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Austin Hughes

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T-Lymphocytes, Cytotoxic

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TOP 3
Austin Hughes
Evolution of adaptive phenotypic traits without positive Darwinian selection.
Benoît Callendret; Heather B Eccleston; Dana L Hasselschwert; Ryan Heksch; Austin Hughes; Robert H Purcell; Jens Bukh; Christopher M Walker
Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8⁺ T cells in early viral evolution.
Austin Hughes; Federica Verra
Malaria parasite sequences from chimpanzee support the co-speciation hypothesis for the origin of virulent human malaria (Plasmodium falciparum).

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All Publications

2012: Austin Hughes
Evolution of adaptive phenotypic traits without positive Darwinian selection.
Heredity 2012;108(4):347-53.
2011: Benoît Callendret; Heather B Eccleston; Dana L Hasselschwert; Ryan Heksch; Austin Hughes; Robert H Purcell; Jens Bukh; Christopher M Walker
Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8⁺ T cells in early viral evolution.
Journal of virology 2011;85(22):11833-45.
2010: Austin Hughes; Federica Verra
Malaria parasite sequences from chimpanzee support the co-speciation hypothesis for the origin of virulent human malaria (Plasmodium falciparum).
Molecular phylogenetics and evolution 2010;57(1):135-43.
2010: Austin Hughes; A J Buitenhuis
Reduced variance of gene expression at numerous loci in a population of chickens selected for high feather pecking.
Poultry science 2010;89(9):1858-69.
2010: Somchai Jongwutiwes; Chaturong Putaporntip; Austin Hughes
Bottleneck effects on vaccine-candidate antigen diversity of malaria parasites in Thailand.
Vaccine 2010;28(18):3112-7.
2010: Shelby L O'Connor; Jennifer J Lhost; Ericka A Becker; Ann M Detmer; Randall C Johnson; Caitlin E Macnair; Roger W Wiseman; Julie A Karl; Justin M Greene; Benjamin J Burwitz; Benjamin N Bimber; Simon M Lank; Jennifer J Tuscher; Edward T Mee; Nicola J Rose; Ronald C Desrosiers; Austin Hughes; Thomas C Friedrich; Mary Carrington; David O'Connor
MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques.
Science translational medicine 2010;2(22):22ra18.
2010: Michael J Fuller; Naglaa H Shoukry; Toshifumi Gushima; David G Bowen; Benoit Callendret; Katherine J Campbell; Dana L Hasselschwert; Austin Hughes; Christopher M Walker
Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2010;51(2):378-87.
2010: Stephanie Jiménez Irausquin; Austin Hughes
Conflicting selection pressures target the NS3 protein in hepatitis C virus genotypes 1a and 1b.
Virus research 2010;147(2):202-7.
2010: Austin Hughes; Stephanie Irausquin; Robert Friedman
The evolutionary biology of poxviruses.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2010;10(1):50-9.
2009: Chaturong Putaporntip; Somchai Jongwutiwes; Priscila Grynberg; Liwang Cui; Austin Hughes
Nucleotide sequence polymorphism at the apical membrane antigen-1 locus reveals population history of Plasmodium vivax in Thailand.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2009;9(6):1295-300.
2009: Austin Hughes
Small effective population sizes and rare nonsynonymous variants in potyviruses.
Virology 2009;393(1):127-34.
2009: Austin Hughes
Relaxation of purifying selection on the SAD lineage of live attenuated oral vaccines for rabies virus.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2009;9(5):827-31.
2009: Benjamin N Bimber; Benjamin J Burwitz; Shelby O'Connor; Ann Detmer; Emma Gostick; Simon M Lank; David A Price; Austin Hughes; David O'Connor
Ultradeep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in simian immunodeficiency virus-infected macaques.
Journal of virology 2009;83(16):8247-53.
2009: Austin Hughes; Robert Friedman
A phylogenetic approach to gene expression data: evidence for the evolutionary origin of mammalian leukocyte phenotypes.
Evolution & development 2009;11(4):382-90.
2009: Chaturong Putaporntip; Somchai Jongwutiwes; Austin Hughes
Natural selection maintains a stable polymorphism at the circumsporozoite protein locus of Plasmodium falciparum in a low endemic area.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2009;9(4):567-73.
2009: Austin Hughes; Robert Friedman
More radical amino acid replacements in primates than in rodents: support for the evolutionary role of effective population size.
Gene 2009;440(1-2):50-6.
2009: Gennadiy I Bondarenko; Svetlana V Dambaeva; Richard L Grendell; Austin Hughes; Maureen Durning; Mark A Garthwaite; Thaddeus G Golos
Characterization of cynomolgus and vervet monkey placental MHC class I expression: diversity of the nonhuman primate AG locus.
Immunogenetics 2009;61(6):431-42.
2009: Alan J Conley; C Jo Corbin; Austin Hughes
Adaptive evolution of mammalian aromatases: lessons from Suiformes.
Journal of experimental zoology. Part A, Ecological genetics and physiology 2009;311(5):346-57.
2009: Austin Hughes
Relaxation of purifying selection on live attenuated vaccine strains of the family Paramyxoviridae.
Vaccine 2009;27(11):1685-90.
2009: Kevin J Campbell; Ann M Detmer; Julie A Karl; Roger W Wiseman; Alex J Blasky; Austin Hughes; Benjamin N Bimber; Shelby L O'Connor; David O'Connor
Characterization of 47 MHC class I sequences in Filipino cynomolgus macaques.
Immunogenetics 2009;61(3):177-87.
2009: Austin Hughes
Evolution in the post-genome era.
Perspectives in biology and medicine 2009;52(2):332-7.
2008: Chaturong Putaporntip; Somchai Jongwutiwes; Austin Hughes
Differential selective pressures on the merozoite surface protein 2 locus of Plasmodium falciparum in a low endemic area.
Gene 2008;427(1-2):51-7.
2008: Austin Hughes; Robert Friedman
Genome size reduction in the chicken has involved massive loss of ancestral protein-coding genes.
Molecular biology and evolution 2008;25(12):2681-8.
2008: Benjamin N Bimber; Anna J Moreland; Roger W Wiseman; Austin Hughes; David O'Connor
Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6301-8.
2008: Austin Hughes; Robert Friedman; Pierre Rivailler; Jeffrey O French
Synonymous and nonsynonymous polymorphisms versus divergences in bacterial genomes.
Molecular biology and evolution 2008;25(10):2199-209.
2008: Austin Hughes; Robert Friedman
Alternative splicing, gene duplication and connectivity in the genetic interaction network of the nematode worm Caenorhabditis elegans.
Genetica 2008;134(2):181-6.
2008: Austin Hughes
The origin of adaptive phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13193-4.
2008: Austin Hughes; Robert Friedman
Codon-based tests of positive selection, branch lengths, and the evolution of mammalian immune system genes.
Immunogenetics 2008;60(9):495-506.
