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Gordon Roberts

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Benjamin T Goult; Alexandre R Gingras; Neil Bate; Igor L Barsukov; David R Critchley; Gordon Roberts
The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.
Benjamin T Goult; Mohamed Bouaouina; Paul R Elliott; Neil Bate; Bipin Patel; Alexandre R Gingras; J Günter Grossmann; Gordon Roberts; David A Calderwood; David R Critchley; Igor L Barsukov
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Jacqueline Ellis; Aldo Gutierrez; Igor L Barsukov; Wei-Cheng Huang; J Günter Grossmann; Gordon Roberts
Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.

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All Publications

2010: Benjamin T Goult; Alexandre R Gingras; Neil Bate; Igor L Barsukov; David R Critchley; Gordon Roberts
The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.
FEBS letters 2010;584(11):2237-41.
2010: Benjamin T Goult; Mohamed Bouaouina; Paul R Elliott; Neil Bate; Bipin Patel; Alexandre R Gingras; J Günter Grossmann; Gordon Roberts; David A Calderwood; David R Critchley; Igor L Barsukov
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
The EMBO journal 2010;29(6):1069-80.
2009: Jacqueline Ellis; Aldo Gutierrez; Igor L Barsukov; Wei-Cheng Huang; J Günter Grossmann; Gordon Roberts
Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.
The Journal of biological chemistry 2009;284(52):36628-37.
2009: Benjamin T Goult; Mohamed Bouaouina; David S Harburger; Neil Bate; Bipin Patel; Nicholas J Anthis; Iain D Campbell; David A Calderwood; Igor L Barsukov; Gordon Roberts; David R Critchley
The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.
Journal of molecular biology 2009;394(5):944-56.
2009: Olivier Jacquin; Dorothée Balbeur; Christian Damblon; Pierre Marchot; Edwin De Pauw; Gordon Roberts; Jean-Marie Frère; Alain Matagne
Positively cooperative binding of zinc ions to Bacillus cereus 569/H/9 beta-lactamase II suggests that the binuclear enzyme is the only relevant form for catalysis.
Journal of molecular biology 2009;392(5):1278-91.
2009: Benjamin T Goult; Neil Bate; Nicholas J Anthis; Kate L Wegener; Alexandre R Gingras; Bipin Patel; Igor L Barsukov; Iain D Campbell; Gordon Roberts; David R Critchley
The structure of an interdomain complex that regulates talin activity.
The Journal of biological chemistry 2009;284(22):15097-106.
2009: Alexandre R Gingras; Wolfgang H Ziegler; Andrey A Bobkov; M Gordon Joyce; Domenico Fasci; Mirko Himmel; Sven Rothemund; Anett Ritter; J Günter Grossmann; Bipin Patel; Neil Bate; Benjamin T Goult; Jonas Emsley; Igor L Barsukov; Gordon Roberts; Robert C Liddington; Mark H Ginsberg; David R Critchley
Structural determinants of integrin binding to the talin rod.
The Journal of biological chemistry 2009;284(13):8866-76.
2008: Yury Kapelyukh; Mark Paine; Jean-Didier Marechal; Michael J Sutcliffe; C Roland Wolf; Gordon Roberts
Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2136-44.
2008: Kate L Wegener; Jaswir Basran; Clive R Bagshaw; Iain D Campbell; Gordon Roberts; David R Critchley; Igor L Barsukov
Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.
Journal of molecular biology 2008;382(1):112-26.
2008: Benoît M R Liénard; Gianpiero Garau; Louise Horsfall; Andreas Ioannis Karsisiotis; Christian Damblon; Patricia Lassaux; Cyril Papamicael; Gordon Roberts; Moreno Galleni; Otto Dideberg; Jean-Marie Frère; Christopher J Schofield
Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.
Organic & biomolecular chemistry 2008;6(13):2282-94.
2008: Benjamin T Goult; Alexandre R Gingras; Neil Bate; Gordon Roberts; David R Critchley; Igor L Barsukov
NMR assignment of the C-terminal actin-binding domain of talin.
Biomolecular NMR assignments 2008;2(1):17-9.
2008: Jean-Didier Marechal; C A Kemp; Gordon Roberts; Mark Paine; C Roland Wolf; Michael J Sutcliffe
Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.
British journal of pharmacology 2008;153 Suppl 1():S82-9.
2008: Alexandre R Gingras; Neil Bate; Benjamin T Goult; Larnele Hazelwood; Ilona Canestrelli; J Günter Grossmann; HongJun Liu; Nicholas S M Putz; Gordon Roberts; Niels Volkmann; Dorit Hanein; Igor L Barsukov; David R Critchley
The structure of the C-terminal actin-binding domain of talin.
The EMBO journal 2008;27(2):458-69.
2007: Wei-Cheng Huang; Andrew C G Westlake; Jean-Didier Marechal; M Gordon Joyce; Peter C E Moody; Gordon Roberts
Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.
Journal of molecular biology 2007;373(3):633-51.
2006: Gordon Roberts
Folding and unfolding for binding: large-scale protein dynamics in protein-protein interactions.
Biochemical Society transactions 2006;34(Pt 5):971-4.
2006: Jinglei Yu; Mark Paine; Jean-Didier Marechal; Carol A Kemp; Clive J Ward; Simon Brown; Michael J Sutcliffe; Gordon Roberts; Elaine M Rankin; C Roland Wolf
In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1386-92.
2006: Jean-Didier Marechal; Jinglei Yu; Simon Brown; Iouri Kapelioukh; Elaine M Rankin; C Roland Wolf; Gordon Roberts; Mark Paine; Michael J Sutcliffe
In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):534-8.
2006: Bipin Patel; Alexandre R Gingras; Andrey A Bobkov; L Miya Fujimoto; Man Zhang; Robert C Liddington; Daniela Mazzeo; Jonas Emsley; Gordon Roberts; Igor L Barsukov; David R Critchley
The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.
The Journal of biological chemistry 2006;281(11):7458-67.
2006: Alexandre R Gingras; Klaus-Peter Vogel; Heinz-Jürgen Steinhoff; Wolfgang H Ziegler; Bipin Patel; Jonas Emsley; David R Critchley; Gordon Roberts; Igor L Barsukov
Structural and dynamic characterization of a vinculin binding site in the talin rod.
Biochemistry 2006;45(6):1805-17.
2005: Lesley A McLaughlin; Mark Paine; Carol A Kemp; Jean-Didier Marechal; Jack U Flanagan; Clive J Ward; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
The Journal of biological chemistry 2005;280(46):38617-24.
2005: Alexandre R Gingras; Wolfgang H Ziegler; Ronald Frank; Igor L Barsukov; Gordon Roberts; David R Critchley; Jonas Emsley
Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.
The Journal of biological chemistry 2005;280(44):37217-24.
2005: Ian J Fillingham; Alexandre R Gingras; Evangelos Papagrigoriou; Bipin Patel; Jonas Emsley; David R Critchley; Gordon Roberts; Igor L Barsukov
A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.
