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Karl Kadler

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Zoher Kapacee; Ching-Yan Chloé Yeung; Yinhui Lu; David Crabtree; David F Holmes; Karl Kadler
Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3.
Nicholas S Kalson; David F Holmes; Zoher Kapacee; Iker Otermin; Yinhui Lu; Roland A Ennos; Elizabeth G Canty-Laird; Karl Kadler
An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery.
J K F Wong; S Alyouha; Karl Kadler; M W J Ferguson; D Angus McGrouther
The cell biology of suturing tendons.

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2010: Zoher Kapacee; Ching-Yan Chloé Yeung; Yinhui Lu; David Crabtree; David F Holmes; Karl Kadler
Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3.
Matrix biology : journal of the International Society for Matrix Biology 2010;29(8):668-77.
2010: Nicholas S Kalson; David F Holmes; Zoher Kapacee; Iker Otermin; Yinhui Lu; Roland A Ennos; Elizabeth G Canty-Laird; Karl Kadler
An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery.
Matrix biology : journal of the International Society for Matrix Biology 2010;29(8):678-89.
2010: J K F Wong; S Alyouha; Karl Kadler; M W J Ferguson; D Angus McGrouther
The cell biology of suturing tendons.
Matrix biology : journal of the International Society for Matrix Biology 2010;29(6):525-36.
2010: Elizabeth Canty-Laird; Gwenn-Aël Carré; Béatrice Mandon-Pépin; Karl Kadler; Stéphane Fabre
First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles.
Biology of reproduction 2010;83(1):138-46.
2010: Antonio Inforzato; Clair Baldock; Thomas A Jowitt; David F Holmes; Ragnar Lindstedt; Marcella Marcellini; Vincenzo Rivieccio; David Briggs; Karl Kadler; Antonio Verdoliva ; Barbara Bottazzi; Alberto Mantovani; Giovanni Salvatori; Anthony J Day
The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2.
The Journal of biological chemistry 2010;285(23):17681-92.
2010: Monika L Bayer; Chin-Yan C Yeung; Karl Kadler; Klaus Qvortrup; Keith Baar; René B Svensson; S Peter Magnusson; Michael Krogsgaard; Manuel Koch; Michael Kjaer
The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension.
Biomaterials 2010;31(18):4889-97.
2010: David F Holmes; Alexander Tait; Nigel Hodson; Michael J Sherratt; Karl Kadler
Growth of collagen fibril seeds from embryonic tendon: fractured fibril ends nucleate new tip growth.
Journal of molecular biology 2010;399(1):9-16.
2010: Richard Berry; Thomas A Jowitt; laure garrigue-antar; Karl Kadler; Clair Baldock
Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase.
FEBS letters 2010;584(4):657-61.
2010: Katarzyna Piróg; Oihane Jaka; Yoshihisa Katakura; Roger S Meadows; Karl Kadler; Raymond P Boot-Handford; Michael D Briggs
A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia.
Human molecular genetics 2010;19(1):52-64.
2009: Jason K F Wong; Yin H Lui; Zoher Kapacee; Karl Kadler; Mark W J Ferguson; Duncan A McGrouther
The cellular biology of flexor tendon adhesion formation: an old problem in a new paradigm.
The American journal of pathology 2009;175(5):1938-51.
2009: M Helen Rajpar; Ben McDermott; Louise Kung; Rachel Eardley; Lynette Knowles; Mel Heeran; David J Thornton; Richard Wilson; John F Bateman; Richard Poulsom; Peter Arvan; Karl Kadler; Michael D Briggs; Raymond P Boot-Handford
Targeted induction of endoplasmic reticulum stress induces cartilage pathology.
PLoS genetics 2009;5(10):e1000691.
2009: Tobias Starborg; Yinhui Lu; A Huffman; David F Holmes; Karl Kadler
Electron microscope 3D reconstruction of branched collagen fibrils in vivo.
Scandinavian journal of medicine & science in sports 2009;19(4):547-52.
2009: Richard Berry; Thomas A Jowitt; Johanna Ferrand; Manfred Roessle; J Günter Grossmann; Elizabeth G Canty-Laird; Richard A Kammerer; Karl Kadler; Clair Baldock
Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8561-6.
2008: Agata K Levay; Jacqueline D Peacock; Yinhui Lu; Manuel Koch; Robert B Hinton; Karl Kadler; Joy Lincoln
Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo.
