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Arkaitz Carracedo

Research Profile

Living Beings

Mouse

Chemicals & Drugs

Anatomy

Tumor Cell Line

Physiology

Disorders

Procedures

Xenograft Model Antitumor Assays

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Publications

TOP 3
Elisa Da Silva-Ferrada; Carlos F de la Cruz-Herrera; Patrick England; Seth J Goldenberg; Valérie Lang; Fernando Lopitz-Otsoa; Itziar Martin-Ruiz; Carmen Rivas; Fabienne Aillet; Arkaitz Carracedo; Wendy Xolalpa; Manuel S Rodríguez
Analysis of SUMOylated proteins using SUMO-traps.
Arkaitz Carracedo; Lewis C Cantley; Pier Paolo Pandolfi
Cancer metabolism: fatty acid oxidation in the limelight.
Tewfik Hamidi; Ezequiel L Calvo; Carla E Cano; Arkaitz Carracedo; Jean-Charles Dagorn; Maria Noé Garcia; Sandro Goruppi; Daniel Grasso; Gwen Lomberk; Maria José Sandi; Raul Urrutia; Guillermo Velasco; Juan L Iovanna
NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells.

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All Publications

2013: Elisa Da Silva-Ferrada; Carlos F de la Cruz-Herrera; Patrick England; Seth J Goldenberg; Valérie Lang; Fernando Lopitz-Otsoa; Itziar Martin-Ruiz; Carmen Rivas; Fabienne Aillet; Arkaitz Carracedo; Wendy Xolalpa; Manuel S Rodríguez
Analysis of SUMOylated proteins using SUMO-traps.
Scientific reports 2013;3():1690.
2013: Arkaitz Carracedo; Lewis C Cantley; Pier Paolo Pandolfi
Cancer metabolism: fatty acid oxidation in the limelight.
Nature reviews. Cancer 2013;13(4):227-32.
2013: Tewfik Hamidi; Ezequiel L Calvo; Carla E Cano; Arkaitz Carracedo; Jean-Charles Dagorn; Maria Noé Garcia; Sandro Goruppi; Daniel Grasso; Gwen Lomberk; Maria José Sandi; Raul Urrutia; Guillermo Velasco; Juan L Iovanna
NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells.
Autophagy 2013;9(1):95-7.
2012: Tewfik Hamidi; Ezequiel L Calvo; Carla E Cano; Arkaitz Carracedo; Jean-Charles Dagorn; Maria Noé Garcia; Sandro Goruppi; Daniel Grasso; Gwen Lomberk; Maria José Sandi; Raul Urrutia; Guillermo Velasco; Juan L Iovanna
Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(19):5234-46.
2012: Arkaitz Carracedo; Vincent C J de Boer; Ainara Egia; Lydia S Finley; Zachary Gerhart-Hines; Marcia C Haigis; Keisuke Ito; Gaelle Laurent; Amy K Leliaert; Towia Libermann; Elefteria Maratos-Flier; Pere Puigserver; Andrea L Richardson; Zachary T Schafer; Su Jung Song; Maria Sundvall; Dror Weiss; Andrew C Adams; Manoj Bhasin; Pier P Pandolfi
A metabolic prosurvival role for PML in breast cancer.
The Journal of clinical investigation 2012;122(9):3088-100.
2012: Keisuke Ito; Chih-Hao Lee; Zachary T Schafer; Toshio Suda; Dror Weiss; Ugo Ala; Fumio Arai; David E Avigan; Arkaitz Carracedo; Ronald M Evans; Pier Paolo Pandolfi
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Nature medicine 2012;18(9):1350-8.
2012: Nieves Embade; David Fernández-Ramos; Shelly C Lu; Naiara Beraza; Francisco Javier Bustamante; Arkaitz Carracedo; Ana Belén de la Hoz; Nuria Martínez-López; José M Mato; Manuel S Rodríguez; Begoña Rodríguez-Iruretagoyena; Marcella Sini; Marta Varela-Rey; Ashwin Woodhoo; Dimitris P Xirodimas; Virginia Gutiérrez de Juan; María L Martínez-Chantar
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.
Hepatology (Baltimore, Md.) 2012;55(4):1237-48.
