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Diana Marie Downs

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TOP 3
Jennifer A Lambrecht; Jeffrey M Flynn; Diana Marie Downs
Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.
Jeffery M Boyd; James A Endrizzi; Trinity L Hamilton; Melissa R Christopherson; David W Mulder; Diana Marie Downs; John W Peters
FAD binding by ApbE protein from Salmonella enterica: a new class of FAD-binding proteins.
Jannell V Bazurto; Diana Marie Downs
Plasticity in the purine-thiamine metabolic network of Salmonella.

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All Publications

2012: Jennifer A Lambrecht; Jeffrey M Flynn; Diana Marie Downs
Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.
The Journal of biological chemistry 2012;287(5):3454-61.
2011: Jeffery M Boyd; James A Endrizzi; Trinity L Hamilton; Melissa R Christopherson; David W Mulder; Diana Marie Downs; John W Peters
FAD binding by ApbE protein from Salmonella enterica: a new class of FAD-binding proteins.
Journal of bacteriology 2011;193(4):887-95.
2011: Jannell V Bazurto; Diana Marie Downs
Plasticity in the purine-thiamine metabolic network of Salmonella.
Genetics 2011;187(2):623-31.
2010: Jennifer A Lambrecht; Beth Ann Browne; Diana Marie Downs
Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro.
The Journal of biological chemistry 2010;285(45):34401-7.
2010: Mark J Koenigsknecht; Luke A Fenlon; Diana Marie Downs
Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica.
Microbiology (Reading, England) 2010;156(Pt 3):950-9.
2009: Jeffrey A Lewis; Jeffrey M Boyd; Diana Marie Downs; Jorge C Escalante-Semerena
Involvement of the Cra global regulatory protein in the expression of the iscRSUA operon, revealed during studies of tricarballylate catabolism in Salmonella enterica.
Journal of bacteriology 2009;191(7):2069-76.
2009: Jeffrey M Boyd; Randy M Drevland; Diana Marie Downs; David E Graham
Archaeal ApbC/Nbp35 homologs function as iron-sulfur cluster carrier proteins.
Journal of bacteriology 2009;191(5):1490-7.
2009: N Cecilia Martinez-Gomez; Russell R Poyner; Steven O Mansoorabadi; George H Reed; Diana Marie Downs
Reaction of AdoMet with ThiC generates a backbone free radical.
Biochemistry 2009;48(2):217-9.
2009: Jeffrey M Boyd; Jamie L Sondelski; Diana Marie Downs
Bacterial ApbC protein has two biochemical activities that are required for in vivo function.
The Journal of biological chemistry 2009;284(1):110-8.
2009: Michael P Thorgersen; Diana Marie Downs
Oxidative stress and disruption of labile iron generate specific auxotrophic requirements in Salmonella enterica.
Microbiology (Reading, England) 2009;155(Pt 1):295-304.
2008: Michael P Thorgersen; Diana Marie Downs
Analysis of yggX and gshA mutants provides insights into the labile iron pool in Salmonella enterica.
Journal of bacteriology 2008;190(23):7608-13.
2008: N Cecilia Martinez-Gomez; Diana Marie Downs
ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis.
Biochemistry 2008;47(35):9054-6.
2008: Jeffrey M Boyd; Antonio J Pierik; Daili J A Netz; Roland Lill; Diana Marie Downs
Bacterial ApbC can bind and effectively transfer iron-sulfur clusters.
Biochemistry 2008;47(31):8195-202.
2008: Jeffrey M Boyd; Jeffrey A Lewis; Jorge C Escalante-Semerena; Diana Marie Downs
Salmonella enterica requires ApbC function for growth on tricarballylate: evidence of functional redundancy between ApbC and IscU.
Journal of bacteriology 2008;190(13):4596-602.
2008: Melissa R Christopherson; G E Schmitz; Diana Marie Downs
YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium.
Journal of bacteriology 2008;190(8):3057-62.
2008: Itzel Ramos; E I Vivas; Diana Marie Downs
Mutations in the tryptophan operon allow PurF-independent thiamine synthesis by altering flux in vivo.
