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Zbigniew Darzynkiewicz

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Procedures

Flow Cytometry

Physiology

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DNA Damage

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Jin Akagi; Zbigniew Darzynkiewicz; Jurek Dobrucki; Rachel Errington; Magdalena Kordon; Anna Matuszek; Paul J Smith; Kazuo Takeda; Hong Zhao; Donald Wlodkowic
Real-time cell viability assays using a new anthracycline derivative DRAQ7®.
Hong Zhao; Zbigniew Darzynkiewicz
Biomarkers of cell senescence assessed by imaging cytometry.
Piotr Pozarowski; Elena Holden; Zbigniew Darzynkiewicz
Laser scanning cytometry: principles and applications-an update.

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2013: Jin Akagi; Zbigniew Darzynkiewicz; Jurek Dobrucki; Rachel Errington; Magdalena Kordon; Anna Matuszek; Paul J Smith; Kazuo Takeda; Hong Zhao; Donald Wlodkowic
Real-time cell viability assays using a new anthracycline derivative DRAQ7®.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2013;83(2):227-34.
2013: Hong Zhao; Zbigniew Darzynkiewicz
Biomarkers of cell senescence assessed by imaging cytometry.
Methods in molecular biology (Clifton, N.J.) 2013;965():83-92.
2013: Piotr Pozarowski; Elena Holden; Zbigniew Darzynkiewicz
Laser scanning cytometry: principles and applications-an update.
Methods in molecular biology (Clifton, N.J.) 2013;931():187-212.
2012: Zbigniew Darzynkiewicz
Running m(o)TOR with the brakes on leads to catastrophe at mitosis.
Cell cycle (Georgetown, Tex.) 2012;11(24):4494.
2012: H Dorota Halicka; Tze-Chen Hsieh; Yong-Syu Lee; Jiangwei Li; Joseph M Wu; Hong Zhao; Zbigniew Darzynkiewicz
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
Aging 2012;4(12):952-65.
2012: Donald Wlodkowic; Joanna Skommer; Zbigniew Darzynkiewicz
Cytometry of apoptosis. Historical perspective and new advances.
Experimental oncology 2012;34(3):255-62.
2012: Zbigniew Darzynkiewicz; Jurek Dobrucki; H Dorota Halicka; Paulina Rybak; Hong Zhao; Donald Wlodkowic
DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis.
Critical reviews in clinical laboratory sciences 2012;49(5-6):199-217.
2012: Elise McKenna; Frank Traganos; Hong Zhao; Zbigniew Darzynkiewicz
Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence.
Cell cycle (Georgetown, Tex.) 2012;11(16):3132-40.
2012: Jennifer Chea; Zbigniew Darzynkiewicz; Ernest Y C Lee; Sufang Zhang; Zhongtao Zhang; Hong Zhao; Marietta Y W T Lee
Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.
Cell cycle (Georgetown, Tex.) 2012;11(15):2885-95.
2012: Zbigniew Darzynkiewicz
Cycling into future: mass cytometry for the cell-cycle analysis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012;81(7):546-8.
2012: Nicolas T Kummer; Theodore S Nowicki; Ismael Reyes; Stimson Schantz; Nina Suslina; Ismatun Swati; Raj K Tiwari; Suqing Xie; Jean P Azzi; Zbigniew Darzynkiewicz; Katherine H Gotlinger; Codrin Iacob; Jan Geliebter
Arachidonate 5 lipoxygenase expression in papillary thyroid carcinoma promotes invasion via MMP-9 induction.
Journal of cellular biochemistry 2012;113(6):1998-2008.
2012: H Dorota Halicka; Jiangwei Li; George P Studzinski; Frank Traganos; Hong Zhao; Zbigniew Darzynkiewicz
Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3.
Aging 2012;4(4):270-8.
2012: Zbigniew Darzynkiewicz; Endre A Balazs
Genome integrity, stem cells and hyaluronan.
Aging 2012;4(2):78-88.
2011: Hong Zhao; Jurek Dobrucki; H Dorota Halicka; Paulina Rybak; Frank Traganos; Zbigniew Darzynkiewicz
Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(11):897-902.
2011: Zbigniew Darzynkiewicz
Redundancy in response to DNA damage: the key to protection of genome integrity.
Cell cycle (Georgetown, Tex.) 2011;10(20):3425.
2011: H Dorota Halicka; Marietta Lee; Jiangwei Li; Frank Traganos; Sufang Zhang; Hong Zhao; Zbigniew Darzynkiewicz
Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.
Aging 2011;3(10):1028-38.
2011: Donald Wlodkowic; Zbigniew Darzynkiewicz; Khashayar Khoshmanesh; John C Sharpe; Jonathan M Cooper
Apoptosis goes on a chip: advances in the microfluidic analysis of programmed cell death.
Analytical chemistry 2011;83(17):6439-46.
2011: Reza Soleimani; Zbigniew Darzynkiewicz; Elke Heytens; Kutluk Oktay
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise.
Aging 2011;3(8):782-93.
2011: Hong Zhao; Jiangwei Li; Frank Traganos; H Dorota Halicka; Mirosław Zarebski; Jurek Dobrucki; Zbigniew Darzynkiewicz
Cell fixation in zinc salt solution is compatible with DNA damage response detection by phospho-specific antibodies.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(6):470-6.
2011: Zbigniew Darzynkiewicz; Frank Traganos; Hong Zhao; H Dorota Halicka; Jiangwei Li
Cytometry of DNA replication and RNA synthesis: Historical perspective and recent advances based on "click chemistry".
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(5):328-37.
2011: Zbigniew Darzynkiewicz
Critical aspects in analysis of cellular DNA content.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2011;Chapter 7():Unit 7.2.
2011: Shoujin Hao; Hong Zhao; Zbigniew Darzynkiewicz; Sailaja Battula; Nicholas R Ferreri
Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells.
American journal of physiology. Renal physiology 2011;300(4):F966-75.
2011: Zbigniew Darzynkiewicz
Novel strategies of protecting non-cancer cells during chemotherapy: are they ready for clinical testing?
Oncotarget 2011;2(3):107-8.
2011: Zbigniew Darzynkiewicz; H Dorota Halicka; Joanna Skommer; Frank Traganos; Hong Zhao; Donald Wlodkowic
Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry.
Methods in cell biology 2011;103():115-47.
2011: Donald Wlodkowic; Joanna Skommer; William Telford; Zbigniew Darzynkiewicz
Apoptosis and beyond: cytometry in studies of programmed cell death.
Methods in cell biology 2011;103():55-98.
2011: Donald Wlodkowic; Zbigniew Darzynkiewicz
Rise of the micromachines: microfluidics and the future of cytometry.
Methods in cell biology 2011;102():105-25.
2011: Donald Wlodkowic; Shannon Faley; Zbigniew Darzynkiewicz; Jonathan M Cooper
Real-time cytotoxicity assays.
Methods in molecular biology (Clifton, N.J.) 2011;731():285-91.
2011: Donald Wlodkowic; Joanna Skommer; Zbigniew Darzynkiewicz
Rapid quantification of cell viability and apoptosis in B-cell lymphoma cultures using cyanine SYTO probes.
Methods in molecular biology (Clifton, N.J.) 2011;740():81-9.
2011: Kutluk Oktay; Sumanta Goswami; Zbigniew Darzynkiewicz
Manipulating ovarian aging: a new frontier in fertility preservation.
Aging 2011;3(1):19-21.
2011: Theodore S Nowicki; Hong Zhao; Zbigniew Darzynkiewicz; Augustine L Moscatello; Edward Shin; Stimson Schantz; Raj K Tiwari; Jan Geliebter
Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cells.
Cell cycle (Georgetown, Tex.) 2011;10(1):100-7.
2011: Zbigniew Darzynkiewicz; Piotr Smolewski; Elena Holden; Ed Luther; Mel Henriksen; Maxime François; Wayne Leifert; Michael Fenech
Laser scanning cytometry for automation of the micronucleus assay.
Mutagenesis 2011;26(1):153-61.
2011: Zbigniew Darzynkiewicz; Piotr Pozarowski; Brian W Lee; Gary L Johnson
Fluorochrome-labeled inhibitors of caspases: convenient in vitro and in vivo markers of apoptotic cells for cytometric analysis.
Methods in molecular biology (Clifton, N.J.) 2011;682():103-14.
2011: Zbigniew Darzynkiewicz; Hong Zhao
Detection of DNA strand breaks in apoptotic cells by flow- and image-cytometry.
Methods in molecular biology (Clifton, N.J.) 2011;682():91-101.
2010: Donald Wlodkowic; Zbigniew Darzynkiewicz
Microfluidics: Emerging prospects for anti-cancer drug screening.
World journal of clinical oncology 2010;1(1):18-23.
2010: Hong Zhao; H Dorota Halicka; Frank Traganos; Ellen Jorgensen; Zbigniew Darzynkiewicz
New biomarkers probing depth of cell senescence assessed by laser scanning cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010;77(11):999-1007.
2010: Zbigniew Darzynkiewicz
Cytometry of the cell cycle: In search for perfect methodology for DNA content analysis in tissue specimens.
Cell cycle (Georgetown, Tex.) 2010;9(17):3395-6.
2010: Donald Wlodkowic; Joanna Skommer; Zbigniew Darzynkiewicz
Cytometry in cell necrobiology revisited. Recent advances and new vistas.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010;77(7):591-606.
2010: Zbigniew Darzynkiewicz
Guarding genome integrity in stem cells.
Cell cycle (Georgetown, Tex.) 2010;9(12):2271-2.
2010: Joanna Skommer; Zbigniew Darzynkiewicz; Donald Wlodkowic
Cell death goes LIVE: technological advances in real-time tracking of cell death.
Cell cycle (Georgetown, Tex.) 2010;9(12):2330-41.
2010: Zbigniew Darzynkiewicz
Another "Janus paradox" of p53: induction of cell senescence versus quiescence.
Aging 2010;2(6):329-30.
2010: Ellen D Jorgensen; Hong Zhao; Frank Traganos; Anthony P Albino; Zbigniew Darzynkiewicz
DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes.
Cell cycle (Georgetown, Tex.) 2010;9(11):2170-6.
2010: Maki Ikeda; Akira Kurose; Eriko Takatori; Toru Sugiyama; Frank Traganos; Zbigniew Darzynkiewicz; Takashi Sawai
DNA damage detected with gammaH2AX in endometrioid adenocarcinoma cell lines.
International journal of oncology 2010;36(5):1081-8.
2010: Zbigniew Darzynkiewicz
Critical aspects in analysis of cellular DNA content.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2010;Chapter 7():Unit7.2.
2010: Hong Zhao; Jadwiga Oczos; Pawel Janowski; Dominika Trembecka; Jurek Dobrucki; Zbigniew Darzynkiewicz; Donald Wlodkowic
Rationale for the real-time and dynamic cell death assays using propidium iodide.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010;77(4):399-405.
2010: Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz
Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010;77(3):285-93.
2010: Dorota Pozarowska; Piotr Pozarowski; Zbigniew Darzynkiewicz
Cytometric assessment of cytostatic and cytotoxic effects of topical glaucoma medications on human epithelial corneal line cells.
Cytometry. Part B, Clinical cytometry 2010;78(2):130-7.
2010: Kazuhito Oka; Toshiki Tanaka; Tadahiko Enoki; Koichi Yoshimura; Mako Ohshima; Masayuki Kubo; Tomoyuki Murakami; Toshikazu Gondou; Yoshihide Minami; Yoshihiro Takemoto; Eijirou Harada; Takaaki Tsushimi; Tao-Sheng Li; Frank Traganos; Zbigniew Darzynkiewicz; Kimikazu Hamano
DNA damage signaling is activated during cancer progression in human colorectal carcinoma.
Cancer biology & therapy 2010;9(3):246-52.
2010: Zbigniew Darzynkiewicz; H Dorota Halicka; Hong Zhao
Analysis of cellular DNA content by flow and laser scanning cytometry.
Advances in experimental medicine and biology 2010;676():137-47.
2009: Zbigniew Darzynkiewicz; Frank Traganos; Donald Wlodkowic
Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.
European journal of pharmacology 2009;625(1-3):143-50.
2009: Wojciech Ardelt; Barbara Ardelt; Zbigniew Darzynkiewicz
Ribonucleases as potential modalities in anticancer therapy.
European journal of pharmacology 2009;625(1-3):181-9.
2009: Zbigniew Darzynkiewicz
When senescence masquerades as DNA damage: is DNA replication stress the culprit?
Cell cycle (Georgetown, Tex.) 2009;8(23):3810-1.
2009: Donald Wlodkowic; Joanna Skommer; Dagmara McGuinness; Chris Hillier; Zbigniew Darzynkiewicz
ER-Golgi network--a future target for anti-cancer therapy.
Leukemia research 2009;33(11):1440-7.
2009: H Dorota Halicka; Zbigniew Darzynkiewicz; Laura Teodori
Attenuation of constitutive ATM activation and H2AX phosphorylation in human leukemic TK6 cells by their exposure to static magnetic field.
Cell cycle (Georgetown, Tex.) 2009;8(19):3238-40.
2009: Hong Zhao; Anthony P Albino; Ellen Jorgensen; Frank Traganos; Zbigniew Darzynkiewicz
DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(10):840-7.
2009: Donald Wlodkowic; Joanna Skommer; Dagmara McGuinness; Shannon Faley; Walter Kolch; Zbigniew Darzynkiewicz; Jonathan M Cooper
Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells.
Analytical chemistry 2009;81(16):6952-9.
2009: Anthony P Albino; Ellen D Jorgensen; Patrick Rainey; Gene Gillman; T Jeffrey Clark; Diana Gietl; Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz
gammaH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products.
Mutation research 2009;678(1):43-52.
2009: H Dorota Halicka; Hong Zhao; Monika Podhorecka; Frank Traganos; Zbigniew Darzynkiewicz
Cytometric detection of chromatin relaxation, an early reporter of DNA damage response.
Cell cycle (Georgetown, Tex.) 2009;8(14):2233-7.
2009: H Dorota Halicka; Daniel J Smart; Frank Traganos; Gary M Williams; Zbigniew Darzynkiewicz
Fluoroquinolones lower constitutive H2AX and ATM phosphorylation in TK6 lymphoblastoid cells via modulation of the intracellular redox status.
