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Sandra Gemma

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Chemicals & Drugs

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TOP 3
Stefania Butini; Walter Cabri; Giuseppe Campiani; Diana Celona; Sabrina Dallavalle; Filomena Fezza; Sandra Gemma; Samuele Maramai; Lucio Merlini; Patrizia Minetti; Raffaella Napolitano; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.
Stefania Butini; Giuseppe Campiani; Alice Casagni; Emanuele Gabellieri; Mariateresa Giustiniano; Egeria Guarino; Paul B Huleatt; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Nicola Relitti; Margherita Brindisi; Sandra Gemma
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Sandra Gemma; Roberta Gualdani; Annette Habluetzel; Gagan Kukreja; Sanil Kunjir; Stefania Lamponi; Leonardo Lucantoni; Rowena E Martin; Maria Rosa Moncelli; Ettore Novellino; Luisa Savini; Robert L Summers; Francesco Tadini Buoninsegni; Donatella Taramelli; massimo valoti; Gianluca Bartolommei; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Caterina Camodeca; Giuseppe Campiani; Isabella Fiorini; Emanuele Gabellieri; Stefania Butini
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.

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All Publications

2013: Stefania Butini; Walter Cabri; Giuseppe Campiani; Diana Celona; Sabrina Dallavalle; Filomena Fezza; Sandra Gemma; Samuele Maramai; Lucio Merlini; Patrizia Minetti; Raffaella Napolitano; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.
Bioorganic & medicinal chemistry letters 2013;23(2):492-5.
2013: Stefania Butini; Giuseppe Campiani; Alice Casagni; Emanuele Gabellieri; Mariateresa Giustiniano; Egeria Guarino; Paul B Huleatt; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Nicola Relitti; Margherita Brindisi; Sandra Gemma
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Bioorganic & medicinal chemistry letters 2013;23(1):85-9.
2012: Sandra Gemma; Roberta Gualdani; Annette Habluetzel; Gagan Kukreja; Sanil Kunjir; Stefania Lamponi; Leonardo Lucantoni; Rowena E Martin; Maria Rosa Moncelli; Ettore Novellino; Luisa Savini; Robert L Summers; Francesco Tadini Buoninsegni; Donatella Taramelli; massimo valoti; Gianluca Bartolommei; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Caterina Camodeca; Giuseppe Campiani; Isabella Fiorini; Emanuele Gabellieri; Stefania Butini
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Journal of medicinal chemistry 2012;55(23):10387-404.
2012: Sandra Gemma; Simone Giovani; Ettore Novellino; Maria Penzo; Luisa Savini; Pierangela Tripaldi; Margherita Brindisi; Simone Brogi; Stefania Butini; Giuseppe Campiani; Isabella Fiorini; Michael J Blackman
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Bioorganic & medicinal chemistry letters 2012;22(16):5317-21.
2012: Stefania Butini; Sandra Gemma; Giuseppe Campiani
A straightforward approach for engineering efficacy and selectivity at GPCRs.
Journal of medicinal chemistry 2012;55(15):6687-8.
2012: Sandra Gemma; Beatrice Gorelli; Giovanna Guiso; Bhupendra P Joshi; Stefania Lamponi; Vittoria Moretti; Ettore Novellino; Silvia Parapini; Matthias Rottmann; Salvatore Sanna Coccone; simona saponara; Luisa Savini; Robert L Summers; Donatella Taramelli; Rowena E Martin; Nicoletta Basilico; Matteo Bernetti; Maria Cruz Bonache de Marcos; Simone Brogi; Reto Brun; S Caccia; Caterina Camodeca; Giuseppe Campiani; Stefania Butini
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
Journal of medicinal chemistry 2012;55(15):6948-67.
2012: Stefania Butini; Walter Cabri; Giuseppe Campiani; Antonio Caprioli; Stefano Di Serio; Filomena Fezza; Grazia Gallo; Sandra Gemma; Samuele Maramai; Patrizia Minetti; Sindu Ros; M Antonietta Stasi; Emanuela Talamonti; Silvia Vincenti; Giuseppe Borrelli; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.
Journal of medicinal chemistry 2012;55(15):6898-915.
2011: Gianluca Bartolommei; Stefania Butini; Caterina Camodeca; Giuseppe Campiani; Sandra Gemma; David Lewis; Maria Rosa Moncelli; Francesco Tadini Buoninsegni; Giuseppe Inesi
The Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functional.
The Journal of biological chemistry 2011;286(44):38383-9.