Structure (London, England : 1993) 2005;13(1):65-74.
2004: Carol A Kemp; Jack U Flanagan; Annamaria J van Eldik; Jean-Didier Marechal; C Roland Wolf; Gordon Roberts; Mark Paine; Michael J Sutcliffe
Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition.
Journal of medicinal chemistry 2004;47(22):5340-6.
2004: Evangelos Papagrigoriou; Alexandre R Gingras; Igor L Barsukov; Neil Bate; Ian J Fillingham; Bipin Patel; Ronald Frank; Wolfgang H Ziegler; Gordon Roberts; David R Critchley; Jonas Emsley
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.
The EMBO journal 2004;23(15):2942-51.
2004: Jack U Flanagan; Jean-Didier Marechal; Richard Ward; Carol A Kemp; Lesley A McLaughlin; Michael J Sutcliffe; Gordon Roberts; Mark Paine; C Roland Wolf
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
The Biochemical journal 2004;380(Pt 2):353-60.
2003: Igor L Barsukov; Andrew Prescot; Neil Bate; Bipin Patel; David N Floyd; Nina Bhanji; Clive R Bagshaw; Kresimir Letinic; Gilbert Di Paolo; Pietro De Camilli; Gordon Roberts; David R Critchley
Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain.
The Journal of biological chemistry 2003;278(33):31202-9.
2003: Christian Damblon; Mikael Jensen; Abdessamad Ababou; Igor Barsukov; Cyril Papamicael; Christopher J Schofield; Lars Olsen; Rogert Bauer; Gordon Roberts
The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding.
The Journal of biological chemistry 2003;278(31):29240-51.
2003: Aldo Gutierrez; Andrew W Munro; Alex Grunau; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues.
European journal of biochemistry / FEBS 2003;270(12):2612-21.
2003: Aldo Gutierrez; Alex Grunau; Mark Paine; Andrew W Munro; C Roland Wolf; Gordon Roberts; Nigel S Scrutton
Electron transfer in human cytochrome P450 reductase.
Biochemical Society transactions 2003;31(Pt 3):497-501.
2003: Jack U Flanagan; Lesley A McLaughlin; Mark Paine; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.
The Biochemical journal 2003;370(Pt 3):921-6.
2003: Karl J Hale; Mark Frigerio; Soraya Manaviazar; Marc G Hummersone; Ian J Fillingham; Igor Barsukov; Christian Damblon; Andreas J Gescher; Gordon Roberts
Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process.
Organic letters 2003;5(4):499-502.
2003: Mark Paine; Lesley A McLaughlin; Jack U Flanagan; Carol A Kemp; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.
The Journal of biological chemistry 2003;278(6):4021-7.
2002: Keith McLuckie; Michael Routledge; Karen Brown; Margaret Gaskell; Peter B Farmer; Gordon Roberts; Elizabeth A Martin
DNA adducts formed from 4-hydroxytamoxifen are more mutagenic than those formed by alpha-acetoxytamoxifen in a shuttle vector target gene replicated in human Ad293 cells.
Biochemistry 2002;41(28):8899-906.
2002: Aldo Gutierrez; Mark Paine; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.
Biochemistry 2002;41(14):4626-37.
2001: C Mollard; Catherine Moali; Cyril Papamicael; Christian Damblon; sandrine vessillier; Gianfranco Amicosante; Christopher J Schofield; Moreno Galleni; Jean-Marie Frere; Gordon Roberts
Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies.
The Journal of biological chemistry 2001;276(48):45015-23.
2001: Mark Paine; S Ayivor; Alastair Munro; P Tsan; Lu-Yun Lian; Gordon Roberts; C Roland Wolf
Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity.
Biochemistry 2001;40(45):13439-47.
2001: Lars Hemmingsen; Christian Damblon; Jens Antony; M Jensen; Hans-Werner Adolph; Sandra Wommer; Gordon Roberts; Rogert Bauer
Dynamics of mononuclear cadmium beta-lactamase revealed by the combination of NMR and PAC spectroscopy.
Journal of the American Chemical Society 2001;123(42):10329-35.
2001: Alexander P Golovanov; D Hawkins; Igor Barsukov; R Badii; Gary M Bokoch; Lu-Yun Lian; Gordon Roberts
Structural consequences of site-directed mutagenesis in flexible protein domains: NMR characterization of the L(55,56)S mutant of RhoGDI.
European journal of biochemistry / FEBS 2001;268(8):2253-60.
2001: Aldo Gutierrez; Lu-Yun Lian; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains.
Biochemistry 2001;40(7):1964-75.
2001: Alexander P Golovanov; Tsung-Hsien Chuang; Céline DerMardirossian; Igor Barsukov; D Hawkins; R Badii; Gary M Bokoch; Lu-Yun Lian; Gordon Roberts
Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI.
Journal of molecular biology 2001;305(1):121-35.
2001: O Döhr; Mark Paine; Thomas Friedberg; Gordon Roberts; C Roland Wolf
Engineering of a functional human NADH-dependent cytochrome P450 system.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):81-6.
2000: Aldo Gutierrez; O Doehr; Mark Paine; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the soluble W676H and W676A mutant reductases.
Biochemistry 2000;39(51):15990-9.
2000: Boyan B Bonev; W C Chan; Barrie W Bycroft; Gordon Roberts; Anthony Watts
Interaction of the lantibiotic nisin with mixed lipid bilayers: a 31P and 2H NMR study.
Biochemistry 2000;39(37):11425-33.
2000: Lu-Yun Lian; Igor Barsukov; Alexander P Golovanov; D I Hawkins; R Badii; Kong Hung SZE; Nicholas H Keep; Gary M Bokoch; Gordon Roberts
Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.
Structure (London, England : 1993) 2000;8(1):47-55.
1999: C S Allardyce; PD McDonagh; Lu-Yun Lian; C Roland Wolf; Gordon Roberts
The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathione S-transferases.
The Biochemical journal 1999;343 Pt 3():525-31.
1999: Gordon Roberts
The power of evolution: accessing the synthetic potential of P450s.
Chemistry & biology 1999;6(10):R269-72.
1999: Marco G Casarotto; Jaswir Basran; R Badii; Kong Hung SZE; Gordon Roberts
Direct measurement of the pKa of aspartic acid 26 in Lactobacillus casei dihydrofolate reductase: implications for the catalytic mechanism.
Biochemistry 1999;38(25):8038-44.
1999: PD McDonagh; David J Judah; John D Hayes; Lu-Yun Lian; GE Neal; C Roland Wolf; Gordon Roberts
Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases.
The Biochemical journal 1999;339 ( Pt 1)():95-101.
1999: Q Zhao; S Modi; Gilliam Smith; Mark Paine; PD McDonagh; C Roland Wolf; D Tew; Lu-Yun Lian; Gordon Roberts; H P Driessen
Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.
