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Jane Trepel

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Soichiro Yoshida; Didier Picard; Carole Sourbier; Manabu Tatokoro; Jane Trepel; Shinji Tsutsumi; Evangelia Vartholomaiou; Wanping Xu; Kristin Beebe; Yang Chen; Hiroshi Fukushima; Hisashi Hasumi; Kazunori Kihara; Fumitaka Koga; Min-Jung Lee; Sunmin Lee; Naoto Miyajima; Robert P Mohney; Guillaume Muhlebach; Ken Nakamura; Len Neckers
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
Carole Sourbier; Jane Trepel; Thomas L Prince; Ranjala Ratnayake; Bradley T Scroggins; John A Beutler; Min-Jung Lee; Sunmin Lee; Young H Lee; W Marston Linehan; Peter Literati Nagy; Len Neckers
Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.
Stéphanie Solier; Jane Trepel; Wanping Xu; Kurt W Kohn; Leonard Neckers; Bradley Scroggins; Yves Pommier
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.

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All Publications

2013: Soichiro Yoshida; Didier Picard; Carole Sourbier; Manabu Tatokoro; Jane Trepel; Shinji Tsutsumi; Evangelia Vartholomaiou; Wanping Xu; Kristin Beebe; Yang Chen; Hiroshi Fukushima; Hisashi Hasumi; Kazunori Kihara; Fumitaka Koga; Min-Jung Lee; Sunmin Lee; Naoto Miyajima; Robert P Mohney; Guillaume Muhlebach; Ken Nakamura; Len Neckers
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):E1604-12.
2013: Carole Sourbier; Jane Trepel; Thomas L Prince; Ranjala Ratnayake; Bradley T Scroggins; John A Beutler; Min-Jung Lee; Sunmin Lee; Young H Lee; W Marston Linehan; Peter Literati Nagy; Len Neckers
Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.
Cancer cell 2013;23(2):228-37.
2012: Stéphanie Solier; Jane Trepel; Wanping Xu; Kurt W Kohn; Leonard Neckers; Bradley Scroggins; Yves Pommier
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(32):12866-72.
2011: Wing-Hang Tong; Jane Trepel; Sophie Vaulont; Benoit Viollet; Manish Vira; Youfeng Yang; Rachid Sougrat; Carole Sourbier; Ramaprasad Srinivasan; Gennady Bratslavsky; Manik Ghosh; Suh Young Jeong; Yeong Sang Kim; Gennady Kovtunovych; Sunmin Lee; W Marston Linehan; Vladimir Valera Romero; Tracey A Rouault
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Cancer cell 2011;20(3):315-27.
2011: Wanping Xu; Jane Trepel; Len Neckers
Ras, ROS and proteotoxic stress: a delicate balance.
Cancer cell 2011;20(3):281-2.
2011: Giuseppe Giaccone; Arun Rajan; Arlene Berman; Ronan J Kelly; Eva Szabo; Ariel Lopez-Chavez; Jane Trepel; Min-Jung Lee; Liang Cao; Igor Espinoza-Delgado; John Spittler; Patrick J Loehrer
Phase II study of belinostat in patients with recurrent or refractory advanced thymic epithelial tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(15):2052-9.
2011: Mehdi Mollapour; Jane Trepel; Shinji Tsutsumi; Yeong Sang Kim; Len Neckers
Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity.
Oncotarget 2011;2(5):407-17.
2011: Shivaani Kummar; Martin E Gutierrez; Alice Chen; Ismail B Turkbey; Deborah Allen; Yvonne R Horneffer; Lamin Juwara; Liang Cao; Yunkai Yu; Yeong Sang Kim; Jane Trepel; Helen Chen; Peter Choyke; Giovanni Melillo; Anthony J Murgo; Jerry Collins; James H Doroshow
Phase I trial of vandetanib and bevacizumab evaluating the VEGF and EGF signal transduction pathways in adults with solid tumours and lymphomas.
European journal of cancer (Oxford, England : 1990) 2011;47(7):997-1005.
2011: Mehdi Mollapour; Shinji Tsutsumi; Andrew Truman; Wanping Xu; Cara K Vaughan; Kristin Beebe; Anna Konstantinova; Srinivas Vourganti; Barry Panaretou; Peter W Piper; Jane Trepel; Chrisostomos Prodromou; Laurence H Pearl; Len Neckers
Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity.
Molecular cell 2011;41(6):672-81.
2010: Hye Sik Kong; Sunmin Lee; Kristin Beebe; Bradley Scroggins; Gopal Gupta; Min-Jung Lee; Yun-Jin Jung; Jane Trepel; Len Neckers
Emetine promotes von Hippel-Lindau-independent degradation of hypoxia-inducible factor-2α in clear cell renal carcinoma.
Molecular pharmacology 2010;78(6):1072-8.
2010: Jane Trepel; Mehdi Mollapour; Giuseppe Giaccone; Len Neckers
Targeting the dynamic HSP90 complex in cancer.
Nature reviews. Cancer 2010;10(8):537-49.
2010: Yang-Min Ning; James L Gulley; Philip M Arlen; Sukyung Woo; Seth M Steinberg; John J Wright; Howard L Parnes; Jane Trepel; Min-Jung Lee; Yeong Sang Kim; Haihao Sun; Ravi A Madan; Lea Latham; Elizabeth Jones; Clara C Chen; William D Figg; William L Dahut
Phase II trial of bevacizumab, thalidomide, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(12):2070-6.