Pharmacological reports : PR 2009;61(4):711-8.
2009: Zbigniew Darzynkiewicz
Forever young, slim and fit: rapamycin to the rescue.
Cell cycle (Georgetown, Tex.) 2009;8(12):1820-1.
2009: Donald Wlodkowic; Joanna Skommer; Shannon Faley; Zbigniew Darzynkiewicz; Jonathan M Cooper
Dynamic analysis of apoptosis using cyanine SYTO probes: from classical to microfluidic cytometry.
Experimental cell research 2009;315(10):1706-14.
2009: H Dorota Halicka; M Fevzi Ozkaynak; Oya Levendoglu-Tugal; Claudio Sandoval; Karen Seiter; Malgorzata Kajstura; Frank Traganos; Somasunadaram Jayabose; Zbigniew Darzynkiewicz
DNA damage response as a biomarker in treatment of leukemias.
Cell cycle (Georgetown, Tex.) 2009;8(11):1720-4.
2009: Hong Zhao; Frank Traganos; Jurek Dobrucki; Donald Wlodkowic; Zbigniew Darzynkiewicz
Induction of DNA damage response by the supravital probes of nucleic acids.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(6):510-9.
2009: Shoujin Hao; Hong Zhao; Zbigniew Darzynkiewicz; Sailaja Battula; Nicholas R Ferreri
Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells.
American journal of physiology. Renal physiology 2009;296(6):F1494-503.
2009: Zbigniew Darzynkiewicz
An interview with Dr. Zbigniew Darzynkiewicz on his highly cited paper published in Cell Cycle.
Cell cycle (Georgetown, Tex.) 2009;8(10):1471-2.
2009: H Dorota Halicka; Vadim Mitlitski; Julie Heeter; Endre Balazs; Zbigniew Darzynkiewicz
Attenuation of the oxidative burst-induced DNA damage in human leukocytes by hyaluronan.
International journal of molecular medicine 2009;23(5):695-9.
2009: Yuichi Sato; Akira Kurose; Akira Ogawa; Kuniaki Ogasawara; Frank Traganos; Zbigniew Darzynkiewicz; Takashi Sawai
Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide.
Cancer biology & therapy 2009;8(5):452-7.
2009: Zbigniew Darzynkiewicz; Dorota H Halicka; Toshiki Tanaka
Cytometric assessment of DNA damage induced by DNA topoisomerase inhibitors.
Methods in molecular biology (Clifton, N.J.) 2009;582():145-53.
2009: Donald Wlodkowic; Joanna Skommer; Zbigniew Darzynkiewicz
Flow cytometry-based apoptosis detection.
Methods in molecular biology (Clifton, N.J.) 2009;559():19-32.
2009: Toshiki Tanaka; Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs).
Methods in molecular biology (Clifton, N.J.) 2009;523():161-8.
2008: Hong Zhao; Barbara Ardelt; Wojciech Ardelt; Kuslima Shogen; Zbigniew Darzynkiewicz
The cytotoxic ribonuclease onconase targets RNA interference (siRNA).
Cell cycle (Georgetown, Tex.) 2008;7(20):3258-61.
2008: Zbigniew Darzynkiewicz
Pushing cancer cells to commit suicide: is 072RB, the new BH3 mimetic, up to the job?
Cell cycle (Georgetown, Tex.) 2008;7(20):3111.
2008: Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz
Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation.
Cell cycle (Georgetown, Tex.) 2008;7(19):3048-55.
2008: Donald Wlodkowic; Zbigniew Darzynkiewicz
Please do not disturb: destruction of chromatin structure by supravital nucleic acid probes revealed by a novel assay of DNA-histone interaction.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(10):877-9.
2008: Masamichi Ita; H Dorota Halicka; Toshiki Tanaka; Akira Kurose; Barbara Ardelt; Kuslima Shogen; Zbigniew Darzynkiewicz
Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.
Cancer biology & therapy 2008;7(7):1104-8.
2008: W Ardelt; K Shogen; Zbigniew Darzynkiewicz
Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes.
Current pharmaceutical biotechnology 2008;9(3):215-25.
2008: Hong Zhao; Toshiki Tanaka; Vadim Mitlitski; Julie Heeter; Endre Balazs; Zbigniew Darzynkiewicz
Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells.
International journal of oncology 2008;32(6):1159-67.
2008: Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz
Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(6):480-9.
2008: Donald Wlodkowic; Joanna Skommer; Chris Hillier; Zbigniew Darzynkiewicz
Multiparameter detection of apoptosis using red-excitable SYTO probes.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(6):563-9.
2008: Monika Pietrzak; H Dorota Halicka; Zbigniew Wieczorek; Jolanta Wieczorek; Zbigniew Darzynkiewicz
Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin.
Biophysical chemistry 2008;135(1-3):69-75.
2008: Donald Wlodkowic; Joanna Skommer; Zbigniew Darzynkiewicz
SYTO probes in the cytometry of tumor cell death.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(6):496-507.
2008: Hong Zhao; Frank Traganos; Anthony P Albino; Zbigniew Darzynkiewicz
Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation.
Cell cycle (Georgetown, Tex.) 2008;7(10):1490-5.
2008: Daniel J Smart; H Dorota Halicka; Gabriele Schmuck; Frank Traganos; Zbigniew Darzynkiewicz; Gary M Williams
Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone.
Mutation research 2008;641(1-2):43-7.
2008: Zbigniew Darzynkiewicz
There's more than one way to skin a cat: yet another way to assess mitotic index by cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(5):386-7.
2008: Zbigniew Darzynkiewicz
Broken beyond repair. Damaging DNA in glioblastoma cells with radiation and camptothecin.
Cancer biology & therapy 2008;7(3):374-5.
2008: Xiaoxing Wang; Yali Yang; Qing Duan; Ning Jiang; Ying Huang; Zbigniew Darzynkiewicz; Wei Dai
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1.
Developmental cell 2008;14(3):331-41.
2008: Zbigniew Darzynkiewicz; Dariusz Galkowski; Hong Zhao
Analysis of apoptosis by cytometry using TUNEL assay.
Methods (San Diego, Calif.) 2008;44(3):250-4.
2008: Sophie Chen; Jian Gao; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
Down-regulation of androgen-receptor and PSA by phytochemicals.
International journal of oncology 2008;32(2):405-11.
2008: Dorota H Halicka; Masamichi Ita; Toshiki Tanaka; Akira Kurose; Zbigniew Darzynkiewicz
Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage.
Pharmacological reports : PR 2008;60(1):93-100.
2008: Daniel J Smart; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz; Gary M Williams
Ciprofloxacin-induced G2 arrest and apoptosis in TK6 lymphoblastoid cells is not dependent on DNA double-strand break formation.
Cancer biology & therapy 2008;7(1):113-9.
2007: Barbara Ardelt; Wojciech Ardelt; Piotr Pozarowski; Jan Kunicki; Kuslima Shogen; Zbigniew Darzynkiewicz
Cytostatic and cytotoxic properties of Amphinase: a novel cytotoxic ribonuclease from Rana pipiens oocytes.
Cell cycle (Georgetown, Tex.) 2007;6(24):3097-102.
2007: Tze-Chen Hsieh; Frank Traganos; Zbigniew Darzynkiewicz; Joseph Wu
The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells.
International journal of oncology 2007;31(6):1293-300.
2007: Hong Zhao; Toshiki Tanaka; H Dorota Halicka; Frank Traganos; Miroslaw Zarebski; Jurek Dobrucki; Zbigniew Darzynkiewicz
Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(11):905-14.
2007: Kiranmayi Tadi; Badithe T Ashok; Yuangen Chen; Debabrata Banerjee; Barbara Wysocka-Skrzela; Jerzy Konopa; Zbigniew Darzynkiewicz; Raj K Tiwari
Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer.
Cancer biology & therapy 2007;6(10):1632-7.
2007: Barbara Ardelt; Gloria Juan; P Burfeind; T Salomon; Joseph Wu; Tze-Chen Hsieh; X Li; R Sperry; Piotr Pozarowski; Kuslima Shogen; Wojciech Ardelt; Zbigniew Darzynkiewicz
Onconase, an anti-tumor ribonuclease suppresses intracellular oxidative stress.
International journal of oncology 2007;31(3):663-9.
2007: Toshiki Tanaka; Xuan Huang; H Dorota Halicka; Hong Zhao; Frank Traganos; Anthony P Albino; Wei Dai; Zbigniew Darzynkiewicz
Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(9):648-61.
2007: Zbigniew Darzynkiewicz; Piotr Pozarowski
All that glitters is not gold: all that FLICA binds is not caspase. A caution in data interpretation--and new opportunities.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(8):536-7.
2007: Cindy Schulenburg; Barbara Ardelt; Wojciech Ardelt; Ulrich Arnold; Kuslima Shogen; Renate Ulbrich-Hofmann; Zbigniew Darzynkiewicz
The interdependence between catalytic activity, conformational stability, and cytotoxicity of onconase.
Cancer biology & therapy 2007;6(8):1233-9.
2007: H Dorota Halicka; Barbara Ardelt; Kuslima Shogen; Zbigniew Darzynkiewicz
Mild hyperthermia predisposes tumor cells to undergo apoptosis upon treatment with onconase.
International journal of oncology 2007;30(4):841-7.
2007: Malgorzata Kajstura; H Dorota Halicka; Juliusz Pryjma; Zbigniew Darzynkiewicz
Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete "sub-G1" peaks on DNA content histograms.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(3):125-31.
2007: Toshiki Tanaka; H Dorota Halicka; Frank Traganos; Karen Seiter; Zbigniew Darzynkiewicz
Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase.
Cell cycle (Georgetown, Tex.) 2007;6(3):371-6.
2007: Toshiki Tanaka; M Kajstura; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
Cell proliferation 2007;40(1):1-13.
2007: Jane H-C Lin; Takahiro Takano; Gregory Arcuino; Xiaohai Wang; Furong Hu; Zbigniew Darzynkiewicz; Marta Nunes; Steven Goldman; Maiken Nedergaard
Purinergic signaling regulates neural progenitor cell expansion and neurogenesis.
Developmental biology 2007;302(1):356-66.
2007: Toshiki Tanaka; Xuan Huang; Ellen Jorgensen; Diana Gietl; Frank Traganos; Zbigniew Darzynkiewicz; Anthony P Albino
ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.
BMC cell biology 2007;8():26.
2006: Toshiki Tanaka; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.
Cell cycle (Georgetown, Tex.) 2006;5(22):2671-5.
2006: Wlodek Mandecki; Barbara Ardelt; Thomas Coradetti; Hanan Davidowitz; James A AFlint; Zhili Huang; Wesley M MKopacka; Xin Lin; Zhuying Wang; Zbigniew Darzynkiewicz
Microtransponders, the miniature RFID electronic chips, as platforms for cell growth in cytotoxicity assays.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(11):1097-105.
2006: Toshiki Tanaka; H Dorota Halicka; Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants.
Cell cycle (Georgetown, Tex.) 2006;5(17):1940-5.
2006: Monika Pietrzak; Zbigniew Wieczorek; Jolanta Wieczorek; Zbigniew Darzynkiewicz
The "interceptor" properties of chlorophyllin measured within the three-component system: intercalator-DNA-chlorophyllin.
Biophysical chemistry 2006;123(1):11-9.
2006: Toshiki Tanaka; Akira Kurose; Xuan Huang; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status.
Cell proliferation 2006;39(4):313-23.
2006: Toshiki Tanaka; Akira Kurose; H Dorota Halicka; Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species.
Cell cycle (Georgetown, Tex.) 2006;5(15):1669-74.
2006: Xuan Huang; Toshiki Tanaka; Akira Kurose; Frank Traganos; Zbigniew Darzynkiewicz
Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.
International journal of oncology 2006;29(2):495-501.
2006: Xuan Huang; Akira Kurose; Toshiki Tanaka; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine.
Cancer biology & therapy 2006;5(8):959-64.
2006: Y Fang; T Liu; X Wang; Y-M Yang; H Deng; Jan Kunicki; Frank Traganos; Zbigniew Darzynkiewicz; L Lu; W Dai
BubR1 is involved in regulation of DNA damage responses.
Oncogene 2006;25(25):3598-605.
2006: Anthony P Albino; Xuan Huang; Ellen D Jorgensen; Diana Gietl; Frank Traganos; Zbigniew Darzynkiewicz
Induction of DNA double-strand breaks in A549 and normal human pulmonary epithelial cells by cigarette smoke is mediated by free radicals.
International journal of oncology 2006;28(6):1491-505.
2006: Akira Kurose; Toshiki Tanaka; Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage.
Cell proliferation 2006;39(3):231-40.
2006: Nobuharu Fujii; Akio Hiraki; Keisuke Aoe; Tomoyuki Murakami; Kazuma Ikeda; Kozo Masuda; Keitaro Matsuo; Katsuji Shinagawa; Fumihiko Ishimaru; Kazuro Sugi; Zbigniew Darzynkiewicz; Mitsune Tanimoto
Serum cytokine concentrations and acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation: concurrent measurement of ten cytokines and their respective ratios using cytometric bead array.
International journal of molecular medicine 2006;17(5):881-5.
2006: Ning Jiang; Xiaoxing Wang; Meena Jhanwar-Uniyal; Zbigniew Darzynkiewicz; Wei Dai
Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.
The Journal of biological chemistry 2006;281(15):10577-82.
2006: Toshiki Tanaka; Akira Kurose; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX.
Cell cycle (Georgetown, Tex.) 2006;5(8):878-82.
2006: Xuan Huang; Akira Kurose; Toshiki Tanaka; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(4):222-9.
2006: Akira Kurose; Toshiki Tanaka; Xuan Huang; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(4):212-21.
2006: Rakhee S Gupte; Valerie Sampson; Frank Traganos; Zbigniew Darzynkiewicz; Marietta Y W T Lee
Cyclic AMP regulates the expression and nuclear translocation of RFC40 in MCF7 cells.
Experimental cell research 2006;312(6):796-806.
2006: Jun Chen; Xuan Huang; Dorota Halicka; Sergey V Brodsky; Ari Avram; Jonathan Eskander; Noah A Bloomgarden; Zbigniew Darzynkiewicz; Michael S Goligorsky
Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1575-86.