Journal of bacteriology 2008;190(3):815-22.
2007: Michael P Thorgersen; Diana Marie Downs
Cobalt targets multiple metabolic processes in Salmonella enterica.
Journal of bacteriology 2007;189(21):7774-81.
2007: Mark J Koenigsknecht; Itzel Ramos; Diana Marie Downs
Glutamine phosphoribosylpyrophosphate amidotransferase-independent phosphoribosyl amine synthesis from ribose 5-phosphate and glutamine or asparagine.
The Journal of biological chemistry 2007;282(39):28379-84.
2006: Michael J Dougherty; Jeffrey M Boyd; Diana Marie Downs
Inhibition of fructose-1,6-bisphosphatase by aminoimidazole carboxamide ribotide prevents growth of Salmonella enterica purH mutants on glycerol.
The Journal of biological chemistry 2006;281(45):33892-9.
2006: Beth Ann Browne; A Itzel Ramos; Diana Marie Downs
PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase.
Journal of bacteriology 2006;188(19):6786-92.
2006: Michael J Dougherty; Diana Marie Downs
A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica.
Microbiology (Reading, England) 2006;152(Pt 8):2345-53.
2006: George E Schmitz; Diana Marie Downs
An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source.
Journal of bacteriology 2006;188(8):3126-9.
2006: Qiu Cui; Michael P Thorgersen; William M Westler; John Lute Markley; Diana Marie Downs
Solution structure of YggX: a prokaryotic protein involved in Fe(II) trafficking.
Proteins 2006;62(3):578-86.
2006: E Vivas; Elizabeth Skovran; Diana Marie Downs
Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo.
Journal of bacteriology 2006;188(3):1175-9.
2006: Diana Marie Downs
Understanding microbial metabolism.
Annual review of microbiology 2006;60():533-59.
2005: Diana Marie Downs; George E Schmitz; Elizabeth Skovran
Probing the complex system of metabolic integration.
Progress in nucleic acid research and molecular biology 2005;80():43-94.
2004: Elizabeth Skovran; Charles T Lauhon; Diana Marie Downs
Lack of YggX results in chronic oxidative stress and uncovers subtle defects in Fe-S cluster metabolism in Salmonella enterica.
Journal of bacteriology 2004;186(22):7626-34.
2004: Yan Zhang; Michael Dougherty; Diana Marie Downs; Steven E Ealick
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily.
Structure (London, England : 1993) 2004;12(10):1809-21.
2004: Norma C Martinez-Gomez; Matt Robers; Diana Marie Downs
Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily.
The Journal of biological chemistry 2004;279(39):40505-10.
2004: Michael J Dougherty; Diana Marie Downs
A mutant allele of rpoD results in increased conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine in Salmonella enterica.
Journal of bacteriology 2004;186(12):4034-7.
2004: Charles T Lauhon; Elizabeth Skovran; Hugo D Urbina; Diana Marie Downs; Larry E Vickery
Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo.
The Journal of biological chemistry 2004;279(19):19551-8.
2004: George Schmitz; Diana Marie Downs
Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium.
Journal of bacteriology 2004;186(3):803-10.
2003: Brian J Beck; Mike Huelsmeyer; Scott Paul; Diana Marie Downs
A mutation in the essential gene gmk (encoding guanlyate kinase) generates a requirement for adenine at low temperature in Salmonella enterica.
Journal of bacteriology 2003;185(22):6732-5.
2003: I Ramos; Diana Marie Downs
Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica.
Journal of bacteriology 2003;185(17):5125-32.
2003: Jeffrey A Gralnick; Diana Marie Downs
The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function.
The Journal of biological chemistry 2003;278(23):20708-15.
2003: Diana Marie Downs
Genomics and bacterial metabolism.
Current issues in molecular biology 2003;5(1):17-25.
2003: Michael Dougherty; Diana Marie Downs
The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains.
Journal of bacteriology 2003;185(1):332-9.