Protein science : a publication of the Protein Society 1999;8(2):298-306.
1999: Gordon Roberts
NMR spectroscopy in structure-based drug design.
Current opinion in biotechnology 1999;10(1):42-7.
1998: Gilliam Smith; S Modi; I Pillai; Lu-Yun Lian; Michael J Sutcliffe; Michael P Pritchard; Thomas Friedberg; Gordon Roberts; C Roland Wolf
Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
The Biochemical journal 1998;331 ( Pt 3)():783-92.
1998: AR Gargaro; A Soteriou; Thomas A Frenkiel; C J Bauer; Berry Birdsall; Vladimir Polshakov; Igor L Barsukov; Gordon Roberts; James Feeney
The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate.
Journal of molecular biology 1998;277(1):119-34.
1997: P M Kilby; Linda Van Eldik; Gordon Roberts
Identification of the binding site on S100B protein for the actin capping protein CapZ.
Protein science : a publication of the Protein Society 1997;6(12):2494-503.
1997: P Besse; S Modi; J M Boyle; Gordon Roberts; WU Primrose
Redox cycling by cytochrome P-450.
Biochemical Society transactions 1997;25(4):S579.
1997: C F Oliver; S Modi; WU Primrose; Lu-Yun Lian; Gordon Roberts
Engineering the substrate specificity of Bacillus megaterium cytochrome P-450 BM3: hydroxylation of alkyl trimethylammonium compounds.
The Biochemical journal 1997;327 ( Pt 2)():537-44.
1997: Jaswir Basran; Marco G Casarotto; Amrik Basran; Gordon Roberts
Effects of single-residue substitutions on negative cooperativity in ligand binding to dihydrofolate reductase.
Protein engineering 1997;10(7):815-26.
1997: Igor Barsukov; S Modi; Lu-Yun Lian; Kong Hung SZE; Mark Paine; C Roland Wolf; Gordon Roberts
1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase.
Journal of biomolecular NMR 1997;10(1):63-75.
1997: Nicholas H Keep; M Barnes; Igor Barsukov; R Badii; Lu-Yun Lian; Anthony W Segal; Peter C E Moody; Gordon Roberts
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.
Structure (London, England : 1993) 1997;5(5):623-33.
1997: S Modi; David Gilham; Michael J Sutcliffe; Lu-Yun Lian; WU Primrose; C Roland Wolf; Gordon Roberts
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: allosteric effects of NADPH-cytochrome P450 reductase.
Biochemistry 1997;36(15):4461-70.
1997: chandra verma; Leo S D Caves; Roderick E Hubbard; Gordon Roberts
Domain motions in dihydrofolate reductase: a molecular dynamics study.
Journal of molecular biology 1997;266(4):776-96.
1997: K K Khan; S Mazumdar; S Modi; M Sutcliffe; Gordon Roberts; S Mitra
Steady-state and picosecond-time-resolved fluorescence studies on the recombinant heme domain of Bacillus megaterium cytochrome P-450.
European journal of biochemistry / FEBS 1997;244(2):361-70.
1997: C F Oliver; S Modi; Michael J Sutcliffe; WU Primrose; Lu-Yun Lian; Gordon Roberts
A single mutation in cytochrome P450 BM3 changes substrate orientation in a catalytic intermediate and the regiospecificity of hydroxylation.
Biochemistry 1997;36(7):1567-72.
1997: Berry Birdsall; Marco G Casarotto; H T Cheung; Jaswir Basran; Gordon Roberts; James Feeney
The influence of aspartate 26 on the tautomeric forms of folate bound to Lactobacillus casei dihydrofolate reductase.
FEBS letters 1997;402(2-3):157-61.
1997: David Gilham; W Cairns; Mark Paine; S Modi; R Poulsom; Gordon Roberts; C Roland Wolf
Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(1):111-25.
1997: GN Moll; J Clark; W C Chan; Barrie W Bycroft; Gordon Roberts; Wil N Konings; Arnold J M Driessen
Role of transmembrane pH gradient and membrane binding in nisin pore formation.
Journal of bacteriology 1997;179(1):135-40.
1996: Igor Barsukov; Lu-Yun Lian; J Ellis; Kong Hung SZE; William V Shaw; Gordon Roberts
The conformation of coenzyme A bound to chloramphenicol acetyltransferase determined by transferred NOE experiments.
Journal of molecular biology 1996;262(4):543-58.
1996: P M Kilby; Linda Van Eldik; Gordon Roberts
The solution structure of the bovine S100B protein dimer in the calcium-free state.
Structure (London, England : 1993) 1996;4(9):1041-52.
1996: Gordon Roberts
The other kind of biological NMR--studies of enzyme-substrate interactions.
Neurochemical research 1996;21(9):1117-24.
1996: Helen M Dodd; Nikki Horn; W C Chan; C J Giffard; Barrie W Bycroft; Gordon Roberts; Michael J Gasson
Molecular analysis of the regulation of nisin immunity.
Microbiology (Reading, England) 1996;142 ( Pt 9)():2385-92.
1996: W C Chan; Helen M Dodd; Nikki Horn; K Maclean; Lu-Yun Lian; Barrie W Bycroft; Michael J Gasson; Gordon Roberts
Structure-activity relationships in the peptide antibiotic nisin: role of dehydroalanine 5.
Applied and environmental microbiology 1996;62(8):2966-9.
1996: W C Chan; M Leyland; J Clark; Helen M Dodd; Lu-Yun Lian; Michael J Gasson; Barrie W Bycroft; Gordon Roberts
Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin.
FEBS letters 1996;390(2):129-32.
1996: S Modi; Michael J Sutcliffe; WU Primrose; Lu-Yun Lian; Gordon Roberts
The catalytic mechanism of cytochrome P450 BM3 involves a 6 A movement of the bound substrate on reduction.
Nature structural biology 1996;3(5):414-7.
1996: S Modi; Mark Paine; Michael J Sutcliffe; Lu-Yun Lian; WU Primrose; C Roland Wolf; Gordon Roberts
A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.
Biochemistry 1996;35(14):4540-50.
1996: Mark Paine; D Gilham; Gordon Roberts; C Roland Wolf
Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.
Archives of biochemistry and biophysics 1996;328(1):143-50.
1996: C Damblon; X Raquet; L Y Lian; Josette Lamotte-Brasseur; E Fonze; Paulette Charlier; Gordon Roberts; Jean-Marie Frère
The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):1747-52.
1996: Q Zhao; G Smith; S Modi; Mark Paine; R C Wolf; D Tew; Lu-Yun Lian; WU Primrose; Gordon Roberts; H P Driessen
Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase.
Journal of structural biology 1996;116(2):320-5.
1996: G N Moll; Gordon Roberts; Wil N Konings; Arnold J M Driessen
Mechanism of lantibiotic-induced pore-formation.
Antonie van Leeuwenhoek 1996;69(2):185-91.
