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Dennis Carson

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Raymond P Wu; Tomoko Hayashi; Thomas J Kipps; Hongying Li; Karen Messer; Laura Rassenti; Christina N Wu; Dennis A Carson
Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia.
Christian L Barrett; Dennis A Carson; Brian Crain; Daniel J Goff; Olivier Harismendy; Catriona H M Jamieson; HyunChul Jung; Richard B Schwab; Patricia A Thistlethwaite; Kelly A Frazer
Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer.
John T Norton; John S Cho; Maripat Corr; Brian Crain; Tomoko Hayashi; Lloyd S Miller; Dennis A Carson
Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.

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2013: Raymond P Wu; Tomoko Hayashi; Thomas J Kipps; Hongying Li; Karen Messer; Laura Rassenti; Christina N Wu; Dennis A Carson
Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia.
Leukemia & lymphoma 2013;54(2):400-2.
2013: Christian L Barrett; Dennis A Carson; Brian Crain; Daniel J Goff; Olivier Harismendy; Catriona H M Jamieson; HyunChul Jung; Richard B Schwab; Patricia A Thistlethwaite; Kelly A Frazer
Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer.
PloS one 2013;8(3):e58714.
2012: John T Norton; John S Cho; Maripat Corr; Brian Crain; Tomoko Hayashi; Lloyd S Miller; Dennis A Carson
Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(7):2977-80.
2012: Tomoko Hayashi; Fitzgerald Lao; Rommel I Tawatao; Linda Vuong; Shiyin Yao; Dennis A Carson; Michael Chan; Howard B Cottam; Brian Crain; Christine Gray; Maripat Corr
Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.
PloS one 2012;7(9):e45860.
2012: Wenxue Ma; Sheldon R Morris; Anil Sadarangani; Alice Y Shih; Kristen M Smith; Ping Wei; Christina C Wu; QINGFEI JIANG; Kang Li; A Thomas Look; Dennis A Carson; Angela C Court; Leslie Crews; Ida Deichaite; Ifat Geron; Neil W Gibson; Daniel J Goff; Alejandro Gutierrez; Christina A M Jamieson; Catriona H M Jamieson
NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
PloS one 2012;7(6):e39725.
2012: Tomoko Hayashi; Fitzgerald Lao; Shiyin Yao; Dennis A Carson; Michael Chan; Howard B Cottam; Brian Crain; Maripat Corr
Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand.
Mediators of inflammation 2012;2012():262394.
2012: Annelies S Zinkernagel; Reto A Schuepbach; Satoshi Uchiyama; Maren von Köckritz-Blickwede; Dennis A Carson; Tomoko Hayashi; Petr Hruz; Victor Nizet
Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.
Journal of innate immunity 2012;4(2):213-8.
2011: Desheng Lu; Jian Yu; Januario E Castro; Michael Y Choi; Thomas J Kipps; Dennis A Carson
Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13253-7.
2011: Desheng Lu; Dennis A Carson
Inhibition of Wnt signaling and cancer stem cells.
Oncotarget 2011;2(8):587.
2011: John T Norton; Maripat Corr; Brian Crain; Tomoko Hayashi; Dennis A Carson
Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(27):11163-8.
2011: Michael Chan; Tomoko Hayashi; Richard D Mathewson; Shiyin Yao; Christine Gray; Rommel I Tawatao; Kevin Kalenian; Yanmei Zhang; Yuki Hayashi; Fitzgerald S Lao; Howard B Cottam; Dennis A Carson
Synthesis and characterization of PEGylated toll like receptor 7 ligands.
Bioconjugate chemistry 2011;22(3):445-54.
2010: Desheng Lu; Dennis A Carson
Repression of beta-catenin signaling by PPAR gamma ligands.
European journal of pharmacology 2010;636(1-3):198-202.
2010: Tomoko Hayashi; Brian Crain; Maripat Corr; Michael Chan; Howard B Cottam; Roberto Maj; Alcide Barberis; Lorenzo Leoni; Dennis A Carson
Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer.
International journal of urology : official journal of the Japanese Urological Association 2010;17(5):483-90.
2009: Michael Chan; Tomoko Hayashi; Crystal S Kuy; Christine S Gray; Christina C N Wu; Maripat Corr; Wolfgang Wrasidlo; Howard B Cottam; Dennis A Carson
Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates.
Bioconjugate chemistry 2009;20(6):1194-200.
2009: Tomoko Hayashi; Christine S Gray; Michael Chan; Rommel I Tawatao; Lisa Ronacher; Maureen A McGargill; Sandip K Datta; Dennis A Carson; Maripat Corr
Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2764-9.
2009: Guangyi Jin; Desheng Lu; Shiyin Yao; Christina C N Wu; Jerry X Liu; Dennis A Carson; Howard B Cottam
Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival.
Bioorganic & medicinal chemistry letters 2009;19(3):606-9.
2009: Desheng Lu; Jerry X Liu; Tomoyuki Endo; Haowen Zhou; Shiyin Yao; Karl Willert; Ingo G H Schmidt-Wolf; Thomas J Kipps; Dennis A Carson
Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.
PloS one 2009;4(12):e8294.
2009: Desheng Lu; Dennis A Carson
Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway.
BMC pharmacology 2009;9():13.
2008: Qing Lu; Esperanza Nunez; Chunrun Lin; Kimberly Christensen; Tracy Downs; Dennis A Carson; Jessica Wang-Rodriguez; Yu-Tsueng Liu
A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants.
Nucleic acids research 2008;36(20):e130.
2008: Tomoko Hayashi; Howard B Cottam; Michael Chan; Guangyi Jin; Rommel I Tawatao; Brian Crain; Lisa Ronacher; Karen Messer; Dennis A Carson; Maripat Corr
Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(1):R123-32.
2008: Tetsuya Fukuda; Liguang Chen; Tomoyuki Endo; Li Tang; Desheng Lu; Januario E Castro; George F Widhopf; Laura Rassenti; Mark J Cantwell; Charles E Prussak; Dennis A Carson; Thomas Kipps
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):3047-52.
2008: Christina C N Wu; Mojgan Sabet; Tomoko Hayashi; Rommel I Tawatao; Joshua Fierer; Dennis A Carson; Donald G Guiney; Maripat Corr
In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model.
Cellular immunology 2008;251(2):78-85.
2007: April J Livengood; Christina C N Wu; Dennis A Carson
Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi's sarcoma cell line.
