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Paul Carr

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Sylvia H-C Yip; Gerhard Schenk; Paul D Carr; Jee-Loon Foo; Lawrence R Gahan; David L Ollis
Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme.
Jee-Loon Foo; Jackson Colin; Paul D Carr; Hye-Kyung Kim; Gerhard Schenk; Lawrence R Gahan; David L Ollis
Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme.
C J Jackson; J-L Foo; N Tokuriki; L Afriat; Paul D Carr; H-K Kim; G Schenk; D S Tawfik; D L Ollis
Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase.

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All Publications

2011: Sylvia H-C Yip; Gerhard Schenk; Paul D Carr; Jee-Loon Foo; Lawrence R Gahan; David L Ollis
Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme.
Protein engineering, design & selection : PEDS 2011;24(12):861-72.
2010: Jee-Loon Foo; Jackson Colin; Paul D Carr; Hye-Kyung Kim; Gerhard Schenk; Lawrence R Gahan; David L Ollis
Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme.
The Biochemical journal 2010;429(2):313-21.
2009: C J Jackson; J-L Foo; N Tokuriki; L Afriat; Paul D Carr; H-K Kim; G Schenk; D S Tawfik; D L Ollis
Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21631-6.
2009: Paul D Carr; David L Ollis
Alpha/beta hydrolase fold: an update.
Protein and peptide letters 2009;16(10):1137-48.
2008: Jackson Colin; Kieran S Hadler; Paul D Carr; Aaron J Oakley; Sylvia Yip; Gerhard Schenk; David L Ollis
Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 8):681-5.
2008: Jackson Colin; Jee-Loon Foo; Hye-Kyung Kim; Paul D Carr; Jian-Wei Liu; Geoffrey Salem; David L Ollis
In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase.
Journal of molecular biology 2008;375(5):1189-96.
2007: Jackson Colin; Paul D Carr; Jian-Wei Liu; Stephen J Watt; Jennifer L Beck; David L Ollis
The structure and function of a novel glycerophosphodiesterase from Enterobacter aerogenes.
Journal of molecular biology 2007;367(4):1047-62.
2007: D Verger; Paul D Carr; T Kwok; David L Ollis
Crystal structure of the N-terminal domain of the TyrR transcription factor responsible for gene regulation of aromatic amino acid biosynthesis and transport in Escherichia coli K12.
Journal of molecular biology 2007;367(1):102-12.
2006: Jackson Colin; Paul D Carr; Hye-Kyung Kim; Jian-Wei Liu; Paul Herrald; Natasa Mitić; Gerhard Schenk; Clyde Smith; David L Ollis
Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site.
The Biochemical journal 2006;397(3):501-8.
2006: Jackson Colin; Paul D Carr; Hye Kyung Kim; Jian Wei Liu; David L Ollis
The purification, crystallization and preliminary diffraction of a glycerophosphodiesterase from Enterobacter aerogenes.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 7):659-61.
2006: Paul D Carr; F Conlan; S Ford; David L Ollis; Ian G Young
An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 6):509-13.
2005: Jackson Colin; Hye-Kyung Kim; Paul D Carr; Jian-Wei Liu; David L Ollis
The structure of an enzyme-product complex reveals the critical role of a terminal hydroxide nucleophile in the bacterial phosphotriesterase mechanism.
Biochimica et biophysica acta 2005;1752(1):56-64.
2005: Yibin Xu; Daying Wen; Carmen Brown; Chun-Jung Chen; Paul D Carr; David L Ollis; Subhash G Vasudevan
Expression, purification and crystallization of the C-terminal domain of Escherichia coli adenylyltransferase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 7):663-5.
2005: Hye Kyung Kim; Jian Wei Liu; Paul D Carr; David L Ollis
Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 7):920-31.
2004: Yibin Xu; Rongguand Zhang; Andrzej Joachimiak; Paul D Carr; Thomas Huber; Subhash G Vasudevan; David L Ollis
Structure of the N-terminal domain of Escherichia coli glutamine synthetase adenylyltransferase.
Structure (London, England : 1993) 2004;12(5):861-9.
2004: Yibin Xu; Daying Wen; Paula Clancy; Paul D Carr; David L Ollis; Subhash G Vasudevan
Expression, purification, crystallization, and preliminary X-ray analysis of the N-terminal domain of Escherichia coli adenylyl transferase.
Protein expression and purification 2004;34(1):142-6.
2003: Yibin Xu; Paul D Carr; Paula Clancy; Mario Garcia-Dominguez; Karl Forchhammer; Francisco Florencio; Subhash G Vasudevan; Nicole Tandeau de Marsac; David L Ollis
The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2183-90.
2003: James M Murphy; Sally C Ford; Ursula M Wiedemann; Paul D Carr; David L Ollis; Ian G Young
A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5.
The Journal of biological chemistry 2003;278(12):10572-7.
2003: H Yang; Paul D Carr; Sean Yu McLoughlin; Jian-Wei Liu; Irene Horne; Xinghui Qiu; C M J Jeffries; Robyn J Russell; John G Oakeshott; David L Ollis
Evolution of an organophosphate-degrading enzyme: a comparison of natural and directed evolution.
Protein engineering 2003;16(2):135-45.
2002: Samir M Hamdan; Esther M Bulloch; Phillip R Thompson; Jennifer L Beck; Ji Yeon Yang; Jeffrey A Crowther; Penelope E Lilley; Paul D Carr; David L Ollis; Susan E Brown; Nicholas E Dixon
