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Jean Plum

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Jessica Filtjens; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Aline Van Acker; Els Van Ammel; Bart Vandekerckhove; Mandy Vanhees; Georges Leclercq
Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.
Inge Van de Walle; Bart Vandekerckhove; Els Waegemans; Tao Wang; Jelle De Medts; Magda De Smedt; Greet De Smet; Thomas Gridley; Tessa Kerre; Ute Koch; Georges Leclercq; Jean Plum; Freddy Radtke; Sylvia Snauwaert; Tom Taghon
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
Tina Van Den Broeck; Bart Vandekerckhove; Maarten Delforche; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Els Van Ammel; Georges Leclercq
Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.

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All Publications

2013: Jessica Filtjens; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Aline Van Acker; Els Van Ammel; Bart Vandekerckhove; Mandy Vanhees; Georges Leclercq
Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.
Journal of leukocyte biology 2013;93(5):699-711.
2013: Inge Van de Walle; Bart Vandekerckhove; Els Waegemans; Tao Wang; Jelle De Medts; Magda De Smedt; Greet De Smet; Thomas Gridley; Tessa Kerre; Ute Koch; Georges Leclercq; Jean Plum; Freddy Radtke; Sylvia Snauwaert; Tom Taghon
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
The Journal of experimental medicine 2013;210(4):683-97.
2013: Tina Van Den Broeck; Bart Vandekerckhove; Maarten Delforche; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Els Van Ammel; Georges Leclercq
Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):1982-90.
2012: Sylvia Snauwaert; Tom Taghon; Kris Thielemans; Yasmine Van Caeneghem; Zwi N Berneman; Glenn Goetgeluk; Tessa C C Kerre; Georges Leclercq; Jan Philippé; Jean Plum; Stijn Vanhee; Imke Velghe; Greet Verstichel; Bart Vandekerckhove
RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia.
Haematologica 2012;97(10):1539-47.
2011: Reinhart Speeckaert; JT Van Acker; Filip Van Wanzeele; Chris Verhofstede; Vic Arendt; Johan R Boelaert; Lieve Brochez; Bob Colebunders; Marc De Buyzere; Robert Hemmer; Jean Plum; Marijn Speeckaert; Joris R Delanghe
Association of haptoglobin phenotypes with the development of Kaposi's sarcoma in HIV patients.
Archives of dermatological research 2011;303(10):763-9.
2011: Veerle De Colvenaer; Magda De Smedt; Maarten Delforche; Jean Plum; Tom Taghon; Sylvie Taveirne; Bart Vandekerckhove; Louis Boon; Georges Leclercq
CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation.
Immunology and cell biology 2011;89(7):803-11.
2011: Sylvie Taveirne; Els Van Ammel; Tina Van Den Broeck; Bart Vandekerckhove; Clare L Bennett; Björn E Clausen; Veerle De Colvenaer; Daniel H Kaplan; Jean Plum; Tom Taghon; Georges Leclercq
Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function.
Journal of leukocyte biology 2011;90(1):61-8.
2011: Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Tessa Kerre; Tom Taghon; Jean Plum
T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells.
Haematologica 2011;96(5):646-54.
2011: Inge Van de Walle; Greet De Smet; Martina Gärtner; Magda De Smedt; Els Waegemans; Bart Vandekerckhove; Georges Leclercq; Jean Plum; Jon C Aster; Irwin D Bernstein; Cynthia J Guidos; Bruno Kyewski; Tom Taghon
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
Blood 2011;117(17):4449-59.
2011: Linos Vandekerckhove; Chris Verhofstede; Els Demecheleer; Stephane De Wit; Eric Florence; Katrien Fransen; Michel Moutschen; Wendy Mostmans; Kabamba Kabeya; Nicola Mackie; Jean Plum; Dolores Vaira; Kurt Van Baelen; Ina Vandenbroucke; Veerle Van Eygen; Herwig Van Marck; Dirk Vogelaers; Anna Maria Geretti; Lieven Stuyver
Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment.
The Journal of antimicrobial chemotherapy 2011;66(2):265-72.
2011: Bart Vandekerckhove; Stijn Vanhee; Stefanie Van Coppernolle; Sylvia Snauwaert; Imke Velghe; Tom Taghon; Georges Leclercq; Tessa C C Kerre; Jean Plum
In vitro generation of immune cells from pluripotent stem cells.
Frontiers in bioscience : a journal and virtual library 2011;16():1488-504.
2010: Chris Verhofstede; Filip Van Wanzeele; Jacqueline Reynaerts; Marianne Mangelschots; Jean Plum; Katrien Fransen
Viral load assay sensitivity and low level viremia in HAART treated HIV patients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2010;47(4):335-9.
2010: Kaatje Smits; Veronica Iannucci; Veronique Stove; Peter Van Hauwe; Evelien Naessens; Pieter J Meuwissen; Kevin K Ariën; Mostafa Bentahir; Jean Plum; Bruno Verhasselt
Rho GTPase Cdc42 is essential for human T-cell development.