2011: Sandra Gemma; Sanil Kunjir; Vittoria Moretti; Ettore Novellino; Silvia Parapini; Donatella Taramelli; Salvatore Sanna Coccone; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Giuseppe Campiani; Stefania Butini
Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues.
Journal of medicinal chemistry 2011;54(16):5949-53.
2011: Sandra Gemma; Gianluca Giorgi; Bhupendra P Joshi; Ettore Novellino; Mario Salmona; Luisa Savini; Orazio Taglialatela-Scafati; Pierangela Tripaldi; Silvio Caccia; Giuseppe Campiani; Laura Colombo; Isabella Fiorini; Gianluigi Forloni; Claudia Fracasso; Margherita Brindisi; Stefania Butini
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.
Organic & biomolecular chemistry 2011;9(14):5137-48.
2011: Raminta Venskutonyte; Elena Antón Valadés; Salvatore Valenti; Ahmad Amir; Margherita Brindisi; Stefania Butini; Giuseppe Campiani; Salvatore Sanna Coccone; Karla Frydenvang; Sandra Gemma; Egeria Guarino; Jette S Kastrup; Vinod Kumar; Samuele Maramai; Ettore Novellino; Darryl S Pickering
Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.
Journal of medicinal chemistry 2011;54(13):4793-805.
2011: Stefania Butini; Giuseppe Campiani; Marcella Facchini; Isabella Fiorini; Federico Focher; Sandra Gemma; Aristotele Karytinos; Andrea Lossani; Giuseppe Borrelli; Margherita Brindisi; Ettore Novellino; Alberta Samuele; Samantha Zanoli; giovanni maga
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Bioorganic & medicinal chemistry letters 2011;21(13):3935-8.
2011: Sandra Gemma; Stefania Butini; Giuseppe Campiani; Margherita Brindisi; Samantha Zanoli; Maria Pia Romano; Pierangela Tripaldi; Luisa Savini; Isabella Fiorini; Giuseppe Borrelli; Ettore Novellino; giovanni maga
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
Bioorganic & medicinal chemistry letters 2011;21(9):2776-9.
2011: Stefania Butini; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Andrea Lossani; Anna Maria Ponte; Andrea Torti; giovanni maga; Luciana Marinelli; Valeria La Pietra; Isabella Fiorini; Stefania Lamponi; Giuseppe Campiani; Daniela M Zisterer; Seema-Maria Nathwani; Stefania Sartini; Concettina La Motta; Federico Da Settimo; Ettore Novellino; Federico Focher
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.
Journal of medicinal chemistry 2011;54(5):1401-20.
2010: Sandra Gemma; Valter Travagli; Luisa Savini; Ettore Novellino; Giuseppe Campiani; Stefania Butini
Malaria chemotherapy: recent advances in drug development.
Recent patents on anti-infective drug discovery 2010;5(3):195-225.
2010: Stefania Butini; Giuseppe Campiani; Silvia Franceschini; Francesco Trotta; Vinod Kumar; Egeria Guarino; Giuseppe Borrelli; Isabella Fiorini; Ettore Novellino; Caterina Fattorusso; Marco Persico; Nausicaa Orteca; Karin Sandager-Nielsen; Thomas Amos Jacobsen; Kim Madsen; Jorgen Scheel-Kruger; Sandra Gemma
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.
Journal of medicinal chemistry 2010;53(12):4803-7.
2010: Sandra Gemma; Emanuele Gabellieri; Salvatore Sanna Coccone; Francesc Martí; Orazio Taglialatela-Scafati; Ettore Novellino; Giuseppe Campiani; Stefania Butini
Synthesis of dihydroplakortin, 6-epi-dihydroplakortin, and their C10-desethyl analogues.
The Journal of organic chemistry 2010;75(7):2333-40.
2010: Arun K Ghosh; Sandra Gemma; Elena Simoni; Abigail Baldridge; Eric Walters; Kazuhiko Ide; Yasushi Tojo; yasuhiro koh; Masayuki Amano; Hiroaki Mitsuya
Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands.
Bioorganic & medicinal chemistry letters 2010;20(3):1241-6.
2010: Andrea Cappelli; Stefania Butini; Antonella Brizzi; Sandra Gemma; Salvatore Valenti; Germano Giuliani; Maurizio Anzini; Laura Mennuni; Giuseppe Campiani; Vittorio Brizzi; Salvatore Vomero
The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium.
Current topics in medicinal chemistry 2010;10(5):504-26.
2009: Stefania Butini; Roberta Budriesi; Michel Hamon; Elena Morelli; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Ettore Novellino; Isabella Fiorini; Pierfranco Ioan; Alberto Chiarini; Alfredo Cagnotto; Tiziana Mennini; Claudia Fracasso; S Caccia; Giuseppe Campiani
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
Journal of medicinal chemistry 2009;52(21):6946-50.
