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Melvin Andersen

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TOP 3
Barbara A Wetmore; Dominique J Brees; Reetu Singh; Paul B Watkins; Melvin Andersen; James Loy; Russell S Thomas
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Sudin Bhattacharya; Rory B Conolly; Norbert E Kaminski; Russell S Thomas; Melvin Andersen; Qiang Zhang
A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Qiang Zhang; Jingbo Pi; Courtney G Woods; Melvin Andersen
A systems biology perspective on Nrf2-mediated antioxidant response.

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2010: Barbara A Wetmore; Dominique J Brees; Reetu Singh; Paul B Watkins; Melvin Andersen; James Loy; Russell S Thomas
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Hepatology (Baltimore, Md.) 2010;51(6):2127-39.
2010: Sudin Bhattacharya; Rory B Conolly; Norbert E Kaminski; Russell S Thomas; Melvin Andersen; Qiang Zhang
A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(1):51-65.
2010: Qiang Zhang; Jingbo Pi; Courtney G Woods; Melvin Andersen
A systems biology perspective on Nrf2-mediated antioxidant response.
Toxicology and applied pharmacology 2010;244(1):84-97.
2010: Qiang Zhang; Sudin Bhattacharya; Melvin Andersen; Rory B Conolly
Computational systems biology and dose-response modeling in relation to new directions in toxicity testing.
Journal of toxicology and environmental health. Part B, Critical reviews 2010;13(2-4):253-76.
2010: Rebecca A Clewell; Jerry L Campbell; Susan M Ross; Kevin W Gaido; Harvey J Clewell; Melvin Andersen
Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response.
Toxicology in vitro : an international journal published in association with BIBRA 2010;24(1):327-34.
2010: Qiang Zhang; Sudin Bhattacharya; Douglas E Kline; Robert B Crawford; Rory B Conolly; Russell S Thomas; Norbert E Kaminski; Melvin Andersen
Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin.
BMC systems biology 2010;4():40.
2010: Melvin Andersen; David C Dorman; Harvey J Clewell; Michael D Taylor; Andy Nong
Multi-dose-route, multi-species pharmacokinetic models for manganese and their use in risk assessment.
Journal of toxicology and environmental health. Part A 2010;73(2):217-34.
2009: Russell S Thomas; Wenjun Bao; Tzu-Ming Chu; Marina Bessarabova; Tatiana Nikolskaya; Yuri Nikolsky; Melvin Andersen; Russell D Wolfinger
Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(2):311-21.
2009: Miyoung Yoon; Andy Nong; Harvey J Clewell; Michael D Taylor; David C Dorman; Melvin Andersen
Lactational transfer of manganese in rats: predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(1):23-43.
2009: courtney woods; Jingqi Fu; Peng Xue; Yongyong Hou; Linda J Pluta; Longlong Yang; Qiang Zhang; Russell S Thomas; Melvin Andersen; Jingbo Pi
Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages.
Toxicology and applied pharmacology 2009;238(1):27-36.
2009: Rebecca A Clewell; Linda Pluta; Russell S Thomas; Melvin Andersen
In utero exposure to chloroquine alters sexual development in the male fetal rat.
Toxicology and applied pharmacology 2009;237(3):366-74.
2009: Qiang Zhang; Jingbo Pi; courtney woods; Melvin Andersen
Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses.
Toxicology and applied pharmacology 2009;237(3):345-56.
2009: Andy Nong; Michael D Taylor; Harvey J Clewell; David C Dorman; Melvin Andersen
Manganese tissue dosimetry in rats and monkeys: accounting for dietary and inhaled Mn with physiologically based pharmacokinetic modeling.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):22-34.
2008: Micaela B Reddy; Ivan D Dobrev; Debra A McNett; Joseph M Tobin; Mark J Utell; Paul E Morrow; Jeanne Y Domoradzki; Kathleen P Plotzke; Melvin Andersen
Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans.
Toxicological sciences : an official journal of the Society of Toxicology 2008;105(2):275-85.
2008: Melvin Andersen; Harvey J Clewell; Edilberto Bermudez; Gabrielle A Willson; Russell S Thomas
Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2008;105(2):368-83.
2008: Harvey J Clewell; Yu Mei Tan; Jerry L Campbell; Melvin Andersen
Quantitative interpretation of human biomonitoring data.