2006: Rakhee S Gupte; Frank Traganos; Zbigniew Darzynkiewicz; Marietta Y W T Lee
Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex.
Cell cycle (Georgetown, Tex.) 2006;5(6):653-60.
2006: Toshiki Tanaka; Akira Kurose; Xuan Huang; Wei Dai; Zbigniew Darzynkiewicz
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.
Cell proliferation 2006;39(1):49-60.
2006: Piotr Pozarowski; Elena Holden; Zbigniew Darzynkiewicz
Laser scanning cytometry: principles and applications.
Methods in molecular biology (Clifton, N.J.) 2006;319():165-92.
2006: Zbigniew Darzynkiewicz; Xuan Huang; Masaki Okafuji
Detection of DNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication).
Methods in molecular biology (Clifton, N.J.) 2006;314():81-93.
2006: Xuan Huang; Zbigniew Darzynkiewicz
Cytometric assessment of histone H2AX phosphorylation: a reporter of DNA damage.
Methods in molecular biology (Clifton, N.J.) 2006;314():73-80.
2005: Hua-Shan Huang; Piotr Pozarowski; Yan Gao; Zbigniew Darzynkiewicz; Ernest Y C Lee
Protein phosphatase-1 inhibitor-3 is co-localized to the nucleoli and centrosomes with PP1gamma1 and PP1alpha, respectively.
Archives of biochemistry and biophysics 2005;443(1-2):33-44.
2005: Kavita Jain; Uzzal Roy; Barbara Ardelt; U Murali Krishna; J R Falck; Piotr Pozarowski; Jan Kunicki; Zbigniew Darzynkiewicz; Michael Balazy
5E, 8Z, 11Z, 14Z-eicosatetraenoic acid, a novel trans isomer of arachidonic acid, causes G1 phase arrest and induces apoptosis of HL-60 cells.
International journal of oncology 2005;27(5):1177-85.
2005: Akira Kurose; Toshiki Tanaka; Xuan Huang; H Dorota Halicka; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;68(1):1-9.
2005: Thomas D Friedrich; Elzbieta Bedner; Zbigniew Darzynkiewicz; John M Lehman
Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;68(1):10-8.
2005: Xuan Huang; H Dorota Halicka; Frank Traganos; Toshiki Tanaka; Akira Kurose; Zbigniew Darzynkiewicz
Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis.
Cell proliferation 2005;38(4):223-43.
2005: Xuan Huang; Wei Dai; Zbigniew Darzynkiewicz
Enforced adhesion of hematopoietic cells to culture dish induces endomitosis and polyploidy.
Cell cycle (Georgetown, Tex.) 2005;4(6):801-5.
2005: Zoya N Demidenko; Dorota H Halicka; Jan Kunicki; James A McCubrey; Zbigniew Darzynkiewicz; Mikhail V Blagosklonny
Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel.
Cancer research 2005;65(10):4401-7.
2005: Rakhee S Gupte; Piotr Pozarowski; Jerzy Grabarek; Frank Traganos; Zbigniew Darzynkiewicz; Marietta Y W T Lee
RIalpha influences cellular proliferation in cancer cells by transporting RFC40 into the nucleus.
Cancer biology & therapy 2005;4(4):429-37.
2005: Sophie Chen; Jian Gao; H Dorota Halicka; Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.
International journal of oncology 2005;26(3):579-88.
2005: H Dorota Halicka; Xuan Huang; Frank Traganos; Malcolm A King; Wei Dai; Zbigniew Darzynkiewicz
Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis.
Cell cycle (Georgetown, Tex.) 2005;4(2):339-45.
2005: Xuan Huang; Brian Lee; Gary Johnson; John Naleway; Anthony Guzikowski; Wei Dai; Zbigniew Darzynkiewicz
Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis.
Cell cycle (Georgetown, Tex.) 2005;4(1):140-7.
2004: Shwu Y Tsai; Barbara Ardelt; Tze-Chen Hsieh; Zbigniew Darzynkiewicz; Kuslima Shogen; Joseph Wu
Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocytoplasmic distribution and reduced expression of transcription factor NF-kappaB.
International journal of oncology 2004;25(6):1745-52.
2004: Malcolm A King; H Dorota Halicka; Zbigniew Darzynkiewicz
Pro- and anti-apoptotic effects of an inhibitor of chymotrypsin-like serine proteases.
Cell cycle (Georgetown, Tex.) 2004;3(12):1566-71.
2004: Zbigniew Darzynkiewicz; Gloria Juan; Edward F Srour
Differential staining of DNA and RNA.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2004;Chapter 7():Unit 7.3.
2004: Xuan Huang; H Dorota Halicka; Zbigniew Darzynkiewicz
Detection of histone H2AX phosphorylation on Ser-139 as an indicator of DNA damage (DNA double-strand breaks).
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2004;Chapter 7():Unit 7.27.
2004: Xuan Huang; Malcolm A King; H Dorota Halicka; Frank Traganos; Masaki Okafuji; Zbigniew Darzynkiewicz
Histone H2AX phosphorylation induced by selective photolysis of BrdU-labeled DNA with UV light: relation to cell cycle phase.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;62(1):1-7.
2004: Yue Fu; Tze-Chen Hsieh; Junqiao Guo; Jan Kunicki; Marietta Y W T Lee; Zbigniew Darzynkiewicz; Joseph Wu
Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells.
Biochemical and biophysical research communications 2004;322(1):263-70.
2004: Mikhail V Blagosklonny; Zbigniew Darzynkiewicz; H Dorota Halicka; Piotr Pozarowski; Zoya N Demidenko; James J Barry; Kalpana R Kamath; Robert Herrmann
Paclitaxel induces primary and postmitotic G1 arrest in human arterial smooth muscle cells.
Cell cycle (Georgetown, Tex.) 2004;3(8):1050-6.
2004: Anthony P Albino; Xuan Huang; Ellen D Jorgensen; J Yang; Diana Gietl; Frank Traganos; Zbigniew Darzynkiewicz
Induction of H2AX phosphorylation in pulmonary cells by tobacco smoke: a new assay for carcinogens.
Cell cycle (Georgetown, Tex.) 2004;3(8):1062-8.
2004: Xuan Huang; Qin Ruan; Yuqiang Fang; Frank Traganos; Zbigniew Darzynkiewicz; Wei Dai
Physical and functional interactions between mitotic kinases during polyploidization and megakaryocytic differentiation.
Cell cycle (Georgetown, Tex.) 2004;3(7):946-51.
2004: Gloria Juan; Zbigniew Darzynkiewicz
Detection of mitotic cells.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2004;Chapter 7():Unit 7.24.
2004: Zbigniew Darzynkiewicz; Xuan Huang
Analysis of cellular DNA content by flow cytometry.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2004;Chapter 5():Unit 5.7.
2004: Akio Hiraki; Nobuharu Fujii; Tomoyuki Murakami; Katsuyuki Kiura; Keisuke Aoe; Hiromichi Yamane; Kozo Masuda; Tadashi Maeda; Kazuro Sugi; Zbigniew Darzynkiewicz; Mitsune Tanimoto; Mine Harada
High frequency of allele-specific down-regulation of HLA class I expression in lung cancer cell lines.
Anticancer research 2004;24(3a):1525-8.
2004: Xuan Huang; Masaki Okafuji; Frank Traganos; Ed Luther; Elena Holden; Zbigniew Darzynkiewicz
Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;58(2):99-110.
2004: Qin Ruan; Qi Wang; Suqing Xie; Yuqiang Fang; Zbigniew Darzynkiewicz; Kunliang Guan; Meena Jhanwar-Uniyal; Wei Dai
Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle.
Experimental cell research 2004;294(1):51-9.
2004: Zbigniew Darzynkiewicz; Harry Crissman; James Jacobberger
Cytometry of the cell cycle: cycling through history.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;58(1):21-32.
2004: Qi Wang; Tongyi Liu; Yuqiang Fang; Suqing Xie; Xuan Huang; Radma Mahmood; Gita Ramaswamy; Kathleen M Sakamoto; Zbigniew Darzynkiewicz; Ming Xu; Wei Dai
BUBR1 deficiency results in abnormal megakaryopoiesis.
Blood 2004;103(4):1278-85.
2004: Piotr Pozarowski; Jerzy Grabarek; Zbigniew Darzynkiewicz
Flow cytometry of apoptosis.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2004;Chapter 18():Unit 18.8.
2004: Piotr Pozarowski; Xuan Huang; Richard W Gong; Waldemar Priebe; Zbigniew Darzynkiewicz
Simple, semiautomatic assay of cytostatic and cytotoxic effects of antitumor drugs by laser scanning cytometry: effects of the bis-intercalator WP631 on growth and cell cycle of T-24 cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;57(2):113-9.
2004: Zbigniew Darzynkiewicz; Xuan Huang; Masaki Okafuji; Malcolm A King
Cytometric methods to detect apoptosis.
Methods in cell biology 2004;75():307-41.
2004: Mario Roederer; Zbigniew Darzynkiewicz; David R Parks
Guidelines for the presentation of flow cytometric data.
Methods in cell biology 2004;75():241-56.
2004: Krzysztof Jamroziak; Piotr Smolewski; Barbara Cebula; Anna Szmigielska-Kaplon; Zbigniew Darzynkiewicz; Tadeusz Robak
Relation of P-glycoprotein expression with spontaneous in vitro apoptosis in B-cell chronic lymphocytic leukemia.
Neoplasma 2004;51(3):181-7.
2004: Piotr Pozarowski; Zbigniew Darzynkiewicz
Analysis of cell cycle by flow cytometry.
Methods in molecular biology (Clifton, N.J.) 2004;281():301-11.
2004: Elzbieta Smolewska; H Brózik; Piotr Smolewski; Zbigniew Darzynkiewicz; J Stańczyk
Regulation of peripheral blood and synovial fluid lymphocyte apoptosis in juvenile idiopathic arthritis.
Scandinavian journal of rheumatology 2004;33(1):7-12.
2003: Brian W Lee; Gary L Johnson; Sally A Hed; Zbigniew Darzynkiewicz; Jamil W Talhouk; Sanjiv Mehrotra
DEVDase detection in intact apoptotic cells using the cell permeant fluorogenic substrate, (z-DEVD)2-cresyl violet.
BioTechniques 2003;35(5):1080-5.
2003: Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis.
Cell cycle (Georgetown, Tex.) 2003;2(6):614-9.
2003: Nader G Abraham; Taketoshi Kushida; Jack McClung; Melvin Weiss; Shuo Quan; Rocky Lafaro; Zbigniew Darzynkiewicz; Michael Wolin
Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells.
Circulation research 2003;93(6):507-14.
2003: Piotr Pozarowski; Xuan Huang; Dorota H Halicka; B Lee; G Johnson; Zbigniew Darzynkiewicz
Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;55(1):50-60.
2003: Asifa S Haider; Irene Lee; Jerzy Grabarek; Zbigniew Darzynkiewicz; Nicholas R Ferreri
Dual functionality of cyclooxygenase-2 as a regulator of tumor necrosis factor-mediated G1 shortening and nitric oxide-mediated inhibition of vascular smooth muscle cell proliferation.
Circulation 2003;108(8):1015-21.
2003: Piotr Pozarowski; Jerzy Grabarek; Zbigniew Darzynkiewicz
Flow cytometry of apoptosis.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2003;Chapter 7():Unit 7.19.
2003: Piotr Pozarowski; Dorota H Halicka; Zbigniew Darzynkiewicz
NF-kappaB inhibitor sesquiterpene parthenolide induces concurrently atypical apoptosis and cell necrosis: difficulties in identification of dead cells in such cultures.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;54(2):118-24.
2003: Elzbieta Smolewska; H Brozik; Piotr Smolewski; M Biernacka-Zielinska; Zbigniew Darzynkiewicz; Jerzy Stanczyk
Apoptosis of peripheral blood lymphocytes in patients with juvenile idiopathic arthritis.
Annals of the rheumatic diseases 2003;62(8):761-3.
2003: Keisuke Aoe; Akio Hiraki; Tomoyuki Murakami; Kazuo Murakami; Kiyoshi Makihata; Kazushi Takao; Ryosuke Eda; Tadashi Maeda; Kazuro Sugi; Zbigniew Darzynkiewicz; Hiroyasu Takeyama
Relative abundance and patterns of correlation among six cytokines in pleural fluid measured by cytometric bead array.
International journal of molecular medicine 2003;12(2):193-8.
2003: Piotr Smolewski; Zbigniew Darzynkiewicz; Tadeusz Robak
Caspase-mediated cell death in hematological malignancies: theoretical considerations, methods of assessment, and clinical implications.
Leukemia & lymphoma 2003;44(7):1089-104.
2003: Piotr Pozarowski; Dorota H Halicka; Zbigniew Darzynkiewicz
Cell cycle effects and caspase-dependent and independent death of HL-60 and Jurkat cells treated with the inhibitor of NF-kappaB parthenolide.
Cell cycle (Georgetown, Tex.) 2003;2(4):377-83.
2003: Monika Pietrzak; Zbigniew Wieczorek; Alicja Stachelska; Zbigniew Darzynkiewicz
Interactions of chlorophyllin with acridine orange, quinacrine mustard and doxorubicin analyzed by light absorption and fluorescence spectroscopy.
Biophysical chemistry 2003;104(1):305-13.
2003: Asifa S Haider; Jerzy Grabarek; Ben Eng; Paulina Pedraza; Nicholas R Ferreri; Endre Balazs; Zbigniew Darzynkiewicz
In vitro model of "wound healing" analyzed by laser scanning cytometry: accelerated healing of epithelial cell monolayers in the presence of hyaluronate.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;53(1):1-8.
2003: Mikhail V Blagosklonny; Zbigniew Darzynkiewicz
Why Iressa failed: toward novel use of kinase inhibitors (outlook).
Cancer biology & therapy 2003;2(2):137-40.
2003: Zbigniew Darzynkiewicz; Gloria Juan; Frank Traganos
Cytometry of cell cycle regulatory proteins.
Progress in cell cycle research 2003;5():533-42.