Circulation research 2008;103(9):948-56.
2008: Jacqueline D Peacock; Yinhui Lu; Manuel Koch; Karl Kadler; Joy Lincoln
Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(10):3051-8.
2008: Karl Kadler; Adele Hill; Elizabeth G Canty-Laird
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators.
Current opinion in cell biology 2008;20(5):495-501.
2008: Sally M Humphries; Yinhui Lu; Elizabeth G Canty; Karl Kadler
Active negative control of collagen fibrillogenesis in vivo. Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils.
The Journal of biological chemistry 2008;283(18):12129-35.
2008: Tobias Starborg; Yinhui Lu; Roger S Meadows; Karl Kadler; David F Holmes
Electron microscopy in cell-matrix research.
Methods (San Diego, Calif.) 2008;45(1):53-64.
2008: Zoher Kapacee; Susan H Richardson; Yinhui Lu; Tobias Starborg; David F Holmes; Keith Baar; Karl Kadler
Tension is required for fibripositor formation.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(4):371-5.
2008: K L Goh; D F Holmes; H-Y Lu; S Richardson; Karl Kadler; P P Purslow; T J Wess
Ageing changes in the tensile properties of tendons: influence of collagen fibril volume fraction.
Journal of biomechanical engineering 2008;130(2):021011.
2008: Anne Vaughan-Thomas; Jayesh Dudhia; Michael T Bayliss; Karl Kadler; Victor C Duance
Modification of the composition of articular cartilage collagen fibrils with increasing age.
Connective tissue research 2008;49(5):374-82.
2008: Tobias Starborg; Yinhui Lu; Karl Kadler; David F Holmes
Electron microscopy of collagen fibril structure in vitro and in vivo including three-dimensional reconstruction.
Methods in cell biology 2008;88():319-45.
2007: Katarzyna Piróg; Roger S Meadows; Lynette Knowles; Dick Heinegård; David J Thornton; Karl Kadler; Raymond P Boot-Handford; Michael D Briggs
Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.
Human molecular genetics 2007;16(17):2072-88.
2007: Susan H Richardson; Tobias Starborg; Yinhui Lu; Sally M Humphries; Roger S Meadows; Karl Kadler
Tendon development requires regulation of cell condensation and cell shape via cadherin-11-mediated cell-cell junctions.
Molecular and cellular biology 2007;27(17):6218-28.
2007: Matthew P Leighton; Seema Nundlall; Tobias Starborg; Roger S Meadows; Farhana Suleman; Lynette Knowles; Raimund Wagener; David J Thornton; Karl Kadler; Raymond P Boot-Handford; Michael D Briggs
Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.
Human molecular genetics 2007;16(14):1728-41.
2007: Karl Kadler; Clair Baldock; Jordi Bella; Raymond P Boot-Handford
Collagens at a glance.
Journal of cell science 2007;120(Pt 12):1955-8.
2007: Karl Kadler
Collagen pretzels revealed by electron microscopy.
The Biochemical journal 2007;404(3):e7-8.
2007: Darren A Plumb; Vivek Dhir; Aleksandr Mironov; Laila Ferrara; Richard Poulsom; Karl Kadler; David J Thornton; Michael D Briggs; Raymond P Boot-Handford
Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens.
The Journal of biological chemistry 2007;282(17):12791-5.
2006: Elizabeth G Canty; Tobias Starborg; Yinhui Lu; Sally M Humphries; David F Holmes; Roger S Meadows; Adam Huffman; Eileen T O'Toole; Karl Kadler
Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon.
The Journal of biological chemistry 2006;281(50):38592-8.
2006: David F Holmes; Karl Kadler
The 10+4 microfibril structure of thin cartilage fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17249-54.
2006: Elizabeth G Canty; laure garrigue-antar; Karl Kadler
A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation.
The Journal of biological chemistry 2006;281(19):13258-67.
2005: Vasiliki Petropoulou; laure garrigue-antar; Karl Kadler
Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1).
The Journal of biological chemistry 2005;280(24):22616-23.
2005: Elizabeth G Canty; Karl Kadler
Procollagen trafficking, processing and fibrillogenesis.
Journal of cell science 2005;118(Pt 7):1341-53.
2005: Kheng Lim Goh; Jennifer Hiller; J Louise Haston; David F Holmes; Karl Kadler; Ann Murdoch; Judith R Meakin; Tim J Wess
Analysis of collagen fibril diameter distribution in connective tissues using small-angle X-ray scattering.