Haematologica 2010;95(3):367-75.
2010: Jean Plum
A Notch stairway to thymus?
Blood 2010;115(2):155-6.
2010: Kristen Chalmet; Delfien Staelens; Stijn I Blot; Sylvie Dinakis; Jolanda Pelgrom; Jean Plum; Dirk Vogelaers; Linos Vandekerckhove; Chris Verhofstede
Epidemiological study of phylogenetic transmission clusters in a local HIV-1 epidemic reveals distinct differences between subtype B and non-B infections.
BMC infectious diseases 2010;10():262.
2009: Stefanie Van Coppernolle; Greet Verstichel; Frank Timmermans; Imke Velghe; David Vermijlen; Magda De Smedt; Georges Leclercq; Jean Plum; Tom Taghon; Bart Vandekerckhove; Tessa C C Kerre
Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):4859-70.
2009: Frank Timmermans; Imke Velghe; Lieve Vanwalleghem; Magda De Smedt; Stefanie Van Coppernolle; Tom Taghon; Harry D Moore; Georges Leclercq; Anton Langerak; Tessa C C Kerre; Jean Plum; Bart Vandekerckhove
Generation of T cells from human embryonic stem cell-derived hematopoietic zones.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6879-88.
2009: Tom Taghon; Inge Van de Walle; Greet De Smet; Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Jean Plum
Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development.
Blood 2009;113(14):3254-63.
2009: Inge Van de Walle; Greet De Smet; Magda De Smedt; Bart Vandekerckhove; Georges Leclercq; Jean Plum; Tom Taghon
An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.
Blood 2009;113(13):2988-98.
2009: Chris Verhofstede; Linos Vandekerckhove; Veerle Van Eygen; Els Demecheleer; Ina Vandenbroucke; Bart Winters; Jean Plum; Dirk Vogelaers; Lieven Stuyver
CXCR4-using HIV type 1 variants are more commonly found in peripheral blood mononuclear cell DNA than in plasma RNA.
Journal of acquired immune deficiency syndromes (1999) 2009;50(2):126-36.
2009: Kim Steegen; Stanley Luchters; Kenny Dauwe; Jacqueline Reynaerts; Kishor Mandaliya; Walter Jaoko; Jean Plum; Marleen Temmerman; Chris Verhofstede
Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya.
AIDS research and therapy 2009;6():12.
2009: Frank Timmermans; Jean Plum; Mervin C Yöder; David A Ingram; Bart Vandekerckhove; Jamie Case
Endothelial progenitor cells: identity defined?
Journal of cellular and molecular medicine 2009;13(1):87-102.
2008: Tina Van Den Broeck; Frederik Stevenaert; Sylvie Taveirne; Veronique Debacker; Christel Vangestel; Bart Vandekerckhove; Tom Taghon; Patrick Matthys; Jean Plum; Werner Held; Mieke Dewerchin; Wayne M Yokoyama; Georges Leclercq
Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.
Blood 2008;112(13):5046-51.
2008: Jean Plum; Magda De Smedt; Georges Leclercq; Tom Taghon; Tessa C C Kerre; Bart Vandekerckhove
Human intrathymic development: a selective approach.
Seminars in immunopathology 2008;30(4):411-23.
2008: Kristen Chalmet; Filip Van Wanzeele; Els Demecheleer; Kenny Dauwe; Jolanda Pelgrom; Bea Van Der Gucht; Dirk Vogelaers; Jean Plum; Lieven Stuyver; Linos Vandekerckhove; Chris Verhofstede
Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability--a study of 4 individuals infected with closely related HIV-1 strains.
Virology 2008;379(2):213-22.
2007: Kim Steegen; Stanley Luchters; Nancy De Cabooter; Jacqueline Reynaerts; Kishorchandra Mandaliya; Jean Plum; Walter Jaoko; Chris Verhofstede; Marleen Temmerman
Evaluation of two commercially available alternatives for HIV-1 viral load testing in resource-limited settings.
Journal of virological methods 2007;146(1-2):178-87.
2007: Kim Steegen; Stanley Luchters; Els Demecheleer; Kenny Dauwe; Kishorchandra Mandaliya; Walter Jaoko; Jean Plum; Marleen Temmerman; Chris Verhofstede
Feasibility of detecting human immunodeficiency virus type 1 drug resistance in DNA extracted from whole blood or dried blood spots.
Journal of clinical microbiology 2007;45(10):3342-51.
2007: Magda De Smedt; Tom Taghon; Inge Van de Walle; Greet De Smet; Georges Leclercq; Jean Plum
Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.
Blood 2007;110(7):2696-703.