2003: Barbara Ardelt; Wojciech Ardelt; Zbigniew Darzynkiewicz
Cytotoxic ribonucleases and RNA interference (RNAi).
Cell cycle (Georgetown, Tex.) 2003;2(1):22-4.
2003: Annabel Strife; David Wisniewski; Chongyuan Liu; Caryl L Lambek; Zbigniew Darzynkiewicz; Richard T Silver; Bayard Clarkson
Direct evidence that Bcr-Abl tyrosine kinase activity disrupts normal synergistic interactions between Kit ligand and cytokines in primary primitive progenitor cells.
Molecular cancer research : MCR 2003;1(3):176-85.
2002: Dorota H Halicka; Piotr Pozarowski; M Ita; Wojciech Ardelt; Stanislaw M Mikulski; Kuslima Shogen; Zbigniew Darzynkiewicz
Enhancement of activation-induced apoptosis of lymphocytes by the cytotoxic ribonuclease onconase (Ranpirnase).
International journal of oncology 2002;21(6):1245-50.
2002: Mikhail V Blagosklonny; Zbigniew Darzynkiewicz
Cyclotherapy: protection of normal cells and unshielding of cancer cells.
Cell cycle (Georgetown, Tex.) 2002;1(6):375-82.
2002: Laura Teodori; Jerzy Grabarek; Piotr Smolewski; Lina Ghibelli; Antonio Bergamaschi; Milena De Nicola; Zbigniew Darzynkiewicz
Exposure of cells to static magnetic field accelerates loss of integrity of plasma membrane during apoptosis.
Cytometry 2002;49(3):113-8.
2002: Tze Hsieh; Dorota H Halicka; Xiaohua Lu; Jan Kunicki; Junqiao Guo; Zbigniew Darzynkiewicz; Joseph Wu
Effects of resveratrol on the G(0)-G(1) transition and cell cycle progression of mitogenically stimulated human lymphocytes.
Biochemical and biophysical research communications 2002;297(5):1311-7.
2002: Tze-Chen Hsieh; Jan Kunicki; Zbigniew Darzynkiewicz; Joseph Wu
Effects of extracts of Coriolus versicolor (I'm-Yunity) on cell-cycle progression and expression of interleukins-1 beta,-6, and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes.
Journal of alternative and complementary medicine (New York, N.Y.) 2002;8(5):591-602.
2002: Jerzy Grabarek; Barbara Ardelt; Jan Kunicki; Zbigniew Darzynkiewicz
Detection of in situ activation of transglutaminase during apoptosis: correlation with the cell cycle phase by multiparameter flow and laser scanning cytometry.
Cytometry 2002;49(2):83-9.
2002: Mikhail V Blagosklonny; Robert Robey; Dan L Sackett; Litong Du; Frank Traganos; Zbigniew Darzynkiewicz; Tito Fojo; Susan E Bates
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.
Molecular cancer therapeutics 2002;1(11):937-41.
2002: Zbigniew Darzynkiewicz
One more reason to get arrested (in G1).
Cell cycle (Georgetown, Tex.) 2002;1(5):318-9.
2002: Suqing Xie; Qi Wang; Lu Luo; Qin Ruan; Tongyi Liu; Meena Jhanwar-Uniyal; Zbigniew Darzynkiewicz; Frank Traganos; Wei Dai
Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(9):957-63.
2002: Jerzy Grabarek; Zbigniew Darzynkiewicz
In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors.
Experimental hematology 2002;30(9):982-9.
2002: Jerzy Grabarek; Barbara Ardelt; Litong Du; Zbigniew Darzynkiewicz
Activation of caspases and serine proteases during apoptosis induced by onconase (Ranpirnase).
Experimental cell research 2002;278(1):61-71.
2002: Mikhail V Blagosklonny; Zbigniew Darzynkiewicz; William D Figg
Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel.
Cancer biology & therapy 2002;1(4):420-5.
2002: Mikhail V Blagosklonny; Zbigniew Darzynkiewicz
Four birds with one stone: RAPA as potential anticancer therapy.
Cancer biology & therapy 2002;1(4):359-61.
2002: Tze-Chen Hsieh; Wen Xiong; Frank Traganos; Zbigniew Darzynkiewicz; Joseph Wu
Effects of PC-SPES on proliferation and expression of AR/PSA in androgen-responsive LNCaP cells are independent of estradiol.
Anticancer research 2002;22(4):2051-60.
2002: Piotr Smolewski; Jerzy Grabarek; H Dorota Halicka; Zbigniew Darzynkiewicz
Assay of caspase activation in situ combined with probing plasma membrane integrity to detect three distinct stages of apoptosis.
Journal of immunological methods 2002;265(1-2):111-21.
2002: Wojciech Gorczyca; James Weisberger; Zach Liu; Patricia Tsang; Monowar Hossein; C Daniel Wu; Henry Dong; John Y L Wong; Sorina Tugulea; Simpson Dee; Myron R Melamed; Zbigniew Darzynkiewicz
An approach to diagnosis of T-cell lymphoproliferative disorders by flow cytometry.
Cytometry 2002;50(3):177-90.
2002: H Dorota Halicka; Piotr Smolewski; Zbigniew Darzynkiewicz; Wei Dai; Frank Traganos
Arsenic trioxide arrests cells early in mitosis leading to apoptosis.
Cell cycle (Georgetown, Tex.) 2002;1(3):201-9.
2002: Qi Wang; Suqing Xie; Jie Chen; Kenji Fukasawa; Ulhas Naik; Frank Traganos; Zbigniew Darzynkiewicz; Meena Jhanwar-Uniyal; Wei Dai
Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.
Molecular and cellular biology 2002;22(10):3450-9.
2002: S Y Tsai; Tze-Chen Hsieh; Barbara Ardelt; Zbigniew Darzynkiewicz; Joseph Wu
Combined effects of onconase and IFN-beta on proliferation, macromolecular syntheses and expression of STAT-1 in JCA-1 cancer cells.
International journal of oncology 2002;20(5):891-6.
2002: Tze-Chen Hsieh; Xiaohua Lu; Junqiao Guo; Wen Xiong; Jan Kunicki; Zbigniew Darzynkiewicz; Joseph Wu
Effects of herbal preparation Equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells: mechanistic studies.
International journal of oncology 2002;20(4):681-9.
2002: Jerzy Grabarek; Litong Du; Gary L Johnson; Brian W Lee; David J Phelps; Zbigniew Darzynkiewicz
Sequential activation of caspases and serine proteases (serpases) during apoptosis.
Cell cycle (Georgetown, Tex.) 2002;1(2):124-31.
2002: Jerzy Grabarek; Paul Amstad; Zbigniew Darzynkiewicz
Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases.
Human cell 2002;15(1):1-12.
2002: Piotr Smolewski; Jerzy Grabarek; Brian W Lee; Gary L Johnson; Zbigniew Darzynkiewicz
Kinetics of HL-60 cell entry to apoptosis during treatment with TNF-alpha or camptothecin assayed by the stathmo-apoptosis method.
Cytometry 2002;47(3):143-9.
2002: Jan Kapuscinski; Barbara Ardelt; Jacek Piosik; Malgorzata Zdunek; Zbigniew Darzynkiewicz
The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine.
Biochemical pharmacology 2002;63(4):625-34.
2002: Jerzy Grabarek; Michal Dragan; Brian W Lee; Gary L Johnson; Zbigniew Darzynkiewicz
Activation of chymotrypsin-like serine protease(s) during apoptosis detected by affinity-labeling of the enzymatic center with fluoresceinated inhibitor.
International journal of oncology 2002;20(2):225-33.
2002: Florence C Guibal; Christel Moog-Lutz; Piotr Smolewski; Yolande Di Gioia; Zbigniew Darzynkiewicz; Pierre G Lutz; Yvon E Cayre
ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells.
The Journal of biological chemistry 2002;277(1):218-24.
2002: Zbigniew Darzynkiewicz; Elzbieta Bedner; Piotr Smolewski
In situ detection of DNA strand breaks in analysis of apoptosis by flow- and laser-scanning cytometry.
Methods in molecular biology (Clifton, N.J.) 2002;203():69-77.
2002: Zbigniew Darzynkiewicz; Elzbieta Bedner; Piotr Smolewski; Brian W Lee; Gary L Johnson
Detection of caspases activation in situ by fluorochrome-labeled inhibitors of caspases (FLICA).
Methods in molecular biology (Clifton, N.J.) 2002;203():289-99.
2001: Zbigniew Darzynkiewicz; Piotr Smolewski; Elzbieta Bedner
Use of flow and laser scanning cytometry to study mechanisms regulating cell cycle and controlling cell death.
Clinics in laboratory medicine 2001;21(4):857-73.
2001: Wojciech Gorczyca; Piotr Smolewski; Jerzy Grabarek; Barbara Ardelt; M Ita; Myron R Melamed; Zbigniew Darzynkiewicz
Morphometry of nucleoli and expression of nucleolin analyzed by laser scanning cytometry in mitogenically stimulated lymphocytes.
Cytometry 2001;45(3):206-13.
2001: S Chen; Q Ruan; Elzbieta Bedner; A Deptala; X Wang; Tze-Chen Hsieh; Frank Traganos; Zbigniew Darzynkiewicz
Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines.
Cell proliferation 2001;34(5):293-304.
2001: L Du; Piotr Smolewski; Elzbieta Bedner; Frank Traganos; Zbigniew Darzynkiewicz
Selective protection of mitogenically stimulated human lymphocytes but not leukemic cells from cytosine arabinoside-induced apoptosis by LY294002, a phosphoinositol-3 kinase inhibitor.
International journal of oncology 2001;19(4):811-9.
2001: Piotr Smolewski; Jerzy Grabarek; David J Phelps; Zbigniew Darzynkiewicz
Stathmo-apoptosis: arresting apoptosis by fluorochrome-labeled inhibitor of caspases.
International journal of oncology 2001;19(4):657-63.
2001: Jurek Dobrucki; Zbigniew Darzynkiewicz
Chromatin condensation and sensitivity of DNA in situ to denaturation during cell cycle and apoptosis--a confocal microscopy study.
Micron (Oxford, England : 1993) 2001;32(7):645-52.
2001: Piotr Smolewski; Jerzy Grabarek; L A Kamentsky; Zbigniew Darzynkiewicz
Bivariate analysis of cellular DNA versus RNA content by laser scanning cytometry using the product of signal subtraction (differential fluorescence) as a separate parameter.
Cytometry 2001;45(1):73-8.
2001: Piotr Smolewski; Q Ruan; L Vellon; Zbigniew Darzynkiewicz
Micronuclei assay by laser scanning cytometry.
Cytometry 2001;45(1):19-26.
2001: Piotr Smolewski; Elzbieta Bedner; Wojciech Gorczyca; Zbigniew Darzynkiewicz
"Liquidless" cell staining by dye diffusion from gels and analysis by laser scanning cytometry: potential application at microgravity conditions in space.
Cytometry 2001;44(4):355-60.
2001: Annarosa Leri; Laura Barlucchi; Federica Limana; A Deptala; Zbigniew Darzynkiewicz; Thomas H Hintze; Jan Kajstura; Bernardo Nadal-Ginard; Piero Anversa
Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8626-31.
2001: Gloria Juan; Zbigniew Darzynkiewicz
Bivariate analysis of DNA content and expression of cyclin proteins.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.9.
2001: Zbigniew Darzynkiewicz; Gloria Juan
Analysis of DNA denaturation.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.8.
2001: Zbigniew Darzynkiewicz; Gloria Juan
Analysis of DNA content and BrdU incorporation.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.7.
2001: Zbigniew Darzynkiewicz; Gloria Juan
DNA content measurement for DNA ploidy and cell cycle analysis.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.5.
2001: Zbigniew Darzynkiewicz; Gloria Juan
Analysis of DNA content and DNA strand breaks for detection of apoptotic cells.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.4.
2001: Zbigniew Darzynkiewicz; Gloria Juan
Overview of nucleic acid analysis.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.1.
2001: Zbigniew Darzynkiewicz; Gloria Juan; Elzbieta Bedner
Determining cell cycle stages by flow cytometry.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 8():Unit 8.4.
2001: Piotr Smolewski; Elzbieta Bedner; Litong Du; Tze-Chen Hsieh; Joseph Wu; David J Phelps; Zbigniew Darzynkiewicz
Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry.
Cytometry 2001;44(1):73-82.
2001: Zbigniew Darzynkiewicz; Elzbieta Bedner; Piotr Smolewski
Flow cytometry in analysis of cell cycle and apoptosis.
Seminars in hematology 2001;38(2):179-93.
2001: Barbara Ardelt; Jan Kunicki; Frank Traganos; Zbigniew Darzynkiewicz
Chlorophyllin protects cells from the cytostatic and cytotoxic effects of quinacrine mustard but not of nitrogen mustard.
International journal of oncology 2001;18(4):849-53.
2001: Zbigniew Darzynkiewicz; Xuguang Li; Elzbieta Bedner
Use of flow and laser-scanning cytometry in analysis of cell death.
Methods in cell biology 2001;66():69-109.
2001: A Deptala; Elzbieta Bedner; Zbigniew Darzynkiewicz
Unique analytical capabilities of laser scanning cytometry (LSC) that complement flow cytometry.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 2001;39(2):87-9.
2001: Elzbieta Bedner; Litong Du; Frank Traganos; Zbigniew Darzynkiewicz
Caffeine dissociates complexes between DNA and intercalating dyes: application for bleaching fluorochrome-stained cells for their subsequent restaining and analysis by laser scanning cytometry.
Cytometry 2001;43(1):38-45.
2001: Zbigniew Darzynkiewicz; Gloria Juan; Frank Traganos
Assaying drug-induced apoptosis.
Methods in molecular biology (Clifton, N.J.) 2001;95():241-54.
2001: Frank Traganos; Gloria Juan; Zbigniew Darzynkiewicz
Cell-cycle analysis of drug-treated cells.
Methods in molecular biology (Clifton, N.J.) 2001;95():229-40.
2001: Wojciech Gorczyca; A Deptala; Elzbieta Bedner; Xuguang Li; Myron R Melamed; Zbigniew Darzynkiewicz
Analysis of human tumors by laser scanning cytometry.
Methods in cell biology 2001;64():421-43.