Toxicology and applied pharmacology 2008;231(1):122-33.
2008: Melvin Andersen; Micaela B Reddy; Kathleen P Plotzke
Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?
Toxicology letters 2008;179(2):85-92.
2008: Melvin Andersen; John Butenhoff; Shu-Ching Chang; David G Farrar; Gerald L Kennedy; Christopher Lau; Geary W Olsen; Jennifer Seed; Kendall B Wallace
Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action.
Toxicological sciences : an official journal of the Society of Toxicology 2008;102(1):3-14.
2008: Ivan D Dobrev; Andy Nong; Kai H Liao; Micaela B Reddy; Kathleen P Plotzke; Melvin Andersen
Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies.
Inhalation toxicology 2008;20(4):361-73.
2008: David C Dorman; Melanie F Struve; Brian A Wong; Elizabeth A Gross; Carl U Parkinson; Gabrielle A Willson; Yu-Mei Tan; Jerry L Campbell; Justin G Teeguarden; Harvey J Clewell; Melvin Andersen
Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation.
Inhalation toxicology 2008;20(3):245-56.
2008: Qiang Zhang; Jingbo Pi; courtney woods; Annie M Jarabek; Harvey J Clewell; Melvin Andersen
Hormesis and adaptive cellular control systems.
Dose-response : a publication of International Hormesis Society 2008;6(2):196-208.
2008: Andy Nong; Justin G Teeguarden; Harvey J Clewell; David C Dorman; Melvin Andersen
Pharmacokinetic modeling of manganese in the rat IV: Assessing factors that contribute to brain accumulation during inhalation exposure.
Journal of toxicology and environmental health. Part A 2008;71(7):413-26.
2007: Kai H Liao; Yu-Mei Tan; Rory B Conolly; Susan J Borghoff; Michael L Gargas; Melvin Andersen; Harvey J Clewell
Bayesian estimation of pharmacokinetic and pharmacodynamic parameters in a mode-of-action-based cancer risk assessment for chloroform.
Risk analysis : an official publication of the Society for Risk Analysis 2007;27(6):1535-51.
2007: Wilson C J Chung; Toni R Pak; Shotaro Suzuki; Wendy A Pouliot; Melvin Andersen; Robert J Handa
Detection and localization of an estrogen receptor beta splice variant protein (ERbeta2) in the adult female rat forebrain and midbrain regions.
The Journal of comparative neurology 2007;505(3):249-67.
2007: Tami S McMullin; William H Hanneman; Brian K Cranmer; John D Tessari; Melvin Andersen
Oral absorption and oxidative metabolism of atrazine in rats evaluated by physiological modeling approaches.
Toxicology 2007;240(1-2):1-14.
2007: Micaela B Reddy; R John Looney; Mark J Utell; Kathleen P Plotzke; Melvin Andersen
Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(2):422-31.
2007: Justin G Teeguarden; Jeffrey Gearhart; Harvey J Clewell; Tammie R Covington; Andy Nong; Melvin Andersen
Pharmacokinetic modeling of manganese. III. Physiological approaches accounting for background and tracer kinetics.
Journal of toxicology and environmental health. Part A 2007;70(18):1515-26.
2007: Justin G Teeguarden; David C Dorman; Andy Nong; Tammie R Covington; Harvey J Clewell; Melvin Andersen
Pharmacokinetic modeling of manganese. II. Hepatic processing after ingestion and inhalation.
Journal of toxicology and environmental health. Part A 2007;70(18):1505-14.
2007: Justin G Teeguarden; David C Dorman; Tammie R Covington; Harvey J Clewell; Melvin Andersen
Pharmacokinetic modeling of manganese. I. Dose dependencies of uptake and elimination.
Journal of toxicology and environmental health. Part A 2007;70(18):1493-504.
2007: Greg P Dooley; William H Hanneman; David L Carbone; Marie E Legare; Melvin Andersen; John D Tessari
Development of an immunochemical detection method for atrazine-induced albumin adducts.
Chemical research in toxicology 2007;20(7):1061-6.
2007: Russell S Thomas; Bruce C Allen; Andy Nong; Longlong Yang; Edilberto Bermudez; Harvey J Clewell; Melvin Andersen
A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(1):240-8.