2008: Stephanie Jiménez Irausquin; Austin Hughes
Distinctive pattern of sequence polymorphism in the NS3 protein of hepatitis C virus type 1b reflects conflicting evolutionary pressures.
The Journal of general virology 2008;89(Pt 8):1921-9.
2008: Chad J Pendley; Ericka A Becker; Julie A Karl; Alex J Blasky; Roger W Wiseman; Austin Hughes; Shelby L O'Connor; David O'Connor
MHC class I characterization of Indonesian cynomolgus macaques.
Immunogenetics 2008;60(7):339-51.
2008: Austin Hughes; Robert Welch; Vinita Puri; Casey Matthews; Kashif Haque; STEPHEN CHANOCK; Meredith Yeager
Genome-wide SNP typing reveals signatures of population history.
Genomics 2008;92(1):1-8.
2008: Nicholas J Maness; Levi J Yant; Chungwon Chung; John T Loffredo; Thomas C Friedrich; Shari M Piaskowski; Jessica Furlott; Gemma E May; Taeko Soma; Enrique J León; Nancy A Wilson; Helen Piontkivska; Austin Hughes; John Sidney; Alessandro Sette; David Ian Watkins
Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.
Journal of virology 2008;82(11):5245-54.
2008: Austin Hughes; Helen Piontkivska
Functional diversification of the toll-like receptor gene family.
Immunogenetics 2008;60(5):249-56.
2008: Austin Hughes; Helen Piontkivska
Nucleotide sequence polymorphism in circoviruses.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2008;8(2):130-8.
2008: Austin Hughes
Near neutrality: leading edge of the neutral theory of molecular evolution.
Annals of the New York Academy of Sciences 2008;1133():162-79.
2008: Priscila Grynberg; Cor Jesus Fernandes Fontes; Austin Hughes; Erika M Braga
Polymorphism at the apical membrane antigen 1 locus reflects the world population history of Plasmodium vivax.
BMC evolutionary biology 2008;8():123.
2008: Julie A Karl; Roger W Wiseman; Kevin J Campbell; Alex J Blasky; Austin Hughes; Betsy M Ferguson; Daniel S Read; David O'Connor
Identification of MHC class I sequences in Chinese-origin rhesus macaques.
Immunogenetics 2008;60(1):37-46.
2007: Austin Hughes; Mary Ann K Hughes
More effective purifying selection on RNA viruses than in DNA viruses.
Gene 2007;404(1-2):117-25.
2007: Austin Hughes; Pierre Rivailler
Phylogeny and recombination history of gallid herpesvirus 2 (Marek's disease virus) genomes.
Virus research 2007;130(1-2):28-33.
2007: Nicholas J Maness; Laura E Valentine; Gemma E May; Jason Reed; Shari M Piaskowski; Taeko Soma; Jessica Furlott; Eva G Rakasz; Thomas C Friedrich; David A Price; Emma Gostick; Austin Hughes; John Sidney; Alessandro Sette; Nancy A Wilson; David Ian Watkins
AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape.
The Journal of experimental medicine 2007;204(11):2505-12.
2007: C Jo Corbin; Austin Hughes; J R Heffelfinger; Trish Berger; Thomas B Waltzek; Janet F Roser; T C Santos; Maria Angelica Miglino; MF Oliveira; F C Braga; Flávio Meirelles; Alan J Conley
Evolution of suiform aromatases: ancestral duplication with conservation of tissue-specific expression in the collared peccary (Pecari tayassu).
Journal of molecular evolution 2007;65(4):403-12.
2007: Austin Hughes
Looking for Darwin in all the wrong places: the misguided quest for positive selection at the nucleotide sequence level.
Heredity 2007;99(4):364-73.
2007: Austin Hughes; Robert Friedman
The effect of branch lengths on phylogeny: an empirical study using highly conserved orthologs from mammalian genomes.
Molecular phylogenetics and evolution 2007;45(1):81-8.
2007: Austin Hughes; Helen Piontkivska; Ivo Foppa
Rapid fixation of a distinctive sequence motif in the 3' noncoding region of the clade of West Nile virus invading North America.
Gene 2007;399(2):152-61.
2007: Austin Hughes
Evolution of the lung surfactant proteins in birds and mammals.
Immunogenetics 2007;59(7):565-72.
2007: Alan J Conley; C Jo Corbin; Patience Browne; Samantha Mapes; Ned J Place; Austin Hughes; Stephen E Glickman
Placental expression and molecular characterization of aromatase cytochrome P450 in the spotted hyena (Crocuta crocuta).
Placenta 2007;28(7):668-75.
2007: Anne Averdam; Heiner Kuhl; Mario Sontag; Tamara Becker; Austin Hughes; Richard Reinhardt; Lutz Walter
Genomics and diversity of the common marmoset monkey NK complex.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7151-61.
2007: Shelby L O'Connor; Alex J Blasky; Chad J Pendley; Ericka A Becker; Roger W Wiseman; Julie A Karl; Austin Hughes; David O'Connor
Comprehensive characterization of MHC class II haplotypes in Mauritian cynomolgus macaques.
Immunogenetics 2007;59(6):449-62.
2007: Austin Hughes
Micro-scale signature of purifying selection in Marburg virus genomes.
Gene 2007;392(1-2):266-72.
2007: Austin Hughes; Mary Ann K Hughes
Coding sequence polymorphism in avian mitochondrial genomes reflects population histories.
Molecular ecology 2007;16(7):1369-76.
2007: Ryan S Schwarz; Linda Hodes-Villamar; Kelly A Fitzpatrick; Matthew G Fain; Austin Hughes; Luis F Cadavid
A gene family of putative immune recognition molecules in the hydroid Hydractinia.
Immunogenetics 2007;59(3):233-46.
2007: Kristi M Westover; Austin Hughes
Evolution of cytotoxic T-lymphocyte epitopes in hepatitis B virus.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2007;7(2):254-62.
2007: Austin Hughes; Katherine J Langley
Nucleotide usage, synonymous substitution pattern, and past recombination in genomes of Streptococcus pyogenes.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2007;7(2):188-96.
2007: Austin Hughes; Robert Friedman
Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae.
Genetica 2007;129(3):301-8.
2007: Austin Hughes; Mary Ann K Hughes; Robert Friedman
Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus.
Virus research 2007;123(2):147-53.
2007: Robert Friedman; Austin Hughes
Likelihood-ratio tests for positive selection of human and mouse duplicate genes reveal nonconservative and anomalous properties of widely used methods.
Molecular phylogenetics and evolution 2007;42(2):388-93.
2007: Austin Hughes; Jeffrey O French
Homologous recombination and the pattern of nucleotide substitution in Ehrlichia ruminantium.
Gene 2007;387(1-2):31-7.
2007: John T Loffredo; Thomas C Friedrich; Enrique J León; Jason J Stephany; Denise S Rodrigues; Sean P Spencer; Alexander T Bean; Dominic Beal; Benjamin J Burwitz; Richard A Rudersdorf; Lyle T Wallace; Shari M Piaskowski; Gemma E May; John Sidney; Emma Gostick; Nancy A Wilson; David A Price; Esper Kallas; Helen Piontkivska; Austin Hughes; Alessandro Sette; David Ian Watkins
CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.
