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Bertil B. Fredholm

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Jiang-Fan Chen; Holger K Eltzschig; Bertil B. Fredholm
Adenosine receptors as drug targets--what are the challenges?
Bertil B. Fredholm
[The Nobel Prize to detailed studies of G protein-coupled receptors. This years Nobel Prize in chemistry provides important knowledge--but it might take a while before it can be practically applied].
Robert A Figler; Guoquan Wang; Susseela Srinivasan; Dae Young Jung; Zhiyou Zhang; James S Pankow; Katya Ravid; Bertil B. Fredholm; Catherine C Hedrick; Stephen S Rich; Jason K Kim; Kathryn F LaNoue; Joel Linden
Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans.

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All Publications

2013: Jiang-Fan Chen; Holger K Eltzschig; Bertil B. Fredholm
Adenosine receptors as drug targets--what are the challenges?
Nature reviews. Drug discovery 2013;12(4):265-86.
2012: Bertil B. Fredholm
[The Nobel Prize to detailed studies of G protein-coupled receptors. This years Nobel Prize in chemistry provides important knowledge--but it might take a while before it can be practically applied].
Läkartidningen 2012;109(49-50):2274-5.
2011: Robert A Figler; Guoquan Wang; Susseela Srinivasan; Dae Young Jung; Zhiyou Zhang; James S Pankow; Katya Ravid; Bertil B. Fredholm; Catherine C Hedrick; Stephen S Rich; Jason K Kim; Kathryn F LaNoue; Joel Linden
Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans.
Diabetes 2011;60(2):669-79.
2011: Bertil B. Fredholm
Preface. Methylxanthines.
Handbook of experimental pharmacology 2011;(200):vii-viii.
2010: Terry Kenakin; Luigi F Agnati; Marc Caron; Bertil B. Fredholm; Diego Guidoli; Brian Kobilka; Robert W Lefkowitz; Martin Lohse; Amina S Woods; Kjell Fuxe
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?
Journal of receptor and signal transduction research 2010;30(5):284-6.
2010: S Piccinin; Silvia Di Angelantonio; A Piccioni; R Volpini; G Cristalli; Bertil B. Fredholm; Cristina Limatola; Fabrizio Eusebi; Davide Ragozzino
CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes.
Journal of neuroimmunology 2010;224(1-2):85-92.
2010: Detlev Boison; J-F Chen; Bertil B. Fredholm
Adenosine signaling and function in glial cells.
Cell death and differentiation 2010;17(7):1071-82.
2010: Bertil B. Fredholm; A Verkhratsky
Purines - 80 years and very much alive.
Acta physiologica (Oxford, England) 2010;199(2):91-2.
2010: Geoffrey Burnstock; Bertil B. Fredholm; R A North; A Verkhratsky
The birth and postnatal development of purinergic signalling.
Acta physiologica (Oxford, England) 2010;199(2):93-147.
2010: Clotilde Lauro; Raffaela Cipriani; Myriam Catalano; Flavia Trettel; Giuseppina Chece; Valentina Brusadin; Letizia Antonilli; Nico van Rooijen; Fabrizio Eusebi; Bertil B. Fredholm; Cristina Limatola
Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(7):1550-9.
2010: Y Wang; J N Yang; Anders Arner; P J M Boels; Bertil B. Fredholm
Adenosine A(1) receptors and vascular reactivity.
Acta physiologica (Oxford, England) 2010;199(2):211-20.
2010: J N Yang; Y Wang; Pablo M Garcia-Roves; Marie Björnholm; Bertil B. Fredholm
Adenosine A(3) receptors regulate heart rate, motor activity and body temperature.
Acta physiologica (Oxford, England) 2010;199(2):221-30.
2010: Bertil B. Fredholm
Adenosine receptors as drug targets.
Experimental cell research 2010;316(8):1284-8.
2010: Jana Sawynok; Allison R Reid; Bertil B. Fredholm
Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice.
Neuroscience letters 2010;473(3):178-81.
2010: Firas M Kara; Stephen B Doty; Adele Boskey; Steven Goldring; Mone Zaidi; Bertil B. Fredholm; Bruce N Cronstein
Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice.
Arthritis and rheumatism 2010;62(2):534-41.
2009: Laura Maggi; Flavia Trettel; Maria Scianni; Cristina Bertollini; Fabrizio Eusebi; Bertil B. Fredholm; Cristina Limatola
LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R).
Journal of neuroimmunology 2009;215(1-2):36-42.
2009: Albert Salehi; Fariborz Parandeh; Bertil B. Fredholm; Eva Grapengiesser; Bo Hellman
Absence of adenosine A1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin.
Life sciences 2009;85(11-12):470-6.
2009: Peter Jenner; A Mori; Robert A Hauser; M Morelli; Bertil B. Fredholm; J F Chen
Adenosine, adenosine A 2A antagonists, and Parkinson's disease.
Parkinsonism & related disorders 2009;15(6):406-13.
2009: Liqun Yu; Joana E Coelho; Xiaoling Zhang; Yutao Fu; Abigail Tillman; Ulas Karaoz; Bertil B. Fredholm; Zhiping Weng; Jiang-Fan Chen
Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling.
Physiological genomics 2009;37(3):199-210.
2009: Jiang-Ning Yang; Jiang-Fan Chen; Bertil B. Fredholm
Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.
American journal of physiology. Heart and circulatory physiology 2009;296(4):H1141-9.
2009: Carmela Conte; Silvia Grottelli; Elvira Prudenzi; Ilaria Bellezza; Bertil B. Fredholm; Alba Minelli
A(1) and A(3) adenosine receptors alter glutathione status in an organ-specific manner and influence the changes after inhibition of gamma-glutamylcysteine ligase.
Free radical research 2009;43(3):304-11.
2009: Jiang-Ning Yang; Olga Björklund; Karin Lindström-Törnqvist; Eva Lindgren; Therese M Eriksson; Johan Kahlström; Jiang-Fan Chen; Michael A Schwarzschild; Irene Tobler; Bertil B. Fredholm
Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(2):631-9.
2008: Yo Oishi; Zhi-Li Huang; Bertil B. Fredholm; Yoshihiro Urade; Osamu Hayaishi
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(50):19992-7.
2008: Olga Björklund; Linda Halldner-Henriksson; Jiangning Yang; Therese M Eriksson; Marlene A Jacobson; Elisabetta Daré; Bertil B. Fredholm
Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.
Physiology & behavior 2008;95(5):668-76.
2008: Stina M Johansson; Eva Lindgren; Jiang-Ning Yang; Andreas W Herling; Bertil B. Fredholm
Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue-interactions with insulin.
European journal of pharmacology 2008;597(1-3):92-101.
2008: Olga Björklund; Mingmei Shang; Ilaria Tonazzini; Elisabetta Daré; Bertil B. Fredholm
Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage.
European journal of pharmacology 2008;596(1-3):6-13.
2008: Cristina Roseti; Katiuscia Martinello; Sergio Fucile; Vanessa Piccari; Addolorata Mascia; Giancarlo Di Gennaro; Pier Paolo Quarato; Mario Manfredi; Vincenzo Esposito; Giampaolo Cantore; Antonietta Arcella; Michele Simonato; Bertil B. Fredholm; Cristina Limatola; Ricardo Miledi; Fabrizio Eusebi
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):15118-23.
2008: Frank Brand; Athena M Klutz; Kenneth Alan Jacobson; Bertil B. Fredholm; Gunnar Schulte
Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.
European journal of pharmacology 2008;590(1-3):36-42.
2008: Jana Sawynok; Allison R Reid; Bertil B. Fredholm
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
Neuroscience letters 2008;440(2):181-4.
2008: Xiaoyang Hua; Kelly D Chason; Bertil B. Fredholm; Deepak A Deshpande; Raymond B Penn; Stephen L Tilley
Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells.
The Journal of allergy and clinical immunology 2008;122(1):107-13, 113.e1-7.
2008: sheng xia; Xing-Peng Dun; Ping-Sheng Hu; Svend Kjaer; Kang Zheng; Yu Qian; Christina Solén; Tao Xu; Bertil B. Fredholm; Tomas Hökfelt; Zhi-Qing David Xu
Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5609-13.
2008: Liying Chen; Bertil B. Fredholm; Mikael Jondal
Adenosine, through the A1 receptor, inhibits vesicular MHC class I cross-presentation by resting DC.
Molecular immunology 2008;45(8):2247-54.
2008: Alba Minelli; Ilaria Bellezza; Giulia Collodel; Bertil B. Fredholm
Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1/2 in the adenosine A1 receptor signalling in mammalian spermatozoa.
Biochemical pharmacology 2008;75(4):931-41.
2008: Olga Björklund; Johan Kahlström; Peter Salmi; Bertil B. Fredholm
Perinatal caffeine, acting on maternal adenosine A(1) receptors, causes long-lasting behavioral changes in mouse offspring.
PloS one 2008;3(12):e3977.
2007: Stina M Johansson; Albert Salehi; Marie E Sandström; Håkan Westerblad; Ingmar Lundquist; Per-Ola Carlsson; Bertil B. Fredholm; Abram Katz
A1 receptor deficiency causes increased insulin and glucagon secretion in mice.
Biochemical pharmacology 2007;74(11):1628-35.
2007: Akio Ohta; Dmitriy Lukashev; Edwin K Jackson; Bertil B. Fredholm; Michail V Sitkovsky
1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7431-8.
2007: Bertil B. Fredholm; Yijuang Chern; Rafael Franco; Michail V Sitkovsky
Aspects of the general biology of adenosine A2A signaling.
Progress in neurobiology 2007;83(5):263-76.
2007: Olga Björklund; Johan Kahlström; Peter Salmi; Sven Ove Ogren; Marie Vahter; Jiang-Fan Chen; Bertil B. Fredholm; Elisabetta Daré
The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration.
Toxicology 2007;241(3):119-33.
2007: Tianfu Li; Jing Quan Lan; Bertil B. Fredholm; Roger P. Simon; Detlev Boison
Adenosine dysfunction in astrogliosis: cause for seizure generation?
Neuron glia biology 2007;3(4):353-66.
2007: Elisabetta Daré; Gunnar Schulte; Olga Karovic; Christian Hammarberg; Bertil B. Fredholm
Modulation of glial cell functions by adenosine receptors.
Physiology & behavior 2007;92(1-2):15-20.
2007: Jan Sällström; Per-Ola Carlsson; Bertil B. Fredholm; Erik Larsson; A Erik G Persson; Fredrik Palm
Diabetes-induced hyperfiltration in adenosine A(1)-receptor deficient mice lacking the tubuloglomerular feedback mechanism.