2007: Teresa L Leavens; Deepa Rao; Melvin Andersen; David C Dorman
Evaluating transport of manganese from olfactory mucosa to striatum by pharmacokinetic modeling.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):265-78.
2007: Carol J Belfiore; Raymond S H Yang; Laura S Chubb; Manupat Lohitnavy; Ornrat Lohitnavy; Melvin Andersen
Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling.
Toxicology 2007;234(1-2):59-72.
2007: Tami S McMullin; Melvin Andersen; John D Tessari; Brian K Cranmer; William H Hanneman
Estimating constants for metabolism of atrazine in freshly isolated rat hepatocytes by kinetic modeling.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(3):492-501.
2007: Tammie R Covington; P Robinan Gentry; Cynthia B Van Landingham; Melvin Andersen; Janet E Kester; Harvey J Clewell
The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene.
Regulatory toxicology and pharmacology : RTP 2007;47(1):1-18.
2007: Sun Ku Lee; Ying C Ou; Melvin Andersen; Raymond S H Yang
A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice.
Archives of toxicology 2007;81(2):101-11.
2006: Jeffry Schroeter; Julia Kimbell; Melvin Andersen; David C Dorman
Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):359-67.
2006: Melvin Andersen; Harvey J Clewell; Yu-Mei Tan; John Butenhoff; Geary W Olsen
Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives.
Toxicology 2006;227(1-2):156-64.
2006: Greg P Dooley; Jessica E Prenni; Pilar L Prentiss; Brian K Cranmer; Melvin Andersen; John D Tessari
Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine.
Chemical research in toxicology 2006;19(5):692-700.
2006: Wilson C J Chung; Toni R Pak; Michael J Weiser; Laura R Hinds; Melvin Andersen; Robert J Handa
Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta.
Brain research 2006;1082(1):50-60.
2006: Jeffry Schroeter; Julia Kimbell; Anna M Bonner; Kay C Roberts; Melvin Andersen; David C Dorman
Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(1):198-207.
2006: Werner K Lutz; Roman W Lutz; Melvin Andersen
Dose-incidence relationships derived from superposition of distributions of individual susceptibility on mechanism-based dose responses for biological effects.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(1):33-8.
2006: Melvin Andersen; Roman W Lutz; Kai H Liao; Werner K Lutz
Dose-incidence modeling: consequences of linking quantal measures of response to depletion of critical tissue targets.
Toxicological sciences : an official journal of the Society of Toxicology 2006;89(1):331-7.
2005: Carolyn J Broccardo; Ruth E Billings; Melvin Andersen; William H Hanneman
Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells.
Toxicological sciences : an official journal of the Society of Toxicology 2005;88(1):82-94.
2005: James E Dennison; Melvin Andersen; Raymond S H Yang
Pitfalls and related improvements of in vivo gas uptake pharmacokinetic experimental systems.
Inhalation toxicology 2005;17(11):539-48.
2005: Harvey J Clewell; P Robinan Gentry; Janet E Kester; Melvin Andersen
Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene.
Critical reviews in toxicology 2005;35(5):413-33.
2005: James E Dennison; Philip L Bigelow; Moiz M Mumtaz; Melvin Andersen; Ivan D Dobrev; Raymond S H Yang
Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling.
Journal of occupational and environmental hygiene 2005;2(3):127-35.
2005: Melvin Andersen; James E Dennison; Russell S Thomas; Rory B Conolly
New directions in incidence-dose modeling.
Trends in biotechnology 2005;23(3):122-7.
2005: Melvin Andersen; Russell S Thomas; Kevin W Gaido; Rory B Conolly
Dose-response modeling in reproductive toxicology in the systems biology era.
Reproductive toxicology (Elmsford, N.Y.) 2005;19(3):327-37.
2004: William Slikker; Melvin Andersen; Matthew S Bogdanffy; James S Bus; Steven D Cohen; Rory B Conolly; Raymond M David; Nancy G Doerrer; David C Dorman; David W Gaylor; Dale Hattis; John M Rogers; R Woodrow Setzer; James A Swenberg; Kendall Wallace
Dose-dependent transitions in mechanisms of toxicity: case studies.
Toxicology and applied pharmacology 2004;201(3):226-94.