2007: Chris Verhofstede; Filip Van Wanzeele; Bea Van Der Gucht; Jolanda Pelgrom; Linos Vandekerckhove; Jean Plum; Dirk Vogelaers
Detection of drug resistance mutations as a predictor of subsequent virological failure in patients with HIV-1 viral rebounds of less than 1,000 RNA copies/ml.
Journal of medical virology 2007;79(9):1254-60.
2007: Kaatje Smits; Magda De Smedt; Evelien Naessens; Greet De Smet; Veronique Stove; Tom Taghon; Jean Plum; Bruno Verhasselt
Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34+ cord blood cells.
Experimental hematology 2007;35(8):1272-8.
2007: Frank Timmermans; Filip Van Hauwermeiren; Magda De Smedt; Robrecht Raedt; Frank Plasschaert; Marc L De Buyzere; Thierry C Gillebert; Jean Plum; Bart Vandekerckhove
Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1572-9.
2007: Inge Hoebeke; Magda De Smedt; Frank Stolz; Karin Pike-Overzet; Frank Staal; Jean Plum; Georges Leclercq
T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34(+)CD38(-)CD7(+) common lymphoid progenitors expressing lymphoid-specific genes.
Leukemia 2007;21(2):311-9.
2007: Robrecht Raedt; Jef Pinxteren; Annelies Van Dycke ; Anouk Waeytens; David Craeye; Frank Timmermans; Kristl Vonck; Bart Vandekerckhove; Jean Plum; Paul Boon
Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers.
Experimental neurology 2007;203(2):542-54.
2007: Katrien Vanheusden; Stefanie Van Coppernolle; Magda De Smedt; Jean Plum; Bart Vandekerckhove
In vitro expanded cells contributing to rapid severe combined immunodeficient repopulation activity are CD34+38-33+90+45RA-.
Stem cells (Dayton, Ohio) 2007;25(1):107-14.
2006: Kim Steegen; Els Demecheleer; Nancy De Cabooter; Dieudonné Nges; Marleen Temmerman; Peter Ndumbe; Kishorchandra Mandaliya; Jean Plum; Chris Verhofstede
A sensitive in-house RT-PCR genotyping system for combined detection of plasma HIV-1 and assessment of drug resistance.
Journal of virological methods 2006;133(2):137-45.
2006: Inge Hoebeke; Magda De Smedt; Inge Van de Walle; Katia Reynvoet; Greet De Smet; Jean Plum; Georges Leclercq
Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells.
Blood 2006;107(7):2879-81.
2006: Mikaël J Pittet; Asma Gati; Frédérique-Anne Le Gal; Gilles Bioley; Philippe Guillaume; Magda De Smedt; Jean Plum; Daniel E Speiser; Jean-Charles Cerottini; Pierre-Yves Dietrich; Pedro Romero; Alfred Zippelius
Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2330-6.
2005: Magda De Smedt; Inge Hoebeke; Katia Reynvoet; Georges Leclercq; Jean Plum
Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment.
Blood 2005;106(10):3498-506.
2005: Veronique Stove; Inge Van de Walle; Evelien Naessens; Elisabeth Coene; Christophe Stove; Jean Plum; Bruno Verhasselt
Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.
Journal of virology 2005;79(17):11422-33.
2005: Frederik Stevenaert; Katrien van Beneden; Veerle De Colvenaer; Ann Sophie Franki; Veronique Debacker; Tom Boterberg; Dieter Deforce; Klaus Pfeffer; Jean Plum; Dirk Elewaut; Georges Leclercq
Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression.
Blood 2005;106(3):956-62.
2005: Françoise Meylan; Magda De Smedt; Georges Leclercq; Jean Plum; Olivier Leupin; Samuel Marguerat; Bernard Conrad
Negative thymocyte selection to HERV-K18 superantigens in humans.
Blood 2005;105(11):4377-82.
2005: Ann Noë; Jean Plum; Chris Verhofstede
The latent HIV-1 reservoir in patients undergoing HAART: an archive of pre-HAART drug resistance.
The Journal of antimicrobial chemotherapy 2005;55(4):410-2.
2004: Magda De Smedt; Inge Hoebeke; Jean Plum
Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment.
Blood cells, molecules & diseases 2004;33(3):227-32.
2004: Chris Verhofstede; Ann Noë; Els Demecheleer; Nancy De Cabooter; Filip Van Wanzeele; Bea Van Der Gucht; Dirk Vogelaers; Jean Plum
Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy.
Journal of acquired immune deficiency syndromes (1999) 2004;35(5):473-83.
2004: Ann Noë; Chris Verhofstede; Jean Plum
The AIDS epidemic: the spread of a deadly disease in the biotech era.
Journal of biological regulators and homeostatic agents 2004;18(2):178-82.
2004: Alfred Zippelius; Gilles Bioley; Frédérique-Anne Le Gal; Nathalie Rufer; Marlene Brandes; Pascal Batard; Magda De Smedt; Jean Plum; Daniel E Speiser; Jean-Charles Cerottini; Pierre-Yves Dietrich; Pedro Romero; Mikaël J Pittet
Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2773-7.
