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Markus Grompe

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Svitlana Kurinna; Jill M Schumacher; Sabrina A Stratton; Zeynep Coban; Andrew W Duncan; Markus Grompe; Michelle Craig Barton
p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver.
Holger Willenbring; Markus Grompe
A Therapy for Liver Failure Found in the JNK Yard.
Nuria C Bramswig; Craig Dorrell; Logan J Everett; Markus Grompe; Chengyang Liu; Yanping Luo; Ali Naji; Jonathan Schug; Philip R Streeter; Klaus H Kaestner
Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

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2013: Svitlana Kurinna; Jill M Schumacher; Sabrina A Stratton; Zeynep Coban; Andrew W Duncan; Markus Grompe; Michelle Craig Barton
p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver.
Hepatology (Baltimore, Md.) 2013;57(5):2004-13.
2013: Holger Willenbring; Markus Grompe
A Therapy for Liver Failure Found in the JNK Yard.
Cell 2013;153(2):283-4.
2013: Nuria C Bramswig; Craig Dorrell; Logan J Everett; Markus Grompe; Chengyang Liu; Yanping Luo; Ali Naji; Jonathan Schug; Philip R Streeter; Klaus H Kaestner
Epigenomic plasticity enables human pancreatic α to β cell reprogramming.
The Journal of clinical investigation 2013;123(3):1275-84.
2013: Meritxell Huch; Vivian S W Li; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Johan H van Es; Robert G J Vries; Craig Dorrell; Milton J Finegold; Markus Grompe; Annelise Haft; Karien Hamer; Sylvia F Boj; Hans Clevers
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Nature 2013;494(7436):247-50.
2013: Terry K Morgan; Brett C Sheppard; Henry Van de Vrugt; Sandra L White; Robert Bonnah; Christopher L Corless; Ediz F Cosar; Markus Grompe; Karin Hardiman; Philip R Streeter
Human pancreatic cancer fusion 2 (HPC2) 1-B3: a novel monoclonal antibody to screen for pancreatic ductal dysplasia.
Cancer cytopathology 2013;121(1):37-46.
2012: Ashley M Vaughan; Elizabeth M Wilson; Alexis Kaushansky; mikolajczak sebastian; Alexander Ploss; John Bial; Nelly Camargo; Markus Grompe; Stefan Kappe
Complete Plasmodium falciparum liver-stage development in liver-chimeric mice.
The Journal of clinical investigation 2012;122(10):3618-28.
2012: Zhongya Wang; Milton J Finegold; Mark A Kay; Leszek Lisowski; Hiroyuki Nakai; Markus Grompe
AAV vectors containing rDNA homology display increased chromosomal integration and transgene persistence.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1902-11.
2012: Leszek Lisowski; Zhongya Wang; Feijie Zhang; Yue Zhang; Markus Grompe; Ashley Lau; Mark A Kay
Ribosomal DNA integrating rAAV-rDNA vectors allow for stable transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1912-23.
2012: Nicole K Paulk; Carl Pelz; John F Witte; Karsten Wursthorn; Raymond L Bateman; Gregory Clarke; Milton J Finegold; Annelise Haft; Cary O Harding; Ronald McClard; Amy H Newell; Susan B Olson; Markus Grompe
In vivo selection of transplanted hepatocytes by pharmacological inhibition of fumarylacetoacetate hydrolase in wild-type mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1981-7.
2012: Jody E Hooper; Terry K Morgan; Brett C Sheppard; Christopher L Corless; Markus Grompe; Megan L Troxell; Philip R Streeter
The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma.
Human pathology 2012;43(10):1583-9.
2012: Andrew W Duncan; Milton J Finegold; Arthur L Beaudet; Weimin Bi; Amy E Hanlon Newell; Susan B Olson; Markus Grompe
Aneuploidy as a mechanism for stress-induced liver adaptation.
The Journal of clinical investigation 2012;122(9):3307-15.
2012: Raphael Ceccaldi; Alan D D'Andrea; Marc Delord; Eliane Gluckman; Markus Grompe; Jung Min Kim; Jérôme Larghero; Thierry Leblanc; Enguerran Mouly; Kalindi Parmar; Régis Peffault de Latour; Marika Pla; Corinne Pondarre; Marie Regairaz; Gérard Socié; Nadia Vasquez; Qing-Shuo Zhang; Marina Cavazzana-Calvo; Jean Soulier
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.
Cell stem cell 2012;11(1):36-49.
2012: Amy M Skinner; Markus Grompe; Peter Kurre
Intra-hematopoietic cell fusion as a source of somatic variation in the hematopoietic system.
Journal of cell science 2012;125(Pt 12):2837-43.
2012: Markus Grompe
Tissue stem cells: new tools and functional diversity.
Cell stem cell 2012;10(6):685-9.
2012: Nicole K Paulk; Laura Marquez Loza; Milton J Finegold; Markus Grompe
AAV-mediated gene targeting is significantly enhanced by transient inhibition of nonhomologous end joining or the proteasome in vivo.
Human gene therapy 2012;23(6):658-65.
2011: Craig Dorrell; A J Fox; Robert A Bonnah; P S Canaday; Klaus kaestner; C F Lin; Jonathan Schug; O Smirnova; C J Stoeckert; Philip R Streeter; Markus Grompe
Transcriptomes of the major human pancreatic cell types.
Diabetologia 2011;54(11):2832-44.
2011: Raymond D Hickey; Sean E Hofherr; Joseph B Lillegard; Travis J McKenzie; Scott L Nyberg; Milton J Finegold; James E Fisher; Markus Grompe
Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer.
Hepatology (Baltimore, Md.) 2011;54(4):1351-9.
2011: Patrick Viatour; Hannes Vogel; Anne-Flore Zmoos; Bethany E Schaffer; Karl G Sylvester; Snorri S Thorgeirsson; Jesper B andersen; Craig Dorrell; Ursula Ehmer; Markus Grompe; Chenwei Lin; Pawel K Mazur; Austin Ostermeier; Louis A Saddic; Julien Sage
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.
The Journal of experimental medicine 2011;208(10):1963-76.
2011: Eleanor S Click; Barbara Cox; Markus Grompe; Kathleen A Leppig; Yajuan J Liu; Dana C Matthews; Lisa A Moreau; Susan B Olson; Akiko Shimamura; Darci L Sternen; Yassmine Akkari; Melissa A Parisi
Fanconi anemia-like presentation in an infant with constitutional deletion of 21q including the RUNX1 gene.