2003: Elizabeth Skovran; Diana Marie Downs
Lack of the ApbC or ApbE protein results in a defect in Fe-S cluster metabolism in Salmonella enterica serovar Typhimurium.
Journal of bacteriology 2003;185(1):98-106.
2002: Shara Allen; Julie L Zilles; Diana Marie Downs
Metabolic flux in both the purine mononucleotide and histidine biosynthetic pathways can influence synthesis of the hydroxymethyl pyrimidine moiety of thiamine in Salmonella enterica.
Journal of bacteriology 2002;184(22):6130-7.
2002: Aileen Rubio; Diana Marie Downs
Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme A elevation in Salmonella enterica serovar Typhimurium.
Journal of bacteriology 2002;184(10):2827-32.
2001: Jeffrey A Gralnick; Diana Marie Downs
Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):8030-5.
2001: Julie L Zilles; T J Kappock; J Stubbe; Diana Marie Downs
Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase.
Journal of bacteriology 2001;183(7):2234-40.
2000: Julie L Zilles; L R Croal; Diana Marie Downs
Action of the thiamine antagonist bacimethrin on thiamine biosynthesis.
Journal of bacteriology 2000;182(19):5606-10.
2000: Jeffrey A Gralnick; E Webb; B Beck; Diana Marie Downs
Lesions in gshA (Encoding gamma-L-glutamyl-L-cysteine synthetase) prevent aerobic synthesis of thiamine in Salmonella enterica serovar typhimurium LT2.
Journal of bacteriology 2000;182(18):5180-7.
2000: Elizabeth Skovran; Diana Marie Downs
Metabolic defects caused by mutations in the isc gene cluster in Salmonella enterica serovar typhimurium: implications for thiamine synthesis.
Journal of bacteriology 2000;182(14):3896-903.
2000: ME Frodyma; A Rubio; Diana Marie Downs
Reduced flux through the purine biosynthetic pathway results in an increased requirement for coenzyme A in thiamine synthesis in Salmonella enterica serovar typhimurium.
Journal of bacteriology 2000;182(1):236-40.
2000: Kathy R Claas; S Weber; Diana Marie Downs
Lesions in the nuo operon, encoding NADH dehydrogenase complex I, prevent PurF-independent thiamine synthesis and reduce flux through the oxidative pentose phosphate pathway in Salmonella enterica serovar typhimurium.
Journal of bacteriology 2000;182(1):228-32.
2000: Diana Marie Downs; J C Escalante-Semerena
Impact of genomics and genetics on the elucidation of bacterial metabolism.
Methods (San Diego, Calif.) 2000;20(1):47-54.
1999: Brian J Beck; Diana Marie Downs
A periplasmic location is essential for the role of the ApbE lipoprotein in thiamine synthesis in Salmonella typhimurium.
Journal of bacteriology 1999;181(23):7285-90.
1999: T Christian; Diana Marie Downs
Defects in pyruvate kinase cause a conditional increase of thiamine synthesis in Salmonella typhimurium.
Canadian journal of microbiology 1999;45(7):565-72.
1999: Tadhg P Begley; Diana Marie Downs; Steven E Ealick; Fred W McLafferty; A P Van Loon; S Taylor; N Campobasso; HJ Chiu; Cynthia Kinsland; Jason J Reddick; J Xi
Thiamin biosynthesis in prokaryotes.
Archives of microbiology 1999;171(5):293-300.
1999: JL Enos-Berlage; Diana Marie Downs
Biosynthesis of the pyrimidine moiety of thiamine independent of the PurF enzyme (Phosphoribosylpyrophosphate amidotransferase) in Salmonella typhimurium: incorporation of stable isotope-labeled glycine and formate.
Journal of bacteriology 1999;181(3):841-8.
1998: JL Enos-Berlage; M J Langendorf; Diana Marie Downs
Complex metabolic phenotypes caused by a mutation in yjgF, encoding a member of the highly conserved YER057c/YjgF family of proteins.
Journal of bacteriology 1998;180(24):6519-28.
1998: ME Frodyma; Diana Marie Downs
The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium.