2009: Sandra Gemma; Luisa Savini; Maria Altarelli; Pierangela Tripaldi; Luisa Chiasserini; Salvatore Sanna Coccone; Vinod Kumar; Caterina Camodeca; Giuseppe Campiani; Ettore Novellino; Sandra Clarizio; Giovanni Delogu; Stefania Butini
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies.
Bioorganic & medicinal chemistry 2009;17(16):6063-72.
2009: Elena Morelli; Sandra Gemma; Roberta Budriesi; Giuseppe Campiani; Ettore Novellino; Caterina Fattorusso; Bruno Catalanotti; Salvatore Sanna Coccone; Sindu Ros; Giuseppe Borrelli; Marco Persico; Isabella Fiorini; Vito Nacci; Pierfranco Ioan; Alberto Chiarini; Michel Hamon; Alfredo Cagnotto; Tiziana Mennini; Claudia Fracasso; Milena Colovic; S Caccia; Stefania Butini
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Journal of medicinal chemistry 2009;52(11):3548-62.
2009: Stefania Butini; Margherita Brindisi; Sandro Cosconati; Luciana Marinelli; Giuseppe Borrelli; Salvatore Sanna Coccone; Anna Ramunno; Giuseppe Campiani; Ettore Novellino; Samantha Zanoli; Alberta Samuele; Gianluca Giorgi; Alberto Bergamini; Michela Di Mattia; Silvana Lalli; Bruno Galletti; Sandra Gemma; giovanni maga
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry 2009;52(4):1224-8.
2009: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Bhupendra P Joshi; Gagan Kukreja; Salvatore Sanna Coccone; Matteo Bernetti; Marco Persico; Vito Nacci; Isabella Fiorini; Ettore Novellino; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Vanessa Yardley; Simon Croft; Sonja Keller-Maerki; Matthias Rottmann; Reto Brun; Massimo Coletta; Stefano Marini; Giovanna Guiso; S Caccia; Caterina Fattorusso
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.
Journal of medicinal chemistry 2009;52(2):502-13.
2009: Stefania Butini; Sandra Gemma; Giuseppe Campiani; Silvia Franceschini; Francesco Trotta; Marianna Borriello; Nicoletta Ceres; Sindu Ros; Salvatore Sanna Coccone; Matteo Bernetti; Meri De Angelis; Margherita Brindisi; Vito Nacci; Isabella Fiorini; Ettore Novellino; Alfredo Cagnotto; Tiziana Mennini; Karin Sandager-Nielsen; Jesper Andreasen; Jorgen Scheel-Kruger; Jens D Mikkelsen; Caterina Fattorusso
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Journal of medicinal chemistry 2009;52(1):151-69.
2008: Stefania Butini; Emanuele Gabellieri; Paul Brady Huleatt; Giuseppe Campiani; Silvia Franceschini; Margherita Brindisi; Sindu Ros; Salvatore Sanna Coccone; Isabella Fiorini; Ettore Novellino; Gianluca Giorgi; Sandra Gemma
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.
The Journal of organic chemistry 2008;73(21):8458-68.
2008: Stefania Butini; Darryl S Pickering; Elena Morelli; Salvatore Sanna Coccone; Francesco Trotta; Meri De Angelis; Egeria Guarino; Isabella Fiorini; Giuseppe Campiani; Ettore Novellino; Arne Schousboe; Jeppe K Christensen; Sandra Gemma
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Journal of medicinal chemistry 2008;51(20):6614-8.
2008: Arun K Ghosh; Sandra Gemma; Jun Takayama; Abigail Baldridge; Sofiya Leshchenko-Yashchuk; Heather B Miller; Yuan-Fang Wang; Andrey Yu Kovalevsky; yasuhiro koh; Irene T Weber; Hiroaki Mitsuya
Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies.
Organic & biomolecular chemistry 2008;6(20):3703-13.
2008: Arun K Ghosh; Sandra Gemma; Abigail Baldridge; Yuan-Fang Wang; Andrey Yu Kovalevsky; yasuhiro koh; Irene T Weber; Hiroaki Mitsuya
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies.
Journal of medicinal chemistry 2008;51(19):6021-33.
2008: Stefania Butini; Egeria Guarino; Giuseppe Campiani; Margherita Brindisi; Salvatore Sanna Coccone; Isabella Fiorini; Ettore Novellino; Tatyana Belinskaya; Ashima Saxena; Sandra Gemma
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.
