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Luis Botana

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Juan A Rubiolo; Félix V Vega; Mercedes Rodríguez Vieytes; Amparo Alfonso; Henar López-Alonso; Luis Botana
Bioengineered protein phosphatase 2A: update on need.
Eva Alonso; Alvaro Antelo; Amparo Alfonso; Laurent Chabaud; Lydia Giménez-Llort; Catherine Guillou; Paz Otero; Carmen Vale; Luis Botana
Benefit of 13-desmethyl Spirolide C Treatment in Triple Transgenic Mouse Model of Alzheimer Disease: Beta-Amyloid and Neuronal Markers Improvement.
Laura P Rodríguez; Todd Talley; Palmer Taylor; Natalia Vilariño; Rómulo Aráoz; M Carmen Louzao; Jordi Molgó; Luis Botana
Development of a solid-phase receptor-based assay for the detection of cyclic imines using a microsphere-flow cytometry system.

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2013: Juan A Rubiolo; Félix V Vega; Mercedes Rodríguez Vieytes; Amparo Alfonso; Henar López-Alonso; Luis Botana
Bioengineered protein phosphatase 2A: update on need.
Bioengineered 2013;4(2):72-7.
2013: Eva Alonso; Alvaro Antelo; Amparo Alfonso; Laurent Chabaud; Lydia Giménez-Llort; Catherine Guillou; Paz Otero; Carmen Vale; Luis Botana
Benefit of 13-desmethyl Spirolide C Treatment in Triple Transgenic Mouse Model of Alzheimer Disease: Beta-Amyloid and Neuronal Markers Improvement.
Current Alzheimer research 2013;10(3):279-89.
2013: Laura P Rodríguez; Todd Talley; Palmer Taylor; Natalia Vilariño; Rómulo Aráoz; M Carmen Louzao; Jordi Molgó; Luis Botana
Development of a solid-phase receptor-based assay for the detection of cyclic imines using a microsphere-flow cytometry system.
Analytical chemistry 2013;85(4):2340-7.
2013: Henar López-Alonso; Juan Andrés Rubiolo; Félix Vega; Mercedes R Vieytes; Luis Botana
Protein synthesis inhibition and oxidative stress induced by cylindrospermopsin elicit apoptosis in primary rat hepatocytes.
Chemical research in toxicology 2013;26(2):203-12.
2012: Rómulo Aráoz; Evelyne Benoit; Luis Botana; Vincent Guérineau; Franck Pelissier; Suzanne Ramos; Natalia Vilariño; Armen Zakarian; Jordi Molgó
Coupling the Torpedo microplate-receptor binding assay with mass spectrometry to detect cyclic imine neurotoxins.
Analytical chemistry 2012;84(23):10445-53.
2012: Araceli Tobío; Andrea Fernández-Araujo; Amparo Alfonso; Luis Botana
Role of yessotoxin in calcium and cAMP-crosstalks in primary and K-562 human lymphocytes: the effect is mediated by anchor kinase A mitochondrial proteins.
Journal of cellular biochemistry 2012;113(12):3752-61.
2012: Sheila Pérez; Makoto Sasaki; Yuto Suga; Carmen Vale; Mercedes R Vieytes; Eva Alonso; Haruhiko Fuwa; Tomomi Goto; Yu Konno; Luis Botana
Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: a structure-activity relationships study.
Chemical research in toxicology 2012;25(9):1929-37.
2012: Luis Botana
A perspective on the toxicology of marine toxins.
Chemical research in toxicology 2012;25(9):1800-4.
2012: J A Rubiolo; F V Vega; M R Vieytes; A Alfonso; H López-Alonso; Luis Botana
Characterization and activity determination of the human protein phosphatase 2A catalytic subunit α expressed in insect larvae.
Applied biochemistry and biotechnology 2012;167(4):918-28.
2012: María Fraga; Kentaro Kawatsu; M Carmen Louzao; Mercedes R Vieytes; Natalia Vilariño; Katrina Campbell; Christopher T Elliott; Luis Botana
Detection of paralytic shellfish toxins by a solid-phase inhibition immunoassay using a microsphere-flow cytometry system.
Analytical chemistry 2012;84(10):4350-6.
2012: Eva Alonso; Haruhiko Fuwa; Lydia Giménez-Llort; Tomomi Goto; Yu Konno; Frank M LaFerla; Makoto Sasaki; Yuto Suga; Carmen Vale; Mercedes R Vieytes; Luis Botana
Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications.
Journal of the American Chemical Society 2012;134(17):7467-79.
2012: A Alfonso; C Alfonso; B Caramés; A Fernández-Araujo; M C Louzao; A Tobio; M R Vieytes; Luis Botana
Palytoxin detection and quantification using the fluorescence polarization technique.
Analytical biochemistry 2012;424(1):64-70.
2012: Marisa Silva; Amparo Alfonso; Joana Azevedo; Luis Botana; Paula Rodriguez; Vitor Vasconcelos
New gastropod vectors and tetrodotoxin potential expansion in temperate waters of the Atlantic Ocean.
Marine drugs 2012;10(4):712-26.
2012: J A Rubiolo; F V Vega; M R Vieytes; H López-Alonso; Luis Botana
Comparative study of toxicological and cell cycle effects of okadaic acid and dinophysistoxin-2 in primary rat hepatocytes.
Life sciences 2012;90(11-12):416-23.
2012: Paz Otero; Paula Rodríguez; Juan A Rubiolo; Mercedes R Vieytes; Amparo Alfonso; Roberto Bermúdez; José Manuel Cifuentes; Luis Botana
Pharmacokinetic and toxicological data of spirolides after oral and intraperitoneal administration.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(2):232-7.
2012: J A Rubiolo; H López-Alonso; V Martín-Vázquez; M R Vieytes; Luis Botana; N M Fol-Rodríguéz; F V Vega
Resveratrol inhibits proliferation of primary rat hepatocytes in G0/G1 by inhibiting DNA synthesis.
Folia biologica 2012;58(4):166-72.
2011: Luis Botana; Antonio J Mota; Antonio Rodríguez-Diéguez; José Ruiz; José Manuel Seco; Reijo Sillanpää; Enrique Colacio
Influence of the anions on the structure and magnetic properties of a series of bis(μ-diphenoxo)-bridged linear trinuclear copper(II) complexes: an experimental and theoretical study.
Dalton transactions (Cambridge, England : 2003) 2011;40(46):12462-71.
2011: Judith K Nzoughet; Paulo A Prodöhl; Luis Botana; Irene R Grant; John T G Hamilton; Christopher T Elliott
Evidence of Methylobacterium spp. and Hyphomicrobium sp. in azaspiracid toxin contaminated mussel tissues and assessment of the effect of azaspiracid on their growth.
Toxicon : official journal of the International Society on Toxinology 2011;58(8):619-22.
2011: Eva Alonso; Lydia Giménez-Llort; Frank M LaFerla; Carmen Vale; Mercedes R Vieytes; Luis Botana
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Neurochemistry international 2011;59(7):1056-65.