American journal of medical genetics. Part A 2011;155A(7):1673-9.
2011: Craig Dorrell; Dale L Greiner; Pamela S Canaday; Maria T Grompe; Fong Cheng Pan; Leonard D Shultz; Philip R Streeter; Chris V Wright; Yongping Zhong; Markus Grompe
Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.
Molecular and cellular endocrinology 2011;339(1-2):144-50.
2011: Craig Dorrell; Laura Erker; Jonathan Schug; Janel L Kopp; Pamela S Canaday; Alan J Fox; Olga Smirnova; Andrew W Duncan; Milton J Finegold; Maike Sander; Klaus kaestner; Markus Grompe
Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice.
Genes & development 2011;25(11):1193-203.
2011: Soona Shin; Gabriel Walton; Reina Aoki; Karrie Brondell; Jonathan Schug; Alan Fox; Olga Smirnova; Craig Dorrell; Laura Erker; Andrew S Chu; Rebecca G Wells; Markus Grompe; Linda E Greenbaum; Klaus kaestner
Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential.
Genes & development 2011;25(11):1185-92.
2010: Qing-Shuo Zhang; Laura Marquez-Loza; Laura Eaton; Andrew W Duncan; Devorah C Goldman; Anur Praveen; Kevin Watanabe-Smith; R Keaney Rathbun; William H Fleming; Grover C Bagby; Markus Grompe
Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol.
Blood 2010;116(24):5140-8.
2010: Jung Wook Park; Henry C Pitot; Katerina Strati; Nicole Spardy; Stefan Duensing; Markus Grompe; Paul F Lambert
Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.
Cancer research 2010;70(23):9959-68.
2010: Andrew W Duncan; Matthew H Taylor; Raymond D Hickey; Amy E Hanlon Newell; Michelle L Lenzi; Susan B Olson; Milton J Finegold; Markus Grompe
The ploidy conveyor of mature hepatocytes as a source of genetic variation.
Nature 2010;467(7316):707-10.
2010: Sam Laurel Stephen; Eugenio Montini; Vijayshankar Ganesh Sivanandam; Muhseen Al-Dhalimy; Hans A Kestler; Milton Finegold; Markus Grompe; Stefan Kochanek
Chromosomal integration of adenoviral vector DNA in vivo.
Journal of virology 2010;84(19):9987-94.
2010: Laura Erker; Hisaya Azuma; Andrew Y Lee; Changsheng Guo; Susan L Orloff; Laura Eaton; Eric Benedetti; Bryan Jensen; Milton Finegold; Holger Willenbring; Markus Grompe
Therapeutic liver reconstitution with murine cells isolated long after death.
Gastroenterology 2010;139(3):1019-29.
2010: Nicole K Paulk; Karsten Wursthorn; Zhongya Wang; Milton J Finegold; Mark A Kay; Markus Grompe
Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo.
Hepatology (Baltimore, Md.) 2010;51(4):1200-8.
2010: Stephen C Strom; Julio Davila; Markus Grompe
Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity.
Methods in molecular biology (Clifton, N.J.) 2010;640():491-509.
2010: Shaomei Wang; Bin Lu; Sergej Girman; Jie Duan; Trevor McFarland; Qing-Shuo Zhang; Markus Grompe; Grazyna Adamus; Binoy Appukuttan; Raymond Lund
Non-invasive stem cell therapy in a rat model for retinal degeneration and vascular pathology.
PloS one 2010;5(2):e9200.
2009: Henri J van de Vrugt; Laura Eaton; Amy Hanlon Newell; Muhsen Al-Dhalimy; R Michael Liskay; Susan B Olson; Markus Grompe
Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.
Cancer research 2009;69(24):9431-8.
2009: Hathaitip Sritanaudomchai; Michelle Sparman; Masahito Tachibana; Lisa Clepper; Joy Woodward; Sumita Gokhale; Don Wolf; Jon D Hennebold; William Hurlbut; Markus Grompe; Shoukhrat Mitalipov
CDX2 in the formation of the trophectoderm lineage in primate embryos.
Developmental biology 2009;335(1):179-87.
2009: Paul Gadue; Valerie Gouon-Evans; Xin Cheng; Ewa Wandzioch; Kenneth S Zaret; Markus Grompe; Philip R Streeter; Gordon M Keller
Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm.
Stem cells (Dayton, Ohio) 2009;27(9):2103-13.
2009: Andrew W Duncan; Craig Dorrell; Markus Grompe
Stem cells and liver regeneration.
Gastroenterology 2009;137(2):466-81.
2009: Nabil N Moghrabi; Monique A Johnson; Marvin J Yoshitomi; Xiaoman Zhu; Muhsen J Al-Dhalimy; Susan B Olson; Markus Grompe; Carolyn S (Sue) Richards
Validation of Fanconi anemia complementation Group A assignment using molecular analysis.
Genetics in medicine : official journal of the American College of Medical Genetics 2009;11(3):183-92.
2009: Andrew W Duncan; Raymond D Hickey; Nicole K Paulk; Andrew J Culberson; Susan B Olson; Milton J Finegold; Markus Grompe
Ploidy reductions in murine fusion-derived hepatocytes.
PLoS genetics 2009;5(2):e1000385.
2009: A Hemphill; Yassmine Akkari; A H Newell; R A Schultz; Markus Grompe; P S North; I D Hickson; Petra Jakobs; S Rennie; D Pauw; James Hejna; Susan B Olson; Robb Moses
Topo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents.
Cytogenetic and genome research 2009;125(3):165-75.
2008: Kenneth S Zaret; Markus Grompe
Generation and regeneration of cells of the liver and pancreas.
Science (New York, N.Y.) 2008;322(5907):1490-4.
2008: Craig Dorrell; Laura Erker; Kelsea M Lanxon-Cookson; Stephanie L Abraham; Tristan Victoroff; Simon Ro; Pamela S Canaday; Philip R Streeter; Markus Grompe
Surface markers for the murine oval cell response.
Hepatology (Baltimore, Md.) 2008;48(4):1282-91.
2008: Craig Dorrell; Stephanie L Abraham; Kelsea M Lanxon-Cookson; Pamela S Canaday; Philip R Streeter; Markus Grompe
Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers.
Stem cell research 2008;1(3):183-94.
2008: Kevin McCabe; A Hemphill; Yassmine Akkari; Petra Jakobs; Daniel Pauw; Susan B Olson; Robb Moses; Markus Grompe
ERCC1 is required for FANCD2 focus formation.