Bioorganic & medicinal chemistry letters 2008;18(19):5213-6.
2008: Samantha Zanoli; Sandra Gemma; Stefania Butini; Margherita Brindisi; Bhupendra P Joshi; Giuseppe Campiani; Caterina Fattorusso; Marco Persico; Emmanuele Crespan; Reynel Cancio; Silvio Spadari; Ulrich Hübscher; giovanni maga
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.
Biochemical pharmacology 2008;76(2):156-68.
2008: Arun K Ghosh; Sandra Gemma; Jordan Tang
beta-Secretase as a therapeutic target for Alzheimer's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):399-408.
2008: Stefania Butini; Giuseppe Campiani; Marianna Borriello; Sandra Gemma; Alessandro Panico; Marco Persico; Bruno Catalanotti; Sindu Ros; Margherita Brindisi; Marianna Agnusdei; Isabella Fiorini; Vito Nacci; Ettore Novellino; Tatyana Belinskaya; Ashima Saxena; Caterina Fattorusso
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry 2008;51(11):3154-70.
2008: N Basilico; E Bosisio; F Buelli; G Campiani; M Casagrande; F Castelli; P Coghi; Y Corbett; L Cortelezzi; S D'Alessandro; M Dell'Agli; F Esposito; C Fattorusso; E Fattorusso; S Finaurini; G V Galli; Sandra Gemma; A Habluetzel; Leonardo Lucantoni; S Melato; D Monti; P Olliaro; F Omodeo-Salè; S Parapini; M Persico; M Rizzi; S Romeo; F Rossi; C Rusconi; A Sparatore; O Taglialatela Scafati; E van den Bogaart; D Taramelli; N Vaiana; S Yerbanga
Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network.
Parassitologia 2008;50(1-2):133-6.
2008: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Gagan Kukreja; Salvatore Sanna Coccone; Bhupendra P Joshi; Marco Persico; Vito Nacci; Isabella Fiorini; Ettore Novellino; Ernesto Fattorusso; Orazio Taglialatela-Scafati; Luisa Savini; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Giulia Morace; Vanessa Yardley; Simon L Croft; Massimiliano Coletta; Stefano Marini; Caterina Fattorusso
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.
Journal of medicinal chemistry 2008;51(5):1278-94.
2008: Caterina Fattorusso; Giuseppe Campiani; Gagan Kukreja; Marco Persico; Stefania Butini; Maria Pia Romano; Maria Altarelli; Sindu Ros; Margherita Brindisi; Luisa Savini; Ettore Novellino; Vito Nacci; Ernesto Fattorusso; Silvia Parapini; Nicoletta Basilico; Donatella Taramelli; Vanessa Yardley; Simon L Croft; Marianna Borriello; Sandra Gemma
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.
Journal of medicinal chemistry 2008;51(5):1333-43.
2007: Sandra Gemma; Gagan Kukreja; Giuseppe Campiani; Stefania Butini; Matteo Bernetti; Bhupendra P Joshi; Luisa Savini; Nicoletta Basilico; Donatella Taramelli; Vanessa Yardley; Alessia Bertamino; Ettore Novellino; Marco Persico; Bruno Catalanotti; Caterina Fattorusso
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling.
Bioorganic & medicinal chemistry letters 2007;17(13):3535-9.
2007: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Gagan Kukreja; Bhupendra P Joshi; Marco Persico; Bruno Catalanotti; Ettore Novellino; Ernesto Fattorusso; Vito Nacci; Luisa Savini; Donatella Taramelli; Nicoletta Basilico; Giulia Morace; Vanessa Yardley; Caterina Fattorusso
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.
Journal of medicinal chemistry 2007;50(4):595-8.
2006: Sandra Gemma; Gagan Kukreja; Caterina Fattorusso; Marco Persico; Maria P Romano; Maria Altarelli; Luisa Savini; Giuseppe Campiani; Ernesto Fattorusso; Nicoletta Basilico; Donatella Taramelli; Vanessa Yardley; Stefania Butini
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Bioorganic & medicinal chemistry letters 2006;16(20):5384-8.
2006: Sandra Gemma; Emanuele Gabellieri; Paul Huleatt; Caterina Fattorusso; Marianna Borriello; Bruno Catalanotti; Stefania Butini; Meri De Angelis; Ettore Novellino; Vito Nacci; Tatyana Belinskaya; Ashima Saxena; Giuseppe Campiani
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Journal of medicinal chemistry 2006;49(11):3421-5.