2011: J A Rubiolo; F V Vega; Mercedes R Vieytes; H López-Alonso; Luis Botana
Okadaic acid and dinophysis toxin 2 have differential toxicological effects in hepatic cell lines inducing cell cycle arrest, at G0/G1 or G2/M with aberrant mitosis depending on the cell line.
Archives of toxicology 2011;85(12):1541-50.
2011: Paz Otero; Mercedes R Vieytes; Jordi Molgó; Amparo Alfonso; Carmen Alfonso; Rómulo Aráoz; Luis Botana
First direct fluorescence polarization assay for the detection and quantification of spirolides in mussel samples.
Analytica chimica acta 2011;701(2):200-8.
2011: Begoña Espiña; M Carmen Louzao; Paz Otero; Amparo Alfonso; Luis Botana
13-Desmethyl spirolide-c and 13,19-didesmethyl spirolide-c trans-epithelial permeabilities: human intestinal permeability modelling.
Toxicology 2011;287(1-3):69-75.
2011: Araceli Tobío; Amparo Alfonso; Luis Botana
C-kit mutations and PKC crosstalks: PKC translocates to nucleous only in cells HMC⁵⁶⁰,⁸¹⁶.
Journal of cellular biochemistry 2011;112(9):2637-51.
2011: Laura P Rodríguez; Mercedes R Vieytes; Natalia Vilariño; Alvaro Antelo; Rómulo Aráoz; Jordi Molgó; Luis Botana
Solid-phase receptor-based assay for the detection of cyclic imines by chemiluminescence, fluorescence, or colorimetry.
Analytical chemistry 2011;83(15):5857-63.
2011: Paz Otero; Paula Rodríguez; Mercedes R Vieytes; Amparo Alfonso; Carmen Alfonso; Luis Botana
Effect of uncontrolled factors in a validated liquid chromatography-tandem mass spectrometry method question its use as a reference method for marine toxins: major causes for concern.
Analytical chemistry 2011;83(15):5903-11.
2011: Sheila Perez; Carmen Vale; Mercedes R Vieytes; Eva Alonso; Ana M Botana; Luis Botana
Determination of toxicity equivalent factors for paralytic shellfish toxins by electrophysiological measurements in cultured neurons.
Chemical research in toxicology 2011;24(7):1153-7.
2011: Eva Cagide; B Espiña; Haruhiko Fuwa; Y Konno; M Carmen Louzao; Leo A Paquette; M Sasaki; C Tsukano; Mercedes R Vieytes; Takeshi Yasumoto; Mari Yotsu-Yamashita; Isabel R Ares; Luis Botana
Comparative cytotoxicity of gambierol versus other marine neurotoxins.
Chemical research in toxicology 2011;24(6):835-42.
2011: Hester J van den Top; Hans P van Egmond; Natalia Vilariño; Luis Botana; Christopher T Elliott; Simon A Haughey; Katrina Campbell
Surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins: a pilot interlaboratory study.
Analytical chemistry 2011;83(11):4206-13.
2011: Sheila Pérez; Carmen Vale; Eva Alonso; Carmen Alfonso; Paula Rodríguez; Paz Otero; Amparo Alfonso; Paulo Vale; Masahiro Hirama; Mercedes R Vieytes; Luis Botana
A comparative study of the effect of ciguatoxins on voltage-dependent Na+ and K+ channels in cerebellar neurons.
Chemical research in toxicology 2011;24(4):587-96.
2011: M Carmen Louzao; Isabel R Ares; Eva Cagide; Begoña Espiña; Natalia Vilariño; Amparo Alfonso; Mercedes R Vieytes; Luis Botana
Palytoxins and cytoskeleton: An overview.
Toxicon : official journal of the International Society on Toxinology 2011;57(3):460-9.
2011: Eva Alonso; Lydia Giménez-Llort; Frank M LaFerla; Carmen Vale; Mercedes R Vieytes; Luis Botana
The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;27(6):783-94.
2011: Begoña Espiña; Eva S Fonfria; M Carmen Louzao; Mercedes R Vieytes; Natalia Vilariño; Isabel R Ares; Luis Botana
Disruption of the actin cytoskeleton induces fluorescent glucose accumulation on the rat hepatocytes Clone 9.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;27(6):653-60.
2010: Carolina B Wandscheer; Natalia Vilariño; Begoña Espiña; M Carmen Louzao; Luis Botana
Human muscarinic acetylcholine receptors are a target of the marine toxin 13-desmethyl C spirolide.
Chemical research in toxicology 2010;23(11):1753-61.
2010: Sébastien Schlumberger; Gilles Ouanounou; Emmanuelle Girard; Makoto Sasaki; Haruhiko Fuwa; M Carmen Louzao; Luis Botana; Evelyne Benoit; Jordi Molgó
The marine polyether gambierol enhances muscle contraction and blocks a transient K(+) current in skeletal muscle cells.
Toxicon : official journal of the International Society on Toxinology 2010;56(5):785-91.
2010: M Carmen Louzao; Begoña Espiña; Eva Cagide; Isabel R Ares; Amparo Alfonso; Mercedes R Vieytes; Luis Botana
Cytotoxic effect of palytoxin on mussel.
Toxicon : official journal of the International Society on Toxinology 2010;56(5):842-7.
2010: P Rodríguez; Amparo Alfonso; A M Botana; Mercedes R Vieytes; Luis Botana
Comparative analysis of pre- and post-column oxidation methods for detection of paralytic shellfish toxins.
Toxicon : official journal of the International Society on Toxinology 2010;56(3):448-57.
2010: Eva S Fonfría; Natalia Vilariño; Jordi Molgó; Rómulo Aráoz; Paz Otero; Begoña Espiña; M Carmen Louzao; Mercedes Alvarez; Luis Botana
Detection of 13,19-didesmethyl C spirolide by fluorescence polarization using Torpedo electrocyte membranes.
Analytical biochemistry 2010;403(1-2):102-7.
2010: Paz Otero; Amparo Alfonso; Carmen Alfonso; Mercedes R Vieytes; M Carmen Louzao; Ana M Botana; Luis Botana
New protocol to obtain spirolides from Alexandrium ostenfeldii cultures with high recovery and purity.
Biomedical chromatography : BMC 2010;24(8):878-86.
2010: Paz Otero; Sheila Pérez; Amparo Alfonso; Carmen Vale; Paula Rodríguez; Neide N Gouveia; Nuno Gouveia; João Delgado; Paulo Vale; Masahiro Hirama; Yuuki Ishihara; Jordi Molgó; Luis Botana
First toxin profile of ciguateric fish in Madeira Arquipelago (Europe).
Analytical chemistry 2010;82(14):6032-9.
2010: Natalia Vilariño; M Carmen Louzao; Mercedes R Vieytes; Luis Botana
Biological methods for marine toxin detection.
Analytical and bioanalytical chemistry 2010;397(5):1673-81.
2010: Rómulo Aráoz; Natalia Vilariño; Luis Botana; Jordi Molgó
Ligand-binding assays for cyanobacterial neurotoxins targeting cholinergic receptors.
