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Serge Muyldermans

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Ibrahim Habib; Gholamreza Hassanzadeh Ghassabeh; Claude Hattab; Syria Laperche; Caroline Le-Van-Kim; Serge Muyldermans; Sandrine Sagan; Dorota Smolarek; Kazimiera Wasniowska; Yves Colin Aronovicz; Stephane Gangnard; Magdalena Grodecka; Carlos Gutiérrez; Olivier Bertrand
VHH (nanobody) directed against human glycophorin A: A tool for autologous red cell agglutination assays.
Ningning Song; Liesbeth van Oeffelen; Serge Muyldermans; Trong Nguyen Duc; Eveline Peeters; Daniel Charlier
Expanded target and cofactor repertoire for the transcriptional activator LysM from Sulfolobus.
Trong Nguyen-Duc; Eveline Peeters; Daniel Charlier; Serge Muyldermans; Gholamreza Hassanzadeh Ghassabeh
Nanobody(R)-based chromatin immunoprecipitation/micro-array analysis for genome-wide identification of transcription factor DNA binding sites.

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2013: Ibrahim Habib; Gholamreza Hassanzadeh Ghassabeh; Claude Hattab; Syria Laperche; Caroline Le-Van-Kim; Serge Muyldermans; Sandrine Sagan; Dorota Smolarek; Kazimiera Wasniowska; Yves Colin Aronovicz; Stephane Gangnard; Magdalena Grodecka; Carlos Gutiérrez; Olivier Bertrand
VHH (nanobody) directed against human glycophorin A: A tool for autologous red cell agglutination assays.
Analytical biochemistry 2013;438(1):82-9.
2013: Ningning Song; Liesbeth van Oeffelen; Serge Muyldermans; Trong Nguyen Duc; Eveline Peeters; Daniel Charlier
Expanded target and cofactor repertoire for the transcriptional activator LysM from Sulfolobus.
Nucleic acids research 2013;41(5):2932-49.
2013: Trong Nguyen-Duc; Eveline Peeters; Daniel Charlier; Serge Muyldermans; Gholamreza Hassanzadeh Ghassabeh
Nanobody(R)-based chromatin immunoprecipitation/micro-array analysis for genome-wide identification of transcription factor DNA binding sites.
Nucleic acids research 2013;41(5):e59.
2013: Filippa Fleetwood; Nick Devoogdt; Serge Muyldermans; Mireille Pellis; Stefan Ståhl; Ulrich Wernery; John Löfblom
Surface display of a single-domain antibody library on Gram-positive bacteria.
Cellular and molecular life sciences : CMLS 2013;70(6):1081-93.
2013: Mahdi Behdani; Mahdi Habibi-Anbouhi; Gholamreza Hassanzadeh Ghassabeh; Morteza Karimipour; Hossein Khanahmad; Reza Moazami-Godarzi; Azam Aslemarz; Farzad Baniahmad; Steve Schoonooghe; Negar Seyed; Sirous Zeinali; Serge Muyldermans
Development of VEGFR2-specific Nanobody Pseudomonas exotoxin A conjugated to provide efficient inhibition of tumor cell growth.
New biotechnology 2013;30(2):205-9.
2013: Paraschiv Gabriela; Paulina Czaplewska; Marilena Manea; Serge Muyldermans; Cécile Vincke; Michael Przybylski
Epitope structure and binding affinity of single chain llama anti-β-amyloid antibodies revealed by proteolytic excision affinity-mass spectrometry.
Journal of molecular recognition : JMR 2013;26(1):1-9.
2013: John E Butler; J K Lunney; X-Z Sun; Nancy Wertz; Serge Muyldermans
Resolution of an immunodiagnostic dilemma: heavy chain chimeric antibodies for species in which plasmocytomas are unknown.
Molecular immunology 2013;53(1-2):140-8.
2012: Jingjing Zhu; Guido David; Jeroen Declercq; Gholamreza H Ghassabeh; Jörg Kinne; Iris Lindberg; Sandra M P Meulemans; Serge Muyldermans; Bart Roucourt; Wim J M Van De Ven; Alphons J M Vermorken; John W M Creemers
Generation and characterization of non-competitive furin-inhibiting nanobodies.
The Biochemical journal 2012;448(1):73-82.
2012: Issam Hmila; Serge Muyldermans; Bram Roosens; Hayfa Tounsi; Rahma Ben Abderrazek; Samir Boubaker; Balkiss Bouhaouala-Zahar; Vicky Caveliers; Bernard Cosyns; Mohamed El Ayeb; Tony Lahoutte
Pre-clinical studies of toxin-specific nanobodies: evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming.
Toxicology and applied pharmacology 2012;264(2):222-31.
2012: Mireille Pellis; Ulrich Rothbauer; Cécile Vincke; Kourosh Zolghadr; Inge Dierynck; Kurt Hertogs; Jörg Kinne; Heinrich Leonhardt; Joris Messens; Serge Muyldermans; Els Pardon; Katja Conrath
A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies.
Archives of biochemistry and biophysics 2012;526(2):114-23.
