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Christine Van Broeckhoven

Research Profile

Disorders

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Physiology

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Chemicals & Drugs

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Chromosomes, Human, Pair 21

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Belgium

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Publications

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Rita Cacace; Marc Cruts; Peter P De Deyn; L Dillen; Sebastiaan Engelborghs; Ilse Gijselinck; Maria Mattheijssens; Karin Peeters; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Julie van der Zee; Jasper Van Dongen; Rik Vandenberghe; Mathieu Vandenbulcke; Veerle Bäumer; Karolien Bettens; Kristel Sleegers
C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment.
L Dillen; Sebastiaan Engelborghs; Albena Jordanova; Celine Merlin; Stayko Sarafov; Ivailo Tournev; Christine Van Broeckhoven; Julie van der Zee; Tim Van Langenhove; Rik Vandenberghe; Mathieu Vandenbulcke; Patrick cras; Marc Cruts; Peter P De Deyn
Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients.
Greetje Vanhoutte; Jelle Veraart; Marleen Verhoye; Bob Asselbergh; Rafael Delgado Y Palacios; Pieter-Jan Guns; Sandra Pereson; Jan Sijbers; Christine Van Broeckhoven; Annemie Van der Linden
Diffusion kurtosis imaging to detect amyloidosis in an APP/PS1 mouse model for Alzheimer's disease.

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All Publications

2013: Rita Cacace; Marc Cruts; Peter P De Deyn; L Dillen; Sebastiaan Engelborghs; Ilse Gijselinck; Maria Mattheijssens; Karin Peeters; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Julie van der Zee; Jasper Van Dongen; Rik Vandenberghe; Mathieu Vandenbulcke; Veerle Bäumer; Karolien Bettens; Kristel Sleegers
C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment.
Neurobiology of aging 2013;34(6):1712.e1-7.
2013: L Dillen; Sebastiaan Engelborghs; Albena Jordanova; Celine Merlin; Stayko Sarafov; Ivailo Tournev; Christine Van Broeckhoven; Julie van der Zee; Tim Van Langenhove; Rik Vandenberghe; Mathieu Vandenbulcke; Patrick cras; Marc Cruts; Peter P De Deyn
Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients.
Neurobiology of aging 2013;34(6):1711.e1-5.
2013: Greetje Vanhoutte; Jelle Veraart; Marleen Verhoye; Bob Asselbergh; Rafael Delgado Y Palacios; Pieter-Jan Guns; Sandra Pereson; Jan Sijbers; Christine Van Broeckhoven; Annemie Van der Linden
Diffusion kurtosis imaging to detect amyloidosis in an APP/PS1 mouse model for Alzheimer's disease.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2013;69(4):1115-21.
2013: Bettina Schmid; Barbara Solchenberger; Katrin Strecker; Mathias Teucke; Frauke van Bebber; Christine Van Broeckhoven; Julie van der Zee; Julia Banzhaf-Strathmann; Marc Cruts; Dieter Edbauer; Stefan Eimer; Laura Hasenkamp; Jan Hegermann; Sebastian Hogl; Alexander Hruscha; Maike Kittelmann; Elisabeth Kremmer; Stefan F Lichtenthaler; Christian Haass
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(13):4986-91.
2013: Kohji Mori; Kristin Rentzsch; Bettina Schmid; Christine Van Broeckhoven; Shih-Ming Weng; Christian Haass; Elisabeth Kremmer; Hans A Kretzschmar; Stephanie May; Thomas Arzberger; Marc Cruts; Dieter Edbauer
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.
Science (New York, N.Y.) 2013;339(6125):1335-8.
2013: Niels Fockaert; Christine Van Broeckhoven; Marc Van Orshoven; Patrick cras; Philippe Demaerel; Wim Vandenberghe
Slowing of saccadic eye movements in sporadic Creutzfeldt-Jakob disease.
Movement disorders : official journal of the Movement Disorder Society 2013;28(3):291-3.
2013: Kohji Mori; Manuela Neumann; Christine Van Broeckhoven; Sonja Zilow; Thomas Arzberger; Marc Cruts; Dieter Edbauer; Ignasi Forné; Jochen Herms; Jonathan Janssens; Gernot Kleinberger; Hans A Kretzschmar; Sven Lammich; Ian R A Mackenzie; Christian Haass
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.
Acta neuropathologica 2013;125(3):413-23.
2013: Tim Van Langenhove; Rik Vandenberghe; Mathieu Vandenbulcke; Jan Versijpt; Christiana Willems; Marleen Van den Broeck; Julie van der Zee; Veerle Bäumer; Patrick cras; Marc Cruts; Jan De Bleecker; Peter P De Deyn; Peter De Jonghe; Olivier Deryck; Lubina Dillen; Sebastiaan Engelborghs; Ilse Gijselinck; Adrian Ivanoiu; Githa Maes; Jean-Jacques Martin; Maria Mattheijssens; Alex Michotte; Karin Peeters; Stéphanie Philtjens; Patrick Santens; Anne Sieben; Christine Van Broeckhoven
Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort.
JAMA neurology 2013;70(3):365-73.
2013: Gernot Kleinberger; Anja Capell; Christian Haass; Christine Van Broeckhoven
Mechanisms of granulin deficiency: lessons from cellular and animal models.
Molecular neurobiology 2013;47(1):337-60.
2013: Lies Vanden Broeck; Yoshitsugu Adachi; Stein Aerts; Patrick Callaerts; Julien Chapuis; Danielle Diaper; Pierre Dourlen; Marc Gistelinck; Frank Hirth; Gernot Kleinberger; Jean-Charles Lambert; Marina Naval-Sánchez; Christine Van Broeckhoven; Bart Dermaut
TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila.
Cell reports 2013;3(1):160-72.
2013: Sylvie Slaets; Kristel Sleegers; Jessie Theuns; Christine Van Broeckhoven; Aline Verstraeten; Evelyn De Leenheir; Nathalie Le Bastard; Jill Luyckx; Jean-Jacques Martin; Sebastiaan Engelborghs
Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies.
Journal of Alzheimer's disease : JAD 2013;35(1):137-46.
2013: Sebastiaan Engelborghs; Nathalie Le Bastard; Kristel Sleegers; Christine Van Broeckhoven; Stefan Van der Mussele; Nathalie Brouwers; Peter Paul De Deyn
Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;35(1):67-73.
2013: Karolien Bettens; Kristel Sleegers; Christine Van Broeckhoven
Genetic insights in Alzheimer's disease.
Lancet neurology 2013;12(1):92-104.
2013: Nathalie Le Bastard; Jean-Jacques Martin; Kristel Sleegers; Christine Van Broeckhoven; Laetitia Aerts; Peter Paul De Deyn; Sebastiaan Engelborghs
Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;33(3):807-22.
2013: Catarina Chester; Mamede de Carvalho; Lubina Dillen; Gabriel Miltenberger; Sónia Pereira; Christine Van Broeckhoven; Julie van der Zee; Alexandre de Mendonça
Rapidly progressive frontotemporal dementia and bulbar amyotrophic lateral sclerosis in Portuguese patients with C9orf72 mutation.
Amyotrophic lateral sclerosis & frontotemporal degeneration 2013;14(1):70-2.
2012: Lili-Naz Hazrati; Patricia L Brooks; Nathalie Brouwers; Marc Cruts; Mahdi Ghani; Christine Sato; Kristel Sleegers; Peter St George-Hyslop; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Ekaterina Rogaeva
Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.
Neurobiology of aging 2012;33(12):2949.e5-2949.e12.
2012: Tim Van Langenhove; Julie van der Zee; Christine Van Broeckhoven
The molecular basis of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum.
Annals of medicine 2012;44(8):817-28.
2012: Jessie Theuns; Ellen Corsmit; Patrick cras; David Crosiers; Peter Paul De Deyn; Luc Debaene; Jurgen Del-Favero; Ellen Elinck; Sebastiaan Engelborghs; Dirk Goossens; Maria Mattheijssens; Bram Meeus; Karen Nuytemans; Karin Peeters; Barbara A Pickut; Kristel Sleegers; Christine Van Broeckhoven
Guanosine triphosphate cyclohydrolase 1 promoter deletion causes dopa-responsive dystonia.
Movement disorders : official journal of the Movement Disorder Society 2012;27(11):1451-6.
2012: Anne Sieben; Christine Van Broeckhoven; Tim Van Langenhove; Paul Boon; Patrick cras; Peter Paul De Deyn; Sebastiaan Engelborghs; Jean-Jacques Martin; Patrick Santens; Marc Cruts
The genetics and neuropathology of frontotemporal lobar degeneration.
Acta neuropathologica 2012;124(3):353-72.
2012: Hans Wils; Sandra Pereson; Christine Van Broeckhoven; Debby Van Dam; Anja Capell; Ivy Cuijt; Peter P De Deyn; Christian Haass; Jonathan Janssens; Geert Joris; Gernot Kleinberger; Samir Kumar-Singh
Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.
The Journal of pathology 2012;228(1):67-76.
2012: Bram Meeus; Jessie Theuns; Christine Van Broeckhoven
The genetics of dementia with Lewy bodies: what are we missing?