Molecular genetics and metabolism 2008;95(1-2):66-73.
2008: Silke Marhenke; Jutta Lamlé; Laura Elisa Buitrago-Molina; José Manuel Fernández Cañón; Robert Geffers; Milton Finegold; Michael B. Sporn; Masayuki Yamamoto; Michael P Manns; Markus Grompe; Arndt Vogel
Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development.
Hepatology (Baltimore, Md.) 2008;48(2):487-96.
2008: Holger Willenbring; Amar Deep Sharma; Arndt Vogel; Andrew Y Lee; Andreas Rothfuss; Zhongya Wang; Milton Finegold; Markus Grompe
Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis.
Cancer cell 2008;14(1):59-67.
2008: Qing-Shuo Zhang; Laura Eaton; Eric R Snyder; Scott Houghtaling; James B Mitchell; Milton Finegold; Carter Van Waes; Markus Grompe
Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.
Cancer research 2008;68(5):1601-8.
2008: Amy Skinner; S Lee O'Neill; Markus Grompe; Peter Kurre
CXCR4 induction in hematopoietic progenitor cells from Fanca(-/-), -c(-/-), and -d2(-/-) mice.
Experimental hematology 2008;36(3):273-82.
2007: Laura Erker; Markus Grompe
Signaling networks in hepatic oval cell activation.
Stem cell research 2007;1(2):90-102.
2007: Hisaya Azuma; Nicole Paulk; Aarati Ranade; Craig Dorrell; Muhsen Al-Dhalimy; Ewa Ellis; Stephen Strom; Mark A Kay; Milton Finegold; Markus Grompe
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice.
Nature biotechnology 2007;25(8):903-10.
2007: Markus Grompe; Henri van de Vrugt
The Fanconi family adds a fraternal twin.
Developmental cell 2007;12(5):661-2.
2007: Reinhard Kalb; Kornelia Neveling; Holger Hoehn; Hildegard Schneider; Yvonne Linka; Sat Dev Batish; Curtis Hunt; Marianne Berwick; Elsa Callen; Jordi Surralles; José A Casado; Juan A. Bueren; Angeles Dasi; Jean Soulier; Eliane Gluckman; C Michel Zwaan; Rosalina Spaendonk; Gerard Pals; Johan P de Winter; Hans Joenje; Markus Grompe; Arleen D Auerbach; Helmut Hanenberg; Detlev Schindler
Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype.
American journal of human genetics 2007;80(5):895-910.
2007: Raynard L Bateman; Justin Ashworth; John F Witte; LJ Baker; Pullooru Bhanumoorthy; David E Timm; Thomas D Hurley; Markus Grompe; Ronald W McClard
Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
The Biochemical journal 2007;402(2):251-60.
2006: Alessandra Biffi; Alessia Capotondo; Stefania Fasano; Ubaldo Del Carro; Sergio Marchesini; Hisaya Azuma; Mariachiara Malaguti; Stefano Amadio; Riccardo Brambilla; Markus Grompe; Claudio Bordignon; Angelo Quattrini; Luigi Naldini
Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice.
The Journal of clinical investigation 2006;116(11):3070-82.
2006: William B Hurlbut; Robert P George; Markus Grompe
Seeking consensus: a clarification and defense of altered nuclear transfer.
The Hastings Center report 2006;36(5):42-50.
2006: Alexis S Bailey; Holger Willenbring; Shuguang Jiang; Daniel A Anderson; David A Schroeder; Melissa H Wong; Markus Grompe; William H Fleming
Myeloid lineage progenitors give rise to vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13156-61.
2006: Adnan Z Rizvi; John R Swain; Paige S Davies; Alexis S Bailey; Adria D Decker; Holger Willenbring; Markus Grompe; William H Fleming; Melissa H Wong
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6321-5.
2006: Anuj Mankad; Toshiyasu Taniguchi; Barbara Cox; Yassmine Akkari; R Keaney Rathbun; Lora Lucas; Grover C Bagby; Susan B Olson; Alan D D'Andrea; Markus Grompe
Natural gene therapy in monozygotic twins with Fanconi anemia.
Blood 2006;107(8):3084-90.
2006: Markus Grompe
Principles of therapeutic liver repopulation.
Journal of inherited metabolic disease 2006;29(2-3):421-5.
2006: Arndt Vogel; Joseph E Aslan; Holger Willenbring; Christian Klein; Milton Finegold; Howard Mount; Gary Thomas; Markus Grompe
Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.
Gastroenterology 2006;130(1):104-19.
2006: Patrice K Held; Muhsen Al-Dhalimy; Holger Willenbring; Yassmine Akkari; Shuguang Jiang; Yumi Torimaru; Susan B Olson; William H Fleming; Milton Finegold; Markus Grompe
In vivo genetic selection of renal proximal tubules.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(1):49-58.
2005: Markus Grompe
Embryonic stem cells without embryos?
Nature biotechnology 2005;23(12):1496-7.
2005: Scott Houghtaling; Amy Newell; Yassmine Akkari; Toshiyasu Taniguchi; Susan B Olson; Markus Grompe
Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.
Human molecular genetics 2005;14(20):3027-33.
2005: Kelly J Hamman; Heather Clark; Eugenio Montini; Muhsen Al-Dhalimy; Markus Grompe; Milton Finegold; Cary O Harding
Low therapeutic threshold for hepatocyte replacement in murine phenylketonuria.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):337-44.
2005: Markus Grompe
The origin of hepatocytes.
Gastroenterology 2005;128(7):2158-60.
2005: Hiroyuki Nakai; Xiaolin Wu; Sally Fuess; Theresa A Storm; David J Munroe; Eugenio Montini; Shawn M Burgess; Markus Grompe; Mark A Kay
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver.
Journal of virology 2005;79(6):3606-14.
2005: Patrice K Held; Eric C Olivares; Christina P Aguilar; Milton Finegold; Michele P Calos; Markus Grompe
In vivo correction of murine hereditary tyrosinemia type I by phiC31 integrase-mediated gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(3):399-408.
2005: Rocio Montes de Oca; Paul R Andreassen; Steven P Margossian; Richard C. Gregory; Toshiyasu Taniguchi; Xiaozhe Wang; Scott Houghtaling; Markus Grompe; Alan D D'Andrea
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.
Blood 2005;105(3):1003-9.
2005: Craig Dorrell; Markus Grompe
Liver repair by intra- and extrahepatic progenitors.
Stem cell reviews 2005;1(1):61-4.