2012: Guy Caljon; Vicky Caveliers; Patrick De Baetselier; Gholamreza Hassanzadeh Ghassabeh; T Lahoutte; Stefan Magez; Y Michotte; Serge Muyldermans; I Smolders; Benoit Stijlemans; Jan Van Den Abbeele; Ralph Clinckers
Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier.
British journal of pharmacology 2012;165(7):2341-53.
2012: Alexis Broisat; Vicky Caveliers; Jens De Vos; Mitra Ahmadi; Daniel Fagret; Catherine Ghezzi; Sophie Hernot; Tony Lahoutte; Sandrine Martin; Serge Muyldermans; Laurent M Riou; Nicole THIELENS; Jakub Toczek; Ulrich Wernery; Nick Devoogdt
Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions.
Circulation research 2012;110(7):927-37.
2012: Sophie Hernot; Alexander L Klibanov; Tony Lahoutte; Serge Muyldermans; Talent Shevchenko; Jakub Toczek; Sunil Unnikrishnan; Alexis Broisat; Vicky Caveliers; Bernard Cosyns; Zhongmin Du; Nick Devoogdt
Nanobody-coupled microbubbles as novel molecular tracer.
Journal of controlled release : official journal of the Controlled Release Society 2012;158(2):346-53.
2012: Matthias D'Huyvetter; Marlies Gijs; Nathalie Impens; An Aerts; Sarah Baatout; Vicky Caveliers; Nick Devoogdt; Serge Muyldermans; Bernard Ponsard; Ilse Vaneycken; Catarina Xavier; Tony Lahoutte
Development of 177Lu-nanobodies for radioimmunotherapy of HER2-positive breast cancer: evaluation of different bifunctional chelators.
Contrast media & molecular imaging 2012;7(2):254-64.
2012: Mahdi Behdani; Mahdi Habibi Anbouhi; Gholamreza Hassanzadeh Ghassabeh; Morteza Karimipour; Alireza Khabiri; Hossein Khanahmad; Nader Asadzadeh; Keyhan Azadmanesh; Steve Schoonooghe; Sirous Zeinali; Serge Muyldermans
Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor.
Molecular immunology 2012;50(1-2):35-41.
2012: Jochen Govaert; Serge Muyldermans; Mireille Pellis; Katja Conrath; Nick Deschacht; Cécile Vincke; Dirk Saerens
Dual beneficial effect of interloop disulfide bond for single domain antibody fragments.
The Journal of biological chemistry 2012;287(3):1970-9.
2012: Guy Caljon; Stefan Magez; Serge Muyldermans; Dirk Saerens; Benoit Stijlemans; Jan Van Den Abbeele; Patrick De Baetselier
Affinity is an important determinant of the anti-trypanosome activity of nanobodies.
PLoS neglected tropical diseases 2012;6(11):e1902.
2012: Cécile Vincke; Ulrich Wernery; Nick Devoogdt; Carlos Gutiérrez; Gholamreza Hassanzadeh Ghassabeh; Serge Muyldermans
Generation of single domain antibody fragments derived from camelids and generation of manifold constructs.
Methods in molecular biology (Clifton, N.J.) 2012;907():145-76.
2012: Trong Nguyen Duc; Gholamreza Hassanzadeh Ghassabeh; Eveline Peeters; Dirk Saerens; Daniel Charlier; Serge Muyldermans
Nanobody-based chromatin immunoprecipitation.
Methods in molecular biology (Clifton, N.J.) 2012;911():491-505.
2012: Mireille Pellis; Serge Muyldermans; Cécile Vincke
Bacterial two hybrid: a versatile one-step intracellular selection method.
Methods in molecular biology (Clifton, N.J.) 2012;911():135-50.
2012: Cécile Vincke; Serge Muyldermans
Introduction to heavy chain antibodies and derived Nanobodies.
Methods in molecular biology (Clifton, N.J.) 2012;911():15-26.
2011: M L V Hendrickx; Serge Muyldermans; Ann Gils; Gholamreza Hassanzadeh Ghassabeh; K Buelens; Griet Compernolle; A DE Winter; Paul J Declerck
TAFIa inhibiting nanobodies as profibrinolytic tools and discovery of a new TAFIa conformation.
Journal of thrombosis and haemostasis : JTH 2011;9(11):2268-77.
2011: Balkiss Bouhaouala-Zahar; Naima Abidi; Rahma Ben Abderrazek; Issam Hmila; Serge Muyldermans; Mohamed El Ayeb
Immunological aspects of scorpion toxins: current status and perspectives.
Inflammation & allergy drug targets 2011;10(5):358-68.
2011: Lea Olive Tchouate Gainkam; Serge Muyldermans; Leo van Grunsven; Christian Vanhove; Vicky Caveliers; Nick Devoogdt; Marleen Keyaerts; Tony Lahoutte
Correlation between epidermal growth factor receptor-specific nanobody uptake and tumor burden: a tool for noninvasive monitoring of tumor response to therapy.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2011;13(5):940-8.
2011: Rahma Ben Abderrazek; Naima Abidi; Mohamed El Ayeb; Issam Hmila; Serge Muyldermans; Dirk Saerens; Cécile Vincke; Balkiss Bouhaouala-Zahar
Development of Cys38 knock-out and humanized version of NbAahII10 nanobody with improved neutralization of AahII scorpion toxin.
