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Barbara Guerra

Research Profile

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Publications

TOP 3
Jennifer Raaf; Markus Pietsch; Bertan Bopp; Barbara Guerra; Olaf-Georg Issinger; Joachim Jose; Ines Neundorf; Karsten Niefind
First Structure of Protein Kinase CK2 Catalytic Subunit with an Effective CK2β-Competitive Ligand.
Birgitte B Olsen; Tina H Svenstrup; Barbara Guerra
Downregulation of protein kinase CK2 induces autophagic cell death through modulation of the mTOR and MAPK signaling pathways in human glioblastoma cells.
Christina Westmose Yde; Kristina B Emdal; Barbara Guerra; Anne E Lykkesfeldt
NFκB signaling is important for growth of antiestrogen resistant breast cancer cells.

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All Publications

2013: Jennifer Raaf; Markus Pietsch; Bertan Bopp; Barbara Guerra; Olaf-Georg Issinger; Joachim Jose; Ines Neundorf; Karsten Niefind
First Structure of Protein Kinase CK2 Catalytic Subunit with an Effective CK2β-Competitive Ligand.
ACS chemical biology 2013;8(5):901-7.
2012: Birgitte B Olsen; Tina H Svenstrup; Barbara Guerra
Downregulation of protein kinase CK2 induces autophagic cell death through modulation of the mTOR and MAPK signaling pathways in human glioblastoma cells.
International journal of oncology 2012;41(6):1967-76.
2012: Christina Westmose Yde; Kristina B Emdal; Barbara Guerra; Anne E Lykkesfeldt
NFκB signaling is important for growth of antiestrogen resistant breast cancer cells.
Breast cancer research and treatment 2012;135(1):67-78.
2012: Jan N Kreutzer; David W Litchfield; Alessia Salvador; Daniela Vedaldi; Girolamo Cirrincione; Patrizia Diana; Olaf-Georg Issinger; Barbara Guerra
2-Triazenoazaindoles: α novel class of triazenes inducing transcriptional down-regulation of EGFR and HER-2 in human pancreatic cancer cells.
International journal of oncology 2012;40(4):914-22.
2012: Birgitte B Olsen; Tina H Svenstrup; Shih-Ya Wang; Benjamin P C Chen; Barbara Guerra
Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage.
BMC molecular biology 2012;13():7.
2011: Jan Kreutzer; Karolina Lech; Birgitte B Olsen; Olaf-Georg Issinger; Barbara Guerra
Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity.
Molecular and cellular biochemistry 2011;356(1-2):149-58.
2010: Birgitte B Olsen; Olaf-Georg Issinger; Barbara Guerra
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells.
Oncogene 2010;29(45):6016-26.
2010: Birgitte B Olsen; Jan Kreutzer; Nobumoto Watanabe; Tina Holm; Barbara Guerra
Mapping of the interaction sites between Wee1 kinase and the regulatory beta-subunit of protein kinase CK2.
International journal of oncology 2010;36(5):1175-82.
2010: Birgitte B Olsen; Barbara Guerra; Karsten Niefind; Olaf-Georg Issinger
Structural basis of the constitutive activity of protein kinase CK2.
Methods in enzymology 2010;484():515-29.
2010: Jan Kreutzer; Maria Ruzzene; Barbara Guerra
Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells.
BMC cancer 2010;10():440.
2009: Christina Westmose Yde; Mathias P Clausen; Martin V Bennetzen; Anne E Lykkesfeldt; Ole G Mouritsen; Barbara Guerra
The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells.
Anti-cancer drugs 2009;20(8):723-35.
2009: Iben Skjøth Sandholt; Birgitte B Olsen; Barbara Guerra; Olaf-Georg Issinger
Resorufin: a lead for a new protein kinase CK2 inhibitor.
Anti-cancer drugs 2009;20(4):238-48.
2008: Birgitte B Olsen; Barbara Guerra
Ability of CK2beta to selectively regulate cellular protein kinases.
Molecular and cellular biochemistry 2008;316(1-2):115-26.