Acta physiologica (Oxford, England) 2007;190(3):253-9.
2007: Bertil B. Fredholm
Adenosine, an endogenous distress signal, modulates tissue damage and repair.
Cell death and differentiation 2007;14(7):1315-23.
2007: Christopher C Wendler; Salina Amatya; Carolyn McClaskey; Satish Ghatpande; Bertil B. Fredholm; Scott A Rivkees
A1 adenosine receptors play an essential role in protecting the embryo against hypoxia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9697-702.
2007: Toshihide Tabata; Daisuke Kawakami; Kouichi Hashimoto; Hidetoshi Kassai; Takayuki Yoshida; Yuki Hashimotodani; Bertil B. Fredholm; Yuko Sekino; Atsu Aiba; Masanobu Kano
G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells.
The Journal of physiology 2007;581(Pt 2):693-708.
2007: S M Johansson; J-N Yang; E Lindgren; Bertil B. Fredholm
Eliminating the antilipolytic adenosine A1 receptor does not lead to compensatory changes in the antilipolytic actions of PGE2 and nicotinic acid.
Acta physiologica (Oxford, England) 2007;190(1):87-96.
2007: J-N Yang; C Tiselius; Elisabetta Daré; Björn Johansson; Guro Valen; Bertil B. Fredholm
Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors.
Acta physiologica (Oxford, England) 2007;190(1):63-75.
2007: Bertil B. Fredholm; T Hökfelt; G Milligan
G-protein-coupled receptors: an update.
Acta physiologica (Oxford, England) 2007;190(1):3-7.
2007: Gunnar Schulte; Bertil B. Fredholm
A Nordic meeting on G-protein-coupled receptors: from molecular aspects to novel therapy.
Acta physiologica (Oxford, England) 2007;190(1):1.
2007: Olga Karovic; Ilaria Tonazzini; Nelson Rebola; Erik Edström; Cecilia Lövdahl; Bertil B. Fredholm; Elisabetta Daré
Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha.
Biochemical pharmacology 2007;73(5):694-708.
2006: En Yin Lai; Andreas Patzak; Andreas Steege; Ralf Mrowka; Russell Brown; N Spielmann; Pontus B Persson; Bertil B. Fredholm; A Erik G Persson
Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction.
Kidney international 2006;70(4):690-8.
2006: Sietske M Schotanus; Bertil B. Fredholm; Karima Chergui
NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice.
Neuropharmacology 2006;51(2):272-82.
2006: Wei-Ping Wu; Jing-Xia Hao; Bertil B. Fredholm; Zsuzsanna Wiesenfeld-Hallin; Xiao-Jun Xu
Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury.
Neuroscience letters 2006;402(1-2):164-6.
2006: Denise E Fedele; Tianfu Li; Jing-Quan Lan; Bertil B. Fredholm; Detlev Boison
Adenosine A1 receptors are crucial in keeping an epileptic focus localized.
Experimental neurology 2006;200(1):184-90.
2006: Russell D Brown; Peter Thorén; Andreas Steege; Ralf Mrowka; Jan Sällström; Ole Skøtt; Bertil B. Fredholm; A Erik G Persson
Influence of the adenosine A1 receptor on blood pressure regulation and renin release.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(5):R1324-9.
2006: Malin Jonsson; Michael Dabrowski; David A Gurley; Olof Larsson; Edwin Johnson; Bertil B. Fredholm; Lars I Eriksson
Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine.
Anesthesiology 2006;104(4):724-33.
2006: Amy R Lankford; Jiang-Ning Yang; Roselyn Rose'Meyer; Brent A French; G Paul Matherne; Bertil B. Fredholm; Zequan Yang
Effect of modulating cardiac A1 adenosine receptor expression on protection with ischemic preconditioning.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1469-73.
2006: Alexander Kuzmin; Björn Johansson; Lydia Gimenez; Sven Ove Ogren; Bertil B. Fredholm
Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2006;16(2):129-36.
2005: R Nergårdh; S Oerther; Bertil B. Fredholm
Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors.
Pharmacology, biochemistry, and behavior 2005;82(3):495-505.
2005: Mina Kim; Zhao-Xue Yu; Bertil B. Fredholm; Scott A Rivkees
Susceptibility of the developing brain to acute hypoglycemia involving A1 adenosine receptor activation.
American journal of physiology. Endocrinology and metabolism 2005;289(4):E562-9.
2005: Mikael Andersson; Alessandro Usiello; Anders Borgkvist; Laura Pozzi; Cecilia Dominguez; Allen Fienberg; Per Svenningsson; Bertil B. Fredholm; Emiliana Borrelli; Paul Greengard; Gilberto Fisone
Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(37):8432-8.
2005: Stina Johansson; Bertil B. Fredholm; Charlotta Hjort; Torbjörn Morein; Björn Kull; Ping-Sheng Hu
Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor.
Biochemical pharmacology 2005;70(4):598-605.
2005: Zhi-Li Huang; Wei-Min Qu; Naomi Eguchi; Jiang-Fan Chen; Michael A Schwarzschild; Bertil B. Fredholm; Yoshihiro Urade; Osamu Hayaishi
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.
Nature neuroscience 2005;8(7):858-9.
2005: Lydia Giménez-Llort; Susan A Masino; Lihong Diao; Alberto Fernández-Teruel; Adolf Tobeña; Linda Halldner; Bertil B. Fredholm
Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly.
Synapse (New York, N.Y.) 2005;57(1):8-16.
2005: Ahmed Ammar; R Nergårdh; Bertil B. Fredholm; Ulf Brodin; Per Södersten
Intake inhibition by NPY and CCK-8: A challenge of the notion of NPY as an "Orexigen".
Behavioural brain research 2005;161(1):82-7.
2005: Esam Ghanem; Cecilia Lövdahl; Elisabetta Daré; Catherine Ledent; Bertil B. Fredholm; Jean-Marie Boeynaems; Willy Van Driessche; Renaud Beauwens
Luminal adenosine stimulates chloride secretion through A1 receptor in mouse jejunum.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(5):G972-7.
2005: Maria Kukley; Maximilian Schwan; Bertil B. Fredholm; Dirk Dietrich
The role of extracellular adenosine in regulating mossy fiber synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(11):2832-7.
2005: Wei-Ping Wu; Jing-Xia Hao; Linda Halldner; Cecilia Lövdahl; Gary E DeLander; Zsuzsanna Wiesenfeld-Hallin; Bertil B. Fredholm; Xiao-Jun Xu
Increased nociceptive response in mice lacking the adenosine A1 receptor.
Pain 2005;113(3):395-404.
2005: Peter Salmi; Karima Chergui; Bertil B. Fredholm
Adenosine-dopamine interactions revealed in knockout mice.
Journal of molecular neuroscience : MN 2005;26(2-3):239-44.
2005: Bertil B. Fredholm; Jiang-Fan Chen; Susan A Masino; Jean-Marie Vaugeois
Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.
Annual review of pharmacology and toxicology 2005;45():385-412.
2005: Bertil B. Fredholm; Jiang-Fan Chen; Rodrigo A Cunha; Per Svenningsson; Jean-Marie Vaugeois
Adenosine and brain function.
International review of neurobiology 2005;63():191-270.
2004: Gunnar Schulte; H Sommerschild; J Yang; Shinichi Tokuno; Michel Goiny; Cecilia Lövdahl; Björn Johansson; Bertil B. Fredholm; Guro Valen
Adenosine A receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia.
Acta physiologica Scandinavica 2004;182(2):133-43.
2004: Linda Halldner; luisa lopes; Elisabetta Daré; Karin Lindström; Björn Johansson; Catherine Ledent; Rodrigo A Cunha; Bertil B. Fredholm
Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(4):270-8.
2004: Tomas Olsson; Tobias Cronberg; Anna Rytter; Fredrik Asztély; Bertil B. Fredholm; Maj-Lis Smith; Tadeusz Wieloch
Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro.
The European journal of neuroscience 2004;20(5):1197-204.
2004: Malin Jonsson; Nicholas Wyon; Sten G E Lindahl; Bertil B. Fredholm; Lars I Eriksson
Neuromuscular blocking agents block carotid body neuronal nicotinic acetylcholine receptors.
European journal of pharmacology 2004;497(2):173-80.
2004: Bertil B. Fredholm
[Connection between caffeine, adenosine receptors and dopamine. Coffee reduces the risk of Parkinson disease].
Läkartidningen 2004;101(34):2552-5.
2004: Linda Halldner; Ulrika Adén; Viktoria Dahlberg; Björn Johansson; Catherine Ledent; Bertil B. Fredholm
The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors.
Neuropharmacology 2004;46(7):1008-17.
2004: Bertil B. Fredholm
Börje Uvnäs and the rise of modern pharmacology.
Trends in pharmacological sciences 2004;25(4):170-1.
2004: luisa lopes; Linda Halldner; Nelson Rebola; Björn Johansson; Catherine Ledent; Jian Fan Chen; Bertil B. Fredholm; Rodrigo A Cunha
Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.
British journal of pharmacology 2004;141(6):1006-14.
2004: Alba Minelli; Lavinia Liguori; Ilaria Bellazza; Roberta Mannucci; Björn Johansson; Bertil B. Fredholm
Involvement of A1 adenosine receptors in the acquisition of fertilizing capacity.
Journal of andrology 2004;25(2):286-92.
2004: Christian Hammarberg; Bertil B. Fredholm; Gunnar Schulte
Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase.
Biochemical pharmacology 2004;67(1):129-34.
2003: Per Svenningsson; Bertil B. Fredholm
Exciting news about A2A receptors.
Neurology 2003;61(11 Suppl 6):S10-1.
2003: Bertil B. Fredholm; Per Svenningsson
Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities.
Neurology 2003;61(11 Suppl 6):S5-9.
2003: Dag Stenberg; Erik Litonius; Linda Halldner; Björn Johansson; Bertil B. Fredholm; Tarja Porkka-Heiskanen
Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor.
Journal of sleep research 2003;12(4):283-90.
2003: Gunnar Schulte; Bertil B. Fredholm
The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38.
Experimental cell research 2003;290(1):168-76.
2003: Christopher P Turner; Meltem Seli; Laura R Ment; William Stewart; Henglin Yan; Bjorn Johansson; Bertil B. Fredholm; Michael Blackburn; Scott A Rivkees
A1 adenosine receptors mediate hypoxia-induced ventriculomegaly.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11718-22.
2003: Gunnar Schulte; Bertil B. Fredholm
Signalling from adenosine receptors to mitogen-activated protein kinases.
Cellular signalling 2003;15(9):813-27.