2012: Isabel Garcia-Cao; Carlotta Giorgi; Marcia C Haigis; Robin M Hobbs; Keisuke Ito; Gaelle Laurent; Dimitrios Anastasiou; Lewis C Cantley; Arkaitz Carracedo; Vincent C J de Boer; Paolo Pinton; Lucia Rameh; Atsuo T Sasaki; Min Sup Song; Matthew G Vander Heiden; Pier Paolo Pandolfi
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Cell 2012;149(1):49-62.
2012: Robert Kypta; Miguel Unda; Arkaitz Carracedo
Is the bench getting closer to the bedside in the war on cancer? A quick look at prostate cancer.
Frontiers in endocrinology 2012;3():53.
2011: Mar Lorente; Bárbara Meléndez; Manuela Mollejo; Fátima Rodríguez-Fornés; María Salazar; Sofia Torres; Juan A Barcia; Yolanda Campos-Martín; Arkaitz Carracedo; Elena García-Taboada; Manuel Guzmán; Sonia Hernández-Tiedra; Guillermo Velasco
Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death.
Autophagy 2011;7(9):1071-3.
2011: Arkaitz Carracedo; Keisuke Ito; Pier Paolo Pandolfi
The nuclear bodies inside out: PML conquers the cytoplasm.
Current opinion in cell biology 2011;23(3):360-6.
2011: Lydia W S Finley; Arkaitz Carracedo; Jaewon Lee; Amanda Souza; Ainara Egia; Jiangwen Zhang; Julie T Feldstein; Paula I Moreira; Sandra M Cardoso; Clary B Clish; Pier Paolo Pandolfi; Marcia C Haigis
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.
Cancer cell 2011;19(3):416-28.
2011: Arkaitz Carracedo; Andrea Alimonti; Pier Paolo Pandolfi
PTEN level in tumor suppression: how much is too little?
Cancer research 2011;71(3):629-33.
2011: Min Sup Song; Arkaitz Carracedo; Leonardo Salmena; Su Jung Song; Ainara Egia; Marcos Malumbres; Pier Paolo Pandolfi
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
Cell 2011;144(2):187-99.
2011: Atsuo Sasaki; Arkaitz Carracedo; Jason W Locasale; Dimitrios Anastasiou; Koh Takeuchi; Emily Rose Kahoud; Sasson Haviv; John M Asara; Pier Paolo Pandolfi; Lewis C Cantley
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Science signaling 2011;4(163):ra13.
2010: Andrea Alimonti; Arkaitz Carracedo; John G Clohessy; Lloyd C Trotman; Caterina Nardella; Ainara Egia; Leonardo Salmena; Katia Sampieri; William J Haveman; Edi Brogi; Andrea L Richardson; Jiangwen Zhang; Pier Paolo Pandolfi
Subtle variations in Pten dose determine cancer susceptibility.
Nature genetics 2010;42(5):454-8.
2010: Ekaitz Agirregoitia; Arkaitz Carracedo; Nerea Subiran; Asier Valdivia; Naiara Agirregoitia; Laura Peralta; Guillermo Velasco; Jon Irazusta
The CB(2) cannabinoid receptor regulates human sperm cell motility.
Fertility and sterility 2010;93(5):1378-87.
2010: Andrea Alimonti; Caterina Nardella; Zhenbang Chen; John G Clohessy; Arkaitz Carracedo; Lloyd C Trotman; Ke Cheng; Shohreh Varmeh; Sara C Kozma; George Thomas; Erika Rosivatz; Rudiger Woscholski; Francesco Cognetti; Howard I Scher; Pier Paolo Pandolfi
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
The Journal of clinical investigation 2010;120(3):681-93.
2010: Caterina Nardella; Arkaitz Carracedo; Leonardo Salmena; Pier Paolo Pandolfi
Faithfull modeling of PTEN loss driven diseases in the mouse.
Current topics in microbiology and immunology 2010;347():135-68.
2009: María Salazar; Arkaitz Carracedo; Iñigo J Salanueva; Sonia Hernández-Tiedra; Ainara Egia; Mar Lorente; Patricia Vázquez; Sofia Torres; Juan L Iovanna; Manuel Guzmán; Patricia Boya; Guillermo Velasco
TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action.
