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Jaap Middeldorp

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Cindy Chang; Chien-Jen Chen; Jen-Yang Chen; Wan-Lun Hsu; Hedy Juwana; Mei-Ying Liu; Pei-Jen Lou; Jaap Middeldorp; Ruth M Pfeiffer; Cheng-Ping Wang; Kelly J Yu; Allan Hildesheim
Characterization of ELISA detection of broad-spectrum anti-Epstein-Barr virus antibodies associated with nasopharyngeal carcinoma.
Melina Arnold; I Bing Tan; Renske Fles; Henrike E Karim-Kos; Jaap Middeldorp; Otto Visser; Maarten A Wildeman; Jan Willem Coebergh
Lower mortality from nasopharyngeal cancer in The Netherlands since 1970 with differential incidence trends in histopathology.
Danijela Koppers-Lalic; Jaap Middeldorp; Marye M Hogenboom; D Michiel Pegtel
Virus-modified exosomes for targeted RNA delivery; a new approach in nanomedicine.

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2013: Cindy Chang; Chien-Jen Chen; Jen-Yang Chen; Wan-Lun Hsu; Hedy Juwana; Mei-Ying Liu; Pei-Jen Lou; Jaap Middeldorp; Ruth M Pfeiffer; Cheng-Ping Wang; Kelly J Yu; Allan Hildesheim
Characterization of ELISA detection of broad-spectrum anti-Epstein-Barr virus antibodies associated with nasopharyngeal carcinoma.
Journal of medical virology 2013;85(3):524-9.
2013: Melina Arnold; I Bing Tan; Renske Fles; Henrike E Karim-Kos; Jaap Middeldorp; Otto Visser; Maarten A Wildeman; Jan Willem Coebergh
Lower mortality from nasopharyngeal cancer in The Netherlands since 1970 with differential incidence trends in histopathology.
Oral oncology 2013;49(3):237-43.
2013: Danijela Koppers-Lalic; Jaap Middeldorp; Marye M Hogenboom; D Michiel Pegtel
Virus-modified exosomes for targeted RNA delivery; a new approach in nanomedicine.
Advanced drug delivery reviews 2013;65(3):348-56.
2012: Chi Man Tsang; Yim Ling Yip; Musheng Zeng; Honglin Chen; Annie Lai-Man Cheung; Wen Deng; Pok Man Hau; Victoria Ming Yi Lau; Kwok Wai Lo; Vivian Wai Yan Lui; Maria Li Lung; Jaap Middeldorp; Kenzo Takada; Ka Fai To; Sai Wah Tsao
Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):E3473-82.
2012: Eveline K Hoebe; Tessa Y S Le Large; Jaap Middeldorp; Dinja Oosterhoff; Nicolas Tarbouriech; Tanja D de Gruijl; Astrid E Greijer
Epstein-Barr virus-encoded BARF1 protein is a decoy receptor for macrophage colony stimulating factor and interferes with macrophage differentiation and activation.
Viral immunology 2012;25(6):461-70.
2012: Sean I Tracy; Kristina Kakalacheva; Jan D Lünemann; Katherine Luzuriaga; Jaap Middeldorp; David A Thorley-Lawson
Persistence of Epstein-Barr virus in self-reactive memory B cells.
Journal of virology 2012;86(22):12330-40.
2012: K F Hui; Jaap Middeldorp; C M Tsang; George S W Tsao; Dona N Ho; Kwok Shing Chiang
Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma.
International journal of cancer. Journal international du cancer 2012;131(8):1930-40.
2012: Eveline K Hoebe; E S Hopmans; S C Kenney; Jaap Middeldorp; A R Robinson; C Wille; Astrid E Greijer
Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation.
Journal of virology 2012;86(20):11322-32.
2012: Maarten A Wildeman; Jan Paul de Boer; Alwin D R Huitema; Hedy Juwana; Jaap Middeldorp; Zlata Novalic; I Bing Tan; Sandra A W M Verkuijlen; Astrid E Greijer
Cytolytic virus activation therapy for Epstein-Barr virus-driven tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(18):5061-70.
2012: Susanna Hilda Hutajulu; Baning Rahayu Jati; Nawi Ng; Jajah Fachiroh; Bambang Hariwiyanto; Sofia M Haryana; Camelia Herdini; Jaap Middeldorp
Seroreactivity against Epstein-Barr virus (EBV) among first-degree relatives of sporadic EBV-associated nasopharyngeal carcinoma in Indonesia.
Journal of medical virology 2012;84(5):768-76.
2012: Robert E White; Csaba Bödör; Mark Bower; Fathima Z Cader; Rita Coutinho; Maher K Gandhi; John Gribben; Hazem A Ibrahim; Sonja Meixlsperger; Jaap Middeldorp; Christian Münz; Paul Murray; Kikkeri N Naresh; Jamie P Nourse; Laurie Pinaud; Patrick C Rämer; Cliona Rooney; Barbara Savoldo; Martin J Allday
EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.
The Journal of clinical investigation 2012;122(4):1487-502.
2012: Marlinda Adham; Soehartati Gondhowiardjo; Bambang Hermani; Antonius N Kurniawan; Arina Ika Muhtadi; Averdi Roezin; I Bing Tan; Jaap Middeldorp
Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation.
Chinese journal of cancer 2012;31(4):185-96.
2012: Erwan Piriou; Robert Ploutz-Snyder; Peter O Sumba; Amolo S Asito; Nancy C Fiore; Jaap Middeldorp; Ann M Moormann; Rosemary Rochford
Early age at time of primary Epstein-Barr virus infection results in poorly controlled viral infection in infants from Western Kenya: clues to the etiology of endemic Burkitt lymphoma.
The Journal of infectious diseases 2012;205(6):906-13.
2012: J S Tzartos; M Cruz-Sadaba; A Meager; G Khan; Jaap Middeldorp; G Giovannoni; E Sefia; A Vossenkamper; P J Farrell; A Elia; S Lonardi; M Clemens; U-C Meier
Association of innate immune activation with latent Epstein-Barr virus in active MS lesions.
Neurology 2012;78(1):15-23.
2012: Astrid E Greijer; B G Hepkema; H Juwana; Servi J C Stevens; L F Verdonck; Sandra A W M Verkuijlen; Erik A M Verschuuren; R A Brooimans; J J Cornelissen; S C Fleig; Jaap Middeldorp
Variable EBV DNA load distributions and heterogeneous EBV mRNA expression patterns in the circulation of solid organ versus stem cell transplant recipients.
Clinical & developmental immunology 2012;2012():543085.
2012: Jackson Orem; Sven Sandin; Henry Wabinga; Fred Wabwire-Mangen; Caroline E Weibull; Edward Mbidde; Chris Jlm Meijer; Jaap Middeldorp; Michael Odida; ELISABETE WEIDERPASS
Agreement between diagnoses of childhood lymphoma assigned in Uganda and by an international reference laboratory.
Clinical epidemiology 2012;4():339-47.
2012: Zhe Zhang; Ingemar Ernberg; Sofia M Haryana; Guangwu Huang; Susanna Hilda Hutajulu; Jaap Middeldorp; Imran Nawaz; Do Nguyen Van; Di Sun; Li-Fu Hu
Development of a non-invasive method, multiplex methylation specific PCR (MMSP), for early diagnosis of nasopharyngeal carcinoma.
PloS one 2012;7(11):e45908.
2012: Frederik J Verweij; Jaap Middeldorp; D Michiel Pegtel
Intracellular signaling controlled by the endosomal-exosomal pathway.
Communicative & integrative biology 2012;5(1):88-93.
2012: Maarten A Wildeman; Andrew D Vincent; Marlinda Adham; Faiziah Fardizza; Renske Fles; Geerten Gerritsen; Ilse Luirink; Ika D Mayangsari; Jaap Middeldorp; Zanil Musa; Mara Sandberg; Ronny Suwanto; I Bing Tan
Short-term effect of different teaching methods on nasopharyngeal carcinoma for general practitioners in Jakarta, Indonesia.