2001: Zbigniew Darzynkiewicz; Elzbieta Bedner; Frank Traganos
Difficulties and pitfalls in analysis of apoptosis.
Methods in cell biology 2001;63():527-46.
2001: Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz
Methods to identify mitotic cells by flow cytometry.
Methods in cell biology 2001;63():343-54.
2000: H Dorota Halicka; T Murakami; C N Papageorgio; Abraham Mittelman; Stanislaw M Mikulski; Kuslima Shogen; Zbigniew Darzynkiewicz
Induction of differentiation of leukaemic (HL-60) or prostate cancer (LNCaP, JCA-1) cells potentiates apoptosis triggered by onconase.
Cell proliferation 2000;33(6):407-17.
2000: Jing-Chuan Zhang; K Claffey; Ramasamy Sakthivel; Zbigniew Darzynkiewicz; David E Shaw; J Leal; Y C Wang; F M Lu; Keith R McCrae
Two-chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity within domain 5.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2589-600.
2000: James Weisberger; C Daniel Wu; Zach Liu; John Y L Wong; Myron R Melamed; Zbigniew Darzynkiewicz; Wojciech Gorczyca
Differential diagnosis of malignant lymphomas and related disorders by specific pattern of expression of immunophenotypic markers revealed by multiparameter flow cytometry (Review).
International journal of oncology 2000;17(6):1165-77.
2000: H Dorota Halicka; Elzbieta Bedner; Zbigniew Darzynkiewicz
Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis.
Experimental cell research 2000;260(2):248-56.
2000: I Abdel-Moneim; Myron R Melamed; Zbigniew Darzynkiewicz; Wojciech Gorczyca
Proliferation and apoptosis in solid tumors. Analysis by laser scanning cytometry.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 2000;22(5):393-7.
2000: Elzbieta Bedner; Xuguang Li; Jan Kunicki; Zbigniew Darzynkiewicz
Translocation of Bax to mitochondria during apoptosis measured by laser scanning cytometry.
Cytometry 2000;41(2):83-8.
2000: Zbigniew Darzynkiewicz; F Traganos; J M Wu; S Chen
Chinese herbal mixture PC SPES in treatment of prostate cancer (review).
International journal of oncology 2000;17(4):729-36.
2000: Elzbieta Bedner; Piotr Smolewski; Paul Amstad; Zbigniew Darzynkiewicz
Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation.
Experimental cell research 2000;259(1):308-13.
2000: AM DiPietrantonio; Tze-Chen Hsieh; Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz; Joseph Wu
Fenretinide-induced caspase 3 activity involves increased protein stability in a mechanism distinct from reactive oxygen species elevation.
Cancer research 2000;60(16):4331-5.
2000: Anthony P Albino; G Juan; Frank Traganos; L Reinhart; J Connolly; David P Rose; Zbigniew Darzynkiewicz
Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation.
Cancer research 2000;60(15):4139-45.
2000: Elzbieta Bedner; Q Ruan; S Chen; L A Kamentsky; Zbigniew Darzynkiewicz
Multiparameter analysis of progeny of individual cells by laser scanning cytometry.
Cytometry 2000;40(4):271-9.
2000: Zbigniew Darzynkiewicz
Re: preclinical and clinical development of cyclin-dependent kinase modulators.
Journal of the National Cancer Institute 2000;92(14):1184-5.
2000: Eric J Feldman; Karen Seiter; Frank Traganos; Zbigniew Darzynkiewicz; H Goff; M Pozzuoli; Paul Baskind; S Santos; Tauseef Ahmed
Phase II evaluation of a high-dose mitoxantrone based induction regimen in untreated adults with acute myeloid leukemia.
Leukemia & lymphoma 2000;38(3-4):309-15.
2000: Xuguang Li; Litong Du; Zbigniew Darzynkiewicz
During apoptosis of HL-60 and U-937 cells caspases are activated independently of dissipation of mitochondrial electrochemical potential.
Experimental cell research 2000;257(2):290-7.
2000: C W Lin; Zbigniew Darzynkiewicz; Xuguang Li; Frank Traganos; Elzbieta Bedner; Yuk-Ching Tse-Dinh
Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes.
Experimental cell research 2000;256(1):225-36.
2000: Jan Kajstura; Barbara Pertoldi; Annarosa Leri; Carlo Alberto Beltrami; A Deptala; Zbigniew Darzynkiewicz; Piero Anversa
Telomere shortening is an in vivo marker of myocyte replication and aging.
The American journal of pathology 2000;156(3):813-9.
2000: Xuguang Li; Zbigniew Darzynkiewicz
Cleavage of Poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis.
Experimental cell research 2000;255(1):125-32.
2000: Zbigniew Darzynkiewicz; Elzbieta Bedner
Analysis of apoptotic cells by flow and laser scanning cytometry.
Methods in enzymology 2000;322():18-39.
2000: Karen Seiter; Eric J Feldman; H Dorota Halicka; A Deptala; Frank Traganos; Harry B Burke; A Hoang; H Goff; M Pozzuoli; Ram Kancherla; Zbigniew Darzynkiewicz; Tauseef Ahmed
Clinical and laboratory evaluation of all-trans retinoic acid modulation of chemotherapy in patients with acute myelogenous leukaemia.
British journal of haematology 2000;108(1):40-7.
1999: A Deptala; Xuguang Li; Elzbieta Bedner; W Cheng; Frank Traganos; Zbigniew Darzynkiewicz
Differences in induction of p53, p21WAF1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin.
International journal of oncology 1999;15(5):861-71.
1999: Tze-Chen Hsieh; P Burfeind; K Laud; J M Backer; Frank Traganos; Zbigniew Darzynkiewicz; Joseph Wu
Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials.
International journal of oncology 1999;15(2):245-52.
1999: Xuguang Li; Zbigniew Darzynkiewicz
The Schrödinger's cat quandary in cell biology: integration of live cell functional assays with measurements of fixed cells in analysis of apoptosis.
Experimental cell research 1999;249(2):404-12.
1999: Tze-Chen Hsieh; Gloria Juan; Zbigniew Darzynkiewicz; Joseph Wu
Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2.
Cancer research 1999;59(11):2596-601.
1999: Zbigniew Darzynkiewicz; Elzbieta Bedner; Xuguang Li; Wojciech Gorczyca; Myron R Melamed
Laser-scanning cytometry: A new instrumentation with many applications.
Experimental cell research 1999;249(1):1-12.
1999: Elzbieta Bedner; H Dorota Halicka; W Cheng; T Salomon; A Deptala; Wojciech Gorczyca; Myron R Melamed; Zbigniew Darzynkiewicz
High affinity binding of fluorescein isothiocyanate to eosinophils detected by laser scanning cytometry: a potential source of error in analysis of blood samples utilizing fluorescein-conjugated reagents in flow cytometry.
Cytometry 1999;36(1):77-82.
1999: L Tan; M Anna Kowalska; Gabriel M Romo; Jose A Lopez; Zbigniew Darzynkiewicz; Stefan Niewiarowski
Identification and characterization of endothelial glycoprotein Ib using viper venom proteins modulating cell adhesion.
Blood 1999;93(8):2605-16.
1999: Elzbieta Bedner; Xuguang Li; Wojciech Gorczyca; Myron R Melamed; Zbigniew Darzynkiewicz
Analysis of apoptosis by laser scanning cytometry.
Cytometry 1999;35(3):181-95.
1999: G Del Bino; Zbigniew Darzynkiewicz; Chantal Degraef; Roger Mosselmans; D Fokan; P Galand
Comparison of methods based on annexin-V binding, DNA content or TUNEL for evaluating cell death in HL-60 and adherent MCF-7 cells.
Cell proliferation 1999;32(1):25-37.
1999: Zbigniew Darzynkiewicz
The butler did it: search for killer(s) of Kaposi's sarcoma cells in preparations of human chorionic gonadotropin.
Journal of the National Cancer Institute 1999;91(2):104-6.
1999: Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz
Histone H3 phosphorylation in human monocytes and during HL-60 cell differentiation.
Experimental cell research 1999;246(1):212-20.
1999: Zbigniew Darzynkiewicz; Xuguang Li; Elzbieta Bedner
Detection of DNA strand breakage in the analysis of apoptosis and cell proliferation by flow and laser scanning cytometry.
Methods in molecular biology (Clifton, N.J.) 1999;113():607-19.
1999: Zbigniew Darzynkiewicz; Gloria Juan
Selective extraction of fragmented DNA from apoptotic cells for analysis by gel electrophoresis and identification of apoptotic cells by flow cytometry.
Methods in molecular biology (Clifton, N.J.) 1999;113():599-605.
1998: Wojciech Gorczyca; M Davidian; J Gherson; R Ashikari; Zbigniew Darzynkiewicz; Myron R Melamed
Laser scanning cytometry quantification of estrogen receptors in breast cancer.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1998;20(6):470-6.
1998: Wojciech Gorczyca; Elzbieta Bedner; P Burfeind; Zbigniew Darzynkiewicz; Myron R Melamed
Analysis of apoptosis in solid tumors by laser-scanning cytometry.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1998;11(11):1052-8.
1998: Eric J Feldman; Karen Seiter; J W Chiao; H Dorota Halicka; F Traganos; S R Fatora; J McMichael; Paul Baskind; H Goff; M Beer; Tauseef Ahmed; Zbigniew Darzynkiewicz
In vitro effects and clinical evaluation of a human chorionic gonadotrophin preparation in acute leukemia.
Leukemia 1998;12(11):1749-55.
1998: A Deptala; Elzbieta Bedner; Wojciech Gorczyca; Zbigniew Darzynkiewicz
Activation of nuclear factor kappa B (NF-kappaB) assayed by laser scanning cytometry (LSC).
Cytometry 1998;33(3):376-82.
1998: Gloria Juan; Xuguang Li; Zbigniew Darzynkiewicz
Phosphorylation of retinoblastoma protein assayed in individual HL-60 cells during their proliferation and differentiation.
Experimental cell research 1998;244(1):83-92.
1998: Stanislaw M Mikulski; A Viera; A Deptala; Zbigniew Darzynkiewicz
Enhanced in vitro cytotoxicity and cytostasis of the combination of onconase with a proteasome inhibitor.
International journal of oncology 1998;13(4):633-44.
1998: Elzbieta Bedner; P Burfeind; Tze-Chen Hsieh; Joseph Wu; Maria E Aguero-Rosenfeld; Myron R Melamed; Harold W Horowitz; Gary P Wormser; Zbigniew Darzynkiewicz
Cell cycle effects and induction of apoptosis caused by infection of HL-60 cells with human granulocytic ehrlichiosis pathogen measured by flow and laser scanning cytometry.
Cytometry 1998;33(1):47-55.
1998: Elzbieta Bedner; Myron R Melamed; Zbigniew Darzynkiewicz
Enzyme kinetic reactions and fluorochrome uptake rates measured in individual cells by laser scanning cytometry.
Cytometry 1998;33(1):1-9.
1998: Gloria Juan; Barbara Ardelt; X Li; Stanislaw M Mikulski; Kuslima Shogen; Wojciech Ardelt; Abraham Mittelman; Zbigniew Darzynkiewicz
G1 arrest of U937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16INK4A, p21WAF1/CIP1 and p27KIP and decreased pRb phosphorylation.
Leukemia 1998;12(8):1241-8.
1998: A Deptala; H Dorota Halicka; Barbara Ardelt; Wojciech Ardelt; Stanislaw M Mikulski; Kuslima Shogen; Zbigniew Darzynkiewicz
Potentiation of tumor necrosis factor induced apoptosis by onconase.
International journal of oncology 1998;13(1):11-6.
1998: Gloria Juan; Frank Traganos; W M James; JM Ray; Michel Roberge; D M Sauve; H Anderson; Zbigniew Darzynkiewicz
Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis.
Cytometry 1998;32(2):71-7.
1998: Zbigniew Darzynkiewicz; Elzbieta Bedner; Frank Traganos; T Murakami
Critical aspects in the analysis of apoptosis and necrosis.
Human cell 1998;11(1):3-12.
1998: Gloria Juan; S Gruenwald; Zbigniew Darzynkiewicz
Phosphorylation of retinoblastoma susceptibility gene protein assayed in individual lymphocytes during their mitogenic stimulation.
Experimental cell research 1998;239(1):104-10.
1998: Zbigniew Darzynkiewicz; Frank Traganos
Measurement of apoptosis.
Advances in biochemical engineering/biotechnology 1998;62():33-73.
1998: Wojciech Gorczyca; Myron R Melamed; Zbigniew Darzynkiewicz
Analysis of apoptosis by flow cytometry.
Methods in molecular biology (Clifton, N.J.) 1998;91():217-38.
1998: Gloria Juan; Zbigniew Darzynkiewicz
Detection of cyclins in individual cells by flow and laser scanning cytometry.
Methods in molecular biology (Clifton, N.J.) 1998;91():67-75.
1997: Elzbieta Bedner; P Burfeind; Wojciech Gorczyca; Myron R Melamed; Zbigniew Darzynkiewicz
Laser scanning cytometry distinguishes lymphocytes, monocytes, and granulocytes by differences in their chromatin structure.
Cytometry 1997;29(3):191-6.
1997: BL Sailer; Joseph G Valdez; John A Steinkamp; Zbigniew Darzynkiewicz; Harry A Crissman
Monitoring uptake of ellipticine and its fluorescence lifetime in relation to the cell cycle phase by flow cytometry.
Experimental cell research 1997;236(1):259-67.
1997: S R Haider; Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz
Immunoseparation and immunodetection of nucleic acids labeled with halogenated nucleotides.
Experimental cell research 1997;234(2):498-506.
1997: Wojciech Gorczyca; V Sarode; Gloria Juan; Myron R Melamed; Zbigniew Darzynkiewicz
Laser scanning cytometric analysis of cyclin B1 in primary human malignancies.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1997;10(5):457-62.
1997: R Vibhakar; Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz; L R Finger
Activation-induced expression of human programmed death-1 gene in T-lymphocytes.
Experimental cell research 1997;232(1):25-8.
1997: Gloria Juan; X Li; Zbigniew Darzynkiewicz
Correlation between DNA replication and expression of cyclins A and B1 in individual MOLT-4 cells.