2003: Christian Hammarberg; Gunnar Schulte; Bertil B. Fredholm
Evidence for functional adenosine A3 receptors in microglia cells.
Journal of neurochemistry 2003;86(4):1051-4.
2003: Jan Lynge; Gunnar Schulte; Nikolai Nordsborg; Bertil B. Fredholm; Ylva Hellsten
Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells.
Biochemical and biophysical research communications 2003;307(1):180-7.
2003: Bertil B. Fredholm
Adenosine receptors as targets for drug development.
Drug news & perspectives 2003;16(5):283-9.
2003: Bertil B. Fredholm; Jean W Assender; Eva Irenius; Noriko Kodama; Naoaki Saito
Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells.
Cellular and molecular neurobiology 2003;23(3):379-400.
2003: Ulrika Adén; Linda Halldner; Hugo Lagercrantz; Ishar Dalmau; Catherine Ledent; Bertil B. Fredholm
Aggravated brain damage after hypoxic ischemia in immature adenosine A2A knockout mice.
Stroke; a journal of cerebral circulation 2003;34(3):739-44.
2003: Gunnar Schulte; B Robertson; Bertil B. Fredholm; G E DeLander; PJ Shortland; C Molander
Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations.
Neuroscience 2003;121(4):907-16.
2003: Bertil B. Fredholm; Rodrigo A Cunha; Per Svenningsson
Pharmacology of adenosine A2A receptors and therapeutic applications.
Current topics in medicinal chemistry 2003;3(4):413-26.
2002: Gunnar Schulte; Bertil B. Fredholm
Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2.
Molecular pharmacology 2002;62(5):1137-46.
2002: Susan A Masino; Lihong Diao; Peter Illes; Nancy R Zahniser; Gaynor A Larson; Björn Johansson; Bertil B. Fredholm; Thomas V Dunwiddie
Modulation of hippocampal glutamatergic transmission by ATP is dependent on adenosine a(1) receptors.
The Journal of pharmacology and experimental therapeutics 2002;303(1):356-63.
2002: Maria Lindskog; Per Svenningsson; Laura Pozzi; Yong Kim; Allen Fienberg; James A Bibb; Bertil B. Fredholm; Angus Nairn; Paul Greengard; Gilberto Fisone
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine.
Nature 2002;418(6899):774-8.
2002: Lydia Giménez-Llort; Alberto Fernández-Teruel; Rosa M Escorihuela; Bertil B. Fredholm; Adolf Tobeña; Milos Pekny; Björn Johansson
Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate.
The European journal of neuroscience 2002;16(3):547-50.
2002: Ulrika Adén; Viktoria Dahlberg; Bertil B. Fredholm; Li-Ju Lai; Zhengguan Chen; Börje Bjelke
MRI evaluation and functional assessment of brain injury after hypoxic ischemia in neonatal mice.
Stroke; a journal of cerebral circulation 2002;33(5):1405-10.
2002: Bertil B. Fredholm
[The passion concerning behavior of human beings. The intensive sociology debate and some lessons learned from it].
Läkartidningen 2002;99(14):1604-8.
2002: Bertil B. Fredholm; William W Fleming; Paul M Vanhoutte; Théophile Godfraind
The role of pharmacology in drug discovery.
Nature reviews. Drug discovery 2002;1(3):237-8.
2002: Giulia Arslan; Björn Kull; Bertil B. Fredholm
Anoxia redistributes adenosine A(2A) receptors in PC12 cells and increases receptor-mediated formation of cAMP.
Naunyn-Schmiedeberg's archives of pharmacology 2002;365(2):150-7.
2002: Gunnar Schulte; Bertil B. Fredholm
Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists.
Cellular signalling 2002;14(2):109-13.
2002: Wei-Ping Wu; Jing-Xia Hao; L Halldner-Henriksson; Xiao-Jun Xu; M A Jacobson; Zsuzsanna Wiesenfeld-Hallin; Bertil B. Fredholm
Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A3 receptors.
Neuroscience 2002;114(3):523-7.
2002: luisa lopes; Rodrigo A Cunha; Björn Kull; Bertil B. Fredholm; Joaquim Alexandre Ribeiro
Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.
Neuroscience 2002;112(2):319-29.
2001: Bertil B. Fredholm; Adriaan P IJzerman; Kenneth Alan Jacobson; Karl-Norbert Klotz; J Linden
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.
Pharmacological reviews 2001;53(4):527-52.
2001: Russell Brown; Anna Ollerstam; B Johansson; Ole Skøtt; Samuel Gebre-Medhin; Bertil B. Fredholm; A Erik G Persson
Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(5):R1362-7.
2001: Ulrika Adén; A L Leverin; H Hagberg; Bertil B. Fredholm
Adenosine A(1) receptor agonism in the immature rat brain and heart.
European journal of pharmacology 2001;426(3):185-92.
2001: Björn Johansson; Linda Halldner; Thomas V Dunwiddie; Susan A Masino; Wolfgang Poelchen; Lydia Giménez-Llort; Rosa M Escorihuela; Alberto Fernández-Teruel; Zsuzsanna Wiesenfeld-Hallin; Xiao-Jun Xu; A Hårdemark; C Betsholtz; Eric Herlenius; Bertil B. Fredholm
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9407-12.
2001: Radhika Basheer; Linda Halldner; Lauri Alanko; Robert W McCarley; Bertil B. Fredholm; Tarja Porkka-Heiskanen
Opposite changes in adenosine A1 and A2A receptor mRNA in the rat following sleep deprivation.
Neuroreport 2001;12(8):1577-80.
2001: Bertil B. Fredholm; Eva Irenius; Björn Kull; Gunnar Schulte
Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.
Biochemical pharmacology 2001;61(4):443-8.
2001: Bertil B. Fredholm; F Sjöqvist
[Pharmacology at the start of a new millennium. Larger assortment and individual drug dosing are coming].
Läkartidningen 2001;98(6):534-9.
2000: J Pintor; T Miras-Portugal; Bertil B. Fredholm
Research on purines and their receptors comes of age.
Trends in pharmacological sciences 2000;21(12):453-6.
2000: Bertil B. Fredholm; Giulia Arslan; Linda Halldner; Björn Kull; Gunnar Schulte; W Wasserman
Structure and function of adenosine receptors and their genes.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(4-5):364-74.
2000: Linda Halldner; Gianluca Lozza; Karin Lindström; Bertil B. Fredholm
Lack of tolerance to motor stimulant effects of a selective adenosine A(2A) receptor antagonist.
European journal of pharmacology 2000;406(3):345-54.
2000: Giulia Arslan; Bertil B. Fredholm
Stimulatory and inhibitory effects of adenosine A(2A) receptors on nerve growth factor-induced phosphorylation of extracellular regulated kinases 1/2 in PC12 cells.
Neuroscience letters 2000;292(3):183-6.
2000: Björn Kull; Per Svenningsson; Bertil B. Fredholm
Adenosine A(2A) receptors are colocalized with and activate g(olf) in rat striatum.
Molecular pharmacology 2000;58(4):771-7.
2000: Björn Kull; Per Svenningsson; H Hall; Bertil B. Fredholm
GTP differentially affects antagonist radioligand binding to adenosine A(1) and A(2A) receptors in human brain.
Neuropharmacology 2000;39(12):2374-80.
2000: Gunnar Schulte; Bertil B. Fredholm
Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2.
Molecular pharmacology 2000;58(3):477-82.
2000: Nancy R Zahniser; Johanna K Simosky; R Dayne Mayfield; CA Negri; Taleen Hanania; Gaynor A Larson; M A Kelly; David K Grandy; M Rubinstein; Malcolm J Low; Bertil B. Fredholm
Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(16):5949-57.
2000: Alexander V Kuzmin; B Johansson; S Semenova; Bertil B. Fredholm
Differences in the effect of chronic and acute caffeine on self-administration of cocaine in mice.
The European journal of neuroscience 2000;12(8):3026-32.
2000: Ulrika Adén; Eric Herlenius; Lie-Qi Tang; Bertil B. Fredholm
Maternal caffeine intake has minor effects on adenosine receptor ontogeny in the rat brain.
Pediatric research 2000;48(2):177-83.
2000: Robert F Berman; Bertil B. Fredholm; U Aden; William T O'Connor
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Brain research 2000;872(1-2):44-53.
2000: Robert Broad; N Fallahi; Bertil B. Fredholm
Nitric oxide interacts with oxygen free radicals to evoke the release of adenosine and adenine nucleotides from rat hippocampal slices.
Journal of the autonomic nervous system 2000;81(1-3):82-6.
2000: Per Svenningsson; Allen Fienberg; Patrick B Allen; C L Moine; Maria Lindskog; Gilberto Fisone; Paul Greengard; Bertil B. Fredholm
Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32.
Journal of neurochemistry 2000;75(1):248-57.
2000: Minna Vainio; Bertil B. Fredholm; Kid Törnquist
Thyrotropin regulates adenosine A(1) receptor expression in rat thyroid FRTL-5 cells.
British journal of pharmacology 2000;130(2):471-7.
2000: Bertil B. Fredholm
[The journey from genome structure to cure of diseases is long and winding. Research specialists in molecular biology and physiology should cooperate].
Läkartidningen 2000;97(17):2046-8.
2000: Per Svenningsson; Maria Lindskog; C Ledent; M Parmentier; Paul Greengard; Bertil B. Fredholm; Gilberto Fisone
Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1856-60.
2000: Giulia Arslan; C M Filipeanu; Eva Irenius; Björn Kull; E Clementi; Clemens Allgaier; D Erlinge; Bertil B. Fredholm
P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells.
Neuropharmacology 2000;39(3):482-96.
2000: Alexander Kuzmin; B Johansson; Bertil B. Fredholm; Sven Ove Ogren
Genetic evidence that cocaine and caffeine stimulate locomotion in mice via different mechanisms.
Life sciences 2000;66(8):PL113-8.
2000: Per Svenningsson; Bertil B. Fredholm; Bertrand Bloch; Catherine Le Moine
Co-stimulation of D(1)/D(5) and D(2) dopamine receptors leads to an increase in c-fos messenger RNA in cholinergic interneurons and a redistribution of c-fos messenger RNA in striatal projection neurons.
Neuroscience 2000;98(4):749-57.
1999: Bertil B. Fredholm
[Vademecum of a biomedical researcher: from the foundation of science to the threat from post-modern "nonsense"].
Läkartidningen 1999;96(50):5639-44.
1999: Per Svenningsson; Catherine Le Moine; Gilberto Fisone; Bertil B. Fredholm
Distribution, biochemistry and function of striatal adenosine A2A receptors.