1996: V Ramesh; S E Syed; R O Frederick; Michael J Sutcliffe; M Barnes; Gordon Roberts
NMR studies of the mode of binding of corepressors and inducers to Escherichia coli trp repressor.
European journal of biochemistry / FEBS 1996;235(3):804-13.
1995: S Modi; WU Primrose; Lu-Yun Lian; Gordon Roberts
Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P-450 BM-3 on substrate binding and catalytic activity.
The Biochemical journal 1995;310 ( Pt 3)():939-43.
1995: S Modi; Lu-Yun Lian; Gordon Roberts; G C Smith; Mark Paine; C Roland Wolf
Structural studies on FMN domain of cytochrome P450 reductase.
Biochemical Society transactions 1995;23(3):476S.
1995: S Modi; WU Primrose; J M Boyle; C F Gibson; Lu-Yun Lian; Gordon Roberts
NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam.
Biochemistry 1995;34(28):8982-8.
1995: R Badii; Jaswir Basran; Marco G Casarotto; Gordon Roberts
High-level expression and isotopic labeling of Lactobacillus casei dihydrofolate reductase for nuclear magnetic resonance spectroscopy.
Protein expression and purification 1995;6(3):237-43.
1995: P M Kilby; Linda Van Eldik; Gordon Roberts
Nuclear magnetic resonance assignments and secondary structure of bovine S100 beta protein.
FEBS letters 1995;363(1-2):90-6.
1995: V Ramesh; Y Z Xu; Gordon Roberts
Site-specific 15N-labelling of oligonucleotides for NMR: the trp operator and its interaction with the trp repressor.
FEBS letters 1995;363(1-2):61-4.
1995: R M Bellingham; A H Gibbs; F de Matteis; Lu-Yun Lian; Gordon Roberts
Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice.
The Biochemical journal 1995;307 ( Pt 2)():505-12.
1995: Jaswir Basran; Marco G Casarotto; Igor Barsukov; Gordon Roberts
Role of the active-site carboxylate in dihydrofolate reductase: kinetic and spectroscopic studies of the aspartate 26-->asparagine mutant of the Lactobacillus casei enzyme.
Biochemistry 1995;34(9):2872-82.
1995: P M Kilby; WU Primrose; Gordon Roberts
Changes in the structure of bovine phospholipase A2 upon micelle binding.
The Biochemical journal 1995;305 ( Pt 3)():935-44.
1995: R P Glover; G M Sweetman; Peter B Farmer; Gordon Roberts
Sequencing of oligonucleotides using high performance liquid chromatography and electrospray mass spectrometry.
Rapid communications in mass spectrometry : RCM 1995;9(10):897-901.
1994: V Ramesh; R O Frederick; S E Syed; C F Gibson; J C Yang; Gordon Roberts
The interactions of Escherichia coli trp repressor with tryptophan and with an operator oligonucleotide. NMR studies using selectively 15N-labelled protein.
European journal of biochemistry / FEBS 1994;225(2):601-8.
1994: M Jamin; C Damblon; A M Bauduin-Misselyn; F Durant; Gordon Roberts; Paulette Charlier; G Llabres; Jean-Marie Frère
Direct n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase.
The Biochemical journal 1994;301 ( Pt 1)():199-203.
1994: J A Thomas; J R Arnold; Jaswir Basran; J Andrews; Gordon Roberts; Berry Birdsall; James Feeney
Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase.
Protein engineering 1994;7(6):783-92.
1994: Lu-Yun Lian; Igor Barsukov; J P Derrick; Gordon Roberts
Mapping the interactions between streptococcal protein G and the Fab fragment of IgG in solution.
Nature structural biology 1994;1(6):355-7.
1994: Lu-Yun Lian; Igor Barsukov; Michael J Sutcliffe; Kong Hung SZE; Gordon Roberts
Protein-ligand interactions: exchange processes and determination of ligand conformation and protein-ligand contacts.
Methods in enzymology 1994;239():657-700.
1993: J P Derrick; Dale B Wigley; Lu-Yun Lian; Michael J Sutcliffe; J C Yang; P D Dawson; Gordon Roberts
Structure and mechanism of streptococcal protein G.
Biochemical Society transactions 1993;21(4):333S.
1993: David J Judah; J D Hayes; J C Yang; Lu-Yun Lian; Gordon Roberts; P B Farmer; J H Lamb; GE Neal
A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant.
The Biochemical journal 1993;292 ( Pt 1)():13-8.
1993: W C Chan; Barrie W Bycroft; M L Leyland; Lu-Yun Lian; Gordon Roberts
A novel post-translational modification of the peptide antibiotic subtilin: isolation and characterization of a natural variant from Bacillus subtilis A.T.C.C. 6633.
The Biochemical journal 1993;291 ( Pt 1)():23-7.
1992: Lu-Yun Lian; J P Derrick; Michael J Sutcliffe; J C Yang; Gordon Roberts
Determination of the solution structures of domains II and III of protein G from Streptococcus by 1H nuclear magnetic resonance.
Journal of molecular biology 1992;228(4):1219-34.
1992: P K Slaich; WU Primrose; D H Robinson; Christopher W Wharton; A J White; K Drabble; Gordon Roberts
The binding of amide substrate analogues to phospholipase A2. Studies by 13C-nuclear-magnetic-resonance and infrared spectroscopy.
The Biochemical journal 1992;288 ( Pt 1)():167-73.
1992: J P Derrick; Lu-Yun Lian; Gordon Roberts; William V Shaw
Analysis of the binding of 1,3-diacetylchloramphenicol to chloramphenicol acetyltransferase by isotope-edited 1H NMR and site-directed mutagenesis.
Biochemistry 1992;31(35):8191-5.
1992: C Bennion; S Connolly; N P Gensmantel; C Hallam; C G Jackson; W U Primrose; Gordon Roberts; D H Robinson; P K Slaich
Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex.
Journal of medicinal chemistry 1992;35(16):2939-51.
1992: Lu-Yun Lian; W C Chan; David Morley; Gordon Roberts; Barrie W Bycroft; D Jackson
Solution structures of nisin A and its two major degradation products determined by n.m.r.
The Biochemical journal 1992;283 ( Pt 2)():413-20.
1992: W C Chan; Barrie W Bycroft; M L Leyland; Lu-Yun Lian; J C Yang; Gordon Roberts
Sequence-specific resonance assignment and conformational analysis of subtilin by 2D NMR.
FEBS letters 1992;300(1):56-62.
1991: Eva I Hyde; V Ramesh; R Frederick; Gordon Roberts
NMR studies of the activation of the Escherichia coli trp repressor.
European journal of biochemistry / FEBS 1991;201(3):569-79.
1991: Mark D Carr; Berry Birdsall; Thomas A Frenkiel; C J Bauer; J Jimenez-Barbero; Vladimir Polshakov; J E McCormick; Gordon Roberts; James Feeney
Dihydrofolate reductase: sequential resonance assignments using 2D and 3D NMR and secondary structure determination in solution.
