mediated transfer of vascular endothelial growth factor 121 cDNA enhances myocardial perfusion and exercise performance in the nonischemic state.
The Journal of thoracic and cardiovascular surgery 2004;127(2):535-40.
2004: Robert E Merritt; Reiko E Yamada; Helen-Ann Brown Epstein; Robert J Korst
Augmenting major histocompatibility complex class I expression by murine tumors in vivo enhances antitumor immunity induced by an active immunotherapy strategy.
The Journal of thoracic and cardiovascular surgery 2004;127(2):355-64.
2004: Robert J Kaner; Helen-Ann Brown Epstein
Pathogenesis of high altitude pulmonary edema: does alveolar epithelial lining fluid vascular endothelial growth factor exacerbate capillary leak?
High altitude medicine & biology 2004;5(4):399-409.
2004: Paul Whitlock; Neil R Hackett; Philip L Leopold; Todd K Rosengart; Helen-Ann Brown Epstein
Adenovirus-mediated transfer of a minigene expressing multiple isoforms of VEGF is more effective at inducing angiogenesis than comparable vectors expressing individual VEGF cDNAs.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):67-75.
2004: Scott T Avecilla; Koichi Hattori; Beate Heissig; Rafael Tejada; Fang Liao; Koji Shido; David K Jin; Sergio Dias; Fan Zhang; Travis E Hartman; Neil R Hackett; Helen-Ann Brown Epstein; Larry Witte; Daniel J Hicklin; Peter Bohlen; Dan Eaton; David Lyden; Frederic J de Sauvage; Shahin Rafii
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.
Nature medicine 2004;10(1):64-71.
2003: Robert Pergolizzi; Alexander E Ropper; Rachel Dragos; Alicia C Reid; Katsutoshi Nakayama; Yadi Tan; John R Ehteshami; Struhan H Coleman; Randi B Silver; Neil R Hackett; André Menez; Helen-Ann Brown Epstein
In vivo trans-splicing of 5' and 3' segments of pre-mRNA directed by corresponding DNA sequences delivered by gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(6):999-1008.
2003: Yadi Tan; Neil R Hackett; Julie L Boyer; Helen-Ann Brown Epstein
Protective immunity evoked against anthrax lethal toxin after a single intramuscular administration of an adenovirus-based vaccine encoding humanized protective antigen.
Human gene therapy 2003;14(17):1673-82.
2003: Robert E Merritt; Ali Mahtabifard; Reiko E Yamada; Helen-Ann Brown Epstein; Robert J Korst
Cisplatin augments cytotoxic T-lymphocyte-mediated antitumor immunity in poorly immunogenic murine lung cancer.
The Journal of thoracic and cardiovascular surgery 2003;126(5):1609-17.
2003: Fan Zhang; Neil R Hackett; George Lam; Joseph Cheng; Robert Pergolizzi; Lan Luo; Sergey V Shmelkov; Jay M Edelberg; Helen-Ann Brown Epstein; Shahin Rafii
Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells.
Blood 2003;102(6):2115-21.
2003: Adriana Heguy; Ben-Gary Harvey; Timothy P O'Connor; Neil R Hackett; Helen-Ann Brown Epstein
Sampling-dependent up-regulation of gene expression in sequential samples of human airway epithelial cells.
Molecular medicine (Cambridge, Mass.) 2003;9(9-12):200-8.
2003: Neil R Hackett; Adriana Heguy; Ben-Gary Harvey; Timothy P O'Connor; Karsta Luettich; Douglas B Flieder; Rana Kaplan; Helen-Ann Brown Epstein
Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers.
American journal of respiratory cell and molecular biology 2003;29(3 Pt 1):331-43.
2003: Ali Mahtabifard; Robert E Merritt; Reiko E Yamada; Helen-Ann Brown Epstein; Robert J Korst
In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies.
The Journal of thoracic and cardiovascular surgery 2003;126(1):28-38.
2003: Rana Kaplan; Karsta Luettich; Adriana Heguy; Neil R Hackett; Ben-Gary Harvey; Helen-Ann Brown Epstein
Monoallelic up-regulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers.
Cancer research 2003;63(7):1475-82.
2003: Jay M Lee; Robert E Merritt; Ali Mahtabifard; Reiko Yamada; Toshiaki Kikuchi; Helen-Ann Brown Epstein; Robert J Korst
Intratumoral expression of macrophage-derived chemokine induces CD4+ T cell-independent antitumor immunity in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2003;26(2):117-29.
2002: Jay M Lee; Ali Mahtabifard; Reiko Yamada; Helen-Ann Brown Epstein; Robert J Korst
Adenovirus vector-mediated overexpression of a truncated form of the p65 nuclear factor kappa B cDNA in dendritic cells enhances their function resulting in immune-mediated suppression of preexisting murine tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3561-9.
2002: Stefan Worgall; Katherine Martushova; Annette Busch; Leah Lande; Helen-Ann Brown Epstein
Apoptosis induced by Pseudomonas aeruginosa in antigen presenting cells is diminished by genetic modification with CD40 ligand.
Pediatric research 2002;52(5):636-44.
2002: Masahiro Mae; Helen-Ann Brown Epstein
Gene transfer to the pleural mesothelium as a strategy to deliver proteins to the lung parenchyma.
Human gene therapy 2002;13(12):1471-82.
2002: Harvey Ben-Gary; Robin L McKinney; Todd K Rosengart; Martin L Lesser; Helen-Ann Brown Epstein
Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):287-97.
2002: Joshua Rice; Ruth I Connor; Stefan Worgall; John P Moore; Philip L Leopold; Robert J Kaner; Helen-Ann Brown Epstein
Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors.
American journal of respiratory cell and molecular biology 2002;27(2):214-9.
2002: Koichi Hattori; Beate Heissig; Yan Wu; Sergio Dias; Rafael Tejada; Barbara Ferris; Daniel J Hicklin; Zhenping Zhu; Peter Bohlen; Larry Witte; Jan Hendrikx; Neil R Hackett; Helen-Ann Brown Epstein; Malcolm A S Moore; Zena Werb; David Lyden; Shahin Rafii
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.
Nature medicine 2002;8(8):841-9.
2002: Helen-Ann Brown Epstein; Peter B Bitterman; Brooke Mossman; Marvin I Schwarz; Dean Sheppard; Laura A Almasy; Harold A Chapman; Scott L Friedman; Talmadge E King; Leslie A Leinwand; Lance Liotta; George R Martin; David A Schwartz; Gregory Schultz; Carston R Wagner; Robert A Musson
Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.
American journal of respiratory and critical care medicine 2002;166(2):236-46.
2002: Beate Heissig; Koichi Hattori; Sergio Dias; Matthias Friedrich; Barbara Ferris; Neil R Hackett; Helen-Ann Brown Epstein; Peter Besmer; David Lyden; Malcolm A S Moore; Zena Werb; Shahin Rafii
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.
Cell 2002;109(5):625-37.
2002: Robert J Korst; Ali Mahtabifard; Reiko Yamada; Helen-Ann Brown Epstein
Effect of adenovirus gene transfer vectors on the immunologic functions of mouse dendritic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):307-15.
2002: Chisa Hidaka; Clemente Ibarra; Jo A Hannafin; Peter A Torzilli; Mannix Quitoriano; Shih-Shi Jen; Russell F Warren; Helen-Ann Brown Epstein
Formation of vascularized meniscal tissue by combining gene therapy with tissue engineering.
Tissue engineering 2002;8(1):93-105.
2002: Maneesh Ailawadi; Jay M Lee; Sang Lee; Neil R Hackett; Helen-Ann Brown Epstein; Robert J Korst
Adenovirus vector-mediated transfer of the vascular endothelial growth factor cDNA to healing abdominal fascia enhances vascularity and bursting strength in mice with normal and impaired wound healing.
Surgery 2002;131(2):219-27.
2002: Pierre Feugier; Deog-Yeon Jo; Jae-Hung Shieh; Karen L MacKenzie; Shahin Rafii; Helen-Ann Brown Epstein; Malcolm A S Moore
Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand.
Journal of hematotherapy & stem cell research 2002;11(1):127-38.
2002: Helen-Ann Brown Epstein; Ben-Gary Harvey; Juan P Wisnivesky; Kelley A O'Donoghue; Karen W Chu; Jaman Maroni; Jolene C Muscat; Allison L Pippo; Connie E Wright; Robert J Kaner; Philip L Leopold; Paul D Kessler; Henrik S Rasmussen; Todd K Rosengart; Charleen Hollmann
Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions.
Human gene therapy 2002;13(1):65-100.
2002: Ben-Gary Harvey; Jaman Maroni; Kelley A O'Donoghue; Karen W Chu; Jolene C Muscat; Allison L Pippo; Connie E Wright; Charleen Hollmann; Juan P Wisnivesky; Paul D Kessler; Henrik S Rasmussen; Todd K Rosengart; Helen-Ann Brown Epstein
Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions.
Human gene therapy 2002;13(1):15-63.
2001: Noboru Sato; Philip L Leopold; Helen-Ann Brown Epstein
Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia.
Journal of the National Cancer Institute 2001;93(24):1858-64.
2001: A Kianmanesh; Neil R Hackett; J M Lee; T Kikuchi; R J Korst; Helen-Ann Brown Epstein
Intratumoral administration of low doses of an adenovirus vector encoding tumor necrosis factor alpha together with naive dendritic cells elicits significant suppression of tumor growth without toxicity.
Human gene therapy 2001;12(17):2035-49.
2001: Dolan Sondhi; Neil R Hackett; R L Apblett; Stephen M Kaminsky; Robert Pergolizzi; Helen-Ann Brown Epstein
Feasibility of gene therapy for late neuronal ceroid lipofuscinosis.
Archives of neurology 2001;58(11):1793-8.
2001: David Lyden; K Hattori; Sergio Dias; C Costa; Pamela Blaikie; Linda J Butros; Amy Chadburn; Beate Heissig; W Marks; Larry Witte; Y Wu; Daniel J Hicklin; Z Zhu; Neil R Hackett; Helen-Ann Brown Epstein; Malcolm A S Moore; K A Hajjar; Katia Manova-Todorova; Robert Benezra; Shahin Rafii
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth.