Archives of neurology 2012;69(9):1113-8.
2012: Marc Cruts; Jessie Theuns; Christine Van Broeckhoven
Locus-specific mutation databases for neurodegenerative brain diseases.
Human mutation 2012;33(9):1340-4.
2012: Aline Verstraeten; Eline Wauters; Christine Van Broeckhoven; Rik Vandenberghe; Ellen Corsmit; Patrick cras; David Crosiers; Peter Paul De Deyn; Ellen Elinck; Sebastiaan Engelborghs; Maria Mattheijssens; Bram Meeus; Karin Peeters; Barbara A Pickut; Jessie Theuns
Contribution of VPS35 genetic variability to LBD in the Flanders-Belgian population.
Neurobiology of aging 2012;33(8):1844.e11-3.
2012: Tim Van Langenhove; Rik Vandenberghe; Marleen Van den Broeck; Julie van der Zee; Patrick cras; Marc Cruts; Peter P De Deyn; Peter De Jonghe; Sebastiaan Engelborghs; Maria Mattheijssens; Dirk Nuytten; Karin Peeters; Patrick Santens; Christine Van Broeckhoven
Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts.
Neurobiology of aging 2012;33(5):1004.e17-20.
2012: Bram Meeus; Karin Peeters; Barbara A Pickut; Ellen Corsmit; Patrick cras; David Crosiers; Peter Paul De Deyn; Ellen Elinck; Sebastiaan Engelborghs; Maria Mattheijssens; Christine Van Broeckhoven; Marleen Van den Broeck; Rik Vandenberghe; Aline Verstraeten; Jessie Theuns
DLB and PDD: a role for mutations in dementia and Parkinson disease genes?
Neurobiology of aging 2012;33(3):629.e5-629.e18.
2012: Nathalie Brouwers; Marc Cruts; Sebastiaan Engelborghs; J-C Lambert; Maria Mattheijssens; A Gil Montoya; F Pasquier; Karin Peeters; Kristel Sleegers; Rik Vandenberghe; P P De Deyn; C Van Cauwenberghe; N Le Bastard; P Amouyel; K Bettens; Christine Van Broeckhoven
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites.
Molecular psychiatry 2012;17(2):223-33.
2012: Elke Bogaert; Robert H Brown; Peter De Jonghe; Veerle Geelen; Jonathan D Glass; An Goris; John E Landers; Robin Lemmens; Judith Melki; Wim Robberecht; Christopher E Shaw; Kristel Sleegers; Agnieszka Slowik; Vincent Timmerman; Barbara Tomik; Bryan Joseph Traynor; Christine Van Broeckhoven; Philip Van Damme; Leonard H Van den Berg; Ammar Al-Chalabi; Peter M Andersen; Anna Birve; Michael A van Es; Nathalie Verpoorten; Ludo Van Den Bosch
Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis.
Neurobiology of aging 2012;33(2):418-20.
2012: Mikael Wikgren; Rolf Adolfsson; Johan Hultdin; Thomas Karlsson; Therese Nilbrink; Lars-Göran Nilsson; Katarina Nordfjäll; Lars Nyberg; Göran Roos; Kristel Sleegers; Christine Van Broeckhoven; Karl-Fredrik Norrback
APOE ε4 is associated with longer telomeres, and longer telomeres among ε4 carriers predicts worse episodic memory.
Neurobiology of aging 2012;33(2):335-44.
2012: David Crosiers; Peter Paul De Deyn; Pablo Martinez-Martin; Barbara A Pickut; Jessie Theuns; Christine Van Broeckhoven; K Ray Chaudhuri; Patrick cras
Non-motor symptoms in a Flanders-Belgian population of 215 Parkinson's disease patients as assessed by the Non-Motor Symptoms Questionnaire.
American journal of neurodegenerative disease 2012;1(2):160-7.
2012: Mikael Wikgren; Rolf Adolfsson; Johan Hultdin; Thomas Karlsson; Johanna Lind; Therese Nilbrink; Lars-Göran Nilsson; Lars Nyberg; Göran Roos; Kristel Sleegers; Christine Van Broeckhoven; Karl-Fredrik Norrback
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
PloS one 2012;7(4):e34292.
2012: Hans H Jung; Maria Grazia Spillantini; Johannes Streffer; Adriano Aguzzi; Juliane Bremer; Peter Brugger; R Anthony Crowther; Christine Van Broeckhoven; Kanwar Virdee; Markus Tolnay
Phenotypic variation of autosomal-dominant corticobasal degeneration.
European neurology 2012;67(3):142-50.
2012: Karolien Bettens; Nathalie Brouwers; Peter P De Deyn; Sebastiaan Engelborghs; Jean-Charles Lambert; Nathalie Le Bastard; Maria Mattheijssens; Richard Mayeux; Florence Pasquier; Karin Peeters; Ekaterina Rogaeva; Kristel Sleegers; Peter St George-Hyslop; Jasper Van Dongen; Rik Vandenberghe; Steven Vermeulen; Philippe Amouyel; Christine Van Broeckhoven
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.
Molecular neurodegeneration 2012;7():3.
2011: Arleen D Auerbach; John Burn; Jean-Jacques Cassiman; Mireille Claustres; Richard G H Cotton; Garry R Cutting; Johan T den Dunnen; Mona El-Ruby; Marc S Greenblatt; Finlay Macrae; Yoichi Matsubara; David L Rimoin; Aida Falcon Vargas; Mauno Vihinen; Christine Van Broeckhoven
Mutation (variation) databases and registries: a rationale for coordination of efforts.
Nature reviews. Genetics 2011;12(12):881; discussion 881.
2011: Manu Sharma; Peter A Silburn; Jessie Theuns; Tatsushi Toda; Hiroyuki Tomiyama; Ryan J Uitti; Christine Van Broeckhoven; Karin Wirdefeldt; Zbigniew Wszolek; Jan O Aasly; Nadine Abahuni; Grazia Annesi; Anna Rita Bentivoglio; Alexis Brice; Marie-Christine Chartier-Harlin; Francesa De Nigris; Alain Destée; Ana Djarmati; Alexis Elbaz; Matthew Farrer; Carlo Ferrarese; Thomas Gasser; J Mark Gibson; Suzana Gispert; Nobutaka Hattori; John Ioannidis; Barbara Jasinska-Myga; Christine Klein; Rejko Krüger; Jean-Charles Lambert; Anthony E Lang; Suzanne Lesage; Peter Lichtner; Timothy Lynch; Demetrius M Maraganore; George D Mellick; Grzegorz Opala; Aldo Quattrone; Olaf Riess; Chiara Riva; Ekaterina Rogaeva; Owen A Ross; Wataru Satake
Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease.
Neurobiology of aging 2011;32(11):2108.e1-5.
2011: Julie van der Zee; Christine Van Broeckhoven
TMEM106B a novel risk factor for frontotemporal lobar degeneration.
Journal of molecular neuroscience : MN 2011;45(3):516-21.
2011: David Crosiers; Jessie Theuns; Patrick cras; Christine Van Broeckhoven
Parkinson disease: insights in clinical, genetic and pathological features of monogenic disease subtypes.
Journal of chemical neuroanatomy 2011;42(2):131-41.
2011: E Genin; D Hannequin; O Hanon; S Helisalmi; M Hiltunen; M I Kamboh; J C Lambert; F Licastro; M Mancuso; I Mateo; B Nacmias; Francesco Panza; F Pasquier; P Piccardi; A Pilotto; E Porcellini; E Scarpini; D Seripa; G Siciliano; K Sleegers; Hilkka Soininen; V Solfrizzi; Sandro Sorbi; G Spalletta; G Tognoni; F Valdivieso; Christine Van Broeckhoven; S Vepsäläinen; D Wallon; V Alvarez; P Amouyel; G Annoni; B Arosio; C Berr; K Bettens; P Bosco; P Bossù; N Brouwers; M J Bullido; O Combarros; E Coto; Jean-François Dartigues; P De Deyn; Maria Del Zompo; B Dubois; S Engelborghs; J Epelbaum; R Ferri; N Fiévet; P Forti; A Frank-Garcia; D Galimberti; D Campion
APOE and Alzheimer disease: a major gene with semi-dominant inheritance.
Molecular psychiatry 2011;16(9):903-7.
2011: Daniel Pirici; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Samir Kumar-Singh
Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models.
Neurobiology of aging 2011;32(9):1579-87.
2011: Lenka Nosková; Anna Přistoupilová; Katherine B Sims; John F Staropoli; Viktor Stránecký; Jaana Tyynelä; Christine Van Broeckhoven; Julie van der Zee; Veronika Barešová; Milan Elleder; Hana Hartmannová; Helena Hůlková; Robert Ivanek; Helena Jahnová; Sara E Mole; Peter Nijssen; Stanislav Kmoch
Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosis.
American journal of human genetics 2011;89(2):241-52.
2011: Jonathan Janssens; Gernot Kleinberger; Hans Wils; Christine Van Broeckhoven
The role of mutant TAR DNA-binding protein 43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Biochemical Society transactions 2011;39(4):954-9.