PloS one 2007;2(11):e1152.
2007: Austin Hughes; Mary Ann K Hughes
Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus).
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2007;7(1):110-5.
2006: Austin Hughes
Evolutionary relationships of vertebrate NACHT domain-containing proteins.
Immunogenetics 2006;58(10):785-91.
2006: Austin Hughes; Robert Friedman
Across-tissue expression and evolution of genes controlled by the Aire transcription factor.
Genomics 2006;88(4):462-7.
2006: Anindita Chakrabarty; James A MacLean; Austin Hughes; R Michael Roberts; Jonathan A Green
Rapid evolution of the trophoblast kunitz domain proteins (TKDPs)-a multigene family in ruminant ungulates.
Journal of molecular evolution 2006;63(2):274-82.
2006: Robert Friedman; Austin Hughes
Pattern of gene duplication in the Cotesia congregata Bracovirus.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2006;6(4):315-22.
2006: Igor I Slukvin; Richard L Grendell; D S Rao; Austin Hughes; Thaddeus G Golos
Cloning of rhesus monkey LILRs.
Tissue antigens 2006;67(4):331-7.
2006: Chaturong Putaporntip; Somchai Jongwutiwes; Takuya Iwasaki; Hiroji Kanbara; Austin Hughes
Ancient common ancestry of the merozoite surface protein 1 of Plasmodium vivax as inferred from its homologue in Plasmodium knowlesi.
Molecular and biochemical parasitology 2006;146(1):105-8.
2006: Helen Piontkivska; Austin Hughes
Patterns of sequence evolution at epitopes for host antibodies and cytotoxic T-lymphocytes in human immunodeficiency virus type 1.
Virus research 2006;116(1-2):98-105.
2006: Austin Hughes; Nancy L Glenn
Contrasting patterns of transcript abundance in tumour tissue and cancer cell lines.
Applied bioinformatics 2006;5(4):201-10.
2005: Austin Hughes; Robert Friedman
Gene duplication and the properties of biological networks.
Journal of molecular evolution 2005;61(6):758-64.
2005: Austin Hughes; Bernice Packer; Robert Welch; STEPHEN CHANOCK; Meredith Yeager
High level of functional polymorphism indicates a unique role of natural selection at human immune system loci.
Immunogenetics 2005;57(11):821-7.
2005: Austin Hughes; Helen Piontkivska; Kendall C Krebs; David O'Connor; David Ian Watkins
Within-host evolution of CD8+-TL epitopes encoded by overlapping and non-overlapping reading frames of simian immunodeficiency virus.
Bioinformatics (Oxford, England) 2005;21 Suppl 3():iii39-44.
2005: Austin Hughes
Consistent across-tissue signatures of differential gene expression in Crohn's disease.
Immunogenetics 2005;57(10):709-16.
2005: Helen Piontkivska; Austin Hughes
Environmental kinetoplastid-like 18S rRNA sequences and phylogenetic relationships among Trypanosomatidae: paraphyly of the genus Trypanosoma.
Molecular and biochemical parasitology 2005;144(1):94-9.
2005: Austin Hughes; Mary Ann K Hughes
Patterns of nucleotide difference in overlapping and non-overlapping reading frames of papillomavirus genomes.
Virus research 2005;113(2):81-8.
2005: Kendall C Krebs; ZheYuan Jin; Richard Rudersdorf; Austin Hughes; David O'Connor
Unusually high frequency MHC class I alleles in Mauritian origin cynomolgus macaques.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5230-9.
2005: Austin Hughes; Robert Friedman
Amino acid sequence constraint and gene expression pattern across the life history in the malaria parasite Plasmodium falciparum.
Molecular and biochemical parasitology 2005;142(2):170-6.
2005: Somchai Jongwutiwes; Chaturong Putaporntip; Takuya Iwasaki; Marcelo U Ferreira; Hiroji Kanbara; Austin Hughes
Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax.
Molecular biology and evolution 2005;22(8):1733-9.
2005: Austin Hughes; Bernice Packer; Robert Welch; Andrew W Bergen; STEPHEN CHANOCK; Meredith Yeager
Effects of natural selection on interpopulation divergence at polymorphic sites in human protein-coding Loci.
Genetics 2005;170(3):1181-7.
2005: Austin Hughes
Gene duplication and the origin of novel proteins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(25):8791-2.
2005: Austin Hughes; Robert Friedman
Loss of ancestral genes in the genomic evolution of Ciona intestinalis.
Evolution & development 2005;7(3):196-200.
2005: Austin Hughes; Robert Friedman
Variation in the pattern of synonymous and nonsynonymous difference between two fungal genomes.
Molecular biology and evolution 2005;22(5):1320-4.
2005: Robert Friedman; Austin Hughes
The pattern of nucleotide difference at individual codons among mouse, rat, and human.
Molecular biology and evolution 2005;22(5):1285-9.
2005: Austin Hughes; Vikram Ekollu; Robert Friedman; John R Rose
Gene family content-based phylogeny of prokaryotes: the effect of criteria for inferring homology.
Systematic biology 2005;54(2):268-76.
2005: Austin Hughes; Robert Friedman
Nucleotide substitution and recombination at orthologous loci in Staphylococcus aureus.
Journal of bacteriology 2005;187(8):2698-704.
2005: David G Biron; Hercules Moura; Laurent Marché; Austin Hughes; Frédéric Thomas
Towards a new conceptual approach to "parasitoproteomics".
Trends in parasitology 2005;21(4):162-8.
2005: Austin Hughes; Robert Friedman
Poxvirus genome evolution by gene gain and loss.
Molecular phylogenetics and evolution 2005;35(1):186-95.
2005: Robert Friedman; Austin Hughes
Codon volatility as an indicator of positive selection: data from eukaryotic genome comparisons.
Molecular biology and evolution 2005;22(3):542-6.
2005: Austin Hughes; Robert Friedman
Expression patterns of duplicate genes in the developing root in Arabidopsis thaliana.
Journal of molecular evolution 2005;60(2):247-56.
2005: Austin Hughes
Evidence for abundant slightly deleterious polymorphisms in bacterial populations.
Genetics 2005;169(2):533-8.
2005: Austin Hughes; Helen Piontkivska
DNA repeat arrays in chicken and human genomes and the adaptive evolution of avian genome size.
BMC evolutionary biology 2005;5():12.
2004: Amar Patil; Austin Hughes; Guolong Zhang
Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.
Physiological genomics 2004;20(1):1-11.
2004: Austin Hughes; Robert Friedman
Patterns of sequence divergence in 5' intergenic spacers and linked coding regions in 10 species of pathogenic bacteria reveal distinct recombinational histories.
Genetics 2004;168(4):1795-803.
2004: Austin Hughes; Robert Friedman
Shedding genomic ballast: extensive parallel loss of ancestral gene families in animals.