Cancer research 1997;57(5):803-7.
1997: H Dorota Halicka; Karen Seiter; Eric J Feldman; Frank Traganos; Abraham Mittelman; T Ahmed; Zbigniew Darzynkiewicz
Cell cycle specificity of apoptosis during treatment of leukaemias.
Apoptosis : an international journal on programmed cell death 1997;2(1):25-39.
1997: Wojciech Gorczyca; Zbigniew Darzynkiewicz; Myron R Melamed
Laser scanning cytometry in pathology of solid tumors. A review.
Acta cytologica 1997;41(1):98-108.
1997: Zbigniew Darzynkiewicz; Gloria Juan; Xuguang Li; Wojciech Gorczyca; T Murakami; Frank Traganos
Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis).
Cytometry 1997;27(1):1-20.
1997: Karen Seiter; Eric J Feldman; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz; DE Lake; Tauseef Ahmed
Phase I clinical and laboratory evaluation of topotecan and cytarabine in patients with acute leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(1):44-51.
1996: Frank Traganos; Karen Seiter; E Feldman; H Dorota Halicka; Zbigniew Darzynkiewicz
Induction of apoptosis by camptothecin and topotecan.
Annals of the New York Academy of Sciences 1996;803():101-10.
1996: Zbigniew Darzynkiewicz; S Bruno; G Del Bino; Frank Traganos
The cell cycle effects of camptothecin.
Annals of the New York Academy of Sciences 1996;803():93-100.
1996: Wojciech Gorczyca; Myron R Melamed; Zbigniew Darzynkiewicz
Laser scanning cytometer (LSC) analysis of fraction of labelled mitoses (FLM).
Cell proliferation 1996;29(10):539-47.
1996: Gloria Juan; W Pan; Zbigniew Darzynkiewicz
DNA segments sensitive to single-strand-specific nucleases are present in chromatin of mitotic cells.
Experimental cell research 1996;227(2):197-202.
1996: Zbigniew Darzynkiewicz; J Gong; Gloria Juan; Barbara Ardelt; Frank Traganos
Cytometry of cyclin proteins.
Cytometry 1996;25(1):1-13.
1996: Gloria Juan; J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Unscheduled expression of cyclins D1 and D3 in human tumour cell lines.
Cell proliferation 1996;29(5):259-66.
1996: S Hara; H Dorota Halicka; S Bruno; J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Effect of protease inhibitors on early events of apoptosis.
Experimental cell research 1996;223(2):372-84.
1996: Xuguang Li; Myron R Melamed; Zbigniew Darzynkiewicz
Detection of apoptosis and DNA replication by differential labeling of DNA strand breaks with fluorochromes of different color.
Experimental cell research 1996;222(1):28-37.
1995: Tomasz Skorski; Margaret Nieborowska-Skorska; K Campbell; Renato V Iozzo; G Zon; Zbigniew Darzynkiewicz; Bruno Calabretta
Leukemia treatment in severe combined immunodeficiency mice by antisense oligodeoxynucleotides targeting cooperating oncogenes.
The Journal of experimental medicine 1995;182(6):1645-53.
1995: Ze'ev Ronai; J K Tillotson; F Traganos; Zbigniew Darzynkiewicz; C C Conaway; P Upadhyaya; Karam El-Bayoumy
Effects of organic and inorganic selenium compounds on rat mammary tumor cells.
International journal of cancer. Journal international du cancer 1995;63(3):428-34.
1995: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Growth imbalance and altered expression of cyclins B1, A, E, and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1485-93.
1995: Xuguang Li; Zbigniew Darzynkiewicz
Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation.
Cell proliferation 1995;28(11):571-9.
1995: Karen Seiter; Eric J Feldman; Frank Traganos; Xuguang Li; H Dorota Halicka; Zbigniew Darzynkiewicz; C A Lederman; M B Romero; Tauseef Ahmed
Evaluation of in vivo induction of apoptosis in patients with acute leukemia treated on a phase I study of paclitaxel.
Leukemia 1995;9(11):1961-6.
1995: Xuguang Li; W M James; Frank Traganos; Zbigniew Darzynkiewicz
Application of biotin, digoxigenin or fluorescein conjugated deoxynucleotides to label DNA strand breaks for analysis of cell proliferation and apoptosis using flow cytometry.
Biotechnic & histochemistry : official publication of the Biological Stain Commission 1995;70(5):234-42.
1995: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Discrimination of G2 and mitotic cells by flow cytometry based on different expression of cyclins A and B1.
Experimental cell research 1995;220(1):226-31.
1995: U Bhatia; K Danishefsky; Frank Traganos; Zbigniew Darzynkiewicz
Induction of apoptosis and cell cycle-specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):873-80.
1995: U Bhatia; Frank Traganos; Zbigniew Darzynkiewicz
Induction of cell differentiation potentiates apoptosis triggered by prior exposure to DNA-damaging drugs.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(8):937-44.
1995: D Venturelli; Robert Martinez; P Melotti; Ida Casella; Cesare Peschle; C Cucco; G Spampinato; Zbigniew Darzynkiewicz; Bruno Calabretta
Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7435-9.
1995: T Murakami; Xuguang Li; J Gong; U Bhatia; Frank Traganos; Zbigniew Darzynkiewicz
Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity.
Cancer research 1995;55(14):3093-8.
1995: Zbigniew Darzynkiewicz
Apoptosis in antitumor strategies: modulation of cell cycle or differentiation.
Journal of cellular biochemistry 1995;58(2):151-9.
1995: Xuguang Li; Frank Traganos; Myron R Melamed; Zbigniew Darzynkiewicz
Single-step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides: detection of apoptosis and bromodeoxyuridine incorporation.
Cytometry 1995;20(2):172-80.
1995: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Threshold expression of cyclin E but not D type cyclins characterizes normal and tumour cells entering S phase.
Cell proliferation 1995;28(6):337-46.
1995: L Qiao; Wojciech Gorczyca; J G Pizzolo; Myron R Melamed; Zbigniew Darzynkiewicz
Flow cytometric characterization of proliferation-associated nuclear antigen (p105) during the cell cycle in normal lymphocytes and promyelocytic leukemia cells (HL-60).
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1995;17(3):183-8.
1995: J Gong; U Bhatia; Frank Traganos; Zbigniew Darzynkiewicz
Expression of cyclins A, D2 and D3 in individual normal mitogen stimulated lymphocytes and in MOLT-4 leukemic cells analyzed by multiparameter flow cytometry.
Leukemia 1995;9(5):893-9.
1995: H Dorota Halicka; Barbara Ardelt; Xuguang Li; M M Melamed; Zbigniew Darzynkiewicz
2-Deoxy-D-glucose enhances sensitivity of human histiocytic lymphoma U937 cells to apoptosis induced by tumor necrosis factor.
Cancer research 1995;55(2):444-9.
1994: Xuguang Li; Frank Traganos; Zbigniew Darzynkiewicz
Simultaneous analysis of DNA replication and apoptosis during treatment of HL-60 cells with camptothecin and hyperthermia and mitogen stimulation of human lymphocytes.
Cancer research 1994;54(16):4289-93.
1994: J Gong; Barbara Ardelt; Frank Traganos; Zbigniew Darzynkiewicz
Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines.
Cancer research 1994;54(16):4285-8.
1994: zhi-qin wang; A Dudhane; Thorsten W Orlikowsky; K Clarke; X Li; Zbigniew Darzynkiewicz; Michael K Hoffmann
CD4 engagement induces Fas antigen-dependent apoptosis of T cells in vivo.
European journal of immunology 1994;24(7):1549-52.
1994: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction points.
Cancer research 1994;54(12):3136-9.
1994: X Li; R Patel; M R Melamed; Zbigniew Darzynkiewicz
The cell cycle effects and induction of apoptosis by 5-bromouridine in cultures of human leukaemic MOLT-4 and HL-60 cell lines and mitogen-stimulated normal lymphocytes.
Cell proliferation 1994;27(6):307-19.
1994: R S Black; L A DeGiorgio; K F Sheu; Zbigniew Darzynkiewicz; J T Duffy; John P Blass
Expression of neuronal proteins in cells from normal adult rat brain propagated in serial culture.
Journal of neurochemistry 1994;62(6):2132-40.
1994: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry.
Analytical biochemistry 1994;218(2):314-9.
1994: E Garcia-Valenzuela; W Gorczyca; Zbigniew Darzynkiewicz; S C Sharma
Apoptosis in adult retinal ganglion cells after axotomy.
Journal of neurobiology 1994;25(4):431-8.
1994: M A Hotz; J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes.
Cytometry 1994;15(3):237-44.
1994: Frank Traganos; J Gong; Barbara Ardelt; Zbigniew Darzynkiewicz
Effect of staurosporine on MOLT-4 cell progression through G2 and on cytokinesis.
Journal of cellular physiology 1994;158(3):535-44.
1994: Jan Kajstura; Xiaoping Zhang; K Reiss; E Szoke; P Li; Costanza Lagrasta; W Cheng; Zbigniew Darzynkiewicz; Giorgio Olivetti; Piero Anversa
Myocyte cellular hyperplasia and myocyte cellular hypertrophy contribute to chronic ventricular remodeling in coronary artery narrowing-induced cardiomyopathy in rats.
Circulation research 1994;74(3):383-400.
1994: Wojciech Gorczyca; T Tuziak; A Kram; Myron R Melamed; Zbigniew Darzynkiewicz
Detection of apoptosis-associated DNA strand breaks in fine-needle aspiration biopsies by in situ end labeling of fragmented DNA.
Cytometry 1994;15(2):169-75.
1994: John P Blass; William R Markesbery; L W Ko; L DeGiorgio; K F Sheu; Zbigniew Darzynkiewicz
Presence of neuronal proteins in serially cultured cells from autopsy human brain.
Journal of the neurological sciences 1994;121(2):132-8.
1994: G Del Bino; X Li; F Traganos; Zbigniew Darzynkiewicz
Altered susceptibility of differentiating HL-60 cells to apoptosis induced by antitumor drugs.
Leukemia 1994;8(2):281-8.
1994: X Li; J Gong; E Feldman; Karen Seiter; Frank Traganos; Zbigniew Darzynkiewicz
Apoptotic cell death during treatment of leukemias.
Leukemia & lymphoma 1994;13 Suppl 1():65-70.
1994: Zbigniew Darzynkiewicz; J Gong; Frank Traganos
Analysis of DNA content and cyclin protein expression in studies of DNA ploidy, growth fraction, lymphocyte stimulation, and the cell cycle.
Methods in cell biology 1994;41():421-35.
1994: Zbigniew Darzynkiewicz; X Li; J Gong
Assays of cell viability: discrimination of cells dying by apoptosis.
Methods in cell biology 1994;41():15-38.
1994: Zbigniew Darzynkiewicz
Acid-induced denaturation of DNA in situ as a probe of chromatin structure.
Methods in cell biology 1994;41():527-41.
1994: Zbigniew Darzynkiewicz
Simultaneous analysis of cellular RNA and DNA content.
Methods in cell biology 1994;41():401-20.
1994: Frank Traganos; Zbigniew Darzynkiewicz
Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations.
Methods in cell biology 1994;41():185-94.
1994: P Lassota; Zygmunt Kazimierczuk; Zbigniew Darzynkiewicz
Apoptotic death of lymphocytes upon treatment with 2-chloro-2'-deoxyadenosine (2-CdA).
Archivum immunologiae et therapiae experimentalis 1994;42(1):17-23.
1993: J Gong; Xuguang Li; Zbigniew Darzynkiewicz
Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin.
Journal of cellular physiology 1993;157(2):263-70.
1993: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Simultaneous analysis of cell cycle kinetics at two different DNA ploidy levels based on DNA content and cyclin B measurements.
Cancer research 1993;53(21):5096-9.
1993: Frank Traganos; J Kapuscinski; J Gong; Barbara Ardelt; R J Darzynkiewicz; Zbigniew Darzynkiewicz
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells.
Cancer research 1993;53(19):4613-8.
1993: Annabel Strife; A Perez; C Lambek; David Wisniewski; S Bruno; Zbigniew Darzynkiewicz; Bayard Clarkson
Differences in the composition and in the efficiency of red cell production of normal and CML erythroid progenitor populations are highlighted by response to human c-kit ligand.
Leukemia research 1993;17(9):799-807.
1993: Wojciech Gorczyca; Frank Traganos; H Jesionowska; Zbigniew Darzynkiewicz
Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells.
Experimental cell research 1993;207(1):202-5.
1993: Wojciech Gorczyca; J Gong; Barbara Ardelt; Frank Traganos; Zbigniew Darzynkiewicz
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents.
Cancer research 1993;53(13):3186-92.
1993: J M Capasso; S Bruno; P Li; X Zhang; Zbigniew Darzynkiewicz; Piero Anversa
Myocyte DNA synthesis with aging: correlation with ventricular loading in rats.
Journal of cellular physiology 1993;155(3):635-48.
1993: Wojciech Gorczyca; K Bigman; A Mittelman; T Ahmed; J Gong; Myron R Melamed; Zbigniew Darzynkiewicz
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.
Leukemia 1993;7(5):659-70.
1993: Wojciech Gorczyca; J Gong; Zbigniew Darzynkiewicz
Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.
Cancer research 1993;53(8):1945-51.
1993: Wojciech Gorczyca; Myron R Melamed; Zbigniew Darzynkiewicz
Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay.
Toxicology letters 1993;67(1-3):249-58.
1993: Zbigniew Darzynkiewicz; Wojciech Gorczyca; P Lassota; Frank Traganos
Altered sensitivity of DNA in situ to denaturation in apoptotic cells.
Annals of the New York Academy of Sciences 1993;677():334-40.
1993: Annabel Strife; A Perez; C Lambek; David Wisniewski; S Bruno; Zbigniew Darzynkiewicz; Bayard Clarkson
Characterization of lineage-negative blast subpopulations derived from normal and chronic myelogenous leukemia bone marrows and determination of their responsiveness to human c-kit ligand.
Cancer research 1993;53(2):401-9.
1993: W Gorczyca; M R Melamed; Zbigniew Darzynkiewicz
[Programmed death of cells (apoptosis)].
Patologia polska 1993;44(3):113-9.