2010: Mehdi Mollapour; Shinji Tsutsumi; Alison C Donnelly; Kristin Beebe; Mari J Tokita; Min-Jung Lee; Sunmin Lee; Giulia Morra; Dimitra Bourboulia; Bradley T Scroggins; Giorgio Colombo; Brian S Blagg; Barry Panaretou; William Stetler-Stevenson; Jane Trepel; Peter W Piper; Chrisostomos Prodromou; Laurence H Pearl; Len Neckers
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.
Molecular cell 2010;37(3):333-43.
2009: Shinji Tsutsumi; Mehdi Mollapour; Christian Graf; Chung-Tien Lee; Bradley T Scroggins; Wanping Xu; Lenka Haslerova; Martin Hessling; Anna A Konstantinova; Jane Trepel; Barry Panaretou; Johannes Buchner; Matthias P Mayer; Chrisostomos Prodromou; Len Neckers
Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain.
Nature structural & molecular biology 2009;16(11):1141-7.
2009: Sunil Sudarshan; Carole Sourbier; Hye Sik Kong; Karen Block; Vladimir A Valera Romero; Youfeng Yang; Cynthia Galindo; Mehdi Mollapour; Bradley Scroggins; Norman Goode; Min-Jung Lee; Campbell W Gourlay; Jane Trepel; W Marston Linehan; Len Neckers
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.
Molecular and cellular biology 2009;29(15):4080-90.
2009: J Frederic Mushinski; Phuongmai Nguyen; Lisa M Stevens; Chand Khanna; Sunmin Lee; Eun Joo Chung; Min-Jung Lee; Yeong Sang Kim; W Marston Linehan; Michel A Horisberger; Jane Trepel
Inhibition of tumor cell motility by the interferon-inducible GTPase MxA.
The Journal of biological chemistry 2009;284(22):15206-14.
2009: Cynthia A Pise-Masison; Michael F Radonovich; Kathleen Dohoney; John C Morris; Deirdre O'Mahony; Min-Jung Lee; Jane Trepel; Thomas Waldmann; John E Janik; John N Brady
Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability.
Blood 2009;113(17):4016-26.
2009: Yeong Sang Kim; S V Alarcon; S Lee; Mao-Jung Lee; Giuseppe Giaccone; Len Neckers; Jane Trepel
Update on Hsp90 inhibitors in clinical trial.
Current topics in medicinal chemistry 2009;9(15):1479-92.
2008: Min-Jung Lee; Yeong Sang Kim; Shivaani Kummar; Giuseppe Giaccone; Jane Trepel
Histone deacetylase inhibitors in cancer therapy.
Current opinion in oncology 2008;20(6):639-49.
2008: Akihiro Yano; Shinji Tsutsumi; Shiro Soga; Min-Jung Lee; Jane Trepel; Hiroyuki Osada; Len Neckers
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15541-6.
2008: Xu-Hui Zhang; Mahadev Rao; Joseph A Loprieato; Julie A Hong; Ming Zhao; Guo-Zhu Chen; Ashley E Humphries; Dao Nguyen; Jane Trepel; Xiaodan Yu; David S Schrump
Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.
Cancer biology & therapy 2008;7(9):1388-97.
2008: Tsoching Chen; Min-Jung Lee; Yeong Sang Kim; Sunmin Lee; Shivaani Kummar; Martin Gutierrez; Stephen M Hewitt; Jane Trepel; Ira Levin
Pharmacodynamic assessment of histone deacetylase inhibitors: infrared vibrational spectroscopic imaging of protein acetylation.
Analytical chemistry 2008;80(16):6390-6.
2008: Tomohiro Kajiguchi; Sunmin Lee; Min-Jung Lee; Jane Trepel; Len Neckers
KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia.
Leukemia research 2008;32(5):761-70.
2008: Lunching Sun; Lei Huang; Phuongmai Nguyen; Kheem S Bisht; Gil Bar-Sela; Allen S Ho; C Matthew Bradbury; Wenqiang Yu; Hengmi Cui; Sunmin Lee; Jane Trepel; Andrew P Feinberg; David Gius
DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.
Cancer research 2008;68(8):2726-35.
2008: Shinji Tsutsumi; B Scroggins; F Koga; Mao-Jung Lee; Jane Trepel; Sara J Felts; C Carreras; Len Neckers
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion.
Oncogene 2008;27(17):2478-87.
2008: Jacopo Mariotti; Jason Foley; Unsu Jung; Todd Borenstein; Nermina Kantardzic; Soo Han; Joshua T Hanson; Elaine Wong; Nicole Buxhoeveden; Jane Trepel; Antonio Tito Fojo; William G Telford; Daniel H Fowler
Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):89-105.
2007: Tomohiro Kajiguchi; Eun Joo Chung; Sunmin Lee; A Stine; Hitoshi Kiyoi; Tomoki Naoe; Mark Levis; Len Neckers; Jane Trepel
FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
Leukemia 2007;21(12):2476-84.
2007: Wanping Xu; Shiro Soga; Kristin Beebe; M-J Lee; Yeong Sang Kim; Jane Trepel; Len Neckers
Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition.
British journal of cancer 2007;97(6):741-4.