Journal of molecular evolution 2004;59(6):827-33.
2004: David O'Connor; Adrian B McDermott; Kendall C Krebs; Elizabeth J Dodds; Jacqueline E Miller; Edna J Gonzalez; Timothy J Jacoby; Levi J Yant; Helen Piontkivska; Ralph Pantophlet; Dennis R Burton; William M Rehrauer; Nancy Wilson; Austin Hughes; David Ian Watkins
A dominant role for CD8+-T-lymphocyte selection in simian immunodeficiency virus sequence variation.
Journal of virology 2004;78(24):14012-22.
2004: Austin Hughes
Evolutionary origin of the Jiv90 gene of Pestivirus.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2004;4(4):329-33.
2004: Helen Piontkivska; Austin Hughes
Between-host evolution of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1: an approach based on phylogenetically independent comparisons.
Journal of virology 2004;78(21):11758-65.
2004: Robert Friedman; Vikram Ekollu; John R Rose; Austin Hughes
Dblox: a genome-wide test for ancient segmental duplication.
Bioinformatics (Oxford, England) 2004;20(16):2834-5.
2004: Austin Hughes
The evolution of amino acid repeat arrays in Plasmodium and other organisms.
Journal of molecular evolution 2004;59(4):528-35.
2004: Peter Eck; Hans Christian Erichsen; James G Taylor; Meredith Yeager; Austin Hughes; Mark Levine; STEPHEN CHANOCK
Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2.
Human genetics 2004;115(4):285-94.
2004: Yanjing Xiao; Austin Hughes; Junko Ando; Yoichi Matsuda; Jan-Fang Cheng; Donald Skinner-Noble; Guolong Zhang
A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.
BMC genomics 2004;5(1):56.
2004: Henry Pollack; Zhiying Hou; Austin Hughes; William Borkowsky
Perinatal transmission and viral evolution of hepatitis C virus quasispecies in infants coinfected with HIV.
Journal of acquired immune deficiency syndromes (1999) 2004;36(4):890-9.
2004: Austin Hughes; Robert Friedman
Recent mammalian gene duplications: robust search for functionally divergent gene pairs.
Journal of molecular evolution 2004;59(1):114-20.
2004: Robert Friedman; John W Drake; Austin Hughes
Genome-wide patterns of nucleotide substitution reveal stringent functional constraints on the protein sequences of thermophiles.
Genetics 2004;167(3):1507-12.
2004: Austin Hughes; Robert Friedman
Pattern of divergence of amino acid sequences encoded by paralogous genes in human and pufferfish.
Molecular phylogenetics and evolution 2004;32(1):337-43.
2004: Austin Hughes
Comparative genomics: mining the crucial 1%.
Heredity 2004;93(1):5.
2004: Austin Hughes; Robert Friedman
Transposable element distribution in the yeast genome reflects a role in repeated genomic rearrangement events on an evolutionary time scale.
Genetica 2004;121(2):181-5.
2004: Austin Hughes
Phylogeny of the Picornaviridae and differential evolutionary divergence of picornavirus proteins.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2004;4(2):143-52.
2004: Robert Friedman; Austin Hughes
Two patterns of genome organization in mammals: the chromosomal distribution of duplicate genes in human and mouse.
Molecular biology and evolution 2004;21(6):1008-13.
2004: Thomas C Friedrich; Elizabeth J Dodds; Levi J Yant; Lara Vojnov; Richard Rudersdorf; Candice Cullen; David T Evans; Ronald C Desrosiers; Bianca R Mothé; John Sidney; Alessandro Sette; Kevin Kunstman; Steven Wolinsky; Michael Piatak; Jeffrey D Lifson; Austin Hughes; Nancy Wilson; David O'Connor; David Ian Watkins
Reversion of CTL escape-variant immunodeficiency viruses in vivo.
Nature medicine 2004;10(3):275-81.
2004: Thomas C Friedrich; Christopher A Frye; Levi J Yant; David O'Connor; Nancy A Kriewaldt; Meghan Benson; Lara Vojnov; Elizabeth J Dodds; Candice Cullen; Richard Rudersdorf; Austin Hughes; Nancy Wilson; David Ian Watkins
Extraepitopic compensatory substitutions partially restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic-T-lymphocyte response.
Journal of virology 2004;78(5):2581-5.
2004: Austin Hughes; Robert Friedman
Differential loss of ancestral gene families as a source of genomic divergence in animals.
Proceedings. Biological sciences / The Royal Society 2004;271 Suppl 3():S107-9.
2004: Austin Hughes
Birth-and-death evolution of protein-coding regions and concerted evolution of non-coding regions in the multi-component genomes of nanoviruses.
Molecular phylogenetics and evolution 2004;30(2):287-94.
2003: Austin Hughes; Bernice Packer; Robert Welch; Andrew W Bergen; STEPHEN CHANOCK; Meredith Yeager
Widespread purifying selection at polymorphic sites in human protein-coding loci.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15754-7.
2003: Austin Hughes; Robert Friedman; Vikram Ekollu; John R Rose
Non-random association of transposable elements with duplicated genomic blocks in Arabidopsis thaliana.
Molecular phylogenetics and evolution 2003;29(3):410-6.
2003: Austin Hughes; Jonathan A Green; Helen Piontkivska; R Michael Roberts
Aspartic proteinase phylogeny and the origin of pregnancy-associated glycoproteins.
Molecular biology and evolution 2003;20(11):1940-5.
2003: David O'Connor; Bianca R Mothe; Jason T Weinfurter; Sarah Fuenger; William M Rehrauer; Peicheng Jing; Richard Rudersdorf; Max E Liebl; Kendall C Krebs; Joshua Vasquez; Elizabeth J Dodds; John T Loffredo; Sarah Martin; Adrian B McDermott; Todd M Allen; Chenxi Wang; Gaby G M Doxiadis; David C Montefiori; Austin Hughes; Dennis R Burton; David Allison; Steven Wolinsky; Ronald E Bontrop; Louis J Picker; David Ian Watkins
Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses.
Journal of virology 2003;77(16):9029-40.
2003: Austin Hughes; Robert Friedman
Parallel evolution by gene duplication in the genomes of two unicellular fungi.
Genome research 2003;13(6A):1259-64.
2003: Austin Hughes; Robert Friedman
Genome-wide survey for genes horizontally transferred from cellular organisms to baculoviruses.
Molecular biology and evolution 2003;20(6):979-87.
2003: Austin Hughes; Robert Friedman
Parallel evolution by gene duplication in the genomes of two unicellular fungi.
Genome research 2003;13(5):794-9.
2003: Austin Hughes; Helen Piontkivska
Phylogeny of Trypanosomatidae and Bodonidae (Kinetoplastida) based on 18S rRNA: evidence for paraphyly of Trypanosoma and six other genera.
Molecular biology and evolution 2003;20(4):644-52.
2003: Alessandro Sette; John Sidney; Brian D Livingston; John Dzuris; Claire Crimi; Christopher M Walker; Scott Southwood; Edward J Collins; Austin Hughes
Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution.
