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Tohru Fukai

Research Profile

Chemicals & Drugs

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Takashi Kohno; Ronald D McKinney; Varadarajan Sudhahar; Norifumi Urao; Masuko Fukai; Takashi Ashino; Takao Hamakubo; Hiroko Iwanari; Tohru Fukai
Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.
Norifumi Urao; Gin-Fu Chen; Tohru Fukai; Seok-Jo Kim; Georg Kojda; Ronald D McKinney; Varadarajan Sudhahar; Masuko Fukai
Critical role of endothelial hydrogen peroxide in post-ischemic neovascularization.
Jasmina Profirovic; Elena Strekalova; Norifumi Urao; Masuko Fukai; Sudhahar Varadarajan; Alexandra V Andreeva; Tohru Fukai; René Hen; Aleksandar Krbanjevic; Tatyana Voyno-Yasenetskaya
A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor.

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2013: Takashi Kohno; Ronald D McKinney; Varadarajan Sudhahar; Norifumi Urao; Masuko Fukai; Takashi Ashino; Takao Hamakubo; Hiroko Iwanari; Tohru Fukai
Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(4):805-13.
2013: Norifumi Urao; Gin-Fu Chen; Tohru Fukai; Seok-Jo Kim; Georg Kojda; Ronald D McKinney; Varadarajan Sudhahar; Masuko Fukai
Critical role of endothelial hydrogen peroxide in post-ischemic neovascularization.
PloS one 2013;8(3):e57618.
2013: Jasmina Profirovic; Elena Strekalova; Norifumi Urao; Masuko Fukai; Sudhahar Varadarajan; Alexandra V Andreeva; Tohru Fukai; René Hen; Aleksandar Krbanjevic; Tatyana Voyno-Yasenetskaya
A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor.
Angiogenesis 2013;16(1):15-28.
2012: Kiyoshi Ozumi; Varadarajan Sudhahar; Masuko Fukai; Stefan Vogt; Gin-Fu Chen; Lydia Finney; Ha Won Kim; Takashi Kohno; Ronald D McKinney; Tohru Fukai
Role of copper transport protein antioxidant 1 in angiotensin II-induced hypertension: a key regulator of extracellular superoxide dismutase.
Hypertension 2012;60(2):476-86.
2012: Norifumi Urao; Tohru Fukai; Ronald D McKinney; Masuko Fukai
NADPH oxidase 2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells.
Stem cells (Dayton, Ohio) 2012;30(5):923-34.
2012: Jin Oshikawa; Cristiana Caliceti; Gin-Fu Chen; Tohru Fukai; Eiji Furuta; Seok-Jo Kim; Frank Kuhr; Irena Levitan; Ronald D McKinney; Masuko Fukai
Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells.
American journal of physiology. Heart and circulatory physiology 2012;302(3):H724-32.
2012: Mao Mao; Francisco R M Laurindo; Denise C Fernandes; Kristine Ansenberger-Fricano; Varadarajan Sudhahar; Leonardo Y Tanaka; Richard D Minshall; Ronald P Mason; Krisztian Stadler; Jeannette Vasquez-Vivar; Tohru Fukai; Marcelo Bonini
Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway.
Free radical biology & medicine 2012;52(2):427-35.
2011: Nihal Kaplan; Seok-Jo Kim; Ronald D McKinney; Yoshimasa Nakamura; Leslie B Poole; Masooma Razvi; Norifumi Urao; Tohru Fukai; Eiji Furuta; Masuko Fukai
Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis.
Free radical research 2011;45(10):1124-35.
2011: Tohru Fukai; Masuko Fukai
Superoxide dismutases: role in redox signaling, vascular function, and diseases.
Antioxidants & redox signaling 2011;15(6):1583-606.
2011: Stephen Wedgwood; Tohru Fukai; Satyan Lakshminrusimha; James A Russell; Paul T Schumacker; Robin Steinhorn
Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension.
Antioxidants & redox signaling 2011;15(6):1497-506.
2010: Takashi Ashino; Varadarajan Sudhahar; Norifumi Urao; Jin Oshikawa; Gin-Fu Chen; Huan Wang; Yuqing Huo; Lydia Finney; Stefan Vogt; Ronald D McKinney; Edward B Maryon; Jack H Kaplan; Masuko Fukai; Tohru Fukai
Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration.
Circulation research 2010;107(6):787-99.
2010: Markus P Schneider; Jennifer C Sullivan; Paul F Wach; Erika Ingrid Boesen; Tatsuo Yamamoto; Tohru Fukai; David G Harrison; David M Pollock; Jennifer Pollock
Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury.
Kidney international 2010;78(4):374-81.