Analytical and bioanalytical chemistry 2010;397(5):1695-704.
2010: E Alonso; C Vale; M Sasaki; H Fuwa; Y Konno; S Perez; M R Vieytes; Luis Botana
Calcium oscillations induced by gambierol in cerebellar granule cells.
Journal of cellular biochemistry 2010;110(2):497-508.
2010: Carmen Vale; Eva Alonso; Juan A Rubiolo; Mercedes R Vieytes; Frank M LaFerla; Lydia Giménez-Llort; Luis Botana
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Cellular and molecular neurobiology 2010;30(4):577-90.
2010: Katrina Campbell; Simon A Haughey; Hester van den Top; Hans van Egmond; Natalia Vilariño; Luis Botana; Christopher T Elliott
Single laboratory validation of a surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins.
Analytical chemistry 2010;82(7):2977-88.
2010: Begoña Espiña; M Carmen Louzao; Isabel R Ares; Eva S Fonfría; Natalia Vilariño; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Impact of the pectenotoxin C-43 oxidation degree on its cytotoxic effect on rat hepatocytes.
Chemical research in toxicology 2010;23(3):504-15.
2010: Paz Otero; Amparo Alfonso; Mercedes R Vieytes; Ana G Cabado; Juan M Vieites; Luis Botana
Effects of environmental regimens on the toxin profile of Alexandrium ostenfeldii.
Environmental toxicology and chemistry / SETAC 2010;29(2):301-10.
2010: Antonio Reboreda; Jorge Lago; María-José Chapela; Juan M Vieites; Luis Botana; Amparo Alfonso; Ana G Cabado
Decrease of marine toxin content in bivalves by industrial processes.
Toxicon : official journal of the International Society on Toxinology 2010;55(2-3):235-43.
2010: Eva S Fonfría; Natalia Vilariño; Begoña Espiña; M Carmen Louzao; Mercedes Alvarez; Jordi Molgó; Rómulo Aráoz; Luis Botana
Feasibility of gymnodimine and 13-desmethyl C spirolide detection by fluorescence polarization using a receptor-based assay in shellfish matrixes.
Analytica chimica acta 2010;657(1):75-82.
2010: Begoña Espiña; M Carmen Louzao; Eva Cagide; Amparo Alfonso; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes.
British journal of pharmacology 2010;159(2):337-44.
2010: Carmen Vale; KC Nicolaou; Michael O Frederick; Mercedes R Vieytes; Luis Botana
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.
Toxicological sciences : an official journal of the Society of Toxicology 2010;113(1):158-68.
2009: Natalia Vilariño; Eva S Fonfría; Jordi Molgó; Rómulo Aráoz; Luis Botana
Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization.
Analytical chemistry 2009;81(7):2708-14.
2009: Isabel R Ares; Eva Cagide; M Carmen Louzao; Begoña Espiña; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Ostreocin-D impact on globular actin of intact cells.
Chemical research in toxicology 2009;22(2):374-81.
2009: Begoña Espiña; Eva Cagide; M Carmen Louzao; Maria M Fernandez; Mercedes R Vieytes; Panagiota Katikou; Adriano Villar; David Jaen; Luz Maman; Luis Botana
Specific and dynamic detection of palytoxins by in vitro microplate assay with human neuroblastoma cells.
Bioscience reports 2009;29(1):13-23.
2009: Natalia Vilariño; Eva S Fonfría; M Carmen Louzao; Luis Botana
Use of biosensors as alternatives to current regulatory methods for marine biotoxins.
Sensors (Basel, Switzerland) 2009;9(11):9414-43.
2009: Eva Cagide; M Carmen Louzao; Begoña Espiña; Mercedes R Vieytes; David Jaen; Luz Maman; Takeshi Yasumoto; Luis Botana
Production of functionally active palytoxin-like compounds by Mediterranean Ostreopsis cf. siamensis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009;23(4-6):431-40.
2008: Carmen Alfonso; Nils Rehmann; Philipp Hess; Amparo Alfonso; Carolina B Wandscheer; María Abuín; Carmen Vale; Paz Otero; Mercedes R Vieytes; Luis Botana
Evaluation of various pH and temperature conditions on the stability of azaspiracids and their importance in preparative isolation and toxicological studies.
Analytical chemistry 2008;80(24):9672-80.
2008: Luis Botana
Marine toxins and the cytoskeleton.
The FEBS journal 2008;275(24):6059.
2008: Carmen Vale; Luis Botana
Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins.
The FEBS journal 2008;275(24):6060-6.
2008: B Espiña; M Carmen Louzao; Isabel R Ares; Eva Cagide; Mercedes R Vieytes; F V Vega; J A Rubiolo; C O Miles; T Suzuki; Takeshi Yasumoto; Luis Botana
Cytoskeletal toxicity of pectenotoxins in hepatic cells.
British journal of pharmacology 2008;155(6):934-44.
2008: Carmen Vale; Carolina Wandscheer; KC Nicolaou; Michael O Frederick; Carmen Alfonso; Mercedes R Vieytes; Luis Botana
Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: involvement of the c-Jun N-terminal kinase.
Journal of neuroscience research 2008;86(13):2952-62.
2008: Natalia Vilariño; KC Nicolaou; Michael O Frederick; Eva Cagide; Carmen Alfonso; Eva Alonso; Mercedes R Vieytes; Luis Botana
Azaspiracid substituent at C1 is relevant to in vitro toxicity.
Chemical research in toxicology 2008;21(9):1823-31.
2008: Eva Alonso; Amparo Alfonso; Kristin Löber; Luis Botana
The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect.
Journal of cellular biochemistry 2008;105(1):255-61.
2008: M Carmen Louzao; Begoña Espiña; Mercedes R Vieytes; Felix V Vega; Juan A Rubiolo; Otto Baba; Tatsuo Terashima; Luis Botana
"Fluorescent glycogen" formation with sensibility for in vivo and in vitro detection.
Glycoconjugate journal 2008;25(6):503-10.
2008: Paula Rodriguez; Amparo Alfonso; Carmen Vale; Carmen Alfonso; Paulo Vale; Antonio Tellez; Luis Botana
First toxicity report of tetrodotoxin and 5,6,11-trideoxyTTX in the trumpet shell Charonia lampas lampas in Europe.
Analytical chemistry 2008;80(14):5622-9.
2008: Eva S Fonfría; Natalia Vilariño; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Feasibility of using a surface plasmon resonance-based biosensor to detect and quantify yessotoxin.
Analytica chimica acta 2008;617(1-2):167-70.
2008: Carmen Alfonso; Amparo Alfonso; Paz Otero; Paula Rodríguez; Mercedes R Vieytes; Chris Elliot; Cowan Higgins; Luis Botana
Purification of five azaspiracids from mussel samples contaminated with DSP toxins and azaspiracids.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;865(1-2):133-40.