2004: Sam Lievens; José Van der Heyden; Els Vertenten; Jean Plum; Joël Vandekerckhove; Jan Tavernier
Design of a fluorescence-activated cell sorting-based Mammalian protein-protein interaction trap.
Methods in molecular biology (Clifton, N.J.) 2004;263():293-310.
2003: Veronique Stove; Evelien Naessens; Christophe Stove; Tomek Swigut; Jean Plum; Bruno Verhasselt
Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development.
Blood 2003;102(8):2925-32.
2003: Frederik Stevenaert; Katrien van Beneden; An De Creus; Veronique Debacker; Jean Plum; Georges Leclercq
Ly49E expression points toward overlapping, but distinct, natural killer (NK) cell differentiation kinetics and potential of fetal versus adult lymphoid progenitors.
Journal of leukocyte biology 2003;73(6):731-8.
2003: Tom Taghon; K Thys; Magda De Smedt; Floor Weerkamp; Frank Staal; Jean Plum; Georges Leclercq
Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development.
Leukemia 2003;17(6):1157-63.
2003: Lin Weng; Dirk R Van Bockstaele; Jan Wauters; Eric Van Marck; Jean Plum; Zwi N Berneman; Joseph Merregaert
A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation.
The Journal of biological chemistry 2003;278(21):19164-70.
2003: Chris Verhofstede; Els Demecheleer; Nancy De Cabooter; Philippe Gaillard; Fabian Mwanyumba; Patricia Claeys; Varsha Chohan; Kishorchandra Mandaliya; Marleen Temmerman; Jean Plum
Diversity of the human immunodeficiency virus type 1 (HIV-1) env sequence after vertical transmission in mother-child pairs infected with HIV-1 subtype A.
Journal of virology 2003;77(5):3050-7.
2002: Magda De Smedt; Katia Reynvoet; Tessa C C Kerre; Tom Taghon; Bruno Verhasselt; Bart Vandekerckhove; Georges Leclercq; Jean Plum
Active form of Notch imposes T cell fate in human progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3021-9.
2002: An De Creus; Katrien van Beneden; Frederik Stevenaert; Veronique Debacker; Jean Plum; Georges Leclercq
Developmental and functional defects of thymic and epidermal V gamma 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6486-93.
2002: Katrien van Beneden; An De Creus; Frederik Stevenaert; Veronique Debacker; Jean Plum; Georges Leclercq
Expression of inhibitory receptors Ly49E and CD94/NKG2 on fetal thymic and adult epidermal TCR V gamma 3 lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3295-302.
2002: Tessa C C Kerre; Greet De Smet; Magda De Smedt; Alfred Zippelius; Mikaël J Pittet; Anton Langerak; José De Bosscher; Fritz Offner; Bart Vandekerckhove; Jean Plum
Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.
Blood 2002;99(5):1620-6.
2002: Alfred Zippelius; Mikaël J Pittet; Pascal Batard; Nathalie Rufer; Magda De Smedt; Philippe Guillaume; Kim Ellefsen; Danila Valmori; Danielle Liénard; Jean Plum; H Robson MacDonald; Daniel E Speiser; Jean-Charles Cerottini; Pedro Romero
Thymic selection generates a large T cell pool recognizing a self-peptide in humans.
The Journal of experimental medicine 2002;195(4):485-94.
2002: Tom Taghon; Frank Stolz; Magda De Smedt; Maggy Cnockaert; Bruno Verhasselt; Jean Plum; Georges Leclercq
HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor.
Blood 2002;99(4):1197-204.
2001: Tom Taghon; Magda De Smedt; Frank Stolz; M Cnockaert; Jean Plum; Georges Leclercq
Enforced expression of GATA-3 severely reduces human thymic cellularity.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4468-75.
2001: Tessa C C Kerre; Greet De Smet; Magda De Smedt; Fritz Offner; J De Bosscher; Jean Plum; Bart Vandekerckhove
Both CD34+38+ and CD34+38- cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3692-8.
2001: Katrien van Beneden; Frederik Stevenaert; An De Creus; Veronique Debacker; Jan A De Boever; Jean Plum; Georges Leclercq
Expression of Ly49E and CD94/NKG2 on fetal and adult NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4302-11.
2001: Griet Glorieux; C Hsu; Rita De Smet; Annemieke Dhondt; J van Emmelo ; Marie-Anne Waterloos; Norbert Lameire; Jean Plum; Raymond Vanholder
The anti-proliferative effect of calcitriol on HL-60 cells is neutralized by uraemic biological fluids.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(2):246-52.
2000: André Sasse; C Liesnard; Guido van der Groen; G Burtonboy; Jean Plum; D Sondag-Thull; S Sprecher; Marc Van Ranst; Georges Zissis; Jan Desmyter
Recent increase in diagnoses of HIV infections based on surveillance system data in Belgium.
