FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

todd golde

Research Profile

Chemicals & Drugs

Disorders

Living Beings

Anatomy

Physiology

Co-author Network

Publications

TOP 3
Christophe Verbeeck; Rosa Rademakers; Georgia Taylor; Carolina Ceballos-Diaz; Pritam Das; Mariely Dejesus-Hernandez; Qiudong Deng; Dennis W Dickson; todd golde; Jannet Kocerha; Thomas Kukar
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
Brenda D Moore; Tina Moroni; Tom L Kukar; Thomas B Ladd; Yona Levites; Ann-Marie Baine; Paramita Chakrabarty; Pritam Das; Dennis W Dickson; todd golde
Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.
Sarah A Sagi; Sascha Weggen; Kellen D Winden; todd golde; Jeremy C Koo; Thomas L Kukar; Christian B Lessard; Hiroko Maruyama; Edward H Koo
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of todd golde (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Christophe Verbeeck; Rosa Rademakers; Georgia Taylor; Carolina Ceballos-Diaz; Pritam Das; Mariely Dejesus-Hernandez; Qiudong Deng; Dennis W Dickson; todd golde; Jannet Kocerha; Thomas Kukar
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
Molecular neurodegeneration 2012;7():53.
2012: Brenda D Moore; Tina Moroni; Tom L Kukar; Thomas B Ladd; Yona Levites; Ann-Marie Baine; Paramita Chakrabarty; Pritam Das; Dennis W Dickson; todd golde
Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.
Alzheimer's research & therapy 2012;4(3):18.
2011: Sarah A Sagi; Sascha Weggen; Kellen D Winden; todd golde; Jeremy C Koo; Thomas L Kukar; Christian B Lessard; Hiroko Maruyama; Edward H Koo
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
The Journal of biological chemistry 2011;286(46):39794-803.
2011: Thomas L Kukar; Thomas B Ladd; Kim Malphrus; Hiroko Maruyama; Brenda Moore; Sean A Pintchovski; Zhao Ren; Paul Robertson; Maralyssa A Bann; Guriqbal S Basi; Barbara A Cottrell; Pritam Das; Simone Eggert; Karen Jansen-West; Edward H Koo; todd golde
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
The Journal of biological chemistry 2011;286(46):39804-12.
2011: Paramita Chakrabarty; Carolina Ceballos-Diaz; Wen-Lang Lin; Amanda Beccard; Karen Jansen-West; Nikolaus R McFarland; Christopher Janus; dennis dickson; Pritam Das; todd golde
Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.
Nature neuroscience 2011;14(6):694-6.
2011: Allan Wang; Pritam Das; Robert C Switzer; todd golde; Joanna L Jankowsky
Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(11):4124-36.
2011: todd golde; Lon S Schneider; Edward H Koo
Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift.
Neuron 2011;69(2):203-13.
2011: Yiying Zhang; Yu Zhen; Zhipeng Xu; Yun Yue; Yuanlin Dong; todd golde; Robert D Moir; Rudolph E Tanzi; Zhongcong Xie
Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.
PloS one 2011;6(11):e27019.
2011: todd golde; Bruce T Lamb; Douglas Galasko
Right sizing funding for Alzheimer's disease.
Alzheimer's research & therapy 2011;3(3):17.
2011: Paramita Chakrabarty; Amanda Herring; Carolina Ceballos-Diaz; Pritam Das; todd golde
Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo.
Molecular neurodegeneration 2011;6():16.
2010: Nikisha Carty; Daniel Lee; Chad Dickey; Carolina Ceballos-Diaz; Karen Jansen-West; todd golde; Marcia N Gordon; Dave Morgan; Kevin Nash
Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain.
Journal of neuroscience methods 2010;194(1):144-53.
2010: Xavier Meckler; Jelita Roseman; Pritam Das; Haipeng Cheng; Susan Pei; Marcia Keat; Breanne Kassarjian; todd golde; Angèle T Parent; Gopal Thinakaran
Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(48):16160-9.
2010: Jada Lewis; todd golde
Sorting out frontotemporal dementia?
Neuron 2010;68(4):601-3.
2010: Jose F Abisambra; Laura J Blair; Shannon E Hill; Jeffrey R Jones; Clara Kraft; Justin Rogers; John Koren; Umesh Jinwal; Lisa Lawson; Amelia G Johnson; Donna Wilcock; John C O'Leary; Karen Jansen-West; Martin Muschol; todd golde; Edwin J Weeber; Jessica Banko; Chad A Dickey
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(46):15374-82.
2010: Peter Grudzien; Shelly Lo; Kathy S Albain; Patricia Robinson; Prabha Rajan; Peter R Strack; todd golde; Lucio Miele; Kimberly E Foreman
Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.