Biochimica et biophysica acta 2005;1722(2):183-8.
2005: David F Holmes; Karl Kadler
The precision of lateral size control in the assembly of corneal collagen fibrils.
Journal of molecular biology 2005;345(4):773-84.
2004: laure garrigue-antar; Vincent François; Karl Kadler
Deletion of epidermal growth factor-like domains converts mammalian tolloid into a chordinase and effective procollagen C-proteinase.
The Journal of biological chemistry 2004;279(48):49835-41.
2004: Elizabeth G Canty; Yinhui Lu; Roger S Meadows; Michael K Shaw; David F Holmes; Karl Kadler
Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon.
The Journal of cell biology 2004;165(4):553-63.
2004: Paul N Bishop; David F Holmes; Karl Kadler; david mcleod; Kees Jan Bos
Age-related changes on the surface of vitreous collagen fibrils.
Investigative ophthalmology & visual science 2004;45(4):1041-6.
2004: Karl Kadler
Matrix loading: assembly of extracellular matrix collagen fibrils during embryogenesis.
Birth defects research. Part C, Embryo today : reviews 2004;72(1):1-11.
2003: Matthew P Leighton; Karl Kadler
Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network.
The Journal of biological chemistry 2003;278(20):18478-84.
2003: Nichola Hartigan; laure garrigue-antar; Karl Kadler
Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity.
The Journal of biological chemistry 2003;278(20):18045-9.
2002: Elizabeth G Canty; Karl Kadler
Collagen fibril biosynthesis in tendon: a review and recent insights.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2002;133(4):979-85.
2002: laure garrigue-antar; Nichola Hartigan; Karl Kadler
Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein.
The Journal of biological chemistry 2002;277(45):43327-34.
2002: Anke Rattenholl; William N Pappano; Manuel Koch; Douglas R Keene; Karl Kadler; Takako Sasaki; Rupert Timpl; Robert E Burgeson; Daniel S Greenspan; Leena Bruckner-Tuderman
Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen.
The Journal of biological chemistry 2002;277(29):26372-8.
2002: Clair Baldock; CJ Gilpin; Abraham Koster; Ulrike Ziese; Karl Kadler; Cay M Kielty; David F Holmes
Three-dimensional reconstructions of extracellular matrix polymers using automated electron tomography.
Journal of structural biology 2002;138(1-2):130-6.
2001: laure garrigue-antar; C Barker; Karl Kadler
Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.
The Journal of biological chemistry 2001;276(28):26237-42.
2001: David F Holmes; CJ Gilpin; Clair Baldock; Ulrike Ziese; Abraham Koster; Karl Kadler
Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7307-12.
2001: Kees Jan Bos; David F Holmes; Roger S Meadows; Karl Kadler; david mcleod; Paul N Bishop
Collagen fibril organisation in mammalian vitreous by freeze etch/rotary shadowing electron microscopy.
Micron (Oxford, England : 1993) 2001;32(3):301-6.
2001: David F Holmes; HK Graham; John A Trotter; Karl Kadler
STEM/TEM studies of collagen fibril assembly.
Micron (Oxford, England : 1993) 2001;32(3):273-85.
2001: Kees Jan Bos; David F Holmes; Karl Kadler; david mcleod; N P Morris; Paul N Bishop
Axial structure of the heterotypic collagen fibrils of vitreous humour and cartilage.
Journal of molecular biology 2001;306(5):1011-22.
2001: Clair Baldock; Abraham Koster; Ulrike Ziese; Matthew J Rock; Michael J Sherratt; Karl Kadler; C Adrian Shuttleworth; Cay M Kielty
The supramolecular organization of fibrillin-rich microfibrils.
The Journal of cell biology 2001;152(5):1045-56.
2001: P Holden; Roger S Meadows; Kathryn L Chapman; Michael E Grant; Karl Kadler; Michael D Briggs
Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family.
The Journal of biological chemistry 2001;276(8):6046-55.
2000: A Ovens; J A Joule; Karl Kadler
Design and synthesis of acidic dipeptide hydroxamate inhibitors of procollagen C-proteinase.
Journal of peptide science : an official publication of the European Peptide Society 2000;6(9):489-95.