Autophagy 2009;5(7):1048-9.
2009: Mar Lorente; Arkaitz Carracedo; Sofía Torres; Francesco Natali; Ainara Egia; Sonia Hernández-Tiedra; María Salazar; Cristina Blázquez; Manuel Guzmán; Guillermo Velasco
Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.
Glia 2009;57(13):1374-85.
2009: Alejandro Gutierrez; Takaomi Sanda; Ruta Grebliunaite; Arkaitz Carracedo; Leonardo Salmena; Yebin Ahn; Suzanne Dahlberg; Donna Neuberg; Lisa A Moreau; Stuart S Winter; Richard Larson; Jianhua Zhang; Alexei Protopopov; Lynda Chin; Pier Paolo Pandolfi; Lewis B Silverman; Stephen P Hunger; Stephen E Sallan; A Thomas Look
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
Blood 2009;114(3):647-50.
2009: María Salazar; Arkaitz Carracedo; Iñigo J Salanueva; Sonia Hernández-Tiedra; Mar Lorente; Ainara Egia; Patricia Vázquez; Cristina Blázquez; Sofía Torres; Stephane García; Jonathan Nowak; Gian María Fimia; Mauro Piacentini; Francesco Cecconi; Pier Paolo Pandolfi; Luis González-Feria; Juan L Iovanna; Manuel Guzmán; Patricia Boya; Guillermo Velasco
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
The Journal of clinical investigation 2009;119(5):1359-72.
2009: Brett S Carver; Jennifer Tran; Anuradha Gopalan; Zhenbang Chen; Safa Shaikh; Arkaitz Carracedo; Andrea Alimonti; Caterina Nardella; Shohreh Varmeh; Peter T Scardino; Carlos Cordon-Cardo; William Gerald; Pier Paolo Pandolfi
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
Nature genetics 2009;41(5):619-24.
2009: Zhenbang Chen; Arkaitz Carracedo; Hui-Kuan Lin; Jason A Koutcher; Nille Behrendt; Ainara Egia; Andrea Alimonti; Brett S Carver; William Gerald; Julie T Feldstein; Massimo Loda; Pier Paolo Pandolfi
Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.
Science signaling 2009;2(84):ra44.
2009: Caterina Nardella; Arkaitz Carracedo; Andrea Alimonti; Robin M Hobbs; John G Clohessy; Zhenbang Chen; Ainara Egia; Alessandro Fornari; Michelangelo Fiorentino; Massimo Loda; Sara C Kozma; George Thomas; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Differential requirement of mTOR in postmitotic tissues and tumorigenesis.
Science signaling 2009;2(55):ra2.
2008: Arkaitz Carracedo; Jose Baselga; Pier Paolo Pandolfi
Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors.
Cell cycle (Georgetown, Tex.) 2008;7(24):3805-9.
2008: Min Sup Song; Leonardo Salmena; Arkaitz Carracedo; Ainara Egia; Francesco Lo Coco; Julie T Feldstein; Pier Paolo Pandolfi
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.
Nature 2008;455(7214):813-7.
2008: Arkaitz Carracedo; Pier Paolo Pandolfi
The PTEN-PI3K pathway: of feedbacks and cross-talks.
Oncogene 2008;27(41):5527-41.
2008: Arkaitz Carracedo; Li Ma; Julie T Feldstein; Federico Rojo; Leonardo Salmena; Andrea Alimonti; Ainara Egia; Atsuo Sasaki; George Thomas; Sara C Kozma; Antonella Papa; Caterina Nardella; Lewis C Cantley; Jose Baselga; Pier Paolo Pandolfi
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
The Journal of clinical investigation 2008;118(9):3065-74.
2008: Caterina Nardella; Zhenbang Chen; Leonardo Salmena; Arkaitz Carracedo; Andrea Alimonti; Ainara Egia; Brett S Carver; William Gerald; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
Genes & development 2008;22(16):2172-7.