Nature medicine 2001;7(11):1194-201.
2001: L J Landesberg; R Ramalingam; K Lee; T K Rosengart; Helen-Ann Brown Epstein
Upregulation of transcription factors in lung in the early phase of postpneumonectomy lung growth.
American journal of physiology. Lung cellular and molecular physiology 2001;281(5):L1138-49.
2001: Y Tong; W Song; Helen-Ann Brown Epstein
Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors.
Cancer research 2001;61(20):7530-5.
2001: T Kikuchi; Helen-Ann Brown Epstein
Antigen-pulsed dendritic cells expressing macrophage-derived chemokine elicit Th2 responses and promote specific humoral immunity.
The Journal of clinical investigation 2001;108(6):917-27.
2001: Robert J Korst; Maneesh Ailawadi; Jay M Lee; Sang Lee; Reiko Yamada; Ali Mahtabifard; Helen-Ann Brown Epstein
Adenovirus gene transfer vectors inhibit growth of lymphatic tumor metastases independent of a therapeutic transgene.
Human gene therapy 2001;12(13):1639-49.
2001: M A Seidman; S M Hogan; R L Wendland; Stefan Worgall; Helen-Ann Brown Epstein; Philip L Leopold
Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(1):13-21.
2001: T Kikuchi; Neil R Hackett; Helen-Ann Brown Epstein
Cross-strain protection against clinical and laboratory strains of Pseudomonas aeruginosa mediated by dendritic cells genetically modified to express CD40 ligand and pulsed with specific strains of Pseudomonas aeruginosa.
Human gene therapy 2001;12(10):1251-63.
2001: Stefan Worgall; T Kikuchi; R Singh; Katherine Martushova; L Lande; Helen-Ann Brown Epstein
Protection against pulmonary infection with Pseudomonas aeruginosa following immunization with P. aeruginosa-pulsed dendritic cells.
Infection and immunity 2001;69(7):4521-7.
2001: Malcolm A S Moore; K Hattori; Beate Heissig; Jae-Hung Shieh; Sergio Dias; Helen-Ann Brown Epstein; Shahin Rafii
Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1.
Annals of the New York Academy of Sciences 2001;938():36-45; discussion 45-7.
2001: K Hattori; Beate Heissig; K Tashiro; T Honjo; M Tateno; Jae-Hung Shieh; Neil R Hackett; M S Quitoriano; Helen-Ann Brown Epstein; Shahin Rafii; Malcolm A S Moore
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells.
Blood 2001;97(11):3354-60.
2001: Robert J Kaner; Helen-Ann Brown Epstein
Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung.
Molecular medicine (Cambridge, Mass.) 2001;7(4):240-6.
2001: Ben-Gary Harvey; Neil R Hackett; Scott Ely; Helen-Ann Brown Epstein
Host responses and persistence of vector genome following intrabronchial administration of an E1(-)E3(-) adenovirus gene transfer vector to normal individuals.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(2):206-15.
2001: Theresa Vincent; Ben-Gary Harvey; S M Hogan; C J Bailey; Helen-Ann Brown Epstein; Philip L Leopold
Rapid assessment of adenovirus serum neutralizing antibody titer based on quantitative, morphometric evaluation of capsid binding and intracellular trafficking: population analysis of adenovirus capsid association with cells is predictive of adenovirus infectivity.
Journal of virology 2001;75(3):1516-21.
2001: N Miyazawa; Helen-Ann Brown Epstein; Philip L Leopold
Adenovirus serotype 7 retention in a late endosomal compartment prior to cytosol escape is modulated by fiber protein.
Journal of virology 2001;75(3):1387-400.
2001: W van't Hof; Helen-Ann Brown Epstein
Manipulation of the cytoplasmic and transmembrane domains alters cell surface levels of the coxsackie-adenovirus receptor and changes the efficiency of adenovirus infection.
Human gene therapy 2001;12(1):25-34.
2000: W Song; Y Tong; H Carpenter; HL Kong; Helen-Ann Brown Epstein
Persistent, antigen-specific, therapeutic antitumor immunity by dendritic cells genetically modified with an adenoviral vector to express a model tumor antigen.
Gene therapy 2000;7(24):2080-6.
2000: Neil R Hackett; T El-Sawy; L Y Lee; Ivan Silva; J O'Leary; Todd K Rosengart; Helen-Ann Brown Epstein
Use of quantitative TaqMan real-time PCR to track the time-dependent distribution of gene transfer vectors in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(6):649-56.
2000: T Kikuchi; N Miyazawa; Malcolm A S Moore; Helen-Ann Brown Epstein
Tumor regression induced by intratumor administration of adenovirus vector expressing CD40 ligand and naive dendritic cells.
Cancer research 2000;60(22):6391-5.
2000: R Ramalingam; Stefan Worgall; Shahin Rafii; Helen-Ann Brown Epstein
Downregulation of CXCR4 gene expression in primary human endothelial cells following infection with E1(-)E4(+) adenovirus gene transfer vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(4):381-6.
2000: T Kikuchi; Stefan Worgall; R Singh; Malcolm A S Moore; Helen-Ann Brown Epstein
Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells.
Nature medicine 2000;6(10):1154-9.
2000: Neil R Hackett; Stephen M Kaminsky; Dolan Sondhi; Helen-Ann Brown Epstein
Antivector and antitransgene host responses in gene therapy.
Current opinion in molecular therapeutics 2000;2(4):376-82.
2000: Karen L MacKenzie; Neil R Hackett; Helen-Ann Brown Epstein; Malcolm A S Moore
Adenoviral vector-mediated gene transfer to primitive human hematopoietic progenitor cells: assessment of transduction and toxicity in long-term culture.
Blood 2000;96(1):100-8.
2000: T Kikuchi; Malcolm A S Moore; Helen-Ann Brown Epstein
Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors.
Blood 2000;96(1):91-9.
2000: Robert J Kaner; J V Ladetto; R Singh; N Fukuda; Michael A Matthay; Helen-Ann Brown Epstein
Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema.
American journal of respiratory cell and molecular biology 2000;22(6):657-64.
2000: T Fushimi; A Kojima; Malcolm A S Moore; Helen-Ann Brown Epstein
Macrophage inflammatory protein 3alpha transgene attracts dendritic cells to established murine tumors and suppresses tumor growth.
The Journal of clinical investigation 2000;105(10):1383-93.
2000: DM Labow; Sang Lee; Robert J Ginsberg; Helen-Ann Brown Epstein; Robert J Korst
Adenovirus vector-mediated gene transfer to regional lymph nodes.
Human gene therapy 2000;11(5):759-69.
2000: DC Cipolla; Igor Gonda; S Shak; Imre Kovesdi; Helen-Ann Brown Epstein; T D Sweeney
Coarse spray delivery to a localized region of the pulmonary airways for gene therapy.
Human gene therapy 2000;11(2):361-71.
2000: Stefan Worgall; T S Worgall; K Kostarelos; R Singh; Philip L Leopold; Neil R Hackett; Helen-Ann Brown Epstein
Free cholesterol enhances adenoviral vector gene transfer and expression in CAR-deficient cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(1):39-48.
2000: Leonard Y Lee; SR Patel; Neil R Hackett; Charles A Mack; DR Polce; T El-Sawy; R Hachamovitch; Pat Zanzonico; Timothy A Sanborn; Manish Parikh; O Wayne Isom; Helen-Ann Brown Epstein; Todd K Rosengart
Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121.
The Annals of thoracic surgery 2000;69(1):14-23; discussion 23-4.
2000: Philip L Leopold; Geri Kreitzer; N Miyazawa; S Rempel; K Kevin Pfister; Enrique Rodriguez-Boulan; Helen-Ann Brown Epstein
Dynein- and microtubule-mediated translocation of adenovirus serotype 5 occurs after endosomal lysis.
Human gene therapy 2000;11(1):151-65.
1999: R Ramalingam; Shahin Rafii; Stefan Worgall; Neil R Hackett; Helen-Ann Brown Epstein
Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vector.
Journal of virology 1999;73(12):10183-90.
1999: Ben-Gary Harvey; Stefan Worgall; Scott Ely; Philip L Leopold; Helen-Ann Brown Epstein
Cellular immune responses of healthy individuals to intradermal administration of an E1-E3- adenovirus gene transfer vector.
Human gene therapy 1999;10(17):2823-37.
1999: P Bezdicek; Stefan Worgall; Imre Kovesdi; M K Kim; J G Park; Theresa Vincent; Philip L Leopold; Alan D Schreiber; Helen-Ann Brown Epstein
Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcgammaRIIA cDNA to the liver.
Blood 1999;94(10):3448-55.
1999: Edward A Hirschowitz; Hassan A Naama; DA Evoy; Michael D Lieberman; J Daly; Helen-Ann Brown Epstein
Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma.
Cancer gene therapy 1999;6(6):491-8.
1999: Ben-Gary Harvey; Philip L Leopold; Neil R Hackett; T M Grasso; P M Williams; A L Tucker; Robert J Kaner; Barbara Ferris; Igor Gonda; T D Sweeney; R Ramalingam; Imre Kovesdi; S Shak; Helen-Ann Brown Epstein
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.
The Journal of clinical investigation 1999;104(9):1245-55.
1999: Noboru Sato; Philip L Leopold; Helen-Ann Brown Epstein
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog.
The Journal of clinical investigation 1999;104(7):855-64.
1999: Juan P Wisnivesky; Philip L Leopold; Helen-Ann Brown Epstein
Specific binding of the adenovirus capsid to the nuclear envelope.
Human gene therapy 1999;10(13):2187-95.
1999: Stefan Worgall; P Bezdicek; M K Kim; J G Park; R Singh; Melpo Christofidou-Solomidou; A Prince; Imre Kovesdi; Alan D Schreiber; Helen-Ann Brown Epstein
Augmentation of pulmonary host defense against Pseudomonas by FcgammaRIIA cDNA transfer to the respiratory epithelium.