1993: Wojciech Gorczyca; A Kram; T Tuziak; Zbigniew Darzynkiewicz; Myron R Melamed
Proliferating cell nuclear antigen in archival surgical specimens of malignant lymphoma and metastatic carcinoma: immunohistochemical and flow cytometric analysis.
Patologia polska 1993;44(3):121-8.
1992: J M Capasso; S Bruno; W Cheng; P Li; R Rodgers; Zbigniew Darzynkiewicz; Piero Anversa
Ventricular loading is coupled with DNA synthesis in adult cardiac myocytes after acute and chronic myocardial infarction in rats.
Circulation research 1992;71(6):1379-89.
1992: Frank Traganos; Barbara Ardelt; N Halko; S Bruno; Zbigniew Darzynkiewicz
Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells.
Cancer research 1992;52(22):6200-8.
1992: G Del Bino; S Bruno; P N Yi; Zbigniew Darzynkiewicz
Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation.
Cell proliferation 1992;25(6):537-48.
1992: S Bruno; G Del Bino; P Lassota; W Giaretti; Zbigniew Darzynkiewicz
Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.
Leukemia 1992;6(11):1113-20.
1992: Stanislaw M Mikulski; A Viera; Zbigniew Darzynkiewicz; Kuslima Shogen
Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines.
British journal of cancer 1992;66(2):304-10.
1992: R S Black; M M Bouvier; K F Sheu; Zbigniew Darzynkiewicz; John P Blass
Presence of typical neuronal markers in serially cultured cells from adult human brain.
Journal of the neurological sciences 1992;111(1):104-12.
1992: M A Hotz; Frank Traganos; Zbigniew Darzynkiewicz
Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation.
Experimental cell research 1992;201(1):184-91.
1992: Wojciech Gorczyca; S Bruno; Myron R Melamed; Zbigniew Darzynkiewicz
Cell cycle-related expression of p120 nucleolar antigen in normal human lymphocytes and in cells of HL-60 and MOLT-4 leukemic lines: effects of methotrexate, camptothecin, and teniposide.
Cancer research 1992;52(12):3491-4.
1992: S Bruno; W Giaretti; Zbigniew Darzynkiewicz
Effect of camptothecin on mitogenic stimulation of human lymphocytes: involvement of DNA topoisomerase I in cell transition from G0 to G1 phase of the cell cycle and in DNA replication.
Journal of cellular physiology 1992;151(3):478-86.
1992: Coralia I Rivas; David Wisniewski; Annabel Strife; A Perez; C Lambek; S Bruno; Zbigniew Darzynkiewicz; Bayard Clarkson
Constitutive expression of p53 protein in enriched normal human marrow blast cell populations.
Blood 1992;79(8):1982-6.
1992: M A Hotz; G Del Bino; P Lassota; Frank Traganos; Zbigniew Darzynkiewicz
Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells.
Cancer research 1992;52(6):1530-5.
1992: S Bruno; Barbara Ardelt; J S Skierski; Frank Traganos; Zbigniew Darzynkiewicz
Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes.
Cancer research 1992;52(2):470-3.
1992: S Bruno; Zbigniew Darzynkiewicz
Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells.
Cell proliferation 1992;25(1):31-40.
1992: S Bruno; P Lassota; W Giaretti; Zbigniew Darzynkiewicz
Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases.
Oncology research 1992;4(1):29-35.
1992: S Bruno; Wojciech Gorczyca; Zbigniew Darzynkiewicz
Effect of ionic strength in immunocytochemical detection of the proliferation associated nuclear antigens p120, PCNA, and the protein reacting with Ki-67 antibody.
Cytometry 1992;13(5):496-501.
1992: Zbigniew Darzynkiewicz; S Bruno; G Del Bino; Wojciech Gorczyca; M A Hotz; P Lassota; Frank Traganos
Features of apoptotic cells measured by flow cytometry.
Cytometry 1992;13(8):795-808.
1992: Andrzej Myc; F Traganos; J Lara; M R Melamed; Zbigniew Darzynkiewicz
DNA stainability in aneuploid breast tumors: comparison of four DNA fluorochromes differing in binding properties.
Cytometry 1992;13(4):389-94.
1991: Annabel Strife; C Lambek; A Perez; Zbigniew Darzynkiewicz; J Skierski; S Gulati; J D Haley; Peter ten Dijke; K K Iwata; Bayard Clarkson
The effects of transforming growth factor beta 3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood.
Cancer research 1991;51(18):4828-36.
1991: S Bruno; H A Crissman; K D Bauer; Zbigniew Darzynkiewicz
Changes in cell nuclei during S phase: progressive chromatin condensation and altered expression of the proliferation-associated nuclear proteins Ki-67, cyclin (PCNA), p105, and p34.
Experimental cell research 1991;196(1):99-106.
1991: G Del Bino; J S Skierski; Zbigniew Darzynkiewicz
The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells.
Experimental cell research 1991;195(2):485-91.
1991: Frank Traganos; J Kapuscinski; Zbigniew Darzynkiewicz
Caffeine modulates the effects of DNA-intercalating drugs in vitro: a flow cytometric and spectrophotometric analysis of caffeine interaction with novantrone, doxorubicin, ellipticine, and the doxorubicin analogue AD198.
Cancer research 1991;51(14):3682-9.
1991: Andrzej Myc; P DeAngelis; P Lassota; M R Melamed; Zbigniew Darzynkiewicz
Effect of swainsonine on interleukin-2 alpha chain receptor expression and proliferation of human lymphocytes.
Clinical and experimental immunology 1991;84(3):406-10.
1991: Frank Traganos; B Kaminska-Eddy; Zbigniew Darzynkiewicz
Caffeine reverses the cytotoxic and cell kinetic effects of Novantrone (mitoxantrone).
Cell proliferation 1991;24(3):305-19.
1991: M Jakóbisiak; S Bruno; J S Skierski; Zbigniew Darzynkiewicz
Cell cycle-specific effects of lovastatin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3628-32.
1991: P Lassota; M R Melamed; Zbigniew Darzynkiewicz
Release of specific proteins from nuclei of HL-60 and MOLT-4 cells by antitumor drugs having affinity to nucleic acids.
Biochemical pharmacology 1991;41(6-7):1055-65.
1991: G Del Bino; P Lassota; Zbigniew Darzynkiewicz
The S-phase cytotoxicity of camptothecin.
Experimental cell research 1991;193(1):27-35.
1991: G Del Bino; Zbigniew Darzynkiewicz
Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.
Cancer research 1991;51(4):1165-9.
1991: Andrzej Myc; P DeAngelis; M Kimmel; M R Melamed; Zbigniew Darzynkiewicz
Retention of the mitochondrial probe rhodamine 123 in normal lymphocytes and leukemic cells in relation to the cell cycle.
Experimental cell research 1991;192(1):198-202.
1990: P R Bretton; Zbigniew Darzynkiewicz; E Henry; M Kimmel; W R Fair; M R Melamed
DNA in situ sensitivity to denaturation in bladder cancer and its correlation with tumor stage.
Cancer research 1990;50(24):7912-4.
1990: G Del Bino; J S Skierski; Zbigniew Darzynkiewicz
Diverse effects of camptothecin, an inhibitor of topoisomerase I, on the cell cycle of lymphocytic (L1210, MOLT-4) and myelogenous (HL-60, KG1) leukemic cells.
Cancer research 1990;50(18):5746-50.
1990: D Evenson; Zbigniew Darzynkiewicz
Acridine orange-induced precipitation of mouse testicular sperm cell DNA reveals new patterns of chromatin structure.
Experimental cell research 1990;187(2):328-34.
1990: J Kapuscinski; Zbigniew Darzynkiewicz
Spectral properties of fluorochromes used in flow cytometry.
Methods in cell biology 1990;33():655-69.
1990: Zbigniew Darzynkiewicz
Acid-induced denaturation of DNA in situ as a probe of chromatin structure.
Methods in cell biology 1990;33():337-52.
1990: Harry A Crissman; Zbigniew Darzynkiewicz; John A Steinkamp; R A Tobey
Simultaneous fluorescent labeling of DNA, RNA, and protein.
Methods in cell biology 1990;33():305-14.
1990: Zbigniew Darzynkiewicz
Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange.
Methods in cell biology 1990;33():285-98.
1990: J E Kunicka; Andrzej Myc; M R Melamed; Zbigniew Darzynkiewicz
Caffeine increases sensitivity of DNA to denaturation in chromatin of L1210 cells.
Cell and tissue kinetics 1990;23(1):31-9.
1989: D Bories; M C Raynal; D H Solomon; Zbigniew Darzynkiewicz; Y E Cayre
Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.
Cell 1989;59(6):959-68.
1989: J E Kunicka; W Olszewski; Paul Peter Rosen; M Kimmel; M R Melamed; Zbigniew Darzynkiewicz
DNA in situ sensitivity to denaturation as a marker of human breast tumors.
Cancer research 1989;49(22):6347-51.
1989: Zbigniew Darzynkiewicz; S P Carter; J Kapuscinski; K A Watanabe
Effect of derivatives of chrysophanol, a new type of potential antitumor agents of anthraquinone family, on growth and cell cycle of L1210 leukemic cells.
Cancer letters 1989;46(3):181-7.
1989: M Koyama; K Takahashi; Ting-Chao Chou; Zbigniew Darzynkiewicz; J Kapuscinski; T R Kelly; KA Watanabe
Intercalating agents with covalent bond forming capability. A novel type of potential anticancer agents. 2. Derivatives of chrysophanol and emodin.
Journal of medicinal chemistry 1989;32(7):1594-9.
1989: J Bartkowiak; J Kapuscinski; M R Melamed; Zbigniew Darzynkiewicz
Selective displacement of nuclear proteins by antitumor drugs having affinity for nucleic acids.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):5151-4.
1989: F Traganos; C Bueti; J Kapuscinski; Zbigniew Darzynkiewicz
The antitumor intercalating drug ditercalinium binds preferentially to RNA in Friend erythroleukemia cells.
Leukemia 1989;3(7):522-9.
1989: Andrzej Myc; J E Kunicka; M R Melamed; Zbigniew Darzynkiewicz
Effect of swainsonine on stimulation and cell cycle progression of human lymphocytes.
Cancer research 1989;49(11):2879-83.
1989: Lisa Staiano-Coico; Zbigniew Darzynkiewicz; C K McMahon
Cultured human keratinocytes: discrimination of different cell cycle compartments based upon measurement of nuclear RNA or total cellular RNA content.
Cell and tissue kinetics 1989;22(3):235-43.
1989: Zbigniew Darzynkiewicz; S P Carter
Thermal stability of nucleosomes studied in situ by flow cytometry: effect of ionic strength and n-butyrate.
Experimental cell research 1989;180(2):551-6.
1989: B Czerniak; Zbigniew Darzynkiewicz; F Herz; R P Wersto; Leopold G Koss
Flow cytometry in clinical oncology: cell cycle and DNA ploidy in assessing tumor behavior.
Materia medica Polona. Polish journal of medicine and pharmacy 1989;21(1):3-9.
1988: Zbigniew Darzynkiewicz
Flow cytometry in cytopathology. Overview and perspectives.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1988;10(6):459-61.
1988: Zbigniew Darzynkiewicz; F Traganos
Unstainable DNA in cell nuclei. Comparison of ten different fluorochromes.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1988;10(6):462-6.
1988: Zbigniew Darzynkiewicz
Cellular RNA content, a feature correlated with cell kinetics and tumor prognosis.
Leukemia 1988;2(12):777-87.
1988: F Traganos; H A Crissman; Zbigniew Darzynkiewicz
Staining with pyronin Y detects changes in conformation of RNA during mitosis and hyperthermia of CHO cells.
Experimental cell research 1988;179(2):535-44.
1988: J Kapuscinski; F Traganos; Zbigniew Darzynkiewicz
Interactions of antitumor drug ditercalinium with nucleic acids in solutions and in situ.
Cancer letters 1988;42(3):185-91.
1988: Zbigniew Darzynkiewicz; S P Carter; Stanislaw M Mikulski; Wojciech Ardelt; Kuslima Shogen
Cytostatic and cytotoxic effects of Pannon (P-30 Protein), a novel anticancer agent.
Cell and tissue kinetics 1988;21(3):169-82.
1988: Zbigniew Darzynkiewicz; S P Carter
Photosensitizing effects of the tricyclic heteroaromatic cationic dyes pyronin Y and toluidine blue O (tolonium chloride).
Cancer research 1988;48(5):1295-9.
1988: A J Walle; G Y Wong; M Suthanthiran; A L Rubin; K H Stenzel; Zbigniew Darzynkiewicz
Altered nucleic acid contents of mononuclear cells in blood of renal allograft recipients.
Cytometry 1988;9(2):177-82.
1988: Zbigniew Darzynkiewicz; J Kapuscinski
Condensation of DNA in situ in metaphase chromosomes induced by intercalating ligands and its relationship to chromosome banding.
Cytometry 1988;9(1):7-18.
1987: Y Cayre; M C Raynal; Zbigniew Darzynkiewicz; M H Dorner
Model for intermediate steps in monocytic differentiation: c-myc, c-fms, and ferritin as markers.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7619-23.
1987: F Traganos; Marek Kimmel; C Bueti; Zbigniew Darzynkiewicz
Effects of inhibition of RNA or protein synthesis on CHO cell cycle progression.
Journal of cellular physiology 1987;133(2):277-87.
1987: Zbigniew Darzynkiewicz; F Traganos; S P Carter; P J Higgins
In situ factors affecting stability of the DNA helix in interphase nuclei and metaphase chromosomes.
Experimental cell research 1987;172(1):168-79.
1987: J E Kunicka; Zbigniew Darzynkiewicz; M R Melamed
DNA in situ sensitivity to denaturation: a new parameter for flow cytometry of normal human colonic epithelium and colon carcinoma.
Cancer research 1987;47(15):3942-7.
1987: J Kapuscinski; Zbigniew Darzynkiewicz
Interactions of acridine orange with double stranded nucleic acids. Spectral and affinity studies.
Journal of biomolecular structure & dynamics 1987;5(1):127-43.