2008: Christina Westmose Yde; Birgitte B Olsen; David W Meek; Norinobu M Watanabe; Barbara Guerra
The regulatory beta-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis.
Oncogene 2008;27(37):4986-97.
2008: Barbara Guerra; Olaf-Georg Issinger
Protein kinase CK2 in human diseases.
Current medicinal chemistry 2008;15(19):1870-86.
2007: Jan Kreutzer; Barbara Guerra
The regulatory beta-subunit of protein kinase CK2 accelerates the degradation of CDC25A phosphatase through the checkpoint kinase Chk1.
International journal of oncology 2007;31(5):1251-9.
2007: Birgitte B Olsen; Marina Bjørling-Poulsen; Barbara Guerra
Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action.
The international journal of biochemistry & cell biology 2007;39(1):227-37.
2006: Barbara Guerra
Protein kinase CK2 subunits are positive regulators of AKT kinase.
International journal of oncology 2006;28(3):685-93.
2004: Lars P Kristensen; Martin R Larsen; Peter Højrup; Olaf-Georg Issinger; Barbara Guerra
Phosphorylation of the regulatory beta-subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2beta phosphorylation site.
FEBS letters 2004;569(1-3):217-23.
2003: Marina Bjørling-Poulsen; Gerhard Seitz; Barbara Guerra; Olaf-Georg Issinger
The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas.
International journal of oncology 2003;23(4):1015-23.
2001: Barbara Guerra; Brigitte Boldyreff; Olaf-Georg Issinger
FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction.
International journal of oncology 2001;19(6):1117-26.
2001: Barbara Guerra; Karsten Niefind; I Ermakowa; Olaf-Georg Issinger
Characterization of CK2 holoenzyme variants with regard to crystallization.
Molecular and cellular biochemistry 2001;227(1-2):3-11.
2001: Karsten Niefind; Barbara Guerra; I Ermakowa; Olaf-Georg Issinger
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
The EMBO journal 2001;20(19):5320-31.
2001: Hans H Jensen; Majbrit Hjerrild; Barbara Guerra; Martin R Larsen; Peter Højrup; Brigitte Boldyreff
Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites.
The international journal of biochemistry & cell biology 2001;33(6):577-89.
2000: Karsten Niefind; Barbara Guerra; I Ermakowa; Olaf-Georg Issinger
Crystallization and preliminary characterization of crystals of human protein kinase CK2.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 12):1680-4.
1999: Barbara Guerra; S Siemer; Brigitte Boldyreff; Olaf-Georg Issinger
Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles.
FEBS letters 1999;462(3):353-7.
1999: Karsten Niefind; M Pütter; Barbara Guerra; Olaf-Georg Issinger; Dietmar Schomburg
GTP plus water mimic ATP in the active site of protein kinase CK2.
Nature structural biology 1999;6(12):1100-3.
1999: S Siemer; D Ornskov; Barbara Guerra; Brigitte Boldyreff; Olaf-Georg Issinger
Determination of mRNA, and protein levels of p53, MDM2 and protein kinase CK2 subunits in F9 cells after treatment with the apoptosis-inducing drugs cisplatin and carboplatin.
The international journal of biochemistry & cell biology 1999;31(6):661-70.
1999: Barbara Guerra; Brigitte Boldyreff; Stefania Sarno; Luca Cesaro; Olaf-Georg Issinger; Lorenzo A Pinna
CK2: a protein kinase in need of control.
Pharmacology & therapeutics 1999;82(2-3):303-13.
1999: Barbara Guerra; Olaf-Georg Issinger
Protein kinase CK2 and its role in cellular proliferation, development and pathology.
Electrophoresis 1999;20(2):391-408.
1998: Karsten Niefind; Barbara Guerra; L A Pinna; Olaf-Georg Issinger; Dietmar Schomburg
Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.
The EMBO journal 1998;17(9):2451-62.