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Robin Carrell

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Aiwu Zhou; Robin W Carrell; Michael P Murphy; Zhenquan Wei; Yahui Yan; Peter L D Stanley; Penelope E Stein; Fiona Broughton Pipkin; Randy J Read
A redox switch in angiotensinogen modulates angiotensin release.
Zhenquan Wei; Yahui Yan; Robin W Carrell; Aiwu Zhou
Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X.
Robin W Carrell; Alec Mushunje; Aiwu Zhou
Serpins show structural basis for oligomer toxicity and amyloid ubiquity.

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2010: Aiwu Zhou; Robin W Carrell; Michael P Murphy; Zhenquan Wei; Yahui Yan; Peter L D Stanley; Penelope E Stein; Fiona Broughton Pipkin; Randy J Read
A redox switch in angiotensinogen modulates angiotensin release.
Nature 2010;468(7320):108-11.
2009: Zhenquan Wei; Yahui Yan; Robin W Carrell; Aiwu Zhou
Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X.
Blood 2009;114(17):3662-7.
2008: Robin W Carrell; Alec Mushunje; Aiwu Zhou
Serpins show structural basis for oligomer toxicity and amyloid ubiquity.
FEBS letters 2008;582(17):2537-41.
2008: Aiwu Zhou; Zhenquan Wei; Peter L D Stanley; Randy J Read; Penelope E Stein; Robin W Carrell
The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release.
Journal of molecular biology 2008;380(1):244-51.
2008: Aiwu Zhou; Robin W Carrell
Dimers initiate and propagate serine protease inhibitor polymerisation.
Journal of molecular biology 2008;375(1):36-42.
2006: Aiwu Zhou; Zhenquan Wei; Randy J Read; Robin W Carrell
Structural mechanism for the carriage and release of thyroxine in the blood.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(36):13321-6.
2005: Robin W Carrell
Cell toxicity and conformational disease.
Trends in cell biology 2005;15(11):574-80.
2005: Javier Corral; Vicente Vicente; Robin W Carrell
Thrombosis as a conformational disease.
Haematologica 2005;90(2):238-46.
2004: Robin W Carrell
Biomedicine. Prion dormancy and disease.
Science (New York, N.Y.) 2004;306(5702):1692-3.
2004: Alec Mushunje; G Evans; Stephen O Brennan; Robin W Carrell; Aiwu Zhou
Latent antithrombin and its detection, formation and turnover in the circulation.
Journal of thrombosis and haemostasis : JTH 2004;2(12):2170-7.
2004: Aiwu Zhou; Penelope E Stein; James A Huntington; Pasupathy Sivasothy; David A Lomas; Robin W Carrell
How small peptides block and reverse serpin polymerisation.
Journal of molecular biology 2004;342(3):931-41.
2004: Javier Corral; Justo Aznar; Rocio Gonzalez-Conejero; Piedad Villa; Antonia Miñano; Amparo Vayá; Robin W Carrell; James A Huntington; Vicente Vicente
Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis.
Circulation 2004;110(10):1303-7.
2004: Javier Corral; James A Huntington; Rocio González-Conejero; Alec Mushunje; M Navarro; Pascual Marco; Vicente Vicente; Robin W Carrell
Mutations in the shutter region of antithrombin result in formation of disulfide-linked dimers and severe venous thrombosis.
Journal of thrombosis and haemostasis : JTH 2004;2(6):931-9.
2004: Robin W Carrell
What we owe to alpha(1)-antitrypsin and to Carl-Bertil Laurell.
COPD 2004;1(1):71-84.
2004: Robin W Carrell; Javier Corral
What can Drosophila tell us about serpins, thrombosis and dementia?
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(1):1-5.
2003: Alec Mushunje; Aiwu Zhou; Robin W Carrell; James A Huntington
Heparin-induced substrate behavior of antithrombin Cambridge II.
Blood 2003;102(12):4028-34.
2003: Noelene S Quinsey; Hazel L Fitton; Paul B Coughlin; James C Whisstock; Timothy R Dafforn; Robin W Carrell; Stephen P Bottomley; Robert N Pike
Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability.
Biochemistry 2003;42(34):10169-73.
2003: Aiwu Zhou; James A Huntington; Neesh Pannu; Robin W Carrell; Randy J Read
How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration.