Progress in neurobiology 1999;59(4):355-96.
1999: Björn Kull; S Ferré; Giulia Arslan; Per Svenningsson; Kjell Fuxe; C Owman; Bertil B. Fredholm
Reciprocal interactions between adenosine A2A and dopamine D2 receptors in Chinese hamster ovary cells co-transfected with the two receptors.
Biochemical pharmacology 1999;58(6):1035-45.
1999: Bertil B. Fredholm; Karin Lindström
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
European journal of pharmacology 1999;380(2-3):197-202.
1999: Alexander V Kuzmin; B Johansson; EE Zvartau; Bertil B. Fredholm
Caffeine, acting on adenosine A(1) receptors, prevents the extinction of cocaine-seeking behavior in mice.
The Journal of pharmacology and experimental therapeutics 1999;290(2):535-42.
1999: Maria Lindskog; Per Svenningsson; Bertil B. Fredholm; Paul Greengard; Gilberto Fisone
Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons.
The European journal of neuroscience 1999;11(6):2182-6.
1999: P Svenningsson; George Nomikos; Bertil B. Fredholm
The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(10):4011-22.
1999: S M Lillrank; Barbara K Lipska; Daniel R Weinberger; Bertil B. Fredholm; Kjell Fuxe; S Ferré
Adenosine and dopamine receptor antagonist binding in the rat ventral and dorsal striatum: lack of changes after a neonatal bilateral lesion of the ventral hippocampus.
Neurochemistry international 1999;34(3):235-44.
1999: Per Svenningsson; L Fourreau; Bertrand Bloch; Bertil B. Fredholm; François Gonon; Catherine Le Moine
Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons.
Neuroscience 1999;89(3):827-37.
1999: Bertil B. Fredholm; K Bättig; J Holmén; A Nehlig; E E Zvartau
Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.
Pharmacological reviews 1999;51(1):83-133.
1999: Giulia Arslan; Bertil B. Fredholm
Adenosine and P2 receptors in PC12 cells. Genotypic, phenotypic and individual differences.
Progress in brain research 1999;120():301-10.
1999: Maria Lindskog; Per Svenningsson; Bertil B. Fredholm; Paul Greengard; Gilberto Fisone
Activation of dopamine D2 receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms.
Neuroscience 1999;88(4):1005-8.
1999: Giulia Arslan; Björn Kull; Bertil B. Fredholm
Signaling via A2A adenosine receptor in four PC12 cell clones.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(1):28-32.
1999: Ennio Ongini; S Dionisotti; Stefania Gessi; E Irenius; Bertil B. Fredholm
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(1):7-10.
1999: Björn Kull; Giulia Arslan; C Nilsson; C Owman; Anna Lorenzen; Ulrich Schwabe; Bertil B. Fredholm
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors.
Biochemical pharmacology 1999;57(1):65-75.
1998: John W Daly; J Holmén; Bertil B. Fredholm
[Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine].
Läkartidningen 1998;95(51-52):5878-83.
1998: M Köhler; Svante Norgren; Per-Olof Berggren; Bertil B. Fredholm; Olle Larsson; C J Rhodes; T P Herbert; Holger Luthman
Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.
FEBS letters 1998;441(1):97-102.
1998: Per Svenningsson; Catherine Le Moine; Incarnation Aubert; P Burbaud; Bertil B. Fredholm; Bertrand Bloch
Cellular distribution of adenosine A2A receptor mRNA in the primate striatum.
The Journal of comparative neurology 1998;399(2):229-40.
1998: John W Daly; Bertil B. Fredholm
Caffeine--an atypical drug of dependence.
Drug and alcohol dependence 1998;51(1-2):199-206.
1998: Per Svenningsson; Maria Lindskog; F Rognoni; Bertil B. Fredholm; Paul Greengard; Gilberto Fisone
Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons.
Neuroscience 1998;84(1):223-8.
1998: Bertil B. Fredholm; Björn Johansson; Karin Lindström; G Wahlström
Age-dependent changes in adenosine receptors are not modified by life-long intermittent alcohol administration.
Brain research 1998;791(1-2):177-85.
1998: Bertil B. Fredholm; Karin Lindström; S Dionisotti; Ennio Ongini
[3H]SCH 58261, a selective adenosine A2A receptor antagonist, is a useful ligand in autoradiographic studies.
Journal of neurochemistry 1998;70(3):1210-6.
1998: Sergi Ferré; Maria Torvinen; K Antoniou; E Irenius; Olivier Civelli; E Arenas; Bertil B. Fredholm; Kjell Fuxe
Adenosine A1 receptor-mediated modulation of dopamine D1 receptors in stably cotransfected fibroblast cells.
The Journal of biological chemistry 1998;273(8):4718-24.
1998: Bertil B. Fredholm
[Thoughts at the start of a new year. What happens to time?].
Läkartidningen 1998;95(6):534-5.
1998: Bertil B. Fredholm; P Svenningsson
Striatal adenosine A2A receptors--where are they? What do they do?
Trends in pharmacological sciences 1998;19(2):46-8.
1998: Per Svenningsson; R Nergårdh; Bertil B. Fredholm
Regional differences in the ability of caffeine to affect haloperidol-induced striatal c-fos mRNA expression in the rat.
Neuropharmacology 1998;37(3):331-7.
1998: Karl-Norbert Klotz; J Hessling; J Hegler; C Owman; Björn Kull; Bertil B. Fredholm; Martin J Lohse
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(1):1-9.
1997: S Jin; Bertil B. Fredholm
Glucose deprivation increases basal and electrically evoked transmitter release from rat striatal slices. Role of NMDA and adenosine A1 receptors.
European journal of pharmacology 1997;340(2-3):169-75.
1997: Bertil B. Fredholm
[Our genetic differences confirm the idea on equal value of all human beings].
Läkartidningen 1997;94(49):4650-1.
1997: GE DeLander; E Schött; Ernst Brodin; Bertil B. Fredholm
Spinal expression of mRNA for immediate early genes in a model of chronic pain.
Acta physiologica Scandinavica 1997;161(4):517-25.
1997: GE DeLander; E Schött; Ernst Brodin; Bertil B. Fredholm
Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain.
Acta physiologica Scandinavica 1997;161(4):509-16.
1997: Per Svenningsson; Håkan Hall; G Sedvall; Bertil B. Fredholm
Distribution of adenosine receptors in the postmortem human brain: an extended autoradiographic study.
Synapse (New York, N.Y.) 1997;27(4):322-35.
1997: Karima Chergui; Per Svenningsson; George Nomikos; François Gonon; Bertil B. Fredholm; T H Svennson
Increased expression of NGFI-A mRNA in the rat striatum following burst stimulation of the medial forebrain bundle.
The European journal of neuroscience 1997;9(11):2370-82.
1997: Anders Kvanta; Stefan Seregard; S Sejersen; Björn Kull; Bertil B. Fredholm
Localization of adenosine receptor messenger RNAs in the rat eye.
Experimental eye research 1997;65(5):595-602.
1997: Bertil B. Fredholm
[New discoveries on adenosis and prostacyclin. Physiological processes are surveyed in genetic elimination trials].
Läkartidningen 1997;94(42):3711-2.
1997: Catherine Le Moine; Per Svenningsson; Bertil B. Fredholm; Bertrand Bloch
Dopamine-adenosine interactions in the striatum and the globus pallidus: inhibition of striatopallidal neurons through either D2 or A2A receptors enhances D1 receptor-mediated effects on c-fos expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):8038-48.
1997: Per Svenningsson; J Georgieva; E Kontny; Markus Heilig; Bertil B. Fredholm
Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum.
The European journal of neuroscience 1997;9(10):2135-41.
1997: Bertil B. Fredholm
[Political control of the universities is contra-productive and hazardous. Free universities are important for democracy].
Läkartidningen 1997;94(40):3474-7.
1997: Sergi Ferré; Bertil B. Fredholm; M Morelli; Patrizia Popoli; Kjell Fuxe
Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia.
Trends in neurosciences 1997;20(10):482-7.
1997: Björn Johansson; V Georgiev; Bertil B. Fredholm
Distribution and postnatal ontogeny of adenosine A2A receptors in rat brain: comparison with dopamine receptors.
Neuroscience 1997;80(4):1187-207.
1997: Per Svenningsson; Catherine Le Moine; Björn Kull; Roger K Sunahara; Bertrand Bloch; Bertil B. Fredholm
Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas.
Neuroscience 1997;80(4):1171-85.
1997: E Bona; U Adén; Eric Gilland; Bertil B. Fredholm; Henrik Hagberg
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists.
Neuropharmacology 1997;36(9):1327-38.
1997: Giulia Arslan; E Kontny; Bertil B. Fredholm
Down-regulation of adenosine A2A receptors upon NGF-induced differentiation of PC12 cells.
Neuropharmacology 1997;36(9):1319-26.
1997: Per Svenningsson; Bertil B. Fredholm
Caffeine mimics the effect of a dopamine D2/3 receptor agonist on the expression of immediate early genes in globus pallidus.
Neuropharmacology 1997;36(9):1309-17.
1997: S Jin; Bertil B. Fredholm
Electrically-evoked dopamine and acetylcholine release from rat striatal slices perfused without magnesium: regulation by glutamate acting on NMDA receptors.
British journal of pharmacology 1997;121(7):1269-76.
1997: Per Svenningsson; George Nomikos; Ennio Ongini; Bertil B. Fredholm
Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens.
Neuroscience 1997;79(3):753-64.
1997: Björn Johansson; V Georgiev; Karin Lindström; Bertil B. Fredholm
A1 and A2A adenosine receptors and A1 mRNA in mouse brain: effect of long-term caffeine treatment.
Brain research 1997;762(1-2):153-64.
1997: Jean W Assender; Eva Irenius; Bertil B. Fredholm
5-Hydroxytryptamine, angiotensin and bradykinin transiently increase intracellular calcium concentrations and PKC-alpha activity, but do not induce mitogenesis in human vascular smooth muscle cells.
Acta physiologica Scandinavica 1997;160(3):207-17.
1997: S Jin; Bertil B. Fredholm
Adenosine A1 receptors mediate hypoxia-induced inhibition of electrically evoked transmitter release from rat striatal slices.
European journal of pharmacology 1997;329(2-3):107-13.
1997: S Dionisotti; Ennio Ongini; C Zocchi; Björn Kull; G Arslan; Bertil B. Fredholm
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261.
British journal of pharmacology 1997;121(3):353-60.
1997: Bertil B. Fredholm
[New series: action mechanisms of drugs].
Läkartidningen 1997;94(19):1787-8.