Anticancer research 2010;30(10):3853-67.
2010: Antonio Pannuti; Kimberly Foreman; Paola Rizzo; Clodia Osipo; todd golde; Barbara Osborne; Lucio Miele
Targeting Notch to target cancer stem cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(12):3141-52.
2010: todd golde; Leonard Petrucelli; Jada Lewis
Targeting Abeta and tau in Alzheimer's disease, an early interim report.
Experimental neurology 2010;223(2):252-66.
2010: Paramita Chakrabarty; Carolina Ceballos-Diaz; Amanda Beccard; Christopher Janus; dennis dickson; todd golde; Pritam Das
IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(9):5333-43.
2010: Bart De Strooper; Robert Vassar; todd golde
The secretases: enzymes with therapeutic potential in Alzheimer disease.
Nature reviews. Neurology 2010;6(2):99-107.
2010: Paramita Chakrabarty; Karen Jansen-West; Amanda Beccard; Carolina Ceballos-Diaz; Yona Levites; Christophe Verbeeck; Abba C Zubair; dennis dickson; todd golde; Pritam Das
Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(2):548-59.
2009: Kelly L Sudol; Michael A Mastrangelo; Wade C Narrow; Maria E Frazer; Yona R Levites; todd golde; Howard Federoff; William J Bowers
Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(12):2031-40.
2009: Carlo Sala Frigerio; Thomas L Kukar; Abdul Fauq; Paul C Engel; todd golde; Dominic M Walsh
An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.
Biochemistry 2009;48(46):10894-904.
2009: Hong-Shuo Sun; Michael F Jackson; Loren martin; Karen Jansen; Lucy Teves; Hong Cui; Shigeki Kiyonaka; Yasuo Mori; Michael Jones; Joan P Forder; todd golde; Beverley A Orser; John F MacDonald; Michael Tymianski
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.
Nature neuroscience 2009;12(10):1300-7.
2009: Yong-Jie Zhang; Ya-Fei Xu; Casey Cook; Tania F Gendron; Paul Roettges; Christopher D Link; Wen-Lang Lin; Jimei Tong; Monica Castanedes-Casey; Peter Ash; Jennifer Gass; Vijayaraghavan Rangachari; Emanuele Buratti; Francisco Baralle; todd golde; dennis dickson; Leonard Petrucelli
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7607-12.
2009: todd golde; Thomas L Kukar
Medicine. Avoiding unintended toxicity.
Science (New York, N.Y.) 2009;324(5927):603-4.
2009: todd golde; Michael S Wolfe; Doron C Greenbaum
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.
Seminars in cell & developmental biology 2009;20(2):225-30.
2009: Fiona E McAlpine; Jae-Kyung Lee; Ashley S Harms; Kelly A Ruhn; Mathew Blurton-Jones; John Hong; Pritam Das; todd golde; Frank M LaFerla; Salvatore Oddo; Armin Blesch; Malú G Tansey
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology.
Neurobiology of disease 2009;34(1):163-77.
2009: Nader Rahimi; todd golde; Rosana D Meyer
Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells.
Cancer research 2009;69(6):2607-14.
2009: Ok Hyun Cho; Hyun Mu Shin; Lucio Miele; todd golde; Abdul Fauq; Lisa M Minter; Barbara A Osborne
Notch regulates cytolytic effector function in CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3380-9.
2009: todd golde; Pritam Das; Yona Levites
Quantitative and mechanistic studies of Abeta immunotherapy.
CNS & neurological disorders drug targets 2009;8(1):31-49.
2009: Ila Joshi; Lisa M Minter; Janice Telfer; Renée M Demarest; Anthony John Capobianco; Jon C Aster; Piotr Sicinski; Abdul Fauq; todd golde; Barbara A Osborne
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.
Blood 2009;113(8):1689-98.
2009: todd golde; Victor M Miller
Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases.
Alzheimer's research & therapy 2009;1(2):5.
2009: Ann Donnelly; Douglas Galasko; todd golde; Frances Mulvany; Gordon K Wilcock
Welcome to Alzheimer's research & therapy.
Alzheimer's research & therapy 2009;1(1):1.
2009: Monica Garcia-Alloza; Meenakshi Subramanian; Diana Thyssen; Laura A Borrelli; Abdul Fauq; Pritam Das; todd golde; Bradley T Hyman; Brian J Bacskai
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.
Molecular neurodegeneration 2009;4():19.
2009: Paola Rizzo; Clodia Osipo; Antonio Pannuti; todd golde; Barbara Osborne; Lucio Miele
Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer.
Advances in enzyme regulation 2009;49(1):134-41.
2009: Iana Parvanova; Sabrina Epiphanio; Abdul Fauq; todd golde; Miguel Prudêncio; Maria M Mota
A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity.