Nature structural biology 2003;10(7):541-4.
2003: Aiwu Zhou; Penelope E Stein; James A Huntington; Robin W Carrell
Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol.
The Journal of biological chemistry 2003;278(17):15116-22.
2003: Emma C Morris; Timothy R Dafforn; Sharon L Forsyth; Melinda A Missen; Anita J Horvath; Lynne Hampson; Ian N Hampson; Graeme Currie; Robin W Carrell; Paul B Coughlin
Murine serpin 2A is a redox-sensitive intracellular protein.
The Biochemical journal 2003;371(Pt 1):165-73.
2003: Airlie J McCoy; Xue Yuan Pei; Richard Skinner; Jan Pieter Abrahams; Robin W Carrell
Structure of beta-antithrombin and the effect of glycosylation on antithrombin's heparin affinity and activity.
Journal of molecular biology 2003;326(3):823-33.
2003: Robin W Carrell; James A Huntington
How serpins change their fold for better and for worse.
Biochemical Society symposium 2003;(70):163-78.
2002: David A Lomas; Robin W Carrell
Serpinopathies and the conformational dementias.
Nature reviews. Genetics 2002;3(10):759-68.
2002: Alec Mushunje; Aiwu Zhou; James A Huntington; Jacqueline Conard; Robin W Carrell
Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity.
Thrombosis and haemostasis 2002;88(3):436-43.
2002: Trevor P Baglin; Robin W Carrell; Frank Church; Charles T Esmon; James A Huntington
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11079-84.
2002: Richard L Davis; Antony E Shrimpton; Robin W Carrell; David A Lomas; Lieselotte Gerhard; Bruno Baumann; Daniel Lawrence; Manuel Yepes; Tai Seung Kim; Bernardino Ghetti; Pedro Piccardo; Masaki Takao; Felicitas Lacbawan; Maximilian Muenke; Richard N Sifers; Charles B Bradshaw; Paul F Kent; George H Collins; Daria Larocca; Peter D Holohan
Association between conformational mutations in neuroserpin and onset and severity of dementia.
Lancet 2002;359(9325):2242-7.
2002: Klara J Belzar; Aiwu Zhou; Robin W Carrell; Peter G W Gettins; James A Huntington
Helix D elongation and allosteric activation of antithrombin.
The Journal of biological chemistry 2002;277(10):8551-8.
2002: Ravi Mahadeva; Timothy R Dafforn; Robin W Carrell; David A Lomas
6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.
The Journal of biological chemistry 2002;277(9):6771-4.
2002: Robin W Carrell; David A Lomas
Alpha1-antitrypsin deficiency--a model for conformational diseases.
The New England journal of medicine 2002;346(1):45-53.
2001: Emma C Morris; Robin W Carrell; Paul B Coughlin
Intracellular serpins in haemopoietic and peripheral blood cells.
British journal of haematology 2001;115(4):758-66.
2001: Gary A Silverman; Phillip I Bird; Robin W Carrell; Frank Church; Paul B Coughlin; Peter G W Gettins; James Irving; D A Lomas; C J Luke; R W Moyer; Philip A Pemberton; Eileen Remold-O'Donnell; G S Salvesen; J Travis; James C Whisstock
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.
The Journal of biological chemistry 2001;276(36):33293-6.
2001: Aiwu Zhou; Robin W Carrell; James A Huntington
The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop.
The Journal of biological chemistry 2001;276(29):27541-7.
2001: Robin W Carrell; James A Huntington; Alec Mushunje; Aiwu Zhou
The conformational basis of thrombosis.
Thrombosis and haemostasis 2001;86(1):14-22.
2001: Aiwu Zhou; Richard Faint; Peter A Charlton; Timothy R Dafforn; Robin W Carrell; David A Lomas
Polymerization of plasminogen activator inhibitor-1.
The Journal of biological chemistry 2001;276(12):9115-22.
2001: James A Huntington; Robin W Carrell
The serpins: nature's molecular mousetraps.
Science progress 2001;84(Pt 2):125-36.
2000: James A Huntington; Randy J Read; Robin W Carrell
Structure of a serpin-protease complex shows inhibition by deformation.
Nature 2000;407(6806):923-6.