Cellular immunology 2007;249(2):55-62.
2007: Christina C N Wu; Tomoko Hayashi; Kenji Takabayashi; Mojgan Sabet; Donald F Smee; Donald D Guiney; Howard B Cottam; Dennis A Carson
Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3990-5.
2006: Guangyi Jin; Christina C N Wu; Rommel I Tawatao; Michael Chan; Dennis A Carson; Howard B Cottam
Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists.
Bioorganic & medicinal chemistry letters 2006;16(17):4559-63.
2006: Dale L Barnard; Craig W Day; Kevin Bailey; Matthew Heiner; Robert Montgomery; Larry Lauridsen; Scott G Winslow; Justin Hoopes; Joseph K-K Li; Jongdae Lee; Dennis A Carson; Howard B Cottam; Robert W Sidwell
Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin.
Antiviral research 2006;71(1):53-63.
2006: Januario E Castro; Carlos E Prada; R A Aguillon; S Kitada; Tetsuya Fukuda; M Motta; C Wu; Frank Dicker; G Sun; J Y J Wang; Dennis A Carson; J C Reed; Thomas Kipps
Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference.
Leukemia 2006;20(4):680-8.
2006: Jongdae Lee; Christina C N Wu; Ki Jeong Lee; Tsung-Hsien Chuang; Kyoko Katakura; Yu-Tsueng Liu; Michael Chan; Rommel I Tawatao; Michelle Chung; Carol Shen; Howard B Cottam; Michael M C Lai; Eyal Raz; Dennis A Carson
Activation of anti-hepatitis C virus responses via Toll-like receptor 7.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1828-33.
2006: Guangyi Jin; Christina C N Wu; Dennis A Carson; Howard B Cottam
Guanosine analog in the pyrido[2,3-d]pyrimidine ring system as a potential toll-like receptor agonist.
Nucleosides, nucleotides & nucleic acids 2006;25(12):1391-7.
2005: Desheng Lu; Howard B Cottam; Maripat Corr; Dennis A Carson
Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18567-71.
2005: Sylvie D Barchéchath; Rommel I Tawatao; Maripat Corr; Dennis A Carson; Howard B Cottam
Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha.
Journal of medicinal chemistry 2005;48(20):6409-22.
2005: Sylvie D Barchéchath; Rommel I Tawatao; Maripat Corr; Dennis A Carson; Howard B Cottam
Quinolinium salt as a potent inhibitor of lymphocyte apoptosis.
Bioorganic & medicinal chemistry letters 2005;15(7):1785-8.
2005: Siva Kumar Kolluri; Maripat Corr; Sharon Y James; Michele Bernasconi; Desheng Lu; Wen Liu; Howard B Cottam; Lorenzo Leoni; Dennis A Carson; Xiao-kun Zhang
The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2525-30.
2005: Junko Ohata; Nathan J Zvaifler; Mitsufumi Nishio; David L Boyle; Susan L Kalled; Dennis A Carson; Thomas Kipps
Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):864-70.
2004: Mitchell B Diccianni; John Yu; Gerda Meppelink; Marten de Vries; Lien Shao; Sigrun Gebauer; Hsien Shih; William Roberts; Neil P Kilcoin; Jeanette Pullen; Dennis A Carson; Alice L Yu
3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner.
Journal of experimental therapeutics & oncology 2004;4(3):223-37.
2004: Christina C N Wu; Jongdae Lee; Eyal Raz; Maripat Corr; Dennis A Carson
Necessity of oligonucleotide aggregation for toll-like receptor 9 activation.
The Journal of biological chemistry 2004;279(32):33071-8.
2004: Tomoko Hayashi; Lucinda Beck; Cyprian Rossetto; Xing Gong; Osamu Takikawa; Kenji Takabayashi; David H Broide; Dennis A Carson; Eyal Raz
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase.
The Journal of clinical investigation 2004;114(2):270-9.
2004: Michael Hedvat; Anjali Jain; Dennis A Carson; Lorenzo Leoni; Ganghua Huang; Stuart Holden; Desheng Lu; Maripat Corr; William D Fox; David B Agus
Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma.
Cancer cell 2004;5(6):565-74.
2004: Desheng Lu; Yandong Zhao; Rommel I Tawatao; Howard B Cottam; Malini Sen; Lorenzo Leoni; Thomas Kipps; Maripat Corr; Dennis A Carson
Activation of the Wnt signaling pathway in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3118-23.
2004: Souichi Adachi; Lorenzo Leoni; Dennis A Carson; Tatsutoshi Nakahata
Apoptosis induced by molecular targeting therapy in hematological malignancies.
Acta haematologica 2004;111(1-2):107-23.
2003: Christina C N Wu; Januario E Castro; Marina Motta; Howard B Cottam; Diego Kyburz; Thomas Kipps; Maripat Corr; Dennis A Carson
Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells.
Human gene therapy 2003;14(9):849-60.
2003: Jongdae Lee; Tsung-Hsien Chuang; Vanessa Redecke; Liping She; PAULA PITHA-ROWE; Dennis A Carson; Eyal Raz; Howard B Cottam
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6646-51.
2003: Dennis A Carson; Lorenzo Leoni
Hairy-cell leukaemia as a model for drug development.
Best practice & research. Clinical haematology 2003;16(1):83-9.
2003: Diego Kyburz; Janine Rethage; Reinhart Seibl; Roger Lauener; Renate E Gay; Dennis A Carson; Steffen Gay
Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling.
Arthritis and rheumatism 2003;48(3):642-50.
2002: Malini Sen; Jack Reifert; Kevin Lauterbach; Vladimir Wolf; Jeffrey S Rubin; Maripat Corr; Dennis A Carson
Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes.
Arthritis and rheumatism 2002;46(11):2867-77.
2002: Chae-Seo Rhee; Malini Sen; Desheng Lu; Christina Wu; Lorenzo Leoni; Jeffrey Rubin; Maripat Corr; Dennis A Carson
Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas.
Oncogene 2002;21(43):6598-605.
2002: Hsiencheng Shih; Howard B Cottam; Dennis A Carson
Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors.
Chemical & pharmaceutical bulletin 2002;50(3):364-7.
2002: Arash Ronaghy; Berent J Prakken; Kenji Takabayashi; Gary S Firestein; David Boyle; Nathan J Zvailfler; Sarah Roord; Salvatore Albani; Dennis A Carson; Eyal Raz
Immunostimulatory DNA sequences influence the course of adjuvant arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):51-6.