PloS one 2012;7(3):e32756.
2012: Nirojini Sivachandran; Fei-Fei Liu; Lawrence S Young; Jaap Middeldorp; Christopher W Dawson; Lori Frappier
Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma.
Journal of virology 2012;86(1):60-8.
2011: D Michiel Pegtel; Martijn D B van de Garde; Jaap Middeldorp
Viral miRNAs exploiting the endosomal-exosomal pathway for intercellular cross-talk and immune evasion.
Biochimica et biophysica acta 2011;1809(11-12):715-21.
2011: Hans Lassmann; Jaap Middeldorp; Gerald Niedobitek; Francesca Aloisi
Epstein-Barr virus in the multiple sclerosis brain: a controversial issue--report on a focused workshop held in the Centre for Brain Research of the Medical University of Vienna, Austria.
Brain : a journal of neurology 2011;134(Pt 9):2772-86.
2011: Jin Qiu; Michael Shapiro; Katherine Cosmopoulos; Erik Hopmans; Jaap Middeldorp; Paul Murray; Michiel Pegtel; David A Thorley-Lawson
A novel persistence associated EBV miRNA expression profile is disrupted in neoplasia.
PLoS pathogens 2011;7(8):e1002193.
2011: Frederik J Verweij; Monique van Eijndhoven; Erik S Hopmans; Tineke Vendrig; Tom Wurdinger; Ellen Cahir-McFarland; Elliott Kieff; Dirk Geerts; Rik van der Kant; Jacques Neefjes; Jaap Middeldorp; D Michiel Pegtel
LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation.
The EMBO journal 2011;30(11):2115-29.
2011: Dewi K Paramita; Christien Fatmawati; Hedy Juwana; Frank G van Schaijk; Jajah Fachiroh; Sofia M Haryana; Jaap Middeldorp
Humoral immune responses to Epstein-Barr virus encoded tumor associated proteins and their putative extracellular domains in nasopharyngeal carcinoma patients and regional controls.
Journal of medical virology 2011;83(4):665-78.
2011: Jie Lu; Masanao Murakami; Verma Subhash; Qiliang Cai; Sabyasachi Haldar; Rajeev Kaul; Mariusz A Wasik; Jaap Middeldorp; Erle S Robertson
Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin.
Virology 2011;410(1):64-75.
2011: Eveline K Hoebe; S H Hutajulu; J van Beek; Servi J C Stevens; Dewi K Paramita; Astrid E Greijer; Jaap Middeldorp
Purified hexameric Epstein-Barr virus-encoded BARF1 protein for measuring anti-BARF1 antibody responses in nasopharyngeal carcinoma patients.
Clinical and vaccine immunology : CVI 2011;18(2):298-304.
2011: Delphine Casabonne; Oscar Reina; Yolanda Benavente; Nikolaus Becker; Marc Maynadié; Lenka Foretová; Pierluigi Cocco; Anna González-Neira; Alexandra Nieters; Paolo Boffetta; Jaap Middeldorp; Silvia de Sanjose
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Haematologica 2011;96(2):323-7.
2011: Maarten A Wildeman; Jeroen Zandbergen; Emile van der Donk; Andrew Vincent; Otilia Dalesio; Renske Fles; Camelia Herdini; Jaap Middeldorp; I Bing Tan
Can an online clinical data management service help in improving data collection and data quality in a developing country setting?
Trials 2011;12():190.
2011: Susanna H Hutajulu; Sagung R Indrasari; Luh P L Indrawati; Sylvia Duin; Astrid E Greijer; Ahmad Harijadi; Sofia M Haryana; Renske D M Steenbergen; Jaap Middeldorp
Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population.
Molecular cancer 2011;10():48.
2010: Barbara Cameron; Louis Flamand; Hedy Juwana; Jaap Middeldorp; Zin Naing; William D Rawlinson; Dharam Ablashi; Andrew Lloyd
Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.
Journal of medical virology 2010;82(10):1684-8.
2010: Jajah Fachiroh; Servi J C Stevens; Sofia M Haryana; Jaap Middeldorp
Combination of Epstein-Barr virus scaffold (BdRF1/VCA-p40) and small capsid protein (BFRF3/VCA-p18) into a single molecule for improved serodiagnosis of acute and malignant EBV-driven disease.
Journal of virological methods 2010;169(1):79-86.
2010: Chi Man Tsang; Guitao Zhang; Eri Seto; Kenzo Takada; Wen Deng; Yim Ling Yip; Cornelia Man; Pok Man Hau; Honglin Chen; Ya Cao; Kwok Wai Lo; Jaap Middeldorp; Annie Lai Man Cheung; Sai Wah Tsao
Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: regulation of infection and phenotypic characterization.
International journal of cancer. Journal international du cancer 2010;127(7):1570-83.
2010: Anoek Zomer; Tineke Vendrig; Erik S Hopmans; Monique van Eijndhoven; Jaap Middeldorp; D Michiel Pegtel
Exosomes: Fit to deliver small RNA.
Communicative & integrative biology 2010;3(5):447-50.
2010: Naghmeh Jafari; Gijsbert P van Nierop; Georges M G M Verjans; Albert D M E Osterhaus; Jaap Middeldorp; Rogier Q Hintzen
No evidence for intrathecal IgG synthesis to Epstein Barr virus nuclear antigen-1 in multiple sclerosis.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2010;49(1):26-31.
2010: Laura A N Peferoen; Floris Lamers; Lenthe N R Lodder; Wouter Gerritsen; Inge Huitinga; Jeroen Melief; Gavin Giovannoni; Ute Meier; Rogier Q Hintzen; Georges M G M Verjans; Gijsbert P van Nierop; Wim Vos; Regina M B Peferoen-Baert; Jaap Middeldorp; Paul Van Der Valk; Sandra Amor
Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis.
Brain : a journal of neurology 2010;133(Pt 5):e137.
2010: D Michiel Pegtel; Katherine Cosmopoulos; David A Thorley-Lawson; Monique van Eijndhoven; Erik S Hopmans; Jelle L Lindenberg; Tanja D de Gruijl; Thomas Würdinger; Jaap Middeldorp
Functional delivery of viral miRNAs via exosomes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(14):6328-33.
2010: Colleen Pelser; Jaap Middeldorp; Sam M Mbulaiteye; Carmela Lauria; Angelo Messina; Enza Viviano; n romano; Francesco Vitale; James J Goedert
Risk of classical Kaposi sarcoma by plasma levels of Epstein-Barr virus antibodies, sCD26, sCD23 and sCD30.
Infectious agents and cancer 2010;5():18.
2010: Susanna H Hutajulu; Eveline K Hoebe; Sandra A W M Verkuijlen; Jajah Fachiroh; Bambang Hariwijanto; Sofia M Haryana; Servi J C Stevens; Astrid E Greijer; Jaap Middeldorp
Conserved mutation of Epstein-Barr virus-encoded BamHI-A Rightward Frame-1 (BARF1) gene in Indonesian nasopharyngeal carcinoma.
Infectious agents and cancer 2010;5():16.
2010: Amolo S Asito; Erwan Piriou; Peter Sumba Odada; Nancy Fiore; Jaap Middeldorp; Carole A Long; Sheetij Dutta; David Lanar; Walter G Jura; Collins Ouma; Juliana A Otieno; Ann M Moormann; Rosemary Rochford
Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study.
Infectious agents and cancer 2010;5():13.
2009: Alexander A Benders; Weihua Tang; Jaap Middeldorp; Astrid E Greijer; Leigh B Thorne; William K Funkhouser; W Kimryn Rathmell; Margaret L Gulley
Epstein-Barr virus latent membrane protein 1 is not associated with vessel density nor with hypoxia inducible factor 1 alpha expression in nasopharyngeal carcinoma tissue.
Head and neck pathology 2009;3(4):276-82.