2007: Shivaani Kummar; Martin Gutierrez; Erin R Gardner; Erin Donovan; Kyunghwa Hwang; Eun Joo Chung; Min-Jung Lee; Kim Maynard; Mikhail Kalnitskiy; Alice Chen; Giovanni Melillo; Qin C Ryan; BA Conley; William D Figg; Jane Trepel; James Zwiebel; James Doroshow; Anthony J Murgo
Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 1):5411-7.
2007: Alessio Giubellino; Yang Gao; Sunmin Lee; Min-Jung Lee; James R Vasselli; Sampath Medepalli; Jane Trepel; Terrence R Burke; Donald Bottaro
Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.
Cancer research 2007;67(13):6012-6.
2007: Ivana Gojo; Anchalee Jiemjit; Jane Trepel; Alex Sparreboom; William D Figg; Sandra Rollins; Michael L Tidwell; Jacqueline Greer; Eun Joo Chung; Min-Jung Lee; Steven D Gore; Edward A Sausville; James Zwiebel; Judith E Karp
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias.
Blood 2007;109(7):2781-90.
2006: Jay H Chang; Deepika Vuppalanchi; Erna A van Niekerk; Jane Trepel; N Carolyn Schanen; Jeffery L Twiss
PC12 cells regulate inducible cyclic AMP (cAMP) element repressor expression to differentially control cAMP response element-dependent transcription in response to nerve growth factor and cAMP.
Journal of neurochemistry 2006;99(6):1517-30.
2006: Andrea Niedermeier; Nickolai Talanin; Eun Joo Chung; Ryan E Sells; Debra L Borris; Jan M Orenstein; Jane Trepel; Andrew Blauvelt
Histone deacetylase inhibitors induce apoptosis with minimal viral reactivation in cells infected with Kaposi's sarcoma-associated herpesvirus.
The Journal of investigative dermatology 2006;126(11):2516-24.
2006: Gagani Athauda; Alessio Giubellino; Jonathan Coleman; Christine E Horak; Patricia S Steeg; Ming-Jung Lee; Jane Trepel; Jennifer Wimberly; Jan Sun; Angela Coxon; Teresa L Burgess; Donald Bottaro
c-Met ectodomain shedding rate correlates with malignant potential.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4154-62.
2006: Eun Joo Chung; Min-Jung Lee; Sunmin Lee; Jane Trepel
Assays for pharmacodynamic analysis of histone deacetylase inhibitors.
Expert opinion on drug metabolism & toxicology 2006;2(2):213-30.
2006: Monica G Marcu; Yun-Jin Jung; Sunmin Lee; Eun Joo Chung; Min-Jung Lee; Jane Trepel; Len Neckers
Curcumin is an inhibitor of p300 histone acetylatransferase.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2006;2(2):169-74.
2005: Yaffa R Rubinstein; Takashi Furusawa; Jae-Hwan Lim; Yuri V Postnikov; Katherine L West; Yehudit Birger; Sunmin Lee; Phuongmai Nguyen; Jane Trepel; Michael Bustin
Chromosomal protein HMGN1 modulates the expression of N-cadherin.
The FEBS journal 2005;272(22):5853-63.
2005: Edwin M Posadas; James L Gulley; Philip M Arlen; Alisa Trout; Howard L Parnes; John Wright; Min-Jung Lee; Eun Joo Chung; Jane Trepel; Alex Sparreboom; Clara Chen; Elizabeth Jones; Seth M Steinberg; Andrew Daniels; William D Figg; William L Dahut
A phase II study of perifosine in androgen independent prostate cancer.
Cancer biology & therapy 2005;4(10):1133-7.
2005: Jennifer S. Isaacs; Yun Jin Jung; David R Mole; Sunmin Lee; Carlos Torres-Cabala; Yuen-Li Chung; Maria Merino; Jane Trepel; Berton Zbar; Jorge Toro; Peter J Ratcliffe; W Marston Linehan; Len Neckers
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.
Cancer cell 2005;8(2):143-53.
2005: Qin C Ryan; Donna Headlee; Milin R Acharya; Alex Sparreboom; Jane Trepel; Joseph Ye; William D Figg; Kyunghwa Hwang; Eun Joo Chung; Anthony J Murgo; Giovanni Melillo; Yusri Elsayed; Manish Monga; Mikhail Kalnitskiy; James Zwiebel; Edward A Sausville
Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(17):3912-22.
2005: Federico A Steiner; Julie A Hong; Maria R Fischette; David G Beer; Z Sheng Guo; G Aaron Chen; Todd S Weiser; Edmund S Kassis; Dao Nguyen; Sunmin Lee; Jane Trepel; David S Schrump
Sequential 5-Aza 2'-deoxycytidine/depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2 (TFPI-2) expression in cancer cells.
Oncogene 2005;24(14):2386-97.
2005: Eun Joo Chung; Sunmin Lee; Edward A Sausville; Qin C Ryan; Judith E Karp; Ivana Gojo; William G Telford; Min-Jung Lee; Hye Sik Kong; Jane Trepel
Histone deacetylase inhibitor pharmacodynamic analysis by multiparameter flow cytometry.
Annals of clinical and laboratory science 2005;35(4):397-406.
