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Akiko Horiuchi

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Tumor Cells, Cultured

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Chiho Fuseya; Akiko Hayashi; Takuma Hayashi; Akiko Horiuchi; Tsutomu Miyamoto; Akihisa Suzuki; Tanri Shiozawa
Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis.
Akiko Horiuchi; Norihiko Kikuchi; Chiho Fuseya; Akiko Hayashi; Takuma Hayashi; Tanri Shiozawa; Ikuo Konishi
Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene.
Takuma Hayashi; Nobuyoshi Hiraoka; Akiko Horiuchi; Tomoyuki Ichimura; Osamu Ishiko; Yae Kanai; Mari Kasai; Ryuichiro Nishimura; Kenji Sano; Tanri Shiozawa; Tamotsu Sudo; Nobuo Yaegashi; Hiroyuki Aburatani; Ikuo Konishi
Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1.

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2012: Chiho Fuseya; Akiko Hayashi; Takuma Hayashi; Akiko Horiuchi; Tsutomu Miyamoto; Akihisa Suzuki; Tanri Shiozawa
Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis.
Human pathology 2012;43(11):1964-72.
2012: Akiko Horiuchi; Norihiko Kikuchi; Chiho Fuseya; Akiko Hayashi; Takuma Hayashi; Tanri Shiozawa; Ikuo Konishi
Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene.
International journal of cancer. Journal international du cancer 2012;131(8):1755-67.
2012: Takuma Hayashi; Nobuyoshi Hiraoka; Akiko Horiuchi; Tomoyuki Ichimura; Osamu Ishiko; Yae Kanai; Mari Kasai; Ryuichiro Nishimura; Kenji Sano; Tanri Shiozawa; Tamotsu Sudo; Nobuo Yaegashi; Hiroyuki Aburatani; Ikuo Konishi
Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1.
FEBS letters 2012;586(13):1824-31.
2012: Yuko Mitsuhashi; Tsutomu Miyamoto; Akiko Horiuchi; Hiroyasu Kashima; Akihisa Suzuki; Tanri Shiozawa
Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells.
Histopathology 2012;60(5):826-37.
2011: Takuma Hayashi; Nobuyoshi Hiraoka; Akiko Horiuchi; Tomoyuki Ichimura; Osamu Ishiko; Yae Kanai; Mari Kasai; Satoru Nagase; Kenji Sano; Tanri Shiozawa; Susumu Tonegawa; Nobuo Yaegashi; Hiroyuki Aburatani; Ikuo Konishi
Involvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma.
North American journal of medical sciences 2011;3(9):394-9.
2011: Takako Okamoto; Noriomi Matsumura; Michiko Mandai; Tomonori Oura; Yukio Yamanishi; Akiko Horiuchi; Junzo Hamanishi; Tsukasa Baba; Masafumi Koshiyama; Tanri Shiozawa; Ikuo Konishi
Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011;24(2):267-76.
2011: Takuma Hayashi; Akiko Horiuchi; Kenji Sano; Nobuyoshi Hiraoka; Yae Kanai; Tanri Shiozawa; Susumu Tonegawa; Ikuo Konishi
Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma.
Sarcoma 2011;2011():476498.
2010: Kaoru Abiko; Michiko Mandai; Junzo Hamanishi; Noriomi Matsumura; Tsukasa Baba; Akiko Horiuchi; Yoshiki Mikami; Shinya Yoshioka; Tomoko Wakasa; Tanri Shiozawa; Ikuo Konishi
Oct4 expression in immature teratoma of the ovary: relevance to histologic grade and degree of differentiation.
The American journal of surgical pathology 2010;34(12):1842-8.
2010: Akiko Hayashi; Akiko Horiuchi; Norihiko Kikuchi; Takuma Hayashi; Chiho Fuseya; Akihisa Suzuki; Ikuo Konishi; Tanri Shiozawa
Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin.