Protein engineering, design & selection : PEDS 2011;24(9):727-35.
2011: Ilse Vaneycken; Cécile Vincke; Ulrich Wernery; Catarina Xavier; Nick Devoogdt; Tony Lahoutte; Serge Muyldermans; Naomi Van Gassen; Vicky Caveliers
Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(7):2433-46.
2011: Bieke Van de Broek; Nick Devoogdt; Antoine D'Hollander; Hannah-Laura Gijs; Karolien Jans; Liesbet Lagae; Guido Maes; Serge Muyldermans; Gustaaf Borghs
Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy.
ACS nano 2011;5(6):4319-28.
2011: Benoit Stijlemans; Lea Brys; Guy Caljon; Katja Conrath; Patrick De Baetselier; Mark C Field; Stefan Magez; Senthil Kumar A Natesan; Alexandros Nikolaou; Etienne Pays; David Pérez-Morga; Dirk Saerens; Jeremy N Skepper; Serge Muyldermans
High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.
PLoS pathogens 2011;7(6):e1002072.
2011: Bert Thys; Dirk Saerens; Lise Schotte; Gerrit De Bleeser; Serge Muyldermans; Gholamreza Hassanzadeh Ghassabeh; Bart Rombaut
A simple quantitative affinity capturing assay of poliovirus antigens and subviral particles by single-domain antibodies using magnetic beads.
Journal of virological methods 2011;173(2):300-5.
2011: Lea Olive Tchouate Gainkam; Vicky Caveliers; Nick Devoogdt; Christian Vanhove; Catarina Xavier; Otto Boerman; Serge Muyldermans; Axel Bossuyt; Tony Lahoutte
Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice.
Contrast media & molecular imaging 2011;6(2):85-92.
2011: Gholamreza Hassanzadeh Ghassabeh; Dirk Saerens; Serge Muyldermans
Generation of anti-infectome/anti-proteome nanobodies.
Methods in molecular biology (Clifton, N.J.) 2011;790():239-59.
2010: Dorota Smolarek; Claude Hattab; Gholamreza Hassanzadeh Ghassabeh; Sylvie Cochet; Carlos Gutiérrez; Alexandre G de Brevern; Rachanee Udomsangpetch; Julien Picot; Magdalena Grodecka; Kazimiera Wasniowska; Serge Muyldermans; Yves Colin; Caroline Le Van Kim; Marcin Czerwinski; Olivier Bertrand
A recombinant dromedary antibody fragment (VHH or nanobody) directed against human Duffy antigen receptor for chemokines.
Cellular and molecular life sciences : CMLS 2010;67(19):3371-87.
2010: Issam Hmila; Dirk Saerens; Rahma Ben Abderrazek; Cécile Vincke; Naima Abidi; Zakaria Benlasfar; Jochen Govaert; Mohamed El Ayeb; Balkiss Bouhaouala-Zahar; Serge Muyldermans
A bispecific nanobody to provide full protection against lethal scorpion envenoming.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(9):3479-89.
2010: Bert Thys; Lise Schotte; Serge Muyldermans; Ulrich Wernery; Gholamreza Hassanzadeh Ghassabeh; Bart Rombaut
In vitro antiviral activity of single domain antibody fragments against poliovirus.
Antiviral research 2010;87(2):257-64.
2010: Ilse Vaneycken; Jochen Govaert; Cécile Vincke; Vicky Caveliers; Tony Lahoutte; Patrick De Baetselier; Geert Raes; Axel Bossuyt; Serge Muyldermans; Nick Devoogdt
In vitro analysis and in vivo tumor targeting of a humanized, grafted nanobody in mice using pinhole SPECT/micro-CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(7):1099-106.
2010: Nick Deschacht; Kurt De Groeve; Cécile Vincke; Geert Raes; Patrick De Baetselier; Serge Muyldermans
A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5696-704.
2010: Kurt De Groeve; Nick Deschacht; Celine De Koninck; Vicky Caveliers; Tony Lahoutte; Nick Devoogdt; Serge Muyldermans; Patrick De Baetselier; Geert Raes
Nanobodies as tools for in vivo imaging of specific immune cell types.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(5):782-9.
2010: Axel Kirchhofer; Jonas Helma; Katrin Schmidthals; Carina Frauer; Sheng Cui; Annette Karcher; Mireille Pellis; Serge Muyldermans; Corella S Casas-Delucchi; M Cristina Cardoso; Heinrich Leonhardt; Karl-Peter Hopfner; Ulrich Rothbauer
Modulation of protein properties in living cells using nanobodies.
Nature structural & molecular biology 2010;17(1):133-8.
2009: Rahma Ben Abderrazek; Issam Hmila; Cécile Vincke; Zakaria Benlasfar; Mireille Pellis; Hafedh Dabbek; Dirk Saerens; Mohamed El Ayeb; Serge Muyldermans; Balkiss Bouhaouala-Zahar
Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom.
The Biochemical journal 2009;424(2):263-72.
2009: N Deckers; D Saerens; Kirezi Kanobana; K Conrath; Bjorn Victor; U Wernery; Jozef Vercruysse; Serge Muyldermans; Pierre Dorny
Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis.
International journal for parasitology 2009;39(5):625-33.