The Journal of clinical investigation 1999;104(4):409-18.
1999: Ben-Gary Harvey; Neil R Hackett; T El-Sawy; Todd K Rosengart; Edward A Hirschowitz; Michael D Lieberman; M L Lesser; Helen-Ann Brown Epstein
Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs.
Journal of virology 1999;73(8):6729-42.
1999: Leonard Y Lee; X Zhou; DR Polce; T El-Sawy; SR Patel; Geeta Thakker; K Narumi; Helen-Ann Brown Epstein; Todd K Rosengart
Exogenous control of cardiac gene therapy: evidence of regulated myocardial transgene expression after adenovirus and adeno-associated virus transfer of expression cassettes containing corticosteroid response element promoters.
The Journal of thoracic and cardiovascular surgery 1999;118(1):26-4, discussion 34-5.
1999: N Miyazawa; Philip L Leopold; Neil R Hackett; Barbara Ferris; Stefan Worgall; E Falck-Pedersen; Helen-Ann Brown Epstein
Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors.
Journal of virology 1999;73(7):6056-65.
1999: Stefan Worgall; Ruth I Connor; Robert J Kaner; E Fenamore; K Sheridan; R Singh; Helen-Ann Brown Epstein
Expression and use of human immunodeficiency virus type 1 coreceptors by human alveolar macrophages.
Journal of virology 1999;73(7):5865-74.
1999: T Kikuchi; Helen-Ann Brown Epstein
Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells.
Human gene therapy 1999;10(8):1375-87.
1999: SR Patel; Leonard Y Lee; Charles A Mack; DR Polce; T El-Sawy; Neil R Hackett; A Ilercil; E C Jones; Rebecca T Hahn; O Wayne Isom; Todd K Rosengart; Helen-Ann Brown Epstein
Safety of direct myocardial administration of an adenovirus vector encoding vascular endothelial growth factor 121.
Human gene therapy 1999;10(8):1331-48.
1999: Edward A Hirschowitz; Helen-Ann Brown Epstein
Adenovirus-mediated expression of interleukin-12 induces natural killer cell activity and complements adenovirus-directed gp75 treatment of melanoma lung metastases.
American journal of respiratory cell and molecular biology 1999;20(5):935-41.
1999: R Ramalingam; Shahin Rafii; Stefan Worgall; D E Brough; Helen-Ann Brown Epstein
E1(-)E4(+) adenoviral gene transfer vectors function as a "pro-life" signal to promote survival of primary human endothelial cells.
Blood 1999;93(9):2936-44.
1999: Robert J Kaner; Stefan Worgall; Philip L Leopold; E Stolze; E Milano; Chisa Hidaka; R Ramalingam; Neil R Hackett; R Singh; Jeffrey M Bergelson; RW Finberg; E Falck-Pedersen; Helen-Ann Brown Epstein
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
American journal of respiratory cell and molecular biology 1999;20(3):361-70.
1999: Chisa Hidaka; E Milano; Philip L Leopold; Jeffrey M Bergelson; Neil R Hackett; RW Finberg; Thomas J Wickham; Imre Kovesdi; Peter W Roelvink; Helen-Ann Brown Epstein
CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.
The Journal of clinical investigation 1999;103(4):579-87.
1999: Stefan Worgall; R Singh; Philip L Leopold; Robert J Kaner; Neil R Hackett; N Topf; Malcolm A S Moore; Helen-Ann Brown Epstein
Selective expansion of alveolar macrophages in vivo by adenovirus-mediated transfer of the murine granulocyte-macrophage colony-stimulating factor cDNA.
Blood 1999;93(2):655-66.
1998: K Narumi; A Kojima; Helen-Ann Brown Epstein
Adenovirus vector-mediated perforin expression driven by a glucocorticoid-inducible promoter inhibits tumor growth in vivo.
American journal of respiratory cell and molecular biology 1998;19(6):936-41.
1998: B M Frey; Shahin Rafii; Helen-Ann Brown Epstein; Malcolm A S Moore
[Adenovirus long-term expression of thrombopoietin in vivo: a new model for myeloproliferative syndrome and osteomyelofibrosis].
Schweizerische medizinische Wochenschrift 1998;128(42):1587-92.
1998: A Kojima; Neil R Hackett; Helen-Ann Brown Epstein
Reversal of CPT-11 resistance of lung cancer cells by adenovirus-mediated gene transfer of the human carboxylesterase cDNA.
Cancer research 1998;58(19):4368-74.
1998: K Narumi; M Suzuki; W Song; Malcolm A S Moore; Helen-Ann Brown Epstein
Intermittent, repetitive corticosteroid-induced upregulation of platelet levels after adenovirus-mediated transfer to the liver of a chimeric glucocorticoid-responsive promoter controlling the thrombopoietin cDNA.
Blood 1998;92(3):822-33.
1998: Edward A Hirschowitz; S Leonard; W Song; Barbara Ferris; Philip L Leopold; Jonathan J Lewis; Wilbur B Bowne; S Wang; Alan N Houghton; Helen-Ann Brown Epstein
Adenovirus-mediated expression of melanoma antigen gp75 as immunotherapy for metastatic melanoma.
Gene therapy 1998;5(7):975-83.
1998: M Suzuki; R Singh; Malcolm A S Moore; WR Song; Helen-Ann Brown Epstein
Similarity of strain- and route-dependent murine responses to an adenovirus vector using the homologous thrombopoietin cDNA as the reporter genes.
Human gene therapy 1998;9(8):1223-31.
1998: A Kojima; Neil R Hackett; A Ohwada; Helen-Ann Brown Epstein
In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors.
The Journal of clinical investigation 1998;101(8):1789-96.
1998: B M Frey; Neil R Hackett; J M Bergelson; R Finberg; Helen-Ann Brown Epstein; Malcolm A S Moore; Shahin Rafii
High-efficiency gene transfer into ex vivo expanded human hematopoietic progenitors and precursor cells by adenovirus vectors.
Blood 1998;91(8):2781-92.
1998: HL Kong; D Hecht; W Song; Imre Kovesdi; Neil R Hackett; A Yayon; Helen-Ann Brown Epstein
Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor.
Human gene therapy 1998;9(6):823-33.
1998: N Topf; Stefan Worgall; Neil R Hackett; Helen-Ann Brown Epstein
Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma.
Gene therapy 1998;5(4):507-13.
1998: Charles A Mack; CJ Magovern; KT Budenbender; SR Patel; E A Schwarz; Pat Zanzonico; B Ferris; Timothy A Sanborn; P Isom; B Ferris; T Sanborn; O Wayne Isom; Helen-Ann Brown Epstein; Todd K Rosengart
Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion.
Journal of vascular surgery 1998;27(4):699-709.
1998: HL Kong; Helen-Ann Brown Epstein
Gene therapy strategies for tumor antiangiogenesis.
Journal of the National Cancer Institute 1998;90(4):273-86.
1998: Philip L Leopold; Barbara Ferris; I Grinberg; Stefan Worgall; Neil R Hackett; Helen-Ann Brown Epstein
Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells.
Human gene therapy 1998;9(3):367-78.
1998: B M Frey; Shahin Rafii; M Teterson; D Eaton; Helen-Ann Brown Epstein; Malcolm A S Moore
Adenovector-mediated expression of human thrombopoietin cDNA in immune-compromised mice: insights into the pathophysiology of osteomyelofibrosis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):691-9.
1998: Charles A Mack; SR Patel; E A Schwarz; Pat Zanzonico; Rebecca T Hahn; A Ilercil; Richard B Devereux; S J Goldsmith; T F Christian; Timothy A Sanborn; Imre Kovesdi; Neil R Hackett; O Wayne Isom; Helen-Ann Brown Epstein; Todd K Rosengart
Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart.
The Journal of thoracic and cardiovascular surgery 1998;115(1):168-76; discussion 176-7.
1997: M Suzuki; R N Singh; Helen-Ann Brown Epstein
Ability of a chimeric cAMP-responsive promoter to confer pharmacologic control of CFTR cDNA expression and cAMP-mediated Cl- secretion.
Gene therapy 1997;4(11):1195-201.
1997: K Abrahamsen; H L Kong; A Mastrangeli; Douglas E Brough; A Lizonova; Helen-Ann Brown Epstein; E Falck-Pedersen
Construction of an adenovirus type 7a E1A- vector.
Journal of virology 1997;71(11):8946-51.
1997: W Song; HL Kong; H Carpenter; H Torii; Richard D Granstein; Shahin Rafii; Malcolm A S Moore; Helen-Ann Brown Epstein
Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity.
The Journal of experimental medicine 1997;186(8):1247-56.
1997: Roberto Pili; J Chang; J Muhlhauser; Helen-Ann Brown Epstein; Maurizio C Capogrossi; Antonino Passaniti
Adenovirus-mediated gene transfer of fibroblast growth factor-1: angiogenesis and tumorigenicity in nude mice.
International journal of cancer. Journal international du cancer 1997;73(2):258-63.
1997: Stefan Worgall; Philip L Leopold; Gerhard Wolff; Barbara Ferris; N Van Roijen; Helen-Ann Brown Epstein
Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract.
Human gene therapy 1997;8(14):1675-84.
1997: W Song; HL Kong; P Traktman; Helen-Ann Brown Epstein
Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors.
Human gene therapy 1997;8(10):1207-17.
1997: HM Ross; Edward A Hirschowitz; T J Russi; Helen-Ann Brown Epstein; S Nawata; ME Burt; Murray F Brennan; Jonathan J Lewis
Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo.
The Journal of surgical research 1997;70(1):7-11.
1997: S J Cannizzo; B M Frey; S Raffi; Malcolm A S Moore; D Eaton; M Suzuki; R Singh; Charles A Mack; Helen-Ann Brown Epstein
Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA.
Nature biotechnology 1997;15(6):570-3.
1997: Helen-Ann Brown Epstein; Edward A Hirschowitz; M Lieberman; J Daly; E Kazam; C Henschke; David Yankelevitz; Nancy Kemeny; R Silverstein; A Ohwada; T Russi; A Mastrangeli; A Sanders; J Cooke; Ben-Gary Harvey
Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.
