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William Carroll

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Derek W Nelson; Madhavi Pai; Keith Ryther; Karin R Tietje; Betty Yao; Chang Zhu; William A Carroll; Prasant Chandran; Michael J Dart; Anthony V Daza; Odile F El-Kouhen; Yihong Fan; Alan S Florjancic; Jennifer M Frost; Tiffany R Garrison; George Grayson; Bradley A Hooker; Gin C Hsieh; Michael D Meyer
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management.
Arturo Perez-Medrano; Diana L Donnelly-Roberts; Alan S Florjancic; Derek W Nelson; Tongmei Li; Marian T Namovic; Sridhar Peddi; Connie R Faltynek; Michael F Jarvis; William A Carroll
Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists.
Gin C Hsieh; Madhavi Pai; Prasant Chandran; Bradley A Hooker; Chang Z Zhu; Anita K Salyers; Erica J Wensink; CenChen Zhan; William A Carroll; Michael J Dart; Betty B Yao; Prisca Honore; Michael D Meyer
Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats.

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All Publications

2012: Derek W Nelson; Madhavi Pai; Keith Ryther; Karin R Tietje; Betty Yao; Chang Zhu; William A Carroll; Prasant Chandran; Michael J Dart; Anthony V Daza; Odile F El-Kouhen; Yihong Fan; Alan S Florjancic; Jennifer M Frost; Tiffany R Garrison; George Grayson; Bradley A Hooker; Gin C Hsieh; Michael D Meyer
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management.
Bioorganic & medicinal chemistry letters 2012;22(7):2604-8.
2011: Arturo Perez-Medrano; Diana L Donnelly-Roberts; Alan S Florjancic; Derek W Nelson; Tongmei Li; Marian T Namovic; Sridhar Peddi; Connie R Faltynek; Michael F Jarvis; William A Carroll
Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists.
Bioorganic & medicinal chemistry letters 2011;21(11):3297-300.
2011: Gin C Hsieh; Madhavi Pai; Prasant Chandran; Bradley A Hooker; Chang Z Zhu; Anita K Salyers; Erica J Wensink; CenChen Zhan; William A Carroll; Michael J Dart; Betty B Yao; Prisca Honore; Michael D Meyer
Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats.
British journal of pharmacology 2011;162(2):428-40.
2009: Arturo Perez-Medrano; Diana L Donnelly-Roberts; Prisca Honore; Gin C Hsieh; Marian T Namovic; Sridhar Peddi; Qi Shuai; Ying Wang; Connie R Faltynek; Michael F Jarvis; William A Carroll
Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.
Journal of medicinal chemistry 2009;52(10):3366-76.
2009: William A Carroll; Diana L Donnelly-Roberts; Michael F Jarvis
Selective P2X(7) receptor antagonists for chronic inflammation and pain.
Purinergic signalling 2009;5(1):63-73.
2009: Diana L Donnelly-Roberts; Marian T Namovic; Bruce W Surber; Srirajan X Vaidyanathan; Arturo Perez-Medrano; Ying Wang; William A Carroll; Michael F Jarvis
[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors.
Neuropharmacology 2009;56(1):223-9.
2008: Irene Drizin; Robert J Gregg; Marc J C Scanio; Lei Shi; Michael F Gross; Robert N Atkinson; James B Thomas; Matthew S Johnson; William A Carroll; Brian E Marron; Mark L Chapman; Dong Liu; Michael J Krambis; Char-Chang Shieh; XuFeng Zhang; Gricelda Hernandez; Donna M Gauvin; Joe Mikusa; Chang Z Zhu; Shailen Joshi; Prisca Honore; Kennan Marsh; Rosemarie Roeloffs; Stephen Werness; Douglas S Krafte; Michael F Jarvis; Connie R Faltynek; Michael E Kort
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.
Bioorganic & medicinal chemistry 2008;16(12):6379-86.