2001: John Henry Van Uden; C H Tran; Dennis A Carson; Eyal Raz
Type I interferon is required to mount an adaptive response to immunostimulatory DNA.
European journal of immunology 2001;31(11):3281-90.
2001: XH Hua; Davide Genini; R Gussio; Rommel I Tawatao; Hsiencheng Shih; Thomas Kipps; Dennis A Carson; Lorenzo Leoni
Biochemical genetic analysis of indanocine resistance in human leukemia.
Cancer research 2001;61(19):7248-54.
2001: Tomoko Hayashi; S P Rao; Kenji Takabayashi; John Henry Van Uden; Richard Kornbluth; S M Baird; Milton Taylor; Dennis A Carson; A Catanzaro; Eyal Raz
Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase.
Infection and immunity 2001;69(10):6156-64.
2001: Malini Sen; M Chamorro; Jack Reifert; Maripat Corr; Dennis A Carson
Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation.
Arthritis and rheumatism 2001;44(4):772-81.
2001: Davide Genini; Dennis Sheeter; Steffney Rought; John J Zaunders; S A Susin; G Kroemer; Douglas D Richman; Dennis A Carson; Jacques Corbeil; Lorenzo Leoni
HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):5-6.
2000: M Schmid; M Sen; MD Rosenbach; CJ Carrera; H Friedman; Dennis A Carson
A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.
Oncogene 2000;19(50):5747-54.
2000: Davide Genini; S Adachi; Q Chao; David Rose; CJ Carrera; Howard B Cottam; Dennis A Carson; Lorenzo Leoni
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria.
Blood 2000;96(10):3537-43.
2000: Diego Kyburz; Dennis A Carson; Maripat Corr
The role of CD40 ligand and tumor necrosis factor alpha signaling in the transgenic K/BxN mouse model of rheumatoid arthritis.
Arthritis and rheumatism 2000;43(11):2571-7.
2000: Malini Sen; K Lauterbach; H El-Gabalawy; Gary S Firestein; Maripat Corr; Dennis A Carson
Expression and function of wingless and frizzled homologs in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2791-6.
2000: Hsiencheng Shih; L Deng; CJ Carrera; S Adachi; Howard B Cottam; Dennis A Carson
Rational design, synthesis and structure-activity relationships of antitumor (E)-2-benzylidene-1-tetralones and (E)-2-benzylidene-1-indanones.
Bioorganic & medicinal chemistry letters 2000;10(5):487-90.
2000: Lorenzo Leoni; Ernest Hamel; Davide Genini; Hsiencheng Shih; CJ Carrera; Howard B Cottam; Dennis A Carson
Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells.
Journal of the National Cancer Institute 2000;92(3):217-24.
2000: Davide Genini; I Budihardjo; W Plunkett; X Wang; CJ Carrera; Howard B Cottam; Dennis A Carson; Lorenzo Leoni
Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway.
The Journal of biological chemistry 2000;275(1):29-34.
1999: Dustan Bonnin; Berent J Prakken; Rodrigo Samodal; Antonio La Cava; Dennis A Carson; Salvatore Albani
Ontogeny of synonymous T cell populations with specificity for a self MHC epitope mimicked by a bacterial homologoue: an antigen-specific T cell analysis in a non-transgenic system.
European journal of immunology 1999;29(12):3826-36.
1999: Q Chao; L Deng; Hsiencheng Shih; Lorenzo Leoni; Davide Genini; Dennis A Carson; Howard B Cottam
Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.
Journal of medicinal chemistry 1999;42(19):3860-73.
1999: Diego Kyburz; Maripat Corr; Diana C Brinson; A Von Damm; Helen Tighe; Dennis A Carson
Human rheumatoid factor production is dependent on CD40 signaling and autoantigen.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3116-22.
1999: Reginald U Chukwuocha; B Zhang; C J Lai; John Scavulli; Salvatore Albani; Dennis A Carson; Pojen P Chen
Isolation of an IgG monoclonal anti-dnaJ antibody from an immunoglobulin combinatorial library from a patient with rheumatoid arthritis.
The Journal of rheumatology 1999;26(7):1439-45.
1999: K Warnatz; Diego Kyburz; Diana C Brinson; D J Lee; A Von Damm; M Engelhart; Maripat Corr; Dennis A Carson; Helen Tighe
Rheumatoid factor B cell tolerance via autonomous Fas/FasL-independent apoptosis.
Cellular immunology 1999;191(1):69-73.
1998: M Schmid; Denise M Malicki; T Nobori; MD Rosenbach; K Campbell; Dennis A Carson; CJ Carrera
Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC).
Oncogene 1998;17(20):2669-75.
1998: D J Lee; Maripat Corr; Dennis A Carson
Control of immune responses by gene immunization.
Annals of medicine 1998;30(5):460-8.
1998: Lorenzo Leoni; Q Chao; Howard B Cottam; Davide Genini; MD Rosenbach; CJ Carrera; I Budihardjo; X Wang; Dennis A Carson
Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9567-71.
1998: Dennis A Carson
An infectious origin of extraskeletal calcification.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):7846-7.
1998: Lorenzo Leoni; H C Shih; L Deng; C Tuey; G Walter; Dennis A Carson; Howard B Cottam
Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds.
Biochemical pharmacology 1998;55(7):1105-11.
1998: Y Hori; H Hori; Y Yamada; CJ Carrera; M Tomonaga; S Kamihira; Dennis A Carson; T Nobori
The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia.
International journal of cancer. Journal international du cancer 1998;75(1):51-6.
1997: Dennis A Carson; E Raz
Oligonucleotide adjuvants for T helper 1 (Th1)-specific vaccination.
The Journal of experimental medicine 1997;186(10):1621-2.
1997: Maripat Corr; Helen Tighe; D Lee; J Dudler; May Trieu; Diana C Brinson; Dennis A Carson
Costimulation provided by DNA immunization enhances antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4999-5004.
1997: C S Cho; X Wang; Y Zhao; Dennis A Carson; Pojen P Chen
Genotyping by PCR-ELISA of a complex polymorphic region that contains one to four copies of six highly homologous human VH3 genes.
Proceedings of the Association of American Physicians 1997;109(6):558-64.