1997: Bertil B. Fredholm; M P Abbracchio; G Burnstock; G R Dubyak; T Kendall Harden; Kenneth Alan Jacobson; Ulrich Schwabe; M Williams
Towards a revised nomenclature for P1 and P2 receptors.
Trends in pharmacological sciences 1997;18(3):79-82.
1997: Bertil B. Fredholm
Purines and neutrophil leukocytes.
General pharmacology 1997;28(3):345-50.
1997: Sharon Stone-Elander; Jan-Olov Thorell; L Eriksson; Bertil B. Fredholm; Martin Ingvar
In vivo biodistribution of [N-11C-methyl]KF 17837 using 3-D-PET: evaluation as a ligand for the study of adenosine A2A receptors.
Nuclear medicine and biology 1997;24(2):187-91.
1997: E Kontny; F Ciruela; P Svenningsson; C F Ibáñez; Bertil B. Fredholm
On the role of the low-affinity neurotrophin receptor p75LNTR in nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells.
Journal of molecular neuroscience : MN 1997;8(1):29-44.
1997: Per Svenningsson; Bertil B. Fredholm
Glucocorticoids regulate the expression of adenosine A1 but not A(2A) receptors in rat brain.
The Journal of pharmacology and experimental therapeutics 1997;280(2):1094-101.
1997: S Jin; Bertil B. Fredholm
Adenosine A2A receptor stimulation increases release of acetylcholine from rat hippocampus but not striatum, and does not affect catecholamine release.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(1):48-56.
1997: Bertil B. Fredholm
Adenosine and neuroprotection.
International review of neurobiology 1997;40():259-80.
1996: S Dasgupta; Sergi Ferré; Björn Kull; Peter B Hedlund; UB Finnman; S Ahlberg; Ernest Arenas; Bertil B. Fredholm; Kjell Fuxe
Adenosine A2A receptors modulate the binding characteristics of dopamine D2 receptors in stably cotransfected fibroblast cells.
European journal of pharmacology 1996;316(2-3):325-31.
1996: Björn Johansson; V Georgiev; T Kuosmanen; Bertil B. Fredholm
Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding.
The European journal of neuroscience 1996;8(12):2447-58.
1996: Y Zhang; Johan Raud; P Hedqvist; Bertil B. Fredholm
Propentofylline inhibits polymorphonuclear leukocyte recruitment in vivo by a mechanism involving adenosine A2A receptors.
European journal of pharmacology 1996;313(3):237-42.
1996: Ennio Ongini; Bertil B. Fredholm
Pharmacology of adenosine A2A receptors.
Trends in pharmacological sciences 1996;17(10):364-72.
1996: Karin Lindström; Ennio Ongini; Bertil B. Fredholm
The selective adenosine A2A receptor antagonist SCH 58261 discriminates between two different binding sites for [3H]-CGS 21680 in the rat brain.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(4):539-41.
1996: Bertil B. Fredholm; A Wallman-Johansson
Effects of ethanol and acetate on adenosine production in rat hippocampal slices.
Pharmacology & toxicology 1996;79(3):120-3.
1996: Bertil B. Fredholm; Y Zhang; I van der Ploeg
Adenosine A2A receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(3):262-7.
1996: J W Assender; E Irenius; Bertil B. Fredholm
Endothelin-1 causes a prolonged protein kinase C activation and acts as a co-mitogen in vascular smooth muscle cells.
Acta physiologica Scandinavica 1996;157(4):451-60.
1996: S Ferre; WT O'Connor; P Svenningsson; L Bjorklund; J Lindberg; Barbro Tinner; I Stromberg; M Goldstein; S O Ogren; U Ungerstedt; Bertil B. Fredholm; Kjell Fuxe
Dopamine D1 receptor-mediated facilitation of GABAergic neurotransmission in the rat strioentopenduncular pathway and its modulation by adenosine A1 receptor-mediated mechanisms.
The European journal of neuroscience 1996;8(7):1545-53.
1996: N Fallahi; Robert Broad; S Jin; Bertil B. Fredholm
Release of adenosine from rat hippocampal slices by nitric oxide donors.
Journal of neurochemistry 1996;67(1):186-93.
1996: H Sipma; Bertil B. Fredholm; A Den Hertog; Adriaan Nelemans
Plasma membrane Ca2+ pumping plays a prominent role in adenosine A1 receptor mediated changes in [Ca2+]i in DDT1 MF-2 cells.
European journal of pharmacology 1996;306(1-3):187-94.
1996: Olof Larsson; H Kindmark; R Brandstrom; Bertil B. Fredholm; Per-Olof Berggren
Oscillations in KATP channel activity promote oscillations in cytoplasmic free Ca2+ concentration in the pancreatic beta cell.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):5161-5.
1996: Y Zhang; J Palmblad; Bertil B. Fredholm
Biphasic effect of ATP on neutrophil functions mediated by P2U and adenosine A2A receptors.
Biochemical pharmacology 1996;51(7):957-65.
1996: Robert Broad; Bertil B. Fredholm
A1, but not A2A, adenosine receptors modulate electrically stimulated [14C]acetylcholine release from rat cortex.
The Journal of pharmacology and experimental therapeutics 1996;277(1):193-7.
1996: Kenneth Alan Jacobson; DK von Lubitz; John W Daly; Bertil B. Fredholm
Adenosine receptor ligands: differences with acute versus chronic treatment.
Trends in pharmacological sciences 1996;17(3):108-13.
1996: S Jiang; Björn Kull; Bertil B. Fredholm; S Orrenius
P2x purinoceptor is not important in thymocyte apoptosis.
Immunology letters 1996;49(3):197-201.
1996: Rodrigo A Cunha; B Johansson; MD Constantino; Ana M Sebastião; Bertil B. Fredholm
Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(3):261-71.
1996: I van der Ploeg; S Ahlberg; F E Parkinson; R A Olsson; Bertil B. Fredholm
Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(3):250-60.
1996: Bertil B. Fredholm; U Adén; Karin Lindström; E Bona; Henrik Hagberg
Caffeine and ischemia--effects on immediate early genes and adenosine receptors.
Advances in neurology 1996;71():469-74.
1996: Per Svenningsson; Björn Johansson; Bertil B. Fredholm
Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate putamen and in nucleus accumbens are differentially affected by the N-methyl-D-aspartate receptor antagonist MK-801.
Brain research. Molecular brain research 1996;35(1-2):183-9.
1996: Fiona E Parkinson; B Johansson; K Lindström; Bertil B. Fredholm
Adenosine A1 and A2A receptors and nitrobenzylthioinosine-sensitive transporters in gerbil brain: no changes following long-term treatment with the adenosine transport inhibitor propentofylline.
Neuropharmacology 1996;35(1):79-89.
1996: M Fernandez; P Svenningsson; Bertil B. Fredholm
Adaptive changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine.
Life sciences 1996;58(9):769-76.
1995: Bertil B. Fredholm
[The conscious and the unconscious olfactory perception].
Läkartidningen 1995;92(51-52):4873-6.
1995: Bertil B. Fredholm
[Should coffee be classified as a doping agent? Caffeine is definitely effective when it comes to performance capacity].
Läkartidningen 1995;92(44):4079-80.
1995: Per Svenningsson; George Nomikos; Bertil B. Fredholm
Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(11):7612-24.
1995: E Bona; U Adén; Bertil B. Fredholm; Henrik Hagberg
The effect of long term caffeine treatment on hypoxic-ischemic brain damage in the neonate.
Pediatric research 1995;38(3):312-8.
1995: Rodrigo A Cunha; B Johansson; Bertil B. Fredholm; Joaquim Alexandre Ribeiro; Ana M Sebastião
Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus.
Neuroscience letters 1995;196(1-2):41-4.
1995: J W Assender; E Irenius; Bertil B. Fredholm
Protein kinase C isoform expression and ATP response change with smooth muscle cell differentiation.
Biochemical Society transactions 1995;23(3):453S.
1995: Per Svenningsson; A Ström; Björn Johansson; Bertil B. Fredholm
Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 1):3583-93.
1995: Per Svenningsson; Björn Johansson; Bertil B. Fredholm
Effect of different xanthines and phosphodiesterase inhibitors on c-fos expression in rat striatum.
Acta physiologica Scandinavica 1995;154(1):17-24.
1995: Bertil B. Fredholm
[Hirschsprung disease. A receptor defect].
Läkartidningen 1995;92(16):1662-4.
1995: Bertil B. Fredholm; C H Heldin
[Growth factors--clarification of their mechanism].
Läkartidningen 1995;92(14):1459-62, 1467.
1995: Bertil B. Fredholm; C H Heldin
[A new series: growth factors].
Läkartidningen 1995;92(14):1454, 1457.
1995: H G Lloyd; Bertil B. Fredholm
Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices.
Neurochemistry international 1995;26(4):387-95.
1995: Bertil B. Fredholm
Purinoceptors in the nervous system.
Pharmacology & toxicology 1995;76(4):228-39.
1995: Björn Johansson; Bertil B. Fredholm
Further characterization of the binding of the adenosine receptor agonist [3H]CGS 21680 to rat brain using autoradiography.
Neuropharmacology 1995;34(4):393-403.
1995: P Gerwins; Bertil B. Fredholm
Activation of phospholipase C and phospholipase D by stimulation of adenosine A1, bradykinin or P2U receptors does not correlate well with protein kinase C activation.
Naunyn-Schmiedeberg's archives of pharmacology 1995;351(2):194-201.
1995: P Gerwins; Bertil B. Fredholm
Activation of adenosine A1 and bradykinin receptors increases protein kinase C and phospholipase D activity in smooth muscle cells.
Naunyn-Schmiedeberg's archives of pharmacology 1995;351(2):186-93.
1995: Bertil B. Fredholm
Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine.
Pharmacology & toxicology 1995;76(2):93-101.
1994: Bertil B. Fredholm
[Searching after purpose in a meaningless world].
Läkartidningen 1994;91(51-52):4871-2.
1994: Bertil B. Fredholm; A Aperia
[The 1994 Nobel Prize: discovery and significance of G-proteins].
Ugeskrift for laeger 1994;156(50):7520-4.
1994: P Snaprud; P Gerwins; Marc G Caron; F Libert; H Persson; Bertil B. Fredholm; Kjell Fuxe
A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA.
Biochemical pharmacology 1994;48(11):2043-7.
1994: Y Zhang; Bertil B. Fredholm
Propentofylline enhancement of the actions of adenosine on neutrophil leukocytes.
Biochemical pharmacology 1994;48(11):2025-32.