2008: Kalpana K Reddy; Benjamin Lefkove; Lan Bo Chen; Baskaran Govindarajan; Arkaitz Carracedo; Guillermo Velasco; Carol O Carrillo; Sulochana S Bhandarkar; Michael J Owens; Fatima Mechta-Grigoriou; Jack L Arbiser
The antidepressant sertraline downregulates Akt and has activity against melanoma cells.
Pigment cell & melanoma research 2008;21(4):451-6.
2008: Arkaitz Carracedo; Leonardo Salmena; Pier Paolo Pandolfi
SnapShot: PTEN signaling pathways.
Cell 2008;133(3):550.e1.
2008: Leonardo Salmena; Arkaitz Carracedo; Pier Paolo Pandolfi
Tenets of PTEN tumor suppression.
Cell 2008;133(3):403-14.
2008: Cristina Blázquez; María Salazar; Arkaitz Carracedo; Mar Lorente; Ainara Egia; Luis González-Feria; Amador Haro; Guillermo Velasco; Manuel Guzmán
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
Cancer research 2008;68(6):1945-52.
2008: Cristina Blázquez; Arkaitz Carracedo; María Salazar; Mar Lorente; Ainara Egia; Luis González-Feria; Amador Haro; Guillermo Velasco; Manuel Guzmán
Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?
Neuropharmacology 2008;54(1):235-43.
2007: Guillermo Velasco; Arkaitz Carracedo; Cristina Blázquez; Mar Lorente; Tania Aguado; Amador Haro; Cristina Sánchez; Ismael Galve-Roperh; Manuel Guzmán
Cannabinoids and gliomas.
Molecular neurobiology 2007;36(1):60-7.
2007: Tania Aguado; Arkaitz Carracedo; Boris Julien; Guillermo Velasco; Garry Milman; Urij Rampampam; Luis Alvarez; Manuel Guzmán; Ismael Galve-Roperh
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis.
The Journal of biological chemistry 2007;282(9):6854-62.
2006: Cristina Blázquez; Arkaitz Carracedo; Lucía Barrado; Pedro José Real; José Luis Fernández-Luna; Guillermo Velasco; Marcos Malumbres; Manuel Guzmán
Cannabinoid receptors as novel targets for the treatment of melanoma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2633-5.
2006: Ekaitz Agirregoitia; Asier Valdivia; Arkaitz Carracedo; Luis Casis; Javier Gil; Nerea Subiran; Carmen Ochoa; Jon Irazusta
Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility.
The Journal of clinical endocrinology and metabolism 2006;91(12):4969-75.
2006: Arkaitz Carracedo; Meritxell Gironella; Mar Lorente; Stephane Garcia; Manuel Guzmán; Guillermo Velasco; Juan L Iovanna
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.
Cancer research 2006;66(13):6748-55.
2006: Blanca Herrera; Arkaitz Carracedo; María Diez-Zaera; Teresa Gómez del Pulgar; Manuel Guzmán; Guillermo Velasco
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway.
Experimental cell research 2006;312(11):2121-31.
2006: Arkaitz Carracedo; Mar Lorente; Ainara Egia; Cristina Blázquez; Stephane García; Valentin Giroux; Cedric Malicet; Raquel Villuendas; Meritxell Gironella; Luis González-Feria; Miguel Angel Piris; Juan L Iovanna; Manuel Guzmán; Guillermo Velasco
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.
Cancer cell 2006;9(4):301-12.
2006: Arkaitz Carracedo; Ainara Egia; Manuel Guzmán; Guillermo Velasco
p8 Upregulation sensitizes astrocytes to oxidative stress.
FEBS letters 2006;580(6):1571-5.
2005: Blanca Herrera; Arkaitz Carracedo; María Diez-Zaera; Manuel Guzmán; Guillermo Velasco
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells.
FEBS letters 2005;579(22):5084-8.
2004: Arkaitz Carracedo; Math J H Geelen; María Diez; Kentaro Hanada; Manuel Guzmán; Guillermo Velasco
Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids.
The Biochemical journal 2004;380(Pt 2):435-40.