2004: Mona S Jhaveri; Antonina Rait; Koong-Nah Chung; Jane Trepel; Esther H Chang
Antisense oligonucleotides targeted to the human alpha folate receptor inhibit breast cancer cell growth and sensitize the cells to doxorubicin treatment.
Molecular cancer therapeutics 2004;3(12):1505-12.
2004: Ronald G Polzin; Houda Benlhabib; Jane Trepel; Julio E Herrera
E2F sites in the Op18 promoter are required for high level of expression in the human prostate carcinoma cell line PC-3-M.
Gene 2004;341():209-18.
2004: Andrea I Loaiza-Pérez; Susan Kenney; Jamie L Boswell; Melinda G Hollingshead; Michael C Alley; Curtis Hose; Henry P Ciolino; Grace Chao Yeh; Jane Trepel; David T Vistica; Edward A Sausville
Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells.
Molecular cancer therapeutics 2004;3(6):715-25.
2004: Dao Nguyen; William D Schrump; G Aaron Chen; Wilson Tsai; Phuongmai Nguyen; Jane Trepel; David S Schrump
Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1813-25.
2004: Kevin A Camphausen; William E Burgan; Michael A Cerra; Kelli A Oswald; Jane Trepel; Min-Jung Lee; Philip J Tofilon
Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.
Cancer research 2004;64(1):316-21.
2003: Jane Trepel
Ion channels as molecular targets in prostate cancer.
Clinical prostate cancer 2003;2(3):188-9.
2003: Wanping Xu; Xitong Yuan; Yun Jin Jung; Yongping Yang; Andrea Basso; Neal Rosen; Eun Joo Chung; Jane Trepel; Len Neckers
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.
Cancer research 2003;63(22):7777-84.
2003: Yun-Jin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Len Neckers
IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2115-7.
2003: Jane Trepel; Michael J Birrer
A link between histone deacetylase inhibitors and NF- kappaB signaling.
Cell cycle (Georgetown, Tex.) 2003;2(5):452-3.
2003: Hans-Joachim Ochel; Günther Gademann; Jane Trepel; L Neckers
Modulation of prion protein structural integrity by geldanamycin.
Glycobiology 2003;13(9):655-60.
2003: Martin J Edelman; Kenneth S. Bauer; Shyam Khanwani; Nancy Tait; Jane Trepel; Judith E Karp; Noble Nemieboka; Eun Joo Chung; David A Van Echo
Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug.
Cancer chemotherapy and pharmacology 2003;51(5):439-44.
2003: YunJin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Zheng-Gang Liu; Len Neckers
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation.
The Biochemical journal 2003;370(Pt 3):1011-7.
2003: Masa-Aki Shibata; Claudine Kavanaugh; Eiko Shibata; Hideaki Abe; Phuongmai Nguyen; Yoshinori Otsuki; Jane Trepel; Jeffrey E Green
Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models.
Carcinogenesis 2003;24(3):453-9.
2003: Yun-Jin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Len Neckers
Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein.
The Journal of biological chemistry 2003;278(9):7445-52.
2003: Valentina Trapani; Vyomesh Patel; Chee-Onn Leong; Henry P Ciolino; Grace Chao Yeh; Curtis Hose; Jane Trepel; Malcolm F G Stevens; Edward A Sausville; Andrea I Loaiza-Pérez
DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells.
British journal of cancer 2003;88(4):599-605.
2002: Sang-Gu Hwang; Hyung Chul Lee; Jane Trepel; Byung Hun Jeon
Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin.
Leukemia research 2002;26(9):863-71.
2002: Eun Joo Chung; Sang-Gu Hwang; Phuongmai Nguyen; Sunmin Lee; Jung-Sik Kim; Jin Woo Kim; Pierre A Henkart; Donald Bottaro; Lilian Soon; Paolo Bonvini; Su-Jun Lee; Judith E Karp; Ho Jung Oh; Jeffrey S Rubin; Jane Trepel
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin.
Blood 2002;100(3):982-90.
2002: Ramon G Manzano; Luis M Montuenga; Mark Dayton; Paul Dent; Ichiro Kinoshita; Silvestre Vicent; Ginger J Gardner; Phuongmai Nguyen; Yung Hyun Choi; Jane Trepel; Nelly Auersperg; Michael J Birrer
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.
Oncogene 2002;21(28):4435-47.
2002: Seok Hee Park; Sae Ra Lee; Byung-Chul Kim; Eun Ah Cho; Sejal P Patel; Hee-Bum Kang; Edward A Sausville; Osamu Nakanishi; Jane Trepel; Byoung-Ick Lee; Seong-Jin Kim
Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells.
The Journal of biological chemistry 2002;277(7):5168-74.
2002: Wanping Xu; Edward G Mimnaugh; Jung-Sik Kim; Jane Trepel; Leonard M Neckers
Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2.
Cell stress & chaperones 2002;7(1):91-6.
2002: Andrea I Loaiza-Pérez; Valentina Trapani; Curtis Hose; Sheo S Singh; Jane Trepel; Malcolm F G Stevens; Tracey D Bradshaw; Edward A Sausville
Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole.
Molecular pharmacology 2002;61(1):13-9.
2001: Edward G Mimnaugh; Ganesh L Kayastha; N B McGovern; Sang-Gu Hwang; Monica G Marcu; Jane Trepel; Shi-Ying Cai; Vincent T Marchesi; Len Neckers
Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli.
Cell death and differentiation 2001;8(12):1182-96.