2000: Karl Kadler; David F Holmes; H Graham; Tobias Starborg
Tip-mediated fusion involving unipolar collagen fibrils accounts for rapid fibril elongation, the occurrence of fibrillar branched networks in skin and the paucity of collagen fibril ends in vertebrates.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(4):359-65.
2000: John A Trotter; Karl Kadler; David F Holmes
Echinoderm collagen fibrils grow by surface-nucleation-and-propagation from both centers and ends.
Journal of molecular biology 2000;300(3):531-40.
2000: HK Graham; David F Holmes; Rod B Watson; Karl Kadler
Identification of collagen fibril fusion during vertebrate tendon morphogenesis. The process relies on unipolar fibrils and is regulated by collagen-proteoglycan interaction.
Journal of molecular biology 2000;295(4):891-902.
2000: John A Trotter; J Tipper; Gillian Lyons-Levy; K Chino; A H Heuer; Z Liu; M Mrksich; Christian D Hodneland; W Shannon Dillmore; Thomas J Koob; M M Koob-Emunds; Karl Kadler; D Holmes
Towards a fibrous composite with dynamically controlled stiffness: lessons from echinoderms.
Biochemical Society transactions 2000;28(4):357-62.
2000: Neil J Bulleid; D C John; Karl Kadler
Recombinant expression systems for the production of collagen.
Biochemical Society transactions 2000;28(4):350-3.
2000: Roger S Meadows; David F Holmes; CJ Gilpin; Karl Kadler
Electron cryomicroscopy of fibrillar collagens.
Methods in molecular biology (Clifton, N.J.) 2000;139():95-109.
1999: D C John; R Watson; Alex J Kind; A R Scott; Karl Kadler; Neil J Bulleid
Expression of an engineered form of recombinant procollagen in mouse milk.
Nature biotechnology 1999;17(4):385-9.
1999: D S Marks; C A Gregory; G A Wallis; Andrew Brass; Karl Kadler; Raymond P Boot-Handford
Metaphyseal chondrodysplasia type Schmid mutations are predicted to occur in two distinct three-dimensional clusters within type X collagen NC1 domains that retain the ability to trimerize.
The Journal of biological chemistry 1999;274(6):3632-41.
1998: John A Trotter; J A Chapman; Karl Kadler; David F Holmes
Growth of sea cucumber collagen fibrils occurs at the tips and centers in a coordinated manner.
Journal of molecular biology 1998;284(5):1417-24.
1998: David F Holmes; HK Graham; Karl Kadler
Collagen fibrils forming in developing tendon show an early and abrupt limitation in diameter at the growing tips.
Journal of molecular biology 1998;283(5):1049-58.
1998: S P Douglas; Karl Kadler
Specific glycanforms of type IX collagen accumulate in embryonic chick sterna after 17 days of development.
Glycobiology 1998;8(10):1013-9.
1998: Rod B Watson; David F Holmes; HK Graham; B V Nusgens; Karl Kadler
Surface located procollagen N-propeptides on dermatosparactic collagen fibrils are not cleaved by procollagen N-proteinase and do not inhibit binding of decorin to the fibril surface.
Journal of molecular biology 1998;278(1):195-204.
1998: S P Douglas; J M Jenkins; Karl Kadler
Collagen IX: evidence for a structural association between NC4 domains in cartilage and a novel cleavage site in the alpha 1(IX) chain.
Matrix biology : journal of the International Society for Matrix Biology 1998;16(8):497-505.
1997: Keith G Danielson; H Baribault; David F Holmes; H Graham; Karl Kadler; Renato V Iozzo
Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility.
The Journal of cell biology 1997;136(3):729-43.
1996: I C Scott; R Halila; J M Jenkins; S Mehan; S Apostolou; R Winqvist; D F Callen; D J Prockop; L Peltonen; Karl Kadler
Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1).
Gene 1996;174(1):135-43.
1996: David F Holmes; R B Watson; J A Chapman; Karl Kadler
Enzymic control of collagen fibril shape.
Journal of molecular biology 1996;261(2):93-7.
1996: Andrzej Fertala; David F Holmes; Karl Kadler; Aleksander L Sieron; Darwin J Prockop
Assembly in vitro of thin and thick fibrils of collagen II from recombinant procollagen II. The monomers in the tips of thick fibrils have the opposite orientation from monomers in the growing tips of collagen I fibrils.
The Journal of biological chemistry 1996;271(25):14864-9.
1996: Karl Kadler; David F Holmes; John A Trotter; J A Chapman
Collagen fibril formation.