2005: Hadley Arkes; Nicanor Pier Giorgio Austriaco; Thomas Berg; E Christian Brugger; Nigel M de S Cameron; Joseph Capizzi; Maureen L Condic; Samuel B Condic; Kevin T FitzGerald; Kevin Flannery; Edward J Furton; Robert P George; Timothy George; Alfonso Gomez-Lobo; Germain Grisez; Markus Grompe; John M Haas; Robert Hamerton-Kelly; John Collins Harvey; Paul J Hoehner; William B Hurlbut; John F Kilner; Patrick Lee; William E May; Gonzalo Miranda; C Ben Mitchell; John J Myers; Chris Oleson; Tad Pacholczyk; Peter F Ryan; William L Saunders; David Stevens; Stuart W Swetland; M Edward Whelan; Thomas Williams
Production of pluripotent stem cells by oocyte-assisted reprogramming: joint statement with signatories.
The national Catholic bioethics quarterly 2005;5(3):579-83.
2005: Markus Grompe
Bone marrow-derived hepatocytes.
Novartis Foundation symposium 2005;265():20-7; discussion 28-34, 92-7.
2005: Scott Houghtaling; Laura Granville; Yassmine Akkari; Yumi Torimaru; Susan B Olson; Milton Finegold; Markus Grompe
Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice.
Cancer research 2005;65(1):85-91.
2004: Holger Willenbring; Markus Grompe
Delineating the hepatocyte's hematopoietic fusion partner.
Cell cycle (Georgetown, Tex.) 2004;3(12):1489-91.
2004: Marjanka C Luijerink; Ellen A C M van Beurden; Helga E M Malingré; Saskia M M Jacobs; Markus Grompe; Leo W J Klomp; Ruud Berger; Inge E T van den Berg
Renal proximal tubular cells acquire resistance to cell death stimuli in mice with hereditary tyrosinemia type 1.
Kidney international 2004;66(3):990-1000.
2004: Holger Willenbring; Alexis S Bailey; Mark Foster; Yassmine Akkari; Craig Dorrell; Susan B Olson; Milton Finegold; William H Fleming; Markus Grompe
Myelomonocytic cells are sufficient for therapeutic cell fusion in liver.
Nature medicine 2004;10(7):744-8.
2004: Amy E Hanlon Newell; Yassmine Akkari; Yumi Torimaru; Andrew Rosenthal; Carol A Reifsteck; Barbara Cox; Markus Grompe; Susan B Olson
Interstrand crosslink-induced radials form between non-homologous chromosomes, but are absent in sex chromosomes.
DNA repair 2004;3(5):535-42.
2004: Maneesh Gupta; Erwin E W Jansen; Henry Senephansiri; Cornelis Jakobs; O Carter Snead; Markus Grompe; K Michael Gibson
Liver-directed adenoviral gene transfer in murine succinate semialdehyde dehydrogenase deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(4):527-39.
2004: Gillian Turner; Karen M Lower; S M White; Martin B Delatycki; Anne K Lampe; M Wright; J Clayton Smith; Bronwyn Kerr; Susan Schelley; H Eugene Hoyme; Bert B A de Vries; Tjitske Kleefstra; Markus Grompe; B Cox; Jozef Gecz; Michael Partington
The clinical picture of the Börjeson-Forssman-Lehmann syndrome in males and heterozygous females with PHF6 mutations.
Clinical genetics 2004;65(3):226-32.
2004: Arndt Vogel; Inge E T van den Berg; Muhsen Al-Dhalimy; John Groopman; Ching-Nan Ou; Olga Ryabinina; Mihail S Iordanov; Milton Finegold; Markus Grompe
Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death.
Hepatology (Baltimore, Md.) 2004;39(2):433-43.
2004: Markus Grompe
The importance of knowing your identity: sources of confusion in stem cell biology.
Hepatology (Baltimore, Md.) 2004;39(1):35-7.
2004: Andreas Rothfuss; Markus Grompe
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway.
Molecular and cellular biology 2004;24(1):123-34.
2003: Shinjiro Akaboshi; Boris M Hogema; Andrea Novelletto; Patrizia Malaspina; Gajja S Salomons; George D Maropoulos; Cornelis Jakobs; Markus Grompe; K Michael Gibson
Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency.
Human mutation 2003;22(6):442-50.
2003: Chandramohan V Ammini; Jose Fernandez-Canon; Albert L Shroads; Rachel Cornett; Jang Cheung; Margaret O James; George N Henderson; Markus Grompe; Peter W Stacpoole
Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.
Biochemical pharmacology 2003;66(10):2029-38.
2003: Markus Grompe
The role of bone marrow stem cells in liver regeneration.
Seminars in liver disease 2003;23(4):363-72.
2003: Holger Willenbring; Markus Grompe
Embryonic versus adult stem cell pluripotency: in liver only fusion matters.
Journal of assisted reproduction and genetics 2003;20(10):393-4.
2003: Xin Wang; Mark Foster; Muhsen Al-Dhalimy; Eric Lagasse; Milton Finegold; Markus Grompe
The origin and liver repopulating capacity of murine oval cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100 Suppl 1():11881-8.
2003: Scott Houghtaling; Cynthia Timmers; Meenakshi Noll; Milton J Finegold; Stephen N Jones; M Stephen Meyn; Markus Grompe
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice.
Genes & development 2003;17(16):2021-35.
2003: Hiroyuki Nakai; Eugenio Montini; Sally Fuess; Theresa A Storm; Markus Grompe; Mark A Kay
AAV serotype 2 vectors preferentially integrate into active genes in mice.
Nature genetics 2003;34(3):297-302.
2003: Maria Pia Cosma; Stefano Pepe; Ida Annunziata; Robert F Newbold; Markus Grompe; Giancarlo Parenti; Andrea Ballabio
The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases.
Cell 2003;113(4):445-56.
2003: Xin Wang; Holger Willenbring; Yassmine Akkari; Yumi Torimaru; Mark Foster; Muhsen Al-Dhalimy; Eric Lagasse; Milton Finegold; Susan B Olson; Markus Grompe
Cell fusion is the principal source of bone-marrow-derived hepatocytes.
Nature 2003;422(6934):897-901.
2003: Maneesh Gupta; Boris M Hogema; Markus Grompe; Teodoro Bottiglieri; Alessandra Concas; Giovanni Biggio; Cristiana Sogliano; Antonello E Rigamonti; Phillip L Pearl; O Carter Snead; Cornelis Jakobs; K Michael Gibson
Murine succinate semialdehyde dehydrogenase deficiency.