1994: U Adén; E Bona; Henrik Hagberg; Bertil B. Fredholm
Changes in c-fos mRNA in the neonatal rat brain following hypoxic ischemia.
Neuroscience letters 1994;180(2):91-5.
1994: Bertil B. Fredholm; A Aperia
[Nature's solution of the communication problem resulted in Nobel Prize. Significance of G-proteins for signal transmission in cells].
Läkartidningen 1994;91(42):3811-7.
1994: Fiona E Parkinson; KA Rudolphi; Bertil B. Fredholm
Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia.
General pharmacology 1994;25(6):1053-8.
1994: Peter Schubert; KA Rudolphi; Bertil B. Fredholm; Y Nakamura
Modulation of nerve and glial function by adenosine--role in the development of ischemic damage.
The International journal of biochemistry 1994;26(10-11):1227-36.
1994: S Jin; Bertil B. Fredholm
Role of NMDA, AMPA and kainate receptors in mediating glutamate- and 4-AP-induced dopamine and acetylcholine release from rat striatal slices.
Neuropharmacology 1994;33(9):1039-48.
1994: M Dunér-Engström; Bertil B. Fredholm
Carbachol-induced phosphatidylcholine hydrolysis and choline efflux in rat submandibular gland involves phospholipase D activation and is modulated by protein kinase C and calcium.
Acta physiologica Scandinavica 1994;151(4):515-25.
1994: Bertil B. Fredholm; N Altiok
Adenosine A2B receptor signalling is altered by stimulation of bradykinin or interleukin receptors in astroglioma cells.
Neurochemistry international 1994;25(1):99-102.
1994: Rodrigo A Cunha; B Johansson; I van der Ploeg; Ana M Sebastião; Joaquim Alexandre Ribeiro; Bertil B. Fredholm
Evidence for functionally important adenosine A2a receptors in the rat hippocampus.
Brain research 1994;649(1-2):208-16.
1994: U Adén; Karin Lindström; E Bona; Henrik Hagberg; Bertil B. Fredholm
Changes in adenosine receptors in the neonatal rat brain following hypoxic ischemia.
Brain research. Molecular brain research 1994;23(4):354-8.
1994: Bertil B. Fredholm; M P Abbracchio; G Burnstock; J W Daly; T Kendall Harden; Kenneth Alan Jacobson; P Leff; M Williams
Nomenclature and classification of purinoceptors.
Pharmacological reviews 1994;46(2):143-56.
1994: Björn Johansson; Karin Lindström; Bertil B. Fredholm
Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat.
Neuroscience 1994;59(4):837-49.
1994: J W Assender; E Kontny; Bertil B. Fredholm
Expression of protein kinase C isoforms in smooth muscle cells in various states of differentiation.
FEBS letters 1994;342(1):76-80.
1994: Bertil B. Fredholm
[The mechanism of acetylsalicylic acid becomes clearer].
Läkartidningen 1994;91(12):1177, 1180-1.
1994: Bertil B. Fredholm; Karin Lindström; A Wallman-Johansson
Propentofylline and other adenosine transport inhibitors increase the efflux of adenosine following electrical or metabolic stimulation of rat hippocampal slices.
Journal of neurochemistry 1994;62(2):563-73.
1994: A Wallman-Johansson; Bertil B. Fredholm
Release of adenosine and other purines from hippocampal slices stimulated electrically or by hypoxia/hypoglycemia. Effect of chlormethiazole.
Life sciences 1994;55(9):721-8.
1994: Bertil B. Fredholm
[Clarification of mechanism of acetylsalicylic acid].
Nordisk medicin 1994;109(6-7):202-3, 205.
1993: Bertil B. Fredholm
[Molecular biology and physiology go hand in hand].
Läkartidningen 1993;90(49):4420.
1993: Björn Johansson; Mario Herrera-Marschitz; P Svenningson; Bertil B. Fredholm
Caffeine-induced expression of the proto-oncogene c-fos in rat striatum is increased after dopamine denervation.
Acta physiologica Scandinavica 1993;149(4):527-9.
1993: S Jin; Björn Johansson; Bertil B. Fredholm
Effects of adenosine A1 and A2 receptor activation on electrically evoked dopamine and acetylcholine release from rat striatal slices.
The Journal of pharmacology and experimental therapeutics 1993;267(2):801-8.
1993: B Johansson; V Georgiev; F E Parkinson; Bertil B. Fredholm
The binding of the adenosine A2 receptor selective agonist [3H]CGS 21680 to rat cortex differs from its binding to rat striatum.
European journal of pharmacology 1993;247(2):103-10.
1993: M Dunér-Engström; Bertil B. Fredholm
Breakdown of membrane choline-phospholipids induced by endogenous and exogenous muscarinic agonist is potentiated by VIP in rat submandibular gland.
Acta physiologica Scandinavica 1993;149(1):41-9.
1993: H G Lloyd; K Lindström; Bertil B. Fredholm
Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion.
Neurochemistry international 1993;23(2):173-85.
1993: V Georgiev; B Johansson; Bertil B. Fredholm
Long-term caffeine treatment leads to a decreased susceptibility to NMDA-induced clonic seizures in mice without changes in adenosine A1 receptor number.
Brain research 1993;612(1-2):271-7.
1993: N Altiok; Bertil B. Fredholm
Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase.
Cellular signalling 1993;5(3):279-88.
1993: B Johansson; S Ahlberg; I van der Ploeg; Stefan Brené; Nils Lindefors; H Persson; Bertil B. Fredholm
Effect of long term caffeine treatment on A1 and A2 adenosine receptor binding and on mRNA levels in rat brain.
Naunyn-Schmiedeberg's archives of pharmacology 1993;347(4):407-14.
1993: Bertil B. Fredholm
Presynaptic regulation of hippocampal acetylcholine release is unaffected by calcium channel blockers and intracellular calcium chelation.
Acta physiologica Scandinavica 1993;147(4):461-3.
1993: Olof Larsson; C Ammälä; Krister Bokvist; Bertil B. Fredholm; Patrik Rorsman
Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells.
The Journal of physiology 1993;463():349-65.
1993: Luigi F Agnati; Kjell Fuxe; F Benfenati; G von Euler; Bertil B. Fredholm
Intramembrane receptor-receptor interactions: integration of signal transduction pathways in the nervous system.
Neurochemistry international 1993;22(3):213-22.
1993: Osten Ljunggren; Bertil B. Fredholm; C Nordstedt; Sverker Ljunghall; U H Lerner
Role of protein kinase C in bradykinin-induced prostaglandin formation in osteoblasts.
European journal of pharmacology 1993;244(2):111-7.
1993: Bertil B. Fredholm; P Gerwins; B Johansson; F E Parkinson; I van der Ploeg
Signalling via G-protein coupled receptors--using adenosine receptors as an example.
Drug design and discovery 1993;9(3-4):189-97.
1993: Bertil B. Fredholm; P S Hu
Effect of an intracellular calcium chelator on the regulation of electrically evoked [3H]-noradrenaline release from rat hippocampal slices.
British journal of pharmacology 1993;108(1):126-31.
1993: A Kvanta; Bertil B. Fredholm
Synergistic effects between protein kinase C and cAMP on activator protein-1 activity and differentiation of PC-12 pheochromocytoma cells.
Journal of molecular neuroscience : MN 1993;4(4):205-14.
1992: B Johansson; F E Parkinson; Bertil B. Fredholm
Effects of mono- and divalent ions on the binding of the adenosine analogue CGS 21680 to adenosine A2 receptors in rat striatum.
Biochemical pharmacology 1992;44(12):2365-70.
1992: B Johansson; P Svenningsson; U Adén; K Lindström; Bertil B. Fredholm
Evidence that the increase in striatal c-fos following acute high-dose caffeine is not due to direct interaction with striatal adenosine receptors.
Acta physiologica Scandinavica 1992;146(4):539-41.
1992: S Ferré; Kjell Fuxe; G von Euler; B Johansson; Bertil B. Fredholm
Adenosine-dopamine interactions in the brain.
Neuroscience 1992;51(3):501-12.
1992: KA Rudolphi; Peter Schubert; Fiona E Parkinson; Bertil B. Fredholm
Neuroprotective role of adenosine in cerebral ischaemia.
Trends in pharmacological sciences 1992;13(12):439-45.
1992: J Javier Meana; B Johansson; Mario Herrera-Marschitz; WT O'Connor; Michel Goiny; F E Parkinson; Bertil B. Fredholm; U Ungerstedt
Effect of the neurotoxin AF64A on intrinsic and extrinsic neuronal systems of rat neostriatum measured by in vivo microdialysis.
Brain research 1992;596(1-2):65-72.
1992: E Kontny; A Kvanta; Bertil B. Fredholm
Activation of protein kinase C and elevation of cAMP interact synergistically to raise c-Fos and AP-1 activity in Jurkat cells.
European journal of pharmacology 1992;227(3):333-8.
1992: M Dunér-Engström; O Larsson; Bertil B. Fredholm; L Lundblad; J Fahrenkrug; Jan M Lundberg
Effects of acute and long-term atropine treatment on levels, release and response to VIP and PHI in the submandibular gland of cat and rat.
Acta physiologica Scandinavica 1992;146(3):357-67.
1992: Bertil B. Fredholm
[Cancer mutations and normal cell regulation].
Läkartidningen 1992;89(43):3568, 3571-2.
1992: Bertil B. Fredholm
[Two share the Nobel Prize in medicine this year].
Läkartidningen 1992;89(43):3555-8; 363-4.
1992: W J Friedman; N Altiok; Bertil B. Fredholm; H Persson
Mechanisms of nerve growth factor mRNA regulation by interleukin-1 beta in hippocampal cultures: role of second messengers.
Journal of neuroscience research 1992;33(1):37-46.
1992: Anthony J Balmforth; F E Parkinson; N Altiok; Bertil B. Fredholm
Identification of a B2-bradykinin receptor linked to phospholipase C and inhibition of dopamine stimulated cyclic AMP accumulation in the human astrocytoma cell line D384.
Naunyn-Schmiedeberg's archives of pharmacology 1992;346(3):303-10.
1992: N Altiok; Bertil B. Fredholm
Bradykinin inhibition of cyclic AMP accumulation in D384 astrocytoma cells. Evidence against a role of cyclic GMP.
Neurochemistry international 1992;21(2):209-13.
1992: P Gerwins; Bertil B. Fredholm
Stimulation of adenosine A1 receptors and bradykinin receptors, which act via different G proteins, synergistically raises inositol 1,4,5-trisphosphate and intracellular free calcium in DDT1 MF-2 smooth muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7330-4.