Biochemistry 1991;30(25):6330-41.
1991: Lu-Yun Lian; J C Yang; J P Derrick; Michael J Sutcliffe; Gordon Roberts; J P Murphy; C R Goward; T Atkinson
Sequential 1H NMR assignments and secondary structure of an IgG-binding domain from protein G.
Biochemistry 1991;30(22):5335-40.
1991: J P Derrick; Lu-Yun Lian; Gordon Roberts; William V Shaw
Identification of the C2-1H histidine NMR resonances in chloramphenicol acetyltransferase by a 13C-1H heteronuclear multiple quantum coherence method.
FEBS letters 1991;280(1):125-8.
1991: Gordon Roberts
Conformational flexibility and protein specificity.
Ciba Foundation symposium 1991;158():169-82; discussion 182-6, 204-12.
1990: Berry Birdsall; S J Tendler; J R Arnold; James Feeney; R J Griffin; Mark D Carr; J A Thomas; Gordon Roberts; M F Stevens
NMR studies of multiple conformations in complexes of Lactobacillus casei dihydrofolate reductase with analogues of pyrimethamine.
Biochemistry 1990;29(41):9660-7.
1990: Berry Birdsall; J R Arnold; J Jimenez-Barbero; Thomas A Frenkiel; C J Bauer; S J Tendler; Mark D Carr; J A Thomas; Gordon Roberts; James Feeney
The 1H-NMR assignments of the aromatic resonances in complexes of Lactobacillus casei dihydrofolate reductase and the origins of their chemical shifts.
European journal of biochemistry / FEBS 1990;191(3):659-68.
1989: Eva I Hyde; V Ramesh; Gordon Roberts; Cheryl H Arrowsmith; L Treat-Clemons; B Klaic; O Jardetzky
NMR studies of the Escherichia coli trp aporepressor. Sequence-specific assignment of the aromatic proton resonances.
European journal of biochemistry / FEBS 1989;183(3):545-53.
1989: M A Jimenez; J R Arnold; J Andrews; J A Thomas; Gordon Roberts; Berry Birdsall; James Feeney
Dihydrofolate reductase: control of the mode of substrate binding by aspartate 26.
Protein engineering 1989;2(8):627-31.
1989: J Fisher; WU Primrose; Gordon Roberts; Nick Dekker; Rolf Boelens; Robert Kaptein; AJ Slotboom
1H NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution.
Biochemistry 1989;28(14):5939-46.
1989: J Andrews; Carol A Fierke; Berry Birdsall; G Ostler; James Feeney; Gordon Roberts; Stephen J Benkovic
A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei.
Biochemistry 1989;28(14):5743-50.
1989: Gordon Roberts
N.m.r. studies of coenzyme binding to Lactobacillus casei dihydrofolate reductase.
Biochemical Society transactions 1989;17(2):297-9.
1989: Berry Birdsall; James Feeney; S J Tendler; S J Hammond; Gordon Roberts
Dihydrofolate reductase: multiple conformations and alternative modes of substrate binding.
Biochemistry 1989;28(5):2297-305.
1989: K Bowden; A D Hall; B Birdsall; J Feeney; Gordon Roberts
Interactions between inhibitors of dihydrofolate reductase.
The Biochemical journal 1989;258(2):335-42.
1989: Berry Birdsall; J Andrews; G Ostler; S J Tendler; James Feeney; Gordon Roberts; Roger Wayne Davies; H T Cheung
NMR studies of differences in the conformations and dynamics of ligand complexes formed with mutant dihydrofolate reductases.
Biochemistry 1989;28(3):1353-62.
1989: Q X Hua; Y J Chen; C C Wang; D C Wang; Gordon Roberts
High resolution 1H-NMR studies of Des-(B26-B30)-insulin; assignment of resonances and properties of aromatic residues.
Biochimica et biophysica acta 1989;994(2):114-20.
1988: Gordon Roberts
Molecular recognition by dihydrofolate reductase: n.m.r. studies of protein-ligand interactions.
Biochemical Society transactions 1988;16(6):925-7.
1988: S J Tendler; R J Griffin; Berry Birdsall; M F Stevens; Gordon Roberts; James Feeney
Direct 19F NMR observation of the conformational selection of optically active rotamers of the antifolate compound fluoronitropyrimethamine bound to the enzyme dihydrofolate reductase.
FEBS letters 1988;240(1-2):201-4.
1988: M S Searle; M J Forster; Berry Birdsall; Gordon Roberts; James Feeney; H T Cheung; I Kompis; A J Geddes
Dynamics of trimethoprim bound to dihydrofolate reductase.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3787-91.
1987: S J Hammond; Berry Birdsall; James Feeney; M S Searle; Gordon Roberts; H T Cheung
Structural comparisons of complexes of methotrexate analogues with Lactobacillus casei dihydrofolate reductase by two-dimensional 1H NMR at 500 MHz.
Biochemistry 1987;26(26):8585-90.
1987: Gordon Roberts
Dihydrofolate reductase: specificity and conformational change.
Biochemical Society transactions 1987;15(4):762-6.
1987: Berry Birdsall; J De Graw; James Feeney; S Hammond; M S Searle; Gordon Roberts; WT Colwell; J Crase
15N and 1H NMR evidence for multiple conformations of the complex of dihydrofolate reductase with its substrate, folate.
FEBS letters 1987;217(1):106-10.
1986: H T Cheung; M S Searle; James Feeney; Berry Birdsall; Gordon Roberts; I Kompis; S J Hammond
Trimethoprim binding to Lactobacillus casei dihydrofolate reductase: a 13C NMR study using selectively 13C-enriched trimethoprim.
Biochemistry 1986;25(8):1925-31.
1986: A D Waldman; B Birdsall; Gordon Roberts; J John Holbrook
13C-NMR and transient kinetic studies on lactate dehydrogenase [Cys(13CN)165]. Direct measurement of a rate-limiting rearrangement in protein structure.
Biochimica et biophysica acta 1986;870(1):102-11.
1986: S J Hammond; Berry Birdsall; M S Searle; Gordon Roberts; James Feeney
Dihydrofolate reductase. 1H resonance assignments and coenzyme-induced conformational changes.
Journal of molecular biology 1986;188(1):81-97.
1986: M S Searle; S J Hammond; Berry Birdsall; Gordon Roberts; James Feeney; R W King; D V Griffiths
Identification of the 1H resonances of valine and leucine residues in dihydrofolate reductase by using a combination of selective deuteration and two-dimensional correlation spectroscopy.
FEBS letters 1986;194(1):165-70.
1985: M C Griffin; Gordon Roberts
A 1H-n.m.r. study of casein micelles.
The Biochemical journal 1985;228(1):273-6.
1985: A W Bevan; Gordon Roberts; James Feeney; L Kuyper
1H and 15N NMR studies of protonation and hydrogen-bonding in the binding of trimethoprim to dihydrofolate reductase.