2009: John E Butler; Kelly M Lager; I Splichal; D Francis; I Kacskovics; Marek Sinkora; Nancy Wertz; Jishan Sun; Y Zhao; W R Brown; R DeWald; S Dierks; Serge Muyldermans; J K Lunney; Paul B McCray; C S Rogers; Michael J Welsh; P Navarro; F Klobasa; F Habe; J Ramsoondar
The piglet as a model for B cell and immune system development.
Veterinary immunology and immunopathology 2009;128(1-3):147-70.
2009: Serge Muyldermans; Toya Nath Baral; V Cortez Retamozzo; Patrick De Baetselier; Erwin De Genst; Jörg Kinne; H Leonhardt; Stefan Magez; Viet Khong Nguyen; Hilde Revets; U Rothbauer; Benoit Stijlemans; S Tillib; Ulrich Wernery; Lode Wyns; Gh Hassanzadeh-Ghassabeh; Dirk Saerens
Camelid immunoglobulins and nanobody technology.
Veterinary immunology and immunopathology 2009;128(1-3):178-83.
2009: Katja Conrath; Alice S Pereira; Carlos E Martins; Cristina G Timóteo; Pedro Tavares; Silvia Spinelli; Jörg Kinne; Christophe Flaudrops; Christian Cambillau; Serge Muyldermans; Isabel Moura; Jose J G Moura; Mariella Tegoni; Aline Desmyter
Camelid nanobodies raised against an integral membrane enzyme, nitric oxide reductase.
Protein science : a publication of the Protein Society 2009;18(3):619-28.
2009: Cécile Vincke; Remy Loris; Dirk Saerens; Sergio Martinez-Rodriguez; Serge Muyldermans; Katja Conrath
General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.
The Journal of biological chemistry 2009;284(5):3273-84.
2008: Pak-Ho Chan; Els Pardon; Linda Menzer; Erwin De Genst; Janet R Kumita; John Christodoulou; Dirk Saerens; Alain Brans; Fabrice Bouillenne; David B Archer; Carol V Robinson; Serge Muyldermans; Alain Matagne; Christina Redfield; Lode Wyns; Christopher M Dobson; Mireille Dumoulin
Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Biochemistry 2008;47(42):11041-54.
2008: Dirk Saerens; Gholamreza Hassanzadeh Ghassabeh; Serge Muyldermans
Single-domain antibodies as building blocks for novel therapeutics.
Current opinion in pharmacology 2008;8(5):600-8.
2008: Issam Hmila; Ben Abderrazek-Ben Abdallah R; Dirk Saerens; Zakaria Benlasfar; Katja Conrath; Mohamed El Ayeb; Serge Muyldermans; Balkiss Bouhaouala-Zahar
VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'.
Molecular immunology 2008;45(14):3847-56.
2008: Dirk Saerens; Gholamreza Hassanzadeh Ghassabeh; Serge Muyldermans
Antibody technology in proteomics.
Briefings in functional genomics & proteomics 2008;7(4):275-82.
2008: Dirk Saerens; Katja Conrath; Jochen Govaert; Serge Muyldermans
Disulfide bond introduction for general stabilization of immunoglobulin heavy-chain variable domains.
Journal of molecular biology 2008;377(2):478-88.
2008: Ulrich Rothbauer; Kourosh Zolghadr; Serge Muyldermans; Aloys Schepers; M Cristina Cardoso; Heinrich Leonhardt
A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins.
Molecular & cellular proteomics : MCP 2008;7(2):282-9.
2008: Dirk Saerens; Benoit Stijlemans; Toya Nath Baral; Giang Thanh Nguyen Thi; Ulrich Wernery; Stefan Magez; Patrick De Baetselier; Serge Muyldermans; Katja Conrath
Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens.
Journal of immunological methods 2008;329(1-2):138-50.
2007: Aurelien Olichon; Daniel Schweizer; Serge Muyldermans; Ario de Marco
Heating as a rapid purification method for recovering correctly-folded thermotolerant VH and VHH domains.
BMC biotechnology 2007;7():7.
2007: Michael J Taussig; Oda Stoevesandt; Carl A K Borrebaeck; Andrew R Bradbury; Dolores Cahill; Christian Cambillau; Antoine de Daruvar; Stefan Dübel; Jutta Eichler; Ronald Frank; Toby J Gibson; David Gloriam; Larry Gold; Friedrich W Herberg; Henning Hermjakob; Jörg D Hoheisel; Thomas O Joos; Olli Kallioniemi; Manfred Koegl; Manfred Koegll; Zoltán Konthur; Bernhard Korn; Elisabeth Kremmer; Sylvia Krobitsch; Ulf Landegren; Silvère van der Maarel; John McCafferty; Serge Muyldermans; Per-Ake Nygren; sandrine palcy; Andreas Plückthun; Bojan Polic; Michael Przybylski; Petri Saviranta; Alan Sawyer; David Sherman; Arne Skerra; Markus Templin; Marius Ueffing; Mathias Uhlén
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.
Nature methods 2007;4(1):13-7.
2006: Toya Nath Baral; Stefan Magez; Benoit Stijlemans; Katja Conrath; Benoit Vanhollebeke; Etienne Pays; Serge Muyldermans; Patrick De Baetselier
[Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor].