1997: Antonio La Cava; J L Nelson; W E Ollier; A MacGregor; E C Keystone; J C Thorne; John Scavulli; C C Berry; Dennis A Carson; Salvatore Albani
Genetic bias in immune responses to a cassette shared by different microorganisms in patients with rheumatoid arthritis.
The Journal of clinical investigation 1997;100(3):658-63.
1997: D J Lee; Helen Tighe; Maripat Corr; Mark Roman; Dennis A Carson; Hans L Spiegelberg; Eyal Raz
Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells.
International archives of allergy and immunology 1997;113(1-3):227-30.
1997: Phuoc Tran; H Hori; Y Hori; K Okumura; K Kagotani; H Taguchi; Dennis A Carson; T Nobori
Molecular cloning of the human methylthioadenosine phosphorylase processed pseudogene and localization to 3q28.
Gene 1997;186(2):263-9.
1997: Helen Tighe; K Warnatz; Diana C Brinson; Maripat Corr; W O Weigle; S M Baird; Dennis A Carson
Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):646-51.
1997: Y Y Yang; P Fischer; S J Leu; T Olee; Dennis A Carson; Pojen P Chen
IgG rheumatoid factors isolated by the surface-displaying phage library technique.
Immunogenetics 1997;45(5):301-10.
1996: H Kohsaka; Dennis A Carson; Laura Rassenti; W E Ollier; Pojen P Chen; Thomas Kipps; N Miyasaka
The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation.
The Journal of clinical investigation 1996;98(12):2794-800.
1996: H Hori; Phuoc Tran; CJ Carrera; Y Hori; M D Rosenbach; Dennis A Carson; T Nobori
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
Cancer research 1996;56(24):5653-8.
1996: Maripat Corr; D J Lee; Dennis A Carson; Helen Tighe
Gene vaccination with naked plasmid DNA: mechanism of CTL priming.
The Journal of experimental medicine 1996;184(4):1555-60.
1996: Y Sato; Mark Roman; Helen Tighe; D Lee; Maripat Corr; MD Nguyen; Gregg J Silverman; Martin Lotz; Dennis A Carson; Eyal Raz
Immunostimulatory DNA sequences necessary for effective intradermal gene immunization.
Science (New York, N.Y.) 1996;273(5273):352-4.
1996: T Nobori; K Takabayashi; Phuoc Tran; L Orvis; Ayse Batova; Alice L Yu; Dennis A Carson
Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):6203-8.
1996: Eyal Raz; Helen Tighe; Y Sato; Maripat Corr; J A Dudler; Mark Roman; S L Swain; Hans L Spiegelberg; Dennis A Carson
Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):5141-5.
1996: H Hori; K Takabayashi; L Orvis; Dennis A Carson; T Nobori
Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase.
Cancer research 1996;56(9):2116-22.
1996: Howard B Cottam; H Shih; L R Tehrani; D B Wasson; Dennis A Carson
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.
Journal of medicinal chemistry 1996;39(1):2-9.
1995: B Eibschutz; S M Baird; M H Weisman; D G Amox; M Spellman; D Piacquadio; CJ Carrera; Dennis A Carson
Oral 2-chlorodeoxyadenosine in psoriatic arthritis. A preliminary report.
Arthritis and rheumatism 1995;38(11):1604-9.
1995: Dennis A Carson; A Lois
Cancer progression and p53.
Lancet 1995;346(8981):1009-11.
1995: Eyal Raz; J Dudler; Martin Lotz; S M Baird; C C Berry; R A Eisenberg; Dennis A Carson
Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery.
Lupus 1995;4(4):286-92.
1995: Salvatore Albani; E C Keystone; J L Nelson; W E Ollier; Antonio La Cava; A C Montemayor; D A Weber; C Montecucco; A Martini; Dennis A Carson
Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis.
Nature medicine 1995;1(5):448-52.
1995: D F Huang; Katherine A Siminovitch; X Y Liu; T Olee; N J Olsen; C Berry; Dennis A Carson; Pojen P Chen
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus.
The Journal of clinical investigation 1995;95(4):1766-72.
1995: Ian P Wicks; M L Howell; T Hancock; H Kohsaka; T Olee; Dennis A Carson
Bacterial lipopolysaccharide copurifies with plasmid DNA: implications for animal models and human gene therapy.
Human gene therapy 1995;6(3):317-23.
1995: Dennis A Carson; E M Tan
Apoptosis in rheumatic disease.
Bulletin on the rheumatic diseases 1995;44(1):1-3.
1995: Helen Tighe; P Heaphy; S Baird; W O Weigle; Dennis A Carson
Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice.
The Journal of experimental medicine 1995;181(2):599-606.
1994: Eyal Raz; Dennis A Carson; SE Parker; T B Parr; Anna Maria Abai; G Aichinger; S H Gromkowski; M Singh; D Lew; M A Yankauckas
Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9519-23.
1994: M Deftos; T Olee; Dennis A Carson; Pojen P Chen
Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.
The Journal of clinical investigation 1994;93(6):2545-53.
1994: T Nobori; K Miura; D J Wu; A Lois; K Takabayashi; Dennis A Carson
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.
Nature 1994;368(6473):753-6.
1994: Salvatore Albani; Angelo Ravelli; M Massa; de benedetti fabrizio; G Andree; Jean Roudier; A Martini; Dennis A Carson
Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity.
The Journal of pediatrics 1994;124(4):561-5.
1994: A Taniguchi; H Kohsaka; Dennis A Carson
Competitive RT-PCR ELISA: a rapid, sensitive and non-radioactive method to quantitate cytokine mRNA.
Journal of immunological methods 1994;169(1):101-9.
1994: H Kohsaka; Dennis A Carson
Solid-phase polymerase chain reaction.
Journal of clinical laboratory analysis 1994;8(6):452-5.
1993: R Kobayashi; Laura Rassenti; Grant Meisenholder; Dennis A Carson; Thomas Kipps
Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):7273-83.
1993: Howard B Cottam; D B Wasson; H C Shih; A Raychaudhuri; G Di Pasquale; Dennis A Carson
New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation.
Journal of medicinal chemistry 1993;36(22):3424-30.
1993: A Watanabe; Eyal Raz; H Kohsaka; Helen Tighe; S M Baird; Thomas Kipps; Dennis A Carson
Induction of antibodies to a kappa V region by gene immunization.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2871-6.