2009: Lesley Rees; E Jane Tizard; Andrew J Morgan; willoughby Cubitt; Susan Finerty; Titilade A Oyewole-Eletu; Karen Owen; Collin Royed; Servi J Stevens; Rukshana C Shroff; Manjit K Tanday; A Douglas Wilson; Jaap Middeldorp; Peter L Amlot; Neil M Steven
A phase I trial of epstein-barr virus gp350 vaccine for children with chronic kidney disease awaiting transplantation.
Transplantation 2009;88(8):1025-9.
2009: Kostas Paschos; Paul Smith; Emma Anderton; Jaap Middeldorp; Robert E White; Martin J Allday
Epstein-barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim.
PLoS pathogens 2009;5(6):e1000492.
2009: Nathan P Croft; Claire Shannon-Lowe; Andrew I Bell; Daniëlle Horst; Elisabeth Kremmer; Maaike E Ressing; Emmanuel J H J Wiertz; Jaap Middeldorp; Martin Rowe; Alan B Rickinson; Andrew D Hislop
Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle.
PLoS pathogens 2009;5(6):e1000490.
2009: Erwan Piriou; Rhonda Kimmel; Kiprotich Chelimo; Jaap Middeldorp; Peter Sumba Odada; Robert Ploutz-Snyder; Ann M Moormann; Rosemary Rochford
Serological evidence for long-term Epstein-Barr virus reactivation in children living in a holoendemic malaria region of Kenya.
Journal of medical virology 2009;81(6):1088-93.
2009: Dewi K Paramita; Jajah Fachiroh; Sofia M Haryana; Jaap Middeldorp
Two-step Epstein-Barr virus immunoglobulin A enzyme-linked immunosorbent assay system for serological screening and confirmation of nasopharyngeal carcinoma.
Clinical and vaccine immunology : CVI 2009;16(5):706-11.
2009: Katherine Cosmopoulos; Michiel Pegtel; Jared Hawkins; Howell Moffett; Carl D Novina; Jaap Middeldorp; David A Thorley-Lawson
Comprehensive profiling of Epstein-Barr virus microRNAs in nasopharyngeal carcinoma.
Journal of virology 2009;83(5):2357-67.
2008: Jaap Middeldorp; D M Pegtel
Multiple roles of LMP1 in Epstein-Barr virus induced immune escape.
Seminars in cancer biology 2008;18(6):388-96.
2008: Dewi K Paramita; Jajah Fachiroh; Sofia M Haryana; Jaap Middeldorp
Evaluation of commercial EBV RecombLine assay for diagnosis of nasopharyngeal carcinoma.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2008;42(4):343-52.
2008: Jajah Fachiroh; P R Prasetyanti; Dewi K Paramita; A T Prasetyawati; D W Anggrahini; Sofia M Haryana; Jaap Middeldorp
Dried-blood sampling for epstein-barr virus immunoglobulin G (IgG) and IgA serology in nasopharyngeal carcinoma screening.
Journal of clinical microbiology 2008;46(4):1374-80.
2008: Jianmin Zuo; Wendy Thomas; Daphne van Leeuwen; Jaap Middeldorp; Emmanuel J H J Wiertz; Maaike E Ressing; Martin Rowe
The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function.
Journal of virology 2008;82(5):2385-93.
2008: Eri Seto; Tadamasa Ooka; Jaap Middeldorp; Kenzo Takada
Reconstitution of nasopharyngeal carcinoma-type EBV infection induces tumorigenicity.
Cancer research 2008;68(4):1030-6.
2008: Marielle J Wondergem; Servi J C Stevens; Jeroen J W M Janssen; Joost Oudejans; Gert Ossenkoppele; Jaap Middeldorp; Sonja Zweegman
Monitoring of EBV reactivation is justified in patients with aplastic anemia treated with rabbit ATG as a second course of immunosuppression.
Blood 2008;111(3):1739; author reply 1739-40.
2007: Dewi K Paramita; Jajah Fachiroh; Wayan T Artama; Eric van Benthem; Sofia M Haryana; Jaap Middeldorp
Native early antigen of Epstein-Barr virus, a promising antigen for diagnosis of nasopharyngeal carcinoma.
Journal of medical virology 2007;79(11):1710-21.
2007: Servi J C Stevens; Paul H M Smits; Sandra A W M Verkuijlen; Davy A P Rockx; Eric C M van Gorp; Jan W Mulder; Jaap Middeldorp
Aberrant Epstein-Barr virus persistence in HIV carriers is characterized by anti-Epstein-Barr virus IgA and high cellular viral loads with restricted transcription.
AIDS (London, England) 2007;21(16):2141-9.
2007: Silvia de Sanjosé; Ramón Bosch; Tabitha Schouten; Sandra A W M Verkuijlen; Alexandra Nieters; Lenka Foretova; Marc Maynadié; Pier Luigi Cocco; Anthony Staines; Nikolaus Becker; Paul Brennan; Yolanda Benavente; Paolo Boffetta; Chris Jlm Meijer; Jaap Middeldorp
Epstein-Barr virus infection and risk of lymphoma: immunoblot analysis of antibody responses against EBV-related proteins in a large series of lymphoma subjects and matched controls.
International journal of cancer. Journal international du cancer 2007;121(8):1806-12.
2007: Martin Rowe; Britt Glaunsinger; Daphne van Leeuwen; Jianmin Zuo; David Sweetman; Don Ganem; Jaap Middeldorp; Emmanuel J H J Wiertz; Maaike E Ressing
Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3366-71.
2006: Servi J C Stevens; Christian M Zwaan; Sandra A W M Verkuijlen; Jaap Middeldorp
Epstein-Barr virus (EBV) serology for predicting distant metastases in a white juvenile patient with nasopharyngeal carcinoma and no clinical response to EBV lytic induction therapy.
Head & neck 2006;28(11):1040-5.
2006: C Hennard; T Pfuhl; Maike Buettner; K-F Becker; T Knöfel; Jaap Middeldorp; Elisabeth Kremmer; Gerald Niedobitek; Friedrich A Grässer
The antibody 2B4 directed against the Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) detects MAGE-4: implications for studies on the EBV association of human cancers.
The Journal of pathology 2006;209(4):430-5.
2006: Servi J C Stevens; Sandra A W M Verkuijlen; Bambang Hariwiyanto; Dewi K Paramita; Jajah Fachiroh; Marlinda Adham; I Bing Tan; Sofia M Haryana; Jaap Middeldorp
Noninvasive diagnosis of nasopharyngeal carcinoma: nasopharyngeal brushings reveal high Epstein-Barr virus DNA load and carcinoma-specific viral BARF1 mRNA.
International journal of cancer. Journal international du cancer 2006;119(3):608-14.
2006: Jajah Fachiroh; Dewi K Paramita; Bambang Hariwiyanto; Ahmad Harijadi; H L Dahlia; S R Indrasari; H Kusumo; Y S Zeng; Tabitha Schouten; S Mubarika; Jaap Middeldorp
Single-assay combination of Epstein-Barr Virus (EBV) EBNA1- and viral capsid antigen-p18-derived synthetic peptides for measuring anti-EBV immunoglobulin G (IgG) and IgA antibody levels in sera from nasopharyngeal carcinoma patients: options for field screening.
Journal of clinical microbiology 2006;44(4):1459-67.
2006: Cécile Keryer-Bibens; Catherine Pioche-Durieu; Cécile Villemant; Sylvie Souquère; Nozomu Nishi; Mitsuomi Hirashima; Jaap Middeldorp; Pierre Busson
Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9.
BMC cancer 2006;6():283.
2006: Josine van Beek; Axel zur Hausen; Sander N Snel; Johannes Berkhof; Elma Klein Kranenbarg; Cornelis J H van de Velde; Adriaan J C van den Brule; Jaap Middeldorp; Chris J L M Meijer; Elisabeth Bloemena
Morphological evidence of an activated cytotoxic T-cell infiltrate in EBV-positive gastric carcinoma preventing lymph node metastases.
The American journal of surgical pathology 2006;30(1):59-65.