Médecine sciences : M/S 2006;22(11):914-6.
2006: Ulrich Rothbauer; Kourosh Zolghadr; Sergei Tillib; Danny Nowak; Lothar Schermelleh; Anja Gahl; Natalija Backmann; Katja Conrath; Serge Muyldermans; M Cristina Cardoso; Heinrich Leonhardt
Targeting and tracing antigens in live cells with fluorescent nanobodies.
Nature methods 2006;3(11):887-9.
2006: Toya Nath Baral; Stefan Magez; Benoit Stijlemans; Katja Conrath; Benoit Vanhollebeke; Etienne Pays; Serge Muyldermans; Patrick De Baetselier
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor.
Nature medicine 2006;12(5):580-4.
2006: Erwin De Genst; Karen Silence; Klaas Decanniere; Katja Conrath; Remy Loris; Jörg Kinne; Serge Muyldermans; Lode Wyns
Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4586-91.
2006: Andreas Marquardt; Serge Muyldermans; Michael Przybylski
A synthetic camel anti-lysozyme peptide antibody (peptibody) with flexible loop structure identified by high-resolution affinity mass spectrometry.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(7):1915-23.
2006: Marianne Brüggemann; Jennifer Smith; Michael J Osborn; Daniel Corcos; Xiangang Zou; Viet Khong Nguyen; Serge Muyldermans
Heavy-chain-only antibody expression and B-cell development in the mouse.
Critical reviews in immunology 2006;26(5):377-90.
2006: Imre Kacskovics; Balázs Mayer; Zsuzsanna Kis; László V Frenyó; Yaofeng Zhao; Serge Muyldermans; Lennart Hammarström
Cloning and characterization of the dromedary (Camelus dromedarius) neonatal Fc receptor (drFcRn).
Developmental and comparative immunology 2006;30(12):1203-15.
2006: Erwin De Genst; Dirk Saerens; Serge Muyldermans; Katja Conrath
Antibody repertoire development in camelids.
Developmental and comparative immunology 2006;30(1-2):187-98.
2005: Dirk Saerens; Filip Frederix; Gunter Reekmans; Katja Conrath; Karolien Jans; Lea Brys; Lieven Huang; Eugene Bosmans; Guido Maes; Gustaaf Borghs; Serge Muyldermans
Engineering camel single-domain antibodies and immobilization chemistry for human prostate-specific antigen sensing.
Analytical chemistry 2005;77(23):7547-55.
2005: Dirk Saerens; Mireille Pellis; Remy Loris; Els Pardon; Mireille Dumoulin; Alain Matagne; Lode Wyns; Serge Muyldermans; Katja Conrath
Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies.
Journal of molecular biology 2005;352(3):597-607.
2005: Xiangang Zou; Jennifer Smith; Viet Khong Nguyen; Liming Ren; Kattie Luyten; Serge Muyldermans; Marianne Brüggemann
Expression of a dromedary heavy chain-only antibody and B cell development in the mouse.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3769-79.
2005: Lieven Huang; Gunter Reekmans; Dirk Saerens; Jean-Michel Friedt; Filip Frederix; Laurent Francis; Serge Muyldermans; Andrew Campitelli; Chris Van Hoof
Prostate-specific antigen immunosensing based on mixed self-assembled monolayers, camel antibodies and colloidal gold enhanced sandwich assays.
Biosensors & bioelectronics 2005;21(3):483-90.
2005: Katja Conrath; Cécile Vincke; Benoit Stijlemans; Joost Schymkowitz; Klaas Decanniere; Lode Wyns; Serge Muyldermans; Remy Loris
Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH.
Journal of molecular biology 2005;350(1):112-25.
2005: Erwin De Genst; Karen Silence; Mehdi Arbabi Ghahroudi; Klaas Decanniere; Remy Loris; Jörg Kinne; Lode Wyns; Serge Muyldermans
Strong in vivo maturation compensates for structurally restricted H3 loops in antibody repertoires.
The Journal of biological chemistry 2005;280(14):14114-21.
2005: Mireille Dumoulin; Denis Canet; Alexander M Last; Els Pardon; David B Archer; Serge Muyldermans; Lode Wyns; Alain Matagne; Carol V Robinson; Christina Redfield; Christopher M Dobson
Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.
Journal of molecular biology 2005;346(3):773-88.
2005: Hilde Revets; Patrick De Baetselier; Serge Muyldermans
Nanobodies as novel agents for cancer therapy.
Expert opinion on biological therapy 2005;5(1):111-24.
2004: Erwin De Genst; Fabian Handelberg; Annemieke Van Meirhaeghe; Samuel Vynck; Remy Loris; Lode Wyns; Serge Muyldermans
Chemical basis for the affinity maturation of a camel single domain antibody.
The Journal of biological chemistry 2004;279(51):53593-601.
2004: Dirk Saerens; Jörg Kinne; Eugene Bosmans; Ulrich Wernery; Serge Muyldermans; Katja Conrath
Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen.
The Journal of biological chemistry 2004;279(50):51965-72.
2004: Magdalena Pleschberger; Dirk Saerens; Stefan Weigert; Uwe B Sleytr; Serge Muyldermans; Margit Sára; Eva M Egelseer
An S-layer heavy chain camel antibody fusion protein for generation of a nanopatterned sensing layer to detect the prostate-specific antigen by surface plasmon resonance technology.