2004: William Slikker; Melvin Andersen; Matthew S Bogdanffy; James S Bus; Steven D Cohen; Rory B Conolly; Raymond M David; Nancy G Doerrer; David C Dorman; David W Gaylor; Dale Hattis; John M Rogers; R Woodrow Setzer; James A Swenberg; Kendall Wallace
Dose-dependent transitions in mechanisms of toxicity.
Toxicology and applied pharmacology 2004;201(3):203-25.
2004: James E Dennison; Melvin Andersen; Harvey J Clewell; Raymond S H Yang
Development of a physiologically based pharmacokinetic model for volatile fractions of gasoline using chemical lumping analysis.
Environmental science & technology 2004;38(21):5674-81.
2004: James E Dennison; Philip L Bigelow; Melvin Andersen
Occupational exposure limits in the context of solvent mixtures, consumption of ethanol, and target tissue dose.
Toxicology and industrial health 2004;20(6-10):165-75.
2004: Harvey J Clewell; Melvin Andersen
Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene.
Critical reviews in toxicology 2004;34(5):385-445.
2004: Laura S Chubb; Melvin Andersen; Carolyn J Broccardo; Marie E Legare; Ruth E Billings; Charles E Dean; William H Hanneman
Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153.
Toxicologic pathology 2004;32(4):467-73.
2004: Lisa M Sweeney; Melvin Andersen; Michael L Gargas
Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically based nasal dosimetry model.
Toxicological sciences : an official journal of the Society of Toxicology 2004;79(2):394-403.
2004: Tami S McMullin; Melvin Andersen; Alan Nagahara; Trent D Lund; Toni R Pak; Robert J Handa; William H Hanneman
Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor action.
Toxicological sciences : an official journal of the Society of Toxicology 2004;79(2):278-86.
2004: C Tenley French; William H Hanneman; Laura S Chubb; Ruth E Billings; Melvin Andersen
Induction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit element.
Toxicological sciences : an official journal of the Society of Toxicology 2004;78(2):276-86.
2004: Carolyn J Broccardo; Ruth E Billings; Laura S Chubb; Melvin Andersen; William H Hanneman
Single cell analysis of switch-like induction of CYP1A1 in liver cell lines.
Toxicological sciences : an official journal of the Society of Toxicology 2004;78(2):287-94.
2003: Jill M Brzezicki; Melvin Andersen; Brian K Cranmer; John D Tessari
Quantitative identification of atrazine and its chlorinated metabolites in plasma.
Journal of analytical toxicology 2003;27(8):569-73.
2003: James E Dennison; Melvin Andersen; Raymond S H Yang
Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach.
Inhalation toxicology 2003;15(10):961-86.
2003: Melvin Andersen; Rory B Conolly; David W Gaylor
Thresholds of carcinogenicity in the ED01 study.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):486-7; author reply 487-8.
2003: Ying C Ou; Rory B Conolly; Russell S Thomas; Daniel L Gustafson; Michael E Long; Ivan D Dobrev; Laura S Chubb; Yihua Xu; Smadar A Lapidot; Melvin Andersen; Raymond S H Yang
Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):301-14.
2003: Tami S McMullin; Jill M Brzezicki; Brian K Cranmer; John D Tessari; Melvin Andersen
Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine.
Journal of toxicology and environmental health. Part A 2003;66(10):941-64.
2003: Ivan D Dobrev; Micaela B Reddy; Kathleen P Plotzke; Sudarsanan Varaprath; Debra A McNett; Jeremy Durham; Melvin Andersen
Closed-chamber inhalation pharmacokinetic studies with hexamethyldisiloxane in the rat.
Inhalation toxicology 2003;15(6):589-617.
2003: Micaela B Reddy; Melvin Andersen; Paul E Morrow; Ivan D Dobrev; Sudarsanan Varaprath; Kathleen P Plotzke; Mark J Utell
Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(1):3-18.
2003: Melvin Andersen
Toxicokinetic modeling and its applications in chemical risk assessment.
Toxicology letters 2003;138(1-2):9-27.
2003: Christopher R Kirman; Michael L Gargas; Randy Deskin; Lisa Tonner-Navarro; Melvin Andersen
A physiologically based pharmacokinetic model for acrylamide and its metabolite, glycidamide, in the rat.
Journal of toxicology and environmental health. Part A 2003;66(3):253-74.
2003: Ramesh Sarangapani; Justin G Teeguarden; Melvin Andersen; Richard H Reitz; Kathleen P Plotzke
Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models.