2008: A Villar González; ML Rodríguez-Velasco; Begoña Ben-Gigirey; T Yasumoto; Luis Botana
Assessment of the hydrolysis process for the determination of okadaic acid-group toxin ester: presence of okadaic acid 7-O-acyl-ester derivates in Spanish shellfish.
Toxicon : official journal of the International Society on Toxinology 2008;51(5):765-73.
2008: Carmen Vale; Amparo Alfonso; Mercedes R Vieytes; Xosé Manuel Romarís; Fabiola Arévalo; Ana M Botana; Luis Botana
In vitro and in vivo evaluation of paralytic shellfish poisoning toxin potency and the influence of the pH of extraction.
Analytical chemistry 2008;80(5):1770-6.
2008: Natalia Vilariño; Isabel R Ares; Eva Cagide; M Carmen Louzao; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Induction of actin cytoskeleton rearrangement by methyl okadaate--comparison with okadaic acid.
The FEBS journal 2008;275(5):926-34.
2008: Kristin Löber; Amparo Alfonso; Luis Escribano; Luis Botana
Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation.
Journal of cellular biochemistry 2008;103(4):1076-88.
2008: Kristin Löber; Amparo Alfonso; Luis Escribano; Luis Botana
STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816.
Journal of cellular biochemistry 2008;103(3):865-76.
2007: Esther Melgarejo; Miguel Angel Medina; Francisca Sánchez-Jiménez; Luis Botana; M Domínguez; L Escribano; A Orfao; José Luis Urdiales
(-)-Epigallocatechin-3-gallate interferes with mast cell adhesiveness, migration and its potential to recruit monocytes.
Cellular and molecular life sciences : CMLS 2007;64(19-20):2690-701.
2007: C Vale-Gonzalez; María-José Pazos; Amparo Alfonso; Mercedes R Vieytes; Luis Botana
Study of the neuronal effects of ouabain and palytoxin and their binding to Na,K-ATPases using an optical biosensor.
Toxicon : official journal of the International Society on Toxinology 2007;50(4):541-52.
2007: Nuria M Llamas; Linda Stewart; Terence L Fodey; H Cowan Higgins; María Luisa R Velasco; Luis Botana; Christopher T Elliott
Development of a novel immunobiosensor method for the rapid detection of okadaic acid contamination in shellfish extracts.
Analytical and bioanalytical chemistry 2007;389(2):581-7.
2007: Carmen Vale; Belén Gómez-Limia; Mercedes R Vieytes; Luis Botana
Mitogen-activated protein kinases regulate palytoxin-induced calcium influx and cytotoxicity in cultured neurons.
British journal of pharmacology 2007;152(2):256-66.
2007: Eva S Fonfría; Natalia Vilariño; Katrina Campbell; Chris Elliott; Simon A Haughey; Begoña Ben-Gigirey; Juan M Vieites; Kentaro Kawatsu; Luis Botana
Paralytic shellfish poisoning detection by surface plasmon resonance-based biosensors in shellfish matrixes.
Analytical chemistry 2007;79(16):6303-11.
2007: Natalia Vilariño; KC Nicolaou; Michael O Frederick; Mercedes R Vieytes; Luis Botana
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells.
Biochemical pharmacology 2007;74(2):327-35.
2007: A Villar González; ML Rodríguez-Velasco; Begoña Ben-Gigirey; Luis Botana
Lipophilic toxin profile in Galicia (Spain): 2005 toxic episode.
Toxicon : official journal of the International Society on Toxinology 2007;49(8):1129-34.
2007: C Alfonso; Amparo Alfonso; María-José Pazos; Mercedes R Vieytes; Takeshi Yasumoto; Anna Milandri; Roberto Poletti; Luis Botana
Extraction and cleaning methods to detect yessotoxins in contaminated mussels.
Analytical biochemistry 2007;363(2):228-38.
2007: M Carmen Louzao; Isabel R Ares; Mercedes R Vieytes; Iago Valverde; Juan M Vieites; Takeshi Yasumoto; Luis Botana
The cytoskeleton, a structure that is susceptible to the toxic mechanism activated by palytoxins in human excitable cells.
The FEBS journal 2007;274(8):1991-2004.
2007: Begoña Ben-Gigirey; ML Rodríguez-Velasco; A Villar González; Luis Botana
Influence of the sample toxic profile on the suitability of a high performance liquid chromatography method for official paralytic shellfish toxins control.
Journal of chromatography. A 2007;1140(1-2):78-87.
2007: Carmen Vale; KC Nicolaou; Michael O Frederick; Belén Gómez-Limia; Amparo Alfonso; Mercedes R Vieytes; Luis Botana
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study.
Journal of medicinal chemistry 2007;50(2):356-63.
2007: Carmen Vale; Belén Gómez-Limia; KC Nicolaou; Michael O Frederick; Mercedes R Vieytes; Luis Botana
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(6):957-66.
2007: Isabel R Ares; M Carmen Louzao; Begoña Espiña; Mercedes R Vieytes; Christopher O Miles; Takeshi Yasumoto; Luis Botana
Lactone ring of pectenotoxins: a key factor for their activity on cytoskeletal dynamics.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;19(5-6):283-92.
2007: Eva Cagide; M Carmen Louzao; Isabel R Ares; Mercedes R Vieytes; Mari Yotsu-Yamashita; Leo A Paquette; Takeshi Yasumoto; Luis Botana
Effects of a synthetic analog of polycavernoside A on human neuroblastoma cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;19(1-4):185-94.
2007: Carmen Vale-González; Belén Gómez-Limia; Mercedes R Vieytes; Luis Botana
Effects of the marine phycotoxin palytoxin on neuronal pH in primary cultures of cerebellar granule cells.
Journal of neuroscience research 2007;85(1):90-8.
2006: A Villar González; ML Rodríguez-Velasco; Begoña Ben-Gigirey; Luis Botana
First evidence of spirolides in Spanish shellfish.
Toxicon : official journal of the International Society on Toxinology 2006;48(8):1068-74.
2006: Octavio Pernas-Sueiras; Amparo Alfonso; Mercedes R Vieytes; Luis Botana
PKC and cAMP positively modulate alkaline-induced exocytosis in the human mast cell line HMC-1.
Journal of cellular biochemistry 2006;99(6):1651-63.
2006: Octavio Pernas-Sueiras; Amparo Alfonso; Mercedes R Vieytes; Alberto Orfao; Luis Escribano; Sánchez-Jiménez Francisca; Luis Botana
Calcium-pH crosstalks in the human mast cell line HMC-1: intracellular alkalinization activates calcium extrusion through the plasma membrane Ca2+-ATPase.
Journal of cellular biochemistry 2006;99(5):1397-408.
2006: Natalia Vilariño; KC Nicolaou; Michael O Frederick; Eva Cagide; Isabel R Ares; M Carmen Louzao; Mercedes R Vieytes; Luis Botana
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies.
Chemical research in toxicology 2006;19(11):1459-66.
2006: Andres C Garcia-Montero; Maria Jara-Acevedo; Cristina Teodosio; Maria Luz Sanchez; Rosa Nunez; Aranzazu Prados; Isabel Aldanondo; Laura Sanchez; Mercedes Dominguez; Luis Botana; Francisca Sanchez-Jimenez; Karl Sotlar; Julia Almeida; Luis Escribano; Alberto Orfao
KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients.