2001: M S Jhaveri; C Wagner; Jane Trepel
Impact of extracellular folate levels on global gene expression.
Molecular pharmacology 2001;60(6):1288-95.
2001: Spyro Mousses; Urs Wagner; Yidong Chen; J W Kim; Lukas Bubendorf; Michael Bittner; T Pretlow; Abdel G Elkahloun; Jane Trepel; Olli Kallioniemi
Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling.
Oncogene 2001;20(46):6718-23.
2001: M V Blagosklonny; T Fojo; Kapil N Bhalla; J S Kim; Jane Trepel; W D Figg; Y Rivera; Leonard M Neckers
The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy.
Leukemia 2001;15(10):1537-43.
2001: Ingalill Avis; SH Hong; A Martinez; Terry W Moody; Y H Choi; Jane Trepel; R Das; M Jett; James L Mulshine
Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):2007-9.
2001: Chand Khanna; Javed Khan; P Nguyen; J Prehn; Jana Caylor; Choh Yeung; Jane Trepel; Paul Meltzer; Lee Helman
Metastasis-associated differences in gene expression in a murine model of osteosarcoma.
Cancer research 2001;61(9):3750-9.
2001: Joong Su Kim; S Lee; T Lee; Y W Lee; Jane Trepel
Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor.
Biochemical and biophysical research communications 2001;281(4):866-71.
2001: Paolo Bonvini; Won G An; Angelo Rosolen; Phuongmai Nguyen; Jane Trepel; A Garcia de Herreros; M Dunach; Leonard M Neckers
Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription.
Cancer research 2001;61(4):1671-7.
2001: Byoung-Ick Lee; Seok Hee Park; J W Kim; Edward A Sausville; Heung Tae Kim; O Nakanishi; Jane Trepel; Seong-Jin Kim
MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells.
Cancer research 2001;61(3):931-4.
2000: Joong Su Kim; F Pirnia; Young Hun Choi; P M Nguyen; B Knepper; Maria Tsokos; TW Schulte; Michael J Birrer; Mikhail V Blagosklonny; O Schaefer; J Frederic Mushinski; Jane Trepel
Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint.
Oncogene 2000;19(52):6082-90.
2000: Edward G Mimnaugh; Manasses K Yunmbam; Qingdi Q Li; Paolo Bonvini; Sang-Gu Hwang; Jane Trepel; Eddie Reed; Len Neckers
Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors.
Biochemical pharmacology 2000;60(9):1343-54.
2000: Won G An; Sang-Gu Hwang; Jane Trepel; Mikhail V Blagosklonny
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
Leukemia 2000;14(7):1276-83.
2000: Mercedes Garayoa; Alfredo Martínez; Sunmin Lee; Rubén Pío; Won G An; Len Neckers; Jane Trepel; Luis M Montuenga; H Ryan; R Johnson; M Gassmann; Frank Cuttitta
Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.
Molecular endocrinology (Baltimore, Md.) 2000;14(6):848-62.
2000: Paolo Bonvini; S G Hwang; M El-Gamil; P Robbins; J S Kim; Jane Trepel; Len Neckers
Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells.
Biochimica et biophysica acta 2000;1495(3):308-18.
2000: Sara J Felts; Barbara A L Owen; P Nguyen; Jane Trepel; D B Donner; David O Toft
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.
The Journal of biological chemistry 2000;275(5):3305-12.
1999: Mikhail V Blagosklonny; Won G An; Giovanni Melillo; Phuongmai Nguyen; Jane Trepel; Leonard M Neckers
Regulation of BRCA1 by protein degradation.
Oncogene 1999;18(47):6460-8.
1999: Larisa Y Romanova; I A Alexandrov; Mikhail V Blagosklonny; R P Nordan; Susan H Garfield; Peter Acs; P Nguyen; Jane Trepel; Peter M Blumberg; J Frederic Mushinski
Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1.
Journal of cellular physiology 1999;179(2):157-69.
1999: Jeongwu Lee; Young Hun Choi; P Nguyen; J S Kim; Su-Jun Lee; Jane Trepel
Cyclic AMP induces inhibition of cyclin A expression and growth arrest in human hepatoma cells.
Biochimica et biophysica acta 1999;1449(3):261-8.
1999: J S Jang; Su-Jun Lee; Young Hun Choi; P M Nguyen; Jeewoo Lee; Sang-Gu Hwang; ML Wu; E Takano; M Maki; Pierre A Henkart; Jane Trepel
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease.
Oncogene 1999;18(10):1789-96.
1999: Paolo Bonvini; S G Hwang; M El-Gamil; P Robbins; Len Neckers; Jane Trepel
Melanoma cell lines contain a proteasome-sensitive, nuclear cytoskeleton-associated pool of beta-catenin.
Annals of the New York Academy of Sciences 1999;886():208-11.
1999: Hans-Joachim Ochel; TW Schulte; P Nguyen; Jane Trepel; L Neckers
The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase.
Molecular genetics and metabolism 1999;66(1):24-30.
1998: Min Kim; Yu Katayose; Qingdi Q Li; AN Rakkar; Zhuqing Li; Sang-Gu Hwang; D Katayose; Jane Trepel; Kenneth H Cowan; Pankaj Seth
Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1.
Biochemical and biophysical research communications 1998;253(3):672-7.