PloS one 2009;4(4):e5078.
2009: todd golde
The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease.
Molecular neurodegeneration 2009;4():8.
2009: todd golde; Leonard Petrucelli
"What kills neurons in neurodegenerative diseases?", a review series in an open access journal.
Molecular neurodegeneration 2009;4():7.
2008: Paola Rizzo; Clodia Osipo; Kimberly E Foreman; todd golde; Barbara A Osborne; Lucio Miele
Rational targeting of Notch signaling in cancer.
Oncogene 2008;27(38):5124-31.
2008: Jeremy B Samon; Ameya Champhekar; Lisa M Minter; Janice C Telfer; Lucio Miele; Abdul Fauq; Pritam Das; todd golde; Barbara A Osborne
Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells.
Blood 2008;112(5):1813-21.
2008: Peizhou Jiang; Li-Wen Ko; Karen R Jansen; todd golde; Shu-Hui C. Yen
Using leucine zipper to facilitate alpha-synuclein assembly.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3165-74.
2008: Clodia Osipo; P Patel; Paola Rizzo; A G Clementz; L Hao; todd golde; Lucio Miele
ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor.
Oncogene 2008;27(37):5019-32.
2008: Patricia Spilman; Pierre Lessard; Mamta Sattavat; Clarissa Bush; Thomas Tousseyn; Eric J Huang; Kurt Giles; todd golde; Pritam Das; Abdul Fauq; Stanley B Prusiner; Stephen J DeArmond
A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10595-600.
2008: Eva Czirr; Barbara A Cottrell; Stefanie Leuchtenberger; Thomas Kukar; Thomas B Ladd; Hermann Esselmann; Sabine Paul; Robert Schubenel; Justin W Torpey; Claus U Pietrzik; todd golde; Jens Wiltfang; Karlheinz Baumann; Edward H Koo; Sascha Weggen
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
The Journal of biological chemistry 2008;283(25):17049-54.
2008: Thomas L Kukar; Thomas B Ladd; Maralyssa A Bann; Patrick C Fraering; Rajeshwar Narlawar; Ghulam M Maharvi; Brent Healy; Robert Chapman; Alfred T Welzel; Robert W Price; Brenda Moore; Vijayaraghavan Rangachari; Bernadette Cusack; Jason Eriksen; Karen Jansen-West; Christophe Verbeeck; Debra Yager; Christopher B Eckman; Wenjuan Ye; Sarah A Sagi; Barbara A Cottrell; Justin Torpey; Terrone L Rosenberry; Abdul Fauq; Michael S Wolfe; Boris Schmidt; Dominic M Walsh; Edward H Koo; todd golde
Substrate-targeting gamma-secretase modulators.
Nature 2008;453(7197):925-9.
2008: Jungsu Kim; Victor M Miller; Yona Levites; Karen Jansen West; Craig Zwizinski; Brenda D Moore; Fredrick J Troendle; Maralyssa Bann; Christophe Verbeeck; Robert W Price; Lisa A Smithson; Leilani Sonoda; Kayleigh Wagg; Vijayaraghavan Rangachari; Fanggeng Zou; Steven G Younkin; Neill Graff-Radford; dennis dickson; Terrone L Rosenberry; todd golde
BRI2 (ITM2b) inhibits Abeta deposition in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(23):6030-6.
2008: Joel N Buxbaum; Zhengyi Ye; Natàlia Reixach; Linsey Friske; Coree Levy; Pritam Das; todd golde; Eliezer Masliah; Amanda R Roberts; Tamas Bartfai
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2681-6.
2008: Thomas Kukar; todd golde
Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.
Current topics in medicinal chemistry 2008;8(1):47-53.
2008: Tanapat Palaga; Chayanit Buranaruk; Sirirat Rengpipat; Abdul Fauq; todd golde; Stefan H E Kaufmann; Barbara A Osborne
Notch signaling is activated by TLR stimulation and regulates macrophage functions.
European journal of immunology 2008;38(1):174-83.
2008: Clodia Osipo; todd golde; Barbara A Osborne; Lucio Miele
Off the beaten pathway: the complex cross talk between Notch and NF-kappaB.
Laboratory investigation; a journal of technical methods and pathology 2008;88(1):11-7.
2007: Abdul Fauq; Katherine Simpson; Ghulam M Maharvi; todd golde; Pritam Das
A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.
Bioorganic & medicinal chemistry letters 2007;17(22):6392-5.
2007: Tong Li; Hongjin Wen; CORY BRAYTON; Pritam Das; Lisa A Smithson; Abdul Fauq; Xing Fan; Barbara J Crain; Donald L Price; todd golde; Charles G Eberhart; Philip C Wong
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.