European biophysics journal : EBJ 1985;11(4):211-8.
1984: Berry Birdsall; James Feeney; C Pascual; Gordon Roberts; I Kompis; Rudolf L Then; K Müller; A Kroehn
A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase.
Journal of medicinal chemistry 1984;27(12):1672-6.
1984: Berry Birdsall; James Feeney; D V Griffiths; S Hammond; B Kimber; R W King; Gordon Roberts; M Searle
The combined use of selective deuteration and double resonance experiments in assigning the 1H resonances of valine and tyrosine residues of dihydrofolate reductase.
FEBS letters 1984;175(2):364-8.
1984: Berry Birdsall; A W Bevan; C Pascual; Gordon Roberts; James Feeney; A Gronenborn; G M Clore
Multinuclear NMR characterization of two coexisting conformational states of the Lactobacillus casei dihydrofolate reductase-trimethoprim-NADP+ complex.
Biochemistry 1984;23(20):4733-42.
1984: G M Clore; A M Gronenborn; B Birdsall; James Feeney; Gordon Roberts
19F-n.m.r. studies of 3',5'-difluoromethotrexate binding to Lactobacillus casei dihydrofolate reductase. Molecular motion and coenzyme-induced conformational changes.
The Biochemical journal 1984;217(3):659-66.
1984: D J Antonjuk; Berry Birdsall; H T Cheung; G M Clore; James Feeney; A Gronenborn; Gordon Roberts; T Q Tran
A 1H n.m.r. study of the role of the glutamate moiety in the binding of methotrexate to Lactobacillus casei dihydrofolate reductase.
British journal of pharmacology 1984;81(2):309-15.
1984: L C Packman; R N Perham; Gordon Roberts
Domain structure and 1H-n.m.r. spectroscopy of the pyruvate dehydrogenase complex of Bacillus stearothermophilus.
The Biochemical journal 1984;217(1):219-27.
1984: G Maghuin-Rogister; Francis Frankenne; M Horward-Poncelet; Gordon Roberts
[Identification of an active site in luteotropin (LH) and chorionic gonadotropin (CG) based on studies of their conformation in solution by proton nuclear magnetic resonance (NMR) and on the receptor-binding properties of hormone fragments].
Annales d'endocrinologie 1984;45(4-5):257-60.
1983: R M Thomas; James Feeney; R B Nicholson; R H Pain; Gordon Roberts
Identification by n.m.r. spectroscopy of a stable intermediate structure in the unfolding of staphylococcal beta-lactamase.
The Biochemical journal 1983;215(3):525-9.
1983: Berry Birdsall; Gordon Roberts; James Feeney; J G Dann; A S Burgen
Trimethoprim binding to bacterial and mammalian dihydrofolate reductase: a comparison by proton and carbon-13 nuclear magnetic resonance.
Biochemistry 1983;22(24):5597-604.
1983: A N Barrett; Gordon Roberts; A S Burgen; G M Clore
Ab initio molecular orbital calculations of electron distribution in tetramethylammonium ion.
Molecular pharmacology 1983;24(3):443-8.
1983: B Birdsall; R W King; M R Wheeler; C A Lewis; S R Goode; R B Dunlap; Gordon Roberts
Correction for light absorption in fluorescence studies of protein-ligand interactions.
Analytical biochemistry 1983;132(2):353-61.
1983: M Stewart; Gordon Roberts
Nuclear magnetic resonance evidence for a flexible region at the C-terminus of alpha-tropomyosin.
Journal of molecular biology 1983;166(2):219-25.
1983: R W Woody; D C Clark; Gordon Roberts; S R Martin; P M Bayley
Molecular flexibility in microtubule proteins: proton nuclear magnetic resonance characterization.
Biochemistry 1983;22(9):2186-92.
1983: James Feeney; Berry Birdsall; Gordon Roberts; A S Burgen
Use of transferred nuclear Overhauser effect measurements to compare binding of coenzyme analogues to dihydrofolate reductase.
Biochemistry 1983;22(3):628-33.
1983: Francis Frankenne; G Maghuin-Rogister; B Birdsall; Gordon Roberts
H-NMR studies of the histidine residues of human choriogonadotropin and its alpha- and beta-subunits.
FEBS letters 1983;151(2):197-200.
1983: Gordon Roberts; H W Duckworth; L C Packman; R N Perham
Mobility and active-site coupling in 2-oxo acid dehydrogenase complexes.
Ciba Foundation symposium 1983;93():47-71.
1982: T E Mansour; P G Morris; James Feeney; Gordon Roberts
A 31P-nmr study of the intact liver fluke Fasciola hepatica.
Biochimica et biophysica acta 1982;721(4):336-40.
1982: Berry Birdsall; A Gronenborn; E I Hyde; G M Clore; Gordon Roberts; James Feeney; A S Burgen
Hydrogen-1, carbon-13, and phosphorus-31 nuclear magnetic resonance studies of the dihydrofolate reductase-nicotinamide adenine dinucleotide phosphate-folate complex: characterization of three coexisting conformational states.
Biochemistry 1982;21(23):5831-8.
1982: L C Packman; R N Perham; Gordon Roberts
Cross-linking and 1H n.m.r. spectroscopy of the pyruvate dehydrogenase complex of Escherichia coli.
The Biochemical journal 1982;205(2):389-96.
1982: R W Woody; Gordon Roberts; D C Clark; P M Bayley
1H NMR evidence for flexibility in microtubule-associated proteins and microtubule protein oligomers.
FEBS letters 1982;141(2):181-4.
1982: H W Duckworth; R Jaenicke; R N Perham; A O Wilkie; J T Finch; Gordon Roberts
Limited proteolysis and proton NMR spectroscopy of Bacillus stearothermophilus pyruvate dehydrogenase multienzyme complex.
European journal of biochemistry / FEBS 1982;124(1):63-9.
1981: Berry Birdsall; A S Burgen; E I Hyde; Gordon Roberts; James Feeney
Negative cooperativity between folinic acid and coenzyme in their binding to Lactobacillus casei dihydrofolate reductase.
Biochemistry 1981;20(25):7186-95.
1981: R N Perham; Gordon Roberts
Limited proteolysis and proton n.m.r. spectroscopy of the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli.
The Biochemical journal 1981;199(3):733-40.
1981: Berry Birdsall; A Gronenborn; G M Clore; Gordon Roberts; James Feeney; A S Burgen
13C NMR evidence for three slowly interconverting conformations of the dihydrofolate reductase-NADP+-folate complex.
Biochemical and biophysical research communications 1981;101(4):1139-44.
1981: E J Wawrzynczak; R N Perham; Gordon Roberts
Conformational mobility of polypeptide chains in the 2-oxo acid dehydrogenase complexes from ox heart revealed by proton NMR spectroscopy.
FEBS letters 1981;131(1):151-4.
1981: Gordon Roberts; James Feeney; A S Burgen; S Daluge
The charge state of trimethoprim bound to Lactobacillus casei dihydrofolate reductase.