Blood 2006;108(7):2366-72.
2006: Amparo Alfonso; Mercedes R Vieytes; Katsuya Ofuji; Masayuki Satake; KC Nicolaou; Michael O Frederick; Luis Botana
Azaspiracids modulate intracellular pH levels in human lymphocytes.
Biochemical and biophysical research communications 2006;346(3):1091-9.
2006: Carmen Vale-González; Amparo Alfonso; Cristina Suñol; Mercedes R Vieytes; Luis Botana
Role of the plasma membrane calcium adenosine triphosphatase on domoate-induced intracellular acidification in primary cultures of cerebelar granule cells.
Journal of neuroscience research 2006;84(2):326-37.
2006: María-José Pazos; Amparo Alfonso; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Study of the interaction between different phosphodiesterases and yessotoxin using a resonant mirror biosensor.
Chemical research in toxicology 2006;19(6):794-800.
2006: M Carmen Louzao; Mercedes R Vieytes; Takeshi Yasumoto; Mari Yotsu-Yamashita; Luis Botana
Changes in membrane potential: an early signal triggered by neurologically active phycotoxins.
Chemical research in toxicology 2006;19(6):788-93.
2006: Carmen Vale; Amparo Alfonso; Cristina Suñol; Mercedes R Vieytes; Luis Botana
Modulation of calcium entry and glutamate release in cultured cerebellar granule cells by palytoxin.
Journal of neuroscience research 2006;83(8):1393-406.
2006: Philipp Hess; Barbara Grune; David B Anderson; Tore Aune; Luis Botana; Paolo Caricato; Hans P van Egmond; Marlies Halder; Sherwood Hall; James F Lawrence; Colin Moffat; Roberto Poletti; JON RICHMOND; Gian Paolo Rossini; Catherine Seamer; Jorge Serratosa Vilageliu
Three Rs Approaches in Marine Biotoxin Testing. The Report and Recommendations of a joint ECVAM/DG SANCO Workshop (ECVAM Workshop 54).
Alternatives to laboratory animals : ATLA 2006;34(2):193-224.
2006: M Carmen Louzao; Eva Cagide; Mercedes R Vieytes; Makoto Sasaki; Haruhiko Fuwa; Takeshi Yasumoto; Luis Botana
The sodium channel of human excitable cells is a target for gambierol.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006;17(5-6):257-68.
2005: Isabel R Ares; M Carmen Louzao; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins.
The Journal of experimental biology 2005;208(Pt 22):4345-54.
2005: Carmen Alfonso; Amparo Alfonso; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Quantification of yessotoxin using the fluorescence polarization technique and study of the adequate extraction procedure.
Analytical biochemistry 2005;344(2):266-74.
2005: Octavio Pernas-Sueiras; Amparo Alfonso; Mercedes R Vieytes; Luis Botana
Mast cell exocytosis can be triggered by ammonium chloride with just a cytosolic alkalinization and no calcium increase.
Journal of cellular physiology 2005;204(3):775-84.
2005: María-José Pazos; Amparo Alfonso; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Kinetic analysis of the interaction between yessotoxin and analogues and immobilized phosphodiesterases using a resonant mirror optical biosensor.
Chemical research in toxicology 2005;18(7):1155-60.
2005: Amparo Alfonso; Yolanda Román; Mercedes R Vieytes; Katsuya Ofuji; Masayuki Satake; Takeshi Yasumoto; Luis Botana
Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes.
Biochemical pharmacology 2005;69(11):1627-36.
2005: M Carmen Louzao; Mercedes R Vieytes; Luis Botana
Effect of okadaic acid on glucose regulation.
Mini reviews in medicinal chemistry 2005;5(2):207-15.
2005: Amparo Alfonso; Mercedes R Vieytes; Luis Botana
Calcium-pH crosstalks in rat mast cells: modulation by transduction signals show non-essential role for calcium in alkaline-induced exocytosis.
Biochemical pharmacology 2005;69(2):319-27.
2004: María-José Pazos; Amparo Alfonso; Mercedes R Vieytes; Takeshi Yasumoto; Juan M Vieites; Luis Botana
Resonant mirror biosensor detection method based on yessotoxin-phosphodiesterase interactions.
Analytical biochemistry 2004;335(1):112-8.
2004: Yolanda Román; Amparo Alfonso; Mercedes R Vieytes; Katsuya Ofuji; Masayuki Satake; Takeshi Yasumoto; Luis Botana
Effects of Azaspiracids 2 and 3 on intracellular cAMP, [Ca2+], and pH.
Chemical research in toxicology 2004;17(10):1338-49.
2004: M Carmen Louzao; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Detection of sodium channel activators by a rapid fluorimetric microplate assay.
Chemical research in toxicology 2004;17(4):572-8.
2004: Amparo Alfonso; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
A rapid microplate fluorescence method to detect yessotoxins based on their capacity to activate phosphodiesterases.
Analytical biochemistry 2004;326(1):93-9.
2004: Ana G Cabado; Francisco Leira; Mercedes R Vieytes; Juan M Vieites; Luis Botana
Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells.
Archives of toxicology 2004;78(2):74-85.
2003: Francisco Leira; C Alvarez; Ana G Cabado; Juan M Vieites; Mercedes R Vieytes; Luis Botana
Development of a F actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins.
Analytical biochemistry 2003;317(2):129-35.
2003: M Carmen Louzao; Mercedes Rodriguez Vieytes; Ana Garcia Cabado; Juan Manuel Vieites Baptista De Sousa; Luis Botana
A fluorimetric microplate assay for detection and quantitation of toxins causing paralytic shellfish poisoning.
Chemical research in toxicology 2003;16(4):433-8.
2003: Amparo Alfonso; Laura A de la Rosa; Mercedes R Vieytes; Luis Botana
Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes.
Biochemical pharmacology 2003;65(3):465-78.
2003: Natalia Vilariño; Laura A de la Rosa; Mercedes R Vieytes; Luis Botana
The Cl-HCO3- exchanger slows the recovery of acute pHi changes in rat mast cells.
Biochemical pharmacology 2003;65(3):389-96.
2003: Amparo Alfonso; Laura A de la Rosa; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes.
Biochemical pharmacology 2003;65(2):193-208.
2003: M Carmen Louzao; Mercedes R Vieytes; Olga I Fontal; Luis Botana
Glucose uptake in enterocytes: a test for molecular targets of okadaic acid.
Journal of receptor and signal transduction research 2003;23(2-3):211-24.
2002: Yolanda Román; Amparo Alfonso; M Carmen Louzao; Laura A de la Rosa; Francisco Leira; Juan M Vieites; Mercedes R Vieytes; Katsuya Ofuji; Masayuki Satake; Takeshi Yasumoto; Luis Botana
Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets.
Cellular signalling 2002;14(8):703-16.