1998: C Rohlff; M V Blagosklonny; E Kyle; A Kesari; I Y Kim; D J Zelner; Frances T Hakim; Jane Trepel; Raymond C Bergan
Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21(waf1/cip1).
The Prostate 1998;37(1):51-9.
1998: H K Yang; F M Scott; Jane Trepel; J F Battey; Bruce E Johnson; Michael J Kelley
Correlation of expression of bombesin-like peptides and receptors with growth inhibition by an anti-bombesin antibody in small-cell lung cancer cell lines.
Lung cancer (Amsterdam, Netherlands) 1998;21(3):165-75.
1998: Mikhail V Blagosklonny; Won G An; Larisa Y Romanova; Jane Trepel; Tito Fojo; Len Neckers
p53 inhibits hypoxia-inducible factor-stimulated transcription.
The Journal of biological chemistry 1998;273(20):11995-8.
1998: Su-Jun Lee; M J Ha; Jeewoo Lee; Phuongmai Nguyen; Young Hun Choi; F Pirnia; W K Kang; X F Wang; Seong-Jin Kim; Jane Trepel
Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.
The Journal of biological chemistry 1998;273(17):10618-23.
1998: Paolo Bonvini; Phuongmai Nguyen; Jane Trepel; Leonard M Neckers
In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome.
Oncogene 1998;16(9):1131-9.
1997: Young Hun Choi; Su-Jun Lee; Phuongmai Nguyen; J S Jang; Jeewoo Lee; ML Wu; E Takano; M Maki; Pierre A Henkart; Jane Trepel
Regulation of cyclin D1 by calpain protease.
The Journal of biological chemistry 1997;272(45):28479-84.
1997: Clifford L Craig; R Wersto; Min Kim; E Ohri; Zhuqing Li; D Katayose; Su-Jun Lee; Jane Trepel; Kenneth H Cowan; Pankaj Seth
A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells.
Oncogene 1997;14(19):2283-9.
1996: TW Schulte; Mikhail V Blagosklonny; L Romanova; J Frederic Mushinski; Brett P Monia; JF Johnston; Phuongmai Nguyen; Jane Trepel; Leonard M Neckers
Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.
Molecular and cellular biology 1996;16(10):5839-45.
1996: Raymond C Bergan; E Kyle; Phuongmai Nguyen; Jane Trepel; C Ingui; Len Neckers
Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1-integrin.
Clinical & experimental metastasis 1996;14(4):389-98.
1996: Mikhail V Blagosklonny; TW Schulte; Phuongmai Nguyen; Jane Trepel; Leonard M Neckers
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.
Cancer research 1996;56(8):1851-4.
1996: A Thibault; D Samid; AC Tompkins; William D Figg; MR Cooper; R J Hohl; Jane Trepel; B Liang; N Patronas; D J Venzon; Eddie Reed; Charles E Myers
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):483-91.
1996: C Chavany; Edward G Mimnaugh; P Miller; R Bitton; Phuongmai Nguyen; Jane Trepel; Luke Whitesell; R Schnur; J Moyer; Len Neckers
p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.
The Journal of biological chemistry 1996;271(9):4974-7.
1995: Mikhail V Blagosklonny; TW Schulte; Phuongmai Nguyen; Edward G Mimnaugh; Jane Trepel; Len Neckers
Taxol induction of p21WAF1 and p53 requires c-raf-1.
Cancer research 1995;55(20):4623-6.
1995: Koong-Nah Chung; S Roberts; C H Kim; M Kirassova; Jane Trepel; P C Elwood
Rapid turnover and impaired cell-surface expression of the human folate receptor in mouse L(tk-) fibroblasts, a cell line defective in glycosylphosphatidylinositol tail synthesis.
Archives of biochemistry and biophysics 1995;322(1):228-34.
1995: M M Borner; Charles E Myers; Oliver Sartor; Yoshitatsu Sei; T Toko; Jane Trepel; E Schneider
Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.
Cancer research 1995;55(10):2122-8.
1995: P Leif Bergsagel; Leslie A Brents; Jane Trepel; W Michael Kuehl
Genes expressed selectively in murine and human plasma cell neoplasms.
Current topics in microbiology and immunology 1995;194():57-61.
1994: Koong-Nah Chung; T H Paik; S Roberts; C H Kim; M Kirassova; J N Weinstein; Jane Trepel; P C Elwood
Site-directed mutagenesis of tryptophan residues to conserved hydrophobic residues inhibits the processing of human KB cell folate receptor.
Archives of biochemistry and biophysics 1994;315(2):407-14.
1994: Jean L Grem; P Daychild; J Drake; F Geoffroy; Jane Trepel; F Pirnia; Carmen J Allegra
Cytotoxicity and metabolism of 4-methoxy-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine in HCT 116 colon cancer cells.
Biochemical pharmacology 1994;48(11):2117-26.
1994: M M Borner; E Schneider; F Pirnia; Oliver Sartor; Jane Trepel; Charles E Myers
The detergent Triton X-100 induces a death pattern in human carcinoma cell lines that resembles cytotoxic lymphocyte-induced apoptosis.
FEBS letters 1994;353(2):129-32.
1994: N Ben-Baruch; William C Reinhold; N Alexandrova; I Ichinose; M Blake; Jane Trepel; Maria Zajac-Kaye
c-myc Down-regulation in suramin-treated HL60 cells precedes growth inhibition but does not trigger differentiation.