2008: Derek W Nelson; Kathy A Sarris; Douglas Kalvin; Marian T Namovic; George Grayson; Diana L Donnelly-Roberts; Richard Harris; Prisca Honore; Michael F Jarvis; Connie R Faltynek; William A Carroll
Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists.
Journal of medicinal chemistry 2008;51(10):3030-4.
2008: Alan S Florjancic; Sridhar Peddi; Arturo Perez-Medrano; Biqin Li; Marian T Namovic; George Grayson; Diana L Donnelly-Roberts; Michael F Jarvis; William A Carroll
Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists.
Bioorganic & medicinal chemistry letters 2008;18(6):2089-92.
2008: Michael E Kort; Irene Drizin; Robert J Gregg; Marc J C Scanio; Lei Shi; Michael F Gross; Robert N Atkinson; Matthew S Johnson; Gregory J Pacofsky; James B Thomas; William A Carroll; Michael J Krambis; Dong Liu; Char-Chang Shieh; Xufeng Zhang; Gricelda Hernandez; Joe Mikusa; Chengmin Zhong; Shailen Joshi; Prisca Honore; Rosemarie Roeloffs; Kennan Marsh; Bernard P Murray; Jinrong Liu; Stephen Werness; Connie R Faltynek; Douglas S Krafte; Michael F Jarvis; Mark L Chapman; Brian E Marron
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
Journal of medicinal chemistry 2008;51(3):407-16.
2007: Arturo Perez-Medrano; Michael E Brune; Steven A Buckner; Michael J Coghlan; Thomas A Fey; Murali Gopalakrishnan; Robert J Gregg; Michael E Kort; Victoria E Scott; James P Sullivan; Kristi Whiteaker; William A Carroll
Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.
Journal of medicinal chemistry 2007;50(24):6265-73.
2007: William A Carroll; Douglas Kalvin; Arturo Perez-Medrano; Alan S Florjancic; Ying Wang; Diana L Donnelly-Roberts; Marian T Namovic; George Grayson; Prisca Honoré; Michael F Jarvis
Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists.
Bioorganic & medicinal chemistry letters 2007;17(14):4044-8.
2007: Steve McGaraughty; Katharine L Chu; Marian T Namovic; Diana L Donnelly-Roberts; Richard R Harris; Xu-Feng Zhang; Char-Chang Shieh; Carol T Wismer; Chang Z Zhu; Donna M Gauvin; Adebola Fabiyi; Prisca Honore; Robert J Gregg; Michael E Kort; D W Nelson; William A Carroll; Kennan Marsh; Connie R Faltynek; Michael F Jarvis
P2X7-related modulation of pathological nociception in rats.
Neuroscience 2007;146(4):1817-28.
2007: Char-Chang Shieh; Michael E Brune; Steven A Buckner; Kristi Whiteaker; Eduardo J Molinari; Ivan Milicic; Adebola Fabiyi; Anthony V Daza; Jorge D Brioni; William A Carroll; K Matsushita; M Yamada; Y Kurachi; Murali Gopalakrishnan
Characterization of a novel ATP-sensitive K+ channel opener, A-251179, on urinary bladder relaxation and cystometric parameters.
British journal of pharmacology 2007;151(4):467-75.
2006: Robert J Altenbach; Michael E Brune; Steven A Buckner; Michael J Coghlan; Anthony V Daza; Adebola Fabiyi; Murali Gopalakrishnan; Rodger F Henry; Albert Khilevich; Michael E Kort; Ivan Milicic; Victoria E Scott; Jamie C Smith; Kristi Whiteaker; William A Carroll
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
Journal of medicinal chemistry 2006;49(23):6869-87.
2006: Derek W Nelson; Robert J Gregg; Michael E Kort; Arturo Perez-Medrano; Eric A Voight; Ying Wang; George Grayson; Marian T Namovic; Diana L Donnelly-Roberts; Wende Niforatos; Prisca Honore; Michael F Jarvis; Connie R Faltynek; William A Carroll
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.
Journal of medicinal chemistry 2006;49(12):3659-66.