2002: Francisco Leira; Ana G Cabado; Mercedes R Vieytes; Yolanda Roman; Amparo Alfonso; Luis Botana; Takeshi Yasumoto; Claudia Malaguti; Gian Paolo Rossini
Characterization of F-actin depolymerization as a major toxic event induced by pectenotoxin-6 in neuroblastoma cells.
Biochemical pharmacology 2002;63(11):1979-88.
2002: Francisco Leira; M Carmen Louzao; Juan M Vieites; Luis Botana; Mercedes R Vieytes
Fluorescent microplate cell assay to measure uptake and metabolism of glucose in normal human lung fibroblasts.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(3):267-73.
2002: Francisco Leira; C Alvarez; Juan M Vieites; Mercedes R Vieytes; Luis Botana
Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(1):23-31.
2002: José C González; Olga I Fontal; Mercedes R Vieytes; Juan M Vieites; Luis Botana
Basis for a new procedure to eliminate diarrheic shellfish toxins from a contaminated matrix.
Journal of agricultural and food chemistry 2002;50(2):400-5.
2001: Yolanda Román; Amparo Alfonso; M Carmen Louzao; Mercedes R Vieytes; Luis Botana
Confocal microscopy study of the different patterns of 2-NBDG uptake in rabbit enterocytes in the apical and basal zone.
Pflügers Archiv : European journal of physiology 2001;443(2):234-9.
2001: Amparo Alfonso; MA Botana; Mercedes R Vieytes; Luis Botana
Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases.
Cellular signalling 2001;13(11):819-26.
2001: Laura A de la Rosa; Amparo Alfonso; Natalia Vilariño; Mercedes R Vieytes; Takeshi Yasumoto; Luis Botana
Maitotoxin-induced calcium entry in human lymphocytes: modulation by yessotoxin, Ca(2+) channel blockers and kinases.
Cellular signalling 2001;13(10):711-6.
2001: Francisco Leira; C Alvarez; Juan M Vieites; Mercedes R Vieytes; Luis Botana
Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(4-5):277-82.
2001: J Lago; Amparo Alfonso; Mercedes R Vieytes; Luis Botana
Ouabain-induced enhancement of rat mast cells response. Modulation by protein phosphorylation and intracellular pH.
Cellular signalling 2001;13(7):515-24.
2001: Laura A de la Rosa; Natalia Vilariño; Mercedes R Vieytes; Luis Botana
Modulation of thapsigargin-induced calcium mobilisation by cyclic AMP-elevating agents in human lymphocytes is insensitive to the action of the protein kinase A inhibitor H-89.
Cellular signalling 2001;13(6):441-9.
2001: Francisco Leira; Juan M Vieites; Mercedes R Vieytes; Luis Botana
Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(3):199-208.
2001: José M Quintela; Carlos Peinador; M J Moreira; Amparo Alfonso; Luis Botana; Ricardo Riguera
Pyrazolopyrimidines: synthesis, effect on histamine release from rat peritoneal mast cells and cytotoxic activity.
European journal of medicinal chemistry 2001;36(4):321-32.
2001: Laura A de la Rosa; Amparo Alfonso; Natalia Vilariño; Mercedes R Vieytes; Luis Botana
Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin.
Biochemical pharmacology 2001;61(7):827-33.
2001: Natalia Vilariño; Laura A de la Rosa; Mercedes R Vieytes; Luis Botana
HCO(3)(-) ions modify the role of PKC isoforms in the modulation of rat mast cell functions.
Cellular signalling 2001;13(3):177-90.
2001: José C González; Mercedes R Vieytes; A M Botana; Juan M Vieites; Luis Botana
Modified mass action law-based model to correlate the solubility of solids and liquids in entrained supercritical carbon dioxide.
Journal of chromatography. A 2001;910(1):119-25.
2001: M Carmen Louzao; Mercedes R Vieytes; JM Baptista de Sousa; Francisco Leira; Luis Botana
A fluorimetric method based on changes in membrane potential for screening paralytic shellfish toxins in mussels.
Analytical biochemistry 2001;289(2):246-50.
2001: Natalia Vilariño; Laura A de la Rosa; Mercedes R Vieytes; Luis Botana
HCO3(-) ions increase mast cell sensitivity to thapsigargin-induced Ca(2+) entry.
Biochemical and biophysical research communications 2001;280(2):518-21.
2000: Francisco Leira; Juan M Vieites; Mercedes R Vieytes; Luis Botana
Characterization of 9H-(1,3-dichlor-9, 9-dimethylacridin-2-ona-7-yl)-phosphate (DDAO) as substrate of PP-2A in a fluorimetric microplate assay for diarrhetic shellfish toxins (DSP).
Toxicon : official journal of the International Society on Toxinology 2000;38(12):1833-44.
2000: Ana G Cabado; Amparo Alfonso; Mercedes R Vieytes; Luis Botana
Hypertonicity-induced intracellular pH changes in rat mast cells.
Life sciences 2000;67(16):1969-82.
2000: Ana G Cabado; Amparo Alfonso; Mercedes R Vieytes; M González; MA Botana; Luis Botana
Crosstalk between cytosolic pH and intracellular calcium in human lymphocytes: effect of 4-aminopyridin, ammoniun chloride and ionomycin.
Cellular signalling 2000;12(8):573-81.
2000: Amparo Alfonso; Ana G Cabado; Mercedes R Vieytes; Luis Botana
Calcium-pH crosstalks in rat mast cells: cytosolic alkalinization, but not intracellular calcium release, is a sufficient signal for degranulation.
British journal of pharmacology 2000;130(8):1809-16.
2000: Amparo Alfonso; Ana G Cabado; Mercedes R Vieytes; Luis Botana
Functional compartments in rat mast cells for cAMP and calcium on histamine release.
Cellular signalling 2000;12(5):343-50.
2000: José C González; Francisco Leira; Mercedes R Vieytes; Juan M Vieites; A M Botana; Luis Botana
Development and validation of a high-performance liquid chromatographic method using fluorimetric detection for the determination of the diarrhetic shellfish poisoning toxin okadaic acid without chlorinated solvents.
Journal of chromatography. A 2000;876(1-2):117-25.
1999: Natalia Vilariño; Mercedes R Vieytes; Juan M Vieites; Luis Botana
Modulatory effect of HCO3- on rat mast cell exocytosis: cross-talks between bicarbonate and calcium.
Biochemical and biophysical research communications 1999;260(1):71-9.
1999: Laura A de la Rosa; Ana G Cabado; MA Botana; Mercedes R Vieytes; J I Vidal; Luis Botana
Evidence for an electrogenic, negatively protein-kinase-A-modulated, Na+-dependent HCO3- transporter in human lymphocytes.
Pflügers Archiv : European journal of physiology 1999;437(6):935-43.
1999: Juan M Vieites; Luis Botana; Mercedes R Vieytes; Francisco Leira
Canning process that diminishes paralytic shellfish poison in naturally contaminated mussels (Mytilus galloprovincialis).
Journal of food protection 1999;62(5):515-9.