Immunogenetics 2003;54(12):830-41.
2003: Helen Piontkivska; Austin Hughes
Evolution of vertebrate voltage-gated ion channel alpha chains by sequential gene duplication.
Journal of molecular evolution 2003;56(3):277-85.
2003: Austin Hughes
Genomes of mice and men.
Heredity 2003;90(2):115-7.
2003: Austin Hughes; Robert Friedman
2R or not 2R: testing hypotheses of genome duplication in early vertebrates.
Journal of structural and functional genomics 2003;3(1-4):85-93.
2003: Robert Friedman; Austin Hughes
The temporal distribution of gene duplication events in a set of highly conserved human gene families.
Molecular biology and evolution 2003;20(1):154-61.
2003: Arman Bashirova; Li Wu; Jie Cheng; Thomas D Martin; Maureen P Martin; Raoul E Benveniste; Jeffrey D Lifson; Vineet N KewalRamani; Austin Hughes; Mary Carrington
Novel member of the CD209 (DC-SIGN) gene family in primates.
Journal of virology 2003;77(1):217-27.
2002: Austin Hughes
Natural selection and the diversification of vertebrate immune effectors.
Immunological reviews 2002;190():161-8.
2002: Perris Flügge; Elke Zimmermann; Austin Hughes; Eberhard Günther; Lutz Walter
Characterization and phylogenetic relationship of prosimian MHC class I genes.
Journal of molecular evolution 2002;55(6):768-75.
2002: Austin Hughes; Robert Friedman; Megan Murray
Genomewide pattern of synonymous nucleotide substitution in two complete genomes of Mycobacterium tuberculosis.
Emerging infectious diseases 2002;8(11):1342-6.
2002: Austin Hughes
Evolution of the human killer cell inhibitory receptor family.
Molecular phylogenetics and evolution 2002;25(2):330-40.
2002: Thorsten U Vogel; Thomas C Friedrich; David O'Connor; William M Rehrauer; Elizabeth J Dodds; Heather D Hickman; William H Hildebrand; John Sidney; Alessandro Sette; Austin Hughes; Helen Horton; Kathy Vielhuber; Richard Rudersdorf; Ivna P De Souza; Matthew R Reynolds; Todd M Allen; Nancy Wilson; David Ian Watkins
Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?
Journal of virology 2002;76(22):11623-36.
2002: Austin Hughes
Evolution of inhibitors of apoptosis in baculoviruses and their insect hosts.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2002;2(1):3-10.
2002: Somchai Jongwutiwes; Chaturong Putaporntip; Robert Friedman; Austin Hughes
The extent of nucleotide polymorphism is highly variable across a 3-kb region on Plasmodium falciparum chromosome 2.
Molecular biology and evolution 2002;19(9):1585-90.
2002: Austin Hughes
Adaptive evolution after gene duplication.
Trends in genetics : TIG 2002;18(9):433-4.
2002: Austin Hughes; Federica Verra
Extensive polymorphism and ancient origin of Plasmodium falciparum.
Trends in parasitology 2002;18(8):348-51.
2002: Austin Hughes
Strength in numbers.
Nature 2002;417(6891):795.
2002: David O'Connor; Todd M Allen; Thorsten U Vogel; Peicheng Jing; Ivan P DeSouza; Elizabeth J Dodds; Edward J Dunphy; Cheri Melsaether; Bianca R Mothé; Hiroshi Yamamoto; Helen Horton; Nancy Wilson; Austin Hughes; David Ian Watkins
Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection.
Nature medicine 2002;8(5):493-9.
2002: Leonard Lipovich; Austin Hughes; Mary-Claire King; Janis L Abkowitz; John Quigley
Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus.
Gene 2002;286(2):203-13.
2002: Robert Friedman; Austin Hughes
Molecular evolution of the NF-kappaB signaling system.
Immunogenetics 2002;53(10-11):964-74.
2002: Austin Hughes
Origin and evolution of viral interleukin-10 and other DNA virus genes with vertebrate homologues.
Journal of molecular evolution 2002;54(1):90-101.
2001: Austin Hughes
Evolutionary change of predicted cytotoxic T cell epitopes of dengue virus.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2001;1(2):123-30.
2001: AL Erickson; Y Kimura; S Igarashi; J Eichelberger; Michael Houghton; John Sidney; Denise McKinney; Alessandro Sette; Austin Hughes; Christopher M Walker
The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes.
Immunity 2001;15(6):883-95.
2001: Richard L Grendell; Austin Hughes; Thaddeus G Golos
Cloning of rhesus monkey killer-cell Ig-like receptors (KIRs) from early pregnancy decidua.
Tissue antigens 2001;58(5):329-34.
2001: Robert Friedman; Austin Hughes
Pattern and timing of gene duplication in animal genomes.
Genome research 2001;11(11):1842-7.
2001: D O'Connor; T Friedrich; Austin Hughes; T M Allen; D Watkins
Understanding cytotoxic T-lymphocyte escape during simian immunodeficiency virus infection.
Immunological reviews 2001;183():115-26.
2001: K M Westover; Austin Hughes
Molecular evolution of viral fusion and matrix protein genes and phylogenetic relationships among the Paramyxoviridae.
Molecular phylogenetics and evolution 2001;21(1):128-34.
2001: Austin Hughes; F Verra
Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum.
Proceedings. Biological sciences / The Royal Society 2001;268(1478):1855-60.
2001: Austin Hughes; K Westover; J da Silva; David O'Connor; David Ian Watkins
Simultaneous positive and purifying selection on overlapping reading frames of the tat and vpr genes of simian immunodeficiency virus.
Journal of virology 2001;75(17):7966-72.
2001: Austin Hughes; J da Silva; Robert Friedman
Ancient genome duplications did not structure the human Hox-bearing chromosomes.
Genome research 2001;11(5):771-80.
2001: Robert Friedman; Austin Hughes
Gene duplication and the structure of eukaryotic genomes.
Genome research 2001;11(3):373-81.
2001: Xi Wang; Austin Hughes; Tatsuya Tsukamoto; Toshio Ando; T Kao
Evidence that intragenic recombination contributes to allelic diversity of the S-RNase gene at the self-incompatibility (S) locus in Petunia inflata.
Plant physiology 2001;125(2):1012-22.
2001: Austin Hughes
Evolution of the integrin alpha and beta protein families.
Journal of molecular evolution 2001;52(1):63-72.
2000: Austin Hughes; Robert Friedman
Evolutionary diversification of protein-coding genes of hantaviruses.
Molecular biology and evolution 2000;17(10):1558-68.
2000: Todd M Allen; David O'Connor; Peicheng Jing; John Dzuris; Bianca R Mothé; Thorsten U Vogel; E Dunphy; Max E Liebl; C Emerson; Nancy Wilson; Kevin Kunstman; X Wang; David Allison; Austin Hughes; Ronald C Desrosiers; John D Altman; Steven Wolinsky; Alessandro Sette; David Ian Watkins
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia.