Human gene therapy 1997;8(8):985-1001.
1997: DA Evoy; Edward A Hirschowitz; Hassan A Naama; X K Li; Helen-Ann Brown Epstein; John M Daly; Michael D Lieberman
In vivo adenoviral-mediated gene transfer in the treatment of pancreatic cancer.
The Journal of surgical research 1997;69(1):226-31.
1997: T J Russi; Edward A Hirschowitz; Helen-Ann Brown Epstein
Delayed-type hypersensitivity response to high doses of adenoviral vectors.
Human gene therapy 1997;8(3):323-30.
1997: CJ Magovern; Charles A Mack; J Zhang; Todd K Rosengart; O Wayne Isom; Helen-Ann Brown Epstein
Regional angiogenesis induced in nonischemic tissue by an adenoviral vector expressing vascular endothelial growth factor.
Human gene therapy 1997;8(2):215-27.
1997: Charles A Mack; WR Song; H Carpenter; Thomas J Wickham; Imre Kovesdi; Ben-Gary Harvey; CJ Magovern; O Wayne Isom; Todd K Rosengart; E Falck-Pedersen; Neil R Hackett; Helen-Ann Brown Epstein; A Mastrangeli
Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype.
Human gene therapy 1997;8(1):99-109.
1997: Stefan Worgall; Gerhard Wolff; E Falck-Pedersen; Helen-Ann Brown Epstein
Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.
Human gene therapy 1997;8(1):37-44.
1997: Gerhard Wolff; Stefan Worgall; Nico van Rooijen; WR Song; Ben-Gary Harvey; Helen-Ann Brown Epstein
Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.
Journal of virology 1997;71(1):624-9.
1996: STEVEN ROSENBERG; R. Michael Blaese; M K Brenner; A B Deisseroth; F D Ledley; M T Lotze; J M Wilson; Gary Nabel; Kenneth Cornetta; J S Economou; SM Freeman; S R Riddell; E Oldfield; B Gansbacher; Cynthia Dunbar; Robert E Walker; F G Schuening; J A Roth; Helen-Ann Brown Epstein; M J Welsh; KW Culver; H E Heslop; J Simons; R W Wilmott; P Tiberghien
Human gene marker/therapy clinical protocols.
Human gene therapy 1996;7(18):2287-313.
1996: Brian C O'Connell; T Xu; THOMAS WALSH; T Sein; A Mastrangeli; Helen-Ann Brown Epstein; F G Oppenheim; Bruce J Baum
Transfer of a gene encoding the anticandidal protein histatin 3 to salivary glands.
Human gene therapy 1996;7(18):2255-61.
1996: M Suzuki; R N Singh; Helen-Ann Brown Epstein
Regulatable promoters for use in gene therapy applications: modification of the 5'-flanking region of the CFTR gene with multiple cAMP response elements to support basal, low-level gene expression that can be upregulated by exogenous agents that raise intracellular levels of cAMP.
Human gene therapy 1996;7(15):1883-93.
1996: STEVEN ROSENBERG; R. Michael Blaese; M K Brenner; A B Deisseroth; F D Ledley; M T Lotze; J M Wilson; Gary Nabel; Kenneth Cornetta; J S Economou; SM Freeman; S R Riddell; E Oldfield; B Gansbacher; Cynthia Dunbar; Robert E Walker; F G Schuening; J A Roth; Helen-Ann Brown Epstein; M J Welsh; KW Culver; H E Heslop; J Simons; R W Wilmott; P Aebischer
Human gene marker/therapy clinical protocols.
Human gene therapy 1996;7(13):1621-47.
1996: A Ohwada; Edward A Hirschowitz; Helen-Ann Brown Epstein
Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.
Human gene therapy 1996;7(13):1567-76.
1996: A Ohwada; Shahin Rafii; Malcolm A S Moore; Helen-Ann Brown Epstein
In vivo adenovirus vector-mediated transfer of the human thrombopoietin cDNA maintains platelet levels during radiation-and chemotherapy-induced bone marrow suppression.
Blood 1996;88(3):778-84.
1996: CJ Magovern; Charles A Mack; J Zhang; Rebecca T Hahn; Wilson Ko; O Wayne Isom; Helen-Ann Brown Epstein; Todd K Rosengart
Direct in vivo gene transfer to canine myocardium using a replication-deficient adenovirus vector.
The Annals of thoracic surgery 1996;62(2):425-33; discussion 433-4.
1996: Gerhard Wolff; A Mastrangeli; M Heinflink; E Falck-Pedersen; Marvin C Gershengorn; Helen-Ann Brown Epstein
Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH.
Nature genetics 1996;12(3):274-9.
1996: RP Wersto; E R Rosenthal; Helen-Ann Brown Epstein; Kenneth R Spring
Uptake of fluorescent dyes associated with the functional expression of the cystic fibrosis transmembrane conductance regulator in epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1167-72.
1996: J Mühlhauser; M Jones; I Yamada; corrado cirielli; Patricia Lemarchand; T R Gloe; B Bewig; Sabina Signoretti; Helen-Ann Brown Epstein; Maurizio C Capogrossi
Safety and efficacy of in vivo gene transfer into the porcine heart with replication-deficient, recombinant adenovirus vectors.
Gene therapy 1996;3(2):145-53.
1996: A Mastrangeli; Ben-Gary Harvey; J Yao; Gerhard Wolff; Imre Kovesdi; Helen-Ann Brown Epstein; E Falck-Pedersen
"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype.
Human gene therapy 1996;7(1):79-87.
1996: C Danel; S C Erzurum; Noel G McElvaney; Helen-Ann Brown Epstein
Quantitative assessment of the epithelial and inflammatory cell populations in large airways of normals and individuals with cystic fibrosis.
American journal of respiratory and critical care medicine 1996;153(1):362-8.
1995: J Mühlhauser; Marsha J Merrill; Roberto Pili; H Maeda; M Bacic; B Bewig; Antonino Passaniti; N A Edwards; Helen-Ann Brown Epstein; Maurizio C Capogrossi
VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo.
Circulation research 1995;77(6):1077-86.
1995: J G Hay; Noel G McElvaney; J Herena; Helen-Ann Brown Epstein
Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector.
Human gene therapy 1995;6(11):1487-96.
1995: J Mühlhauser; Roberto Pili; Marsha J Merrill; H Maeda; Antonino Passaniti; Helen-Ann Brown Epstein; Maurizio C Capogrossi
In vivo angiogenesis induced by recombinant adenovirus vectors coding either for secreted or nonsecreted forms of acidic fibroblast growth factor.
Human gene therapy 1995;6(11):1457-65.
1995: Helen-Ann Brown Epstein
Transfer of genes to humans: early lessons and obstacles to success.
Science (New York, N.Y.) 1995;270(5235):404-10.
1995: Edward A Hirschowitz; A Ohwada; W R Pascal; T J Russi; Helen-Ann Brown Epstein
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine.
Human gene therapy 1995;6(8):1055-63.
1995: Helen-Ann Brown Epstein; A Mastrangeli; A Sanders; J Cooke; T King; F Gilbert; C Henschke; W Pascal; J Herena; Ben-Gary Harvey
Evaluation of repeat administration of a replication deficient, recombinant adenovirus containing the normal cystic fibrosis transmembrane conductance regulator cDNA to the airways of individuals with cystic fibrosis.
Human gene therapy 1995;6(5):667-703.
1995: Helen-Ann Brown Epstein; H Ari Jaffe; S Brody; A Mastrangeli; Noel G McElvaney; M Rosenfeld; C S Chu; C Danel; J Hay; T Eissa
A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung.
Human gene therapy 1995;6(5):643-66.
1995: J G Hay; C Danel; C S Chu; Helen-Ann Brown Epstein
Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease.
The American journal of physiology 1995;268(4 Pt 1):L565-75.
1995: W Siegfried; M Rosenfeld; L Stier; L Stratford-Perricaudet; M Perricaudet; A Pavirani; J P Lecocq; Helen-Ann Brown Epstein
Polarity of secretion of alpha 1-antitrypsin by human respiratory epithelial cells after adenoviral transfer of a human alpha 1-antitrypsin cDNA.
American journal of respiratory cell and molecular biology 1995;12(4):379-84.
1995: R J Korst; B Bewig; Helen-Ann Brown Epstein
In vitro and in vivo transfer and expression of human surfactant SP-A- and SP-B-associated protein cDNAs mediated by replication-deficient, recombinant adenoviral vectors.
Human gene therapy 1995;6(3):277-87.
1995: J Hersh; Helen-Ann Brown Epstein; B Bewig
Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.
Gene therapy 1995;2(2):124-31.
1995: A Miyashita; Helen-Ann Brown Epstein; J G Hay
Identification of a 27 bp 5'-flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene.
Nucleic acids research 1995;23(2):293-301.
1994: Y Setoguchi; C Danel; Helen-Ann Brown Epstein
Stimulation of erythropoiesis by in vivo gene therapy: physiologic consequences of transfer of the human erythropoietin gene to experimental animals using an adenovirus vector.
Blood 1994;84(9):2946-53.
1994: R J Guzman; E A Hirschowitz; S L Brody; Helen-Ann Brown Epstein; Stephen E Epstein; TOREN FINKEL
In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10732-6.
1994: N Kobayashi; E R Rosenthal; K Yoshimura; Helen-Ann Brown Epstein
Transfer of a constitutive viral promoter-cystic fibrosis transmembrane conductance regulator cDNA to human epithelial cells conveys resistance to down-regulation of cAMP-regulated Cl- secretion in the presence of inflammatory stimuli.
Nucleic acids research 1994;22(21):4470-6.
1994: K Yoshimura; C S Chu; Helen-Ann Brown Epstein
Enhancer function of a 53-bp repetitive element in the 5' flanking region of the human neutrophil elastase gene.
Biochemical and biophysical research communications 1994;204(1):38-42.