Toxicological sciences : an official journal of the Society of Toxicology 2003;71(1):41-52.
2002: Melvin Andersen; Raymond S H Yang; C Tenley French; Laura S Chubb; James E Dennison
Molecular circuits, biological switches, and nonlinear dose-response relationships.
Environmental health perspectives 2002;110 Suppl 6():971-8.
2002: Kai H Liao; Ivan D Dobrev; James E Dennison; Melvin Andersen; Brad Reisfeld; Kenneth F Reardon; Julie A Campain; Wei Wei; Michael T Klein; Richard J Quann; Raymond S H Yang
Application of biologically based computer modeling to simple or complex mixtures.
Environmental health perspectives 2002;110 Suppl 6():957-63.
2002: Melvin Andersen; Trevor Green; Clay B Frederick; Matthew S Bogdanffy
Physiologically based pharmacokinetic (PBPK) models for nasal tissue dosimetry of organic esters: assessing the state-of-knowledge and risk assessment applications with methyl methacrylate and vinyl acetate.
Regulatory toxicology and pharmacology : RTP 2002;36(3):234-45.
2002: Ivan D Dobrev; Melvin Andersen; Raymond S H Yang
In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane.
Environmental health perspectives 2002;110(10):1031-9.
2002: P Robinan Gentry; Tammie R Covington; Melvin Andersen; Harvey J Clewell
Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration.
Regulatory toxicology and pharmacology : RTP 2002;36(1):51-68.
2002: Melvin Andersen; Ivan D Dobrev; Micaela B Reddy; Ramesh Sarangapani; Richard H Reitz; Kathleen P Plotzke
Further comments on the bioavailability of D4.
Environmental health perspectives 2002;110(8):A444-5; author reply A445-8.
2002: Ramesh Sarangapani; Harvey J Clewell; George Cruzan; Melvin Andersen
Comparing respiratory-tract and hepatic exposure-dose relationships for metabolized inhaled vapors: a pharmacokinetic analysis.
Inhalation toxicology 2002;14(8):835-54.
2002: Ramesh Sarangapani; Justin G Teeguarden; George Cruzan; Harvey J Clewell; Melvin Andersen
Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans.
Inhalation toxicology 2002;14(8):789-834.
2002: Ramesh Sarangapani; Justin G Teeguarden; Kathleen P Plotzke; James M McKim; Melvin Andersen
Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane.
Toxicological sciences : an official journal of the Society of Toxicology 2002;67(2):159-72.
2002: Melvin Andersen
The use of quantitative histological and molecular data for risk assessment and biologically based model development.
Toxicologic pathology 2002;30(1):106-11.
2001: Harvey J Clewell; P Robinan Gentry; Jeffery M Gearhart; Tammie R Covington; M I Banton; Melvin Andersen
Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone.
Toxicological sciences : an official journal of the Society of Toxicology 2001;63(2):160-72.
2001: Harvey J Clewell; P Robinan Gentry; Jeffery M Gearhart; Bruce C Allen; Melvin Andersen
Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.
The Science of the total environment 2001;274(1-3):37-66.
2001: Melvin Andersen; James E Dennison
Mode of action and tissue dosimetry in current and future risk assessments.
The Science of the total environment 2001;274(1-3):3-14.
2001: Ivan D Dobrev; Melvin Andersen; Raymond S H Yang
Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling.
Archives of toxicology 2001;75(3):134-44.
2001: Melvin Andersen; A M Jarabek
Nasal tissue dosimetry-issues and approaches for "Category 1" gases: a report on a meeting held in Research Triangle Park, NC, February 11-12, 1998.
Inhalation toxicology 2001;13(5):415-35.
2001: Melvin Andersen; Ramesh Sarangapani
Physiologically based clearance/extraction models for compounds metabolized in the nose: an example with methyl methacrylate.
Inhalation toxicology 2001;13(5):397-414.
2001: Matthew S Bogdanffy; David Plowchalk; Ramesh Sarangapani; T B Starr; Melvin Andersen
Mode-of-action-based dosimeters for interspecies extrapolation of vinyl acetate inhalation risk.
Inhalation toxicology 2001;13(5):377-96.