Bioconjugate chemistry 2004;15(3):664-71.
2004: Virna Cortez-Retamozo; Natalija Backmann; Peter D Senter; Ullrich Wernery; Patrick De Baetselier; Serge Muyldermans; Hilde Revets
Efficient cancer therapy with a nanobody-based conjugate.
Cancer research 2004;64(8):2853-7.
2004: Benoit Stijlemans; Katja Conrath; Virna Cortez-Retamozo; Huang Van Xong; Lode Wyns; Peter D Senter; Hilde Revets; Patrick De Baetselier; Serge Muyldermans; Stefan Magez
Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm.
The Journal of biological chemistry 2004;279(2):1256-61.
2003: Bart De Cat; Serge Muyldermans; Christien Coomans; Gisèle Degeest; Bernadette Vanderschueren; John W M Creemers; Frédéric Biemar; Bernard Peers; Guido David
Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.
The Journal of cell biology 2003;163(3):625-35.
2003: Mireille Dumoulin; Alexander M Last; Aline Desmyter; Klaas Decanniere; Denis Canet; Göran Larsson; Andrew Spencer; David B Archer; Jurgen Sasse; Serge Muyldermans; Lode Wyns; Christina Redfield; Alain Matagne; Carol V Robinson; Christopher M Dobson
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.
Nature 2003;424(6950):783-8.
2003: Remy Loris; Irina Marianovsky; Jurij Lah; Toon Laeremans; Hanna Engelberg-Kulka; Gad Glaser; Serge Muyldermans; Lode Wyns
Crystal structure of the intrinsically flexible addiction antidote MazE.
The Journal of biological chemistry 2003;278(30):28252-7.
2003: Viet Khong Nguyen; Xiangang Zou; Marc Lauwereys; Lea Brys; Marianne Brüggemann; Serge Muyldermans
Heavy-chain only antibodies derived from dromedary are secreted and displayed by mouse B cells.
Immunology 2003;109(1):93-101.
2003: Magdalena Pleschberger; Angela Neubauer; Eva M Egelseer; Stefan Weigert; Brigitte Lindner; Uwe B Sleytr; Serge Muyldermans; Margit Sára
Generation of a functional monomolecular protein lattice consisting of an s-layer fusion protein comprising the variable domain of a camel heavy chain antibody.
Bioconjugate chemistry 2003;14(2):440-8.
2003: Katja Conrath; Ulrich Wernery; Serge Muyldermans; Viet Khong Nguyen
Emergence and evolution of functional heavy-chain antibodies in Camelidae.
Developmental and comparative immunology 2003;27(2):87-103.
2002: Erwin De Genst; Daphne Areskoug; Klaas Decanniere; Serge Muyldermans; Karl Andersson
Kinetic and affinity predictions of a protein-protein interaction using multivariate experimental design.
The Journal of biological chemistry 2002;277(33):29897-907.
2002: Aline Desmyter; Silvia Spinelli; Francoise Payan; Marc Lauwereys; Lode Wyns; Serge Muyldermans; Christian Cambillau
Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
The Journal of biological chemistry 2002;277(26):23645-50.
2002: Viet Khong Nguyen; Chen Su; Serge Muyldermans; Wessel van der Loo
Heavy-chain antibodies in Camelidae; a case of evolutionary innovation.
Immunogenetics 2002;54(1):39-47.
2002: Virna Cortez-Retamozo; Marc Lauwereys; Gholamreza Hassanzadeh Gh; Martine Gobert; Katja Conrath; Serge Muyldermans; Patrick De Baetselier; Hilde Revets
Efficient tumor targeting by single-domain antibody fragments of camels.
International journal of cancer. Journal international du cancer 2002;98(3):456-62.
2002: Mireille Dumoulin; Katja Conrath; Annemie Van Meirhaeghe; Filip Meersman; Karel Heremans; Leon G J Frenken; Serge Muyldermans; Lode Wyns; Alain Matagne
Single-domain antibody fragments with high conformational stability.
Protein science : a publication of the Protein Society 2002;11(3):500-15.
2001: Klaas Decanniere; TR Transue; Aline Desmyter; Dominique Maes; Serge Muyldermans; Lode Wyns
Degenerate interfaces in antigen-antibody complexes.
Journal of molecular biology 2001;313(3):473-8.
2001: Katja Conrath; Marc Lauwereys; Moreno Galleni; Alain Matagne; Jean-Marie Frère; Jörg Kinne; Lode Wyns; Serge Muyldermans
Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae.
Antimicrobial agents and chemotherapy 2001;45(10):2807-12.
2001: Aline Desmyter; Klaas Decanniere; Serge Muyldermans; Lode Wyns
Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody.
The Journal of biological chemistry 2001;276(28):26285-90.
2001: Serge Muyldermans
Single domain camel antibodies: current status.
Journal of biotechnology 2001;74(4):277-302.
2001: Serge Muyldermans; C Cambillau; L Wyns
Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains.
Trends in biochemical sciences 2001;26(4):230-5.
2001: K Els Conrath; Marc Lauwereys; Lode Wyns; Serge Muyldermans
Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs.