Annals of neurology 2003;54 Suppl 6():S81-90.
2003: Hiroyuki Nakai; Eugenio Montini; Sally Fuess; Theresa A Storm; Leonard Meuse; Milton Finegold; Markus Grompe; Mark A Kay
Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(1):101-11.
2003: Alan D D'Andrea; Markus Grompe
The Fanconi anaemia/BRCA pathway.
Nature reviews. Cancer 2003;3(1):23-34.
2003: Markus Grompe
Pancreatic-hepatic switches in vivo.
Mechanisms of development 2003;120(1):99-106.
2002: Eugenio Montini; Patrice K Held; Meenakshi Noll; Nicolas Morcinek; Muhsen Al-Dhalimy; Milton Finegold; Stephen R Yant; Mark A Kay; Markus Grompe
In vivo correction of murine tyrosinemia type I by DNA-mediated transposition.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(6):759-69.
2002: Karen M Lower; Gillian Turner; Bronwyn A Kerr; Katherine D Mathews; Marie A Shaw; Agi K Gedeon; Susan Schelley; H Eugene Hoyme; Susan M White; Martin B Delatycki; Anne K Lampe; Jill Clayton-Smith; Helen Stewart; Conny M A van Ravenswaay; Bert B A de Vries; Barbara Cox; Markus Grompe; Shelley Ross; Paul Thomas; John C Mulley; Jozef Gécz
Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome.
Nature genetics 2002;32(4):661-5.
2002: Peter Kurre; Ponni Anandakumar; Markus Grompe; Hans-Peter Kiem
In vivo administration of interferon gamma does not cause marrow aplasia in mice with a targeted disruption of FANCC.
Experimental hematology 2002;30(11):1257-62.
2002: Francesco Galimi; Meenakshi Noll; Yoshiyuki Kanazawa; Timothy Lax; Cindy Chen; Markus Grompe; Inder M Verma
Gene therapy of Fanconi anemia: preclinical efficacy using lentiviral vectors.
Blood 2002;100(8):2732-6.
2002: Alexandra Folias; Mara Matkovic; Donald Bruun; Sonja Reid; James Hejna; Markus Grompe; Alan D D'Andrea; Robb Moses
BRCA1 interacts directly with the Fanconi anemia protein FANCA.
Human molecular genetics 2002;11(21):2591-7.
2002: Toshiyasu Taniguchi; Irene Garcia-Higuera; Paul R Andreassen; Richard C. Gregory; Markus Grompe; Alan D D'Andrea
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
Blood 2002;100(7):2414-20.
2002: Markus Grompe
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. 1991.
Journal of hepatology 2002;37(4):422-4.
2002: Markus Grompe
Adult versus embryonic stem cells: it's still a tie.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):303-5.
2002: Xin Wang; Eugenio Montini; Muhsen Al-Dhalimy; Eric Lagasse; Milton Finegold; Markus Grompe
Kinetics of liver repopulation after bone marrow transplantation.
The American journal of pathology 2002;161(2):565-74.
2002: Niall G Howlett; Toshiyasu Taniguchi; Susan B Olson; Barbara Cox; Quinten Waisfisz; C E M de Die-Smulders; Nicole Persky; Markus Grompe; Hans Joenje; Gerard Pals; Hideyuki Ikeda; Edward A Fox; Alan D D'Andrea
Biallelic inactivation of BRCA2 in Fanconi anemia.
Science (New York, N.Y.) 2002;297(5581):606-9.
2002: Martin Digweed; Ilja Demuth; Susanne Rothe; Regina Scholz; Andreas Jordan; Carsten Grötzinger; Detlev Schindler; Markus Grompe; Karl Sperling
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11.
Oncogene 2002;21(32):4873-8.
2002: Meenakshi Noll; Kevin P Battaile; Raynard Bateman; Timothy P Lax; Keany Rathbun; Carol A Reifsteck; Grover C Bagby; Milton Finegold; Susan B Olson; Markus Grompe
Fanconi anemia group A and C double-mutant mice: functional evidence for a multi-protein Fanconi anemia complex.
Experimental hematology 2002;30(7):679-88.
2002: Martin Digweed; Susanne Rothe; Ilja Demuth; Regina Scholz; Detlev Schindler; Markus Stumm; Markus Grompe; Andreas Jordan; Karl Sperling
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.
Carcinogenesis 2002;23(7):1121-6.
2002: Maneesh Gupta; Rachel Greven; Erwin E W Jansen; Cornelis Jakobs; Boris M Hogema; Wolfgang Froestl; O Carter Snead; Hilke Bartels; Markus Grompe; K Michael Gibson
Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria).
The Journal of pharmacology and experimental therapeutics 2002;302(1):180-7.
2002: José Manuel Fernández-Cañón; Manfred W Baetscher; Milton Finegold; Terry Burlingame; K Michael Gibson; Markus Grompe
Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism.
Molecular and cellular biology 2002;22(13):4943-51.
2002: Stephen F Badylak; Markus Grompe; Arnold I Caplan; Howard P Greisler; Robert E Guldberg; Doris Taylor
In vivo remodeling: breakout session summary.
Annals of the New York Academy of Sciences 2002;961():319-22.
2002: Markus Grompe
Transition of stem cells to therapeutically functional tissue-specific cells.
Annals of the New York Academy of Sciences 2002;961():305-6.
2002: Markus Grompe
FANCD2: a branch-point in DNA damage response?
Nature medicine 2002;8(6):555-6.
2002: K Michael Gibson; D S M Schor; Maneesh Gupta; W S Guerand; Henry Senephansiri; Terry Burlingame; H Bartels; Boris M Hogema; Teodoro Bottiglieri; Wolfgang Froestl; O Carter Snead; Markus Grompe; Cornelis Jakobs
Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase.
Journal of neurochemistry 2002;81(1):71-9.
2002: Humberto E Soriano; Markus Grompe
Gene therapy and pediatric liver disease.
Journal of pediatric gastroenterology and nutrition 2002;35 Suppl 1():S51-4.
2002: Muhsen Al-Dhalimy; K Overturf; Milton Finegold; Markus Grompe
Long-term therapy with NTBC and tyrosine-restricted diet in a murine model of hereditary tyrosinemia type I.
Molecular genetics and metabolism 2002;75(1):38-45.
2001: M A Siddique; Koji Nakanishi; Toshiyasu Taniguchi; Markus Grompe; Alan D D'Andrea
Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells.
Experimental hematology 2001;29(12):1448-55.