Nature 2000;407(6802):386-90.
2000: Austin Hughes; P Pontarotti
Gene duplication and MHC origins.
Immunogenetics 2000;51(11):982-3.
2000: Austin Hughes; R Michael Roberts
Independent origin of IFN-alpha and IFN-beta in birds and mammals.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(8):737-9.
2000: Austin Hughes
Evolution of introns and exons of class II major histocompatibility complex genes of vertebrates.
Immunogenetics 2000;51(6):473-86.
2000: Austin Hughes; Jonathan A Green; Juana M Garbayo; R Michael Roberts
Adaptive diversification within a large family of recently duplicated, placentally expressed genes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3319-23.
2000: Austin Hughes
Modes of evolution in the protease and kringle domains of the plasminogen-prothrombin family.
Molecular phylogenetics and evolution 2000;14(3):469-78.
2000: JA Urvater; Nel Otting; J H Loehrke; RA Rudersdorf; Igor I Slukvin; Marian Piekarczyk; Thaddeus G Golos; Austin Hughes; Ronald E Bontrop; David Ian Watkins
Mamu-I: a novel primate MHC class I B-related locus with unusually low variability.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1386-98.
2000: F Verra; Austin Hughes
Evidence for ancient balanced polymorphism at the Apical Membrane Antigen-1 (AMA-1) locus of Plasmodium falciparum.
Molecular and biochemical parasitology 2000;105(1):149-53.
2000: M Yeager; M Carrington; Austin Hughes
Class I and class II MHC bind self peptide sets that are strikingly different in their evolutionary characteristics.
Immunogenetics 2000;51(1):8-15.
1999: Austin Hughes
Concerted evolution of exons and introns in the MHC-linked tenascin-X gene of mammals.
Molecular biology and evolution 1999;16(11):1558-67.
1999: David T Evans; David O'Connor; Peicheng Jing; John Dzuris; John Sidney; J da Silva; Todd M Allen; Helen Horton; J E Venham; RA Rudersdorf; T Vogel; C. David Pauza; Ronald E Bontrop; R DeMars; Alessandro Sette; Austin Hughes; David Ian Watkins
Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.
Nature medicine 1999;5(11):1270-6.
1999: Austin Hughes
Evolutionary diversification of the mammalian defensins.
Cellular and molecular life sciences : CMLS 1999;56(1-2):94-103.
1999: J da Silva; Austin Hughes
Molecular phylogenetic evidence of cytotoxic T lymphocyte (CTL) selection on human immunodeficiency virus type 1 (HIV-1)
Molecular biology and evolution 1999;16(10):1420-2.
1999: F Verra; Austin Hughes
Natural selection on apical membrane antigen-1 of Plasmodium falciparum.
Parassitologia 1999;41(1-3):93-5.
1999: F Verra; Austin Hughes
Biased amino acid composition in repeat regions of Plasmodium antigens.
Molecular biology and evolution 1999;16(5):627-33.
1999: Austin Hughes
Phylogenies of developmentally important proteins do not support the hypothesis of two rounds of genome duplication early in vertebrate history.
Journal of molecular evolution 1999;48(5):565-76.
1999: Thorsten U Vogel; David T Evans; JA Urvater; David O'Connor; Austin Hughes; David Ian Watkins
Major histocompatibility complex class I genes in primates: co-evolution with pathogens.
Immunological reviews 1999;167():327-37.
1999: M Yeager; Austin Hughes
Evolution of the mammalian MHC: natural selection, recombination, and convergent evolution.
Immunological reviews 1999;167():45-58.
1999: Yuka Tasaki; S Fukuda; M Iio; Retsu Miura; Teruko Imai; S Sugano; Osamu Yoshie; Austin Hughes; Hisayuki Nomiyama
Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes.
Genomics 1999;55(3):353-7.
1999: Austin Hughes; M Yeager
Coevolution of the mammalian chemokines and their receptors.
Immunogenetics 1999;49(2):115-24.
1999: Austin Hughes
Evolution of the arthropod prophenoloxidase/hexamerin protein family.
Immunogenetics 1999;49(2):106-14.
1999: Jonathan Boyson; KK Iwanaga; JA Urvater; Austin Hughes; Thaddeus G Golos; David Ian Watkins
Evolution of a new nonclassical MHC class I locus in two Old World primate species.
Immunogenetics 1999;49(2):86-98.
1999: Austin Hughes
Genomic catastrophism and the origin of vertebrate immunity.
Archivum immunologiae et therapiae experimentalis 1999;47(6):347-53.
1999: Austin Hughes; M Yeager; AE Ten Elshof; Michael J Chorney
A new taxonomy of mammalian MHC class I molecules.
Immunology today 1999;20(1):22-6.
1998: J da Silva; Austin Hughes
Conservation of cytotoxic T lymphocyte (CTL) epitopes as a host strategy to constrain parasite adaptation: evidence from the nef gene of human immunodeficiency virus 1 (HIV-1).
Molecular biology and evolution 1998;15(10):1259-68.
1998: Austin Hughes; F Verra
Ancient polymorphism and the hypothesis of a recent bottleneck in the malaria parasite Plasmodium falciparum.
Genetics 1998;150(1):511-3.
1998: Austin Hughes
Phylogenetic tests of the hypothesis of block duplication of homologous genes on human chromosomes 6, 9, and 1.
Molecular biology and evolution 1998;15(7):854-70.
1998: Austin Hughes; M Yeager
Natural selection and the evolutionary history of major histocompatibility complex loci.
Frontiers in bioscience : a journal and virtual library 1998;3():d509-16.
1998: Austin Hughes
Protein phylogenies provide evidence of a radical discontinuity between arthropod and vertebrate immune systems.
Immunogenetics 1998;47(4):283-96.
1998: Austin Hughes; M Yeager
Natural selection at major histocompatibility complex loci of vertebrates.
Annual review of genetics 1998;32():415-35.
1997: LF Cadavid; C Shufflebotham; F J Ruiz; M Yeager; Austin Hughes; David Ian Watkins
Evolutionary instability of the major histocompatibility complex class I loci in New World primates.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14536-41.
1997: M Yeager; Sudhir Kumar; Austin Hughes
Sequence convergence in the peptide-binding region of primate and rodent MHC class Ib molecules.
Molecular biology and evolution 1997;14(10):1035-41.
1997: Austin Hughes; M Yeager
Molecular evolution of the vertebrate immune system.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(9):777-86.
1997: Austin Hughes; M Yeager
Comparative evolutionary rates of introns and exons in murine rodents.
Journal of molecular evolution 1997;45(2):125-30.
1997: David T Evans; Marian Piekarczyk; Todd M Allen; Jonathan Boyson; M Yeager; Austin Hughes; F M Gotch; VS Hinshaw; David Ian Watkins
Immunodominance of a single CTL epitope in a primate species with limited MHC class I polymorphism.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1374-82.