1993: H Kohsaka; A Taniguchi; Pojen P Chen; W E Ollier; Dennis A Carson
The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: rapid analysis by anchored polymerase chain reaction and enzyme-linked immunosorbent assay.
European journal of immunology 1993;23(8):1895-901.
1993: H Kohsaka; A Taniguchi; Douglas D Richman; Dennis A Carson
Microtiter format gene quantification by covalent capture of competitive PCR products: application to HIV-1 detection.
Nucleic acids research 1993;21(15):3469-72.
1993: E W Lu; M Deftos; T Olee; D F Huang; R W Soto-Gil; Dennis A Carson; Pojen P Chen
Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors.
Arthritis and rheumatism 1993;36(7):927-37.
1993: Eyal Raz; A Watanabe; S M Baird; R A Eisenberg; T B Parr; Martin Lotz; Thomas Kipps; Dennis A Carson
Systemic immunological effects of cytokine genes injected into skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4523-7.
1993: Thomas Kipps; Dennis A Carson
Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases.
Blood 1993;81(10):2475-87.
1993: Dennis A Carson; J M Ribeiro
Apoptosis and disease.
Lancet 1993;341(8855):1251-4.
1993: Klaus Machold; Dennis A Carson; Martin Lotz
Transforming growth factor-beta (TGF beta) inhibition of Epstein-Barr virus (EBV)- and interleukin-4 (IL-4)-induced immunoglobulin production in human B lymphocytes.
Journal of clinical immunology 1993;13(3):219-27.
1993: P M Yang; T Olee; Dennis A Carson; Pojen P Chen
Characterization of two highly homologous autoantibody-related VH1 genes in humans.
Scandinavian journal of immunology 1993;37(4):504-8.
1993: T Nobori; I Szinai; D Amox; B Parker; Olufunmilayo I Olopade; D L Buchhagen; Dennis A Carson
Methylthioadenosine phosphorylase deficiency in human non-small cell lung cancers.
Cancer research 1993;53(5):1098-101.
1993: H Kohsaka; Pojen P Chen; A Taniguchi; W E Ollier; Dennis A Carson
Divergent T cell receptor gamma repertoires in rheumatoid arthritis monozygotic twins.
Arthritis and rheumatism 1993;36(2):213-21.
1993: H Kawasaki; CJ Carrera; Lawrence D Piro; Alan Saven; Thomas Kipps; Dennis A Carson
Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine.
Blood 1993;81(3):597-601.
1993: Helen Tighe; Pojen P Chen; R Tucker; Thomas Kipps; Jean Roudier; F R Jirik; Dennis A Carson
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice.
The Journal of experimental medicine 1993;177(1):109-18.
1993: E Beutler; Dennis A Carson
2-Chlorodeoxyadenosine: hairy cell leukemia takes a surprising turn.
Blood cells 1993;19(3):559-68; discussion 569-72.
1993: H Kohsaka; Pojen P Chen; A Taniguchi; W E Ollier; Dennis A Carson
Regulation of the mature human T cell receptor gamma repertoire by biased V-J gene rearrangement.
The Journal of clinical investigation 1993;91(1):171-8.
1992: D F Huang; T Olee; Y Masuho; Y Matsumoto; Dennis A Carson; Pojen P Chen
Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes.
The Journal of clinical investigation 1992;90(6):2197-208.
1992: H Kawasaki; CJ Carrera; Dennis A Carson
Quantitative immunoassay of human deoxycytidine kinase in malignant cells.
Analytical biochemistry 1992;207(1):193-6.
1992: Salvatore Albani; Dennis A Carson; Jean Roudier
Genetic and environmental factors in the immune pathogenesis of rheumatoid arthritis.
Rheumatic diseases clinics of North America 1992;18(4):729-40.
1992: R Kobayashi; Gastón R Picchio; M Kirven; Grant Meisenholder; S Baird; Dennis A Carson; Donald E Mosier; Thomas Kipps
Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency.
Leukemia research 1992;16(10):1013-23.
1992: T Nobori; L Reynolds; L Orvis; D Wu; Dennis A Carson
A polymerase chain reaction-based method for isolation of gene-specific sequences from the interferon-alpha gene cluster.
Analytical biochemistry 1992;205(1):42-6.
1992: Dennis A Carson
Genetic factors in the etiology and pathogenesis of autoimmunity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(10):2800-5.
1992: Thomas Kipps; Laura Rassenti; S Duffy; T Johnson; R Kobayashi; Dennis A Carson
Immunoglobulin V gene expression in CD5 B-cell malignancies.
Annals of the New York Academy of Sciences 1992;651():373-83.
1992: Dennis A Carson; D B Wasson; L M Esparza; CJ Carrera; Thomas Kipps; Howard B Cottam
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2970-4.
1992: T Olee; E W Lu; D F Huang; R W Soto-Gil; M Deftos; F Kozin; Dennis A Carson; Pojen P Chen
Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response.
The Journal of experimental medicine 1992;175(3):831-42.
1992: R W Soto-Gil; T Olee; B K Klink; Thomas P Kenny; Dick L Robbins; Dennis A Carson; Pojen P Chen
A systematic approach to defining the germline gene counterparts of a mutated autoantibody from a patient with rheumatoid arthritis.
Arthritis and rheumatism 1992;35(3):356-63.
1992: E W Lu; M Deftos; Helen Tighe; Dennis A Carson; Pojen P Chen
Generation and characterization of two monoclonal self-associating IgG rheumatoid factors from a rheumatoid synovium.
Arthritis and rheumatism 1992;35(1):101-5.
1992: Salvatore Albani; J E Tuckwell; L Esparza; Dennis A Carson; Jean Roudier
The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.
The Journal of clinical investigation 1992;89(1):327-31.
1991: C Terai; D B Wasson; CJ Carrera; Dennis A Carson
Dependence of cell survival on DNA repair in human mononuclear phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(12):4302-6.
1991: P M Yang; J J Crowley; D O McDaniel; W J Koopman; F Kozin; Dennis A Carson; Pojen P Chen
Genetic studies of four highly homologous rheumatoid factor-associated Vk genes in rheumatoid arthritis patients and normal individuals.
Molecular immunology 1991;28(10):1073-83.
1991: Jean Roudier; Salvatore Albani; Dennis A Carson
Immune response to peptides from the third hypervariable region of the beta chain of MHC class II molecules. Implications for the immune response to foreign antigens.