2001: Yassmine Akkari; Raynard Bateman; Carol A Reifsteck; Alan D D'Andrea; Susan B Olson; Markus Grompe
The 4N cell cycle delay in Fanconi anemia reflects growth arrest in late S phase.
Molecular genetics and metabolism 2001;74(4):403-12.
2001: Markus Grompe
The pathophysiology and treatment of hereditary tyrosinemia type 1.
Seminars in liver disease 2001;21(4):563-71.
2001: Markus Grompe; Alan D D'Andrea
Fanconi anemia and DNA repair.
Human molecular genetics 2001;10(20):2253-9.
2001: Boris M Hogema; Maneesh Gupta; Henry Senephansiri; Terry Burlingame; M Taylor; Cornelis Jakobs; RB Schutgens; Wolfgang Froestl; O Carter Snead; Ramon Diaz-Arrastia; Teodoro Bottiglieri; Markus Grompe; K Michael Gibson
Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase.
Nature genetics 2001;29(2):212-6.
2001: A N Karnezis; M Dorokhov; Markus Grompe; Liang Zhu
Loss of p27(Kip1) enhances the transplantation efficiency of hepatocytes transferred into diseased livers.
The Journal of clinical investigation 2001;108(3):383-90.
2001: Koji Nakanishi; A Moran; T Hays; Yanan Kuang; E Fox; D Garneau; Rocio Montes de Oca; Markus Grompe; Alan D D'Andrea
Functional analysis of patient-derived mutations in the Fanconi anemia gene, FANCG/XRCC9.
Experimental hematology 2001;29(7):842-9.
2001: R L Bateman; Pullooru Bhanumoorthy; John F Witte; Ronald W McClard; Markus Grompe; David E Timm
Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor.
The Journal of biological chemistry 2001;276(18):15284-91.
2001: Richard G H Cotton; Markus Grompe
Chemical cleavage of heteroduplex DNA to identify mutations.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2001;Chapter 7():Unit 7.6.
2001: Markus Grompe
Liver repopulation for the treatment of metabolic diseases.
Journal of inherited metabolic disease 2001;24(2):231-44.
2001: Markus Grompe
Mouse liver goes human: a new tool in experimental hepatology.
Hepatology (Baltimore, Md.) 2001;33(4):1005-6.
2001: Boris M Hogema; Shinjiro Akaboshi; M Taylor; Gajja S Salomons; Cornelis Jakobs; RB Schutgens; B Wilcken; S Worthington; George D Maropoulos; Markus Grompe; K Michael Gibson
Prenatal diagnosis of succinic semialdehyde dehydrogenase deficiency: increased accuracy employing DNA, enzyme, and metabolite analyses.
Molecular genetics and metabolism 2001;72(3):218-22.
2001: Irene Garcia-Higuera; Toshiyasu Taniguchi; S Ganesan; M Stephen Meyn; Cynthia Timmers; James Hejna; Markus Grompe; Alan D D'Andrea
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
Molecular cell 2001;7(2):249-62.
2001: Cynthia Timmers; Toshiyasu Taniguchi; James Hejna; Carol A Reifsteck; L Lucas; Donald Bruun; Mathew J Thayer; Barbara Cox; Susan B Olson; Alan D D'Andrea; Robb Moses; Markus Grompe
Positional cloning of a novel Fanconi anemia gene, FANCD2.
Molecular cell 2001;7(2):241-8.
2001: Xin Wang; Muhsen Al-Dhalimy; Eric Lagasse; Milton Finegold; Markus Grompe
Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells.
The American journal of pathology 2001;158(2):571-9.
2001: Meenakshi Noll; Raynard Bateman; Alan D D'Andrea; Markus Grompe
Preclinical protocol for in vivo selection of hematopoietic stem cells corrected by gene therapy in Fanconi anemia group C.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(1):14-23.
2000: Eric Lagasse; H Connors; Muhsen Al-Dhalimy; M Reitsma; M Dohse; L Osborne; Xin Wang; Milton Finegold; I L Weissman; Markus Grompe
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo.
Nature medicine 2000;6(11):1229-34.
2000: Yassmine Akkari; Raynard Bateman; Carol A Reifsteck; Susan B Olson; Markus Grompe
DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links.
Molecular and cellular biology 2000;20(21):8283-9.
2000: S Volarevic; M J Stewart; B Ledermann; F Zilberman; L Terracciano; Eugenio Montini; Markus Grompe; Sara C Kozma; George Thomas
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.
Science (New York, N.Y.) 2000;288(5473):2045-7.
2000: James Hejna; Cynthia Timmers; Carol A Reifsteck; Donald Bruun; L W Lucas; Petra Jakobs; S Toth-Fejel; N Unsworth; S L Clemens; DK Garcia; Susan Naylor; Mathew J Thayer; Susan B Olson; Markus Grompe; Robb Moses
Localization of the Fanconi anemia complementation group D gene to a 200-kb region on chromosome 3p25.3.
American journal of human genetics 2000;66(5):1540-51.
2000: K A Gush; KL Fu; Markus Grompe; Christopher E Walsh
Phenotypic correction of Fanconi anemia group C knockout mice.
Blood 2000;95(2):700-4.
1999: Markus Grompe
Therapeutic liver repopulation for the treatment of metabolic liver diseases.
Human cell 1999;12(4):171-80.
1999: K Overturf; Muhsen Al-Dhalimy; Milton Finegold; Markus Grompe
The repopulation potential of hepatocyte populations differing in size and prior mitotic expansion.
The American journal of pathology 1999;155(6):2135-43.
1999: K Manning; Muhsen Al-Dhalimy; Milton Finegold; Markus Grompe
In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11928-33.
1999: Kevin P Battaile; Raynard Bateman; D Mortimer; Jean Marie Mulcahy Levy; R Keaney Rathbun; Grover C Bagby; William H Fleming; Markus Grompe
In vivo selection of wild-type hematopoietic stem cells in a murine model of Fanconi anemia.
Blood 1999;94(6):2151-8.
1999: José Manuel Fernández-Cañón; James Hejna; Carol A Reifsteck; Susan B Olson; Markus Grompe
Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase.
Genomics 1999;58(3):263-9.
1999: Petra Jakobs; L Smith; Mathew J Thayer; Markus Grompe
Embryonic stem cells can be used to construct hybrid cell lines containing a single, selectable murine chromosome.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(4):381-4.
1999: Tetsuya Otsuki; Shoichi Nagakura; Jin Wang; M Bloom; Markus Grompe; Johnson Ming-Yu Liu
Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice.