The Journal of biological chemistry 2007;282(44):32264-73.
2007: Douglas Galasko; Neill R Graff-Radford; Susanne May; Suzanne Hendrix; Barbara A Cottrell; Sarah A Sagi; Gary Mather; Mark Laughlin; Kenton H Zavitz; Edward Swabb; todd golde; Michael Murphy; Edward H Koo
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals.
Alzheimer disease and associated disorders 2007;21(4):292-9.
2007: Stephen M Ostrowski; Brandy L Wilkinson; todd golde; Gary Landreth
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
The Journal of biological chemistry 2007;282(37):26832-44.
2007: Christine L Curry; Laura L Reed; Eugenia Broude; todd golde; Lucio Miele; Kimberly E Foreman
Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling.
Molecular cancer therapeutics 2007;6(7):1983-92.
2007: Jungsu Kim; Luisa Onstead; Suzanne Randle; Robert Price; Lisa A Smithson; Craig Zwizinski; dennis dickson; todd golde; Eileen McGowan
Abeta40 inhibits amyloid deposition in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(3):627-33.
2007: Thomas Kukar; Sonya Prescott; Jason Eriksen; Vallie M Holloway; Michael Murphy; Edward H Koo; todd golde; Michelle M. Nicolle
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
BMC neuroscience 2007;8():54.
2007: Patricia A Lawlor; Ross J Bland; Pritam Das; Robert W Price; Vallie M Holloway; Lisa A Smithson; Bridget L Dicker; Matthew J During; Deborah Young; todd golde
Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.
Molecular neurodegeneration 2007;2():11.
2007: todd golde
The pathogenesis of Alzheimer's disease and the role of Abeta42.
CNS spectrums 2007;12(1 Suppl 1):4-6.
2006: Lucio Miele; todd golde; Barbara Osborne
Notch signaling in cancer.
Current molecular medicine 2006;6(8):905-18.
2006: todd golde; dennis dickson; Michael Hutton
Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease.
Current Alzheimer research 2006;3(5):421-30.
2006: Yona Levites; Lisa A Smithson; Robert W Price; Rachel S Dakin; Bin Yuan; Michael R Sierks; Jungsu Kim; Eileen McGowan; Dana Kim Reed; Terrone L Rosenberry; Pritam Das; todd golde
Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2576-8.
2006: Yona Levites; Karen Jansen; Lisa A Smithson; Rachel Dakin; Vallie M Holloway; Pritam Das; todd golde
Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(46):11923-8.
2006: Pritam Das; todd golde
Dysfunction of TGF-beta signaling in Alzheimer's disease.
The Journal of clinical investigation 2006;116(11):2855-7.
2006: todd golde
Disease modifying therapy for AD?
Journal of neurochemistry 2006;99(3):689-707.
2006: Bradley Boeve; Matt Baker; dennis dickson; Joseph E Parisi; Caterina Giannini; Keith A Josephs; Michael Hutton; Stuart Pickering-Brown; Rosa Rademakers; David F Tang-Wai; Clifford R Jack; Kejal Kantarci; Maria M Shiung; todd golde; Glenn Smith; Yonas E Geda; David S. Knopman; Ronald C. Petersen
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Brain : a journal of neurology 2006;129(Pt 11):3103-14.
2006: Andrew C Nyborg; Thomas B Ladd; Karen Jansen; Thomas Kukar; todd golde
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1671-9.
2006: Toru Sato; Andrew C Nyborg; Nobuhisa Iwata; Thekla S Diehl; Takaomi C Saido; todd golde; Michael S Wolfe
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.
Biochemistry 2006;45(28):8649-56.
2006: Justin H Nguyen; Satoshi Yamamoto; Jeffery L Steers; Daniel Sevlever; Wenlang Lin; Naoki Shimojima; Monica Castanedes-Casey; Petrina Genco; todd golde; Elliott Richelson; dennis dickson; Michael McKinney; Christopher B Eckman
Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice.
Journal of hepatology 2006;44(6):1105-14.
2006: Ronald L. Klein; Robert D Dayton; Nancy J Leidenheimer; Karen Jansen; todd golde; Richard M Zweig
Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(3):517-27.
2006: Lauren Herl; Alberto Lleo; Anne V Thomas; Andrew C Nyborg; Karen Jansen; todd golde; Bradley T Hyman; Oksana Berezovska
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.
Biochemical and biophysical research communications 2006;340(2):668-74.
2006: Michael Murphy; todd golde
Inclusion-body myositis and Alzheimer disease: two sides of the same coin, or different currencies altogether?
Neurology 2006;66(2 Suppl 1):S65-8.
2006: Hyun Mu Shin; Lisa M Minter; Ok Hyun Cho; Sridevi Gottipati; Abdul Fauq; todd golde; Gail E Sonenshein; Barbara A Osborne
Notch1 augments NF-kappaB activity by facilitating its nuclear retention.