1992: P Gerwins; Bertil B. Fredholm
ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line.
The Journal of biological chemistry 1992;267(23):16081-7.
1992: Bertil B. Fredholm
[The NSAID gastropathy--a new hypothesis on the etiology].
Läkartidningen 1992;89(28-29):2421-2.
1992: A Kvanta; E Kontny; Mikael Jondal; S Okret; Bertil B. Fredholm
Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity.
Cellular signalling 1992;4(3):275-86.
1992: P S Hu; S Jin; Bertil B. Fredholm
Glycine and GABA potentiate 4-aminopyridine and/or N-methyl-D-aspartate induced [3H]-noradrenaline release from rat hippocampal slices.
Acta physiologica Scandinavica 1992;145(1):77-8.
1992: I van der Ploeg; F E Parkinson; Bertil B. Fredholm
Effect of pertussis toxin on radioligand binding to rat brain adenosine A1 receptors.
Journal of neurochemistry 1992;58(4):1221-9.
1992: F E Parkinson; Bertil B. Fredholm
Magnesium-dependent enhancement of endogenous agonist binding to A1 adenosine receptors: a complicating factor in quantitative autoradiography.
Journal of neurochemistry 1992;58(3):941-50.
1992: Bertil B. Fredholm; I Krakau
[Studies of prescriptions--a starting-point for scientific work].
Läkartidningen 1992;89(1-2):20-1.
1992: Bertil B. Fredholm; J Fastbom; A Kvanta; P Gerwins; F Parkinson
Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport.
Fundamental & clinical pharmacology 1992;6(3):99-111.
1992: KA Rudolphi; Peter Schubert; Fiona E Parkinson; Bertil B. Fredholm
Adenosine and brain ischemia.
Cerebrovascular and brain metabolism reviews 1992;4(4):346-69.
1992: N Altiok; Anthony J Balmforth; Bertil B. Fredholm
Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon.
Acta physiologica Scandinavica 1992;144(1):55-63.
1991: P S Hu; C Benishin; Bertil B. Fredholm
Comparison of the effects of four dendrotoxin peptides, 4-aminopyridine and tetraethylammonium on the electrically evoked [3H]noradrenaline release from rat hippocampus.
European journal of pharmacology 1991;209(1-2):87-93.
1991: I van der Ploeg; N Altiok; A Kvanta; C Nordstedt; Bertil B. Fredholm
Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(5):611-7.
1991: Bertil B. Fredholm
[The molecular background of our capacity to identify smells].
Läkartidningen 1991;88(42):3467-8.
1991: F E Parkinson; Bertil B. Fredholm
Effects of propentofylline on adenosine A1 and A2 receptors and nitrobenzylthioinosine-sensitive nucleoside transporters: quantitative autoradiographic analysis.
European journal of pharmacology 1991;202(3):361-6.
1991: P Rorsman; Bertil B. Fredholm
[Ion channels--the molecular background of neural transmission].
Läkartidningen 1991;88(36):2868-77.
1991: P S Hu; S Jin; Bertil B. Fredholm
4-Aminopyridine-induced noradrenaline release from the rat hippocampus depends on the activation of glutamate receptors of the non-NMDA type.
Acta physiologica Scandinavica 1991;143(1):139-40.
1991: S Ferre; Gabriel von Euler; B Johansson; Bertil B. Fredholm; Kjell Fuxe
Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7238-41.
1991: P Gerwins; Bertil B. Fredholm
Glucocorticoid receptor activation leads to up-regulation of adenosine A1 receptors and down-regulation of adenosine A2 responses in DDT1 MF-2 smooth muscle cells.
Molecular pharmacology 1991;40(2):149-55.
1991: A Kvanta; Mikael Jondal; Bertil B. Fredholm
CD3-dependent increase in cyclic AMP in human T-cells following stimulation of the CD2 receptor.
Biochimica et biophysica acta 1991;1093(2-3):178-83.
1991: A Kvanta; Mikael Jondal; Bertil B. Fredholm
Translocation of the alpha- and beta-isoforms of protein kinase C following activation of human T-lymphocytes.
FEBS letters 1991;283(2):321-4.
1991: O Ljunggren; Bertil B. Fredholm; Ulf H Lerner
On the role of polyamines in bone resorption induced by parathyroid hormone.
Acta physiologica Scandinavica 1991;142(2):267-73.
1991: M Ballarín; Bertil B. Fredholm; Santiago Ambrosio; Nicole Mahy
Extracellular levels of adenosine and its metabolites in the striatum of awake rats: inhibition of uptake and metabolism.
Acta physiologica Scandinavica 1991;142(1):97-103.
1991: I Van der Ploeg; Bertil B. Fredholm; M Carlquist; A Bertorello; A Aperia; G Celsi
Localization of several G-protein subunits to the apical and basolateral membranes of cortical tubular cells from the rat kidney.
Acta physiologica Scandinavica 1991;142(1):83-90.
1991: Osten Ljunggren; H Johansson; S Ljunghall; Bertil B. Fredholm; Ulf H Lerner
Bradykinin induces formation of inositol phosphates and causes an increase in cytoplasmic Ca2+ in the osteoblastic cell line MC3T3-E1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6(5):443-52.
1991: Bertil B. Fredholm
Diversity in receptor signalling: cellular individuality and the search for selective drugs.
Journal of internal medicine 1991;229(5):391-406.
1991: C O Stiller; J Fastbom; Bertil B. Fredholm; E Brodin
The adenosine analogue R-PIA interacts with substance P binding in rat brain and spinal cord.
Acta physiologica Scandinavica 1991;141(4):573-4.
1991: P S Hu; Bertil B. Fredholm
4-Aminopyridine-induced increase in basal and stimulation-evoked [3H]-NA release in slices from rat hippocampus: Ca2+ sensitivity and presynaptic control.
British journal of pharmacology 1991;102(3):764-8.
1991: Bertil B. Fredholm
[Molecular pharmacology--the road to selective pharmacotherapy?].
Läkartidningen 1991;88(6):413-4, 417-21.
1991: Gabriel von Euler; I van der Ploeg; Bertil B. Fredholm; Kjell Fuxe
Neurotensin decreases the affinity of dopamine D2 agonist binding by a G protein-independent mechanism.
Journal of neurochemistry 1991;56(1):178-83.
1991: I van der Ploeg; A Cintra; N Altiok; P Askelöf; Kjell Fuxe; Bertil B. Fredholm
Limited distribution of pertussis toxin in rat brain after injection into the lateral cerebral ventricles.
Neuroscience 1991;44(1):205-14.
1990: A Kvanta; P Gerwins; I van der Ploeg; C Nordstedt; Mikael Jondal; Bertil B. Fredholm
Stimulation of the T-cell receptors CD3 and CD2 with OKT3 and OKT11 antibodies activates a common pertussis toxin-insensitive G-protein.
European journal of pharmacology 1990;189(6):363-72.
1990: O Larsson; T Detsch; Bertil B. Fredholm
VIP and forskolin enhance carbachol-induced K+ efflux from rat salivary gland fragments by a Ca2(+)-sensitive mechanism.
The American journal of physiology 1990;259(6 Pt 1):C904-10.
1990: P Gerwins; C Nordstedt; Bertil B. Fredholm
Characterization of adenosine A1 receptors in intact DDT1 MF-2 smooth muscle cells.
Molecular pharmacology 1990;38(5):660-6.
1990: Bertil B. Fredholm
Adenosine A1-receptor-mediated inhibition of evoked acetylcholine release in the rat hippocampus does not depend on protein kinase C.
Acta physiologica Scandinavica 1990;140(2):245-55.
1990: C Nordstedt; Bertil B. Fredholm
A modification of a protein-binding method for rapid quantification of cAMP in cell-culture supernatants and body fluid.
Analytical biochemistry 1990;189(2):231-4.
1990: P Andiné; K A Rudolphi; Bertil B. Fredholm; Henrik Hagberg
Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia.
British journal of pharmacology 1990;100(4):814-8.
1990: F E Parkinson; Bertil B. Fredholm
Autoradiographic evidence for G-protein coupled A2-receptors in rat neostriatum using [3H]-CGS 21680 as a ligand.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(1):85-9.
1990: E Dux; J Fastbom; U Ungerstedt; K Rudolphi; Bertil B. Fredholm
Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus.
Brain research 1990;516(2):248-56.
1990: Bertil B. Fredholm; A Abbott
New targets for drug action: is high selectivity always beneficial?
Trends in pharmacological sciences 1990;11(5):175-8.
1990: Bertil B. Fredholm
Differential sensitivity to blockade by 4-aminopyridine of presynaptic receptors regulating [3H]acetylcholine release from rat hippocampus.
Journal of neurochemistry 1990;54(4):1386-90.
1990: J Fastbom; Bertil B. Fredholm
Effects of long-term theophylline treatment on adenosine A1-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins.
Brain research 1990;507(2):195-9.
1990: J Fastbom; Bertil B. Fredholm
Regional differences in the effect of guanine nucleotides on agonist and antagonist binding to adenosine A1-receptors in rat brain, as revealed by autoradiography.
Neuroscience 1990;34(3):759-69.
1990: J Fastbom; C Post; Bertil B. Fredholm
Antinociceptive effects and spinal distribution of two adenosine receptor agonists after intrathecal administration.
Pharmacology & toxicology 1990;66(1):69-72.
1990: A Kvanta; C Nordstedt; Bertil B. Fredholm; M Gullberg; Mikael Jondal
Evidence that protein kinase C activation is essential for killing by IL-2-activated lymphocytes.
Scandinavian journal of immunology 1990;31(1):103-8.
1990: A Kvanta; P Gerwins; Mikael Jondal; Bertil B. Fredholm
Stimulation of T-cells with OKT3 antibodies increases forskolin binding and cyclic AMP accumulation.
Cellular signalling 1990;2(5):461-70.
1990: Bertil B. Fredholm; M Dunér-Engström; J Fastbom; P S Hu; I van der Ploeg
Role of G proteins, cyclic AMP, and ion channels in the inhibition of transmitter release by adenosine.
Annals of the New York Academy of Sciences 1990;604():276-88.
1989: Gabriel von Euler; Kjell Fuxe; I Van der Ploeg; Bertil B. Fredholm; Luigi F Agnati
Pertussis toxin treatment counteracts intramembrane interactions between neuropeptide Y receptors and alpha 2-adrenoceptors.
European journal of pharmacology 1989;172(6):435-41.
1989: A Kvanta; C Nordstedt; Mikael Jondal; Bertil B. Fredholm
Activation of protein kinase C via the T-cell receptor complex potentiates cyclic AMP responses in T-cells.