1999: Olga I Fontal; Mercedes R Vieytes; JM Baptista de Sousa; M Carmen Louzao; Luis Botana
A fluorescent microplate assay for microcystin-LR.
Analytical biochemistry 1999;269(2):289-96.
1999: Amparo Alfonso; J Lago; MA Botana; Mercedes R Vieytes; Luis Botana
Characterization of the Na+/Ca2+ exchanger on rat mast cells. Evidence for a functional role on the regulation of the cellular response.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1999;9(2):53-71.
1999: Ana G Cabado; Sanda Despa; MA Botana; Mercedes R Vieytes; M González; Luis Botana
Membrane potential changes associated with calcium signals in human lymphocytes and rat mast cells.
Life sciences 1999;64(8):681-96.
1998: Natalia Vilariño; Mercedes R Vieytes; Juan M Vieites; Luis Botana
Role of HCO3- ions in cytosolic pH regulation in rat mast cells: evidence for a new Na+-independent, HCO3--dependent alkalinizing mechanism.
Biochemical and biophysical research communications 1998;253(2):320-4.
1998: José M Quintela; Carlos Peinador; C Veiga; Liliana González; Luis Botana; Amparo Alfonso; Ricardo Riguera
Synthesis and antiallergic activity of pyridothienopyrimidines.
Bioorganic & medicinal chemistry 1998;6(10):1911-25.
1998: José C González; Mercedes R Vieytes; Juan M Vieites; Luis Botana
Improvement on sample clean-up for high-performance liquid chromatographic-fluorimetric determination of diarrhetic shellfish toxins using 1-bromoacetylpyrene.
Journal of chromatography. A 1998;793(1):63-70.
1998: Amparo Alfonso; MA Botana; Mercedes R Vieytes; Luis Botana
Sodium, PMA and calcium play an important role on intracellular pH modulation in rat mast cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1998;8(6):314-27.
1998: Ana G Cabado; Mercedes R Vieytes; Luis Botana
Inhibition of Na+/K+ ATPase under hypertonic conditions in rat mast cells.
Life sciences 1998;63(14):1227-37.
1997: José M Quintela; Carlos Peinador; Luis Botana; M Estévez; Ricardo Riguera
Synthesis and antihistaminic activity of 2-guanadino-3-cyanopyridines and pyrido[2,3-d]-pyrimidines.
Bioorganic & medicinal chemistry 1997;5(8):1543-53.
1997: Mercedes R Vieytes; Olga I Fontal; Francisco Leira; JM Baptista de Sousa; Luis Botana
A fluorescent microplate assay for diarrheic shellfish toxins.
Analytical biochemistry 1997;248(2):258-64.
1997: M D Estévez; Mercedes R Vieytes; M Carmen Louzao; Amparo Alfonso; Natalia Vilariño; Luis Botana
The antineoplastic drug vinorelbine activates non-immunological histamine release from rat mast cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(4):119-24.
1996: M D Estévez; Mercedes R Vieytes; Luis Botana
Mitoxantrone induces nonimmunological histamine release from rat mast cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1996;45(3):113-7.
1996: Juan M Vieites; F Leira; Luis Botana; Mercedes R Vieytes
Determination of DSP toxins: comparative study of HPLC and bioassay to reduce the observation time of the mouse bioassay.
Archives of toxicology 1996;70(7):440-3.
1995: Amparo Alfonso; M Estévez; M Carmen Louzao; Mercedes R Vieytes; Luis Botana
Determination of phosphodiesterase activity in rat mast cells using the fluorescent cAMP analogue anthraniloyl cAMP.
Cellular signalling 1995;7(5):513-8.
1995: M D Estévez; Amparo Alfonso; Mercedes R Vieytes; M Carmen Louzao; Luis Botana
Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1995;44(2):87-91.
1994: Amparo Alfonso; M Carmen Louzao; Mercedes R Vieytes; Luis Botana
Comparative study of the stability of saxitoxin and neosaxitoxin in acidic solutions and lyophilized samples.
Toxicon : official journal of the International Society on Toxinology 1994;32(12):1593-8.
1994: M D Estévez; Mercedes R Vieytes; Luis Botana
Study of the activation mechanism of adriamycin on rat mast cells.
Agents and actions 1994;42(3-4):86-91.
1994: M Carmen Louzao; Amparo Alfonso; A M Botana; X Goenaga; Ana G Cabado; Mercedes R Vieytes; Luis Botana
Effect of lyophilization on the stability of gonyautoxins obtained from contaminated mussels.
Toxicon : official journal of the International Society on Toxinology 1994;32(7):807-17.
1994: M Columbo; Luis Botana; EDWARD HOROWITZ; Lawrence M Lichtenstein; Donald MacGlashan
Studies of the intracellular Ca2+ levels in human adult skin mast cells activated by the ligand for the human c-kit receptor and anti-IgE.
Biochemical pharmacology 1994;47(12):2137-45.
1994: Luis Botana; Donald MacGlashan
Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils.
Journal of leukocyte biology 1994;55(6):798-804.
1994: Amparo Alfonso; MA Botana; Mercedes R Vieytes; M Carmen Louzao; Luis Botana
Effect of signal transduction pathways on the action of thapsigargin on rat mast cells. Crosstalks between cellular signalling and cytosolic pH.
Biochemical pharmacology 1994;47(10):1813-20.
1994: Amparo Alfonso; MA Botana; Mercedes R Vieytes; Luis Botana
Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways.
European journal of pharmacology 1994;267(3):289-96.
1994: M D Estévez; Mercedes R Vieytes; M Carmen Louzao; Luis Botana
Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells.
Biochemical pharmacology 1994;47(3):591-3.
1994: Ana G Cabado; Mercedes R Vieytes; Luis Botana
Effect of ion composition on the changes in membrane potential induced with several stimuli in rat mast cells.
Journal of cellular physiology 1994;158(2):309-16.
1993: Ana G Cabado; Mercedes R Vieytes; Luis Botana
Amiloride-dependent transport is the main mechanism implicated in sodium influx regulation in rat mast cells.
Journal of cellular physiology 1993;156(3):567-70.
1993: Luis Botana; Donald MacGlashan
Effect of okadaic acid on human basophil secretion.
Biochemical pharmacology 1993;45(11):2311-5.
1993: Mercedes R Vieytes; Ana G Cabado; Amparo Alfonso; M Carmen Louzao; A M Botana; Luis Botana
Solid-phase radioreceptor assay for paralytic shellfish toxins.
Analytical biochemistry 1993;211(1):87-93.
1993: Donald MacGlashan; Luis Botana
Biphasic Ca2+ responses in human basophils. Evidence that the initial transient elevation associated with the mobilization of intracellular calcium is an insufficient signal for degranulation.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):980-91.
1993: Ana G Cabado; Mercedes R Vieytes; Luis Botana
Rat pleural and peritoneal mast cells stimulated at different cellular levels: difference in and influence of purification media.
International archives of allergy and immunology 1993;100(3):234-9.