2005: Ryan M Fryer; Pamela A Rakestraw; Lee C Preusser; Michael E Brune; William A Carroll; Steven A Buckner; Char-Chang Shieh; Linda L King; Kennan Marsh; Murali Gopalakrishnan; Bryan Cox; Glenn A Reinhart
Pharmacological characterization of the novel dihydropyridine potassium channel opener, (9R)-9-(3-iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione (A-325100), and the regulation of cardiovascular function in conscious and anesthetized beagle dogs.
Journal of cardiovascular pharmacology 2005;46(2):232-40.
2004: Murali Gopalakrishnan; Steven A Buckner; Char-Chang Shieh; Thomas A Fey; Adebola Fabiyi; Kristi Whiteaker; Rachel Davis-Taber; Ivan Milicic; Anthony V Daza; Victoria E Scott; Neil A Castle; David Printzenhoff; Brecht London; Sean C Turner; William A Carroll; James P Sullivan; Michael J Coghlan; Michael E Brune
In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.
British journal of pharmacology 2004;143(1):81-90.
2004: William A Carroll; Konstantinos A Agrios; Robert J Altenbach; Steven A Buckner; Yiyuan Chen; Michael J Coghlan; Anthony V Daza; Irene Drizin; Murali Gopalakrishnan; Rodger F Henry; Michael E Kort; Philip R Kym; Ivan Milicic; Jamie C Smith; Rui Tang; Sean C Turner; Kristi Whiteaker; Henry Zhang; James P Sullivan
Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro.
Journal of medicinal chemistry 2004;47(12):3180-92.
2004: William A Carroll; Robert J Altenbach; Hao Bai; Jorge D Brioni; Michael E Brune; Steven A Buckner; Christopher Cassidy; Yiyuan Chen; Michael J Coghlan; Anthony V Daza; Irene Drizin; Thomas A Fey; Michael Fitzgerald; Murali Gopalakrishnan; Robert J Gregg; Rodger F Henry; Mark W Holladay; Linda L King; Michael E Kort; Philip R Kym; Ivan Milicic; Rui Tang; Sean C Turner; Kristi Whiteaker; Lin Yi; Henry Zhang; James P Sullivan
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions.
Journal of medicinal chemistry 2004;47(12):3163-79.
2004: Irene Drizin; Robert J Altenbach; Steven A Buckner; Kristi Whiteaker; Victoria E Scott; John F Darbyshire; Venkata K Jayanti; Rodger F Henry; Michael J Coghlan; Murali Gopalakrishnan; William A Carroll
Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K(ATP) channel openers.
Bioorganic & medicinal chemistry 2004;12(8):1895-904.
2004: Holger Felsch; Ulf Lange; Annette Hambrock; Cornelia Löffler-Walz; Ulrich Russ; William A Carroll; Murali Gopalakrishnan; Ulrich Quast
Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075.
British journal of pharmacology 2004;141(7):1098-105.
2004: Arturo Perez-Medrano; Steven A Buckner; Michael J Coghlan; Robert J Gregg; Murali Gopalakrishnan; Michael E Kort; John K Lynch; Victoria E Scott; James P Sullivan; Kristi Whiteaker; William A Carroll
Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.
Bioorganic & medicinal chemistry letters 2004;14(2):397-400.
2003: Rachel Davis-Taber; Eduardo J Molinari; Robert J Altenbach; Kristi Whiteaker; Char-Chang Shieh; Gary Rotert; Steven A Buckner; John Malysz; Ivan Milicic; Jeffrey S McDermott; Gary Gintant; Michael J Coghlan; William A Carroll; Victoria E Scott; Murali Gopalakrishnan
[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.
Molecular pharmacology 2003;64(1):143-53.
2003: Sean C Turner; William A Carroll; Tammie K White; Murali Gopalakrishnan; Michael J Coghlan; Char-Chang Shieh; Xu-Feng Zhang; Ashutosh S Parihar; Steven A Buckner; Ivan Milicic; James P Sullivan
The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles.
Bioorganic & medicinal chemistry letters 2003;13(12):2003-7.