Naunyn-Schmiedeberg's archives of pharmacology 1989;340(6 Pt 2):715-7.
1989: Bertil B. Fredholm; M Dunér-Engström
Propentofylline and a hydroxy metabolite augment A2-receptor mediated cyclic AMP accumulation and attenuate A1-receptor mediated inhibition of acetylcholine release in the rat hippocampus.
Pharmacology & toxicology 1989;65(5):347-51.
1989: K A Rudolphi; M Keil; J Fastbom; Bertil B. Fredholm
Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment.
Neuroscience letters 1989;103(3):275-80.
1989: Bertil B. Fredholm; W Proctor; I Van der Ploeg; T V Dunwiddie
In vivo pertussis toxin treatment attenuates some, but not all, adenosine A1 effects in slices of the rat hippocampus.
European journal of pharmacology 1989;172(3):249-62.
1989: Bertil B. Fredholm
[Reflections on 2 cases of scientific fraud. Give norms for good research. Guard scientific ethics].
Läkartidningen 1989;86(32-33):2686-7.
1989: M Runold; Hugo Lagercrantz; Nanduri R Prabhakar; Bertil B. Fredholm
Role of adenosine in hypoxic ventilatory depression.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(2):541-6.
1989: T W Stone; Bertil B. Fredholm; John W Phillis
Adenosine and morphine.
Trends in pharmacological sciences 1989;10(8):316.
1989: A Kvanta; C Nordstedt; I van der Ploeg; Mikael Jondal; Bertil B. Fredholm
CD3/T-cell receptor coupling to a pertussis and cholera toxin-insensitive G-protein.
FEBS letters 1989;250(2):536-40.
1989: Kjell Fuxe; Gabriel von Euler; I van der Ploeg; Bertil B. Fredholm; Luigi F Agnati
Pertussis toxin treatment counteracts the cardiovascular effects of neuropeptide Y and clonidine in the awake unrestrained rat.
Neuroscience letters 1989;101(3):337-41.
1989: P S Hu; Bertil B. Fredholm
Alpha 2-adrenoceptor agonist-mediated inhibition of [3H]noradrenaline release from rat hippocampus is reduced by 4-aminopyridine, but that caused by an adenosine analogue or omega-conotoxin is not.
Acta physiologica Scandinavica 1989;136(3):347-53.
1989: Thomas V Dunwiddie; Bertil B. Fredholm
Adenosine A1 receptors inhibit adenylate cyclase activity and neurotransmitter release and hyperpolarize pyramidal neurons in rat hippocampus.
The Journal of pharmacology and experimental therapeutics 1989;249(1):31-7.
1989: C Nordstedt; A Kvanta; I Van der Ploeg; Bertil B. Fredholm
Dual effects of protein kinase-C on receptor-stimulated cAMP accumulation in a human T-cell leukemia line.
European journal of pharmacology 1989;172(1):51-60.
1989: O Larsson; Bertil B. Fredholm
Carbachol stimulation of inositol phosphate accumulation in rat submandibular gland fragments is not modified by VIP.
Acta physiologica Scandinavica 1989;135(3):263-9.
1989: P Lönnroth; Per-Anders Jansson; Bertil B. Fredholm; Ulf Smith
Microdialysis of intercellular adenosine concentration in subcutaneous tissue in humans.
The American journal of physiology 1989;256(2 Pt 1):E250-5.
1989: Ulf H Lerner; Maria Ransjö; K Sahlberg; Osten Ljunggren; Bertil B. Fredholm
Forskolin sensitizes parathyroid hormone-induced cyclic AMP response, but not the bone resorptive effect, in mouse calvarial bones.
Bone and mineral 1989;5(2):169-81.
1989: A Härfstrand; Kjell Fuxe; Luigi F Agnati; Bertil B. Fredholm
Reciprocal interactions between alpha 2-adrenoceptor agonist and neuropeptide Y binding sites in the nucleus tractus solitarius of the rat. A biochemic and autoradiographic analysis.
Journal of neural transmission 1989;75(2):83-99.
1988: C Nordstedt; A Kvanta; Bertil B. Fredholm
Agonist but not phorbol ester induced desensitization of human lymphocyte prostaglandin receptor is dependent on tubulin polymerization.
Biochemical and biophysical research communications 1988;157(3):1046-50.
1988: J Ng; Bertil B. Fredholm; Mikael Jondal; T Andersson
Regulation of receptor-mediated calcium influx across the plasma membrane in a human leukemic T-cell line: evidence of its dependence on an initial calcium mobilization from intracellular stores.
Biochimica et biophysica acta 1988;971(2):207-14.
1988: Christer Sylvén; B Jonzon; Bertil B. Fredholm; L Kaijser
Adenosine injection into the brachial artery produces ischaemia like pain or discomfort in the forearm.
Cardiovascular research 1988;22(9):674-8.
1988: M Dunér-Engström; Bertil B. Fredholm
Evidence that prejunctional adenosine receptors regulating acetylcholine release from rat hippocampal slices are linked to an N-ethylmaleimide-sensitive G-protein, but not to adenylate cyclase or dihydropyridine-sensitive Ca2+-channels.
Acta physiologica Scandinavica 1988;134(1):119-26.
1988: Bertil B. Fredholm
[Homeopathy in the dog-days--how to refresh our memory?].
Läkartidningen 1988;85(35):2723, 2726.
1988: Bertil B. Fredholm; C Nordstedt; I van der Ploeg
[New discoveries on receptor mechanisms--disease-related changes were detected].
Läkartidningen 1988;85(25):2251-4.
1988: S C Chow; J NG; C Nordstedt; Bertil B. Fredholm; Mikael Jondal
Phosphoinositide breakdown and evidence for protein kinase C involvement during human NK killing.
Cellular immunology 1988;114(1):96-103.
1988: Bertil B. Fredholm
[Coffee, caffeine and the heart--heart disease].
Läkartidningen 1988;85(21):1869-73.
1988: Bertil B. Fredholm; E Lindgren
Protein kinase C activation increases noradrenaline release from the rat hippocampus and modifies the inhibitory effect of alpha 2-adrenoceptor and adenosine A1-receptor agonists.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(5):477-83.
1988: M Wennmalm; Bertil B. Fredholm; P Hedqvist
Adenosine as a modulator of sympathetic nerve-stimulation-induced release of noradrenaline from the isolated rabbit heart.
Acta physiologica Scandinavica 1988;132(4):487-94.
1988: Bertil B. Fredholm; T V Dunwiddie
How does adenosine inhibit transmitter release?
Trends in pharmacological sciences 1988;9(4):130-4.
1988: Jan M Lundberg; A Hemsén; Anders Rudehill; A Härfstrand; O Larsson; A Sollevi; Alois Saria; Tomas Hökfelt; Kjell Fuxe; Bertil B. Fredholm
Neuropeptide Y- and alpha-adrenergic receptors in pig spleen: localization, binding characteristics, cyclic AMP effects and functional responses in control and denervated animals.
Neuroscience 1988;24(2):659-72.
1988: Jan M Lundberg; A Hemsén; O Larsson; Anders Rudehill; Alois Saria; Bertil B. Fredholm
Neuropeptide Y receptor in pig spleen: binding characteristics, reduction of cyclic AMP formation and calcium antagonist inhibition of vasoconstriction.
European journal of pharmacology 1988;145(1):21-9.
1988: L Nylund; NO Lunell; B Persson; Bertil B. Fredholm; H Lagercrantz
Smoking exerts a ketogenic influence in diabetic pregnancy.
Gynecologic and obstetric investigation 1988;25(1):35-7.
1988: Maria Ransjö; Bertil B. Fredholm; Ulf H Lerner
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Bone and mineral 1988;3(3):225-34.
1987: Bertil B. Fredholm; E Lindgren; K Lindström; C Nordstedt
Alpha-adrenoceptor stimulation, but not muscarinic stimulation, increases cyclic AMP accumulation in brain slices due to protein kinase C mediated enhancement of adenosine receptor effects.
Acta physiologica Scandinavica 1987;131(4):543-51.
1987: I R Moss; M Runold; I Dahlin; Bertil B. Fredholm; Fred Nyberg; Hugo Lagercrantz
Respiratory and neuroendocrine responses of piglets to hypoxia during postnatal development.
Acta physiologica Scandinavica 1987;131(4):533-41.
1987: J Häggblad; Bertil B. Fredholm
Adenosine and neuropeptide Y enhance alpha 1-adrenoceptor-induced accumulation of inositol phosphates and attenuate forskolin-induced accumulation of cyclic AMP in rat vas deferens.
Neuroscience letters 1987;82(2):211-6.
1987: J Ng; Bertil B. Fredholm; Mikael Jondal
Studies on the calcium dependence of human NK cell killing.
Biochemical pharmacology 1987;36(22):3943-9.
1987: J Fastbom; Bertil B. Fredholm
Regional differences in the GTP-dependence of adenosine receptor binding in rat brain?
Acta physiologica Scandinavica 1987;131(3):467-9.
1987: Ulf H Lerner; K Sahlberg; Bertil B. Fredholm
Characterization of adenosine receptors in bone. Studies on the effect of adenosine analogues on cyclic AMP formation and bone resorption in cultured mouse calvaria.
Acta physiologica Scandinavica 1987;131(2):287-96.
1987: Bertil B. Fredholm
Analysis of purines.
Life sciences 1987;41(7):837-40.
1987: C Nordstedt; M Jondal; Bertil B. Fredholm
Activation of protein kinase C inhibits prostaglandin- and potentiates adenosine receptor-stimulated accumulation of cyclic AMP in a human T-cell leukemia line.
FEBS letters 1987;220(1):57-60.
1987: P S Hu; E Lindgren; Kenneth Alan Jacobson; Bertil B. Fredholm
Interaction of dihydropyridine calcium channel agonists and antagonists with adenosine receptors.
Pharmacology & toxicology 1987;61(2):121-5.
1987: Mark S Brodie; K Lee; Bertil B. Fredholm; L Ståhle; T V Dunwiddie
Central versus peripheral mediation of responses to adenosine receptor agonists: evidence against a central mode of action.
Brain research 1987;415(2):323-30.
1987: J Thyberg; Bertil B. Fredholm
Induction of ornithine decarboxylase activity and putrescine synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor.
Experimental cell research 1987;170(1):160-9.
1986: Bertil B. Fredholm; P S Hu; E Lindgren
The dihydropyridine calcium-channel agonist BayK 8644 inhibits the presynaptic effects of R-phenylisopropyl adenosine in the rat hippocampus.
Acta physiologica Scandinavica 1986;128(4):659-60.