AIDS (London, England) 2000;14(17):2798-800.
2000: Philippe Gaillard; Chris Verhofstede; Fabian Mwanyumba; Patricia Claeys; Varsha Chohan; Kishorchandra Mandaliya; Job Bwayo; Jean Plum; Marleen Temmerman
Exposure to HIV-1 during delivery and mother-to-child transmission.
AIDS (London, England) 2000;14(15):2341-8.
2000: An De Creus; Katrien van Beneden; Tom Taghon; Frank Stolz; Veronique Debacker; Jean Plum; Georges Leclercq
Langerhans cells that have matured in vivo in the absence of T cells are fully capable of inducing a helper CD4 as well as a cytotoxic CD8 response.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):645-53.
2000: Bruno Verhasselt; Evelien Naessens; Magda De Smedt; Jean Plum
Efficiency of transgenic T cell generation from gene-marked cultured human CD34+ cord blood cells is determined by their maturity and the cytokines present in the culture medium.
Gene therapy 2000;7(10):830-6.
2000: SF Weekx; Hans-Willem Snoeck; Fritz Offner; Magda De Smedt; Dirk R Van Bockstaele; Griet Nijs; Marc Lenjou; Adriaan C Moulijn; Inez E Rodrigus; Zwi N Berneman; Jean Plum
Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-alpha.
Blood 2000;95(9):2806-12.
2000: Magda De Smedt; Bruno Verhasselt; Tessa C C Kerre; D Vanhecke; Evelien Naessens; Georges Leclercq; J C Renauld; J Van Snick; Jean Plum
Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1761-7.
2000: Jean Plum; Magda De Smedt; Bruno Verhasselt; Tessa C C Kerre; D Vanhecke; Bart Vandekerckhove; Georges Leclercq
Human T lymphopoiesis. In vitro and in vivo study models.
Annals of the New York Academy of Sciences 2000;917():724-31.
1999: Chris Verhofstede; F V Wanzeele; Bea Van Der Gucht; Nancy De Cabooter; Jean Plum
Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype.
AIDS (London, England) 1999;13(18):2541-6.
1999: Bruno Verhasselt; Tessa C C Kerre; Evelien Naessens; D Vanhecke; Magda De Smedt; Bart Vandekerckhove; Jean Plum
Thymic repopulation by CD34(+) human cord blood cells after expansion in stroma-free culture.
Blood 1999;94(11):3644-52.
1999: Bruno Verhasselt; Evelien Naessens; Chris Verhofstede; Magda De Smedt; S Schollen; Tessa C C Kerre; D Vanhecke; Jean Plum
Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells.
Blood 1999;94(8):2809-18.
1999: Katrien van Beneden; An De Creus; Veronique Debacker; Jan A De Boever; Jean Plum; Georges Leclercq
Murine fetal natural killer cells are functionally and structurally distinct from adult natural killer cells.
Journal of leukocyte biology 1999;66(4):625-33.
1999: SF Weekx; Jean Plum; Philip Van Cauwelaert; Marc Lenjou; Griet Nijs; Magda De Smedt; M Vanhove; Philip Muylaert; Dirk R Van Bockstaele; Zwi N Berneman; Hans-Willem Snoeck
Developmentally regulated responsiveness to transforming growth factor-beta is correlated with functional differences between human adult and fetal primitive hematopoietic progenitor cells.
Leukemia 1999;13(8):1266-72.
1999: Fritz Offner; Tessa C C Kerre; Magda De Smedt; Jean Plum
Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy.
British journal of haematology 1999;104(4):801-8.
1999: Jean Plum
[Can T-cell immunity in an adult be regenerated?].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1999;61(3):457-64; discussion 464-5.
1999: Jean Plum; Magda De Smedt; Bruno Verhasselt; Fritz Offner; Tessa C C Kerre; D Vanhecke; Georges Leclercq; Bart Vandekerckhove
In vitro intrathymic differentiation kinetics of human fetal liver CD34+CD38- progenitors reveals a phenotypically defined dendritic/T-NK precursor split.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):60-8.
1998: SF Weekx; Dirk R Van Bockstaele; Jean Plum; Adriaan C Moulijn; Inez E Rodrigus; Filip Lardon; Magda De Smedt; Griet Nijs; Marc Lenjou; P Loquet; Zwi N Berneman; Hans-Willem Snoeck
CD34++ CD38- and CD34+ CD38+ human hematopoietic progenitors from fetal liver, cord blood, and adult bone marrow respond differently to hematopoietic cytokines depending on the ontogenic source.
Experimental hematology 1998;26(11):1034-42.
1998: Joris R Delanghe; Michel R Langlois; Johan R Boelaert; JT Van Acker; Filip Van Wanzeele; Guido van der Groen; Robert Hemmer; Chris Verhofstede; Marc L De Buyzere; Dirk De Bacquer; Vic Arendt; Jean Plum
Haptoglobin polymorphism, iron metabolism and mortality in HIV infection.