2000: James C Whisstock; Robert N Pike; L Jin; Richard Skinner; Xue Yuan Pei; Robin W Carrell; Arthur M Lesk
Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparindagger.
Journal of molecular biology 2000;301(5):1287-305.
2000: James A Huntington; A McCoy; Klara J Belzar; Xue Yuan Pei; Peter G W Gettins; Robin W Carrell
The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions.
The Journal of biological chemistry 2000;275(20):15377-83.
2000: Klara J Belzar; Timothy R Dafforn; M Petitou; Robin W Carrell; James A Huntington
The effect of a reducing-end extension on pentasaccharide binding by antithrombin.
The Journal of biological chemistry 2000;275(12):8733-41.
2000: James C Whisstock; Richard Skinner; Robin W Carrell; Arthur M Lesk
Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin.
Journal of molecular biology 2000;296(2):685-99.
2000: James C Whisstock; Richard Skinner; Robin W Carrell; Arthur M Lesk
Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin.
Journal of molecular biology 2000;295(3):651-65.
2000: Bibek Gooptu; Bart Hazes; Wun-Shaing W Chang; Timothy R Dafforn; Robin W Carrell; Randy J Read; David A Lomas
Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):67-72.
1999: Aiwu Zhou; James A Huntington; Robin W Carrell
Formation of the antithrombin heterodimer in vivo and the onset of thrombosis.
Blood 1999;94(10):3388-96.
1999: James A Huntington; Neesh Pannu; Bart Hazes; Randy J Read; David A Lomas; Robin W Carrell
A 2.6 A structure of a serpin polymer and implications for conformational disease.
Journal of molecular biology 1999;293(3):449-55.
1999: Richard L Davis; Antony E Shrimpton; Peter D Holohan; C Bradshaw; D Feiglin; George H Collins; Peter Sonderegger; Jochen Kinter; L M Becker; Felicitas Lacbawan; D Krasnewich; Maximilian Muenke; Daniel Lawrence; M S Yerby; C M Shaw; Bibek Gooptu; PR Elliott; J T Finch; Robin W Carrell; David A Lomas
Familial dementia caused by polymerization of mutant neuroserpin.
Nature 1999;401(6751):376-9.
1999: Robin W Carrell
How serpins are shaping up.
Science (New York, N.Y.) 1999;285(5435):1861.
1999: A M Sharp; Penelope E Stein; Neesh Pannu; Robin W Carrell; M B Berkenpas; David Ginsburg; Daniel Lawrence; Randy J Read
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion.
Structure (London, England : 1993) 1999;7(2):111-8.
1998: Robin W Carrell; Bibek Gooptu
Conformational changes and disease--serpins, prions and Alzheimer's.
Current opinion in structural biology 1998;8(6):799-809.
1998: Nicholas J Beauchamp; Robert N Pike; M Daly; L Butler; Michael Makris; Timothy R Dafforn; A Zhou; Hazel L Fitton; F Eric Preston; Ian R Peake; Robin W Carrell
Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation.
Blood 1998;92(8):2696-706.
1998: R M Streatfeild-James; D Williamson; Robert N Pike; D Tewksbury; Robin W Carrell; Paul B Coughlin
Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus.
FEBS letters 1998;436(2):267-70.
1998: Richard Skinner; Wun-Shaing W Chang; L Jin; X Pei; James A Huntington; Jan Pieter Abrahams; Robin W Carrell; David A Lomas
Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
Journal of molecular biology 1998;283(1):9-14.
1997: L Jin; Jan Pieter Abrahams; Richard Skinner; M Petitou; Robert N Pike; Robin W Carrell
The anticoagulant activation of antithrombin by heparin.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14683-8.
1997: Mark Wardell; Wun-Shaing W Chang; D Bruce; Richard Skinner; Arthur M Lesk; Robin W Carrell
Preparative induction and characterization of L-antithrombin: a structural homologue of latent plasminogen activator inhibitor-1.
Biochemistry 1997;36(42):13133-42.
1997: Hazel L Fitton; Robert N Pike; Robin W Carrell; Wun-Shaing W Chang
Mechanisms of antithrombin polymerisation and heparin activation probed by the insertion of synthetic reactive loop peptides.
Biological chemistry 1997;378(9):1059-63.