Journal of bacteriology 1998;180(17):4757-9.
1998: Y S Kim; K Nosaka; Diana Marie Downs; June M Kwak; D Park; I K Chung; Hong Gil Nam
A Brassica cDNA clone encoding a bifunctional hydroxymethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase involved in thiamin biosynthesis.
Plant molecular biology 1998;37(6):955-66.
1998: E Webb; Kathy R Claas; Diana Marie Downs
thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium.
The Journal of biological chemistry 1998;273(15):8946-50.
1998: ME Frodyma; Diana Marie Downs
ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway.
The Journal of biological chemistry 1998;273(10):5572-6.
1998: Brian J Beck; Diana Marie Downs
The apbE gene encodes a lipoprotein involved in thiamine synthesis in Salmonella typhimurium.
Journal of bacteriology 1998;180(4):885-91.
1997: Brian J Beck; L E Connolly; A De Las Peñas; Diana Marie Downs
Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium.
Journal of bacteriology 1997;179(20):6504-8.
1997: L A Petersen; Diana Marie Downs
Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis.
Journal of bacteriology 1997;179(15):4894-900.
1997: E Webb; Kathy R Claas; Diana Marie Downs
Characterization of thiI, a new gene involved in thiazole biosynthesis in Salmonella typhimurium.
Journal of bacteriology 1997;179(13):4399-402.
1997: E Webb; Diana Marie Downs
Characterization of thiL, encoding thiamin-monophosphate kinase, in Salmonella typhimurium.
The Journal of biological chemistry 1997;272(25):15702-7.
1997: JL Enos-Berlage; Diana Marie Downs
Mutations in sdh (succinate dehydrogenase genes) alter the thiamine requirement of Salmonella typhimurium.
Journal of bacteriology 1997;179(12):3989-96.
1996: J L Zilles; Diana Marie Downs
A novel involvement of the PurG and PurI proteins in thiamine synthesis via the alternative pyrimidine biosynthetic (APB) pathway in Salmonella typhimurium.
Genetics 1996;144(3):883-92.
1996: L Petersen; Diana Marie Downs
Mutations in apbC (mrp) prevent function of the alternative pyrimidine biosynthetic pathway in Salmonella typhimurium.
Journal of bacteriology 1996;178(19):5676-82.
1996: L Petersen; J Enos-Berlage; Diana Marie Downs
Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium.
Genetics 1996;143(1):37-44.
1996: E Webb; F Febres; Diana Marie Downs
Thiamine pyrophosphate (TPP) negatively regulates transcription of some thi genes of Salmonella typhimurium.
Journal of bacteriology 1996;178(9):2533-8.
1996: J L Enos-Berlage; Diana Marie Downs
Involvement of the oxidative pentose phosphate pathway in thiamine biosynthesis in Salmonella typhimurium.
Journal of bacteriology 1996;178(5):1476-9.
1994: Diana Marie Downs; L Petersen
apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium.
Journal of bacteriology 1994;176(16):4858-64.
1993: Diana Marie Downs; Paul W Ludden; VK Shah
Accumulation of factor F395 in nifNE mutants of Klebsiella pneumoniae.
Canadian journal of microbiology 1993;39(3):351-4.
1992: Diana Marie Downs
Evidence for a new, oxygen-regulated biosynthetic pathway for the pyrimidine moiety of thiamine in Salmonella typhimurium.
Journal of bacteriology 1992;174(5):1515-21.
1991: Diana Marie Downs; John R Roth
Synthesis of thiamine in Salmonella typhimurium independent of the purF function.
Journal of bacteriology 1991;173(20):6597-604.
1990: Diana Marie Downs; Paul W Ludden; VK Shah
Synthesis of the iron-molybdenum cofactor of nitrogenase is inhibited by a low-molecular-weight metabolite of Klebsiella pneumoniae.
Journal of bacteriology 1990;172(10):6084-9.
1987: Diana Marie Downs; John R Roth
A novel P22 prophage in Salmonella typhimurium.
Genetics 1987;117(3):367-80.