The EMBO journal 2006;25(1):129-38.
2006: Andrew C Nyborg; Lauren Herl; Oksana Berezovska; Anne V Thomas; Thomas B Ladd; Karen Jansen; Bradley T Hyman; todd golde
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.
Molecular neurodegeneration 2006;1():16.
2006: Andrew C Nyborg; Thomas B Ladd; Craig W Zwizinski; James J Lah; todd golde
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.
Molecular neurodegeneration 2006;1():3.
2006: Pritam Das; Lisa A Smithson; Robert W Price; Vallie M Holloway; Yona Levites; Paramita Chakrabarty; todd golde
Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy.
Journal of neuroinflammation 2006;3():17.
2006: Yona Levites; Pritam Das; Robert W Price; Marjorie J Rochette; Lisa A Kostura; Eileen McGowan; Michael Murphy; todd golde
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.
The Journal of clinical investigation 2006;116(1):193-201.
2006: Jun Wang; Dirk Beher; Andrew C Nyborg; Mark S Shearman; todd golde; Alison Goate
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
Journal of neurochemistry 2006;96(1):218-27.
2006: Stefanie Leuchtenberger; Markus P Kummer; Thomas Kukar; Eva Czirr; Nicole Teusch; Sarah A Sagi; Rebecca Berdeaux; Claus U Pietrzik; Thomas B Ladd; todd golde; Edward H Koo; Sascha Weggen
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
Journal of neurochemistry 2006;96(2):355-65.
2005: Christine L Curry; Laura L Reed; todd golde; Lucio Miele; Brian J Nickoloff; Kimberly E Foreman
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.
Oncogene 2005;24(42):6333-44.
2005: Eileen McGowan; Fiona Pickford; Jungsu Kim; Luisa Onstead; Jason Eriksen; Cindy Yu; Lisa Skipper; Michael Murphy; Jenny Beard; Pritam Das; Karen Jansen; Michael W DeLucia; Wen-Lang Lin; Georgia Dolios; Rong Wang; Christopher B Eckman; dennis dickson; Michael Hutton; John Hardy; todd golde
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Neuron 2005;47(2):191-9.
2005: Lisa M Minter; Danielle M Turley; Pritam Das; Hyun Mu Shin; Ila Joshi; Rebecca G Lawlor; Ok Hyun Cho; Tanapat Palaga; Sridevi Gottipati; Janice C Telfer; Lisa Kostura; Abdul Fauq; Katherine Simpson; Kimberly A Such; Lucio Miele; todd golde; Stephen D Miller; Barbara A Osborne
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.
Nature immunology 2005;6(7):680-8.
2005: todd golde; Brian J Bacskai
Bringing amyloid into focus.
Nature biotechnology 2005;23(5):552-4.
2005: Thomas Kukar; Michael Murphy; Jason Eriksen; Sarah A Sagi; Sascha Weggen; Tawnya E Smith; Thomas B Ladd; Murad A Khan; Rajashaker Kache; Jenny Beard; Mark Dodson; Sami Merit; Victor V Ozols; PZ Anastasiadis; Pritam Das; Abdul Fauq; Edward H Koo; todd golde
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.
Nature medicine 2005;11(5):545-50.
2005: todd golde; Christopher Janus
Homing in on intracellular Abeta?
Neuron 2005;45(5):639-42.
2005: todd golde
The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease.
Brain pathology (Zurich, Switzerland) 2005;15(1):84-7.
2004: Andrew C Nyborg; Karen Jansen; Thomas B Ladd; Abdul Fauq; todd golde
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.
The Journal of biological chemistry 2004;279(41):43148-56.
2004: Yama Akbari; Brian D Hitt; Michael Murphy; Nabil N Dagher; Bertrand P Tseng; Kim N Green; todd golde; Frank M LaFerla
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.
Biochemical and biophysical research communications 2004;322(4):1145-52.
2004: Andrew C Nyborg; Anna Y Kornilova; Karen Jansen; Thomas B Ladd; Michael S Wolfe; todd golde
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.
The Journal of biological chemistry 2004;279(15):15153-60.
2003: Martin Ramsden; Andrew C Nyborg; Michael Murphy; Lilly Chang; Frank Z Stanczyk; todd golde; Christian J Pike
Androgens modulate beta-amyloid levels in male rat brain.
Journal of neurochemistry 2003;87(4):1052-5.
2003: Pritam Das; Svetlana Chapoval; Victor Howard; Chella S David; todd golde
Immune responses against Abeta1-42 in HLA class II transgenic mice: implications for Abeta1-42 immune-mediated therapies.