International journal of cancer. Journal international du cancer 2010;127(6):1332-46.
2010: Akihisa Suzuki; Akiko Horiuchi; Takashi Ashida; Tsutomu Miyamoto; Hiroyasu Kashima; Toshio Nikaido; Ikuo Konishi; Tanri Shiozawa
Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin.
Journal of cellular and molecular medicine 2010;14(9):2305-17.
2010: Takuma Hayashi; Akiko Horiuchi; Kenji Sano; Nobuyoshi Hiraoka; Yae Kanai; Tanri Shiozawa; Susumu Tonegawa; Ikuo Konishi
Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma.
Protein & cell 2010;1(8):711-7.
2010: Akihisa Suzuki; Akiko Horiuchi; Kenji Oka; Tsutomu Miyamoto; Hiroyasu Kashima; Tanri Shiozawa
Immunohistochemical detection of steroid receptor cofactors in ovarian endometriosis: involvement of down-regulated SRC-1 expression in the limited growth activity of the endometriotic epithelium.
Virchows Archiv : an international journal of pathology 2010;456(4):433-41.
2010: Tsutomu Miyamoto; Akiko Horiuchi; Hiroyasu Kashima; Akihisa Suzuki; Tomoko Yamada; Miyuki Kurai; Ikuo Konishi; Tanri Shiozawa
Inverse correlation between Skp2 and p27(Kip1) in normal endometrium and endometrial carcinoma.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2010;26(3):220-9.
2009: Junko Yoshida; Akiko Horiuchi; Norihiko Kikuchi; Akiko Hayashi; Ryosuke Osada; Satoshi Ohira; Tanri Shiozawa; Ikuo Konishi
Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression.
Medical molecular morphology 2009;42(2):82-91.
2009: Hiroyasu Kashima; Akiko Horiuchi; Junko Uchikawa; Tsutomu Miyamoto; Akihisa Suzuki; Takashi Ashida; Ikuo Konishi; Tanri Shiozawa
Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma.
Anticancer research 2009;29(4):1023-9.
2008: Akiko Horiuchi; Norihiko Kikuchi; Ryosuke Osada; Cuiju Wang; Akiko Hayashi; Toshio Nikaido; Ikuo Konishi
Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer.
Cancer science 2008;99(12):2532-9.
2008: Takuma Hayashi; Yuto Shimamura; Taro Saegusa; Akiko Horiuchi; Yukihiro Kobayashi; Nobuyoshi Hiraoka; Yae Kanai; Hiroyuki Aburatani; Kenji Sano; Ikuo Konishi
Molecular mechanisms of uterine leiomyosarcomas: involvement of defect in LMP2 expression.
Gene regulation and systems biology 2008;2():297-305.
2007: Ryosuke Osada; Akiko Horiuchi; Norihiko Kikuchi; Junko Yoshida; Akiko Hayashi; Masao Ota; Yoshihiko Katsuyama; Giovanni Melillo; Giovanni Mellilo; Ikuo Konishi
Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma.
Human pathology 2007;38(9):1310-20.
2007: Akiko Horiuchi; Cuiju Wang; Norihiko Kikuchi; Ryosuke Osada; Toshio Nikaido; Ikuo Konishi
BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells.
Biomarker insights 2007;1():49-59.
2007: Xiaojun Chen; Akiko Horiuchi; Norihiko Kikuchi; Ryosuke Osada; Junko Yoshida; Tanri Shiozawa; Ikuo Konishi
Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis.
Cancer science 2007;98(1):68-76.
2006: Ryosuke Osada; Akiko Horiuchi; Norihiko Kikuchi; Satoshi Ohira; Masao Ota; Yoshihiko Katsuyama; Ikuo Konishi
Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas.
Human pathology 2006;37(11):1414-25.
2006: Norihiko Kikuchi; Akiko Horiuchi; Ryosuke Osada; Tsutomu Imai; Cuiju Wang; Xiaojun Chen; Ikuo Konishi
Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: an important autocrine/paracrine factor in tumor progression.