2005: Julien Batisse; Evelyne Manet; Jaap Middeldorp; Alain Sergeant; Gruffat Henri
Epstein-Barr virus mRNA export factor EB2 is essential for intranuclear capsid assembly and production of gp350.
Journal of virology 2005;79(22):14102-11.
2005: Catherine Pioche-Durieu; Cécile Keryer; Sylvie Souquère; Jacques Bosq; Wolfgang Faigle; Damarys Loew; Mitsuomi Hirashima; Nozomu Nishi; Jaap Middeldorp; Pierre Busson
In nasopharyngeal carcinoma cells, Epstein-Barr virus LMP1 interacts with galectin 9 in membrane raft elements resistant to simvastatin.
Journal of virology 2005;79(21):13326-37.
2005: Servi J C Stevens; Sandra A W M Verkuijlen; Bambang Hariwiyanto; Jajah Fachiroh; Dewi K Paramita; I Bing Tan; Sofia M Haryana; Jaap Middeldorp
Diagnostic value of measuring Epstein-Barr virus (EBV) DNA load and carcinoma-specific viral mRNA in relation to anti-EBV immunoglobulin A (IgA) and IgG antibody levels in blood of nasopharyngeal carcinoma patients from Indonesia.
Journal of clinical microbiology 2005;43(7):3066-73.
2005: Joost Oudejans; Ahmad Harijadi; Saskia A G M Cillessen; Pierre Busson; I Bing Tan; Danny F Dukers; Wim Vos; Bambang Hariwiyanto; Jaap Middeldorp; Chris J L M Meijer
Absence of caspase 3 activation in neoplastic cells of nasopharyngeal carcinoma biopsies predicts rapid fatal outcome.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(7):877-85.
2005: Ciaran B J Woodman; Stuart I Collins; Nicol Vavrusova; Ankit Rao; Jaap Middeldorp; Zdenek Kolar; Angela Kumari; Paul Nelson; Lawrence S Young; Paul G Murray
Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study.
The Pediatric infectious disease journal 2005;24(6):498-502.
2005: Klaus Hamprecht; Mathias Pfau; Hans-Eberhard Schaller; Gerhard Jahn; Jaap Middeldorp; Hans-Oliver Rennekampff
Human cytomegalovirus infection of a severe-burn patient: evidence for productive self-limited viral replication in blood and lung.
Journal of clinical microbiology 2005;43(5):2534-6.
2005: Eri Seto; Lixin Yang; Jaap Middeldorp; Tzung-Shiahn Sheen; Jen-Yan Chen; Masashi Fukayama; Yoshito Eizuru; Tadamasa Ooka; Kenzo Takada
Epstein-Barr virus (EBV)-encoded BARF1 gene is expressed in nasopharyngeal carcinoma and EBV-associated gastric carcinoma tissues in the absence of lytic gene expression.
Journal of medical virology 2005;76(1):82-8.
2005: Mireille de Turenne-Tessier; Pierre Jolicoeur; Jaap Middeldorp; Tadamasa Ooka
Expression and analysis of the Epstein-Barr virus BARF1-encoded protein from a tetracycline-regulatable adenovirus system.
Virus research 2005;109(1):9-18.
2005: Hela Karray; W Ayadi; L Fki; Adnane Hammami; Jamel Daoud; Mohamed Drira; Mounir Frikha; Rachid Jlidi; Jaap Middeldorp
Comparison of three different serological techniques for primary diagnosis and monitoring of nasopharyngeal carcinoma in two age groups from Tunisia.
Journal of medical virology 2005;75(4):593-602.
2005: Abdelmajid Khabir; Hela Karray; Sandrine Rodriguez; Mathieu Rosé; Jamel Daoud; Mounir Frikha; Tahia Boudawara; Jaap Middeldorp; Rachid Jlidi; Pierre Busson
EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in north African nasopharyngeal carcinomas.
Virology journal 2005;2():39.
2005: Servi J C Stevens; Antoinette A T P Brink; Jaap Middeldorp
Profiling of Epstein-Barr virus latent RNA expression in clinical specimens by gene-specific multiprimed cDNA synthesis and PCR.
Methods in molecular biology (Clifton, N.J.) 2005;292():27-38.
2005: Servi J C Stevens; Sandra A W M Verkuijlen; Jaap Middeldorp
Quantitative detection of Epstein-Barr virus DNA in clinical specimens by rapid real-time PCR targeting a highly conserved region of EBNA-1.
Methods in molecular biology (Clifton, N.J.) 2005;292():15-26.
2004: D Michiel Pegtel; Jaap Middeldorp; David A Thorley-Lawson
Epstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriers.
Journal of virology 2004;78(22):12613-24.
2004: John Sears; Maki Ujihara; Samantha Wong; Christopher Ott; Jaap Middeldorp; Ashok Aiyar
The amino terminus of Epstein-Barr Virus (EBV) nuclear antigen 1 contains AT hooks that facilitate the replication and partitioning of latent EBV genomes by tethering them to cellular chromosomes.
Journal of virology 2004;78(21):11487-505.
2004: Klaus Hamprecht; Jens Maschmann; Denise Müller; Klaus Dietz; Ingo Besenthal; Rangmar Goelz; Jaap Middeldorp; Christian P Speer; Gerhard Jahn
Cytomegalovirus (CMV) inactivation in breast milk: reassessment of pasteurization and freeze-thawing.
Pediatric research 2004;56(4):529-35.
2004: Jajah Fachiroh; Tabitha Schouten; Bambang Hariwiyanto; Dewi K Paramita; Ahmad Harijadi; Sofia M Haryana; Mun-Hon Ng; Jaap Middeldorp
Molecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjects.
The Journal of infectious diseases 2004;190(1):53-62.
2004: Jeffery L Kutok; Sherry Klumpp; Meredith Simon; John J MacKey; Vuong Nguyen; Jaap Middeldorp; Jon C Aster; Fred Wang
Molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques.
Journal of virology 2004;78(7):3455-61.
2004: Josine van Beek; Axel zur Hausen; Elma Klein Kranenbarg; Cornelis J H van de Velde; Jaap Middeldorp; Adriaan J C van den Brule; Chris J L M Meijer; Elisabeth Bloemena
EBV-positive gastric adenocarcinomas: a distinct clinicopathologic entity with a low frequency of lymph node involvement.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(4):664-70.
2004: Donna Hochberg; Jaap Middeldorp; Michelle D Catalina; John L Sullivan; Katherine Luzuriaga; David A Thorley-Lawson
Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):239-44.
2003: Marcel W Bekkenk; Maarten H Vermeer; Chris J L M Meijer; Patty M Jansen; Jaap Middeldorp; Servi J C Stevens; Rein Willemze
EBV-positive cutaneous B-cell lymphoproliferative disease after imatinib mesylate.
Blood 2003;102(12):4243.
2003: Josine van Beek; Antoinette A T P Brink; Marcel B H J Vervoort; Mireille J M van Zijp; Chris J L M Meijer; Adriaan J C van den Brule; Jaap Middeldorp
In vivo transcription of the Epstein-Barr virus (EBV) BamHI-A region without associated in vivo BARF0 protein expression in multiple EBV-associated disorders.
The Journal of general virology 2003;84(Pt 10):2647-59.
2003: James Flanagan; Jaap Middeldorp; Tom Sculley
Localization of the Epstein-Barr virus protein LMP 1 to exosomes.
The Journal of general virology 2003;84(Pt 7):1871-9.
2003: Giuseppe Gerna; Daniele Lilleri; Fausto Baldanti; Maria Torsellini; Giovanna Giorgiani; Marco Zecca; Piero De Stefano; Jaap Middeldorp; Franco Locatelli; Maria Grazia Revello
Human cytomegalovirus immediate-early mRNAemia versus pp65 antigenemia for guiding pre-emptive therapy in children and young adults undergoing hematopoietic stem cell transplantation: a prospective, randomized, open-label trial.
Blood 2003;101(12):5053-60.