1997: Robert N Pike; Jan Potempa; Richard Skinner; Hazel L Fitton; W T McGraw; J Travis; M Owen; L Jin; Robin W Carrell
Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity.
The Journal of biological chemistry 1997;272(32):19652-5.
1997: Robin W Carrell; David A Lomas
Conformational disease.
Lancet 1997;350(9071):134-8.
1997: Robin W Carrell; Richard Skinner; L Jin; Jan Pieter Abrahams
Structural mobility of antithrombin and its modulation by heparin.
Thrombosis and haemostasis 1997;78(1):516-9.
1997: Hazel L Fitton; I D Walker; L Jones; K Brown; Robin W Carrell; Paul B Coughlin
Five antithrombin variants, four associated with thrombosis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1997;8(2):145-8.
1997: David A Lomas; PR Elliott; Robin W Carrell
Commercial plasma alpha1-antitrypsin (Prolastin) contains a conformationally inactive, latent component.
The European respiratory journal 1997;10(3):672-5.
1997: Richard Skinner; Jan Pieter Abrahams; James C Whisstock; Arthur M Lesk; Robin W Carrell; Mark Wardell
The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
Journal of molecular biology 1997;266(3):601-9.
1997: Robin W Carrell; David Lomas; P Stein; James C Whisstock
Dysfunctional variants and the structural biology of the serpins.
Advances in experimental medicine and biology 1997;425():207-22.
1997: Wun-Shaing W Chang; James C Whisstock; Paul C R Hopkins; Arthur M Lesk; Robin W Carrell; Mark Wardell
Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins.
Protein science : a publication of the Protein Society 1997;6(1):89-98.
1996: Robin W Carrell; David A Lomas; S Sidhar; R Foreman
Alpha 1-antitrypsin deficiency. A conformational disease.
Chest 1996;110(6 Suppl):243S-247S.
1996: James C Whisstock; Arthur M Lesk; Robin W Carrell
Modeling of serpin-protease complexes: antithrombin-thrombin, alpha 1-antitrypsin (358Met-->Arg)-thrombin, alpha 1-antitrypsin (358Met-->Arg)-trypsin, and antitrypsin-elastase.
Proteins 1996;26(3):288-303.
1996: PR Elliott; P E Stein; Diana Bilton; Robin W Carrell; David A Lomas
Structural explanation for the deficiency of S alpha 1-antitrypsin.
Nature structural biology 1996;3(11):910-1.
1996: PR Elliott; David A Lomas; Robin W Carrell; Jan Pieter Abrahams
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
Nature structural biology 1996;3(8):676-81.
1996: Robin W Carrell; David J Perry
Annotation. The unhinged antithrombins.
British journal of haematology 1996;93(2):253-7.
1996: M Daly; David J Perry; D B Bruce; P L Harper; R Campbell Tait; Isobel D Walker; E E Mayne; H M Daly; K Brown; Robin W Carrell
Type I antithrombin deficiency: five novel mutations associated with thrombosis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1996;7(2):139-43.
1996: P L Harper; G R Park; Robin W Carrell
The plasma turnover of transfused antithrombin concentrate in patients with acquired antithrombin deficiency.
Transfusion medicine (Oxford, England) 1996;6(1):45-50.
1996: Wun-Shaing W Chang; Mark Wardell; David A Lomas; Robin W Carrell
Probing serpin reactive-loop conformations by proteolytic cleavage.
The Biochemical journal 1996;314 ( Pt 2)():647-53.
1996: Robin W Carrell; P E Stein
The biostructural pathology of the serpins: critical function of sheet opening mechanism.
Biological chemistry Hoppe-Seyler 1996;377(1):1-17.
1995: David J Perry; Martina E Daly; B T Colvin; K Brown; Robin W Carrell
Two antithrombin mutations in a compound heterozygote: Met20Thr and Tyr166Cys.
American journal of hematology 1995;50(3):215-6.
1995: David A Lomas; SR Stone; C Llewellyn-Jones; M T Keogan; Z M Wang; H Rubin; Robin W Carrell; Robert A Stockley
The control of neutrophil chemotaxis by inhibitors of cathepsin G and chymotrypsin.
The Journal of biological chemistry 1995;270(40):23437-43.