1994: S K Han; S L Brody; Helen-Ann Brown Epstein
Suppression of in vivo tumorigenicity of human lung cancer cells by retrovirus-mediated transfer of the human tumor necrosis factor-alpha cDNA.
American journal of respiratory cell and molecular biology 1994;11(3):270-8.
1994: N Tony Eissa; C S Chu; C Danel; Helen-Ann Brown Epstein
Evaluation of the respiratory epithelium of normals and individuals with cystic fibrosis for the presence of adenovirus E1a sequences relevant to the use of E1a- adenovirus vectors for gene therapy for the respiratory manifestations of cystic fibrosis.
Human gene therapy 1994;5(9):1105-14.
1994: M A Rosenfeld; Stephen Rosenfeld; C Danel; T C Banks; Helen-Ann Brown Epstein
Increasing expression of the normal human CFTR cDNA in cystic fibrosis epithelial cells results in a progressive increase in the level of CFTR protein expression, but a limit on the level of cAMP-stimulated chloride secretion.
Human gene therapy 1994;5(9):1121-9.
1994: Helen-Ann Brown Epstein; Noel G McElvaney; M A Rosenfeld; C S Chu; A Mastrangeli; J G Hay; S L Brody; H Ari Jaffe; N Tony Eissa; C Danel
Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis.
Nature genetics 1994;8(1):42-51.
1994: M Maruyama; J G Hay; K Yoshimura; C S Chu; Helen-Ann Brown Epstein
Modulation of secretory leukoprotease inhibitor gene expression in human bronchial epithelial cells by phorbol ester.
The Journal of clinical investigation 1994;94(1):368-75.
1994: P Birrer; Noel G McElvaney; A Rüdeberg; C W Sommer; S Liechti-Gallati; R Kraemer; R Hubbard; Helen-Ann Brown Epstein
Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.
American journal of respiratory and critical care medicine 1994;150(1):207-13.
1994: S L Brody; Mark E Metzger; C Danel; M A Rosenfeld; Helen-Ann Brown Epstein
Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA.
Human gene therapy 1994;5(7):821-36.
1994: A Mastrangeli; B O'Connell; W Aladib; P C Fox; B J Baum; Helen-Ann Brown Epstein
Direct in vivo adenovirus-mediated gene transfer to salivary glands.
The American journal of physiology 1994;266(6 Pt 1):G1146-55.
1994: Patricia Lemarchand; M Jones; C Danel; I Yamada; A Mastrangeli; Helen-Ann Brown Epstein
In vivo adenovirus-mediated gene transfer to lungs via pulmonary artery.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(6):2840-5.
1994: S L Brody; Helen-Ann Brown Epstein
Adenovirus-mediated in vivo gene transfer.
Annals of the New York Academy of Sciences 1994;716():90-101; discussion 101-3.
1994: Y Setoguchi; H Ari Jaffe; C Danel; Helen-Ann Brown Epstein
Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors.
The Journal of investigative dermatology 1994;102(4):415-21.
1994: Y Setoguchi; H Ari Jaffe; C S Chu; Helen-Ann Brown Epstein
Intraperitoneal in vivo gene therapy to deliver alpha 1-antitrypsin to the systemic circulation.
American journal of respiratory cell and molecular biology 1994;10(4):369-77.
1994: S L Brody; H Ari Jaffe; S K Han; RP Wersto; Helen-Ann Brown Epstein
Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors.
Human gene therapy 1994;5(4):437-47.
1994: M A Rosenfeld; C S Chu; P Seth; C Danel; T Banks; K Yoneyama; K Yoshimura; Helen-Ann Brown Epstein
Gene transfer to freshly isolated human respiratory epithelial cells in vitro using a replication-deficient adenovirus containing the human cystic fibrosis transmembrane conductance regulator cDNA.
Human gene therapy 1994;5(3):331-42.
1994: Prem Seth; M Rosenfeld; J Higginbotham; Helen-Ann Brown Epstein
Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA.
Journal of virology 1994;68(2):933-40.
1994: J H Yoo; S C Erzurum; J G Hay; Patricia Lemarchand; Helen-Ann Brown Epstein
Vulnerability of the human airway epithelium to hyperoxia. Constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress.
The Journal of clinical investigation 1994;93(1):297-302.
1993: R J Guzman; Patricia Lemarchand; Helen-Ann Brown Epstein; Stephen E Epstein; TOREN FINKEL
Efficient and selective adenovirus-mediated gene transfer into vascular neointima.
Circulation 1993;88(6):2838-48.
1993: R J Guzman; Patricia Lemarchand; Helen-Ann Brown Epstein; Stephen E Epstein; TOREN FINKEL
Efficient gene transfer into myocardium by direct injection of adenovirus vectors.
Circulation research 1993;73(6):1202-7.
1993: J H Roum; R Buhl; Noel G McElvaney; Z Borok; Helen-Ann Brown Epstein
Systemic deficiency of glutathione in cystic fibrosis.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(6):2419-24.
1993: William D Travis; Z Borok; J H Roum; J Zhang; IM Feuerstein; V J Ferrans; Helen-Ann Brown Epstein
Pulmonary Langerhans cell granulomatosis (histiocytosis X). A clinicopathologic study of 48 cases.
The American journal of surgical pathology 1993;17(10):971-86.
1993: M A Rosenfeld; G Ronald; Helen-Ann Brown Epstein
Gene therapy for pulmonary diseases.
Pathologie-biologie 1993;41(8):677-80.
1993: K J Holroyd; R Buhl; Z Borok; J H Roum; A D Bokser; G J Grimes; D Czerski; A M Cantin; Helen-Ann Brown Epstein
Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione aerosol treatment.
Thorax 1993;48(10):985-9.
1993: Noel G McElvaney; B Doujaiji; M J Moan; M R Burnham; M C Wu; Helen-Ann Brown Epstein
Pharmacokinetics of recombinant secretory leukoprotease inhibitor aerosolized to normals and individuals with cystic fibrosis.
The American review of respiratory disease 1993;148(4 Pt 1):1056-60.
1993: A Gillissen; J H Roum; Robert F Hoyt; Helen-Ann Brown Epstein
Aerosolization of superoxide dismutase. Augmentation of respiratory epithelial lining fluid antioxidant screen by aerosolization of recombinant human Cu++/Zn++ superoxide dismutase.
Chest 1993;104(3):811-5.
1993: S C Erzurum; C Danel; A Gillissen; C S Chu; B C Trapnell; Helen-Ann Brown Epstein
In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O2.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(3):1256-62.
1993: A Gillissen; P Birrer; Noel G McElvaney; R Buhl; Claus Vogelmeier; Robert F Hoyt; R C Hubbard; Helen-Ann Brown Epstein
Recombinant secretory leukoprotease inhibitor augments glutathione levels in lung epithelial lining fluid.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(2):825-32.
1993: Patricia Lemarchand; M Jones; I Yamada; Helen-Ann Brown Epstein
In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors.
Circulation research 1993;72(5):1132-8.
1993: S C Erzurum; Patricia Lemarchand; M A Rosenfeld; J H Yoo; Helen-Ann Brown Epstein
Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA.
Nucleic acids research 1993;21(7):1607-12.
1993: G Bajocchi; S H Feldman; Helen-Ann Brown Epstein; A Mastrangeli
Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors.
Nature genetics 1993;3(3):229-34.
1993: K Yoshimura; M A Rosenfeld; P Seth; Helen-Ann Brown Epstein
Adenovirus-mediated augmentation of cell transfection with unmodified plasmid vectors.
The Journal of biological chemistry 1993;268(4):2300-3.
1993: R Buhl; H Ari Jaffe; K J Holroyd; Z Borok; J H Roum; A Mastrangeli; F B Wells; M Kirby; C Saltini; Helen-Ann Brown Epstein
Activation of alveolar macrophages in asymptomatic HIV-infected individuals.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):1019-28.
1993: C S Chu; B C Trapnell; S Curristin; Garry R Cutting; Helen-Ann Brown Epstein
Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA.
Nature genetics 1993;3(2):151-6.
1993: K Yoshimura; C S Chu; Helen-Ann Brown Epstein
Alternative splicing of intron 23 of the human cystic fibrosis transmembrane conductance regulator gene resulting in a novel exon and transcript coding for a shortened intracytoplasmic C terminus.
The Journal of biological chemistry 1993;268(1):686-90.
1993: A Mastrangeli; C Danel; M A Rosenfeld; L Stratford-Perricaudet; M Perricaudet; A Pavirani; J P Lecocq; Helen-Ann Brown Epstein
Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer.
The Journal of clinical investigation 1993;91(1):225-34.
1992: H Nakamura; K Yoshimura; G Bajocchi; B C Trapnell; A Pavirani; Helen-Ann Brown Epstein
Tumor necrosis factor modulation of expression of the cystic fibrosis transmembrane conductance regulator gene.
FEBS letters 1992;314(3):366-70.
1992: Noel G McElvaney; H Nakamura; P Birrer; C A Hébert; W L Wong; M Alphonso; J B Baker; M A Catalano; Helen-Ann Brown Epstein
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor.
The Journal of clinical investigation 1992;90(4):1296-301.
1992: C S Chu; B C Trapnell; S M Curristin; Garry R Cutting; Helen-Ann Brown Epstein
Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestations of cystic fibrosis.
The Journal of clinical investigation 1992;90(3):785-90.
1992: J Bargon; B C Trapnell; K Yoshimura; W Dalemans; A Pavirani; J P Lecocq; Helen-Ann Brown Epstein
Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C.
The Journal of biological chemistry 1992;267(23):16056-60.
1992: Patricia Lemarchand; H Ari Jaffe; C Danel; M C Cid; H K Kleinman; L D Stratford-Perricaudet; M Perricaudet; A Pavirani; J P Lecocq; Helen-Ann Brown Epstein
Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6482-6.
1992: P Birrer; Noel G McElvaney; A Gillissen; Robert F Hoyt; D C Bloedow; R C Hubbard; Helen-Ann Brown Epstein
Intravenous recombinant secretory leukoprotease inhibitor augments antineutrophil elastase defense.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(1):317-23.