The Biochemical journal 1996;316 ( Pt 1)():1-11.
1996: A A Culbert; G A Wallis; Karl Kadler
Tracing the pathway between mutation and phenotype in osteogenesis imperfecta: isolation of mineralization-specific genes.
American journal of medical genetics 1996;63(1):167-74.
1995: A A Culbert; M P Lowe; M Atkinson; Peter H Byers; G A Wallis; Karl Kadler
Substitutions of aspartic acid for glycine-220 and of arginine for glycine-664 in the triple helix of the pro alpha 1(I) chain of type I procollagen produce lethal osteogenesis imperfecta and disrupt the ability of collagen fibrils to incorporate crystalline hydroxyapatite.
The Biochemical journal 1995;311 ( Pt 3)():815-20.
1995: John Parkinson; Karl Kadler; Andrew Brass
Simple physical model of collagen fibrillogenesis based on diffusion limited aggregation.
Journal of molecular biology 1995;247(4):823-31.
1995: Karl Kadler; R B Watson
Procollagen C-peptidase: procollagen C-proteinase.
Methods in enzymology 1995;248():771-81.
1995: Karl Kadler; S J Lightfoot; R B Watson
Procollagen N-peptidases: procollagen N-proteinases.
Methods in enzymology 1995;248():756-71.
1995: Karl Kadler
Extracellular matrix 1: Fibril-forming collagens.
Protein profile 1995;2(5):491-619.
1994: S J Lightfoot; M S Atkinson; G Murphy; Peter H Byers; Karl Kadler
Substitution of serine for glycine 883 in the triple helix of the pro alpha 1 (I) chain of type I procollagen produces osteogenesis imperfecta type IV and introduces a structural change in the triple helix that does not alter cleavage of the molecule by procollagen N-proteinase.
The Journal of biological chemistry 1994;269(48):30352-7.
1994: Karl Kadler
Extracellular matrix. 1: fibril-forming collagens.
Protein profile 1994;1(5):519-638.
1993: Karl Kadler
Learning how mutations in type I collagen genes cause connective tissue disease.
International journal of experimental pathology 1993;74(4):319-23.
1993: David F Holmes; R B Watson; B Steinmann; Karl Kadler
Ehlers-Danlos syndrome type VIIB. Morphology of type I collagen fibrils formed in vivo and in vitro is determined by the conformation of the retained N-propeptide.
The Journal of biological chemistry 1993;268(21):15758-65.
1992: G A Wallis; Karl Kadler; B J Starman; Peter H Byers
A tripeptide deletion in the triple-helical domain of the pro alpha 1(I) chain of type I procollagen in a patient with lethal osteogenesis imperfecta does not alter cleavage of the molecule by N-proteinase.
The Journal of biological chemistry 1992;267(35):25529-34.
1992: S J Lightfoot; David F Holmes; Andrew Brass; Michael E Grant; Peter H Byers; Karl Kadler
Type I procollagens containing substitutions of aspartate, arginine, and cysteine for glycine in the pro alpha 1 (I) chain are cleaved slowly by N-proteinase, but only the cysteine substitution introduces a kink in the molecule.
The Journal of biological chemistry 1992;267(35):25521-8.
1992: David F Holmes; J A Chapman; D J Prockop; Karl Kadler
Growing tips of type I collagen fibrils formed in vitro are near-paraboloidal in shape, implying a reciprocal relationship between accretion and diameter.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9855-9.
1992: D J McBride; Karl Kadler; Y Hojima; Darwin J Prockop
Self-assembly into fibrils of a homotrimer of type I collagen.
Matrix (Stuttgart, Germany) 1992;12(4):256-63.
1992: Andrew Brass; Karl Kadler; J T Thomas; Michael E Grant; Raymond P Boot-Handford
The fibrillar collagens, collagen VIII, collagen X and the C1q complement proteins share a similar domain in their C-terminal non-collagenous regions.
FEBS letters 1992;303(2-3):126-8.
1992: R B Watson; G A Wallis; David F Holmes; D Viljoen; Peter H Byers; Karl Kadler
Ehlers Danlos syndrome type VIIB. Incomplete cleavage of abnormal type I procollagen by N-proteinase in vitro results in the formation of copolymers of collagen and partially cleaved pNcollagen that are near circular in cross-section.
The Journal of biological chemistry 1992;267(13):9093-100.