2001: Melvin Andersen; Ramesh Sarangapani; Richard H Reitz; Robert H Gallavan; Ivan D Dobrev; Kathleen P Plotzke
Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(2):214-31.
2001: Ying C Ou; Rory B Conolly; Russell S Thomas; Y Xu; Melvin Andersen; Laura S Chubb; H C Pitot; Raymond S H Yang
A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay.
Cancer research 2001;61(5):1879-89.
2000: Melvin Andersen; D Krewski
Biologically based risk assessment model for cyclophosphamide hematotoxicity in animal species: concluding comments.
Journal of toxicology and environmental health. Part A 2000;61(5-6):543-52.
2000: Hugh A Barton; PJ Deisinger; Caroline English; J N Gearhart; W D Faber; Tipton Tyler; Marcy I Banton; Justin G Teeguarden; Melvin Andersen
Family approach for estimating reference concentrations/doses for series of related organic chemicals.
Toxicological sciences : an official journal of the Society of Toxicology 2000;54(1):251-61.
2000: Marina V Evans; Melvin Andersen
Sensitivity analysis of a physiological model for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): assessing the impact of specific model parameters on sequestration in liver and fat in the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2000;54(1):71-80.
2000: Melvin Andersen; M E Meek; G A Boorman; DJ Brusick; SM Cohen; YP Dragan; Clay B Frederick; Jay I Goodman; GC Hard; E J O'Flaherty; D E Robinson
Lessons learned in applying the U.S. EPA proposed cancer guidelines to specific compounds.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):159-72.
1999: Melvin Andersen; Ramesh Sarangapani; Clay B Frederick; Julia Kimbell
Dosimetric adjustment factors for methyl methacrylate derived from a steady-state analysis of a physiologically based clearance-extraction model.
Inhalation toxicology 1999;11(10):899-926.
1999: Matthew S Bogdanffy; Ramesh Sarangapani; David Plowchalk; A Jarabek; Melvin Andersen
A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity.
Toxicological sciences : an official journal of the Society of Toxicology 1999;51(1):19-35.
1999: Melvin Andersen; Rory B Conolly; E M Faustman; Robert Kavlock; Christopher Portier; D M Sheehan; P J Wier; L Ziese
Quantitative mechanistically based dose-response modeling with endocrine-active compounds.
Environmental health perspectives 1999;107 Suppl 4():631-8.
1999: Melvin Andersen; Jeffery M Gearhart; Harvey J Clewell
Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese.
Neurotoxicology 1999;20(2-3):161-71.
1998: H A Barton; Melvin Andersen; Bruce C Allen
Dose-response characteristics of uterine responses in rats exposed to estrogen agonists.
Regulatory toxicology and pharmacology : RTP 1998;28(2):133-49.
1998: PD Lilly; J R Thornton-Manning; Michael L Gargas; Harvey J Clewell; Melvin Andersen
Kinetic characterization of CYP2E1 inhibition in vivo and in vitro by the chloroethylenes.
Archives of toxicology 1998;72(10):609-21.
1998: PD Lilly; Melvin Andersen; Tracey M Ross; Rex A Pegram
A physiologically based pharmacokinetic description of the oral uptake, tissue dosimetry, and rates of metabolism of bromodichloromethane in the male rat.
Toxicology and applied pharmacology 1998;150(2):205-17.
1998: Melvin Andersen; HA Barton
The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposure.
Environmental health perspectives 1998;106 Suppl 1():349-55.
1997: PD Lilly; Melvin Andersen; Tracey M Ross; Rex A Pegram
Physiologically based estimation of in vivo rates of bromodichloromethane metabolism.
Toxicology 1997;124(2):141-52.
1997: Melvin Andersen; Harvey J Clewell; J Gearhart; Bruce C Allen; H A Barton
Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors.
Journal of toxicology and environmental health 1997;52(3):189-209.
1997: N P Page; D V Singh; W Farland; Jay I Goodman; Rory B Conolly; Melvin Andersen; Harvey J Clewell; Clay B Frederick; H Yamasaki; G Lucier
Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1997;37(1):16-36.
1997: Rex A Pegram; Melvin Andersen; Sarah H Warren; Tracey M Ross; Larry Davis Claxton
Glutathione S-transferase-mediated mutagenicity of trihalomethanes in Salmonella typhimurium: contrasting results with bromodichloromethane off chloroform.