Cancer science 2006;97(10):1061-9.
2005: Yu-Zhen Feng; Tanri Shiozawa; Akiko Horiuchi; Hsien-Chang Shih; Tsutomu Miyamoto; Hiroyasu Kashima; Akihisa Suzuki; Toshio Nikaido; Ikuo Konishi
Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas.
Virchows Archiv : an international journal of pathology 2005;447(5):816-22.
2004: Tsutomu Imai; Akiko Horiuchi; Tanri Shiozawa; Ryosuke Osada; Norihiko Kikuchi; Satoshi Ohira; Kenji Oka; Ikuo Konishi
Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas.
Human pathology 2004;35(12):1469-76.
2004: Akiko Horiuchi; Ikuo Konishi
[Prevention of ovarian cancer development].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 10():597-600.
2004: Akiko Horiuchi; Ikuo Konishi
[Mechanism of ovarian cancer metastasis--changes in E-cadherin expression].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 10():463-6.
2004: Satoshi Ohira; Kazuko Itoh; Tanri Shiozawa; Akiko Horiuchi; Kyoko Ono; Haruka Takeuchi; Waki Hosoda; Ikuo Konishi
Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone-related hypercalcemia.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2004;23(4):393-7.
2004: Cuiju Wang; Akiko Horiuchi; Tsutomu Imai; Satoshi Ohira; Kazuko Itoh; Toshio Nikaido; Yoshihiko Katsuyama; Ikuo Konishi
Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene.
The Journal of pathology 2004;202(2):215-23.
2004: Kiyoshi Kato; Tanri Shiozawa; Junji Mitsushita; Ayaka Toda; Akiko Horiuchi; Toshio Nikaido; Shingo Fujii; Ikuo Konishi
Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas.
Human pathology 2004;35(1):55-60.
2003: Tsutomu Imai; Akiko Horiuchi; Cuiju Wang; Kenji Oka; Satoshi Ohira; Toshio Nikaido; Ikuo Konishi
Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells.
The American journal of pathology 2003;163(4):1437-47.
2003: Akiko Horiuchi; Tsutomu Imai; Cuiju Wang; Satoshi Ohira; Yuzhen Feng; Toshio Nikaido; Ikuo Konishi
Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2003;83(6):861-70.
2003: Akiko Horiuchi; Kazuko Itoh; Motohiko Shimizu; Ikuko Nakai; Teruyuki Yamazaki; Kaoru Kimura; Akihiko Suzuki; Isao Shiozawa; Noritane Ueda; Ikuo Konishi
Toward understanding the natural history of ovarian carcinoma development: a clinicopathological approach.
Gynecologic oncology 2003;88(3):309-17.
2003: Tominaga Shimizu; Toshio Nikaido; Hiroki Gomyo; Yasuo Yoshimura; Akiko Horiuchi; Kenichi Isobe; Sohei Ebara; Kunio Takaoka
Electrochemotherapy for digital chondrosarcoma.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2003;8(2):248-51.
2002: Akiko Horiuchi; Tsutomu Imai; Motohiko Shimizu; Kenji Oka; Cuiju Wang; Toshio Nikaido; Ikuo Konishi
Hypoxia-induced changes in the expression of VEGF, HIF-1 alpha and cell cycle-related molecules in ovarian cancer cells.
Anticancer research 2002;22(5):2697-702.
2002: Tanri Shiozawa; Kazuko Itoh; Akiko Horiuchi; Ikuo Konishi; Shingo Fujii; Toshio Nikaido
Down-regulation of estrogen receptor by the methylation of the estrogen receptor gene in endometrial carcinoma.
Anticancer research 2002;22(1A):139-43.
2001: Tanri Shiozawa; Akiko Horiuchi; K Kato; M Obinata; Ikuo Konishi; Shingo Fujii; Toshio Nikaido
Up-regulation of p27Kip1 by progestins is involved in the growth suppression of the normal and malignant human endometrial glandular cells.