1997: LM Schwiebert; Austin Hughes; D S Monos; Santa Jeremy Ono
HLA-DRA promoter polymorphism and diversity generation within the immune system.
Human genetics 1997;99(6):801-5.
1997: Austin Hughes; M Yeager
Coordinated amino acid changes in the evolution of mammalian defensins.
Journal of molecular evolution 1997;44(6):675-82.
1997: N Cereb; C Kim; Austin Hughes; SY Yang
Molecular analysis of HLA-B35 alleles and their relationship to HLA-B15 alleles.
Tissue antigens 1997;49(4):389-96.
1997: N Cereb; Austin Hughes; SY Yang
Cw*1701, a new HLA-C allelic lineage with an unusual transmembrane domain.
Tissue antigens 1997;49(3 Pt 1):252-5.
1997: N Cereb; Austin Hughes; SY Yang
Locus-specific conservation of the HLA class I introns by intra-locus homogenization.
Immunogenetics 1997;47(1):30-6.
1997: Austin Hughes
Evolution of the proteasome components.
Immunogenetics 1997;46(2):82-92.
1997: Guan K Tay; Chanvit Leelayuwat; M J Chorney; SK Cattley; Peter N Hollingsworth; Campbell S Witt; L N Daly; Austin Hughes; Roger L Dawkins
The MHC contains multiple genes potentially relevant to hemochromatosis.
Immunogenetics 1997;45(5):336-40.
1997: Austin Hughes
Rapid evolution of immunoglobulin superfamily C2 domains expressed in immune system cells.
Molecular biology and evolution 1997;14(1):1-5.
1996: Austin Hughes; M Yeager; M Carrington
Peptide binding function and the paradox of HLA disease associations.
Immunology and cell biology 1996;74(5):444-8.
1996: LF Cadavid; Austin Hughes; David Ian Watkins
MHC class I-processed pseudogenes in New World primates provide evidence for rapid turnover of MHC class I genes.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2403-9.
1996: Austin Hughes
Gene duplication and recombination in the evolution of mammalian Fc receptors.
Journal of molecular evolution 1996;43(1):4-10.
1996: Jonathan Boyson; C Shufflebotham; LF Cadavid; JA Urvater; LA Knapp; Austin Hughes; David Ian Watkins
The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primates.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4656-65.
1996: A S Greenberg; Austin Hughes; J Guo; D Avila; E Churchill McKinney; Martin F Flajnik
A novel "chimeric" antibody class in cartilaginous fish: IgM may not be the primordial immunoglobulin.
European journal of immunology 1996;26(5):1123-9.
1996: Austin Hughes
Evolution of the src-related protein tyrosine kinases.
Journal of molecular evolution 1996;42(2):247-56.
1996: Dianna M Milewicz; P H Byers; J Reveille; Austin Hughes; M Duvic
A dimorphic Alu Sb-like insertion in COL3A1 is ethnic-specific.
Journal of molecular evolution 1996;42(2):117-23.
1996: Todd M Allen; J S Lanchbury; Austin Hughes; David Ian Watkins
The T-cell receptor beta chain-encoding gene repertoire of a New World primate species, the cotton-top tamarin.
Immunogenetics 1996;45(2):151-60.
1996: M Yeager; Austin Hughes
Interallelic recombination has not played a major role in the history of the HLA-C locus.
Immunogenetics 1996;44(2):128-33.
1995: Austin Hughes
The evolution of the type I interferon gene family in mammals.
Journal of molecular evolution 1995;41(5):539-48.
1995: Austin Hughes; M K Hughes
Small genomes for better flyers.
Nature 1995;377(6548):391.
1995: S A Seibert; C Y Howell; M K Hughes; Austin Hughes
Natural selection on the gag, pol, and env genes of human immunodeficiency virus 1 (HIV-1).
Molecular biology and evolution 1995;12(5):803-13.
1995: S McAdam; Jonathan Boyson; X Liu; T L Garber; Austin Hughes; R E Bontrop; David Ian Watkins
Chimpanzee MHC class I A locus alleles are related to only one of the six families of human A locus alleles.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6421-9.
1995: M K Hughes; Austin Hughes
Natural selection on Plasmodium surface proteins.
Molecular and biochemical parasitology 1995;71(1):99-113.
1995: A Weiner; A L Erickson; J Kansopon; K Crawford; E Muchmore; Austin Hughes; Michael Houghton; C M Walker
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2755-9.
1995: A S Greenberg; D Avila; M Hughes; Austin Hughes; E Churchill McKinney; Martin F Flajnik
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks.
Nature 1995;374(6518):168-73.
1995: Austin Hughes
Origin and evolution of HLA class I pseudogenes.
Molecular biology and evolution 1995;12(2):247-58.
1995: Jonathan Boyson; S McAdam; A Gallimore; Thaddeus G Golos; X Liu; F M Gotch; Austin Hughes; David Ian Watkins
The MHC E locus in macaques is polymorphic and is conserved between macaques and humans.
Immunogenetics 1995;41(2-3):59-68.
1995: Austin Hughes; M K Hughes
Natural selection on the peptide-binding regions of major histocompatibility complex molecules.
Immunogenetics 1995;42(4):233-43.
1995: Austin Hughes; M K Hughes
Self peptides bound by HLA class I molecules are derived from highly conserved regions of a set of evolutionarily conserved proteins.
Immunogenetics 1995;41(5):257-62.
1994: Austin Hughes
Evolution of cysteine proteinases in eukaryotes.
Molecular phylogenetics and evolution 1994;3(4):310-21.
1994: Austin Hughes; M K Hughes; C Y Howell; M Nei
Natural selection at the class II major histocompatibility complex loci of mammals.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;346(1317):359-66; discussion 366-7.
1994: Somchai Jongwutiwes; K Tanabe; M K Hughes; Hiroji Kanbara; Austin Hughes
Allelic variation in the circumsporozoite protein of Plasmodium falciparum from Thai field isolates.
The American journal of tropical medicine and hygiene 1994;51(5):659-68.
1994: Austin Hughes
Evolution of the ATP-binding-cassette transmembrane transporters of vertebrates.
Molecular biology and evolution 1994;11(6):899-910.
1994: Austin Hughes
Evolution of the interleukin-1 gene family in mammals.
Journal of molecular evolution 1994;39(1):6-12.
1994: S McAdam; Jonathan Boyson; X Liu; T L Garber; Austin Hughes; R E Bontrop; David Ian Watkins
A uniquely high level of recombination at the HLA-B locus.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):5893-7.
1994: Austin Hughes
The evolution of functionally novel proteins after gene duplication.
Proceedings. Biological sciences / The Royal Society 1994;256(1346):119-24.
1994: Austin Hughes
Phylogeny of the C3/C4/C5 complement-component gene family indicates that C5 diverged first.
Molecular biology and evolution 1994;11(3):417-25.
1994: Austin Hughes
Conserved proteins as immunogens: glutathione S-transferase of Schistosoma.
Parasitology today (Personal ed.) 1994;10(4):149-51.