FEBS letters 1981;131(1):85-8.
1981: R N Perham; H W Duckworth; Gordon Roberts
Mobility of polypeptide chain in the pyruvate dehydrogenase complex revealed by proton NMR.
Nature 1981;292(5822):474-7.
1981: D M Parker; J J Holbrook; B Birdsall; Gordon Roberts
H NMR studies of Tyr-237 of lactate dehydrogenase.
FEBS letters 1981;129(1):33-5.
1981: James Feeney; Berry Birdsall; J P Albrand; Gordon Roberts; A S Burgen; P A Charlton; D W Young
Hydrogen-1 nuclear magnetic resonance study of the complexes of two diastereoisomers of folinic acid with dihydrofolate reductase.
Biochemistry 1981;20(7):1837-42.
1981: A Gronenborn; Berry Birdsall; E I Hyde; Gordon Roberts; James Feeney; A S Burgen
Effects of coenzyme binding on histidine residues of Lactobacillus casei dihydrofolate reductase.
Biochemistry 1981;20(7):1717-22.
1980: Berry Birdsall; James Feeney; Gordon Roberts; A S Burgen
The use of saturation transfer NMR experiments to monitor the conformational selection accompanying ligand-protein interactions.
FEBS letters 1980;120(1):107-9.
1980: D R Phillips; Gordon Roberts
Proton nuclear magnetic resonance study of the self-complementary hexanucleotide d(pTpA)3 and its interaction with daunomycin.
Biochemistry 1980;19(21):4795-801.
1980: Berry Birdsall; A Gronenborn; E I Hyde; Gordon Roberts; James Feeney; A S Burgen
Demonstration and characterization of two co-existing conformations of an enzyme complex by n.m.r.
Biochemical Society transactions 1980;8(5):637.
1980: E I Hyde; Berry Birdsall; Gordon Roberts; James Feeney; A S Burgen
Phosphorus-31 nuclear magnetic resonance studies of the binding of oxidized coenzymes to Lactobacillus casei dihydrofolate reductase.
Biochemistry 1980;19(16):3746-54.
1980: E I Hyde; Berry Birdsall; Gordon Roberts; James Feeney; A S Burgen
Proton nuclear magnetic resonance saturation transfer studies of coenzyme binding to Lactobacillus casei dihydrofolate reductase.
Biochemistry 1980;19(16):3738-46.
1980: Berry Birdsall; A S Burgen; Gordon Roberts
Effects of coenzyme analogues on the binding of p-aminobenzoyl-L-glutamate and 2,4-diaminopyrimidine to Lactobacillus casei dihydrofolate reductase.
Biochemistry 1980;19(16):3732-7.
1980: Berry Birdsall; A S Burgen; Gordon Roberts
Binding of coenzyme analogues to Lactobacillus casei dihydrofolate reductase: binary and ternary complexes.
Biochemistry 1980;19(16):3723-31.
1980: Gordon Roberts; James Feeney; B Birdsall; P Charlton; D Young
Methotrexate binding to dihydrofolate reductase.
Nature 1980;286(5770):309.
1980: P Wyeth; A Gronenborn; Berry Birdsall; Gordon Roberts; James Feeney; A S Burgen
Histidine residues of Lactobacillus casei dihydrofolate reductase: paramagnetic relaxation and deuterium-exchange studies and partial assignments.
Biochemistry 1980;19(12):2608-15.
1980: James Feeney; Gordon Roberts; R Kaptein; Berry Birdsall; A Gronenborn; A S Burgen
Photo-CIDNP studies of the influence of ligand binding on the surface accessibility of aromatic residues in dihydrofolate reductase.
Biochemistry 1980;19(11):2466-72.
1980: James Feeney; Gordon Roberts; J W Thomson; R W King; D V Griffiths; A S Burgen
Proton nuclear magnetic resonance studies of the effects of ligand binding on tryptophan residues of selectively deuterated dihydrofolate reductase from Lactobacillus casei.
Biochemistry 1980;19(11):2316-21.
1980: J W Thomson; Gordon Roberts; A S Burgen
The effects of modification with N-bromosuccinimide on the binding of ligands to dihydrofolate reductase.
The Biochemical journal 1980;187(2):501-6.
1979: G Maghuin-Rogister; J Degelaen; Gordon Roberts
An approach of structure activity relationships of glycoprotein hormones by proton magnetic resonance (1H NMR) [proceedings].
Archives internationales de physiologie et de biochimie 1979;87(5):1029-30.
1979: P J Cayley; J P Albrand; James Feeney; Gordon Roberts; E A Piper; A S Burgen
Nuclear magnetic resonance studies of the binding of trimethoprim to dihydrofolate reductase.
Biochemistry 1979;18(18):3886-95.
1979: G Maghuin-Rogister; J Degelaen; Gordon Roberts
1H nuclear-magnetic-resonance studies of porcine lutropin and its alpha and beta subunits.
European journal of biochemistry / FEBS 1979;96(1):59-68.
1979: J Degelaen; James Feeney; Gordon Roberts; A S Burgen; J M Frère; J M Ghuysen
NMR evidence for the structure of the complex between penicillin and the DD-carboxypeptidase of Streptomyces R61.
FEBS letters 1979;98(1):53-6.
1979: K Hood; P M Bayley; Gordon Roberts
Circular-dichroism studies of ligand binding to dihydrofolate reductase from Lactobacillus casei MTX/R.
The Biochemical journal 1979;177(2):425-32.
1978: B Birdsall; A S Burgen; J Rodrigues de Miranda; Gordon Roberts
Cooperativity in ligand binding to dihydrofolate reductase.
Biochemistry 1978;17(11):2102-10.
1978: K Hood; Gordon Roberts
Ultraviolet difference-spectroscopic studies of substrate and inhibitor binding to Lactobacillus casei dihydrofolate reductase.
The Biochemical journal 1978;171(2):357-66.
1978: G Maghuin-Rogister; J Degelaen; Gordon Roberts
NMR studies of the histidine residues of the alpha-subunit of porcine lutropin.
FEBS letters 1978;87(2):247-50.
1978: B J Kimber; James Feeney; Gordon Roberts; B Birdsall; D V Griffiths; A S Burgen; B D Sykes
Proximity of two tryptophan residues in dihydrofolate reductase determined by 19f NMR.
Nature 1978;271(5641):184-5.
1977: B Birdsall; Gordon Roberts; James Feeney; A S Burgen
31P NMR studies of the binding of adenosine-2'-phosphate to Lactobacillus casei dihydrofolate reductase.
FEBS letters 1977;80(2):313-6.
1977: B J Kimber; D V Griffiths; B Birdsall; R W King; P Scudder; James Feeney; Gordon Roberts; A S Burgen
19 Fnuclear magnetic resonance studies of ligand binding to 3-fluorotyrosine-and 6-fluorotryptophan-containing dihydrofolate reductase from Lactobacillus casei.
