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Xiaodong Cheng

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TOP 3
Haijun Chen; Xiaodong Cheng; Oleg G Chepurny; George G Holz; Fang C Mei; Tamara Tsalkova; Jia Zhou
Identification and characterization of small molecules as potent and specific EPAC2 antagonists.
Yun Jiang; Yu Ou; Xiaodong Cheng
Role of TSG101 in cancer.
Muayad Almahariq; Haijun Chen; Fang C Mei; Sarita K Sastry; Frank Schwede; Tamara Tsalkova; Jia Zhou; Xiaodong Cheng
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

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All Publications

2013: Haijun Chen; Xiaodong Cheng; Oleg G Chepurny; George G Holz; Fang C Mei; Tamara Tsalkova; Jia Zhou
Identification and characterization of small molecules as potent and specific EPAC2 antagonists.
Journal of medicinal chemistry 2013;56(3):952-62.
2013: Yun Jiang; Yu Ou; Xiaodong Cheng
Role of TSG101 in cancer.
Frontiers in bioscience : a journal and virtual library 2013;18():279-88.
2013: Muayad Almahariq; Haijun Chen; Fang C Mei; Sarita K Sastry; Frank Schwede; Tamara Tsalkova; Jia Zhou; Xiaodong Cheng
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
Molecular pharmacology 2013;83(1):122-8.
2012: Tamara Tsalkova; Virgil L Woods; Oleg G Chepurny; George G Holz; Colin A Leech; Sheng Li; Tong Liu; Fang C Mei; Xiaodong Cheng
Isoform-specific antagonists of exchange proteins directly activated by cAMP.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18613-8.
2012: Haijun Chen; Xiaodong Cheng; Yaohua Hu; Fang C Mei; Tamara Tsalkova; Jia Zhou
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.
Bioorganic & medicinal chemistry letters 2012;22(12):4038-43.
2012: Tamara Tsalkova; Fang C Mei; Xiaodong Cheng
A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists.
PloS one 2012;7(1):e30441.
2010: Zhenyu Ji; Fang C Mei; Xiaodong Cheng
Epac, not PKA catalytic subunit, is required for 3T3-L1 preadipocyte differentiation.
Frontiers in bioscience (Elite edition) 2010;2():392-8.
2009: Tamara Tsalkova; Donald K Blumenthal; Fang C Mei; Mark A White; Xiaodong Cheng
Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities.
The Journal of biological chemistry 2009;284(35):23644-51.
2009: Zhenyu Ji; Fang C Mei; Pedro L Lory; Scott R Gilbertson; Yijun Chen; Xiaodong Cheng
Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer.
Frontiers in bioscience : a journal and virtual library 2009;14():2904-10.
2008: Zhenyu Ji; Fang C Mei; Aaron L Miller; E Brad Thompson; Xiaodong Cheng
Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells.
The Journal of biological chemistry 2008;283(32):21920-5.
2008: Xiaodong Cheng; Zhenyu Ji; Tamara Tsalkova; Fang C Mei
Epac and PKA: a tale of two intracellular cAMP receptors.
Acta biochimica et biophysica Sinica 2008;40(7):651-62.
2008: Xiaodong Cheng
Silent assassin: oncogenic ras directs epigenetic inactivation of target genes.
Science signaling 2008;1(13):pe14.
2007: Zhenyu Ji; Fang C Mei; Betty H Johnson; E Brad Thompson; Xiaodong Cheng
Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells.
The Journal of biological chemistry 2007;282(52):37370-7.
2007: Melissa Brock; Fenghui Fan; Fang C Mei; Sheng Li; Chris R Gessner; Virgil L Woods; Xiaodong Cheng
Conformational analysis of Epac activation using amide hydrogen/deuterium exchange mass spectrometry.
The Journal of biological chemistry 2007;282(44):32256-63.
2007: Chad M Wayne; Heng-Yu Fan; Xiaodong Cheng; JoAnne S Richards
Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1940-57.
2007: Travis W Young; Daniel G Rosen; Fang C Mei; Nan Li; Jinsong Liu; Xiao-Fan Wang; Xiaodong Cheng
Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(13):3848-54.
2007: Zhenyu Ji; Fang C Mei; Jingwu Xie; Xiaodong Cheng
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.
The Journal of biological chemistry 2007;282(19):14048-55.
2007: Travis W Young; Fang C Mei; Daniel G Rosen; Gong Yang; Nan Li; Jinsong Liu; Xiaodong Cheng
Up-regulation of tumor susceptibility gene 101 protein in ovarian carcinomas revealed by proteomics analyses.
Molecular & cellular proteomics : MCP 2007;6(2):294-304.
2007: Xiaodong Cheng; Travis W Young; Fang C Mei
Proteomics analyses of ovarian cancer using genetically defined human ovarian cancer models.
Frontiers in bioscience : a journal and virtual library 2007;12():5166-74.
2007: Jing Li; Kathleen O'Connor; Xiaodong Cheng; Fang C Mei; Tatsuo Uchida; Courtney M Townsend; B Mark Evers
Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):159-71.
2006: Shaoning Yu; Fenghui Fan; Samuel C Flores; Fang Mei; Xiaodong Cheng
Dissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling.
Biochemistry 2006;45(51):15318-26.
2006: Fang C Mei; Travis W Young; Jinsong Liu; Xiaodong Cheng
RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):497-9.
2006: Reynolds K B Brobey; Fang C Mei; Xiaodong Cheng; Lynn Soong
Comparative two-dimensional gel electrophoresis maps for promastigotes of Leishmania amazonensis and Leishmania major.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2006;10(1):1-6.