The Journal of biological chemistry 2001;276(10):7346-50.
2001: Viet Khong Nguyen; Aline Desmyter; Serge Muyldermans
Functional heavy-chain antibodies in Camelidae.
Advances in immunology 2001;79():261-96.
2000: Klaas Decanniere; Serge Muyldermans; Lode Wyns
Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?
Journal of molecular biology 2000;300(1):83-91.
2000: M Veugelers; B D Cat; Serge Muyldermans; Gunter Reekmans; Nathalie Delande; Suzanna G M Frints; Eric Legius; Jean-Pierre Fryns; C T R M Schrander-Stumpel; B Weidle; N Magdalena; Guido David
Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.
Human molecular genetics 2000;9(9):1321-8.
2000: Viet Khong Nguyen; R Hamers; Lode Wyns; Serge Muyldermans
Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire.
The EMBO journal 2000;19(5):921-30.
1999: Lutz Riechmann; Serge Muyldermans
Single domain antibodies: comparison of camel VH and camelised human VH domains.
Journal of immunological methods 1999;231(1-2):25-38.
1999: Viet Khong Nguyen; R Hamers; Lode Wyns; Serge Muyldermans
Loss of splice consensus signal is responsible for the removal of the entire C(H)1 domain of the functional camel IGG2A heavy-chain antibodies.
Molecular immunology 1999;36(8):515-24.
1999: Klaas Decanniere; Aline Desmyter; Marc Lauwereys; Mehdi Arbabi Ghahroudi; Serge Muyldermans; Lode Wyns
A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops.
Structure (London, England : 1993) 1999;7(4):361-70.
1999: V Gupta; Serge Muyldermans; L Wyns; Dinakar M Salunke
The crystal structure of recombinant rat pancreatic RNase A.
Proteins 1999;35(1):1-12.
1999: Serge Muyldermans; Marc Lauwereys
Unique single-domain antigen binding fragments derived from naturally occurring camel heavy-chain antibodies.
Journal of molecular recognition : JMR 1999;12(2):131-40.
1998: A Gaballa; Christine Baysse; Nico Koedam; Serge Muyldermans; Pierre Cornelis
Different residues in periplasmic domains of the CcmC inner membrane protein of Pseudomonas fluorescens ATCC 17400 are critical for cytochrome c biogenesis and pyoverdine-mediated iron uptake.
Molecular microbiology 1998;30(3):547-55.
1998: Gholamreza Hassanzadeh Gh; Nick Devoogdt; Alain Ghysen; Patrick De Baetselier; Serge Muyldermans; Christine Dambly-Chaudière
The regulated expression of an intrabody produces a mutant phenotype in Drosophila.
FEBS letters 1998;437(1-2):81-6.
1998: Gholamreza Hassanzadeh Gh; K S De Silva; Christine Dambly-Chaudière; Lea Brys; Alain Ghysen; R Hamers; Serge Muyldermans; Patrick De Baetselier
Isolation and characterization of single-chain Fv genes encoding antibodies specific for Drosophila Poxn protein.
FEBS letters 1998;437(1-2):75-80.
1998: Y B Zhou; S E Gerchman; V Ramakrishnan; A Travers; Serge Muyldermans
Position and orientation of the globular domain of linker histone H5 on the nucleosome.
Nature 1998;395(6700):402-5.
1998: TR Transue; Erwin De Genst; Mehdi Arbabi Ghahroudi; Lode Wyns; Serge Muyldermans
Camel single-domain antibody inhibits enzyme by mimicking carbohydrate substrate.
Proteins 1998;32(4):515-22.
1998: Marc Lauwereys; M Arbabi Ghahroudi; Aline Desmyter; Jörg Kinne; W Hölzer; Erwin De Genst; Lode Wyns; Serge Muyldermans
Potent enzyme inhibitors derived from dromedary heavy-chain antibodies.
The EMBO journal 1998;17(13):3512-20.
1998: Viet Khong Nguyen; Serge Muyldermans; R Hamers
The specific variable domain of camel heavy-chain antibodies is encoded in the germline.
Journal of molecular biology 1998;275(3):413-8.
1997: K B Vu; Mehdi Arbabi Ghahroudi; Lode Wyns; Serge Muyldermans
Comparison of llama VH sequences from conventional and heavy chain antibodies.
Molecular immunology 1997;34(16-17):1121-31.
1997: M Arbabi Ghahroudi; Aline Desmyter; Lode Wyns; R Hamers; Serge Muyldermans
Selection and identification of single domain antibody fragments from camel heavy-chain antibodies.
FEBS letters 1997;414(3):521-6.
1996: Aline Desmyter; TR Transue; Mehdi Arbabi Ghahroudi; M H Thi; F Poortmans; R Hamers; Serge Muyldermans; Lode Wyns
Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme.
Nature structural biology 1996;3(9):803-11.
1996: A A Travers; Serge Muyldermans
A DNA sequence for positioning chromatosomes.
Journal of molecular biology 1996;257(3):486-91.
1994: Serge Muyldermans; J De Jonge; Lode Wyns; A A Travers
Differential association of linker histones H1 and H5 with telomeric nucleosomes in chicken erythrocytes.
Nucleic acids research 1994;22(25):5635-9.