Toxicology and applied pharmacology 1997;144(1):183-8.
1997: Melvin Andersen; L S Birnbaum; HA Barton; C R Eklund
Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation.
Toxicology and applied pharmacology 1997;144(1):145-55.
1997: Melvin Andersen; C R Eklund; J J Mills; HA Barton; L S Birnbaum
A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s.
Toxicology and applied pharmacology 1997;144(1):135-44.
1997: David Plowchalk; Melvin Andersen; Matthew S Bogdanffy
Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in the rat nasal cavity.
Toxicology and applied pharmacology 1997;142(2):386-400.
1996: R H Reitz; Michael L Gargas; Melvin Andersen; W M Provan; T L Green
Predicting cancer risk from vinyl chloride exposure with a physiologically based pharmacokinetic model.
Toxicology and applied pharmacology 1996;137(2):253-67.
1995: Michael L Gargas; Melvin Andersen; S K Teo; R Batra; Timothy R Fennell; Gregory L Kedderis
A physiologically based dosimetry description of acrylonitrile and cyanoethylene oxide in the rat.
Toxicology and applied pharmacology 1995;134(2):185-94.
1995: Melvin Andersen; J J Mills; Randy L Jirtle; William F Greenlee
Negative selection in hepatic tumor promotion in relation to cancer risk assessment.
Toxicology 1995;102(1-2):223-37.
1995: Harvey J Clewell; P Robinan Gentry; Jeffery M Gearhart; Bruce C Allen; Melvin Andersen
Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene.
Chemosphere 1995;31(1):2561-78.
1995: Susan J Borghoff; Michael L Gargas; Melvin Andersen; Rory B Conolly
Development of a mechanism-based dosimetry model for 2,4,4-trimethyl-2-pentanol-induced alpha 2u-globulin nephropathy in male Fischer 344 rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;25(1):124-37.
1994: Jeffery M Gearhart; G W Jepson; Harvey J Clewell; Melvin Andersen; Rory B Conolly
Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate esters.
Environmental health perspectives 1994;102 Suppl 11():51-60.
1994: Melvin Andersen; Harvey J Clewell; D A Mahle; Jeffery M Gearhart
Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo.
Toxicology and applied pharmacology 1994;128(1):158-65.
1994: Melvin Andersen; J J Mills; TR Fox; Thomas L Goldsworthy; Rory B Conolly; Linda S Birnbaum
Receptor-mediated toxicity and implications for risk assessment.
Progress in clinical and biological research 1994;387():295-310.
1993: L B Kedderis; Melvin Andersen; Linda S Birnbaum
Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;21(4):405-11.
1993: L B Kedderis; J J Mills; Melvin Andersen; Linda S Birnbaum
A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction.
Toxicology and applied pharmacology 1993;121(1):87-98.
1993: J J Mills; Melvin Andersen
Dioxin hepatic carcinogenesis: biologically motivated modeling and risk assessment.
Toxicology letters 1993;68(1-2):177-89.
1993: Melvin Andersen; J J Mills; Michael L Gargas; L Kedderis; Linda S Birnbaum; D Neubert; William F Greenlee
Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment.
Risk analysis : an official publication of the Society for Risk Analysis 1993;13(1):25-36.
1992: David Plowchalk; Melvin Andersen; J D deBethizy
A physiologically based pharmacokinetic model for nicotine disposition in the Sprague-Dawley rat.
Toxicology and applied pharmacology 1992;116(2):177-88.
1992: K Krishnan; Michael L Gargas; Timothy R Fennell; Melvin Andersen
A physiologically based description of ethylene oxide dosimetry in the rat.
Toxicology and industrial health 1992;8(3):121-40.
1992: Melvin Andersen; K Krishnan; Rory B Conolly; R O McClellan
Biologically based modeling in toxicology research.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1992;15():217-27.
1991: Melvin Andersen; Harvey J Clewell; Michael L Gargas; M G MacNaughton; R H Reitz; R J Nolan; M J McKenna
Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans.
Toxicology and applied pharmacology 1991;108(1):14-27.
1991: Rory B Conolly; Melvin Andersen
Biologically based pharmacodynamic models: tools for toxicological research and risk assessment.
Annual review of pharmacology and toxicology 1991;31():503-23.