AIDS (London, England) 1998;12(9):1027-32.
1998: F Offner; Jean Plum
The role of interleukin-7 in early T-cell development.
Leukemia & lymphoma 1998;30(1-2):87-99.
1998: Bruno Verhasselt; Magda De Smedt; Rita Verhelst; Evelien Naessens; Jean Plum
Retrovirally transduced CD34++ human cord blood cells generate T cells expressing high levels of the retroviral encoded green fluorescent protein marker in vitro.
Blood 1998;91(2):431-40.
1997: D Vanhecke; Bruno Verhasselt; Magda De Smedt; Georges Leclercq; Jean Plum; Bart Vandekerckhove
Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5973-83.
1997: Fritz Offner; Katrien van Beneden; Veronique Debacker; D Vanhecke; Bart Vandekerckhove; Jean Plum; Georges Leclercq
Phenotypic and functional maturation of TCR gammadelta cells in the human thymus.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4634-41.
1997: D Vanhecke; Bruno Verhasselt; Magda De Smedt; B De Paepe; Georges Leclercq; Jean Plum; Bart Vandekerckhove
MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3730-7.
1997: Jean Plum
BSE: can we predict the future?
Bulletin et mémoires de l'Académie royale de médecine de Belgique 1997;152(6):264-73.
1997: Jean Plum
BSE: can we predict the future?
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1997;59(5):435-49.
1996: Georges Leclercq; Jean Plum
Thymic development of V gamma 3 cells.
Seminars in immunology 1996;8(6):315-21.
1996: G Leclercq; Jean Plum
Thymic and extrathymic T cell development.
Leukemia 1996;10(12):1853-9.
1996: Jean Plum; Magda De Smedt; Georges Leclercq; Bruno Verhasselt; Bart Vandekerckhove
Interleukin-7 is a critical growth factor in early human T-cell development.
Blood 1996;88(11):4239-45.
1996: Georges Leclercq; Veronique Debacker; M de Smedt; Jean Plum
Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.
The Journal of experimental medicine 1996;184(2):325-36.
1996: Chris Verhofstede; Katrien Fransen; D Marissens; Rita Verhelst; G van der Groen; Sabine Lauwers; G Zissis; Jean Plum
Isolation of HIV-1 RNA from plasma: evaluation of eight different extraction methods.
Journal of virological methods 1996;60(2):155-9.
1995: D Vanhecke; Bruno Verhasselt; Veronique Debacker; Georges Leclercq; Jean Plum; Bart Vandekerckhove
Differentiation to T helper cells in the thymus. Gradual acquisition of T helper cell function by CD3+CD4+ cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4711-8.
1995: D Vanhecke; Georges Leclercq; Jean Plum; Bart Vandekerckhove
Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1862-72.
1995: Jean Plum; Magda De Smedt; Georges Leclercq; Bart Vandekerckhove
Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):5789-98.
1995: Georges Leclercq; Jean Plum
Stimulation of TCR V gamma 3 cells by gram-negative bacteria.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5313-9.
1995: Georges Leclercq; Magda De Smedt; Jean Plum
Cytokine dependence of V gamma 3 thymocytes: mature but not immature V gamma 3 cells require endogenous IL-2 and IL-7 to survive--evidence for cytokine redundancy.
International immunology 1995;7(5):843-51.
1995: G Leclercq; Jean Plum
Expression and function of Fc receptors in the thymus.
Critical reviews in immunology 1995;15(3-4):215-33.
1994: Chris Verhofstede; S Reniers; F Van Wanzeele; Jean Plum
Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: correlation with virological and immunological markers of disease.
AIDS (London, England) 1994;8(10):1421-7.
1994: Georges Leclercq; Jean Plum
Developmentally ordered appearance of a functional Fc gamma receptor on TCR V gamma 3 thymocytes. Evidence for stimulation-induced expression.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2429-35.
1994: Jean Plum; Magda De Smedt; Marie-Paule Defresne; Georges Leclercq; Bart Vandekerckhove
Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.
Blood 1994;84(5):1587-93.
1994: Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Jean Plum
Human fetal liver cells differentiate into thymocytes in chimeric mouse fetal thymus organ culture.
Advances in experimental medicine and biology 1994;355():27-31.
1993: Chris Verhofstede; S Reniers; R Colebunders; F van Wanzeele; Jean Plum
Polymerase chain reaction in the diagnosis of Toxoplasma encephalitis.
AIDS (London, England) 1993;7(11):1539-41.
1993: G Leclercq; Jean Plum; D Nandi; M De Smedt; J P Allison
Intrathymic differentiation of V gamma 3 T cells.
The Journal of experimental medicine 1993;178(1):309-15.
1993: Jean Plum; M De Smedt; G Leclercq
Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):2706-16.