2003: Maria Grazia Revello; Daniele Lilleri; Maurizio Zavattoni; Milena Furione; Jaap Middeldorp; Giuseppe Gerna
Prenatal diagnosis of congenital human cytomegalovirus infection in amniotic fluid by nucleic acid sequence-based amplification assay.
Journal of clinical microbiology 2003;41(4):1772-4.
2003: Shao-An Xue; MD Jones; Qi-Long Lu; Jaap Middeldorp; shao-an xue
Genetic diversity: frameshift mechanisms alter coding of a gene (Epstein-Barr virus LF3 gene) that contains multiple 102-base-pair direct sequence repeats.
Molecular and cellular biology 2003;23(6):2192-201.
2003: Erik A M Verschuuren; Wim van Der Bij; Wim de Boer; Wim Timens; Jaap Middeldorp; T Hauw The
Quantitative Epstein-Barr virus (EBV) serology in lung transplant recipients with primary EBV infection and/or post-transplant lymphoproliferative disease.
Journal of medical virology 2003;69(2):258-66.
2003: taco uil; Toshiro Seki; Igor Dmitriev; Elena Kashentseva; Joanne T Douglas; Marianne G Rots; Jaap Middeldorp; David T Curiel
Generation of an adenoviral vector containing an addition of a heterologous ligand to the serotype 3 fiber knob.
Cancer gene therapy 2003;10(2):121-4.
2003: Jaap Middeldorp; Antoinette A T P Brink; Adriaan J C van den Brule; Chris J L M Meijer
Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders.
Critical reviews in oncology/hematology 2003;45(1):1-36.
2002: Kathrin Herrmann; Phroso Frangou; Jaap Middeldorp; Gerald Niedobitek
Epstein-Barr virus replication in tongue epithelial cells.
The Journal of general virology 2002;83(Pt 12):2995-8.
2002: Joost Oudejans; Hari Harijadi; J Alain Kummer; I Bing Tan; Elisabeth Bloemena; Jaap Middeldorp; Bellinda A Bladergroen; Danny F Dukers; Wim Vos; Chris J L M Meijer
High numbers of granzyme B/CD8-positive tumour-infiltrating lymphocytes in nasopharyngeal carcinoma biopsies predict rapid fatal outcome in patients treated with curative intent.
The Journal of pathology 2002;198(4):468-75.
2002: Servi J C Stevens; Sandra A W M Verkuijlen; Adriaan J C van den Brule; Jaap Middeldorp
Comparison of quantitative competitive PCR with LightCycler-based PCR for measuring Epstein-Barr virus DNA load in clinical specimens.
Journal of clinical microbiology 2002;40(11):3986-92.
2002: Jaap Middeldorp
Molecular diagnosis of viral infections in renal transplant recipients.
Current opinion in nephrology and hypertension 2002;11(6):665-72.
2002: Pauline Meij; Marcel B H J Vervoort; Elisabeth Bloemena; Tabitha Schouten; Cindy Schwartz; Seymour Grufferman; Richard F Ambinder; Jaap Middeldorp
Antibody responses to Epstein-Barr virus-encoded latent membrane protein-1 (LMP1) and expression of LMP1 in juvenile Hodgkin's disease.
Journal of medical virology 2002;68(3):370-7.
2002: Holger Hebart; T Rudolph; Juergen Loeffler; Jaap Middeldorp; Tatjana Ljubicic; Gerhard Jahn; Hermann Einsele
Evaluation of the NucliSens CMV pp67 assay for detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation.
Bone marrow transplantation 2002;30(3):181-7.
2002: Josine van Beek; Axel zur Hausen; Elma Klein Kranenbarg; Ralph J Warring; Elisabeth Bloemena; Mikael E Craanen; Cornelis J H van de Velde; Jaap Middeldorp; Chris J L M Meijer; Adriaan J C van den Brule
A rapid and reliable enzyme immunoassay PCR-based screening method to identify EBV-carrying gastric carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2002;15(8):870-7.
2002: Brian S N Blank; Pieter L Meenhorst; W Pauw; Jan W Mulder; WC van Dijk; Paul H M Smits; F Roeles; Jaap Middeldorp; Joep M A Lange
Detection of late pp67-mRNA by NASBA in peripheral blood for the diagnosis of human cytomegalovirus disease in AIDS patients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2002;25(1):29-38.
2002: John Woulfe; R Duke; Jaap Middeldorp; S Stevens; M Vervoort; M Hashimoto; Eliezer Masliah; Piu Chan; Donato A Di Monte; J William Langston; Giselle M Petzinger; H Hoogendoorn; David G Munoz
Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PD.
Neurology 2002;58(9):1435-6.
2002: Servi J C Stevens; Brian S N Blank; Paul H M Smits; Pieter L Meenhorst; Jaap Middeldorp
High Epstein-Barr virus (EBV) DNA loads in HIV-infected patients: correlation with antiretroviral therapy and quantitative EBV serology.
AIDS (London, England) 2002;16(7):993-1001.
2002: Pauline Meij; Ann Leen; Alan B Rickinson; Saertje Verkoeijen; Marcel B H J Vervoort; Elisabeth Bloemena; Jaap Middeldorp
Identification and prevalence of CD8(+) T-cell responses directed against Epstein-Barr virus-encoded latent membrane protein 1 and latent membrane protein 2.
International journal of cancer. Journal international du cancer 2002;99(1):93-9.
2002: Servi J C Stevens; Erik A M Verschuuren; Sandra A W M Verkuujlen; Adriaan J C van den Brule; Chris J L M Meijer; Jaap Middeldorp
Role of Epstein-Barr virus DNA load monitoring in prevention and early detection of post-transplant lymphoproliferative disease.
Leukemia & lymphoma 2002;43(4):831-40.
2002: Astrid E Greijer; Henriëtte M A Adriaanse; Chantal A J Dekkers; Jaap Middeldorp
Multiplex real-time NASBA for monitoring expression dynamics of human cytomegalovirus encoded IE1 and pp67 RNA.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2002;24(1-2):57-66.
2002: Erik A M Verschuuren; Servi J C Stevens; Gustaaf W van Imhoff; Jaap Middeldorp; Conny de Boer; Gerard H Koëter; T Hauw The; Wim van Der Bij
Treatment of posttransplant lymphoproliferative disease with rituximab: the remission, the relapse, and the complication.
Transplantation 2002;73(1):100-4.
2001: Valère J Goossens; Cornelis Vink; W Mullers; Jaap Middeldorp; Cathrien A Bruggeman
Different profiles of cytomegalovirus RNA transcripts and anti-cytomegalovirus IgM antibodies in renal transplant recipients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2001;23(1-2):87-95.
2001: Maria Grazia Revello; Daniele Lilleri; Maurizio Zavattoni; M Stronati; L Bollani; Jaap Middeldorp; Giuseppe Gerna
Human cytomegalovirus immediate-early messenger RNA in blood of pregnant women with primary infection and of congenitally infected newborns.
The Journal of infectious diseases 2001;184(8):1078-81.
2001: Ann Leen; Pauline Meij; IV Redchenko; Jaap Middeldorp; Elisabeth Bloemena; Alan B Rickinson; Neil Blake
Differential immunogenicity of Epstein-Barr virus latent-cycle proteins for human CD4(+) T-helper 1 responses.
Journal of virology 2001;75(18):8649-59.
2001: Astrid E Greijer; Henriëtte M A Adriaanse; M Kahl; NM Tacken; N Oldenburg; A Sijlmans; J M van de Crommert; Chantal A J Dekkers; P T Sillekens; Jaap Middeldorp
Quantitative competitive NASBA for measuring mRNA expression levels of the immediate early 1, late pp67, and immune evasion genes US3, US6 and US11 in cells infected with human cytomegalovirus.
Journal of virological methods 2001;96(2):133-47.
2001: Astrid E Greijer; Erik A M Verschuuren; Chantal A J Dekkers; Henriëtte M A Adriaanse; Wim van Der Bij; T Hauw The; Jaap Middeldorp
Expression dynamics of human cytomegalovirus immune evasion genes US3, US6, and US11 in the blood of lung transplant recipients.