2003: Sean C Turner; William A Carroll; Tammie K White; Michael E Brune; Steven A Buckner; Murali Gopalakrishnan; Adebola Fabiyi; Michael J Coghlan; Victoria E Scott; Neil A Castle; Anthony V Daza; Ivan Milicic; James P Sullivan
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
Bioorganic & medicinal chemistry letters 2003;13(10):1741-4.
2003: Murali Gopalakrishnan; Thomas R Miller; Steven A Buckner; Ivan Milicic; Eduardo J Molinari; Kristi Whiteaker; Rachel Davis-Taber; Victoria E Scott; Christopher Cassidy; James P Sullivan; William A Carroll
Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novelK(ATP) channel inhibitor.
British journal of pharmacology 2003;138(2):393-9.
2002: Michael E Brune; Thomas A Fey; Jorge D Brioni; James P Sullivan; Michael Williams; William A Carroll; Michael J Coghlan; Murali Gopalakrishnan
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. II. in vivo characterization.
The Journal of pharmacology and experimental therapeutics 2002;303(1):387-94.
2002: Murali Gopalakrishnan; Steven A Buckner; Kristi Whiteaker; Char-Chang Shieh; Eduardo J Molinari; Ivan Milicic; Anthony V Daza; Rachel Davis-Taber; Victoria E Scott; Donna J Sellers; Russell Chess-Williams; Christopher Chapple; Yi Liu; Dong Liu; Jorge D Brioni; James P Sullivan; Michael Williams; William A Carroll; Michael J Coghlan
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization.
The Journal of pharmacology and experimental therapeutics 2002;303(1):379-86.
2002: Irene Drizin; Mark W Holladay; Lin Yi; Henry Q Zhang; Sujatha M Gopalakrishnan; Murali Gopalakrishnan; Kristi Whiteaker; Steven A Buckner; James P Sullivan; William A Carroll
Structure-Activity studies for a novel series of tricyclic dihydropyrimidines as K(ATP) channel openers (KCOs).
Bioorganic & medicinal chemistry letters 2002;12(11):1481-4.
2001: Michael D Meyer; Robert J Altenbach; Hao Bai; Fatima Basha; William A Carroll; James Kerwin; SA Lebold; E Lee; John K Pratt; Kevin B Sippy; Karin R Tietje; Michael D Wendt; Michael E Brune; Steven A Buckner; Arthur A Hancock; Irene Drizin
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.
Journal of medicinal chemistry 2001;44(12):1971-85.
2001: Michael J Coghlan; William A Carroll; Murali Gopalakrishnan
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Journal of medicinal chemistry 2001;44(11):1627-53.
2001: William A Carroll; Kevin B Sippy; Timothy A Esbenshade; Steven A Buckner; Arthur A Hancock; Michael D Meyer
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.
Bioorganic & medicinal chemistry letters 2001;11(9):1119-21.
2000: Michael D Meyer; Robert J Altenbach; Fatima Basha; William A Carroll; S Condon; Steven W Elmore; James Kerwin; Kevin B Sippy; Karin R Tietje; Michael D Wendt; Arthur A Hancock; Michael E Brune; Steven A Buckner; Irene Drizin
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Journal of medicinal chemistry 2000;43(8):1586-603.
1997: Michael D Meyer; Robert J Altenbach; Fatima Basha; William A Carroll; Irene Drizin; Steven W Elmore; P P Ehrlich; SA Lebold; Karin R Tietje; Kevin B Sippy; Michael D Wendt; D J Plata; F Plagge; Steven A Buckner; Michael E Brune; Arthur A Hancock; James Kerwin
Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia.
Journal of medicinal chemistry 1997;40(20):3141-3.
1997: Michael D Meyer; Arthur A Hancock; Karin R Tietje; Kevin B Sippy; R Prasad; D M Stout; D L Arendsen; B G Donner; William A Carroll
Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT uptake inhibiting and alpha2-antagonistic activities.
Journal of medicinal chemistry 1997;40(7):1049-62.