Neurobiology of aging 2003;24(7):969-76.
2003: Bruno Martoglio; todd golde
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs.
Human molecular genetics 2003;12 Spec No 2():R201-6.
2003: Pritam Das; Victor Howard; Nicole Loosbrock; dennis dickson; Michael Murphy; todd golde
Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8532-8.
2003: Tanapat Palaga; Lucio Miele; todd golde; Barbara A Osborne
TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3019-24.
2003: Sascha Weggen; Jason Eriksen; Sarah A Sagi; Claus U Pietrzik; Victor V Ozols; Abdul Fauq; todd golde; Edward H Koo
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.
The Journal of biological chemistry 2003;278(34):31831-7.
2003: Sarah A Sagi; Sascha Weggen; Jason Eriksen; todd golde; Edward H Koo
The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production.
The Journal of biological chemistry 2003;278(34):31825-30.
2003: Sascha Weggen; Jason Eriksen; Sarah A Sagi; Claus U Pietrzik; todd golde; Edward H Koo
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.
The Journal of biological chemistry 2003;278(33):30748-54.
2003: Jason Eriksen; Sarah A Sagi; Tawnya E Smith; Sascha Weggen; Pritam Das; D C McLendon; Victor V Ozols; Kevin W Jessing; Kenton H Zavitz; Edward H Koo; todd golde
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.
The Journal of clinical investigation 2003;112(3):440-9.
2003: Salvatore Oddo; Antonella Caccamo; Jason D Shepherd; Michael Murphy; todd golde; Rakez Kayed; Raju Metherate; Mark P Mattson; Yama Akbari; Frank M LaFerla
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.
Neuron 2003;39(3):409-21.
2003: Siân C Piper; Zareen Amtul; Laura Galiñanes-Garcia; Victor G Howard; Chewki Ziani-Cherif; Chris McLendon; Marjorie J Rochette; Abdul Fauq; todd golde; Michael Murphy
Peptide-based, irreversible inhibitors of gamma-secretase activity.
Biochemical and biophysical research communications 2003;305(3):529-33.
2003: Michael Murphy; Pritam Das; Andrew C Nyborg; Marjorie J Rochette; Mark W Dodson; Nicole M Loosbrock; Terrance M Souder; Chris McLendon; Sami L Merit; Siân C Piper; Karen R Jansen; todd golde
Overexpression of nicastrin increases Abeta production.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1138-40.
2003: todd golde; Christopher B Eckman
Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis.
Science's STKE : signal transduction knowledge environment 2003;2003(172):RE4.
2003: todd golde
Alzheimer disease therapy: can the amyloid cascade be halted?
The Journal of clinical investigation 2003;111(1):11-8.
2002: Pritam Das; todd golde
Open peer commentary regarding Abeta immunization and CNS inflammation by Pasinetti et al.
Neurobiology of aging 2002;23(5):671-4; discussion 683-4.
2002: todd golde
Inflammation takes on Alzheimer disease.
Nature medicine 2002;8(9):936-8.
2002: Chris P Ponting; Michael Hutton; Andrew C Nyborg; Matthew Baker; Karen Jansen; todd golde
Identification of a novel family of presenilin homologues.
Human molecular genetics 2002;11(9):1037-44.
2002: Michael C Sugarman; Tritia R Yamasaki; Salvatore Oddo; Julio C Echegoyen; Michael Murphy; todd golde; Mehrdad Jannatipour; Malcolm Leissring; Frank M LaFerla
Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6334-9.
2002: Malcolm Leissring; Michael Murphy; Tonya R Mead; Yama Akbari; Michael C Sugarman; Mehrdad Jannatipour; Brigitte Anliker; Ulrike Müller; Paul Saftig; Bart De Strooper; Michael S Wolfe; todd golde; Frank M LaFerla
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4697-702.
2002: Michael Murphy; Sacha N Uljon; todd golde; Rong Wang
FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants.
Biochimica et biophysica acta 2002;1586(2):199-209.
2002: Zareen Amtul; Patrick A Lewis; Sian Piper; Richard Crook; Matt Baker; Kirk Findlay; Andrew Singleton; Marion Hogg; Linda Younkin; Steven G Younkin; John Hardy; Michael Hutton; Bradley Boeve; David F Tang-Wai; todd golde
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
Neurobiology of disease 2002;9(2):269-73.
2002: Suzanne E Wahrle; Pritam Das; Andrew C Nyborg; Chris McLendon; Mikio Shoji; Takeshi Kawarabayashi; Linda Younkin; Steven G Younkin; todd golde
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.
Neurobiology of disease 2002;9(1):11-23.