Journal of cellular physiology 1999;179(1):79-86.
1999: Markus Grompe; Ezio Laconi; David A Shafritz
Principles of therapeutic liver repopulation.
Seminars in liver disease 1999;19(1):7-14.
1999: K Manning; José Manuel Fernández-Cañón; X Montagutelli; Markus Grompe
Identification of the mutation in the alkaptonuria mouse model. Mutations in brief no. 216. Online.
Human mutation 1999;13(2):171.
1998: Markus Grompe; K Overturf; Muhsen Al-Dhalimy; Milton Finegold
Therapeutic trials in the murine model of hereditary tyrosinaemia type I: a progress report.
Journal of inherited metabolic disease 1998;21(5):518-31.
1998: Michael Allen Pulsipher; Gary M Kupfer; D Naf; A Suliman; J S Lee; Petra Jakobs; Markus Grompe; Hans Joenje; Colin A Sieff; Eva C Guinan; R Mulligan; Alan D D'Andrea
Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer.
Molecular medicine (Cambridge, Mass.) 1998;4(7):468-79.
1998: K Overturf; Muhsen Al-Dhalimy; K Manning; Ching-Nan Ou; Milton Finegold; Markus Grompe
Ex vivo hepatic gene therapy of a mouse model of Hereditary Tyrosinemia Type I.
Human gene therapy 1998;9(3):295-304.
1998: Michael C Heinrich; Maureen Hoatlin; AJ Zigler; KV Silvey; Antony C (Tony) Bakke; Winifred Keeble; Yu Zhi; Carol A Reifsteck; Markus Grompe; M G Brown; R Ellen Magenis; Susan B Olson; Grover C Bagby
DNA cross-linker-induced G2/M arrest in group C Fanconi anemia lymphoblasts reflects normal checkpoint function.
Blood 1998;91(1):275-87.
1997: K Overturf; Muhsen Al-Dhalimy; Ching-Nan Ou; Milton Finegold; Markus Grompe
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.
The American journal of pathology 1997;151(5):1273-80.
1997: Alan D D'Andrea; Markus Grompe
Molecular biology of Fanconi anemia: implications for diagnosis and therapy.
Blood 1997;90(5):1725-36.
1997: R Keaney Rathbun; Gregory R Faulkner; M H Ostroski; Tracy A Christianson; G Hughes; G Jones; R Cahn; Richard T Maziarz; G Royle; Winifred Keeble; Michael C Heinrich; Markus Grompe; PA Tower; Grover C Bagby
Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells.
Blood 1997;90(3):974-85.
1997: K Overturf; Muhsen Al-Dhalimy; Ching-Nan Ou; Milton Finegold; R Tanguay; A Lieber; M Kay; Markus Grompe
Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I.
Human gene therapy 1997;8(5):513-21.
1997: Petra Jakobs; E Fiddler-Odell; Carol A Reifsteck; Susan B Olson; Robb Moses; Markus Grompe
Complementation group assignments in Fanconi anemia fibroblast cell lines from North America.
Somatic cell and molecular genetics 1997;23(1):1-7.
1996: M A Whitney; G Royle; Malcolm J Low; M A Kelly; Michael K Axthelm; Carol A Reifsteck; Susan B Olson; R E Braun; Michael C Heinrich; R Keaney Rathbun; Grover C Bagby; Markus Grompe
Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene.
Blood 1996;88(1):49-58.
1996: Takayuki Yamashita; N Wu; Gary M Kupfer; Christopher L Corless; Hans Joenje; Markus Grompe; Alan D D'Andrea
Clinical variability of Fanconi anemia (type C) results from expression of an amino terminal truncated Fanconi anemia complementation group C polypeptide with partial activity.
Blood 1996;87(10):4424-32.
1996: Petra Jakobs; P Sahaayaruban; H Saito; Carol A Reifsteck; Susan B Olson; Hans Joenje; Robb Moses; Markus Grompe
Immortalization of four new Fanconi anemia fibroblast cell lines by an improved procedure.
Somatic cell and molecular genetics 1996;22(2):151-7.
1996: K Overturf; Muhsen Al-Dhalimy; R Tanguay; M Brantly; Ching-Nan Ou; Milton Finegold; Markus Grompe
Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I.
Nature genetics 1996;12(3):266-73.
1996: Cynthia Timmers; Markus Grompe
Six novel mutations in the fumarylacetoacetate hydrolase gene of patients with hereditary tyrosinemia type I.
Human mutation 1996;7(4):367-9.
1996: Susan Naylor; B Carritt; catherine boileau; C Beroud; C Alexander; P Allderdice; A Alimov; T Ashworth; J Bonifas; P Bugert; Charles H C M Buys; M A Chipperfield; G Deng; Harry A Drabkin; Robert M Gemmill; Markus Grompe; T Joensuu; A Jonasdottir; Rinat Z Gizatullin; Luc Krols; Robin J Leach; Steven Lott; Ann McNeill Killary; T Martinsson; Ludwine MESSIAEN
Report of the sixth international workshop on human chromosome 3 mapping 1995.
Cytogenetics and cell genetics 1996;72(4):255-70.
1995: M Whitney; Mathew J Thayer; Carol A Reifsteck; Susan B Olson; L Smith; Petra Jakobs; Robin J Leach; Susan Naylor; Hans Joenje; Markus Grompe
Microcell mediated chromosome transfer maps the Fanconi anaemia group D gene to chromosome 3p.
Nature genetics 1995;11(3):341-3.
1995: F Quan; Markus Grompe; Petra Jakobs; B W Popovich
Spontaneous deletion in the FMR1 gene in a patient with fragile X syndrome and cherubism.
Human molecular genetics 1995;4(9):1681-4.
1995: James Hejna; H Saito; Louise S Merkens; T V Tittle; Petra Jakobs; M A Whitney; Markus Grompe; A S Friedberg; Robb Moses
Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases.
Genomics 1995;29(1):285-7.
1995: Markus Grompe; S Lindstedt; Muhsen Al-Dhalimy; N G Kennaway; John Papaconstantinou; Carlos A Torres-Ramos; Ching-Nan Ou; Milton Finegold
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.
Nature genetics 1995;10(4):453-60.
1995: Markus Grompe; Muhsen Al-Dhalimy
Rapid nonradioactive assay for the detection of the common French Canadian tyrosinemia type I mutation.
Human mutation 1995;5(1):105.