1994: C Cerf; G Lippens; V Ramakrishnan; Serge Muyldermans; A Segers; Lode Wyns; Shoshana J Wodak; K Hallenga
Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: full assignment, tertiary structure, and comparison with the globular domain of histone H5.
Biochemistry 1994;33(37):11079-86.
1994: Serge Muyldermans; T Atarhouch; J Saldanha; J A Barbosa; R Hamers
Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains.
Protein engineering 1994;7(9):1129-35.
1994: Serge Muyldermans; A A Travers
DNA sequence organization in chromatosomes.
Journal of molecular biology 1994;235(3):855-70.
1993: C Cerf; G Lippens; Serge Muyldermans; A Segers; V Ramakrishnan; Shoshana J Wodak; K Hallenga; Lode Wyns
Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: sequential assignment and secondary structure.
Biochemistry 1993;32(42):11345-51.
1993: C Hamers-Casterman; T Atarhouch; Serge Muyldermans; G Robinson; C Hamers; E B Songa; N Bendahman; R Hamers
Naturally occurring antibodies devoid of light chains.
Nature 1993;363(6428):446-8.
1992: J Liu; G Salinas; N Gajendran; D Muthui; Serge Muyldermans; R Hamers
DNA recombination associated with short direct repeats in Leishmania mexicana M379.
Molecular and biochemical parasitology 1992;50(2):351-3.
1991: S Lambert; Serge Muyldermans; J Baldwin; J Kilner; K Ibel; L Wijns
Neutron scattering studies of chromatosomes.
Biochemical and biophysical research communications 1991;179(2):810-6.
1991: J H Liu; N Gajendran; D Muthui; Serge Muyldermans; Jean-Claude Dujardin; Simonne De Doncker; Diane Jacquet; Dominique Le Ray; F Mathieu-Daudé; R Hamers
Chromosome rearrangement in Leishmania mexicana M379.
Molecular and biochemical parasitology 1991;46(1):53-60.
1991: A Segers; Serge Muyldermans; Lode Wyns
The interaction of histone H5 and its globular domain with core particles, depleted chromatosomes, polynucleosomes, and a DNA decamer.
The Journal of biological chemistry 1991;266(3):1502-8.
1989: Sari Pennings; Serge Muyldermans; G Meersseman; Lode Wyns
Formation, stability and core histone positioning of nucleosomes reassembled on bent and other nucleosome-derived DNA.
Journal of molecular biology 1989;207(1):183-92.
1988: Sari Pennings; Serge Muyldermans; Lode Wyns
Comparative filter binding study of H5 to nucleosome core particles, H1, H5 depleted chromatosomes and DNA fragments.
Molecular biology reports 1988;13(4):191-6.
1986: Sari Pennings; Serge Muyldermans; Lode Wyns
Limitations of the poly(glutamic acid) reconstitution method in the reassembly of mono- and dinucleosomes.
Biochemistry 1986;25(18):5043-51.
1985: I Lasters; Lode Wyns; Serge Muyldermans; J P Baldwin; G A Poland; C Nave
Scatter analysis of discrete-sized chromatin fragments favours a cylindrical organization.
European journal of biochemistry / FEBS 1985;151(2):283-9.
1985: Serge Muyldermans; I Lasters; R Hamers; Lode Wyns
Assembly of oligonucleosomes into a limit series of multimeric higher-order chromatin structures.
European journal of biochemistry / FEBS 1985;150(3):441-6.
1985: F Michiels; Serge Muyldermans; R Hamers; G Matthyssens
Putative regulatory sequences for the transcription of mini-exons in Trypanosoma brucei as revealed by S1 sensitivity.
Gene 1985;36(3):263-70.
1981: C Houssier; I Lasters; Serge Muyldermans; Lode Wyns
The structural organization of dinucleosomes and oligonucleosomes. Electric dichroism and birefringence study.
Nucleic acids research 1981;9(21):5763-84.
1981: Serge Muyldermans; I Lasters; Lode Wyns; R Hamers
Protection of discrete DNA fragments by the complex H1-octamerhistones or H5-octamerhistones after micrococcal nuclease digestion.
Nucleic acids research 1981;9(15):3671-80.
1981: I Lasters; Serge Muyldermans; Lode Wyns; R Hamers
Differences in rearrangements of H1 and H5 in chicken erythrocyte chromatin.
Biochemistry 1981;20(5):1104-10.
1980: Serge Muyldermans; I Lasters; Lode Wyns; R Hamers
Preparation and purification of mononucleosome particles containing histone H5.
FEBS letters 1980;119(1):93-6.
1980: Serge Muyldermans; I Lasters; Lode Wyns; R Hamers
Upon the observation of superbeads in chromatin.
Nucleic acids research 1980;8(10):2165-72.
1980: Serge Muyldermans; I Lasters; Lode Wyns
Histone H1 can be removed selectively from chicken erythrocyte chromatin at near physiological conditions.
Nucleic acids research 1980;8(4):731-9.
1980: Serge Muyldermans; I Lasters; Lode Wyns
Preparation and behaviour of H1-depleted, H5-containing chicken erythrocyte chromatin [proceedings].
Archives internationales de physiologie et de biochimie 1980;88(1):B42-B43.