2011: Takashi Saito; Kristel Sleegers; Takahiro Suemoto; Jiro Takano; Christine Van Broeckhoven; Kazuyuki Yamada; Nathalie Brouwers; Satoru Funamoto; Yasuo Ihara; Nobuhisa Iwata; Yukio Matsuba; Naomi Mihira; Per Nilsson; Masaki Nishimura; Takaomi C Saido
Potent amyloidogenicity and pathogenicity of Aβ43.
Nature neuroscience 2011;14(8):1023-32.
2011: Lujia Zhou; Nathalie Brouwers; Iryna Benilova; Annelies Vandersteen; Marc Mercken; Koen Van Laere; Philip Van Damme; David Demedts; Fred Van Leuven; Kristel Sleegers; Kerensa Broersen; Christine Van Broeckhoven; Rik Vandenberghe; Bart De Strooper
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.
EMBO molecular medicine 2011;3(5):291-302.
2011: Paul Hollingworth; Peter A Holmans; Clive Holmes; Nigel M Hooper; Michael Hüll; M Arfan Ikram; Dobril Ivanov; Frank Jessen; Karl-Heinz Jöckel; Lesley Jones; Nicola Jones; Palmi V Jonsson; Thorlakur Jonsson; John S K Kauwe; Patrick G Kehoe; Norman Klopp; Heike Kölsch; Johannes Kornhuber; Michael Krawczak; Jean-Charles Lambert; Mark Lathrop; Lenore J Launer; Brian Lawlor; Federico Licastro; Gill Livingston; Oscar L Lopez; Seth Love; Simon Lovestone; Michelle K Lupton; Aoibhinn Lynch; Wolfgang Maier; Michelangelo Mancuso; David Mann; Ignacio Mateo; Manuel Mayhaus; Kevin Mayo; Bernadette McGuinness; Andrew McQuillin; Simon Mead; Susanne Moebus; Kevin Morgan; John C Morris; Valentina Moskvina; Thomas W Mühleisen; Benedetta Nacmias; S Nicolhaus; Markus M Nöthen; Petra Nowotny; Michael O'Donovan; Michael J Owen; Jaspreet Singh Pahwa; V Shane Pankratz; Francesco Panza; Florence Pasquier; Peter A Passmore; Ronald C. Petersen; Paola Piccardi; Alberto Pilotto; Elisa Porcellini; John Powell; Petroula Proitsi; Alex Richards; Caterina Riehle; Matthias Riemenschneider; Martin N Rossor; David C Rubinsztein; Dan Rujescu; Eckart Rüther; Sigrid B Sando; Elio Scarpini; Stefan Schreiber; Britta Schürmann; Davide Seripa; Sudha Seshadri; Christopher E Shaw; Gabriele Siciliano; Rebecca Sims; Andrew B Singleton; Kristel Sleegers; A David Smith; Jon Snaedal; Hilkka Soininen; Vincenzo Solfrizzi; Sandro Sorbi; Hreinn Stefansson; Kari Stefansson; Stacy Steinberg; Alexandra Stretton; Charlene Thomas; Stephen Todd; Magda Tsolaki; Christophe Tzourio; Christine Van Broeckhoven; Hendrik van den Bussche; Cornelia M van Duijn; Emma R L C Vardy; Stefan Wagenpfeil; Donald Warden; H-Erich Wichmann; Caroline Widdowson; Gordon Wilcock; Jan O Aasly; Richard Abraham; Ammar Al-Chalabi; Annick Alpérovitch; Victoria Alvarez; Philippe Amouyel; Giorgio Annoni; Beatrice Arosio; Maria Barcikowska; Nicholas J Bass; Helen Beaumont; Claudine Berr; Karolien Bettens; Sigurbjörn Björnsson; Paolo Bosco; Paola Bossù; Carol Brayne; Monique Breteler; Alexis Brice; Kristelle S Brown; Maria J Bullido; Dominique Campion; Minerva M Carrasquillo; Jade Chapman; Vincent Chouraki; John Collinge; Onofre Combarros; Eliecer Coto; David Craig; Carlos Cruchaga; Jean-François Dartigues; Peter P De Deyn; Marc Delepine; Panagiotis Deloukas; Anita L DeStefano; Martin Dichgans; dennis dickson; Kimberley Dowzell; Sebastiaan Engelborghs; Jacques Epelbaum; Thomas M Feulner; Annette L Fitzpatrick; Nick C Fox; Ana Frank-Garcia; Patricia Friedrich; Lutz Frölich; Daniela Galimberti; John Gallacher; Benjamin Genier-Boley; Amy Gerrish; Ina Giegling; Michael Gill; Alison Goate; Neill R Graff-Radford; Rita Guerreiro; Hugh Gurling; Rhian Gwilliam; Harald Hampel; Marian L Hamshere; Didier Hannequin; Olivier Hanon; John Hardy; Denise Harold; Reiner Heun; Isabella Heuser; Mikko Hiltunen; Jens Wiltfang; Zbigniew K Wszolek; Steven G Younkin; Diana Zelenika; Julie Williams
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Nature genetics 2011;43(5):429-35.
2011: Alice S Chen-Plotkin; Maria Martinez-Lage; Patrick M A Sleiman; William Hu; Robert Greene; Elisabeth McCarty Wood; Shaoxu Bing; Murray Grossman; Gerard D Schellenberg; Kimmo J Hatanpaa; Myron F Weiner; Charles L White; William S Brooks; Glenda M Halliday; Jillian J Kril; Marla Gearing; Thomas Beach; Neill R Graff-Radford; dennis dickson; Rosa Rademakers; Bradley F Boeve; Stuart M Pickering-Brown; Julie Snowden; John C van Swieten; Peter Heutink; Harro Seelaar; Jill R Murrell; Bernardino Ghetti; Salvatore Spina; Jordan Grafman; Jeffrey A Kaye; Randall L Woltjer; Marsel Mesulam; Eileen Bigio; Albert Lladó; Bruce L Miller; Ainhoa Alzualde; Fermin Moreno; Jonathan D Rohrer; Ian R A Mackenzie; Howard H Feldman; Ronald L Hamilton; Marc Cruts; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Thomas D Bird; Nigel J Cairns; Alison Goate; Matthew P Frosch; Peter F Riederer; Nenad Bogdanovic; Virginia M-Y Lee; John Q Trojanowski; Vivianna M Van Deerlin
Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.
Archives of neurology 2011;68(4):488-97.
2011: Sara Rollinson; Jonathan D Rohrer; Julie van der Zee; Kristel Sleegers; Simon Mead; Sebastiaan Engelborghs; John Collinge; Peter P De Deyn; David M A Mann; Christine Van Broeckhoven; Stuart Pickering-Brown
No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration.
Neurobiology of aging 2011;32(4):754-5.
2011: Julie van der Zee; Tim Van Langenhove; Gernot Kleinberger; Kristel Sleegers; Sebastiaan Engelborghs; Rik Vandenberghe; Patrick Santens; Marleen Van den Broeck; Geert Joris; Jolien Brys; Maria Mattheijssens; Karin Peeters; Patrick Cras; Peter P De Deyn; Marc Cruts; Christine Van Broeckhoven
TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.
Brain : a journal of neurology 2011;134(Pt 3):808-15.
2011: Rejko Krüger; Manu Sharma; Olaf Riess; Thomas Gasser; Christine Van Broeckhoven; Jessie Theuns; Jan Aasly; Grazia Annesi; Anna Rita Bentivoglio; Alexis Brice; Ana Djarmati; Alexis Elbaz; Matthew Farrer; Carlo Ferrarese; J Mark Gibson; Georgios M Hadjigeorgiou; Nobutaka Hattori; John Ioannidis; Barbara Jasinska-Myga; Christine Klein; Jean-Charles Lambert; Suzanne Lesage; Juei-Jueng Lin; Timothy Lynch; George D Mellick; Francesa de Nigris; Grzegorz Opala; Alessandro Prigione; Aldo Quattrone; Owen A Ross; Wataru Satake; Peter A Silburn; Eng King Tan; Tatsushi Toda; Hiroyuki Tomiyama; Karin Wirdefeldt; Zbigniew Wszolek; Georgia Xiromerisiou; Demetrius M Maraganore
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
Neurobiology of aging 2011;32(3):548.e9-18.
2011: Anja Capell; Sabine Liebscher; Katrin Fellerer; Nathalie Brouwers; Michael Willem; Sven Lammich; Ilse Gijselinck; Tobias Bittner; Aaron M Carlson; Florenz Sasse; Brigitte Kunze; Heinrich Steinmetz; Rolf Jansen; Dorothee Dormann; Kristel Sleegers; Marc Cruts; Jochen Herms; Christine Van Broeckhoven; Christian Haass
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(5):1885-94.
2011: David Crosiers; Berten Ceulemans; Bram Meeus; Karen Nuytemans; Philippe Pals; Christine Van Broeckhoven; Patrick Cras; Jessie Theuns
Juvenile dystonia-parkinsonism and dementia caused by a novel ATP13A2 frameshift mutation.