2002: David F Tang-Wai; P Lewis; Bradley Boeve; Michael Hutton; todd golde; Matthew Baker; John Hardy; V Michels; Robert J Ivnik; C Jack; Ronald C. Petersen
Familial frontotemporal dementia associated with a novel presenilin-1 mutation.
Dementia and geriatric cognitive disorders 2002;14(1):13-21.
2001: Donna L McPhie; todd golde; Christopher B Eckman; Debra Yager; J B Brant; Rachael L Neve
beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
Brain research. Molecular brain research 2001;97(1):103-13.
2001: C Y Ni; Michael Murphy; todd golde; Graham Carpenter
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase.
Science (New York, N.Y.) 2001;294(5549):2179-81.
2001: Sascha Weggen; Jason Eriksen; Pritam Das; Sarah A Sagi; Rong Wang; Claus U Pietrzik; Kirk Findlay; Tawnya E Smith; Michael Murphy; T Bulter; David E Kang; NR Marquez-Sterling; todd golde; Edward H Koo
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
Nature 2001;414(6860):212-6.
2001: JJ Palacino; Michael Murphy; Ohoshi Murayama; K Iwasaki; M Fujiwara; Akihiko Takashima; todd golde; Benjamin Wolozin
Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion.
The Journal of biological chemistry 2001;276(42):38563-9.
2001: Pritam Das; Michael Murphy; Linda Younkin; Steven G Younkin; todd golde
Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
Neurobiology of aging 2001;22(5):721-7.
2001: Sharie J Haugabook; Debra Yager; Elizabeth A Eckman; todd golde; Steven G Younkin; Christopher B Eckman
High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta).
Journal of neuroscience methods 2001;108(2):171-9.
2001: Patrick A Lewis; S Piper; Matt Baker; Luisa Onstead; Michael Murphy; John Hardy; Rong Wang; Eileen McGowan; todd golde
Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides.
Biochimica et biophysica acta 2001;1537(1):58-62.
2001: Amritpal Mudher; S Chapman; J Richardson; Ayodeji A Asuni; Graham Gibb; CC Pollard; Richard Killick; T Iqbal; L Raymond; Ian Varndell; Paul Sheppard; Andrew Makoff; E Gower; Peter E Soden; P Lewis; Michael Murphy; todd golde; H T R Rupniak; Brian H Anderton; Simon Lovestone
Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):4987-95.
2001: todd golde; Steven G Younkin
Presenilins as therapeutic targets for the treatment of Alzheimer's disease.
Trends in molecular medicine 2001;7(6):264-9.
2001: Inga Pinnix; U Musunuru; Han Tun; A Sridharan; todd golde; Christopher B Eckman; Chewki Ziani-Cherif; Luisa Onstead; Kumar Sambamurti
A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.
The Journal of biological chemistry 2001;276(1):481-7.
2001: Sharie J Haugabook; T Le; Debra Yager; Brenda M Zenk; B M Healy; Elizabeth A Eckman; CM Prada; Linda Younkin; P Murphy; Inga Pinnix; Luisa Onstead; Kumar Sambamurti; todd golde; dennis dickson; Steven G Younkin; Christopher B Eckman
Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):16-18.
2000: Chris McLendon; T Xin; Chewki Ziani-Cherif; Michael Murphy; Kirk Findlay; Patrick A Lewis; Inga Pinnix; Kumar Sambamurti; Rong Wang; Abdul Fauq; todd golde
Cell-free assays for gamma-secretase activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2383-6.
2000: Henry Houlden; M Baker; E McGowan; P Lewis; Michael Hutton; Richard Crook; Nicholas W Wood; Samir Kumar-Singh; J Geddes; M Swash; Francesco Scaravilli; Janice L Holton; Tammaryn Lashley; T Tomita; T Hashimoto; Auli Verkkoniemi; Hannu Kalimo; Mirja Somer; Anders Paetau; J J Martin; Christine Van Broeckhoven; todd golde; John Hardy; Matti Haltia; Tamas Revesz
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
Annals of neurology 2000;48(5):806-8.
2000: Patrick A Lewis; Jordi Perez-Tur; todd golde; John Hardy
The presenilin 1 C92S mutation increases abeta 42 production.
Biochemical and biophysical research communications 2000;277(1):261-3.
2000: Michael Murphy; Sacha N Uljon; Paul E Fraser; Abdul Fauq; H A Lookingbill; Kirk Findlay; Tawnya E Smith; Patrick A Lewis; D C McLendon; Rong Wang; todd golde
Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.
The Journal of biological chemistry 2000;275(34):26277-84.
2000: todd golde; Christopher B Eckman; Steven G Younkin
Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease.
Biochimica et biophysica acta 2000;1502(1):172-87.
2000: Michael Murphy; Rong Wang; Paul E Fraser; Abdul Fauq; todd golde
An empirical model of gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():233-40.