Hydrolysis of the 5'-p-nitrophenyl ester of TMP by the proofreading exonuclease (epsilon) subunit of Escherichia coli DNA polymerase III.
Biochemistry 2002;41(16):5266-75.
2002: Samir M Hamdan; Paul D Carr; Susan E Brown; David L Ollis; Nicholas E Dixon
Structural basis for proofreading during replication of the Escherichia coli chromosome.
Structure (London, England : 1993) 2002;10(4):535-46.
2001: Sonja E Gustin; A P Church; Sally C Ford; Derek A Mann; Paul D Carr; David L Ollis; Ian G Young
Expression, crystallization and derivatization of the complete extracellular domain of the beta(c) subunit of the human IL-5, IL-3 and GM-CSF receptors.
European journal of biochemistry / FEBS 2001;268(10):2905-11.
2001: Yibin Xu; Paul D Carr; Thomas Huber; Subhash G Vasudevan; David L Ollis
The structure of the PII-ATP complex.
European journal of biochemistry / FEBS 2001;268(7):2028-37.
2001: Paul D Carr; Sonja E Gustin; A P Church; James M Murphy; Sally C Ford; Derek A Mann; Donna Woltring; I Walker; David L Ollis; Ian G Young
Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration.
Cell 2001;104(2):291-300.
2000: A Robinson; K J Edwards; Paul D Carr; J D Barton; Gary Ewart; David L Ollis
Structure of the C123S mutant of dienelactone hydrolase (DLH) bound with the PMS moiety of the protease inhibitor phenylmethylsulfonyl fluoride (PMSF).
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1376-84.
2000: Samir M Hamdan; Susan E Brown; Phillip R Thompson; Ji Yeon Yang; Paul D Carr; David L Ollis; Gottfried Otting; Nicholas E Dixon
Preliminary X-ray crystallographic and NMR studies on the exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III.
Journal of structural biology 2000;131(2):164-9.
2000: Jian Wei Liu; D Verger; Paul D Carr; H Yang; David L Ollis
Expression, purification and preliminary crystallographic studies of a hyperthermophilic esterase from Archaeoglobus fulgidus.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 7):900-1.
1999: KH MacPherson; Paul D Carr; D Verger; T Kwok; Barrie E Davidson; David L Ollis
Crystallization of the N-terminal domain of the Escherichia coli regulatory protein TyrR.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 11):1923-4.
1999: Paul D Carr; D Verger; A R Ashton; David L Ollis
Chloroplast NADP-malate dehydrogenase: structural basis of light-dependent regulation of activity by thiol oxidation and reduction.
Structure (London, England : 1993) 1999;7(4):461-75.
1998: Yibin Xu; E Cheah; Paul D Carr; Wally C van Heeswijk; HV Westerhoff; Subhash G Vasudevan; David L Ollis
GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition.
Journal of molecular biology 1998;282(1):149-65.
1998: KH MacPherson; Yibin Xu; E Cheah; Paul D Carr; Wally C van Heeswijk; HV Westerhoff; E Luque; Subhash G Vasudevan; David L Ollis
Crystallization and preliminary X-ray analysis of Escherichia coli GlnK.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):996-8.
1998: KH MacPherson; A R Ashton; Paul D Carr; S J Trevanion; D Verger; David L Ollis
Crystallization and preliminary crystallographic studies of chloroplast NADP-dependent malate dehydrogenase from Flaveria bidentis.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 4):654-6.
1998: Yibin Xu; Paul D Carr; J Mitchell Guss; David L Ollis
The crystal structure of bikunin from the inter-alpha-inhibitor complex: a serine protease inhibitor with two Kunitz domains.
Journal of molecular biology 1998;276(5):955-66.
1996: R Jaggi; W Ybarlucea; E Cheah; Paul D Carr; K J Edwards; David L Ollis; Subhash G Vasudevan
The role of the T-loop of the signal transducing protein PII from Escherichia coli.
FEBS letters 1996;391(1-2):223-8.
1996: K J Edwards; P M Suffolk; Paul D Carr; M Megman; E Cheah; David L Ollis
Crystallization and preliminary X-ray diffraction studies of new crystal forms of Escherichia coli P(II) complexed with various ligands.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 4):738-42.
1996: Paul D Carr; E Cheah; P M Suffolk; Subhash G Vasudevan; Nicholas E Dixon; David L Ollis
X-ray structure of the signal transduction protein from Escherichia coli at 1.9 A.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 1):93-104.
1994: E Cheah; Paul D Carr; P M Suffolk; Subhash G Vasudevan; Nicholas E Dixon; David L Ollis
Structure of the Escherichia coli signal transducing protein PII.
Structure (London, England : 1993) 1994;2(10):981-90.
1994: J M Thorn; Paul D Carr; J W Chase; Nicholas E Dixon; David L Ollis
Crystallization and low temperature diffraction studies of the DNA binding domain of the single-stranded DNA binding protein from Escherichia coli.
Journal of molecular biology 1994;240(4):396-9.
1994: Subhash G Vasudevan; C Gedye; Nicholas E Dixon; E Cheah; Paul D Carr; P M Suffolk; P D Jeffrey; David L Ollis
Escherichia coli PII protein: purification, crystallization and oligomeric structure.
FEBS letters 1994;337(3):255-8.