1990: Jeffery M Gearhart; G W Jepson; Harvey J Clewell; Melvin Andersen; Rory B Conolly
Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate.
Toxicology and applied pharmacology 1990;106(2):295-310.
1990: R H Reitz; Alan L Mendrala; R A Corley; J F Quast; Michael L Gargas; Melvin Andersen; D A Staats; Rory B Conolly
Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling.
Toxicology and applied pharmacology 1990;105(3):443-59.
1990: R H Reitz; P S McCroskey; C N Park; Melvin Andersen; Michael L Gargas
Development of a physiologically based pharmacokinetic model for risk assessment with 1,4-dioxane.
Toxicology and applied pharmacology 1990;105(1):37-54.
1990: R A Corley; Alan L Mendrala; F A Smith; D A Staats; Michael L Gargas; Rory B Conolly; Melvin Andersen; R H Reitz
Development of a physiologically based pharmacokinetic model for chloroform.
Toxicology and applied pharmacology 1990;103(3):512-27.
1990: Jeffrey W Fisher; T A Whittaker; D H Taylor; Harvey J Clewell; Melvin Andersen
Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.
Toxicology and applied pharmacology 1990;102(3):497-513.
1990: J N McDougal; G W Jepson; Harvey J Clewell; Michael L Gargas; Melvin Andersen
Dermal absorption of organic chemical vapors in rats and humans.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;14(2):299-308.
1989: Harvey J Clewell; Melvin Andersen
Improving toxicology testing protocols using computer simulations.
Toxicology letters 1989;49(2-3):139-58.
1989: Melvin Andersen
Tissue dosimetry, physiologically-based pharmacokinetic modeling, and cancer risk assessment.
Cell biology and toxicology 1989;5(4):405-15.
1989: Jeffrey W Fisher; T A Whittaker; D H Taylor; Harvey J Clewell; Melvin Andersen
Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.
Toxicology and applied pharmacology 1989;99(3):395-414.
1989: Michael L Gargas; Melvin Andersen
Determining kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation.
Toxicology and applied pharmacology 1989;99(2):344-53.
1989: Michael L Gargas; R J Burgess; D E Voisard; G H Cason; Melvin Andersen
Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues.
Toxicology and applied pharmacology 1989;98(1):87-99.
1989: Harvey J Clewell; Melvin Andersen
Biologically motivated models for chemical risk assessment.
Health physics 1989;57 Suppl 1():129-37.
1988: Harvey J Clewell; Melvin Andersen; M G MacNaughton; B O Stuart
Toxicokinetics: an analytical tool for assessing chemical hazards to man.
Aviation, space, and environmental medicine 1988;59(11 Pt 2):A125-31.
1988: R H Reitz; Alan L Mendrala; C N Park; Melvin Andersen; F P Guengerich
Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: implications for risk assessment.
Toxicology letters 1988;43(1-3):97-116.
1988: M L Shelley; Melvin Andersen; Jeffrey W Fisher
An inhalation distribution model for the lactating mother and nursing child.
Toxicology letters 1988;43(1-3):23-9.
1988: Rory B Conolly; R H Reitz; Harvey J Clewell; Melvin Andersen
Pharmacokinetics, biochemical mechanism and mutation accumulation: a comprehensive model of chemical carcinogenesis.
Toxicology letters 1988;43(1-3):189-200.
1987: P G Watanabe; T R Fox; R H Reitz; A M Schumann; Melvin Andersen
Research strategy in industrial toxicology.
The Journal of toxicological sciences 1987;12(2):223-33.
1987: Melvin Andersen; M G MacNaughton; Harvey J Clewell; D J Paustenbach
Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model.
American Industrial Hygiene Association journal 1987;48(4):335-43.
1987: Melvin Andersen; Harvey J Clewell; Michael L Gargas; F A Smith; R H Reitz
Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.
Toxicology and applied pharmacology 1987;87(2):185-205.
1986: J N McDougal; G W Jepson; Harvey J Clewell; M G MacNaughton; Melvin Andersen
A physiological pharmacokinetic model for dermal absorption of vapors in the rat.
Toxicology and applied pharmacology 1986;85(2):286-94.
1985: J N McDougal; G W Jepson; Harvey J Clewell; Melvin Andersen
Dermal absorption of dihalomethane vapors.
Toxicology and applied pharmacology 1985;79(1):150-8.