1999: Hanna Rennert; todd golde; Robert B Wilson; Steven L Spitalnik; Vivianna M Van Deerlin; Debra G B Leonard
A novel, non-nested reverse-transcriptase polymerase chain reaction (RT-PCR) test for the detection of the t(15;17) translocation: a comparative study of RT-PCR cytogenetics, and fluorescence In situ hybridization.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 1999;4(3):195-209.
1999: Michael Murphy; L J Hickman; Christopher B Eckman; Sacha N Uljon; Rong Wang; todd golde
gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length.
The Journal of biological chemistry 1999;274(17):11914-23.
1996: D G Cook; J C Sung; todd golde; K M Felsenstein; Boguslaw S Wojczyk; Rudolph E Tanzi; John Q Trojanowski; Virginia M-Y Lee; Robert W Doms
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9223-8.
1994: T Nakamura; Mikio Shoji; Yasuo Harigaya; M Watanabe; K Hosoda; T T Cheung; L M Shaffer; todd golde; Linda Younkin; Steven G Younkin
Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease.
Annals of neurology 1994;36(6):903-11.
1994: N Suzuki; T T Cheung; X D Cai; A Odaka; L Otvos; Christopher B Eckman; todd golde; Steven G Younkin
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.
Science (New York, N.Y.) 1994;264(5163):1336-40.
1993: A M Wertkin; Raymond Scott Turner; S J Pleasure; todd golde; Steven G Younkin; John Q Trojanowski; Virginia M-Y Lee
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9513-7.
1993: todd golde; X D Cai; M Shoji; Steven G Younkin
Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():103-8.
1993: Rajesh N. Kalaria; todd golde; S N Kroon; George Perry
Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease.
The American journal of pathology 1993;143(3):886-93.
1993: X D Cai; todd golde; Steven G Younkin
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.
Science (New York, N.Y.) 1993;259(5094):514-6.
1992: Steven Estus; todd golde; Steven G Younkin
Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives.
Annals of the New York Academy of Sciences 1992;674():138-48.
1992: Mikio Shoji; todd golde; Jorge Ghiso; T T Cheung; Steven Estus; L M Shaffer; X D Cai; D M McKay; R Tintner; Blas Frangione
Production of the Alzheimer amyloid beta protein by normal proteolytic processing.
Science (New York, N.Y.) 1992;258(5079):126-9.
1992: S L Gillespie; todd golde; Steven G Younkin
Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation.
Biochemical and biophysical research communications 1992;187(3):1285-90.
1992: todd golde; Steven Estus; Linda Younkin; Dennis J Selkoe; Steven G Younkin
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
Science (New York, N.Y.) 1992;255(5045):728-30.
1992: Steven Estus; todd golde; T Kunishita; D Blades; D Lowery; M Eisen; M Usiak; X M Qu; Takeshi Tabira; Barry D Greenberg
Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.
Science (New York, N.Y.) 1992;255(5045):726-8.
1991: Rajesh N. Kalaria; todd golde; M L Cohen; Steven G Younkin
Serum amyloid P in Alzheimer's disease. Implications for dysfunction of the blood-brain barrier.
Annals of the New York Academy of Sciences 1991;640():145-8.
1990: todd golde; Steven Estus; M Usiak; Linda Younkin; Steven G Younkin
Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.
Neuron 1990;4(2):253-67.
1990: M R Palmert; Marcia B Podlisny; todd golde; M L Cohen; Dora M. Kovacs; Rudolph E Tanzi; James Gusella; Peter J Whitehouse; D S Witker; Tilman Oltersdorf
Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products.
Advances in neurology 1990;51():181-4.
1989: M R Palmert; Marcia B Podlisny; todd golde; M L Cohen; Dora M. Kovacs; Rudolph E Tanzi; James Gusella; Peter J Whitehouse; D S Witker; Tilman Oltersdorf
The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives.
Progress in clinical and biological research 1989;317():971-84.
1988: M R Palmert; todd golde; M L Cohen; Dora M. Kovacs; Rudolph E Tanzi; James Gusella; M F Usiak; Linda Younkin; Steven G Younkin
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.
Science (New York, N.Y.) 1988;241(4869):1080-4.
1988: Barbara A Osborne; todd golde; R L Schwartz; S Rudikoff
Evolution of the IgA heavy chain gene in the genus Mus.
Genetics 1988;119(4):925-31.
1988: M L Cohen; todd golde; M F Usiak; Linda Younkin; Steven G Younkin
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1227-31.
1986: Barbara A Osborne; todd golde; R L Schwartz; S Rudikoff
Evolution of the mouse IgA gene: nucleotide sequence comparison of IgA in BALB/c and Mus pahari.
Current topics in microbiology and immunology 1986;127():141-8.