1992: Y Hojima; J McKenzie; Karl Kadler; D J McBride; Michel van der Rest; M M Mörgelin; J Engel; Darwin J Prockop
A new 500-kDa form of type I procollagen N-proteinase from chick embryo tendons.
Matrix (Stuttgart, Germany). Supplement 1992;1():97-8.
1991: David F Holmes; R B Watson; Karl Kadler
On the regulation of collagen-fibril shape and form.
Biochemical Society transactions 1991;19(4):808-11.
1991: Andrew Brass; Karl Kadler; J T Thomas; Michael E Grant; Raymond P Boot-Handford
The aromatic zipper: a model for the initial trimerization event in collagen folding.
Biochemical Society transactions 1991;19(4):365S.
1991: A M Romanic; E Adachi; Karl Kadler; Y Hojima; Darwin J Prockop
Copolymerization of pNcollagen III and collagen I. pNcollagen III decreases the rate of incorporation of collagen I into fibrils, the amount of collagen I incorporated, and the diameter of the fibrils formed.
The Journal of biological chemistry 1991;266(19):12703-9.
1991: Karl Kadler; A Torre-Blanco; E Adachi; B E Vogel; Y Hojima; Darwin J Prockop
A type I collagen with substitution of a cysteine for glycine-748 in the alpha 1(I) chain copolymerizes with normal type I collagen and can generate fractallike structures.
Biochemistry 1991;30(20):5081-8.
1990: Karl Kadler; Y Hojima; Darwin J Prockop
Collagen fibrils in vitro grow from pointed tips in the C- to N-terminal direction.
The Biochemical journal 1990;268(2):339-43.
1990: Karl Kadler; David Hulmes; Y Hojima; Darwin J Prockop
Assembly of type I collagen fibrils de novo by the specific enzymic cleavage of pC collagen. The fibrils formed at about 37 degrees C are similar in diameter, roundness, and apparent flexibility to the collagen fibrils seen in connective tissue.
Annals of the New York Academy of Sciences 1990;580():214-24.
1990: J A Chapman; M Tzaphlidou; K M Meek; Karl Kadler
The collagen fibril--a model system for studying the staining and fixation of a protein.
Electron microscopy reviews 1990;3(1):143-82.
1989: David Hulmes; Karl Kadler; Paul Mould; Y Hojima; David F Holmes; C Cummings; J A Chapman; D J Prockop
Pleomorphism in type I collagen fibrils produced by persistence of the procollagen N-propeptide.
Journal of molecular biology 1989;210(2):337-45.
1989: Darwin J Prockop; C D Constantinou; K E Dombrowski; Y Hojima; Karl Kadler; Helena Kuivaniemi; Gerard Tromp; B E Vogel
Type I procollagen: the gene-protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissue.
American journal of medical genetics 1989;34(1):60-7.
1988: B E Vogel; R Doelz; Karl Kadler; Y Hojima; J Engel; Darwin J Prockop
A substitution of cysteine for glycine 748 of the alpha 1 chain produces a kink at this site in the procollagen I molecule and an altered N-proteinase cleavage site over 225 nm away.
The Journal of biological chemistry 1988;263(35):19249-55.
1988: Karl Kadler; Y Hojima; Darwin J Prockop
Assembly of type I collagen fibrils de novo. Between 37 and 41 degrees C the process is limited by micro-unfolding of monomers.
The Journal of biological chemistry 1988;263(21):10517-23.
1988: Darwin J Prockop; Karl Kadler; Y Hojima; C D Constantinou; K E Dombrowski; Helena Kuivaniemi; Gerard Tromp; B Vogel
Expression of type I procollagen genes.
Ciba Foundation symposium 1988;136():142-60.
1987: Karl Kadler; Y Hojima; Darwin J Prockop
Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process.
The Journal of biological chemistry 1987;262(32):15696-701.
1987: Karl Kadler; D J Prockop
Protein structure and the specific heat of water.
Nature 1987;325(6103):395.
1985: Paul Mould; David F Holmes; Karl Kadler; J A Chapman
Mica sandwich technique for preparing macromolecules for rotary shadowing.
Journal of ultrastructure research 1985;91(1):66-76.
1981: Karl Kadler; J S Moore
Radiolytic destruction of the transition-metal-binding site in concanavalin A.
International journal of radiation biology and related studies in physics, chemistry, and medicine 1981;39(6):677-81.