The Journal of infectious diseases 2001;184(3):247-55.
2001: Antoinette A T P Brink; Chris J L M Meijer; J M Nicholls; Jaap Middeldorp; Adriaan J C van den Brule
Activity of the EBNA1 promoter associated with lytic replication (Fp) in Epstein-Barr virus associated disorders.
Molecular pathology : MP 2001;54(2):98-102.
2001: Servi J C Stevens; I Pronk; Jaap Middeldorp
Toward standardization of Epstein-Barr virus DNA load monitoring: unfractionated whole blood as preferred clinical specimen.
Journal of clinical microbiology 2001;39(4):1211-6.
2001: S A Morré; J van Beek; Christianne J M De Groot; Joep Killestein; C J Meijer; Chris H Polman; Paul Van Der Valk; Jaap Middeldorp; A J van Den Brule
Is Epstein-Barr virus present in the CNS of patients with MS?
Neurology 2001;56(5):692.
2001: Servi J C Stevens; Erik A M Verschuuren; I Pronk; Wim van Der Bij; M C Harmsen; T Hauw The; Chris J L M Meijer; Adriaan J C van den Brule; Jaap Middeldorp
Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients.
Blood 2001;97(5):1165-71.
2001: Pauline Meij; Elisabeth Bloemena; N Palmen; Antoinette A T P Brink; Marcel B H J Vervoort; Chris J L M Meijer; Jaap Middeldorp
Functional CD4(+) and CD8(+) T-cell responses induced by autologous mitomycin C treated Epstein-Barr virus transformed lymphoblastoid cell lines.
Cellular immunology 2001;208(1):25-33.
2001: Astrid E Greijer; Erik A M Verschuuren; M C Harmsen; Chantal A J Dekkers; Henriëtte M A Adriaanse; T Hauw The; Jaap Middeldorp
Direct quantification of human cytomegalovirus immediate-early and late mRNA levels in blood of lung transplant recipients by competitive nucleic acid sequence-based amplification.
Journal of clinical microbiology 2001;39(1):251-9.
2000: Giuseppe Gerna; Fausto Baldanti; Jaap Middeldorp; Daniele Lilleri
Use of CMV transcripts for monitoring of CMV infections in transplant recipients.
International journal of antimicrobial agents 2000;16(4):455-60.
2000: Marinus J Blok; Irmeli Lautenschlager; Valère J Goossens; Jaap Middeldorp; Cornelis Vink; K Höckerstedt; Cathrien A Bruggeman
Diagnostic implications of human cytomegalovirus immediate early-1 and pp67 mRNA detection in whole-blood samples from liver transplant patients using nucleic acid sequence-based amplification.
Journal of clinical microbiology 2000;38(12):4485-91.
2000: Pauline Meij; Marcel B H J Vervoort; Chris J L M Meijer; Elisabeth Bloemena; Jaap Middeldorp
Production monitoring and purification of EBV encoded latent membrane protein 1 expressed and secreted by recombinant baculovirus infected insect cells.
Journal of virological methods 2000;90(2):193-204.
2000: Pauline Meij; Marcel B H J Vervoort; K de Gooijer; Elisabeth Bloemena; Chris J L M Meijer; Jaap Middeldorp
Bioreactor-scale production and one-step purification of Epstein-Barr nuclear antigen 1 expressed in baculovirus-infected insect cells.
Protein expression and purification 2000;20(2):324-33.
2000: N Oldenburg; K M Lam; M A Khan; B Top; NM Tacken; A McKie; Ghada W Mikhail; Jaap Middeldorp; A Wright; Nicholas R Banner; Magdi Yacoub
Evaluation of human cytomegalovirus gene expression in thoracic organ transplant recipients using nucleic acid sequence-based amplification.
Transplantation 2000;70(8):1209-15.
2000: Astrid E Greijer; Chantal A J Dekkers; Jaap Middeldorp
Human cytomegalovirus virions differentially incorporate viral and host cell RNA during the assembly process.
Journal of virology 2000;74(19):9078-82.
2000: J H Li; D Huang; B F Sun; X Zhang; Jaap Middeldorp; H Klamut; F F Liu
Efficacy of ionizing radiation combined with adenoviral p53 therapy in EBV-positive nasopharyngeal carcinoma.
International journal of cancer. Journal international du cancer 2000;87(4):606-10.
2000: Jennifer Webster-Cyriaque; Jaap Middeldorp; Nancy Raab-Traub
Hairy leukoplakia: an unusual combination of transforming and permissive Epstein-Barr virus infections.
Journal of virology 2000;74(16):7610-8.
2000: Danny F Dukers; Pauline Meij; Marcel B H J Vervoort; Wim Vos; Rik J Scheper; Chris J L M Meijer; Elisabeth Bloemena; Jaap Middeldorp
Direct immunosuppressive effects of EBV-encoded latent membrane protein 1.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):663-70.
2000: Danny F Dukers; Joost Oudejans; Elisabeth H Jaspars; M Gras; Wim Vos; Jaap Middeldorp; Chris J L M Meijer; Elisabeth Bloemena
All infiltrating T-lymphocytes in Hodgkin's disease express immunohistochemically detectable T-cell receptor zeta-chains in situ.
Histopathology 2000;36(6):544-50.
2000: Axel zur Hausen; Antoinette A T P Brink; Mikael E Craanen; Jaap Middeldorp; Chris J L M Meijer; Adriaan J C van den Brule
Unique transcription pattern of Epstein-Barr virus (EBV) in EBV-carrying gastric adenocarcinomas: expression of the transforming BARF1 gene.
Cancer research 2000;60(10):2745-8.
2000: Giuseppe Gerna; Fausto Baldanti; Daniele Lilleri; Maurizio Parea; Emilio Paolo Alessandrino; A Pagani; Franco Locatelli; Jaap Middeldorp; Maria Grazia Revello
Human cytomegalovirus immediate-early mRNA detection by nucleic acid sequence-based amplification as a new parameter for preemptive therapy in bone marrow transplant recipients.
Journal of clinical microbiology 2000;38(5):1845-53.
2000: Valère J Goossens; Marinus J Blok; Maarten H L Christiaans; Peter Sillekens; Jaap Middeldorp; Cathrien A Bruggeman
Early detection of cytomegalovirus in renal transplant recipients: comparison of PCR, NASBA, pp65 antigenemia, and viral culture.
Transplantation proceedings 2000;32(1):155-8.
2000: Marinus J Blok; Irmeli Lautenschlager; Maarten H L Christiaans; Johannes P van Hooff; Valère J Goossens; Jaap Middeldorp; Peter Sillekens; K Höckerstedt; Cathrien A Bruggeman
Sensitive detection of cytomegalovirus infection in transplant recipients using nucleic acid sequence-based amplification.
Transplantation proceedings 2000;32(1):149-51.
2000: Danny F Dukers; Lies H Jaspars; Wim Vos; Joost Oudejans; D Hayes; Saskia A G M Cillessen; Jaap Middeldorp; Chris J L M Meijer
Quantitative immunohistochemical analysis of cytokine profiles in Epstein-Barr virus-positive and -negative cases of Hodgkin's disease.
The Journal of pathology 2000;190(2):143-9.
1999: Servi J C Stevens; Marcel B H J Vervoort; Adriaan J C van den Brule; Pieter L Meenhorst; Chris J L M Meijer; Jaap Middeldorp
Monitoring of epstein-barr virus DNA load in peripheral blood by quantitative competitive PCR.
Journal of clinical microbiology 1999;37(9):2852-7.
1999: Marinus J Blok; Maarten H L Christiaans; Valère J Goossens; Johannes P van Hooff; Peter Sillekens; Jaap Middeldorp; Cathrien A Bruggeman
Early detection of human cytomegalovirus infection after kidney transplantation by nucleic acid sequence-based amplification.
Transplantation 1999;67(9):1274-7.