Parkinsonism & related disorders 2011;17(2):135-8.
2011: Jean-Marc Burgunder; L Schöls; J Baets; P Andersen; T Gasser; Z Szolnoki; B Fontaine; Christine Van Broeckhoven; S Di Donato; P De Jonghe; T Lynch; C Mariotti; A Spinazzola; S J Tabrizi; C Tallaksen; M Zeviani; H F Harbo; J Finsterer
EFNS guidelines for the molecular diagnosis of neurogenetic disorders: motoneuron, peripheral nerve and muscle disorders.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2011;18(2):207-17.
2011: Bram Meeus; Karen Nuytemans; David Crosiers; Sebastiaan Engelborghs; Philippe Pals; Barbara A Pickut; Karin Peeters; Maria Mattheijssens; Ellen Corsmit; Patrick Cras; Peter Paul De Deyn; Jessie Theuns; Christine Van Broeckhoven
GIGYF2 has no major role in Parkinson genetic etiology in a Belgian population.
Neurobiology of aging 2011;32(2):308-12.
2011: Christiane Reitz; Rong Cheng; Ekaterina Rogaeva; Joseph H Lee; Shinya Tokuhiro; Fanggeng Zou; Karolien Bettens; Kristel Sleegers; Eng King Tan; Ryo Kimura; Nobuto Shibata; Heii Arai; M Ilyas Kamboh; Jonathan A Prince; Wolfgang Maier; Matthias Riemenschneider; Michael J Owen; Denise Harold; Paul Hollingworth; Elena Cellini; Sandro Sorbi; Benedetta Nacmias; Masatoshi Takeda; Margaret Pericak-Vance; Jonathan L Haines; Steven G Younkin; Julie Williams; Christine Van Broeckhoven; Lindsay A Farrer; Peter St George-Hyslop; Richard Mayeux
Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Archives of neurology 2011;68(1):99-106.
2010: Thomas Philips; Louis De Muynck; Hoai Nguyen Thi Thu; Bea Weynants; Peter Vanacker; Joke Dhondt; Kristel Sleegers; Helenius J Schelhaas; Marcel Verbeek; Rik Vandenberghe; Raf Sciot; Christine Van Broeckhoven; Diether Lambrechts; Fred Van Leuven; Ludo Van Den Bosch; Wim Robberecht; Philip Van Damme
Microglial upregulation of progranulin as a marker of motor neuron degeneration.
Journal of neuropathology and experimental neurology 2010;69(12):1191-200.
2010: Christine Van Broeckhoven
The future of genetic research on neurodegeneration.
Nature medicine 2010;16(11):1215-7.
2010: Gernot Kleinberger; Hans Wils; Peter Ponsaerts; Geert Joris; Jean-Pierre Timmermans; Christine Van Broeckhoven; Samir Kumar-Singh
Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures.
Journal of neurochemistry 2010;115(3):735-47.
2010: Dirk van West; Jurgen Del-Favero; Dirk Deboutte; Christine Van Broeckhoven; Stephan J Claes
Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population.
Psychiatry research 2010;179(1):64-8.
2010: Kristel Sleegers; Nathalie Brouwers; Christine Van Broeckhoven
Reply: Predicted pathogenic missense mutation of PGRN found in a normal control.
Annals of neurology 2010;68(1):119.
2010: Karen Nuytemans; Jessie Theuns; Marc Cruts; Christine Van Broeckhoven
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.
Human mutation 2010;31(7):763-80.
2010: Hazel Urwin; Keith A Josephs; Jonathan D Rohrer; Ian R Mackenzie; Manuela Neumann; Astrid Authier; Harro Seelaar; John C Van Swieten; Jeremy M Brown; Peter Johannsen; Jorgen E Nielsen; Ida E Holm; dennis dickson; Rosa Rademakers; Neill R Graff-Radford; Joseph E Parisi; Ronald C. Petersen; Kimmo J Hatanpaa; Charles L White; Myron F Weiner; Felix Geser; Vivianna M Van Deerlin; John Q Trojanowski; Bruce L Miller; William W Seeley; Julie van der Zee; Samir Kumar-Singh; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Eileen H Bigio; Han-Xiang Deng; Glenda M Halliday; Jillian J Kril; David G Munoz; D M A Mann; Stuart M Pickering-Brown; Valerie Doodeman; Gary Adamson; Shabnam Ghazi-Noori; Elizabeth M C Fisher; Janice L Holton; Tamas Revesz; Martin N Rossor; John Collinge; Simon Mead; Adrian M Isaacs
FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.
Acta neuropathologica 2010;120(1):33-41.
2010: Hazel Urwin; Astrid Authier; Jorgen E Nielsen; Daniel Metcalf; Caroline Powell; Kristina Froud; Denise S Malcolm; Ida Holm; Peter Johannsen; Jeremy Brown; Elizabeth M C Fisher; Julie van der Zee; Marc Bruyland; Christine Van Broeckhoven; John Collinge; Sebastian Brandner; Clare Futter; Adrian M Isaacs
Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations.
Human molecular genetics 2010;19(11):2228-38.
2010: Ilse Gijselinck; Sebastiaan Engelborghs; Githa Maes; Ivy Cuijt; Karin Peeters; Maria Mattheijssens; Geert Joris; Patrick Cras; Jean-Jacques Martin; Peter P De Deyn; Samir Kumar-Singh; Christine Van Broeckhoven; Marc Cruts
Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology 2010;67(5):606-16.
2010: Raf Brouns; Vincent Thijs; François Eyskens; Marleen Van den Broeck; Shibeshih Belachew; Christine Van Broeckhoven; Patricia Redondo; Dimitri Hemelsoet; Arnaud Fumal; Sandrine Jeangette; Werner Verslegers; Robert Baker; derralynn hughes; Peter Paul De Deyn
Belgian Fabry study: prevalence of Fabry disease in a cohort of 1000 young patients with cerebrovascular disease.
Stroke; a journal of cerebral circulation 2010;41(5):863-8.
2010: Jean-Marc Burgunder; J Finsterer; Z Szolnoki; B Fontaine; J Baets; Christine Van Broeckhoven; S Di Donato; P De Jonghe; T Lynch; C Mariotti; L Schöls; A Spinazzola; S J Tabrizi; C Tallaksen; M Zeviani; H F Harbo; T Gasser
EFNS guidelines on the molecular diagnosis of channelopathies, epilepsies, migraine, stroke, and dementias.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2010;17(5):641-8.
2010: Karolien Bettens; Kristel Sleegers; Christine Van Broeckhoven
Current status on Alzheimer disease molecular genetics: from past, to present, to future.
Human molecular genetics 2010;19(R1):R4-R11.
2010: Vivianna M Van Deerlin; Patrick M A Sleiman; Maria Martinez-Lage; Alice Chen-Plotkin; Li-San Wang; Neill R Graff-Radford; dennis dickson; Rosa Rademakers; Bradley F Boeve; Murray Grossman; Steven E Arnold; D M A Mann; Stuart M Pickering-Brown; Harro Seelaar; Peter Heutink; John C van Swieten; Jill R Murrell; Bernardino Ghetti; Salvatore Spina; Jordan Grafman; John R Hodges; Maria Grazia Spillantini; Sid Gilman; Andrew P Lieberman; Jeffrey A Kaye; Randall L Woltjer; Eileen H Bigio; Marsel Mesulam; Safa Al-Sarraj; Claire Troakes; Roger N Rosenberg; Charles L White; Isidro Ferrer; Albert Lladó; Manuela Neumann; Hans A Kretzschmar; Christine Marie Hulette; Kathleen A Welsh-Bohmer; Bruce L Miller; Ainhoa Alzualde; Adolfo Lopez de Munain; Ann C McKee; Marla Gearing; Allan Levey; James J Lah; John Hardy; Jonathan D Rohrer; Tammaryn Lashley; Ian R A Mackenzie; Howard H Feldman; Ronald L Hamilton; Steven T DeKosky; Julie van der Zee; Samir Kumar-Singh; Christine Van Broeckhoven; Richard Mayeux; Jean Paul G Vonsattel; Juan C Troncoso; Jillian J Kril; John B J Kwok; Glenda M Halliday; Thomas D Bird; Paul Geoffrey Ince; Pamela J Shaw; Nigel J Cairns; John C Morris; Catriona Ann McLean; Charles DeCarli; William G Ellis; Stefanie H Freeman; Matthew P Frosch; John H Growdon; Daniel P Perl; Mary Sano; David A Bennett; Julie A Schneider; Thomas Beach; Eric Reiman; Bryan Woodruff; Jeffrey L Cummings; Harry V Vinters; Carol A Miller; Helena C Chui; Irina Alafuzoff; Päivi Hartikainen; Danielle Seilhean; Douglas Galasko; Eliezer Masliah; Carl W Cotman; M Teresa Tuñón; M Cristina Caballero Martínez; David G Munoz; Steven L Carroll; Daniel Marson; Peter F Riederer; Nenad Bogdanovic; Gerard D Schellenberg; Hakon Hakonarson; John Q Trojanowski; Virginia M-Y Lee
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
Nature genetics 2010;42(3):234-9.