Molecular pharmacology 1994;46(1):73-8.
1994: Yung-Jue Bang; F Pirnia; W G Fang; W K Kang; Oliver Sartor; Luke Whitesell; M J Ha; Maria Tsokos; M D Sheahan; Phuongmai Nguyen; W T Niklinski; Charles E Myers; Jane Trepel
Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5330-4.
1994: J M Gudas; M Oka; F Diella; Jane Trepel; Kenneth H Cowan
Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(3):295-304.
1993: F Fang; S Ahmad; J Lei; R W Klecker; Jane Trepel; T E Smithgall; Robert I Glazer
Effect of the mutation of tyrosine 713 in p93c-fes on its catalytic activity and ability to promote myeloid differentiation in K562 cells.
Biochemistry 1993;32(27):6995-7001.
1993: C Myers; Jane Trepel; Oliver Sartor; M Cooper; M Ranson; T Toko; M W Linehan
Antigrowth factor strategies.
Cancer 1993;71(3 Suppl):1172-8.
1993: daniel schlaifer; MR Cooper; M Attal; A O Sartor; Jane Trepel; G Laurent; Charles E Myers
Myeloperoxidase: an enzyme involved in intrinsic vincristine resistance in human myeloblastic leukemia.
Blood 1993;81(2):482-9.
1992: S Ahmad; Jane Trepel; S Ohno; K Suzuki; T Tsuruo; Robert I Glazer
Role of protein kinase C in the modulation of multidrug resistance: expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin.
Molecular pharmacology 1992;42(6):1004-9.
1992: Patrick G Johnston; J C Drake; Jane Trepel; Carmen J Allegra
Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.
Cancer research 1992;52(16):4306-12.
1992: C E Herzog; Jane Trepel; Lyn A Mickley; Susan E Bates; Antonio Tito Fojo
Various methods of analysis of mdr-1/P-glycoprotein in human colon cancer cell lines.
Journal of the National Cancer Institute 1992;84(9):711-6.
1992: Yung-Jue Bang; Seong-Jin Kim; David Danielpour; M A O'Reilly; K Y Kim; Charles E Myers; Jane Trepel
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3556-60.
1992: L K Yee; Carmen J Allegra; Jane Trepel; Jean L Grem
Metabolism and RNA incorporation of cyclopentenyl cytosine in human colorectal cancer cells.
Biochemical pharmacology 1992;43(7):1587-99.
1992: P Leif Bergsagel; C Victor-Kobrin; C R Timblin; Jane Trepel; W Michael Kuehl
A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(2):590-6.
1992: W G Fang; F Pirnia; Yung-Jue Bang; Charles E Myers; Jane Trepel
P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells.
The Journal of clinical investigation 1992;89(1):191-6.
1991: G Yu; S Ahmad; A Aquino; C R Fairchild; Jane Trepel; S Ohno; K Suzuki; T Tsuruo; Kenneth H Cowan; R I Glazer
Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein.
Cancer communications 1991;3(6):181-9.
1991: K H Dixon; Jane Trepel; S C Eng; Kenneth H Cowan
Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.
Cancer communications 1991;3(12):357-65.
1990: Y Sharoni; J Viallet; Jane Trepel; Edward A Sausville
Effect of guanine and adenine nucleotides on bombesin-stimulated phospholipase C activity in membranes from Swiss 3T3 and small cell lung carcinoma cells.
Cancer research 1990;50(17):5257-62.
1990: J G Park; H Frucht; R V LaRocca; D P Bliss; Y Kurita; T R Chen; J G Henslee; Jane Trepel; R T Jensen; Bruce E Johnson
Characteristics of cell lines established from human gastric carcinoma.
Cancer research 1990;50(9):2773-80.
1990: Edward A Sausville; Jane Trepel; J D Moyer
Inhibitors of bombesin-stimulated intracellular signals: interruption of an autocrine pathway as a therapeutic strategy in small cell lung carcinoma.
Progress in clinical and biological research 1990;354A():193-207.
1990: S J Graham; B Duval-Arnould; T C Mercado; Jane Trepel; J D Cotelingam
Burkitt's lymphoma: a pericardial presentation.
Cytopathology : official journal of the British Society for Clinical Cytology 1990;1(4):239-42.
1989: Angelo Rosolen; M Nakanishi; David G Poplack; D Cole; R Quinones; G Reaman; Jane Trepel; J D Cotelingam; Edward A Sausville; Gerald E Marti
Expression of interleukin-2 receptor beta subunit in hematopoietic malignancies.
Blood 1989;73(7):1968-72.
1989: J L Mulshine; R B Natale; Ingalill Avis; AM Treston; P G Kasprzyk; Y Nakanishi; Edward A Sausville; Jane Trepel; F Cuttitta
Autocrine growth factors and lung cancer.
Cancer treatment and research 1989;45():107-22.
1988: Jane Trepel; J D Moyer; F Cuttitta; H Frucht; D H Coy; R B Natale; James L Mulshine; R T Jensen; Edward A Sausville
A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line.
Biochemical and biophysical research communications 1988;156(3):1383-9.
1988: Jane Trepel; J D Moyer; R Heikkila; Edward A Sausville
Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line.
The Biochemical journal 1988;255(2):403-10.