1999: Pauline Meij; Marcel B H J Vervoort; J Aarbiou; P van Dissel; arjen brink; Elisabeth Bloemena; Chris J L M Meijer; Jaap Middeldorp
Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases.
The Journal of infectious diseases 1999;179(5):1108-15.
1999: D P Hayes; Antoinette A T P Brink; Marcel B H J Vervoort; Jaap Middeldorp; Chris J L M Meijer; Adriaan J C van den Brule
Expression of Epstein-Barr virus (EBV) transcripts encoding homologues to important human proteins in diverse EBV associated diseases.
Molecular pathology : MP 1999;52(2):97-103.
1999: Giuseppe Gerna; Fausto Baldanti; Jaap Middeldorp; Milena Furione; Maurizio Zavattoni; Daniele Lilleri; Maria Grazia Revello
Clinical significance of expression of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification.
Journal of clinical microbiology 1999;37(4):902-11.
1999: Marinus J Blok; Irmeli Lautenschlager; Maarten H L Christiaans; Johannes P van Hooff; Valère J Goossens; Jaap Middeldorp; Peter Sillekens; A Ramon; K Höckerstedt; Cathrien A Bruggeman
Nucleic acid sequence-based amplification: a new technique for monitoring cytomegalovirus infection in transplant recipients.
Transplantation proceedings 1999;31(1-2):308-9.
1999: Valère J Goossens; Marinus J Blok; Maarten H L Christiaans; Johannes P van Hooff; Peter Sillekens; K Höckerstedt; Irmeli Lautenschlager; Jaap Middeldorp; Cathrien A Bruggeman
Diagnostic value of nucleic-acid-sequence- based amplification for the detection of cytomegalovirus infection in renal and liver transplant recipients.
Intervirology 1999;42(5-6):373-81.
1999: Astrid E Greijer; J M van de Crommert; S J Stevens; Jaap Middeldorp
Molecular fine-specificity analysis of antibody responses to human cytomegalovirus and design of novel synthetic-peptide-based serodiagnostic assays.
Journal of clinical microbiology 1999;37(1):179-88.
1998: Antoinette A T P Brink; Marcel B H J Vervoort; Jaap Middeldorp; Chris J L M Meijer; Adriaan J C van den Brule
Nucleic acid sequence-based amplification, a new method for analysis of spliced and unspliced Epstein-Barr virus latent transcripts, and its comparison with reverse transcriptase PCR.
Journal of clinical microbiology 1998;36(11):3164-9.
1998: J X Zhang; H L Chen; Y S Zong; Kwok-Hung Chan; J Nicholls; Jaap Middeldorp; Jonathan S T Sham; B E Griffin; Mun-Hon Ng
Epstein-Barr virus expression within keratinizing nasopharyngeal carcinoma.
Journal of medical virology 1998;55(3):227-33.
1998: K M Lam; N Oldenburg; M A Khan; V Gaylore; Ghada W Mikhail; P D Strouhal; Jaap Middeldorp; Nicholas R Banner; Magdi Yacoub
Significance of reverse transcription polymerase chain reaction in the detection of human cytomegalovirus gene transcripts in thoracic organ transplant recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1998;17(6):555-65.
1998: Marinus J Blok; Valère J Goossens; S J Vanherle; B Top; NM Tacken; Jaap Middeldorp; Maarten H L Christiaans; Johannes P van Hooff; Cathrien A Bruggeman
Diagnostic value of monitoring human cytomegalovirus late pp67 mRNA expression in renal-allograft recipients by nucleic acid sequence-based amplification.
Journal of clinical microbiology 1998;36(5):1341-6.
1998: E H Spaeny-Dekking; W L Hanna; Angela M Wolbink; Peter C Wever; J A Kummer; A J Kummer; A J Swaak; Jaap Middeldorp; H G Huisman; CJ Froelich; C Erik Hack
Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3610-6.
1998: Mei-Ru Chen; J F Yang; Cheng-Wen Wu; Jaap Middeldorp; Jen-Yang Chen
Physical association between the EBV protein EBNA-1 and P32/TAP/hyaluronectin.
Journal of biomedical science 1998;5(3):173-9.
1998: Marinus J Blok; Maarten H L Christiaans; Valère J Goossens; Johannes P van Hooff; B Top; Jaap Middeldorp; Cathrien A Bruggeman
Evaluation of a new method for early detection of active cytomegalovirus infections. A study in kidney transplant recipients.
Transplant international : official journal of the European Society for Organ Transplantation 1998;11 Suppl 1():S107-9.
1997: Y Zeng; Jaap Middeldorp; J J Madjar; Tadamasa Ooka
A major DNA binding protein encoded by BALF2 open reading frame of Epstein-Barr virus (EBV) forms a complex with other EBV DNA-binding proteins: DNAase, EA-D, and DNA polymerase.
Virology 1997;239(2):285-95.
1997: Antoinette A T P Brink; Danny F Dukers; Adriaan J C van den Brule; Joost Oudejans; Jaap Middeldorp; Chris J L M Meijer; M Jiwa
Presence of Epstein-Barr virus latency type III at the single cell level in post-transplantation lymphoproliferative disorders and AIDS related lymphomas.
Journal of clinical pathology 1997;50(11):911-8.
1997: Yanshu Wang; J E Finan; Jaap Middeldorp; S Diane Hayward
P32/TAP, a cellular protein that interacts with EBNA-1 of Epstein-Barr virus.
Virology 1997;236(1):18-29.
1997: Joost Oudejans; N Mehdi Jiwa; J Alain Kummer; Gert Ossenkoppele; P van Heerde; Joke W Baars; Philip M Kluin; Johanna C Kluin-Nelemans; Paulus van Diest; Jaap Middeldorp; Chris J L M Meijer
Activated cytotoxic T cells as prognostic marker in Hodgkin's disease.
Blood 1997;89(4):1376-82.
1996: Joost Oudejans; Danny F Dukers; N Mehdi Jiwa; Adriaan J C van den Brule; F A Grässer; P C de Bruin; A Horstman; W Vos; J van Gorp; Jaap Middeldorp; Chris J L M Meijer
Expression of epstein-barr virus encoded nuclear antigen 1 in benign and malignant tissues harbouring EBV.
Journal of clinical pathology 1996;49(11):897-902.
1996: T R Serio; A Angeloni; J L Kolman; Lyn Gradoville; R Sun; D A Katz; W Van Grunsven; Jaap Middeldorp; I G Miller
Two 21-kilodalton components of the Epstein-Barr virus capsid antigen complex and their relationship to ZEBRA-associated protein p21 (ZAP21).
Journal of virology 1996;70(11):8047-54.
1995: Hans-Joachim Wagner; Mathias W Hornef; Jaap Middeldorp; Holger Kirchner
Characteristics of viral protein expression by Epstein-Barr virus-infected B cells in peripheral blood of patients with infectious mononucleosis.
Clinical and diagnostic laboratory immunology 1995;2(6):696-9.
1995: Mats Ohlin; B Plachter; V A Sundqvist; P G Steenbakkers; Jaap Middeldorp; Carl A K Borrebaeck
Human antibody reactivity against the lower matrix protein (pp65) produced by cytomegalovirus.
Clinical and diagnostic laboratory immunology 1995;2(3):325-9.
1995: N Mehdi Jiwa; Joost Oudejans; Danny F Dukers; W Vos; A Horstman; Paul Van Der Valk; Jaap Middeldorp; Jan M M Walboomers; Chris J L M Meijer
Immunohistochemical demonstration of different latent membrane protein-1 epitopes of Epstein-Barr virus in lymphoproliferative diseases.
Journal of clinical pathology 1995;48(5):438-42.
1994: Mario U Mondelli; Antonella Cerino; Piet J Boender; P Oudshoorn; Jaap Middeldorp; C Fipaldini; Nicola La Monica; W Habets
Significance of the immune response to a major, conformational B-cell epitope on the hepatitis C virus NS3 region defined by a human monoclonal antibody.