2010: Marie K Schluterman; Shelby L Chapman; Grzegorz Korpanty; Kiyoshi Ozumi; Tohru Fukai; Hiromi Yanagisawa; Rolf Brekken
Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.
Disease models & mechanisms 2010;3(5-6):333-42.
2010: Norifumi Urao; Masooma Razvi; Jin Oshikawa; Ronald D McKinney; Rupal Chavda; Wadie F Bahou; Tohru Fukai; Masuko Fukai
IQGAP1 is involved in post-ischemic neovascularization by regulating angiogenesis and macrophage infiltration.
PloS one 2010;5(10):e13440.
2010: Jin Oshikawa; Norifumi Urao; Ha Won Kim; Nihal Kaplan; Masooma Razvi; Ronald McKinney; Leslie B Poole; Tohru Fukai; Masuko Fukai
Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice.
PloS one 2010;5(4):e10189.
2009: Tohru Fukai
Mitochondrial Thioredoxin: novel regulator for NADPH oxidase and angiotensin II-induced hypertension.
Hypertension 2009;54(2):224-5.
2009: Tohru Fukai
Extracellular SOD and aged blood vessels.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H10-2.
2009: Shinichi Itoh; Kiyoshi Ozumi; Ha Won Kim; Osamu Nakagawa; Ronald D McKinney; Rodney J Folz; Igor N Zelko; Masuko Fukai; Tohru Fukai
Novel mechanism for regulation of extracellular SOD transcription and activity by copper: role of antioxidant-1.
Free radical biology & medicine 2009;46(1):95-104.
2009: Lydia Finney; Stefan Vogt; Tohru Fukai; David Glesne
Copper and angiogenesis: unravelling a relationship key to cancer progression.
Clinical and experimental pharmacology & physiology 2009;36(1):88-94.
2008: Zhenyu Qin; Maria Carolina Gongora; Kiyoshi Ozumi; Shinichi Itoh; Kamran Akram; Masuko Fukai; David G Harrison; Tohru Fukai
Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function.
Hypertension 2008;52(5):945-51.
2008: Maria Carolina Gongora; Heinrich E Lob; Ulf Landmesser; Tomasz J Guzik; W David Martin; Kiyoski Ozumi; Susan M Wall; David Scott Wilson; Niren Murthy; Michael B Gravanis; Tohru Fukai; David G Harrison
Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.
The American journal of pathology 2008;173(4):915-26.
2008: Norifumi Urao; Hyoe Inomata; Masooma Razvi; Ha Won Kim; Kishore K Wary; Ronald McKinney; Tohru Fukai; Masuko Fukai
Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia.
Circulation research 2008;103(2):212-20.
2008: Yoshimasa Nakamura; Nikolay Patrushev; Hyoe Inomata; Dolly Mehta; Norifumi Urao; Ha Won Kim; Masooma Razvi; Vidisha Kini; Kalyankar Mahadev; Barry J Goldstein; Ronald McKinney; Tohru Fukai; Masuko Fukai
Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells.
Circulation research 2008;102(10):1182-91.
2008: Shinichi Itoh; Ha Won Kim; Osamu Nakagawa; Kiyoshi Ozumi; Susan Lessner; Hiroki Aoki; Kamran Akram; Ronald D McKinney; Masuko Fukai; Tohru Fukai
Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation.
The Journal of biological chemistry 2008;283(14):9157-67.
2008: Zhenyu Qin; Krzysztof J Reszka; Tohru Fukai; Neal L Weintraub
Extracellular superoxide dismutase (ecSOD) in vascular biology: an update on exogenous gene transfer and endogenous regulators of ecSOD.
Translational research : the journal of laboratory and clinical medicine 2008;151(2):68-78.
2007: Guoliang Ding; Mingui Fu; Qianhong Qin; William Lewis; Ha Won Kim; Tohru Fukai; Methode Bacanamwo; Chen Lab; Michael D Schneider; David J Mangelsdorf; Ronald M Evans; Qinglin Yang
Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage.
Cardiovascular research 2007;76(2):269-79.
2007: Tohru Fukai
Targeting proteasome worsens atherosclerosis.
Circulation research 2007;101(9):859-61.
2007: Ha Won Kim; Angela Lin; Robert E Guldberg; Masuko Fukai; Tohru Fukai
Essential role of extracellular SOD in reparative neovascularization induced by hindlimb ischemia.
Circulation research 2007;101(4):409-19.
2007: Tohru Fukai
Endothelial GTPCH in eNOS uncoupling and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1493-5.
2007: Tohru Fukai
Extracellular SOD inactivation in high-volume hypertension: role of hydrogen peroxide.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):442-4.
2006: Kyoko Umeji; Seiji Umemoto; Shinichi Itoh; Masakazu Tanaka; Shinji Kawahara; Tohru Fukai; Masunori Matsuzaki
Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-gamma, and aortic stiffness in hypercholesterolemia.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2522-32.