1992: K Yoshimura; M A Rosenfeld; H Nakamura; E M Scherer; A Pavirani; J P Lecocq; Helen-Ann Brown Epstein
Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer.
Nucleic acids research 1992;20(12):3233-40.
1992: Helen-Ann Brown Epstein
Gene therapy strategies for pulmonary disease.
The American journal of medicine 1992;92(6A):44S-52S.
1992: K Yoshimura; Helen-Ann Brown Epstein
Transcriptional and posttranscriptional modulation of human neutrophil elastase gene expression.
Blood 1992;79(10):2733-40.
1992: H Nakamura; K Yoshimura; Noel G McElvaney; Helen-Ann Brown Epstein
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
The Journal of clinical investigation 1992;89(5):1478-84.
1992: R M Du Bois; M Kirby; B Balbi; C Saltini; Helen-Ann Brown Epstein
T-lymphocytes that accumulate in the lung in sarcoidosis have evidence of recent stimulation of the T-cell antigen receptor.
The American review of respiratory disease 1992;145(5):1205-11.
1992: J Bargon; B C Trapnell; C S Chu; E R Rosenthal; K Yoshimura; William B Guggino; W Dalemans; A Pavirani; J P Lecocq; Helen-Ann Brown Epstein
Down-regulation of cystic fibrosis transmembrane conductance regulator gene expression by agents that modulate intracellular divalent cations.
Molecular and cellular biology 1992;12(4):1872-8.
1992: R C Hubbard; Noel G McElvaney; P Birrer; S Shak; W W Robinson; C Jolley; M Wu; M S Chernick; Helen-Ann Brown Epstein
A preliminary study of aerosolized recombinant human deoxyribonuclease I in the treatment of cystic fibrosis.
The New England journal of medicine 1992;326(12):812-5.
1991: W Dalemans; Pascal Barbry; G Champigny; S Jallat; K Dott; D Dreyer; Helen-Ann Brown Epstein; A Pavirani; J P Lecocq; M Lazdunski
Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation.
Nature 1991;354(6354):526-8.
1991: Z Borok; A Gillissen; R Buhl; Robert F Hoyt; R C Hubbard; T Ozaki; S I Rennard; Helen-Ann Brown Epstein
Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E.
The American review of respiratory disease 1991;144(5):1080-4.
1991: H Nakamura; K Yoshimura; H Ari Jaffe; Helen-Ann Brown Epstein
Interleukin-8 gene expression in human bronchial epithelial cells.
The Journal of biological chemistry 1991;266(29):19611-7.
1991: K Yoshimura; H Nakamura; B C Trapnell; C S Chu; W Dalemans; A Pavirani; J P Lecocq; Helen-Ann Brown Epstein
Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin.
Nucleic acids research 1991;19(19):5417-23.
1991: M Fukayama; T Kanno; S L Brody; M Kirby; Helen-Ann Brown Epstein
Respiratory tract gene transfer. Transplantation of genetically modified T-lymphocytes directly to the respiratory epithelial surface.
The Journal of biological chemistry 1991;266(27):18339-44.
1991: Mark L Brantly; J T Wittes; Claus Vogelmeier; R C Hubbard; G A Fells; Helen-Ann Brown Epstein
Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes.
Chest 1991;100(3):703-8.
1991: R C Hubbard; G Fells; J Gadek; S Pacholok; J Humes; Helen-Ann Brown Epstein
Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages.
The Journal of clinical investigation 1991;88(3):891-7.
1991: B C Trapnell; C S Chu; P K Paakko; T C Banks; K Yoshimura; Victor J Ferrans; M S Chernick; Helen-Ann Brown Epstein
Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6565-9.
1991: Z Borok; R Buhl; G J Grimes; A D Bokser; R C Hubbard; K J Holroyd; J H Roum; D B Czerski; A M Cantin; Helen-Ann Brown Epstein
Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis.
Lancet 1991;338(8761):215-6.
1991: H Ari Jaffe; R Buhl; A Mastrangeli; K J Holroyd; C Saltini; D Czerski; H S Jaffe; S Kramer; S Sherwin; Helen-Ann Brown Epstein
Organ specific cytokine therapy. Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon-gamma to the human lung.
The Journal of clinical investigation 1991;88(1):297-302.
1991: R M du Bois; J F Bernaudin; P Paakko; R Hubbard; H Takahashi; Victor J Ferrans; Helen-Ann Brown Epstein
Human neutrophils express the alpha 1-antitrypsin gene and produce alpha 1-antitrypsin.
Blood 1991;77(12):2724-30.
1991: H Okayama; Mark L Brantly; M Holmes; Helen-Ann Brown Epstein
Characterization of the molecular basis of the alpha 1-antitrypsin F allele.
American journal of human genetics 1991;48(6):1154-8.
1991: T Abe; N Kobayashi; K Yoshimura; B C Trapnell; H Kim; R C Hubbard; M T Brewer; R C Thompson; Helen-Ann Brown Epstein
Expression of the secretory leukoprotease inhibitor gene in epithelial cells.
The Journal of clinical investigation 1991;87(6):2207-15.
1991: K Yoshimura; H Nakamura; B C Trapnell; W Dalemans; A Pavirani; J P Lecocq; Helen-Ann Brown Epstein
The cystic fibrosis gene has a "housekeeping"-type promoter and is expressed at low levels in cells of epithelial origin.
The Journal of biological chemistry 1991;266(14):9140-4.
1991: F Ogushi; R C Hubbard; Claus Vogelmeier; G A Fells; Helen-Ann Brown Epstein
Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase.
The Journal of clinical investigation 1991;87(3):1060-5.
1991: N Tamura; David R Moller; B Balbi; Helen-Ann Brown Epstein
Preferential usage of the T-cell antigen receptor beta-chain constant region C beta 1 element by lung T-lymphocytes of patients with pulmonary sarcoidosis.
The American review of respiratory disease 1991;143(3):635-9.
1991: Noel G McElvaney; R C Hubbard; P Birrer; M S Chernick; D B Caplan; M M Frank; Helen-Ann Brown Epstein
Aerosol alpha 1-antitrypsin treatment for cystic fibrosis.
Lancet 1991;337(8738):392-4.
1991: Helen-Ann Brown Epstein
Alpha 1-antitrypsin deficiency: pathogenesis and treatment.
Hospital practice (Office ed.) 1991;26(2):81-4, 88-9, 93-4.
1991: Claus Vogelmeier; R C Hubbard; G A Fells; H P Schnebli; R C Thompson; H Fritz; Helen-Ann Brown Epstein
Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor.
The Journal of clinical investigation 1991;87(2):482-8.
1991: P Birrer; Noel G McElvaney; L M Chang-Stroman; Helen-Ann Brown Epstein
Alpha 1-antitrypsin deficiency and liver disease.
Journal of inherited metabolic disease 1991;14(4):512-25.
1990: Claus Vogelmeier; R Buhl; Robert F Hoyt; E Wilson; G A Fells; R C Hubbard; H P Schnebli; R C Thompson; Helen-Ann Brown Epstein
Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(5):1843-8.
1990: M D Holmes; Mark L Brantly; Helen-Ann Brown Epstein
Molecular analysis of the heterogeneity among the P-family of alpha-1-antitrypsin alleles.
The American review of respiratory disease 1990;142(5):1185-92.
1990: W N Rom; V K Vijayan; M J Cornelius; Vasanthapuram Kumaraswami; R Prabhakar; E A Ottesen; Helen-Ann Brown Epstein
Persistent lower respiratory tract inflammation associated with interstitial lung disease in patients with tropical pulmonary eosinophilia following conventional treatment with diethylcarbamazine.
The American review of respiratory disease 1990;142(5):1088-92.
1990: A M Cantin; G A Fells; R C Hubbard; Helen-Ann Brown Epstein
Antioxidant macromolecules in the epithelial lining fluid of the normal human lower respiratory tract.
The Journal of clinical investigation 1990;86(3):962-71.
1990: H Takahashi; Helen-Ann Brown Epstein
Alpha 1-antitrypsin Null(isola di procida): an alpha 1-antitrypsin deficiency allele caused by deletion of all alpha 1-antitrypsin coding exons.
American journal of human genetics 1990;47(3):403-13.
1990: M D Holmes; Mark L Brantly; G A Fells; Helen-Ann Brown Epstein
Alpha 1-antitrypsin Wbethesda: molecular basis of an unusual alpha 1-antitrypsin deficiency variant.
Biochemical and biophysical research communications 1990;170(3):1013-20.
1990: N Tamura; K J Holroyd; T Banks; M Kirby; H Okayama; Helen-Ann Brown Epstein
Diversity in junctional sequences associated with the common human V gamma 9 and V delta 2 gene segments in normal blood and lung compared with the limited diversity in a granulomatous disease.
The Journal of experimental medicine 1990;172(1):169-81.
1990: R Buhl; Claus Vogelmeier; M Critenden; R C Hubbard; Robert F Hoyt; E M Wilson; A M Cantin; Helen-Ann Brown Epstein
Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(11):4063-7.
1990: I Nagaoka; B C Trapnell; Helen-Ann Brown Epstein
Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.
The Journal of clinical investigation 1990;85(6):2023-7.
1990: Helen-Ann Brown Epstein
Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy.
The Journal of clinical investigation 1990;85(5):1343-52.
1990: B Balbi; David R Moller; M Kirby; K J Holroyd; Helen-Ann Brown Epstein
Increased numbers of T lymphocytes with gamma delta-positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis.
The Journal of clinical investigation 1990;85(5):1353-61.
1990: M D Holmes; Mark L Brantly; D T Curiel; S Weidinger; Helen-Ann Brown Epstein
Characterization of the normal alpha 1-antitrypsin allele Vmunich: a variant associated with a unique protein isoelectric focusing pattern.
American journal of human genetics 1990;46(4):810-6.
1990: C Saltini; M Kirby; B C Trapnell; N Tamura; Helen-Ann Brown Epstein
Biased accumulation of T lymphocytes with "memory"-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung.
The Journal of experimental medicine 1990;171(4):1123-40.