2005: Caterina Fattorusso; Sandra Gemma; Stefania Butini; Paul Huleatt; Bruno Catalanotti; Marco Persico; Meri De Angelis; Isabella Fiorini; Vito Nacci; Anna Ramunno; Manuela Rodriquez; Giovanni Greco; Ettore Novellino; Alberto Bergamini; Stefano Marini; Massimo Coletta; giovanni maga; Silvio Spadari; Giuseppe Campiani
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Journal of medicinal chemistry 2005;48(23):7153-65.
2005: giovanni maga; Sandra Gemma; Caterina Fattorusso; Giada A Locatelli; Stefania Butini; Marco Persico; Gagan Kukreja; Maria Pia Romano; Luisa Chiasserini; Luisa Savini; Ettore Novellino; Vito Nacci; Silvio Spadari; Giuseppe Campiani
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.
Biochemistry 2005;44(28):9637-44.
2005: Margaret M Mc Gee; Sandra Gemma; Stefania Butini; Anna Ramunno; Daniela M Zisterer; Caterina Fattorusso; Bruno Catalanotti; Gagan Kukreja; Isabella Fiorini; Claudio Pisano; Carla Cucco; Ettore Novellino; Vito Nacci; D Clive Williams; Giuseppe Campiani
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target.
Journal of medicinal chemistry 2005;48(13):4367-77.
2005: Giuseppe Campiani; Caterina Fattorusso; Stefania Butini; Alessandra Gaeta; Marianna Agnusdei; Sandra Gemma; Marco Persico; Bruno Catalanotti; Luisa Savini; Vito Nacci; Ettore Novellino; Harold W Holloway; Nigel H Greig; Tatyana Belinskaya; James M Fedorko; Ashima Saxena
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry 2005;48(6):1919-29.
2005: Giuseppe Campiani; Stefania Butini; Caterina Fattorusso; Francesco Trotta; Sandra Gemma; Bruno Catalanotti; Vito Nacci; Isabella Fiorini; Alfredo Cagnotto; Ilario Mereghetti; Tiziana Mennini; Patrizia Minetti; M Assunta Di Cesare; M Antonietta Stasi; Stefano Di Serio; Orlando Ghirardi; Ornella Tinti; Paolo Carminati
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.
Journal of medicinal chemistry 2005;48(6):1705-8.
2004: Giada A Locatelli; Giuseppe Campiani; Reynel Cancio; Elena Morelli; Anna Ramunno; Sandra Gemma; Ulrich Hübscher; Silvio Spadari; giovanni maga
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex.
Antimicrobial agents and chemotherapy 2004;48(5):1570-80.
2004: Giuseppe Campiani; Stefania Butini; Caterina Fattorusso; Bruno Catalanotti; Sandra Gemma; Vito Nacci; Elena Morelli; Alfredo Cagnotto; Ilario Mereghetti; Tiziana Mennini; Miriana Carli; Patrizia Minetti; M Assunta Di Cesare; Domenico mastroianni; Nazzareno Scafetta; Bruno Galletti; M Antonietta Stasi; Massimo Castorina; Licia Pacifici; Mario Vertechy; Stefano Di Serio; Orlando Ghirardi; Ornella Tinti; Paolo Carminati
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.
Journal of medicinal chemistry 2004;47(1):143-57.
2003: Giuseppe Campiani; Stefania Butini; Francesco Trotta; Caterina Fattorusso; Bruno Catalanotti; Francesca Aiello; Sandra Gemma; Vito Nacci; Ettore Novellino; Jennifer Ann Stark; Alfredo Cagnotto; Elena Fumagalli; Francesco Carnovali; Luigi Cervo; Tiziana Mennini
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
Journal of medicinal chemistry 2003;46(18):3822-39.
2002: Giuseppe Campiani; Stefania Butini; Sandra Gemma; Vito Nacci; Caterina Fattorusso; Bruno Catalanotti; Gianluca Giorgi; Alfredo Cagnotto; Mara Goegan; Tiziana Mennini; Patrizia Minetti; M Assunta Di Cesare; Domenico mastroianni; Nazzareno Scafetta; Bruno Galletti; M Antonietta Stasi; Massimo Castorina; Licia Pacifici; Orlando Ghirardi; Ornella Tinti; Paolo Carminati
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Journal of medicinal chemistry 2002;45(2):344-59.
1999: Giuseppe Campiani; Elena Morelli; Sandra Gemma; Vito Nacci; Stefania Butini; Michel Hamon; Ettore Novellino; Giovanni Greco; Alfredo Cagnotto; Mara Goegan; Luigi Cervo; F Dalla Valle; Claudia Fracasso; S Caccia; Tiziana Mennini
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Journal of medicinal chemistry 1999;42(21):4362-79.