1988: C Vidal; S Matsushita; Oscar R Colamonici; Jane Trepel; Hiroaki Mitsuya; Leonard M Neckers
Human T lymphotropic virus I infection deregulates surface expression of the transferrin receptor.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):984-8.
1988: Oscar R Colamonici; R Quinones; Angelo Rosolen; Jane Trepel; Edward A Sausville; J C Phares; Ronald E Gress; David G Poplack; J Weber; G P Schechter
The beta subunit of the interleukin-2 receptor mediates interleukin-2 induction of anti-CD3 redirected cytotoxic capability in large granular lymphocytes.
Blood 1988;71(3):825-8.
1988: J D Minna; F Cuttitta; J F Battey; J L Mulshine; I Linnoila; A F Gazdar; Jane Trepel; Edward A Sausville
Gastrin-releasing peptide and other autocrine growth factors in lung cancer: pathogenetic and treatment implications.
Important advances in oncology 1988;():55-64.
1988: Edward A Sausville; J D Moyer; R Heikkila; Leonard M Neckers; Jane Trepel
A correlation of bombesin-responsiveness with myc-family gene expression in small cell lung carcinoma cell lines.
Annals of the New York Academy of Sciences 1988;547():310-21.
1987: R Heikkila; Jane Trepel; Frank Cuttitta; Leonard M Neckers; Edward A Sausville
Bombesin-related peptides induce calcium mobilization in a subset of human small cell lung cancer cell lines.
The Journal of biological chemistry 1987;262(34):16456-60.
1987: Jane Trepel; Oscar R Colamonici; K Kelly; G Schwab; R A Watt; Edward A Sausville; E S Jaffe; L M Neckers
Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.
Molecular and cellular biology 1987;7(7):2644-8.
1986: L M Neckers; S Bauer; R C McGlennen; Jane Trepel; K Rao; Warner Greene
Diltiazem inhibits transferrin receptor expression and causes G1 arrest in normal and neoplastic T cells.
Molecular and cellular biology 1986;6(12):4244-50.
1986: Oscar R Colamonici; Jane Trepel; C A Vidal; L M Neckers
Phorbol ester induces c-sis gene transcription in stem cell line K-562.
Molecular and cellular biology 1986;6(5):1847-50.
1986: S Matsushita; M Robert-Guroff; Jane Trepel; J Cossman; H Mitsuya; S Broder
Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2672-6.
1986: Oscar R Colamonici; Jane Trepel; L M Neckers
Megakaryocyte differentiation: studies at the molecular level using the K-562 cell line.
Progress in clinical and biological research 1986;215():187-91.
1986: L M Neckers; Jane Trepel
Transferrin receptor expression and the control of cell growth.
Cancer investigation 1986;4(5):461-70.
1985: Oscar R Colamonici; Jane Trepel; L M Neckers
Phorbol ester enhances deoxynucleoside incorporation while inhibiting proliferation of K-562 cells.
Cytometry 1985;6(6):591-6.
1985: L M Neckers; W K Funkhouser; Jane Trepel; J Cossman; H G Gratzner
Significant non-S-phase DNA synthesis visualized by flow cytometry in activated and in malignant human lymphoid cells.
Experimental cell research 1985;156(2):429-38.
1985: L M Neckers; G Yenokida; Jane Trepel; E Lipford; S James
Transferrin receptor induction is required for human B-lymphocyte activation but not for immunoglobulin secretion.
Journal of cellular biochemistry 1985;27(4):377-89.
1984: J Cossman; L M Neckers; Rita M Braziel; Jane Trepel; S J Korsmeyer; A Bakhshi
In vitro enhancement of immunoglobulin gene expression in chronic lymphocytic leukemia.
The Journal of clinical investigation 1984;73(2):587-92.
1982: H L Cooper; R Fagnani; J London; Jane Trepel; E P Lester
Effect of interferons on protein synthesis in human lymphocytes: enhanced synthesis of eight specific peptides in T cells and activation-dependent inhibition of overall protein synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(2):828-33.
1982: S I Goodman; R J Wyatt; Jane Trepel; L M Neckers
NAD glycohydrolase: enzyme characterization using intact mammalian erythrocytes.
Comparative biochemistry and physiology. B, Comparative biochemistry 1982;71(2):333-6.
1981: Robert G Rohwer; L M Neckers; Jane Trepel; D Carleton Gajdusek; R J Wyatt
Serotonin concentrations in brain and blood of scrapie-infected and normal hamsters and mice.
Brain research 1981;220(2):367-71.
1981: Jane Trepel; D M Chuang; N H Neff
Polypeptide hormones and chromatin-associated proteins act as acceptors for cholera toxin-catalyzed ADP-ribosylation.
Journal of neurochemistry 1981;36(2):538-43.
1977: Jane Trepel; D M Chuang; N H Neff
Transfer of ADP-ribose from NAD to choleragen: a subunit acts as catalyst and acceptor protein.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(12):5440-2.
1977: Jane Trepel; R J Wyatt; N H Neff
Differential distribution of type A and B monoamine oxidase in neuronal tissues.
European journal of pharmacology 1977;43(4):373-5.
1977: J A Fuentes; Jane Trepel; N H Neff
Monoamine oxidase activity in the cardiovascular system of young and aged rats.
Experimental gerontology 1977;12(3-4):113-5.