2010: Hans Wils; Gernot Kleinberger; Jonathan Janssens; Sandra Pereson; Geert Joris; Ivy Cuijt; Veerle Smits; Chantal Ceuterick-de Groote; Christine Van Broeckhoven; Samir Kumar-Singh
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3858-63.
2010: T Van Langenhove; Julie van der Zee; Kristel Sleegers; Sebastiaan Engelborghs; Rik Vandenberghe; Ilse Gijselinck; Marleen Van den Broeck; Maria Mattheijssens; Karin Peeters; Peter Paul De Deyn; Marc Cruts; Christine Van Broeckhoven
Genetic contribution of FUS to frontotemporal lobar degeneration.
Neurology 2010;74(5):366-71.
2010: Kristel Sleegers; Nathalie Brouwers; Christine Van Broeckhoven
Role of progranulin as a biomarker for Alzheimer's disease.
Biomarkers in medicine 2010;4(1):37-50.
2010: Kristel Sleegers; Jean-Charles Lambert; Lars Bertram; Marc Cruts; Philippe Amouyel; Christine Van Broeckhoven
The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects.
Trends in genetics : TIG 2010;26(2):84-93.
2010: Thomas Gasser; J Finsterer; J Baets; Christine Van Broeckhoven; S Di Donato; B Fontaine; P De Jonghe; A Lossos; T Lynch; C Mariotti; L Schöls; A Spinazzola; Z Szolnoki; S J Tabrizi; C M E Tallaksen; M Zeviani; J-M Burgunder; H F Harbo
EFNS guidelines on the molecular diagnosis of ataxias and spastic paraplegias.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2010;17(2):179-88.
2010: Evangelos Evangelou; Demetrius M Maraganore; Grazia Annesi; Laura Brighina; Alexis Brice; Alexis Elbaz; Carlo Ferrarese; Georgios M Hadjigeorgiou; Rejko Krueger; Jean-Charles Lambert; Suzanne Lesage; Katerina Markopoulou; George D Mellick; Bram Meeus; Nancy L Pedersen; Aldo Quattrone; Christine Van Broeckhoven; Manu Sharma; Peter A Silburn; Eng-King Tan; Karin Wirdefeldt; John Ioannidis
Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(1):220-8.
2010: Jean-Charles Lambert; Kristel Sleegers; Antonio González-Pérez; Martin Ingelsson; Gary Beecham; Mikko Hiltunen; Onofre Combarros; Maria J Bullido; Nathalie Brouwers; Karolien Bettens; Claudine Berr; Florence Pasquier; Florence Richard; Steven T DeKosky; Didier Hannequin; Jonathan L Haines; Gloria Tognoni; Nathalie Fiévet; Jean-François Dartigues; Christophe Tzourio; Sebastiaan Engelborghs; Beatrice Arosio; Elicer Coto; Peter De Deyn; Maria Del Zompo; Ignacio Mateo; Merce Boada; Carmen Antunez; Jesus Lopez-Arrieta; Jacques Epelbaum; Brit-Maren Michaud Schjeide; Ana Frank-Garcia; Vilmentas Giedraitis; Seppo Helisalmi; Elisa Porcellini; Alberto Pilotto; Paola Forti; Raffaele Ferri; Marc Delepine; Diana Zelenika; Mark Lathrop; Elio Scarpini; Gabriele Siciliano; Vincenzo Solfrizzi; Sandro Sorbi; Gianfranco Spalletta; Giovanni Ravaglia; Fernando Valdivieso; Saila Vepsäläinen; Victoria Alvarez; Paolo Bosco; Michelangelo Mancuso; Francesco Panza; Benedetta Nacmias; Paola Bossù; Olivier Hanon; Paola Piccardi; Giorgio Annoni; David Mann; Philippe Marambaud; Davide Seripa; Daniela Galimberti; Rudolph E Tanzi; Lars Bertram; Corinne Lendon; Lars Lannfelt; Federico Licastro; Dominique Campion; Margaret Pericak-Vance; Hilkka Soininen; Christine Van Broeckhoven; Annick Alpérovitch; Agustin Ruiz; M Ilyas Kamboh; Philippe Amouyel
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.
Journal of Alzheimer's disease : JAD 2010;22(1):247-55.
2010: Nathalie Brouwers; Karolien Bettens; Ilse Gijselinck; Sebastiaan Engelborghs; Barbara A Pickut; Helen Van Miegroet; Ana Gil Montoya; Maria Mattheijssens; Karin Peeters; Peter P De Deyn; Marc Cruts; Kristel Sleegers; Christine Van Broeckhoven
Contribution of TARDBP to Alzheimer's disease genetic etiology.
Journal of Alzheimer's disease : JAD 2010;21(2):423-30.
2010: Kristel Sleegers; Marc Cruts; Christine Van Broeckhoven
Molecular pathways of frontotemporal lobar degeneration.
Annual review of neuroscience 2010;33():71-88.
2010: Karolien Bettens; Nathalie Brouwers; Helen Van Miegroet; Ana Gil; Sebastiaan Engelborghs; Peter P De Deyn; Rik Vandenberghe; Christine Van Broeckhoven; Kristel Sleegers
Follow-up study of susceptibility loci for Alzheimer's disease and onset age identified by genome-wide association.
Journal of Alzheimer's disease : JAD 2010;19(4):1169-75.
2010: Bram Meeus; Karen Nuytemans; David Crosiers; Sebastiaan Engelborghs; Karin Peeters; Maria Mattheijssens; Ellen Elinck; Ellen Corsmit; Peter Paul De Deyn; Christine Van Broeckhoven; Jessie Theuns
Comprehensive genetic and mutation analysis of familial dementia with Lewy bodies linked to 2q35-q36.
Journal of Alzheimer's disease : JAD 2010;20(1):197-205.
2009: J Finsterer; H F Harbo; J Baets; Christine Van Broeckhoven; S Di Donato; B Fontaine; P De Jonghe; A Lossos; T Lynch; C Mariotti; L Schöls; A Spinazzola; Z Szolnoki; S J Tabrizi; C M E Tallaksen; M Zeviani; J-M Burgunder; T Gasser
EFNS guidelines on the molecular diagnosis of mitochondrial disorders.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2009;16(12):1255-64.
2009: Saeed Bohlega; G Van Goethem; Abdulaziz Al-Semari; A Löfgren; Mohamed Al-Hamed; Christine Van Broeckhoven; Marios Kambouris
Novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia and multisystem failure.
Neuromuscular disorders : NMD 2009;19(12):845-8.
2009: Raf Brouns; C Ceuterick-de Groote; K De Boeck; F Eyskens; Christine Van Broeckhoven; Marleen Van den Broeck; P P De Deyn
Fabry disease in a patient with Turner syndrome.
Journal of inherited metabolic disease 2009;32 Suppl 1():S45-8.
2009: Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Tim De Pooter; Peter P De Deyn; Kristel Sleegers; Christine Van Broeckhoven
DNMBP is genetically associated with Alzheimer dementia in the Belgian population.
Neurobiology of aging 2009;30(12):2000-9.
2009: Latchezar Dintchov Traykov; Shima Mehrabian; Marleen Van den Broeck; Margarita Radoslavova Raycheva; Marc Cruts; Albena Kirilova Jordanova; Christine Van Broeckhoven
Novel PSEN1 mutation in a Bulgarian patient with very early-onset Alzheimer's disease, spastic paraparesis, and extrapyramidal signs.
American journal of Alzheimer's disease and other dementias 2009;24(5):404-7.
2009: Jean-Charles Lambert; Simon Heath; Gael Even; Dominique Campion; Kristel Sleegers; Mikko Hiltunen; Onofre Combarros; Diana Zelenika; Maria J Bullido; Béatrice Tavernier; Luc Letenneur; Karolien Bettens; Claudine Berr; Florence Pasquier; Nathalie Fiévet; Pascale Barberger-Gateau; Sebastiaan Engelborghs; Peter De Deyn; Ignacio Mateo; Ana Franck; Seppo Helisalmi; Elisa Porcellini; Olivier Hanon; Marian M de Pancorbo; Corinne Lendon; carole dufouil; Céline Jaillard; Thierry Leveillard; Victoria Alvarez; Paolo Bosco; Michelangelo Mancuso; Francesco Panza; Benedetta Nacmias; Paola Bossù; Paola Piccardi; Giorgio Annoni; Davide Seripa; Daniela Galimberti; Didier Hannequin; Federico Licastro; Hilkka Soininen; Karen Ritchie; Hélène Blanché; Jean-François Dartigues; Christophe Tzourio; Ivo Gut; Christine Van Broeckhoven; Annick Alpérovitch; Mark Lathrop; Philippe Amouyel
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
Nature genetics 2009;41(10):1094-9.