2005: Fang C Mei; Xiaodong Cheng
Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton.
Molecular bioSystems 2005;1(4):325-31.
2005: Travis Young; Fang Mei; Jinsong Liu; Robert C Bast; Alexander Kurosky; Xiaodong Cheng
Proteomics analysis of H-RAS-mediated oncogenic transformation in a genetically defined human ovarian cancer model.
Oncogene 2005;24(40):6174-84.
2005: Liping Zhang; Ruwen Cui; Xiaodong Cheng; Jie Du
Antiapoptotic effect of serum and glucocorticoid-inducible protein kinase is mediated by novel mechanism activating I{kappa}B kinase.
Cancer research 2005;65(2):457-64.
2005: Xiaodong Cheng
Understanding signal transduction through functional proteomics.
Expert review of proteomics 2005;2(1):103-16.
2004: Lisa M DiPilato; Xiaodong Cheng; Jin Zhang
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16513-8.
2004: Travis W Young; Fang C Mei; Gong Yang; Jennifer A Thompson-Lanza; Jinsong Liu; Xiaodong Cheng
Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry.
Cancer research 2004;64(13):4577-84.
2004: Shaoning Yu; Fang C Mei; J Ching Lee; Xiaodong Cheng
Probing cAMP-dependent protein kinase holoenzyme complexes I alpha and II beta by FT-IR and chemical protein footprinting.
Biochemistry 2004;43(7):1908-20.
2002: Jianquan Li; Xiaodong Cheng; J Ching Lee
Structure and dynamics of the modular halves of Escherichia coli cyclic AMP receptor protein.
Biochemistry 2002;41(50):14771-8.
2002: James R Jabbur; Amy D Tabor; Xiaodong Cheng; Hua Wang; Motonari Uesugi; Guillermina Lozano; Wei Zhang
Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.
Oncogene 2002;21(46):7100-13.
2002: Jingbo Qiao; Fang C Mei; Vsevolod L Popov; Leoncio A Vergara; Xiaodong Cheng
Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.
The Journal of biological chemistry 2002;277(29):26581-6.
2002: Fang C Mei; Jingbo Qiao; Oxana M Tsygankova; Judy L Meinkoth; Lawrence A Quilliam; Xiaodong Cheng
Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.
The Journal of biological chemistry 2002;277(13):11497-504.
2001: Xiaodong Cheng; Christopher Phelps; Susan S Taylor
Differential binding of cAMP-dependent protein kinase regulatory subunit isoforms Ialpha and IIbeta to the catalytic subunit.
The Journal of biological chemistry 2001;276(6):4102-8.
1999: Milind Gangal; T Clifford; J Deich; Xiaodong Cheng; Susan S Taylor; David A Johnson
Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12394-9.
1999: Susan S Taylor; E Radzio-Andzelm; Xiaodong Cheng; Lynn F Ten Eyck; N Narayana
Catalytic subunit of cyclic AMP-dependent protein kinase: structure and dynamics of the active site cleft.
Pharmacology & therapeutics 1999;82(2-3):133-41.
1998: Xiaodong Cheng; S Shaltiel; Susan S Taylor
Mapping substrate-induced conformational changes in cAMP-dependent protein kinase by protein footprinting.
Biochemistry 1998;37(40):14005-13.
1998: Xiaodong Cheng; Y Ma; M Moore; B A Hemmings; Susan S Taylor
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9849-54.
1998: Xiaodong Cheng; J Ching Lee
Interactive and dominant effects of residues 128 and 141 on cyclic nucleotide and DNA bindings in Escherichia coli cAMP receptor protein.
The Journal of biological chemistry 1998;273(2):705-12.
1998: Xiaodong Cheng; J Ching Lee
Differential perturbation of intersubunit and interdomain communications by glycine 141 mutation in Escherichia coli CRP.
Biochemistry 1998;37(1):51-60.
1996: Xiaodong Cheng; RH Friesen; J Ching Lee
Effects of conserved residues on the regulation of rabbit muscle pyruvate kinase.
The Journal of biological chemistry 1996;271(11):6313-21.
1995: Xiaodong Cheng; L Kovac; J Ching Lee
Probing the mechanism of CRP activation by site-directed mutagenesis: the role of serine 128 in the allosteric pathway of cAMP receptor protein activation.
Biochemistry 1995;34(34):10816-26.
1994: Xiaodong Cheng; J Ching Lee
Absolute requirement of cyclic nucleotide in the activation of the G141Q mutant cAMP receptor protein from Escherichia coli.
The Journal of biological chemistry 1994;269(49):30781-4.
1993: Xiaodong Cheng; M L Gonzalez; J Ching Lee
Energetics of intersubunit and intrasubunit interactions of Escherichia coli adenosine cyclic 3',5'-phosphate receptor protein.
Biochemistry 1993;32(32):8130-9.
1991: X D Cheng; Xiaodong Cheng; J P Shi; Y L Wang
Arginyl-tRNA synthetase from Escherichia coli affinity labeling with 3'-oxidized tRNA(Arg).
Science in China. Series B, Chemistry, life sciences & earth sciences 1991;34(3):297-305.
1990: M Santer; E Bennett-Guerrero; S Byahatti; S Czarnecki; D O'Connell; M Meyer; J Khoury; Xiaodong Cheng; I Schwartz; J McLaughlin
Base changes at position 792 of Escherichia coli 16S rRNA affect assembly of 70S ribosomes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3700-4.
1988: Xiaodong Cheng; J P Shi; X D Cheng; Y L Wang
Arginyl-tRNA synthetase from Escherichia coli, purification by affinity chromatography, properties, and steady-state kinetics.
Biochemistry 1988;27(17):6343-8.