1992: G Leclercq; M De Smedt; Jean Plum
Cytokine production and responsiveness of fetal T-cell receptor V gamma 3 thymocytes.
Scandinavian journal of immunology 1992;36(6):833-41.
1992: G Leclercq; M De Smedt; Jean Plum
Presence of CD8 alpha-CD8 beta-positive TcR gamma/delta thymocytes in the fetal murine thymus and their in vitro expansion with interleukin-7.
European journal of immunology 1992;22(9):2189-93.
1992: A M Van den Abeele; L Van Renterghem; K Willems; Jean Plum
Prevalence of antibodies to Chlamydia pneumoniae in a Belgian population.
The Journal of infection 1992;25 Suppl 1():87-90.
1991: G Leclercq; M De Smedt; Jean Plum
Interleukin 4 induces CD8 alpha expression on T cell receptor V gamma 5 thymocytes.
European journal of immunology 1991;21(7):1751-4.
1991: Jean Plum; M De Smedt; A Billiau; H Heremans; G Leclercq; B Tison
IFN-gamma reverses IL-4 inhibition of fetal thymus growth in organ culture.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):50-4.
1991: G Leclercq; M De Smedt; Jean Plum
Interleukin-2 stimulated T cell receptor V gamma 3 positive thymocytes do not migrate to the skin.
Immunology letters 1991;28(2):135-41.
1991: S Vanderschueren; L Van Renterghem; Jean Plum; Chris Verhofstede; R Mak; J Vincke
Hepatitis C among risk groups for HIV and hepatitis B.
International journal of STD & AIDS 1991;2(3):185-7.
1991: R P Mak; Jean Plum
Do prostitutes need more health education regarding sexually transmitted diseases and the HIV infection? Experience in a Belgian city.
Social science & medicine (1982) 1991;33(8):963-6.
1990: G Leclercq; M De Smedt; B Tison; Jean Plum
Preferential proliferation of T cell receptor V gamma 3-positive cells in IL-2-stimulated fetal thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(12):3992-7.
1990: Chris Verhofstede; L Van Renterghem; Jean Plum
Evaluation of immunoblotting for the detection of Toxoplasma gondii immunoglobulin M antibodies.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1990;9(11):835-7.
1990: R Mak; Jean Plum; L Van Renterghem
Human immunodeficiency virus (HIV) infection, sexually transmitted diseases and HIV-antibody testing practices in Belgian prostitutes.
Genitourinary medicine 1990;66(5):337-41.
1990: G Leclercq; M De Smedt; Jean Plum
Direct evidence for partial target specificity in lymphokine-activated killer thymocytes.
Scandinavian journal of immunology 1990;32(4):373-9.
1990: Jean Plum; M De Smedt; G Leclercq; B Tison
Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(4):1066-73.
1990: Jean Plum; F Koning; G Leclercq; B Tison; M De Smedt
Expansion of large granular lymphocytes in IL-2-driven 14-day-old fetal thymocytes in organ culture.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3710-7.
1990: L Van Renterghem; A M Van den Abeele; Geert Claeys; Jean Plum
Prevalence of antibodies to Chlamydia pneumoniae in a pediatric hospital population in Belgium.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1990;9(5):347-9.
1989: Chris Verhofstede; L Van Renterghem; Jean Plum
Comparison of six commercial enzyme linked immunosorbent assays for detecting IgM antibodies against Toxoplasma gondii.
Journal of clinical pathology 1989;42(12):1285-90.
1989: Jean Plum; M de Smedt; B Tison; G Leclercq
Influence of antibodies neutralizing cytokines on murine fetal thymic organ cultures.
Thymus 1989;13(1-2):83-93.
1989: G Leclercq; M de Smedt; B Tison; Jean Plum
Analysis of the cytotoxic function of the thymocytes generated in a 14-day old mouse fetal thymus organ culture with high dose of IL-2.
Thymus 1989;13(1-2):95-102.
1988: Jean Plum; M De Smedt
Differentiation of thymocytes in fetal organ culture: lack of evidence for the functional role of the interleukin 2 receptor expressed by prothymocytes.
European journal of immunology 1988;18(5):795-9.
1988: Marie-Paule Defresne; Jean Plum; M De Smedt; Jacques Boniver
Enzyme analysis of thymic nurse cells.
Thymus 1988;11(4):221-30.
1988: Jean Plum; P Van Cauwenberge; M De Smedt
Detection of IL-2 receptor positive tonsillar lymphocytes by monoclonal antibody and protein A coated erythrocytes.
Immunology letters 1988;17(1):35-9.
1988: Jean Plum; P Van Cauwenberge; M De Smedt
Analysis of activation markers on tonsillar T lymphocytes.
Acta oto-laryngologica. Supplementum 1988;454():113-7.
1987: Jean Plum; M de Smedt
Analysis of human prenatal and postnatal thymocytes with the anti-Tac monoclonal antibody and recombinant interleukin-2.