1987: F Traganos; C Bueti; M R Melamed; Zbigniew Darzynkiewicz
Cytokinetic effects of bifunctional antitumor intercalator ditercalinium on Friend erythroleukemia cells.
Leukemia 1987;1(5):411-6.
1987: R A Tobey; Harry A Crissman; M E Wilder; F Traganos; Zbigniew Darzynkiewicz
Sensitivity to X-irradiation in relation to cell size of CHO cells synchronized in early G1.
Cell and tissue kinetics 1987;20(3):363-6.
1987: J Kapuscinski; Zbigniew Darzynkiewicz
Interactions of pyronin Y(G) with nucleic acids.
Cytometry 1987;8(2):129-37.
1987: Zbigniew Darzynkiewicz; S P Carter; Lloyd J Old
Effect of recombinant tumor necrosis factor on HL-60 cells: cell-cycle specificity and synergism with actinomycin D.
Journal of cellular physiology 1987;130(3):328-35.
1987: Zbigniew Darzynkiewicz; J Kapuscinski; F Traganos; H A Crissman
Application of pyronin Y(G) in cytochemistry of nucleic acids.
Cytometry 1987;8(2):138-45.
1987: A J Walle; M Suthanthiran; Zbigniew Darzynkiewicz; A L Rubin; K H Stenzel
Cell cycle analysis of activated mononuclear blood cells of renal allograft recipients.
Transplantation proceedings 1987;19(1 Pt 3):2183-4.
1987: F Traganos; C Bueti; Zbigniew Darzynkiewicz; M R Melamed
Effects of a new amsacrine derivative, N-5-dimethyl-9-(2-methoxy-4-methylsulfonylamino)phenylamino-4- acridinecarboxamide, on cultured mammalian cells.
Cancer research 1987;47(2):424-32.
1986: Zbigniew Darzynkiewicz; J Kapuscinski; S P Carter; F A Schmid; M R Melamed
Cytostatic and cytotoxic properties of pyronin Y: relation to mitochondrial localization of the dye and its interaction with RNA.
Cancer research 1986;46(11):5760-6.
1986: J Kapuscinski; Zbigniew Darzynkiewicz
Relationship between the pharmacological activity of antitumor drugs Ametantrone and mitoxantrone (Novatrone) and their ability to condense nucleic acids.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6302-6.
1986: M Kimmel; Zbigniew Darzynkiewicz; L Staiano-Coico
Stathmokinetic analysis of human epidermal cells in vitro.
Cell and tissue kinetics 1986;19(3):289-304.
1986: M R Melamed; Warren E Enker; P Banner; A J Janov; G Kessler; Zbigniew Darzynkiewicz
Flow cytometry of colorectal carcinoma with three-year follow-up.
Diseases of the colon and rectum 1986;29(3):184-6.
1986: L Staiano-Coico; P J Higgins; Zbigniew Darzynkiewicz; M Kimmel; A B Gottlieb; I Pagan-Charry; M R Madden; J L Finkelstein; J M Hefton
Human keratinocyte culture. Identification and staging of epidermal cell subpopulations.
The Journal of clinical investigation 1986;77(2):396-404.
1986: Zbigniew Darzynkiewicz; L Staiano-Coico; J E Kunicka; A B DeLeo; Lloyd J Old
p53 content in relation to cell growth and proliferation in murine L1210 leukemia and normal lymphocytes.
Leukemia research 1986;10(12):1383-9.
1986: Zbigniew Darzynkiewicz; F Traganos; L Staiano-Coico
Cell and nuclear growth during G1: kinetic and clinical implications.
Annals of the New York Academy of Sciences 1986;468():45-54.
1986: D Evenson; Zbigniew Darzynkiewicz; Lorna K Jost; F Janca; B Ballachey
Changes in accessibility of DNA to various fluorochromes during spermatogenesis.
Cytometry 1986;7(1):45-53.
1985: J Kapuscinski; Zbigniew Darzynkiewicz
Interactions of antitumor agents Ametantrone and Mitoxantrone (Novatrone) with double-stranded DNA.
Biochemical pharmacology 1985;34(24):4203-13.
1985: L Staiano-Coico; B D Stollar; Zbigniew Darzynkiewicz; R Dutkowski; Marc E Weksler
Binding of anti-Z-DNA antibodies in quiescent and activated lymphocytes: relationship to cell cycle progression and chromatin changes.
Molecular and cellular biology 1985;5(11):3270-3.
1985: R Moran; Zbigniew Darzynkiewicz; L Staiano-Coico; M R Melamed
Detection of 5-bromodeoxyuridine (BrdUrd) incorporation by monoclonal antibodies: role of the DNA denaturation step.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(8):821-7.
1985: J Melamed; Zbigniew Darzynkiewicz
RNA content and chromatin structure of CHO cells arrested in metaphase by colcemid.
Cytometry 1985;6(4):381-5.
1985: Harry A Crissman; Zbigniew Darzynkiewicz; R A Tobey; John A Steinkamp
Normal and perturbed Chinese hamster ovary cells: correlation of DNA, RNA, and protein content by flow cytometry.
The Journal of cell biology 1985;101(1):141-7.
1985: H A Crissman; Zbigniew Darzynkiewicz; R A Tobey; John A Steinkamp
Correlated measurements of DNA, RNA, and protein in individual cells by flow cytometry.
Science (New York, N.Y.) 1985;228(4705):1321-4.
1985: L Staiano-Coico; J Huffman; R Wolf; C M Pinsky; Harry W Herr; W F Whitmore; H F Oettgen; Zbigniew Darzynkiewicz; M R Melamed
Monitoring intravesical bacillus Calmette-Guerin treatment of bladder carcinoma with flow cytometry.
The Journal of urology 1985;133(5):786-8.
1985: Zbigniew Darzynkiewicz; F Traganos; J Kapuscinski; M R Melamed
Denaturation and condensation of DNA in situ induced by acridine orange in relation to chromatin changes during growth and differentiation of Friend erythroleukemia cells.
Cytometry 1985;6(3):195-207.
1985: D P Evenson; J Lee; Zbigniew Darzynkiewicz; M R Melamed
Rhodamine 123 alters the mitochondrial ultrastructure of cultured L1210 cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(4):353-9.
1984: J Kapuscinski; Zbigniew Darzynkiewicz
Condensation of nucleic acids by intercalating aromatic cations.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7368-72.
1984: Zbigniew Darzynkiewicz; S Carter; M Kimmel
Effects of [3H]UdR on the cell-cycle progression of L1210 cells.
Cell and tissue kinetics 1984;17(6):641-55.
1984: Marek Kimmel; Zbigniew Darzynkiewicz; O Arino; F Traganos
Analysis of a cell cycle model based on unequal division of metabolic constituents to daughter cells during cytokinesis.
Journal of theoretical biology 1984;110(4):637-64.
1984: B Czerniak; Zbigniew Darzynkiewicz; L Staiano-Coico; F Herz; Leopold G Koss
Expression of Ca antigen in relation to cell cycle in cultured human tumor cells.
Cancer research 1984;44(10):4342-6.
1984: F Traganos; P J Higgins; C Bueti; Zbigniew Darzynkiewicz; M R Melamed
Effects of retinoic acid versus dimethyl sulfoxide on Friend erythroleukemia cell growth. II. Induction of quiescent, nonproliferating cells.
Journal of the National Cancer Institute 1984;73(1):205-18.
1984: F Traganos; C Bueti; Zbigniew Darzynkiewicz; M R Melamed
Effects of retinoic acid versus dimethyl sulfoxide on Friend erythroleukemia cell growth. I. Cell proliferation, RNA content, and protein content.
Journal of the National Cancer Institute 1984;73(1):193-204.
1984: Zbigniew Darzynkiewicz; F Traganos; J Kapuscinski; L Staiano-Coico; M R Melamed
Accessibility of DNA in situ to various fluorochromes: relationship to chromatin changes during erythroid differentiation of Friend leukemia cells.
Cytometry 1984;5(4):355-63.
1984: J Kapuscinski; Zbigniew Darzynkiewicz
Denaturation of nucleic acids induced by intercalating agents. Biochemical and biophysical properties of acridine orange-DNA complexes.
Journal of biomolecular structure & dynamics 1984;1(6):1485-99.
1984: Zbigniew Darzynkiewicz; S Carter
Compound 48/80 impairs cytokinesis in murine leukemic cells.
Journal of cellular physiology 1984;119(1):1-6.
1984: P J Higgins; M Piwnicka; Zbigniew Darzynkiewicz; M R Melamed
Multiparameter flow cytometric analysis of hepatic nuclear RNA and DNA of normal and hepatotoxin-treated mice.
The American journal of pathology 1984;115(1):31-5.
1984: L Staiano-Coico; Zbigniew Darzynkiewicz; M R Melamed; Marc E Weksler
Immunological studies of aging. IX. Impaired proliferation of T lymphocytes detected in elderly humans by flow cytometry.
Journal of immunology (Baltimore, Md. : 1950) 1984;132(4):1788-92.
1984: L Staiano-Coico; R Wolf; Zbigniew Darzynkiewicz; W F Whitmore; M R Melamed
RNA and DNA content of isolated nuclei from bladder irrigation specimens as measured by flow cytometry.
Analytical and quantitative cytology 1984;6(1):24-9.
1984: Zbigniew Darzynkiewicz; B Williamson; E A Carswell; Lloyd J Old
Cell cycle-specific effects of tumor necrosis factor.
Cancer research 1984;44(1):83-90.
1984: F Traganos; Zbigniew Darzynkiewicz; C Bueti; M R Melamed
Effects of a prospective antitumor agent, 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane diperchlorate, on cultured mammalian cells.
Cancer investigation 1984;2(1):1-13.
1983: J Kapuscinski; Zbigniew Darzynkiewicz; M R Melamed
Interactions of acridine orange with nucleic acids. Properties of complexes of acridine orange with single stranded ribonucleic acid.
Biochemical pharmacology 1983;32(24):3679-94.
1983: J Kapuscinski; Zbigniew Darzynkiewicz
Increased accessibility of bases in DNA upon binding of acridine orange.
Nucleic acids research 1983;11(21):7555-68.
1983: M Kimmel; F Traganos; Zbigniew Darzynkiewicz
Do all daughter cells enter the "indeterminate" ("A") state of the cell cycle? Analysis of stathmokinetic experiments on L1210 cells.
Cytometry 1983;4(3):191-201.
1983: Zbigniew Darzynkiewicz; D Evenson; J Kapuscinski; M R Melamed
Denaturation of RNA and DNA in situ induced by acridine orange.
Experimental cell research 1983;148(1):31-46.
1983: P J Higgins; Zbigniew Darzynkiewicz; M R Melamed
Secretion of albumin and alpha-foetoprotein by dimethylsulphoxide-stimulated hepatocellular carcinoma cells.
British journal of cancer 1983;48(4):485-93.
1983: L Staiano-Coico; Zbigniew Darzynkiewicz; J M Hefton; R Dutkowski; G J Darlington; Marc E Weksler
Increased sensitivity of lymphocytes from people over 65 to cell cycle arrest and chromosomal damage.
Science (New York, N.Y.) 1983;219(4590):1335-7.
1983: Zbigniew Darzynkiewicz; F Traganos; M R Melamed
Distinction between 5-bromodeoxyuridine labeled and unlabeled mitotic cells by flow cytometry.
Cytometry 1983;3(5):345-8.
1983: Milan Potmesil; M Levin; F Traganos; M Israel; Zbigniew Darzynkiewicz; V K Khetarpal; R Silber
In vivo effects of adriamycin or N-trifluoroacetyladriamycin-14-valerate on a mouse lymphoma.
European journal of cancer & clinical oncology 1983;19(1):109-22.
1983: Zbigniew Darzynkiewicz
New cell cycle compartments distinguished by multiparameter flow cytometry.
Progress in clinical and biological research 1983;132C():171-7.
1983: Zbigniew Darzynkiewicz
Molecular interactions and cellular changes during the cell cycle.
Pharmacology & therapeutics 1983;21(2):143-88.
1983: M Piwnicka; Zbigniew Darzynkiewicz; M R Melamed
RNA and DNA content of isolated cell nuclei measured by multiparameter flow cytometry.
Cytometry 1983;3(4):269-75.
1982: W Ołszewski; Zbigniew Darzynkiewicz; Paul Peter Rosen; M L Claps; M R Melamed
Flow cytometry of breast carcinoma. III. Possible altered kinetics in axillary lymph node metastases.
Analytical and quantitative cytology 1982;4(4):275-8.
1982: Zbigniew Darzynkiewicz; H Crissman; F Traganos; J Steinkamp
Cell heterogeneity during the cell cycle.
Journal of cellular physiology 1982;113(3):465-74.
1982: L Staiano-Coico; Zbigniew Darzynkiewicz; M R Melamed; M Weksler
Changes in DNA content of human blood mononuclear cells with senescence.
Cytometry 1982;3(2):79-83.
1982: W Ołszewski; Zbigniew Darzynkiewicz; M L Claps; M R Melamed
Flow cytometry of lung carcinoma: a comparison of DNA stemline and cell cycle distribution with histology.
Analytical and quantitative cytology 1982;4(2):90-8.
1982: Zbigniew Darzynkiewicz; F Traganos; L Staiano-Coico; J Kapuscinski; M R Melamed
Interaction of rhodamine 123 with living cells studied by flow cytometry.
Cancer research 1982;42(3):799-806.
1982: D P Evenson; Zbigniew Darzynkiewicz; M R Melamed
Simultaneous measurement by flow cytometry of sperm cell viability and mitochondrial membrane potential related to cell motility.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1982;30(3):279-80.
1982: F A Klein; M R Melamed; W F Whitmore; Harry W Herr; P C Sogani; Zbigniew Darzynkiewicz
Characterization of bladder papilloma by two-parameter DNA-RNA flow cytometry.
Cancer research 1982;42(3):1094-7.
1982: F Traganos; Zbigniew Darzynkiewicz; M R Melamed
The ratio of RNA to total nucleic acid content as a quantitative measure of unbalanced cell growth.
Cytometry 1982;2(4):212-8.
1982: J Kapuscinski; Zbigniew Darzynkiewicz; M R Melamed
Luminescence of the solid complexes of acridine orange with RNA.
Cytometry 1982;2(4):201-11.