1994: T L Garber; Austin Hughes; David Ian Watkins; J W Templeton
Evidence for at least three transcribed BoLA class I loci.
Immunogenetics 1994;39(4):257-65.
1993: M K Hughes; Austin Hughes
Evolution of duplicate genes in a tetraploid animal, Xenopus laevis.
Molecular biology and evolution 1993;10(6):1360-9.
1993: A G Wagner; Austin Hughes; M L Iandoli; D Stewart; S Herbert; David Ian Watkins; Carolyn Katovich Hurley; S Rosen-Bronson
HLA-A*8001 is a member of a newly discovered ancient family of HLA-A alleles.
Tissue antigens 1993;42(5):522-9.
1993: Austin Hughes
Contrasting evolutionary rates in the duplicate chaperonin genes of Mycobacterium tuberculosis and M. leprae.
Molecular biology and evolution 1993;10(6):1343-59.
1993: Austin Hughes; M K Hughes
Adaptive evolution in the rat olfactory receptor gene family.
Journal of molecular evolution 1993;36(3):249-54.
1993: Austin Hughes
Rates of amino acid evolution in the 26- and 28-kDa glutathione S-transferases of Schistosoma.
Molecular and biochemical parasitology 1993;58(1):43-52.
1993: Austin Hughes; M K Hughes; David Ian Watkins
Contrasting roles of interallelic recombination at the HLA-A and HLA-B loci.
Genetics 1993;133(3):669-80.
1993: Zheng W Chen; Austin Hughes; S H Ghim; Norman L Letvin; David Ian Watkins
Two more chimpanzee Patr-A locus alleles related to the HLA-A1/A3/A11 family.
Immunogenetics 1993;38(3):238-40.
1993: Austin Hughes
Evidence of positive selection at the Lyb-2 locus of the mouse.
Immunogenetics 1993;38(1):54-6.
1993: T L Garber; Austin Hughes; Norman L Letvin; J W Templeton; David Ian Watkins
Sequence and evolution of cattle MHC class I cDNAs: concerted evolution has not taken place in cattle.
Immunogenetics 1993;38(1):11-20.
1993: Austin Hughes
Nonlinear relationships among evolutionary rates identify regions of functional divergence in heat-shock protein 70 genes.
Molecular biology and evolution 1993;10(1):243-55.
1993: Austin Hughes; Masatoshi Nei
Evolutionary relationships of the classes of major histocompatibility complex genes.
Immunogenetics 1993;37(5):337-46.
1992: Zheng W Chen; Ling Shen; M Miller; S H Ghim; Austin Hughes; Norman L Letvin
Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):4060-6.
1992: Austin Hughes; M Nei
Models of host-parasite interaction and MHC polymorphism.
Genetics 1992;132(3):863-4.
1992: Lakshmi K Gaur; Austin Hughes; E R Heise; J Gutknecht
Maintenance of DQB1 polymorphisms in primates.
Molecular biology and evolution 1992;9(4):599-609.
1992: Austin Hughes
Positive selection and interallelic recombination at the merozoite surface antigen-1 (MSA-1) locus of Plasmodium falciparum.
Molecular biology and evolution 1992;9(3):381-93.
1992: Zheng W Chen; S McAdam; Austin Hughes; A L Dogon; Norman L Letvin; David Ian Watkins
Molecular cloning of orangutan and gibbon MHC class I cDNA. The HLA-A and -B loci diverged over 30 million years ago.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2547-54.
1992: Austin Hughes
Coevolution of the vertebrate integrin alpha- and beta-chain genes.
Molecular biology and evolution 1992;9(2):216-34.
1992: Austin Hughes; M Nei
Maintenance of MHC polymorphism.
Nature 1992;355(6359):402-3.
1992: G Levinson; Austin Hughes; Norman L Letvin
Sequence and diversity of rhesus monkey T-cell receptor beta chain genes.
Immunogenetics 1992;35(2):75-88.
1991: L J Zhou; D C Ord; Austin Hughes; Thomas F Tedder
Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1424-32.
1991: M Miller; H Yamamoto; Austin Hughes; David Ian Watkins; Norman L Letvin
Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):320-9.
1991: Austin Hughes
Evolutionary origin and diversification of the mammalian CD1 antigen genes.
Molecular biology and evolution 1991;8(2):185-201.
1991: Austin Hughes
Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenic regions.
Genetics 1991;127(2):345-53.
1991: Austin Hughes
Independent gene duplications, not concerted evolution, explain relationships among class I MHC genes of murine rodents.
Immunogenetics 1991;33(5-6):367-73.
1991: Austin Hughes
Testing for interlocus genetic exchange in the MHC: a reply to Andersson and co-workers.
Immunogenetics 1991;33(4):243-6.
1991: David Ian Watkins; Zheng W Chen; T L Garber; Austin Hughes; Norman L Letvin
Segmental exchange between MHC class I genes in a higher primate: recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene.
Immunogenetics 1991;34(3):185-91.
1991: David Ian Watkins; T L Garber; Zheng W Chen; G Toukatly; Austin Hughes; Norman L Letvin
Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus).
Immunogenetics 1991;33(2):79-89.
1990: David Ian Watkins; Zheng W Chen; Austin Hughes; A Lagos; A M Lewis; J A Shadduck; Norman L Letvin
Syrian hamsters express diverse MHC class I gene products.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(10):3483-90.
1990: Austin Hughes; T Ota; M Nei
Positive Darwinian selection promotes charge profile diversity in the antigen-binding cleft of class I major-histocompatibility-complex molecules.
Molecular biology and evolution 1990;7(6):515-24.
1990: Austin Hughes; M Nei
Evolutionary relationships of class II major-histocompatibility-complex genes in mammals.
Molecular biology and evolution 1990;7(6):491-514.
1990: David Ian Watkins; Zheng W Chen; Austin Hughes; M G Evans; T F Tedder; Norman L Letvin
Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes.
Nature 1990;346(6279):60-3.
1990: David Ian Watkins; Zheng W Chen; Austin Hughes; F S Hodi; Norman L Letvin
Genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar MHC class I gene products.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3726-35.
1990: David Ian Watkins; Norman L Letvin; Austin Hughes; T F Tedder
Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(3):1136-43.
1989: Austin Hughes; M Nei
Evolution of the major histocompatibility complex: independent origin of nonclassical class I genes in different groups of mammals.
Molecular biology and evolution 1989;6(6):559-79.
1989: Austin Hughes
Interaction between strains in the social relations of inbred mice.
Behavior genetics 1989;19(5):685-700.
1989: Austin Hughes; M Nei
Ancient interlocus exon exchange in the history of the HLA-A locus.
Genetics 1989;122(3):681-6.
1989: Austin Hughes; M Nei
Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):958-62.
1988: Austin Hughes; M Nei
Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection.
Nature 1988;335(6186):167-70.
1986: Austin Hughes
Reproductive success and occupational class in eighteenth-century Lancashire, England.
Social biology 1986;33(1-2):109-15.