Journal of virology 1994;68(8):4829-36.
1994: W M van Grunsven; Willy Spaan; Jaap Middeldorp
Localization and diagnostic application of immunodominant domains of the BFRF3-encoded Epstein-Barr virus capsid protein.
The Journal of infectious diseases 1994;170(1):13-9.
1994: Sing Hiem Yap; M Willems; Joost J van den Oord; W Habets; Jaap Middeldorp; J A Hellings; Frederik Nevens; Han Moshage; Valeer Desmet; Johan Fevery
Detection of hepatitis C virus antigen by immuno-histochemical staining: a histological marker of hepatitis C virus infection.
Journal of hepatology 1994;20(2):275-81.
1993: S L Li; H Feichtinger; Ephata Kaaya; P Migliorini; P Putkonen; Gunnel Biberfeld; Jaap Middeldorp; Peter Biberfeld; I Ernberg
Expression of Epstein-Barr-virus-related nuclear antigens and B-cell markers in lymphomas of SIV-immunosuppressed monkeys.
International journal of cancer. Journal international du cancer 1993;55(4):609-15.
1993: R Lau; Jaap Middeldorp; Paul J Farrell
Epstein-Barr virus gene expression in oral hairy leukoplakia.
Virology 1993;195(2):463-74.
1993: M R Chen; Jaap Middeldorp; S Diane Hayward
Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure.
Journal of virology 1993;67(8):4875-85.
1993: W M van Grunsven; E C van Heerde; H J de Haard; Willy Spaan; Jaap Middeldorp
Gene mapping and expression of two immunodominant Epstein-Barr virus capsid proteins.
Journal of virology 1993;67(7):3908-16.
1993: W M van Grunsven; A Nabbe; Jaap Middeldorp
Identification and molecular characterization of two diagnostically relevant marker proteins of the Epstein-Barr virus capsid antigen complex.
Journal of medical virology 1993;40(2):161-9.
1992: Martin Hessing; H B van Schijndel; W M van Grunsven; H Wolf; Jaap Middeldorp
Purification and quantification of recombinant Epstein-Barr viral glycoproteins gp350/220 from Chinese hamster ovary cells.
Journal of chromatography 1992;599(1-2):267-72.
1991: T F Schwarz; Susanne Modrow; B Hottenträger; B Höflacher; Gabriele Jäger; W Scharti; R Sumazakl; Hans Wolf; Jaap Middeldorp; Michael Roggendorf
New oligopeptide immunoglobulin G test for human parvovirus B19 antibodies.
Journal of clinical microbiology 1991;29(3):431-5.
1990: T F Schwarz; Michael Roggendorf; B Hottenträger; Susanne Modrow; F Deinhardt; Jaap Middeldorp
Immunoglobulins in the prophylaxis of parvovirus B19 infection.
The Journal of infectious diseases 1990;162(5):1214.
1988: A G Skar; Jaap Middeldorp; T Gundersen; H Rollag; M Degrè
Rapid diagnosis of genital herpes simplex infection by an indirect ELISA method.
NIPH annals 1988;11(2):59-65.
1988: Jaap Middeldorp; P Herbrink
Epstein-Barr virus specific marker molecules for early diagnosis of infectious mononucleosis.
Journal of virological methods 1988;21(1-4):133-46.
1988: F Wielaard; J Scherders; C Dagelinckx; Jaap Middeldorp; L J Sabbe; C Van Belzen
Development of an antibody-capture IgM-enzyme-linked immunosorbent assay for diagnosis of acute Epstein-Barr virus infections.
Journal of virological methods 1988;21(1-4):105-15.
1988: Jaap Middeldorp; R H Meloen
Epitope-mapping on the Epstein-Barr virus major capsid protein using systematic synthesis of overlapping oligopeptides.
Journal of virological methods 1988;21(1-4):147-59.
1987: Jaap Middeldorp; A M Hooymans; A J Kocken; A M van Loon; J A Emsbroek; R A Coutinho
A sensitive enzyme-linked immunosorbent assay for the detection of herpes simplex virus antigens.
Journal of virological methods 1987;17(1-2):159-74.
1986: Jaap Middeldorp; J Jongsma; T H The
Immunofluorescence for detection of antibodies against human cytomegalovirus-induced membrane antigens.
Journal of clinical microbiology 1986;24(3):405-13.
1986: Jaap Middeldorp; J Jongsma; T H The
Killing of human cytomegalovirus-infected fibroblasts by antiviral antibody and complement.
The Journal of infectious diseases 1986;153(1):48-55.
1985: A M Würsch; J W Gratama; Jaap Middeldorp; C Nissen; A Gratwohl; B Speck; J Jansen; Joseph D'Amaro; T H The; G C De Gast
The effect of cytomegalovirus infection on T lymphocytes after allogeneic bone marrow transplantation.
Clinical and experimental immunology 1985;62(2):278-87.
1985: J W Gratama; Jaap Middeldorp; L G Sinnige; J W van der Meer; Joseph D'Amaro; J Jansen; F E Zwaan; A Brand; Gijsbert C De Gast; T H The
Cytomegalovirus immunity in allogeneic marrow grafting.
Transplantation 1985;40(5):510-4.
1985: H W Roenhorst; A M Tegzess; J M Beelen; Jaap Middeldorp; T H The
HLA-DRw6 as a risk factor for active cytomegalovirus but not for herpes simplex virus infection after renal allograft transplantation.
British medical journal (Clinical research ed.) 1985;291(6496):619-22.
1985: Gijsbert C De Gast; Leo F Verdonck; Jaap Middeldorp; T H The; A Hekker; J A vd Linden; H A Kreeft; bert bast
Recovery of T cell subsets after autologous bone marrow transplantation is mainly due to proliferation of mature T cells in the graft.
Blood 1985;66(2):428-31.
1985: H W Roenhorst; J M Beelen; Jaap Middeldorp; J Schirm; A M Tegzess; T H The
Maintenance of cytomegalovirus (CMV) latency and host immune responses of long term renal allograft survivors. II. Secondary CMV infections associated with impaired in vitro proliferative responses to mitogens, allogeneic lymphocytes and CMV infected cells.
Clinical and experimental immunology 1985;61(1):72-9.
1985: Leo F Verdonck; Jaap Middeldorp; H A Kreeft; T H The; A Hekker; Gijsbert C De Gast
Primary cytomegalovirus infection and its prevention after autologous bone marrow transplantation.
Transplantation 1985;39(4):455-7.
1985: Jaap Middeldorp; J Jongsma; T H The
Cytomegalovirus early and late membrane antigens detected by antibodies in human convalescent sera.
Journal of virology 1985;54(1):240-4.
1985: H W Roenhorst; Jaap Middeldorp; J M Beelen; J Schirm; A M Tegzess; T H The
Maintenance of cytomegalovirus (CMV) latency and host immune responses of long term renal allograft survivors. I. Prolonged suppression of in vitro lymphocyte responses against CMV infected fibroblasts related to previous secondary CMV infection.
Clinical and experimental immunology 1985;59(3):709-15.
1984: Jaap Middeldorp; J Jongsma; A ter Haar; J Schirm; T H The
Detection of immunoglobulin M and G antibodies against cytomegalovirus early and late antigens by enzyme-linked immunosorbent assay.
Journal of clinical microbiology 1984;20(4):763-71.
1983: Jaap Middeldorp; Bernard Witholt
An in vitro system to study interactions between bacteria and epithelial cells at the molecular level.
Journal of general microbiology 1983;129(1):179-90.
1983: J Schirm; Jaap Middeldorp; H W Roenhorst; T H The
A stimulatory role for cytomegalovirus (CMV) antibodies in CMV-specific lymphocyte proliferation in vitro.
Intervirology 1983;20(2-3):114-22.
1981: Jaap Middeldorp; Bernard Witholt
K88-mediated binding of Escherichia coli outer membrane fragments to porcine intestinal epithelial cell brush borders.
Infection and immunity 1981;31(1):42-51.