1990: R Buhl; H Ari Jaffe; K J Holroyd; F B Wells; A Mastrangeli; C Saltini; A M Cantin; Helen-Ann Brown Epstein
Glutathione deficiency and HIV.
Lancet 1990;335(8688):546.
1990: R C Hubbard; Helen-Ann Brown Epstein
Augmentation therapy of alpha 1-antitrypsin deficiency.
The European respiratory journal. Supplement 1990;9():44s-52s.
1990: I Nagaoka; B C Trapnell; Helen-Ann Brown Epstein
Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937.
The Journal of clinical investigation 1990;85(2):448-55.
1990: K J Holroyd; N Tamura; T Banks; M Kirby; H Okayama; Helen-Ann Brown Epstein
Limited diversity of gamma delta T-cell antigen receptor junctional region sequences in individuals with sarcoidosis compared to broad diversity in normal subjects.
Transactions of the Association of American Physicians 1990;103():102-11.
1990: R C Hubbard; Helen-Ann Brown Epstein
Strategies for aerosol therapy of alpha 1-antitrypsin deficiency by the aerosol route.
Lung 1990;168 Suppl():565-78.
1990: D T Curiel; Claus Vogelmeier; R C Hubbard; L E Stier; Helen-Ann Brown Epstein
Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele.
Molecular and cellular biology 1990;10(1):47-56.
1989: R Buhl; H Ari Jaffe; K J Holroyd; F B Wells; A Mastrangeli; C Saltini; A M Cantin; Helen-Ann Brown Epstein
Systemic glutathione deficiency in symptom-free HIV-seropositive individuals.
Lancet 1989;2(8675):1294-8.
1989: Thomas B Nutman; V K Vijayan; P Pinkston; Vasanthapuram Kumaraswami; C Steel; Helen-Ann Brown Epstein; E A Ottesen
Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lung.
The Journal of infectious diseases 1989;160(6):1042-50.
1989: D Curiel; V Laubach; Claus Vogelmeier; L Wurts; Helen-Ann Brown Epstein
Characterization of the sequence of the normal alpha-1-antitrypsin M3 allele and function of the M3 protein.
American journal of respiratory cell and molecular biology 1989;1(6):471-7.
1989: T Takemura; W N Rom; V J Ferrans; Helen-Ann Brown Epstein
Morphologic characterization of alveolar macrophages from subjects with occupational exposure to inorganic particles.
The American review of respiratory disease 1989;140(6):1674-85.
1989: M Holmes; D Curiel; Mark L Brantly; Helen-Ann Brown Epstein
Characterization of the intracellular mechanism causing the alpha-1-antitrypsin Nullgranite falls deficiency state.
The American review of respiratory disease 1989;140(6):1662-7.
1989: R C Hubbard; Noel G McElvaney; Stephanie Sellers; J T Healy; D B Czerski; Helen-Ann Brown Epstein
Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency.
The Journal of clinical investigation 1989;84(4):1349-54.
1989: T Abe; H Takahashi; M D Holmes; D T Curiel; Helen-Ann Brown Epstein
Ribonuclease A cleavage combined with the polymerase chain reaction for detection of the Z mutation of the alpha-1-antitrypsin gene.
American journal of respiratory cell and molecular biology 1989;1(4):329-34.
1989: H Okayama; M D Holmes; Mark L Brantly; Helen-Ann Brown Epstein
Characterization of the coding sequence of the normal M4 alpha 1-antitrypsin gene.
Biochemical and biophysical research communications 1989;162(3):1560-70.
1989: D T Curiel; M D Holmes; H Okayama; Mark L Brantly; Claus Vogelmeier; William D Travis; L E Stier; W H Perks; Helen-Ann Brown Epstein
Molecular basis of the liver and lung disease associated with the alpha 1-antitrypsin deficiency allele Mmalton.
The Journal of biological chemistry 1989;264(23):13938-45.
1989: H Okayama; D T Curiel; Mark L Brantly; M D Holmes; Helen-Ann Brown Epstein
Rapid, nonradioactive detection of mutations in the human genome by allele-specific amplification.
The Journal of laboratory and clinical medicine 1989;114(2):105-13.
1989: R C Hubbard; Mark L Brantly; Stephanie Sellers; M E Mitchell; Helen-Ann Brown Epstein
Anti-neutrophil-elastase defenses of the lower respiratory tract in alpha 1-antitrypsin deficiency directly augmented with an aerosol of alpha 1-antitrypsin.
Annals of internal medicine 1989;111(3):206-12.
1989: J R Spurzem; C Saltini; M Kirby; K Konishi; Helen-Ann Brown Epstein
Expression of HLA class II genes in alveolar macrophages of patients with sarcoidosis.
The American review of respiratory disease 1989;140(1):89-94.
1989: D T Curiel; A Chytil; M Courtney; Helen-Ann Brown Epstein
Serum alpha 1-antitrypsin deficiency associated with the common S-type (Glu264----Val) mutation results from intracellular degradation of alpha 1-antitrypsin prior to secretion.
The Journal of biological chemistry 1989;264(18):10477-86.
1989: C Saltini; K Winestock; M Kirby; P Pinkston; Helen-Ann Brown Epstein
Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T cells.
The New England journal of medicine 1989;320(17):1103-9.
1989: D Curiel; Mark L Brantly; E Curiel; L Stier; Helen-Ann Brown Epstein
Alpha 1-antitrypsin deficiency caused by the alpha 1-antitrypsin Nullmattawa gene. An insertion mutation rendering the alpha 1-antitrypsin gene incapable of producing alpha 1-antitrypsin.
The Journal of clinical investigation 1989;83(4):1144-52.
1989: P Fouret; R M du Bois; J F Bernaudin; H Takahashi; Victor J Ferrans; Helen-Ann Brown Epstein
Expression of the neutrophil elastase gene during human bone marrow cell differentiation.
The Journal of experimental medicine 1989;169(3):833-45.
1989: A M Cantin; R C Hubbard; Helen-Ann Brown Epstein
Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis.
The American review of respiratory disease 1989;139(2):370-2.
1989: R C Hubbard; M A Casolaro; M Mitchell; Stephanie Sellers; F Arabia; M A Matthay; Helen-Ann Brown Epstein
Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):680-4.
1989: Helen-Ann Brown Epstein; Mark L Brantly; R C Hubbard; D T Curiel; David States; M D Holmes
The alpha 1-antitrypsin gene and its mutations. Clinical consequences and strategies for therapy.
Chest 1989;95(1):196-208.
1988: Mark L Brantly; M Courtney; Helen-Ann Brown Epstein
Repair of the secretion defect in the Z form of alpha 1-antitrypsin by addition of a second mutation.
Science (New York, N.Y.) 1988;242(4886):1700-2.
1988: Y Martinet; P Pinkston; C Saltini; J Spurzem; J Müller-Quernheim; Helen-Ann Brown Epstein
Evaluation of the in vitro and in vivo effects of cyclosporine on the lung T-lymphocyte alveolitis of active pulmonary sarcoidosis.
The American review of respiratory disease 1988;138(5):1242-8.
1988: H Takahashi; T Nukiwa; K Satoh; F Ogushi; Mark L Brantly; G Fells; L Stier; M Courtney; Helen-Ann Brown Epstein
Characterization of the gene and protein of the alpha 1-antitrypsin "deficiency" allele Mprocida.
The Journal of biological chemistry 1988;263(30):15528-34.
1988: H Takahashi; T Nukiwa; K Yoshimura; C D Quick; David States; M D Holmes; J Whang-Peng; T Knutsen; Helen-Ann Brown Epstein
Structure of the human neutrophil elastase gene.
The Journal of biological chemistry 1988;263(29):14739-47.
1988: David R Moller; K Konishi; M Kirby; B Balbi; Helen-Ann Brown Epstein
Bias toward use of a specific T cell receptor beta-chain variable region in a subgroup of individuals with sarcoidosis.
The Journal of clinical investigation 1988;82(4):1183-91.
1988: R C Hubbard; Stephanie Sellers; D Czerski; L Stephens; Helen-Ann Brown Epstein
Biochemical efficacy and safety of monthly augmentation therapy for alpha 1-antitrypsin deficiency.
JAMA : the journal of the American Medical Association 1988;260(9):1259-64.
1988: Y Martinet; K Yamauchi; Helen-Ann Brown Epstein
Differential expression of the tumor necrosis factor/cachectin gene by blood and lung mononuclear phagocytes.
The American review of respiratory disease 1988;138(3):659-65.
1988: K Konishi; David R Moller; C Saltini; M Kirby; Helen-Ann Brown Epstein
Spontaneous expression of the interleukin 2 receptor gene and presence of functional interleukin 2 receptors on T lymphocytes in the blood of individuals with active pulmonary sarcoidosis.
The Journal of clinical investigation 1988;82(3):775-81.
1988: T Nukiwa; Mark L Brantly; F Ogushi; G A Fells; Helen-Ann Brown Epstein
Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele.
American journal of human genetics 1988;43(3):322-30.
1988: Mark L Brantly; L D Paul; B H Miller; R T Falk; M Wu; Helen-Ann Brown Epstein
Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms.
The American review of respiratory disease 1988;138(2):327-36.
1988: R C Hubbard; Helen-Ann Brown Epstein
Alpha-1-antitrypsin augmentation therapy for alpha-1-antitrypsin deficiency.
The American journal of medicine 1988;84(6A):52-62.
1988: Mark L Brantly; T Nukiwa; Helen-Ann Brown Epstein
Molecular basis of alpha-1-antitrypsin deficiency.
The American journal of medicine 1988;84(6A):13-31.
1988: J F Bernaudin; K Yamauchi; M D Wewers; M J Tocci; V J Ferrans; Helen-Ann Brown Epstein
Demonstration by in situ hybridization of dissimilar IL-1 beta gene expression in human alveolar macrophages and blood monocytes in response to lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(11):3822-9.
1988: K Yamauchi; Y Martinet; P Basset; G A Fells; Helen-Ann Brown Epstein
High levels of transforming growth factor-beta are present in the epithelial lining fluid of the normal human lower respiratory tract.