2006: Maria Carolina Gongora; Zhenyu Qin; Karine Laude; Ha Won Kim; Louise McCann; J Rodney Folz; Sergey Dikalov; Tohru Fukai; David G Harrison
Role of extracellular superoxide dismutase in hypertension.
Hypertension 2006;48(3):473-81.
2006: Minako Yamaoka-Tojo; Taiki Tojo; Ha Won Kim; Lula Hilenski; Nikolay A Patrushev; Lynn Zhang; Tohru Fukai; Masuko Fukai
IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):1991-7.
2006: Zhenyu Qin; Shinichi Itoh; Viktoria Jeney; Masuko Fukai; Tohru Fukai
Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):334-6.
2005: Samuel C Dudley; Nyssa E Hoch; Louise McCann; Clegg Honeycutt; Laura Diamandopoulos; Tohru Fukai; David G Harrison; Sergey Dikalov; Jonathan J Langberg
Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases.
Circulation 2005;112(9):1266-73.
2005: Viktoria Jeney; Shinichi Itoh; Maria Wendt; Quinton Gradek; Masuko Fukai; David G Harrison; Tohru Fukai
Role of antioxidant-1 in extracellular superoxide dismutase function and expression.
Circulation research 2005;96(7):723-9.
2005: YingJie Chen; Mingxiao Hou; Yunfang Li; Jay H Traverse; Ping Zhang; Daniela Salvemini; Tohru Fukai; Robert J Bache
Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heart.
American journal of physiology. Heart and circulatory physiology 2005;288(1):H133-41.
2005: Karine Laude; Hua Cai; Bruno Fink; Nyssa E Hoch; David S Weber; Louise McCann; Georg Kojda; Tohru Fukai; Harald Schmidt; Sergey Dikalov; Santhini Ramasamy; Graciela Gamez; Kathy K Griendling; David G Harrison
Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice.
American journal of physiology. Heart and circulatory physiology 2005;288(1):H7-12.
2004: Andrew D Nguyen; Shinichi Itoh; Viktoria Jeney; Hiromi Yanagisawa; Mitsuaki Fujimoto; Masuko Fukai; Tohru Fukai
Fibulin-5 is a novel binding protein for extracellular superoxide dismutase.
Circulation research 2004;95(11):1067-74.
2004: Minako Yamaoka-Tojo; Masuko Fukai; Lula Hilenski; Sergey Dikalov; Chen Lab; Taiki Tojo; Tohru Fukai; Mitsuaki Fujimoto; Nikolay A Patrushev; Ningning Wang; Christopher D Kontos; George S Bloom; Wayne R Alexander
IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.
Circulation research 2004;95(3):276-83.
2004: Michael E Davis; Isabella M Grumbach; Tohru Fukai; Alexis Cutchins; David G Harrison
Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding.
The Journal of biological chemistry 2004;279(1):163-8.
2003: Ulf Landmesser; Sergey Dikalov; S Russ Price; Louise McCann; Tohru Fukai; Steven M Holland; William E Mitch; David G Harrison
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.
The Journal of clinical investigation 2003;111(8):1201-9.
2003: Michael E Davis; Hua Cai; Louise McCann; Tohru Fukai; David G Harrison
Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training.
American journal of physiology. Heart and circulatory physiology 2003;284(4):H1449-53.
2002: Masuko Fukai; Yan Tang; Tohru Fukai; Sergey Dikalov; Yuxian Ma; Mitsuaki Fujimoto; Mark T Quinn; Patrick J Pagano; Chad Johnson; Wayne R Alexander
Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis.
Circulation research 2002;91(12):1160-7.
2002: H Ulrich Hink; Nalini Santanam; Sergey Dikalov; Louise McCann; Andrew D Nguyen; Sampath Parthasarathy; David G Harrison; Tohru Fukai
Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(9):1402-8.
2002: Tohru Fukai; Rodney J Folz; Ulf Landmesser; David G Harrison
Extracellular superoxide dismutase and cardiovascular disease.
Cardiovascular research 2002;55(2):239-49.
2002: H U Hink; Tohru Fukai
Extracellular superoxide dismutase, uric acid, and atherosclerosis.
Cold Spring Harbor symposia on quantitative biology 2002;67():483-90.
2001: JB Laursen; MJ Somers; S Kurz; Louise McCann; Ascan Warnholtz; Bruce Freeman; Margaret M Tarpey; Tohru Fukai; David G Harrison
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.
Circulation 2001;103(9):1282-8.
2000: K Mavromatis; Tohru Fukai; Matthew C Tate; N Chesler; D N Ku; Zorina S Galis
Early effects of arterial hemodynamic conditions on human saphenous veins perfused ex vivo.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(8):1889-95.