1995: David A Lomas; PR Elliott; S K Sidhar; R C Foreman; J T Finch; D W Cox; James C Whisstock; Robin W Carrell
alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.
The Journal of biological chemistry 1995;270(28):16864-70.
1995: Paul C R Hopkins; D C Crowther; Robin W Carrell; SR Stone
Development of a novel recombinant serpin with potential antithrombotic properties.
The Journal of biological chemistry 1995;270(20):11866-71.
1995: S K Sidhar; David A Lomas; Robin W Carrell; R C Foreman
Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants.
The Journal of biological chemistry 1995;270(15):8393-6.
1995: David A Lomas; PR Elliott; Wun-Shaing W Chang; Mark Wardell; Robin W Carrell
Preparation and characterization of latent alpha 1-antitrypsin.
The Journal of biological chemistry 1995;270(10):5282-8.
1995: David J Perry; C Marshall; J Y Borg; R Campbell Tait; Martina E Daly; Isobel D Walker; Robin W Carrell
Two novel antithrombin variants, Asn187Asp and Asn187Lys, indicate a functional role for asparagine 187.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1995;6(1):51-4.
1995: P E Stein; Robin W Carrell
What do dysfunctional serpins tell us about molecular mobility and disease?
Nature structural biology 1995;2(2):96-113.
1994: D Bruce; David J Perry; J Y Borg; Robin W Carrell; Mark Wardell
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)
The Journal of clinical investigation 1994;94(6):2265-74.
1994: Robin W Carrell; James C Whisstock; David A Lomas
Conformational changes in serpins and the mechanism of alpha 1-antitrypsin deficiency.
American journal of respiratory and critical care medicine 1994;150(6 Pt 2):S171-5.
1994: C G Llewellyn-Jones; David A Lomas; Robin W Carrell; Robert A Stockley
The effect of the Z mutation on the ability of alpha 1-antitrypsin to prevent neutrophil mediated tissue damage.
Biochimica et biophysica acta 1994;1227(3):155-60.
1994: R Campbell Tait; Isobel D Walker; David J Perry; S I Islam; Martina E Daly; F McCall; JA Conkie; Robin W Carrell
Prevalence of antithrombin deficiency in the healthy population.
British journal of haematology 1994;87(1):106-12.
1994: Robin W Carrell; P E Stein; G Fermi; Mark Wardell
Biological implications of a 3 A structure of dimeric antithrombin.
Structure (London, England : 1993) 1994;2(4):257-70.
1993: David A Lomas; Robin W Carrell
A protein structural approach to the solution of biological problems: alpha 1-antitrypsin as a recent example.
The American journal of physiology 1993;265(3 Pt 1):L211-9.
1993: Paul C R Hopkins; Robin W Carrell; SR Stone
Effects of mutations in the hinge region of serpins.
Biochemistry 1993;32(30):7650-7.
1993: David A Lomas; J T Finch; K Seyama; T Nukiwa; Robin W Carrell
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization.
The Journal of biological chemistry 1993;268(21):15333-5.
1993: David A Lomas; D L Evans; SR Stone; Wun-Shaing W Chang; Robin W Carrell
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin.
Biochemistry 1993;32(2):500-8.
1993: David A Lomas; D L Evans; C Upton; G McFadden; Robin W Carrell
Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor.
The Journal of biological chemistry 1993;268(1):516-21.
1992: D L Evans; C J Marshall; P B Christey; Robin W Carrell
Heparin binding site, conformational change, and activation of antithrombin.
Biochemistry 1992;31(50):12629-42.
1992: D C Crowther; D L Evans; Robin W Carrell
Serpins: implications of a mobile reactive centre.
Current opinion in biotechnology 1992;3(4):399-407.
1992: P L Harper; J M Hermans; Robin W Carrell
Recombinant natural anticoagulants: a review.
Journal of the Royal Society of Medicine 1992;85(7):407-11.
1992: David A Lomas; D L Evans; J T Finch; Robin W Carrell
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
Nature 1992;357(6379):605-7.
1992: M Daly; David J Perry; P L Harper; H M Daly; A W Roques; Robin W Carrell
Insertions/deletions in the antithrombin gene: 3 mutations associated with non-expression.
Thrombosis and haemostasis 1992;67(5):521-5.