The American review of respiratory disease 1988;137(6):1360-3.
1988: C Saltini; J R Spurzem; M R Kirby; Helen-Ann Brown Epstein
Sarcoidosis is not associated with a generalized defect in T cell suppressor function.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(6):1854-60.
1988: J R Spurzem; C Saltini; Helen-Ann Brown Epstein
Functional significance of anti-T-lymphocyte antibodies in sarcoidosis.
The American review of respiratory disease 1988;137(3):600-5.
1988: H Takahashi; T Nukiwa; P Basset; Helen-Ann Brown Epstein
Myelomonocytic cell lineage expression of the neutrophil elastase gene.
The Journal of biological chemistry 1988;263(5):2543-7.
1988: M A Casolaro; J F Bernaudin; C Saltini; V J Ferrans; Helen-Ann Brown Epstein
Accumulation of Langerhans' cells on the epithelial surface of the lower respiratory tract in normal subjects in association with cigarette smoking.
The American review of respiratory disease 1988;137(2):406-11.
1988: F Ogushi; R C Hubbard; G A Fells; M A Casolaro; D T Curiel; Mark L Brantly; Helen-Ann Brown Epstein
Evaluation of the S-type of alpha-1-antitrypsin as an in vivo and in vitro inhibitor of neutrophil elastase.
The American review of respiratory disease 1988;137(2):364-70.
1988: S I Rennard; P B Bitterman; T Ozaki; W N Rom; Helen-Ann Brown Epstein
Colchicine suppresses the release of fibroblast growth factors from alveolar macrophages in vitro. The basis of a possible therapeutic approach ot the fibrotic disorders.
The American review of respiratory disease 1988;137(1):181-5.
1988: A J Hance; C Saltini; Helen-Ann Brown Epstein
Does de novo immunoglobulin synthesis occur on the epithelial surface of the human lower respiratory tract?
The American review of respiratory disease 1988;137(1):17-24.
1988: K Satoh; T Nukiwa; Mark L Brantly; R I Garver; M Hofker; M Courtney; Helen-Ann Brown Epstein
Emphysema associated with complete absence of alpha 1- antitrypsin in serum and the homozygous inheritance [corrected] of a stop codon in an alpha 1-antitrypsin-coding exon.
American journal of human genetics 1988;42(1):77-83.
1987: K Yamauchi; Y Martinet; Helen-Ann Brown Epstein
Modulation of fibronectin gene expression in human mononuclear phagocytes.
The Journal of clinical investigation 1987;80(6):1720-7.
1987: W N Rom; P B Bitterman; S I Rennard; A Cantin; Helen-Ann Brown Epstein
Characterization of the lower respiratory tract inflammation of nonsmoking individuals with interstitial lung disease associated with chronic inhalation of inorganic dusts.
The American review of respiratory disease 1987;136(6):1429-34.
1987: F Ogushi; G A Fells; R C Hubbard; S D Straus; Helen-Ann Brown Epstein
Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.
The Journal of clinical investigation 1987;80(5):1366-74.
1987: R C Hubbard; F Ogushi; G A Fells; A M Cantin; S Jallat; M Courtney; Helen-Ann Brown Epstein
Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.
The Journal of clinical investigation 1987;80(5):1289-95.
1987: T Nukiwa; Mark L Brantly; F Ogushi; G Fells; K Satoh; L Stier; M Courtney; Helen-Ann Brown Epstein
Characterization of the M1(Ala213) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype.
Biochemistry 1987;26(17):5259-67.
1987: R I Garver; A Chytil; M Courtney; Helen-Ann Brown Epstein
Clonal gene therapy: transplanted mouse fibroblast clones express human alpha 1-antitrypsin gene in vivo.
Science (New York, N.Y.) 1987;237(4816):762-4.
1987: P Pinkston; C Saltini; J Müller-Quernheim; Helen-Ann Brown Epstein
Corticosteroid therapy suppresses spontaneous interleukin 2 release and spontaneous proliferation of lung T lymphocytes of patients with active pulmonary sarcoidosis.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(3):755-60.
1987: J R Spurzem; C Saltini; W Rom; R J Winchester; Helen-Ann Brown Epstein
Mechanisms of macrophage accumulation in the lungs of asbestos-exposed subjects.
The American review of respiratory disease 1987;136(2):276-80.
1987: A M Cantin; S L North; R C Hubbard; Helen-Ann Brown Epstein
Normal alveolar epithelial lining fluid contains high levels of glutathione.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(1):152-7.
1987: A M Cantin; S L North; G A Fells; R C Hubbard; Helen-Ann Brown Epstein
Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.
The Journal of clinical investigation 1987;79(6):1665-73.
1987: M D Wewers; M A Casolaro; Stephanie Sellers; S C Swayze; K M McPhaul; J T Wittes; Helen-Ann Brown Epstein
Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema.
The New England journal of medicine 1987;316(17):1055-62.
1987: M D Wewers; M A Casolaro; Helen-Ann Brown Epstein
Comparison of alpha-1-antitrypsin levels and antineutrophil elastase capacity of blood and lung in a patient with the alpha-1-antitrypsin phenotype null-null before and during alpha-1-antitrypsin augmentation therapy.
The American review of respiratory disease 1987;135(3):539-43.
1987: M D Wewers; Mark L Brantly; M A Casolaro; Helen-Ann Brown Epstein
Evaluation of tamoxifen as a therapy to augment alpha-1-antitrypsin concentrations in Z homozygous alpha-1-antitrypsin-deficient subjects.
The American review of respiratory disease 1987;135(2):401-2.
1987: R I Garver; A Chytil; S Karlsson; G A Fells; Mark L Brantly; M Courtney; Philip W Kantoff; A W Nienhuis; W F Anderson; Helen-Ann Brown Epstein
Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(4):1050-4.
1987: R I Garver; A Chytil; M Courtney; Helen-Ann Brown Epstein
Clonal gene therapy: in vivo expression of a transplanted monoclonal population of murine fibroblasts containing a retrovirus inserted human alpha 1-antitrypsin gene.
Transactions of the Association of American Physicians 1987;100():10-20.
1986: T Nukiwa; K Satoh; Mark L Brantly; F Ogushi; G A Fells; M Courtney; Helen-Ann Brown Epstein
Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene.
The Journal of biological chemistry 1986;261(34):15989-94.
1986: L H Tessier; S Jallat; M Sauvageot; Helen-Ann Brown Epstein; M Courtney
RNA structural elements for expression in Escherichia coli. Alpha 1-antitrypsin synthesis using translation control elements based on the cII ribosome-binding site of phage lambda.
FEBS letters 1986;208(2):183-8.
1986: S Jallat; D Carvallo; L H Tessier; D Roecklin; C Roitsch; F Ogushi; Helen-Ann Brown Epstein; M Courtney
Altered specificities of genetically engineered alpha 1 antitrypsin variants.
Protein engineering 1986;1(1):29-35.
1986: S Jallat; L H Tessier; A Benavente; Helen-Ann Brown Epstein; M Courtney
Antiprotease targeting: altered specificity of alpha 1-antitrypsin by amino acid replacement at the reactive centre.
Revue française de transfusion et immuno-hématologie 1986;29(4):287-98.
1986: C Saltini; J R Spurzem; J J Lee; P Pinkston; Helen-Ann Brown Epstein
Spontaneous release of interleukin 2 by lung T lymphocytes in active pulmonary sarcoidosis is primarily from the Leu3+DR+ T cell subset.
The Journal of clinical investigation 1986;77(6):1962-70.
1986: R I Garver; J F Mornex; T Nukiwa; Mark L Brantly; M Courtney; J P LeCocq; Helen-Ann Brown Epstein
Alpha 1-antitrypsin deficiency and emphysema caused by homozygous inheritance of non-expressing alpha 1-antitrypsin genes.
The New England journal of medicine 1986;314(12):762-6.
1986: S I Rennard; G Basset; Denise Lecossier; K M O'Donnell; P Pinkston; P G Martin; Helen-Ann Brown Epstein
Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution.
Journal of applied physiology (Bethesda, Md. : 1985) 1986;60(2):532-8.
1986: T Nukiwa; M Brantly; R Garver; L Paul; M Courtney; J P LeCocq; Helen-Ann Brown Epstein
Evaluation of "at risk" alpha 1-antitrypsin genotype SZ with synthetic oligonucleotide gene probes.
The Journal of clinical investigation 1986;77(2):528-37.
1985: S D Straus; G A Fells; M D Wewers; M Courtney; L H Tessier; P Tolstoshev; J P Lecocq; Helen-Ann Brown Epstein
Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency.
Biochemical and biophysical research communications 1985;130(3):1177-84.
1985: M Courtney; S Jallat; L H Tessier; A Benavente; Helen-Ann Brown Epstein; J P Lecocq
Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis.
Nature 1985;313(5998):149-51.
1981: C Schoenberger; Gary W Hunninghake; J Gadek; Helen-Ann Brown Epstein
Inflammation and asbestosis: characterization and maintenance of alveolitis following acute asbestos exposure.
Chest 1981;80(1 Suppl):70-1.
1981: P Bitterman; S Rennard; C Schoenberger; Helen-Ann Brown Epstein
Asbestos stimulates alveolar macrophages to release a factor causing human lung fibroblasts to replicate.
Chest 1981;80(1 Suppl):38-9.
1981: J Gadek; Gary W Hunninghake; C Schoenberger; G Fells; Helen-Ann Brown Epstein
Pulmonary asbestosis and idiopathic pulmonary fibrosis: pathogenetic parallels.
Chest 1981;80(1 Suppl):63-4.
1980: Gary W Hunninghake; J Gadek; Helen-Ann Brown Epstein
Mechanism by which cigarette smoke attracts polymorphonuclear leukocytes to lung.
Chest 1980;77(2 Suppl):273.
1980: J Gadek; J Fulmer; M Frank; T Petty; Helen-Ann Brown Epstein
Danazol-induced elevation of serum alpha 1-antitrypsin in individuals with severe deficiency of this antiprotease.
Chest 1980;77(2 Suppl):279.