Seminars in cancer biology 1991;2(5):283-5.
1991: L F Pratt; R Szubin; Dennis A Carson; Thomas Kipps
Molecular characterization of a supratypic cross-reactive idiotype associated with IgM autoantibodies.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):2041-6.
1991: Jean Roudier; A Sette; A Lamont; Salvatore Albani; J G Karras; Dennis A Carson
Tolerance to a self peptide from the third hypervariable region of the Es beta chain. Implications for molecular mimicry models of autoimmune disease.
European journal of immunology 1991;21(9):2063-7.
1991: Laura Rassenti; L F Pratt; Pojen P Chen; Dennis A Carson; Thomas Kipps
Autoantibody-encoding kappa L chain genes frequently rearranged in lambda L chain-expressing chronic lymphocytic leukemia.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):1060-6.
1991: T Nobori; L E Hexdall; Dennis A Carson
A polymorphic region defined by pCN2 (the 3' nontranslated region of N-ras) maps to chromosome 9cen-p12.
Human genetics 1991;87(4):433-7.
1991: T Olee; P M Yang; Katherine A Siminovitch; N J Olsen; J Hillson; J Wu; F Kozin; Dennis A Carson; Pojen P Chen
Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases.
The Journal of clinical investigation 1991;88(1):193-203.
1991: Karl Y Hostetler; Dennis A Carson; Douglas D Richman
Phosphatidylazidothymidine. Mechanism of antiretroviral action in CEM cells.
The Journal of biological chemistry 1991;266(18):11714-7.
1991: T Nobori; J G Karras; F Della Ragione; T A Waltz; P P Chen; Dennis A Carson
Absence of methylthioadenosine phosphorylase in human gliomas.
Cancer research 1991;51(12):3193-7.
1991: C Terai; Richard Kornbluth; C. David Pauza; Douglas D Richman; Dennis A Carson
Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.
The Journal of clinical investigation 1991;87(5):1710-5.
1991: O Axelrod; Gregg J Silverman; V Dev; R Kyle; Dennis A Carson; Thomas Kipps
Idiotypic cross-reactivity of immunoglobulins expressed in Waldenström's macroglobulinemia, chronic lymphocytic leukemia, and mantle zone lymphocytes of secondary B-cell follicles.
Blood 1991;77(7):1484-90.
1991: J Kekow; W Wachsman; J A McCutchan; W L Gross; M Zachariah; Dennis A Carson; Martin Lotz
Transforming growth factor-beta and suppression of humoral immune responses in HIV infection.
The Journal of clinical investigation 1991;87(3):1010-6.
1991: Dennis A Carson; Pojen P Chen; Thomas Kipps
New roles for rheumatoid factor.
The Journal of clinical investigation 1991;87(2):379-83.
1991: Dennis A Carson; CJ Carrera; D B Wasson; T Iizasa
Deoxyadenosine-resistant human T lymphoblasts with elevated 5'-nucleotidase activity.
Biochimica et biophysica acta 1991;1091(1):22-8.
1991: Dennis A Carson; Pojen P Chen; Gregg J Silverman; Thomas Kipps
Immunoglobulin gene expression in systemic rheumatic diseases.
British journal of rheumatology 1991;30 Suppl 1():43-6.
1991: Dennis A Carson
The specificity of anti-DNA antibodies in systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(1):1-2.
1991: D J Wu; L Reynolds; Dennis A Carson; T Nobori
Molecular genetic analysis of chromosome 9p in methylthioadenosine phosphorylase deficient glioma cell lines.
Advances in experimental medicine and biology 1991;309B():207-11.
1991: CJ Carrera; Lawrence D Piro; Alan Saven; E Beutler; C Terai; Dennis A Carson
2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes.
Advances in experimental medicine and biology 1991;309A():15-8.
1990: CJ Carrera; C Terai; Martin Lotz; J G Curd; Lawrence D Piro; E Beutler; Dennis A Carson
Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy.
The Journal of clinical investigation 1990;86(5):1480-8.
1990: J Kekow; W Wachsman; J A McCutchan; M Cronin; Dennis A Carson; Martin Lotz
Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8321-5.
1990: P M Yang; N J Olsen; Katherine A Siminovitch; T Olee; F Kozin; Dennis A Carson; Pojen P Chen
Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7907-11.
1990: Gregg J Silverman; R E Schrohenloher; M A Accavitti; William J Koopman; Dennis A Carson
Structural characterization of the second major cross-reactive idiotype group of human rheumatoid factors. Association with the VH4 gene family.
Arthritis and rheumatism 1990;33(9):1347-60.
1990: Dennis A Carson; CJ Carrera
Immunodeficiency secondary to adenosine deaminase deficiency and purine nucleoside phosphorylation deficiency.
Seminars in hematology 1990;27(3):260-9.
1990: Martin Lotz; J Kekow; Dennis A Carson
Transforming growth factor-beta and cellular immune responses in synovial fluids.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(11):4189-94.
1990: Pojen P Chen; R W Soto-Gil; Dennis A Carson
The early expression of some human autoantibody-associated heavy chain variable region genes is controlled by specific regulatory elements.
Scandinavian journal of immunology 1990;31(6):673-8.
1990: Lawrence D Piro; CJ Carrera; Dennis A Carson; E Beutler
Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine.
The New England journal of medicine 1990;322(16):1117-21.
1990: Thomas Kipps; B A Robbins; A Tefferi; Grant Meisenholder; P M Banks; Dennis A Carson
CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies.
The American journal of pathology 1990;136(4):809-16.
1990: Jean Roudier; Gregg J Silverman; Pojen P Chen; Dennis A Carson; Thomas Kipps
Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1526-30.
1990: Gregg J Silverman; Dennis A Carson
Structural characterization of human monoclonal cold agglutinins: evidence for a distinct primary sequence-defined VH4 idiotype.
European journal of immunology 1990;20(2):351-6.
1990: P A Guerne; Dennis A Carson; Martin Lotz
IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):499-505.
1990: P P Chen; Gregg J Silverman; M F Liu; Dennis A Carson
Idiotypic and molecular characterization of human rheumatoid factors.
Chemical immunology 1990;48():63-81.
1990: Pojen P Chen; N J Olsen; P M Yang; R W Soto-Gil; T Olee; Katherine A Siminovitch; Dennis A Carson
From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all.
International reviews of immunology 1990;5(3-4):239-51.