2009: Denise Harold; Richard Abraham; Paul Hollingworth; Rebecca Sims; Amy Gerrish; Marian L Hamshere; Jaspreet Singh Pahwa; Valentina Moskvina; Kimberley Dowzell; Amy Williams; Nicola Jones; Charlene Thomas; Alexandra Stretton; Angharad R Morgan; Simon Lovestone; John Powell; Petroula Proitsi; Michelle K Lupton; Carol Brayne; David C Rubinsztein; Michael Gill; Brian Lawlor; Aoibhinn Lynch; Kevin Morgan; Kristelle S Brown; Peter A Passmore; David Craig; Bernadette McGuinness; Stephen Todd; Clive Holmes; D M A Mann; A David Smith; Seth Love; Patrick G Kehoe; John Hardy; Simon Mead; Nick C Fox; Martin N Rossor; John Collinge; Wolfgang Maier; Frank Jessen; Britta Schürmann; Hendrik van den Bussche; Isabella Heuser; Johannes Kornhuber; Jens Wiltfang; Martin Dichgans; Lutz Froelich; Harald Hampel; Michael Hüll; Dan Rujescu; Alison Goate; John S K Kauwe; Carlos Cruchaga; Petra Nowotny; John C Morris; Kevin Mayo; Kristel Sleegers; Karolien Bettens; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Gillian Livingston; Nicholas J Bass; Hugh Gurling; Andrew McQuillin; Rhian Gwilliam; Panagiotis Deloukas; Ammar Al-Chalabi; Christopher Shaw; Magda Tsolaki; Andrew Singleton; Rita Guerreiro; Thomas W Mühleisen; Markus M Nöthen; Susanne Moebus; Karl-Heinz Jöckel; Norman Klopp; H-Erich Wichmann; Minerva M Carrasquillo; V Shane Pankratz; Steven G Younkin; Peter A Holmans; Michael O'Donovan; Michael J Owen; Julie Williams
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Nature genetics 2009;41(10):1088-93.
2009: Sandra Pereson; Hans Wils; Gernot Kleinberger; Eileen McGowan; Mado Vandewoestyne; Bianca Van Broeck; Geert Joris; Ivy Cuijt; Dieter Deforce; Michael Hutton; Christine Van Broeckhoven; Samir Kumar-Singh
Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.
The Journal of pathology 2009;219(2):173-81.
2009: Julie van der Zee; Daniel Pirici; T Van Langenhove; Sebastiaan Engelborghs; Rik Vandenberghe; M Hoffmann; G Pusswald; Marleen Van den Broeck; Karin Peeters; Maria Mattheijssens; Jean-Jacques Martin; Peter Paul De Deyn; Marc Cruts; D Haubenberger; Samir Kumar-Singh; A Zimprich; Christine Van Broeckhoven
Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His.
Neurology 2009;73(8):626-32.
2009: Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Helen Van Miegroet; Peter P De Deyn; Jessie Theuns; Kristel Sleegers; Christine Van Broeckhoven
APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.
Human mutation 2009;30(8):1207-13.
2009: Ilse Gijselinck; Kristel Sleegers; Sebastiaan Engelborghs; Wim Robberecht; Jean-Jacques Martin; Rik Vandenberghe; Raf Sciot; Bart Dermaut; Dirk Goossens; Julie van der Zee; Tim De Pooter; Jurgen Del-Favero; Patrick Santens; Peter De Jonghe; Peter P De Deyn; Christine Van Broeckhoven; Marc Cruts
Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS.
Neurobiology of aging 2009;30(8):1329-31.
2009: Hanne F Harbo; J Finsterer; J Baets; Christine Van Broeckhoven; S Di Donato; B Fontaine; P De Jonghe; A Lossos; T Lynch; C Mariotti; L Schöls; A Spinazzola; Z Szolnoki; S J Tabrizi; C M E Tallaksen; M Zeviani; J-M Burgunder; T Gasser
EFNS guidelines on the molecular diagnosis of neurogenetic disorders: general issues, Huntington's disease, Parkinson's disease and dystonias.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2009;16(7):777-85.
2009: Karen Nuytemans; Bram Meeus; David Crosiers; Nathalie Brouwers; Dirk Goossens; Sebastiaan Engelborghs; Philippe Pals; Barbara A Pickut; Marleen Van den Broeck; Ellen Corsmit; Patrick Cras; Peter P De Deyn; Jurgen Del-Favero; Christine Van Broeckhoven; Jessie Theuns
Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.
Human mutation 2009;30(7):1054-61.
2009: Kristel Sleegers; Nathalie Brouwers; Philip Van Damme; Sebastiaan Engelborghs; Ilse Gijselinck; Julie van der Zee; Karin Peeters; Maria Mattheijssens; Marc Cruts; Rik Vandenberghe; Peter P De Deyn; Wim Robberecht; Christine Van Broeckhoven
Serum biomarker for progranulin-associated frontotemporal lobar degeneration.
Annals of neurology 2009;65(5):603-9.
2009: Dirk van West; Jurgen Del-Favero; Dirk Deboutte; Christine Van Broeckhoven; Stephan J Claes
Arginine vasopressin receptor gene-based single-nucleotide polymorphism analysis in attention deficit hyperactivity disorder.
Psychiatric genetics 2009;19(2):102-3.
2009: Kristel Sleegers; Nathalie Brouwers; Karolien Bettens; Sebastiaan Engelborghs; Helen van Miegroet; Peter P De Deyn; Christine Van Broeckhoven
No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.
Human mutation 2009;30(4):E570-4.
2009: Kristel Sleegers; Christine Van Broeckhoven
Motor-neuron disease: Rogue gene in the family.
Nature 2009;458(7237):415-7.
2009: F Gankam Kengne; M Vokaer; P Fery; M Abramowicz; I Massat; M Van den Broeck; Christine Van Broeckhoven; J-C Bier
Pure progressive amnesia as variant of genetically proven Alzheimer disease.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2009;16(2):e9-10.
2009: Kristel Sleegers; Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Helen van Miegroet; Peter P De Deyn; Christine Van Broeckhoven
Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.
Human mutation 2009;30(2):E338-44.
2009: Wim Vandenberghe; Koen Van Laere; Frederik Debruyne; Christine Van Broeckhoven; Gert Van Goethem
Neurodegenerative Parkinsonism and progressive external ophthalmoplegia with a Twinkle mutation.
Movement disorders : official journal of the Movement Disorder Society 2009;24(2):308-9.
2009: Fan Liu; M Arfan Ikram; A Cecile J W Janssens; Maaike Schuur; Inge de Koning; Aaron Isaacs; Maksim Struchalin; Andre G Uitterlinden; Johan T den Dunnen; Kristel Sleegers; Karolien Bettens; Christine Van Broeckhoven; John C van Swieten; Albert Hofman; Ben A Oostra; Yurii Aulchenko; Monique Breteler; Cornelia M van Duijn
A study of the SORL1 gene in Alzheimer's disease and cognitive function.
Journal of Alzheimer's disease : JAD 2009;18(1):51-64.
2009: Alice Matimba; Jurgen Del-Favero; Christine Van Broeckhoven; Collen M Masimirembwa
Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects.
Human genomics 2009;3(2):169-90.
2008: Bianca Van Broeck; Greet Vanhoutte; Ivy Cuijt; Sandra Pereson; Geert Joris; Jean-Pierre Timmermans; Annemie Van der Linden; Christine Van Broeckhoven; Samir Kumar-Singh
Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations.
Neuroscience letters 2008;447(2-3):143-7.
2008: Yurii Aulchenko; Ilse A Hoppenbrouwers; Sreeram V Ramagopalan; Linda Broer; Naghmeh Jafari; Jan Hillert; Jenny Link; Wangko Lundström; Eva Greiner; A Dessa Sadovnick; Dirk Goossens; Christine Van Broeckhoven; Jurgen Del-Favero; George C Ebers; Ben A Oostra; C.M. Duijn; Rogier Q Hintzen
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
Nature genetics 2008;40(12):1402-3.
2008: Ilse Gijselinck; Christine Van Broeckhoven; Marc Cruts
Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update.
Human mutation 2008;29(12):1373-86.
2008: Julie van der Zee; Kristel Sleegers; Christine Van Broeckhoven
Invited article: the Alzheimer disease-frontotemporal lobar degeneration spectrum.
Neurology 2008;71(15):1191-7.
2008: K Nuytemans; Philippe Pals; Kristel Sleegers; Sebastiaan Engelborghs; Ellen Corsmit; Karin Peeters; Barbara A Pickut; Maria Mattheijssens; Patrick Cras; Peter Paul De Deyn; Jessie Theuns; Christine Van Broeckhoven
Progranulin variability has no major role in Parkinson disease genetic etiology.
Neurology 2008;71(15):1147-51.
2008: F Hoche; Kay Seidel; Ewout R Brunt; Georg Auburger; Ludger Schöls; Katrin Bürk; Rob A I de Vos; W den Dunnen; I Bechmann; R Egensperger; Christine Van Broeckhoven; Kristin Gierga; Thomas Deller; Udo Rüb
Involvement of the auditory brainstem system in spinocerebellar ataxia type 2 (SCA2), type 3 (SCA3) and type 7 (SCA7).
Neuropathology and applied neurobiology 2008;34(5):479-91.