1991: D L Evans; M McGrogan; R W Scott; Robin W Carrell
Protease specificity and heparin binding and activation of recombinant protease nexin I.
The Journal of biological chemistry 1991;266(33):22307-12.
1991: Robin W Carrell; D L Evans; P E Stein
Mobile reactive centre of serpins and the control of thrombosis.
Nature 1991;353(6344):576-8.
1991: P E Stein; Andrew G W Leslie; J T Finch; Robin W Carrell
Crystal structure of uncleaved ovalbumin at 1.95 A resolution.
Journal of molecular biology 1991;221(3):941-59.
1991: David J Perry; M Daly; P L Harper; R Campbell Tait; J Price; Isobel D Walker; Robin W Carrell
Antithrombin Cambridge II, 384 Ala to Ser. Further evidence of the role of the reactive centre loop in the inhibitory function of the serpins.
FEBS letters 1991;285(2):248-50.
1991: P L Harper; L Williamson; G Park; J K Smith; Robin W Carrell
A pilot study of antithrombin replacement in intensive care management: the effects on mortality, coagulation and renal function.
Transfusion medicine (Oxford, England) 1991;1(2):121-8.
1991: A Avron; F H Reeve; J M Lickorish; Robin W Carrell
Effect of alanine insertion (P'5) on the reactive centre of alpha 1-antitrypsin.
FEBS letters 1991;280(1):41-3.
1991: P L Harper; Roger Luddington; M Daly; D Bruce; D Williamson; P F Edgar; David J Perry; Robin W Carrell
The incidence of dysfunctional antithrombin variants: four cases in 210 patients with thromboembolic disease.
British journal of haematology 1991;77(3):360-4.
1990: M Daly; D Bruce; David J Perry; J Price; P L Harper; A O'Meara; Robin W Carrell
Antithrombin Dublin (-3 Val----Glu): an N-terminal variant which has an aberrant signal peptidase cleavage site.
FEBS letters 1990;273(1-2):87-90.
1990: P E Stein; Andrew G W Leslie; J T Finch; W G Turnell; P J McLaughlin; Robin W Carrell
Crystal structure of ovalbumin as a model for the reactive centre of serpins.
Nature 1990;347(6288):99-102.
1989: P L Harper; Roger Luddington; I Jennings; D Reardon; M J Seaman; Robin W Carrell; J R Klink; M Smith; K Rolles; Roy Y Calne
Coagulation changes following hepatic revascularization during liver transplantation.
Transplantation 1989;48(4):603-7.
1989: David J Perry; P L Harper; S Fairham; M Daly; Robin W Carrell
Antithrombin Cambridge, 384 Ala to Pro: a new variant identified using the polymerase chain reaction.
FEBS letters 1989;254(1-2):174-6.
1989: P E Stein; D A Tewkesbury; Robin W Carrell
Ovalbumin and angiotensinogen lack serpin S-R conformational change.
The Biochemical journal 1989;262(1):103-7.
1989: David J Perry; Robin W Carrell
CpG dinucleotides are "hotspots" for mutation in the antithrombin III gene. Twelve variants identified using the polymerase chain reaction.
Molecular biology & medicine 1989;6(3):239-43.
1989: J V Langdown; D Williamson; C B Knight; D Rubenstein; Robin W Carrell
A new doubly substituted sickling haemoglobin: HbS-Oman.
British journal of haematology 1989;71(3):443-4.
1989: P A Pemberton; R A Harrison; Peter Lachmann; Robin W Carrell
The structural basis for neutrophil inactivation of C1 inhibitor.
The Biochemical journal 1989;258(1):193-8.
1989: Robin W Carrell; K S Aulak; M C Owen
The molecular pathology of the serpins.
Molecular biology & medicine 1989;6(1):35-42.
1988: P A Pemberton; P E Stein; M B Pepys; J M Potter; Robin W Carrell
Hormone binding globulins undergo serpin conformational change in inflammation.
Nature 1988;336(6196):257-8.
1988: P L Harper; P F Edgar; Roger Luddington; M J Seaman; Robin W Carrell; A T Salt; N Barnes; K Rolles; Roy Y Calne
Protein C deficiency and portal thrombosis in liver transplantation in children.
Lancet 1988;2(8617):924-7.