1990: J J Crowley; R A Mageed; Gregg J Silverman; Pojen P Chen; F Kozin; R A Erger; R Jefferis; Dennis A Carson
The incidence of a new human cross-reactive idiotype linked to subgroup VHIII heavy chains.
Molecular immunology 1990;27(1):87-94.
1990: Thomas Kipps; B A Robbins; Dennis A Carson
Uniform high frequency expression of autoantibody-associated crossreactive idiotypes in the primary B cell follicles of human fetal spleen.
The Journal of experimental medicine 1990;171(1):189-96.
1990: Gregg J Silverman; P P Chen; Dennis A Carson
Cold agglutinins: specificity, idiotypy and structural analysis.
Chemical immunology 1990;48():109-25.
1989: T Nobori; H Yamanaka; Dennis A Carson
Poly(ADP-ribose) polymerase inhibits DNA synthesis initiation in the absence of NAD.
Biochemical and biophysical research communications 1989;163(2):1113-8.
1989: T Nobori; L E Hexdall; Dennis A Carson
cDNA sequence of human ribosomal protein L31.
Nucleic acids research 1989;17(17):7105.
1989: Dennis A Carson; Pojen P Chen; Thomas Kipps; Jean Roudier; Gregg J Silverman; Helen Tighe
Regulation of rheumatoid factor synthesis.
Clinical and experimental rheumatology 1989;7 Suppl 3():S69-73.
1989: Pojen P Chen; Katherine A Siminovitch; N J Olsen; R A Erger; Dennis A Carson
A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes.
The Journal of clinical investigation 1989;84(2):706-10.
1989: Thomas Kipps; E Tomhave; L F Pratt; S Duffy; Pojen P Chen; Dennis A Carson
Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5913-7.
1989: P A Guerne; Bruce L Zuraw; J H Vaughan; Dennis A Carson; M Lotz
Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.
The Journal of clinical investigation 1989;83(2):585-92.
1989: M F Liu; D L Robbins; J J Crowley; S Sinha; F Kozin; Thomas Kipps; Dennis A Carson; Pojen P Chen
Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):688-94.
1989: F R Jirik; T J Podor; T Hirano; T Kishimoto; D J Loskutoff; Dennis A Carson; M Lotz
Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):144-7.
1989: Dennis A Carson; T Haertle; CJ Carrera; Erik Willis; D B Wasson; D D Richman
2-halo-2',3'-dideoxyadenosines: metabolically stable dideoxynucleosides with activity against the human immunodeficiency virus (HIV).
Advances in experimental medicine and biology 1989;253B():395-8.
1989: Dennis A Carson; Lawrence D Piro; D B Wasson; CJ Carrera; E Beutler
Activity of 2-chloro-2'-deoxyadenosine in chronic lymphocytic leukemia, hairy cell leukemia, and autoimmune hemolytic anemia.
Advances in experimental medicine and biology 1989;253A():427-31.
1989: CJ Carrera; H Yamanaka; Lawrence D Piro; M Lotz; Dennis A Carson
Profound toxicity of deoxyadenosine and 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo.
Advances in experimental medicine and biology 1989;253B():219-25.
1989: H Yamanaka; C A Penning; Erik Willis; D B Wasson; Dennis A Carson
Characterization of poly(ADP-ribose) polymerase with human autoantibodies.
Advances in experimental medicine and biology 1989;253B():259-65.
1989: D B Wasson; H Yamanaka; Dennis A Carson
Utilization of 2'-deoxynad for ADP-ribose transfer reactions.
Advances in experimental medicine and biology 1989;253B():213-8.
1989: H Yamanaka; E Olavi; M Kubota; D B Wasson; Erik Willis; Dennis A Carson
Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells.
Advances in experimental medicine and biology 1989;253B():193-9.
1989: P P Chen; M F Liu; C A Glass; S Sinha; T J Kipps; Dennis A Carson
Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors.
Arthritis and rheumatism 1989;32(1):72-6.
1989: H Yamanaka; Erik Willis; Dennis A Carson
Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase recognize cross-reactive epitopes associated with the catalytic site of the enzyme.
The Journal of clinical investigation 1989;83(1):180-6.
1988: Gregg J Silverman; F Goñi; J Fernandez; P P Chen; Blas Frangione; Dennis A Carson
Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity.
The Journal of experimental medicine 1988;168(6):2361-6.
1988: P P Chen; M F Liu; S Sinha; Dennis A Carson
A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation.
Arthritis and rheumatism 1988;31(11):1429-31.
1988: Dennis A Carson; D B Wasson
Synthesis of 2',3'-dideoxynucleosides by enzymatic trans-glycosylation.
Biochemical and biophysical research communications 1988;155(2):829-34.
1988: M Lotz; J H Vaughan; Dennis A Carson
Effect of neuropeptides on production of inflammatory cytokines by human monocytes.
Science (New York, N.Y.) 1988;241(4870):1218-21.
1988: Lawrence D Piro; CJ Carrera; E Beutler; Dennis A Carson
2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia.
Blood 1988;72(3):1069-73.
1988: T J Kipps; B A Robbins; P Kuster; Dennis A Carson
Autoantibody-associated cross-reactive idiotypes expressed at high frequency in chronic lymphocytic leukemia relative to B-cell lymphomas of follicular center cell origin.
Blood 1988;72(2):422-8.
1988: Gregg J Silverman; R D Goldfien; P Chen; R A Mageed; R Jefferis; F Goñi; Blas Frangione; S Fong; Dennis A Carson
Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans.
The Journal of clinical investigation 1988;82(2):469-75.
1988: J J Crowley; R D Goldfien; R E Schrohenloher; H L Spiegelberg; Gregg J Silverman; R A Mageed; R Jefferis; William J Koopman; Dennis A Carson; S Fong
Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(10):3411-8.
1988: T Haertle; CJ Carrera; D B Wasson; L C Sowers; D D Richman; Dennis A Carson
Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2',3'-dideoxyadenosine derivatives.
The Journal of biological chemistry 1988;263(12):5870-5.
1988: Jean Roudier; Gary H Rhodes; J Petersen; J H Vaughan; Dennis A Carson
The Epstein-Barr virus glycoprotein gp110, a molecular link between HLA DR4, HLA DR1, and rheumatoid arthritis.
Scandinavian journal of immunology 1988;27(4):367-71.