2008: Nathalie Brouwers; Kristel Sleegers; Sebastiaan Engelborghs; Sebastian Maurer-Stroh; Ilse Gijselinck; Julie van der Zee; Barbara A Pickut; Marleen Van den Broeck; Maria Mattheijssens; Karin Peeters; J Schymkowitz; Frederic Rousseau; Jean-Jacques Martin; Marc Cruts; Peter Paul De Deyn; Christine Van Broeckhoven
Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
Neurology 2008;71(9):656-64.
2008: Kristel Sleegers; Nathalie Brouwers; Sebastian Maurer-Stroh; M A van Es; P Van Damme; P W J van Vught; Julie van der Zee; Sally Serneels; Tim De Pooter; Marleen Van den Broeck; Marc Cruts; J Schymkowitz; Peter De Jonghe; Frederic Rousseau; L H van den Berg; Wim Robberecht; Christine Van Broeckhoven
Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
Neurology 2008;71(4):253-9.
2008: Kristel Sleegers; Samir Kumar-Singh; Marc Cruts; Christine Van Broeckhoven
Molecular pathogenesis of frontotemporal lobar degeneration: basic science seminar in neurology.
Archives of neurology 2008;65(6):700-4.
2008: Veerle Bogaerts; Karen Nuytemans; Reumers Joke; Philippe Pals; Sebastiaan Engelborghs; Barbara A Pickut; Ellen Corsmit; Karin Peeters; Joost Schymkowitz; Peter Paul De Deyn; Patrick Cras; Frederic Rousseau; Jessie Theuns; Christine Van Broeckhoven
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease.
Human mutation 2008;29(6):832-40.
2008: Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Kristel Sleegers
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.
Human mutation 2008;29(5):769-70.
2008: Alejandro Arias-Vásquez; Yurii Aulchenko; Aaron Isaacs; Andy van Oosterhout; Kristel Sleegers; Albert Hofman; Christine Van Broeckhoven; Ben A Oostra; Monique Breteler; C.M. Duijn
Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study.
Journal of neurology 2008;255(5):655-62.
2008: K Haugarvoll; R Rademakers; Jennifer Kachergus; K Nuytemans; O A Ross; J M Gibson; E-K Tan; C Gaig; E Tolosa; S Goldwurm; M Guidi; Giulio Riboldazzi; L Brown; U Walter; R Benecke; Daniela Berg; T Gasser; J Theuns; P Pals; Patrick cras; P Paul De Deyn; S Engelborghs; B Pickut; Ryan Uitti; T Foroud; W C Nichols; J Hagenah; Christine Klein; Amir Samii; Cyrus Zabetian; Vincenzo Bonifati; Christine Van Broeckhoven; Matthew J Farrer; Zbigniew K Wszolek
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.
Neurology 2008;70(16 Pt 2):1456-60.
2008: Marc Cruts; Christine Van Broeckhoven
Loss of progranulin function in frontotemporal lobar degeneration.
Trends in genetics : TIG 2008;24(4):186-94.
2008: Karen Nuytemans; Rosa Rademakers; Jessie Theuns; Philippe Pals; Sebastiaan Engelborghs; Barbara A Pickut; Tim De Pooter; Karin Peeters; Maria Mattheijssens; Marleen Van den Broeck; Patrick Cras; Peter Paul De Deyn; Christine Van Broeckhoven
Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients.
European journal of human genetics : EJHG 2008;16(4):471-9.
2008: Udo Rüb; Ewout R Brunt; Kay Seidel; Kristin Gierga; C M Mooy; M Kettner; Christine Van Broeckhoven; I Bechmann; A R La Spada; Ludger Schöls; W den Dunnen; Rob A I de Vos; Thomas Deller
Spinocerebellar ataxia type 7 (SCA7): widespread brain damage in an adult-onset patient with progressive visual impairments in comparison with an adult-onset patient without visual impairments.
Neuropathology and applied neurobiology 2008;34(2):155-68.
2008: Tine Venken; M Alaerts; Daniel Souery; Dirk Goossens; Sam Sluijs; R Navon; Christine Van Broeckhoven; Julien Mendlewicz; Jurgen Del-Favero; Stephan J Claes
Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families.
Molecular psychiatry 2008;13(4):442-50.
2008: Isabelle Le Ber; Agnès Camuzat; Didier Hannequin; Florence Pasquier; Eric Guedj; Anne Rovelet-Lecrux; Valerie Hahn-Barma; Julie van der Zee; Fabienne Clot; Serge Bakchine; Michèle Puel; Mustapha Ghanim; Lucette Lacomblez; Jacqueline Mikol; Vincent Deramecourt; Pascal Lejeune; Vincent de La Sayette; Serge Belliard; Martine Vercelletto; Christian Meyrignac; Christine Van Broeckhoven; jean-charles lambert; Patrice Verpillat; Dominique Campion; Marie-Odile Habert; Bruno Dubois; Alexis Brice
Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study.
Brain : a journal of neurology 2008;131(Pt 3):732-46.
2008: Veerle Bogaerts; Jessie Theuns; Christine Van Broeckhoven
Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria?
Genes, brain, and behavior 2008;7(2):129-51.
2008: Bianca Van Broeck; Greetje Vanhoutte; Daniel Pirici; Debby Van Dam; Hans Wils; Ivy Cuijt; Krist'l Vennekens; Monika Zabielski; Andrej Michalik; Jessie Theuns; Peter Paul De Deyn; Annemie Van der Linden; Christine Van Broeckhoven; Samir Kumar-Singh
Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
Neurobiology of aging 2008;29(2):241-52.
2008: Julie van der Zee; Hazel Urwin; Sebastiaan Engelborghs; Marc Bruyland; Rik Vandenberghe; Bart Dermaut; Tim De Pooter; Karin Peeters; Patrick Santens; Peter P De Deyn; Elizabeth M C Fisher; John Collinge; Adrian M Isaacs; Christine Van Broeckhoven
CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro.
Human molecular genetics 2008;17(2):313-22.
2008: I H G B Ramakers; Pieter Jelle Visser; Pauline Aalten; Otto Bekers; K Sleegers; Christine Van Broeckhoven; Jelle Jolles; Frans Verhey
The association between APOE genotype and memory dysfunction in subjects with mild cognitive impairment is related to age and Alzheimer pathology.
Dementia and geriatric cognitive disorders 2008;26(2):101-8.
2008: Nathalie Brouwers; Kristel Sleegers; Christine Van Broeckhoven
Molecular genetics of Alzheimer's disease: an update.
Annals of medicine 2008;40(8):562-83.
2008: J Persson; Johanna Lind; A Larsson; M Ingvar; Kristel Sleegers; Christine Van Broeckhoven; Rolf Adolfsson; Lars-Göran Nilsson; Lars Nyberg
Altered deactivation in individuals with genetic risk for Alzheimer's disease.
Neuropsychologia 2008;46(6):1679-87.
2008: Jessie Theuns; Christine Van Broeckhoven
alpha-Synuclein gene duplications in sporadic Parkinson disease.
Neurology 2008;70(1):7-9.
2008: Ilse Gijselinck; Julie van der Zee; Sebastiaan Engelborghs; Dirk Goossens; Karin Peeters; Maria Mattheijssens; Ellen Corsmit; Jurgen Del-Favero; Peter Paul De Deyn; Christine Van Broeckhoven; Marc Cruts
Progranulin locus deletion in frontotemporal dementia.
Human mutation 2008;29(1):53-8.
2008: Michael A van Es; Paul van Vught; Hylke M Blauw; Lude Franke; Christiaan G J Saris; Ludo Van Den Bosch; Sonja W de Jong; Vianney de Jong; Frank Baas; Ruben van't Slot; Robin Lemmens; H Jurgen Schelhaas; Anna Birve; Kristel Sleegers; Christine Van Broeckhoven; Jennifer C Schymick; Bryan Joseph Traynor; J H J Wokke; Cisca Wijmenga; Wim Robberecht; Peter M Andersen; Jan Veldink; Roel A Ophoff; Leonard H Van den Berg
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
Nature genetics 2008;40(1):29-31.
2007: Robert Lyle; Paola Prandini; Kazutoyo Osoegawa; Boudewijn ten Hallers; Sean Humphray; Baoli Zhu; Eduardo Eyras; Robert Castelo; Christine P Bird; Sarantis Gagos; Carol Scott; Antony Cox; Samuel Deutsch; Catherine Ucla; Marc Cruts; Sophie Dahoun; Xinwei She; Frederique Bena; Sheng-Yue Wang; Christine Van Broeckhoven; Evan E Eichler; Roderic Guigo; Jane Rogers; Pieter J de Jong; Alexandre Reymond; Stylianos E Antonarakis
Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21.
Genome research 2007;17(11):1690-6.
2007: Nathalie Brouwers; Karen Nuytemans; Julie van der Zee; Ilse Gijselinck; Sebastiaan Engelborghs; Jessie Theuns; Samir Kumar-Singh; Barbara A Pickut; Philippe Pals; Bart Dermaut; Veerle Bogaerts; Tim De Pooter; Sally Serneels; Marleen Van den Broeck; Ivy Cuijt; Maria Mattheijssens; Karin Peeters; Raf Sciot; Jean-Jacques Martin; Patrick Cras; Patrick Santens; Rik Vandenberghe; Peter Paul De Deyn; Marc Cruts; Christine Van Broeckhoven; Kristel Sleegers
Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.