2000: Tohru Fukai; M R Siegfried; Masuko Fukai; Y Cheng; G Kojda; David G Harrison
Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training.
The Journal of clinical investigation 2000;105(11):1631-9.
1999: Tohru Fukai; M R Siegfried; Masuko Fukai; Kathy K Griendling; David G Harrison
Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension.
Circulation research 1999;85(1):23-8.
1998: Tohru Fukai; Zorina S Galis; X P Meng; Sampath Parthasarathy; David G Harrison
Vascular expression of extracellular superoxide dismutase in atherosclerosis.
The Journal of clinical investigation 1998;101(10):2101-11.
1998: N Inoue; Y Ohara; Tohru Fukai; David G Harrison; K Nishida
Probucol improves endothelial-dependent relaxation and decreases vascular superoxide production in cholesterol-fed rabbits.
The American journal of the medical sciences 1998;315(4):242-7.
1996: David G Harrison; N Inoue; Y Ohara; Tohru Fukai
Modulation of endothelial cell nitric oxide synthase expression.
Japanese circulation journal 1996;60(11):815-21.
1996: N Inoue; Santhini Ramasamy; Tohru Fukai; Robert M Nerem; David G Harrison
Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells.
Circulation research 1996;79(1):32-7.
1995: Tohru Fukai; S Koyanagi; H Tashiro; T Ichiki; H Tsutsui; T Matsumoto; Akira Takeshita
Adenosine triphosphate stress echocardiography in the detection of myocardial ischemia.
American journal of cardiac imaging 1995;9(4):237-44.
1995: Tohru Fukai; Kensuke Egashira; K Numaguchi; H Hata; T Takahashi; H Kasuya; M Sakata; Hiroaki Shimokawa; Akira Takeshita
Endothelin-1 is not involved in serotonin-induced coronary spasm in a swine model.
Cardiovascular research 1995;30(2):193-9.
1995: H Hata; Y Ohara; T Kuga; Tohru Fukai; H Kasuya; H Tomoike; Akira Takeshita
Vasoreactivity and restenosis after coronary angioplasty in the atherosclerotic pig model.
Coronary artery disease 1995;6(6):503-11.
1995: H Tsutsui; S Ando; Tohru Fukai; M Kuroiwa; Kensuke Egashira; M Sasaki; Yasuo Kuwabara; S Koyanagi; Akira Takeshita
Detection of angina-provoking coronary stenosis by resting iodine 123 metaiodobenzylguanidine scintigraphy in patients with unstable angina pectoris.
American heart journal 1995;129(4):708-15.
1994: Akira Ito; Hiroaki Shimokawa; R Nakaike; Tohru Fukai; M Sakata; T Takayanagi; Kensuke Egashira; Akira Takeshita
Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model.
Circulation 1994;90(5):2425-31.
1993: Tohru Fukai; S Koyanagi; Akira Takeshita
Role of coronary vasospasm in the pathogenesis of myocardial infarction: study in patients with no significant coronary stenosis.
American heart journal 1993;126(6):1305-11.
1993: H Hata; Kensuke Egashira; Tohru Fukai; Y Ohara; H Kasuya; T Takahashi; Akira Takeshita
The role of endothelium-derived nitric oxide in acetylcholine-induced coronary vasoconstriction in closed-chest pigs.
Coronary artery disease 1993;4(10):891-8.
1993: Tohru Fukai; Kensuke Egashira; H Hata; K Numaguchi; Y Ohara; T Takahashi; H Tomoike; Akira Takeshita
Serotonin-induced coronary spasm in a swine model. A minor role of defective endothelium-derived relaxing factor.
Circulation 1993;88(4 Pt 1):1922-30.
1993: T Takahashi; Tohru Fukai; H Hata; H Kasuya; T Kuga; Kensuke Egashira; Akira Takeshita
Effects of a new calcium antagonist, CD-832, on experimental coronary artery spasm in miniature pigs.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1993;7(2):265-71.
1992: Tohru Fukai; Hiromi Ishibashi; T Noda; Kazufumi Dohmen; J Kudo; Seiho Nagafuchi; K Sueishi; T Yamasaki; H Sameshima
Nodular regenerative hyperplasia of the liver with portal vein thrombosis and hyperplasia of the adrenal gland.
Gastroenterologia Japonica 1992;27(1):108-14.
1990: H Isobe; Tohru Fukai; H Iwamoto; M Satoh; M Tokumatsu; Hironori Sakai; B Andoh; S Sakamoto; Hajime Nawata
Liver abscess complicating intratumoral ethanol injection therapy for HCC.
The American journal of gastroenterology 1990;85(12):1646-8.