1994: Edward Hasty; M Crist; Markus Grompe; Allan Bradley
Efficiency of insertion versus replacement vector targeting varies at different chromosomal loci.
Molecular and cellular biology 1994;14(12):8385-90.
1994: Markus Grompe; M St-Louis; S I Demers; Muhsen Al-Dhalimy; B Leclerc; Robert M Tanguay
A single mutation of the fumarylacetoacetate hydrolase gene in French Canadians with hereditary tyrosinemia type I.
The New England journal of medicine 1994;331(6):353-7.
1994: Christopher E Walsh; Markus Grompe; E Vanin; M Buchwald; Neal S Young; A W Nienhuis; Johnson Ming-Yu Liu
A functionally active retrovirus vector for gene therapy in Fanconi anemia group C.
Blood 1994;84(2):453-9.
1994: H Saito; Markus Grompe; T L Neeley; Petra Jakobs; Robb Moses
Fanconi anemia cells have a normal gene structure for topoisomerase I.
Human genetics 1994;93(5):583-6.
1994: Elizabeth Lindsay; A Grillo; GB Ferrero; E J Roth; E Magenis; Markus Grompe; M Hultén; C Gould; Antonio Baldini; Huda Y Zoghbi
Microphthalmia with linear skin defects (MLS) syndrome: clinical, cytogenetic, and molecular characterization.
American journal of medical genetics 1994;49(2):229-34.
1994: M A Whitney; Petra Jakobs; M Kaback; Robb Moses; Markus Grompe
The Ashkenazi Jewish Fanconi anemia mutation: incidence among patients and carrier frequency in the at-risk population.
Human mutation 1994;3(4):339-41.
1993: Markus Grompe; Muhsen Al-Dhalimy; Milton Finegold; Ching-Nan Ou; T Burlingame; N G Kennaway; P Soriano
Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice.
Genes & development 1993;7(12A):2298-307.
1993: Markus Grompe
The rapid detection of unknown mutations in nucleic acids.
Nature genetics 1993;5(2):111-7.
1993: M A Whitney; H Saito; Petra Jakobs; R A Gibson; Robb Moses; Markus Grompe
A common mutation in the FACC gene causes Fanconi anaemia in Ashkenazi Jews.
Nature genetics 1993;4(2):202-5.
1993: Markus Grompe; Muhsen Al-Dhalimy
Mutations of the fumarylacetoacetate hydrolase gene in four patients with tyrosinemia, type I.
Human mutation 1993;2(2):85-93.
1992: Markus Grompe; Muhsen Al-Dhalimy
Nucleotide sequence of a cDNA encoding murine fumarylacetoacetate hydrolase.
Biochemical medicine and metabolic biology 1992;48(1):26-31.
1992: M W Kilimann; Antonio Pizzuti; Markus Grompe; CT Caskey
Point mutations and polymorphisms in the human dystrophin gene identified in genomic DNA sequences amplified by multiplex PCR.
Human genetics 1992;89(3):253-8.
1992: Markus Grompe; M Pieretti; CT Caskey; A Ballabio
The sulfatase gene family: cross-species PCR cloning using the MOPAC technique.
Genomics 1992;12(4):755-60.
1992: E Basler; Markus Grompe; Giancarlo Parenti; J Yates; A Ballabio
Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis.
American journal of human genetics 1992;50(3):483-91.
1992: Markus Grompe; Stephen N Jones; H Loulseged; CT Caskey
Retroviral-mediated gene transfer of human ornithine transcarbamylase into primary hepatocytes of spf and spf-ash mice.
Human gene therapy 1992;3(1):35-44.
1992: Markus Grompe; N Rao; Frederick F Elder; CT Caskey; F Greenberg
45,X/46,X,+r(X) can have a distinct phenotype different from Ullrich-Turner syndrome.
American journal of medical genetics 1992;42(1):39-43.
1991: H Zheng; Edward Hasty; M A Brenneman; Markus Grompe; Richard A Gibbs; John H Wilson; Allan Bradley
Fidelity of targeted recombination in human fibroblasts and murine embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8067-71.
1991: Giuseppe Borsani; R Tonlorenzi; M C Simmler; L Dandolo; Danielle Arnaud; V Capra; Markus Grompe; Antonio Pizzuti; Donna M Muzny; C Lawrence; H F Willard; P Avner; A Ballabio
Characterization of a murine gene expressed from the inactive X chromosome.
Nature 1991;351(6324):325-9.
1991: Markus Grompe; James Versalovic; T Koeuth; James R Lupski
Mutations in the Escherichia coli dnaG gene suggest coupling between DNA replication and chromosome partitioning.
Journal of bacteriology 1991;173(3):1268-78.
1991: Markus Grompe; CT Caskey; R G Fenwick
Improved molecular diagnostics for ornithine transcarbamylase deficiency.
American journal of human genetics 1991;48(2):212-22.
1991: Carolyn J Brown; A Ballabio; J L Rupert; R G Lafreniere; Markus Grompe; R Tonlorenzi; Huntington F Willard
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome.
Nature 1991;349(6304):38-44.
1991: Markus Grompe; K Mitani; Cheng Chi Lee; Stephen N Jones; CT Caskey
Gene therapy in man and mice: adenosine deaminase deficiency, ornithine transcarbamylase deficiency, and Duchenne muscular dystrophy.
Advances in experimental medicine and biology 1991;309B():51-6.
1990: Markus Grompe; Stephen N Jones; CT Caskey
Molecular detection and correction of ornithine transcarbamylase deficiency.
Trends in genetics : TIG 1990;6(10):335-9.
1990: Stephen N Jones; Markus Grompe; M I Munir; Gabor Veres; William J Craigen; CT Caskey
Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice.
The Journal of biological chemistry 1990;265(24):14684-90.
1989: Markus Grompe; R A Gibbs; J S Chamberlain; C T Caskey
Detection of new mutation disease in man and mouse.
Molecular biology & medicine 1989;6(6):511-21.
1989: Markus Grompe; Donna M Muzny; CT Caskey
Scanning detection of mutations in human ornithine transcarbamoylase by chemical mismatch cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5888-92.
1985: Markus Grompe; L Kreja; J Schmidt; H J Seidel
RNA virus expression during and after methylnitrosourea-induced T-cell leukemogenesis in mice.
Blut 1985;51(6):377-84.
1984: W Vogel; Markus Grompe; R Storz; S Pentz
A comparative study on steroid sulfatase and arylsulfatase C in fibroblast clones from 45,X/47,XXX and 69,XXY.
Human genetics 1984;66(4):367-9.