Thymus 1987;9(3):149-58.
1986: Jean Plum; P Van Cauwenberge; M De Smedt
Human tonsillar T lymphocytes: an immature or activated T-lymphocyte population.
Clinical immunology and immunopathology 1986;39(1):14-23.
1986: Jean Plum; P Van Cauwenberge; M De Smedt
Phenotyping of mononuclear cells from tonsils and corresponding biopsies using a cytofluorimeter. A comparative study.
Acta oto-laryngologica 1986;101(1-2):129-34.
1985: D A Wulfrank; R C Vanholder; Jean Plum; A E De Schryver; S M Ringoir
Membrane plasma exchange in patients with metastatic cancer.
Journal of cancer research and clinical oncology 1985;110(3):230-3.
1984: I De Scheerder; D Wulfrank; L Van Renterghem; L Sabbe; D Robbrecht; D Clement; F Derom; Jean Plum; G Verdonk
Association of anti-heart antibodies and circulating immune complexes in the post-pericardiotomy syndrome.
Clinical and experimental immunology 1984;57(2):423-8.
1984: Jean Plum; M de Smedt; L Sabbe
Enzyme analysis of autologous rosette-forming cells.
Scandinavian journal of immunology 1984;19(3):199-204.
1984: Jean Plum; M De Smedt; L J Sabbe; J E De Roose
LDH analysis of human thymocytes and thymocyte subsets.
Journal of immunology (Baltimore, Md. : 1950) 1984;132(2):730-4.
1984: Jean Plum; P van Cauwenberge; M De Smedt
Analysis of lymphocytes in tonsils and blood from patients with chronic tonsillitis.
Acta oto-rhino-laryngologica Belgica 1984;38(6):632-7.
1984: Jean Plum; M De Smedt; L Sabbe
LDH isoenzyme distribution in human T gamma lymphocytes.
Immunology letters 1984;8(4):153-8.
1984: E Orye; Jean Plum; M De Smedt
Beta-glucuronidase activity in human T and B lymphocytes and the Tmu and T gamma subpopulations.
Histochemistry 1984;81(3):287-90.
1983: L Sabbe; Jean Plum; M De Smedt; G Leroux; Andries Louwagie; Arnold Criel
Cell-marker studies in CLL with monoclonal OKT antisera and lactic dehydrogenase isoenzyme analysis.
Blut 1983;46(5):261-70.
1982: Jean Plum; J Huys; Y De Scheerder; E Dhont; M De Smedt
Influence of nandrolone decanoate on the repopulation of the thymus after total body irradiation of mice.
Immunopharmacology 1982;5(1):19-30.
1980: Jean Plum; M De Smedt
Enzymatic relationship between human T gamma + lymphocytes and thymocytes.
Cellular immunology 1980;55(2):485-9.
1980: Werner P De Potter; N H Fraeyman; Jean Plum; A F De Schaepdryver
Immunohistochemical evidence for a plasma membrane localization of dopamine-beta-hydroxylase in the mouse neuroblastoma.
Tissue & cell 1980;12(2):227-32.
1979: Jean Plum; S Ringoir; M de Smedt
Lactate dehydrogenase isoenzyme pattern of the pre-thymic precursor cell.
Immunology 1979;37(4):817-20.
1978: Jean Plum; S Ringoir; M de Smedt; E Dhont
Lactate dehydrogenase isoenzymatic analysis of murine lymphocyte populations: a parameter of cellular differentiation.
Cellular immunology 1978;36(1):37-45.
1978: Jean Plum
Basic concepts in immunology.
Acta oto-rhino-laryngologica Belgica 1978;32(1):9-16.
1978: Jean Plum; R Monteyne; E Dhont; M De Smedt
Lactate dehydrogenase isoenzyme pattern: marker for differentiation of lymphocytes.
Scandinavian journal of immunology 1978;7(6):515-8.
1978: Jean Plum; M Thiery; L Sabbe
Distribution of mononuclear cells during pregnancy.
Clinical and experimental immunology 1978;31(1):45-9.
1977: Jean Plum; S Ringoir; M de Smedt
Lactic-dehydrogenase activity in thymocyte populations.
Lancet 1977;2(8040):721.
1977: Jean Plum; S Ringoir
Lactate dehydrogenase isoenzyme pattern as a measure of cellular differentiation in lymphocytic cells.
Journal of the Reticuloendothelial Society 1977;21(4):225-30.
1977: R A Mussche; Jean Plum; M de Smedt; P Kluyskens
Levamisole versus placebo as an adjunct to primary therapy of laryngopharyngeal epidermoid carcinoma. Evaluation of the immune status.
Acta oto-rhino-laryngologica Belgica 1977;31(6):566-77.
1975: S Ringoir; Jean Plum
LDH isozymes of human T and B lymphocytes.
Clinica chimica acta; international journal of clinical chemistry 1975;60(3):379-83.