Endocrinology 2001;142(10):4182-8.
2001: K Nakayama; Toshihiko Toki; Yali Zhai; X Lu; Akiko Horiuchi; Toshio Nikaido; Ikuo Konishi; Shingo Fujii
Demonstration of focal p53 expression without genetic alterations in endometriotic lesions.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2001;20(3):227-31.
2000: Akiko Horiuchi; Toshio Nikaido; Junji Mitsushita; Toshihiko Toki; Ikuo Konishi; Shingo Fujii
Enhancement of antitumor effect of bleomycin by low-voltage in vivo electroporation: a study of human uterine leiomyosarcomas in nude mice.
International journal of cancer. Journal international du cancer 2000;88(4):640-4.
2000: Akiko Horiuchi; Toshio Nikaido; T Yoshizawa; K Itoh; Y Kobayashi; Toshihiko Toki; Ikuo Konishi; Shingo Fujii
HCG promotes proliferation of uterine leiomyomal cells more strongly than that of myometrial smooth muscle cells in vitro.
Molecular human reproduction 2000;6(6):523-8.
1999: Yali Zhai; Toshio Nikaido; Ayaka Orii; Akiko Horiuchi; Toshihiko Toki; Shingo Fujii
Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma.
Gynecologic oncology 1999;75(3):453-9.
1999: Akiko Horiuchi; Toshio Nikaido; S Taniguchi; Shingo Fujii
Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma.
Journal of the National Cancer Institute 1999;91(9):790-6.
1999: Toshihiko Toki; Akiko Horiuchi; N Ichikawa; A Mori; Toshio Nikaido; Shingo Fujii
Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation.
Molecular human reproduction 1999;5(3):246-51.
1999: Akiko Horiuchi; Toshio Nikaido; Z Ya-Li; Ken-ichi Ito; Ayaka Orii; Shingo Fujii
Heparin inhibits proliferation of myometrial and leiomyomal smooth muscle cells through the induction of alpha-smooth muscle actin, calponin h1 and p27.
Molecular human reproduction 1999;5(2):139-45.
1998: Akiko Horiuchi; R Osada; K Nakayama; T Toki; T Nikaido; S Fujii
Ovarian yolk sac tumor with endometrioid carcinoma arising from endometriosis in a postmenopausal woman, with special reference to expression of alpha-fetoprotein, sex steroid receptors, and p53.
Gynecologic oncology 1998;70(2):295-9.
1998: Akiko Horiuchi; Toshio Nikaido; Ken-ichi Ito; Yali Zhai; Ayaka Orii; S Taniguchi; Toshihiko Toki; Shingo Fujii
Reduced expression of calponin h1 in leiomyosarcoma of the uterus.
Laboratory investigation; a journal of technical methods and pathology 1998;78(7):839-46.
1997: Y Kobayashi; Yali Zhai; M Iinuma; Akiko Horiuchi; Toshio Nikaido; Shingo Fujii
Effects of a GnRH analogue on human smooth muscle cells cultured from normal myometrial and from uterine leiomyomal tissues.
Molecular human reproduction 1997;3(2):91-9.
1996: Toshihiko Toki; Akiko Horiuchi; S F Li; K Nakayama; Steven G Silverberg; Shingo Fujii
Proliferative activity of postmenopausal endometriosis: a histopathologic and immunocytochemical study.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1996;15(1):45-53.
1995: O Oguchi; A Mori; Y Kobayashi; Akiko Horiuchi; Toshio Nikaido; S Fujii
Prediction of histopathologic features and proliferative activity of uterine leiomyoma by magnetic resonance imaging prior to GnRH analogue therapy: correlation between T2-weighted images and effect of GnRH analogue.
Journal of obstetrics and gynaecology (Tokyo, Japan) 1995;21(2):107-17.