1988: Dennis A Carson; T Haertle; D B Wasson; D D Richman
Biochemical genetic analysis of 2',3'-dideoxyadenosine metabolism in human T lymphocytes.
Biochemical and biophysical research communications 1988;151(2):788-93.
1988: H Yamanaka; C A Penning; Erik Willis; D B Wasson; Dennis A Carson
Characterization of human poly(ADP-ribose) polymerase with autoantibodies.
The Journal of biological chemistry 1988;263(8):3879-83.
1988: Thomas Kipps; E Tomhave; Pojen P Chen; Dennis A Carson
Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.
The Journal of experimental medicine 1988;167(3):840-52.
1988: M Lotz; F Jirik; P Kabouridis; C Tsoukas; T Hirano; T Kishimoto; Dennis A Carson
B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.
The Journal of experimental medicine 1988;167(3):1253-8.
1988: S Fong; Pojen P Chen; R I Fox; R D Goldfien; V Radoux; Gregg J Silverman; J J Crowley; Jean Roudier; Dennis A Carson
The diversity and idiotypic patterns of human rheumatoid factors in disease.
Concepts in immunopathology 1988;5():168-91.
1988: Dennis A Carson; T Nobori; E O Kajander; CJ Carrera; M Kubota; H Yamanaka
Methylthioadenosine (MeSAdo) phosphorylase deficiency in malignancy.
Advances in experimental medicine and biology 1988;250():179-85.
1988: S Fong; P P Chen; J J Crowley; Gregg J Silverman; Dennis A Carson
Idiotypic characteristics of rheumatoid factors.
Scandinavian journal of rheumatology. Supplement 1988;75():58-65.
1988: S Fong; P P Chen; J J Crowley; Gregg J Silverman; Dennis A Carson
Idiotypes and the structural diversity of human rheumatoid factors.
Springer seminars in immunopathology 1988;10(2-3):189-201.
1988: P P Chen; S Fong; F Goni; Gregg J Silverman; R I Fox; M F Liu; Blas Frangione; Dennis A Carson
Cross-reacting idiotypes on cryoprecipitating rheumatoid factor.
Springer seminars in immunopathology 1988;10(1):35-55.
1988: Dennis A Carson; CJ Carrera; D B Wasson; H Yamanaka
Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes.
Advances in enzyme regulation 1988;27():395-404.
1987: P P Chen; S Fong; Dennis A Carson
Rheumatoid factor.
Rheumatic diseases clinics of North America 1987;13(3):545-68.
1987: Dennis A Carson; Pojen P Chen; Thomas Kipps; V Radoux; F R Jirik; R D Goldfien; R I Fox; Gregg J Silverman; S Fong
Idiotypic and genetic studies of human rheumatoid factors.
Arthritis and rheumatism 1987;30(12):1321-5.
1987: P P Chen; D L Robbins; F R Jirik; T J Kipps; Dennis A Carson
Isolation and characterization of a light chain variable region gene for human rheumatoid factors.
The Journal of experimental medicine 1987;166(6):1900-5.
1987: Pojen P Chen; K Albrandt; Thomas Kipps; V Radoux; Fu-Tong Liu; Dennis A Carson
Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(5):1727-33.
1987: H Yamanaka; Erik Willis; C A Penning; C L Peebles; E M Tan; Dennis A Carson
Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase.
The Journal of clinical investigation 1987;80(3):900-4.
1987: Pojen P Chen; S Fong; Dennis A Carson
The use of defined peptides in characterizing idiotypes.
International reviews of immunology 1987;2(4):419-32.
1987: Thomas Kipps; S Fong; E Tomhave; Pojen P Chen; R D Goldfien; Dennis A Carson
High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):2916-20.
1987: R D Goldfien; P J Chen; Thomas Kipps; G Starkebaum; J G Heitzmann; V Radoux; S Fong; Dennis A Carson
Genetic analysis of human B cell hybridomas expressing a cross-reactive idiotype.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(3):940-4.
1987: Pojen P Chen; S Fong; F Goni; R A Houghten; Blas Frangione; Fu-Tong Liu; Dennis A Carson
Analyses of human rheumatoid factors with anti-idiotypes induced by synthetic peptides.
Monographs in allergy 1987;22():12-23.
1987: Dennis A Carson; Pojen P Chen; Thomas Kipps; V Radoux; F Jirik; R D Goldfien; R I Fox; Gregg J Silverman; S Fong
Molecular basis for the cross-reactive idiotypes on human anti-IgG autoantibodies (rheumatoid factors).
Ciba Foundation symposium 1987;129():123-34.
1987: Dennis A Carson; Pojen P Chen; R I Fox; Thomas Kipps; F Jirik; R D Goldfien; G Silverman; V Radoux; S Fong
Rheumatoid factor and immune networks.
Annual review of immunology 1987;5():109-26.
1986: Pojen P Chen; K Albrandt; N K Orida; V Radoux; E Y Chen; R Schrantz; Fu-Tong Liu; Dennis A Carson
Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8318-22.
1986: F R Jirik; J Sorge; S Fong; J G Heitzmann; J G Curd; Pojen P Chen; R Goldfien; Dennis A Carson
Cloning and sequence determination of a human rheumatoid factor light-chain gene.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(7):2195-9.
1986: S Fong; Pojen P Chen; R I Fox; R D Goldfien; Gregg J Silverman; V Radoux; F Jirik; J H Vaughan; Dennis A Carson
Rheumatoid factors in human autoimmune disease: their origin, development and function.
Pathology and immunopathology research 1986;5(3-5):305-16.
1986: CJ Carrera; Erik Willis; R R Chilcote; M Kubota; Dennis A Carson
5'-deoxy-5'-methylthioadenosine phosphorylase deficiency in leukemia: genetics and biochemical aspects.
Advances in experimental medicine and biology 1986;195 Pt B():643-50.
1986: Dennis A Carson; CJ Carrera; M Kubota; D B Wasson; T Iizasa
Genetic analysis of deoxyadenosine toxicity in dividing human lymphoblasts.
Advances in experimental medicine and biology 1986;195 Pt B():207-11.
1985: Dennis A Carson; T Iizasa; S Seto; CJ Carrera; M Kubota; Erik Willis; D B Wasson; O Kajander
Metabolic basis for immune dysfunction in adenosine deaminase deficiency.
Annals of the New York Academy of Sciences 1985;451():34-41.