Biochemistry 1977;16(15):3492-500.
1977: James Feeney; Gordon Roberts; B Birdsall; D V Griffiths; R W King; P Scudder; A Burgen
1H nuclear magnetic resonance studies of the tyrosine residues of selectively deuterated Lactobacillus casei dihydrofolate reductase.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1977;196(1124):267-90.
1977: B Birdsall; D V Griffiths; Gordon Roberts; James Feeney; A Burgen
1H nuclear magnetic resonance studies of Lactobacillus casei dihydrofolate reductase: effects of substrate and inhibitor binding on the histidine residues.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1977;196(1124):251-65.
1977: B Birdsall; A S Burgen; James Feeney; J F Rodriguez de Miranda; Gordon Roberts
Co-operativity in ligand binding to dihydrofolate reductase [proceedings].
British journal of pharmacology 1977;59(3):521P.
1977: B Birdsall; A S Burgen; James Feeney; Gordon Roberts
31P and 1H n.m.r. studies of coenzyme binding to dihydrofolate reductase [proceedings].
British journal of pharmacology 1977;59(3):520P.
1977: Gordon Roberts
Origins of specificity in the binding of small molecules to dihydrofolate reductase.
Ciba Foundation symposium 1977;(60):89-104.
1977: K Hood; Gordon Roberts
The charge state of substrates and inhibitors when bound to Lactobacillus casei dihydrofolate reductase [proceedings].
Biochemical Society transactions 1977;5(3):771-2.
1976: D V Griffiths; James Feeney; Gordon Roberts; A S Burgen
Preparation of selectively deuterated aromatic amino acids for use in 1H NMR studies of proteins.
Biochimica et biophysica acta 1976;446(2):479-85.
1976: J G Dann; G Ostler; R A Bjur; R W King; P Scudder; P C Turner; Gordon Roberts; A S Burgen
Large-scale purification and characterization of dihydrofolate reductase from a methotrexate-resistant strain of Lactobacillus casei.
The Biochemical journal 1976;157(3):559-71.
1976: A G Lee; N J Birdsall; J C Metcalfe; G B Warren; Gordon Roberts
A determination of the mobility gradient in lipid bilayers by 13C nuclear magnetic resonance.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1976;193(1112):253-74.
1975: James Feeney; B Birdsall; Gordon Roberts; A S Burgen
31P NMR studies of NADPH and NADP+ binding to L. casei dihydrofolate reductase.
Nature 1975;257(5527):564-6.
1975: J L Way; B Birdsall; James Feeney; Gordon Roberts; A S Burgen
A nuclear magnetic resonance study of nicotinamide adenine dinucleotide phosphate binding to Lactobacillus casei dihydrofolate reductase.
Biochemistry 1975;14(15):3470-5.
1975: A Dell; D H Williams; H R Morris; G A Smith; James Feeney; Gordon Roberts
Structure revision of the antibiotic echinomycin.
Journal of the American Chemical Society 1975;97(9):2497-502.
1975: A S Burgen; Gordon Roberts; James Feeney
Binding of flexible ligands to macromolecules.
Nature 1975;253(5494):753-5.
1975: Frederick Benz; Gordon Roberts
Nuclear magnetic resonance studies of the unfolding of pancreatic ribonuclease. II. Unfolding by urea and guanidine hydrochloride.
Journal of molecular biology 1975;91(3):367-87.
1975: Frederick Benz; Gordon Roberts
Nucler magnetic resonance studies of the unfolding of pancreatic ribonuclease.
Journal of molecular biology 1975;91(3):345-65.
1975: Gordon Roberts
The binding of substrates and inhibitors to dihydrofolate reductase.
Biochemical Society transactions 1975;3(5):630-1.
1974: Gordon Roberts; James Feeney; A S Burgen; V Yuferov; J G Dann; R Bjur
Nuclear magnetic resonance studies of the binding of substrate analogs and coenzyme to dihydrofolate reductase from Lactobacillus casei.
Biochemistry 1974;13(26):5351-7.
1974: P J Sadler; Frederick Benz; Gordon Roberts
The effect of chloroplatinite on the 1H NMR spectrum of ribonuclease. Solvent accessibility of methionine residues.
Biochimica et biophysica acta 1974;359(1):13-21.
1974: A F Bradbury; A S Burgen; James Feeney; Gordon Roberts; D G Smyth
Unequivocal assignments of NH proton magnetic resonance bands in oxytocin using 2H- and 15N-substituted molecules.
FEBS letters 1974;42(2):179-82.
1974: MF Perutz; A R Fersht; S R Simon; Gordon Roberts
Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin.
Biochemistry 1974;13(10):2174-86.
1974: A S Burgen; J Dann; James Feeney; Gordon Roberts; V Yuferov
Proceedings: NMR studies of the binding of substrate analogues to L. casei dihydrofolate reductase.
British journal of pharmacology 1974;51(1):126P-127P.
1973: Gordon Roberts; Frederick Benz
Proton Fourier transform NMR studies of the unfolding of ribonuclease.
Annals of the New York Academy of Sciences 1973;222():130-48.
1973: P Rodgers; Gordon Roberts
13c NMR studies of the conformation of N-acetyl-L-tryptophan in its complex with chymotrypsin.
FEBS letters 1973;36(3):330-3.
1973: R R Ison; P Partington; Gordon Roberts
The conformation of catecholamines and related compounds in solution.
Molecular pharmacology 1973;9(6):756-65.
1973: J V Kilmartin; J J Breen; Gordon Roberts; C Ho
Direct measurement of the pK values of an alkaline Bohr group in human hemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(4):1246-9.
1972: Frederick Benz; Gordon Roberts; James Feeney; R R Ison
Proton spin-lattice relaxation studies of the histidine residues of pancreatic ribonuclease.
Biochimica et biophysica acta 1972;278(2):233-8.
1972: Y K Levine; P Partington; Gordon Roberts; N J Birdsall; A G Lee; J C Metcalfe
13 C nuclear magnetic relaxation times and models for chain motion in lecithin vesicles.
FEBS letters 1972;23(2):203-7.
1972: R R Ison; P Partington; Gordon Roberts
The conformation of 5-hydroxytryptamine in solution.
The Journal of pharmacy and pharmacology 1972;24(1):82-5.
1971: James Feeney; Gordon Roberts; A S Burgen
Conformational studies of some hormonal peptides in solution by using nuclear-magnetic-resonance spectroscopy.
The Biochemical journal 1971;125(3):62P.
1971: Gordon Roberts; James Feeney
The combination of nuclear-magnetic-resonance spectroscopy and potential-energy calculations in the study of peptide conformation in solution.
The Biochemical journal 1971;125(4):88P-89P.
1971: James Feeney; Gordon Roberts; J H Rockey; A S Burgen
Conformational studies of oxytocin and lysine vasopressin in aqueous solution using high resolution NMR spectroscopy.
Nature: New biology 1971;232(30):108-10.