1993: M D Estévez; MA Botana; E Arnáez; Mercedes R Vieytes; Luis Botana
Histamine release on rat pleural and peritoneal mast cells elicited by human GRF(1-29)NH2.
International archives of allergy and immunology 1993;100(1):86-8.
1992: Luis Botana; Amparo Alfonso; MA Botana; Mercedes R Vieytes; M Carmen Louzao; Ana G Cabado
Influence of protein kinase C, cAMP and phosphatase activity on histamine release produced by compound 48/80 and sodium fluoride on rat mast cells.
Agents and actions 1992;37(1-2):1-7.
1992: E Arnaez; Amparo Alfonso; M Estevez; Mercedes R Vieytes; M Carmen Louzao; Luis Botana
Effect of purification, theophylline and sodium fluoride on histamine release produced by antineoplastic drugs on rat mast cells. A distinctive mechanism of action for carboplatin.
Biochemical pharmacology 1992;44(3):533-8.
1992: M Columbo; EDWARD HOROWITZ; Luis Botana; Donald MacGlashan; Bruce S Bochner; S Gillis; K M Zsebo; S J Galli; Lawrence M Lichtenstein
The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):599-608.
1992: Luis Botana; E Arnaez; Mercedes R Vieytes; Amparo Alfonso; M Carmen Louzao
Nonimmunological release of histamine from rat mast cells elicited by antineoplastic agents: effect of drug combinations.
Cancer chemotherapy and pharmacology 1992;30(6):487-90.
1992: Luis Botana; E Arnaez; Mercedes R Vieytes; Amparo Alfonso; M J Bujan; M Carmen Louzao; Ana G Cabado
Non-immunological release of histamine from rat mast cells elicited by antineoplastic agents.
Cancer chemotherapy and pharmacology 1992;29(6):495-8.
1991: Mercedes R Vieytes; M Carmen Louzao; M J Bujan; Amparo Alfonso; Ana G Cabado; L F de la Cruz; Luis Botana
Lack of specific saxitoxin binding to rat mast cells.
Agents and actions 1991;33(1-2):92-3.
1991: Mercedes R Vieytes; Amparo Alfonso; M J Bujan; M Carmen Louzao; A Cavado; L F de la Cruz; Luis Botana
Changes in rat mast cell responses in sodium-free media. Lack of demonstrable sodium channel activity.
Agents and actions 1991;33(1-2):94-6.
1991: Mercedes R Vieytes; L F de la Cruz; Luis Botana
[Inhibition of histamine liberation in mast cells from the lung and the intestine of the dog by isoproterenol].
Revista española de fisiología 1991;47(1):19-24.
1991: Mercedes R Vieytes; M Carmen Louzao; L F de la Cruz; Luis Botana
[Effect of isoproterenol on the liberation of histamine from rat lung mast cells].
Revista española de fisiología 1991;47(1):13-7.
1990: Nélida Eleno; Luis Botana; J Espinosa
K-channel blocking drugs induce histamine release and 45Ca uptake in isolated mast cells.
International archives of allergy and applied immunology 1990;92(2):162-7.
1988: Nélida Eleno; Luis Botana; J Espinosa
Dual effect of dihydropyridines on 45Ca uptake induced by the K+ -channel blocker, 4-aminopyridin on mast cells.
Journal of cellular physiology 1988;137(2):378-83.
1988: N Elenu; Luis Botana; J Espinosa
Veratridine elicits histamine release and promotes calcium uptake in mast cells.
Biochemical pharmacology 1988;37(18):3523-5.
1988: Nélida Eleno; Luis Botana; J Espinosa; M P Fernández-Otero
[Effect of colchicine on histamine secretion and calcium uptake in mast cells].
Revista española de fisiología 1988;44(1):35-40.
1988: Luis Botana; J Espinosa; Nélida Eleno; MA Botana; M P Fernández-Otero
[Effect of NaF and calcium in rats mastocytes in response to norepinephrine].
Revista española de fisiología 1988;44(1):105-6.
1988: Barry H Hirst; Luis Botana; E Arilla; D H Coy
Somatostatin structure-activity studies in the stomach.
Hormone research 1988;29(2-3):79-82.
1987: Nélida Eleno; Luis Botana; C Segura; J Espinosa
Valinomycin, a degranulating agent in rat mast cells which inhibits calcium-uptake.
Agents and actions 1987;22(3-4):189-96.
1987: Nélida Eleno; Francisco Orallo; Luis Botana; J Espinosa; I Cadavid
Hydralazine-relaxing effect on rat aorta is not mediated through changes in ATPase activity.
Archives internationales de pharmacodynamie et de thérapie 1987;285(1):72-9.
1987: Luis Botana
Adrenergic agonists do not compete with the antagonist (-)3-[125I]iodocyanopindolol for binding to rat pleural or peritoneal mast cell adrenergic receptor.
General pharmacology 1987;18(3):263-7.
1987: Luis Botana; J Espinosa; Nélida Eleno
Adrenergic activity on rat pleural and peritoneal mast cells. Loss of beta-receptors during the purification procedure.
General pharmacology 1987;18(2):141-8.
1986: Luis Botana; Nélida Eleno; J Espinosa; M P Fernández-Otero
Effect of calcium on histamine release from pleural and peritoneal mast cells induced by catechol.
Revista española de fisiología 1986;42(4):455-8.
1986: Luis Botana; J Espinosa; M P Fernández-Otero
[Response of pleural and peritoneal mastocyte populations in the rat to agents with different mechanisms of action].
Revista española de fisiología 1986;42(4):449-53.
1986: Luis Botana
[Is the existence of negative interactions between mastocyte populations possible?].
Archivos de farmacología y toxicología 1986;12(2-3):153-6.
1986: Nélida Eleno; Luis Botana; J Espinosa; C Segura; C Taboada; P Fernández-Otero
[Na+ K+ ATPase activity in mast cells from the pleural and peritoneal cavities of the rat].
Revista española de fisiología 1986;42(1):85-9.
1986: Luis Botana; Francisco Orallo; J Espinosa; José María Calleja
In vivo inhibition of polymyxin B-induced hypotension: evidence of beta-adrenergic inhibitory activity on rat mast cells.
General pharmacology 1986;17(5):615-8.
1985: Luis Botana; J Espinosa; Nélida Eleno; C Segura; P Fernández-Otero
Difference in, and influence of the purification medium on, sensitivity and maximum response of peritoneal and pleural mast cells stimulated by certain polyamines.
Agents and actions 1985;16(5):342-5.
1984: J Espinosa; Luis Botana; E Puentes; B J Regueiro
Milk progesterone radioimmunoassay using radioiodinated tracers: a rapid and reliable assay system.
Steroids 1984;44(3):217-28.
1983: J Espinosa; Luis Botana; M P Fernández-Otero
[Secretory activity of mast cells in the presence of cholinergic agonists].
Revista española de fisiología 1983;39(4):441-5.
1983: Luis Botana; J Espinosa; M P Fernández-Otero
[Isolation of mastocytes from rat peritoneal fluid using continuous Ficoll gradients].
Revista española de fisiología 1983;39(4):435-40.