Archives of neurology 2007;64(10):1436-46.
2007: Michael A van Es; Paul van Vught; Hylke M Blauw; Lude Franke; Christiaan G Saris; Peter M Andersen; Ludo Van Den Bosch; Sonja W de Jong; Ruben van 't Slot; Anna Birve; Robin Lemmens; Vianney de Jong; Frank Baas; H Jurgen Schelhaas; Kristel Sleegers; Christine Van Broeckhoven; J H J Wokke; Cisca Wijmenga; Wim Robberecht; Jan Veldink; Roel A Ophoff; Leonard H Van den Berg
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.
Lancet neurology 2007;6(10):869-77.
2007: Filip Van Den Eede; Tine Venken; Ann Van Den Bogaert; Jurgen Del-Favero; Karl-Fredrik Norrback; Lars-Göran Nilsson; Rolf Adolfsson; Christine Van Broeckhoven; Stephan J Claes
Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder.
Psychiatric genetics 2007;17(5):304-7.
2007: Filip Van Den Eede; Tine Venken; Jurgen Del-Favero; Karl-Fredrik Norrback; Daniel Souery; Lars-Göran Nilsson; Bart Van den Bossche; Wouter Hulstijn; Bernard Sabbe; Paul Cosyns; Julien Mendlewicz; Rolf Adolfsson; Christine Van Broeckhoven; Stephan J Claes
Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder.
Psychiatry research 2007;153(1):17-25.
2007: Anna Sundström; Lars-Göran Nilsson; Marc Cruts; Rolf Adolfsson; Christine Van Broeckhoven; Lars Nyberg
Fatigue before and after mild traumatic brain injury: pre-post-injury comparisons in relation to Apolipoprotein E.
Brain injury : [BI] 2007;21(10):1049-54.
2007: Isabelle Massat; Bernard Lerer; Daniel Souery; Douglas Blackwood; Walter Muir; RAdka Kaneva; Markus M Nöthen; Lilijana Oruc; George N Papadimitriou; Dimitris G Dikeos; Alessandro Serretti; Frank Bellivier; J L Golmard; vihra milanova; Jurgen Del-Favero; Christine Van Broeckhoven; Julien Mendlewicz
HTR2C (cys23ser) polymorphism influences early onset in bipolar patients in a large European multicenter association study.
Molecular psychiatry 2007;12(9):797-8.
2007: Veerle Bogaerts; Sebastiaan Engelborghs; Samir Kumar-Singh; Dirk Goossens; Barbara A Pickut; Julie van der Zee; Kristel Sleegers; Karin Peeters; Jean-Jacques Martin; Jurgen Del-Favero; Thomas Gasser; dennis dickson; Zbigniew K Wszolek; Peter Paul De Deyn; Jessie Theuns; Christine Van Broeckhoven
A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder.
Brain : a journal of neurology 2007;130(Pt 9):2277-91.
2007: Sebastiaan Engelborghs; Kristel Sleegers; Patrick Cras; Nathalie Brouwers; Sally Serneels; Evelyn De Leenheir; Jean-Jacques Martin; Eugeen Vanmechelen; Christine Van Broeckhoven; Peter Paul De Deyn
No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease.
Brain : a journal of neurology 2007;130(Pt 9):2320-6.
2007: Isabelle Le Ber; Julie van der Zee; Didier Hannequin; Ilse Gijselinck; Dominique Campion; Michèle Puel; Annie Laquerrière; Tim De Pooter; Agnès Camuzat; Marleen Van den Broeck; Bruno Dubois; François Sellal; Lucette Lacomblez; Martine Vercelletto; Catherine Thomas-Antérion; Bernard-François Michel; Véronique Golfier; Mira Didic; François Salachas; Charles Duyckaerts; Marc Cruts; Patrice Verpillat; Christine Van Broeckhoven; Alexis Brice
Progranulin null mutations in both sporadic and familial frontotemporal dementia.
Human mutation 2007;28(9):846-55.
2007: Ines Dierick; Joy Irobi; Sophie Janssens; Jessie Theuns; Robin Lemmens; An Jacobs; Ellen Corsmit; Nicole Hersmus; Ludo Van Den Bosch; Wim Robberecht; Peter De Jonghe; Christine Van Broeckhoven; Vincent Timmerman
Genetic variant in the HSPB1 promoter region impairs the HSP27 stress response.
Human mutation 2007;28(8):830.
2007: M Axel Wollmer; Kristel Sleegers; Martin Ingelsson; Cezary Zekanowski; Nathalie Brouwers; Aleksandra Maruszak; Fabienne Brunner; Kim-Dung Huynh; Lena Kilander; Rose-Marie Brundin; Marie Hedlund; Vilmantas Giedraitis; Anna Glaser; Sebastiaan Engelborghs; Peter Paul De Deyn; Elisabeth Kapaki; Magdalini Tsolaki; Makrina Daniilidou; Dimitra Molyva; George P Paraskevas; Dietmar R Thal; Maria Barcikowska; Jacek Kuznicki; Lars Lannfelt; Christine Van Broeckhoven; Roger M Nitsch; Christoph Hock; Andreas Papassotiropoulos
Association study of cholesterol-related genes in Alzheimer's disease.
Neurogenetics 2007;8(3):179-88.
2007: Fan Liu; Alejandro Arias-Vásquez; Kristel Sleegers; Yurii Aulchenko; Manfred Kayser; Pascual Sanchez-Juan; Bing-Jian Feng; Aida M Bertoli Avella; John C van Swieten; Tatiana I Axenovich; Peter Heutink; Christine Van Broeckhoven; Ben A Oostra; C.M. Duijn
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population.
American journal of human genetics 2007;81(1):17-31.
2007: Julie van der Zee; Isabelle Le Ber; Sebastian Maurer-Stroh; Sebastiaan Engelborghs; Ilse Gijselinck; Agnès Camuzat; Nathalie Brouwers; Rik Vandenberghe; Kristel Sleegers; Didier Hannequin; Bart Dermaut; Joost Schymkowitz; Dominique Campion; Patrick Santens; Jean-Jacques Martin; Lucette Lacomblez; Tim De Pooter; Karin Peeters; Maria Mattheijssens; Martine Vercelletto; Marleen Van den Broeck; Marc Cruts; Peter Paul De Deyn; Frederic Rousseau; Alexis Brice; Christine Van Broeckhoven
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
Human mutation 2007;28(4):416.
2007: Cindy M de Frias; David Bunce; Ake Wahlin; Rolf Adolfsson; Kristel Sleegers; Marc Cruts; Christine Van Broeckhoven; Lars-Göran Nilsson
Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults.
The journals of gerontology. Series B, Psychological sciences and social sciences 2007;62(2):P112-8.
2007: Anna Sundström; Lars-Göran Nilsson; Marc Cruts; Rolf Adolfsson; Christine Van Broeckhoven; Lars Nyberg
Increased risk of dementia following mild head injury for carriers but not for non-carriers of the APOE epsilon4 allele.
International psychogeriatrics / IPA 2007;19(1):159-65.
2007: Stefan Weckx; Peter De Rijk; Wim Glassee; Christine Van Broeckhoven; Jurgen Del-Favero
SNPbox: web-based high-throughput primer design with an eye for repetitive sequences.
Methods in molecular biology (Clifton, N.J.) 2007;402():179-200.
2007: Bianca Van Broeck; Christine Van Broeckhoven; Samir Kumar-Singh
Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches.
Neuro-degenerative diseases 2007;4(5):349-65.
2007: Julie van der Zee; Ilse Gijselinck; Daniel Pirici; Samir Kumar-Singh; Marc Cruts; Christine Van Broeckhoven
Frontotemporal lobar degeneration with ubiquitin-positive inclusions: a molecular genetic update.
Neuro-degenerative diseases 2007;4(2-3):227-35.
2007: Samir Kumar-Singh; Christine Van Broeckhoven
Frontotemporal lobar degeneration: current concepts in the light of recent advances.
Brain pathology (Zurich, Switzerland) 2007;17(1):104-14.
2006: Marc Cruts; Samir Kumar-Singh; Christine Van Broeckhoven
Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
Current Alzheimer research 2006;3(5):485-91.
2006: Udo Rüb; Ewout R Brunt; E Petrasch-Parwez; Ludger Schöls; D Theegarten; Georg Auburger; Kay Seidel; Christian Schultz; Kristin Gierga; Henry L Paulson; Christine Van Broeckhoven; Thomas Deller; Rob A I de Vos
Degeneration of ingestion-related brainstem nuclei in spinocerebellar ataxia type 2, 3, 6 and 7.
Neuropathology and applied neurobiology 2006;32(6):635-49.
2006: Filip Van Den Eede; Dirk van West; Christine Van Broeckhoven; Stephan J Claes
Role of glucocorticoid receptor gene in vulnerability for major depression: commentary on Neigh and Nemeroff.
Trends in endocrinology and metabolism: TEM 2006;17(10):386; author reply 387.
2006: Johanna Lind; Martin Ingvar; Jonas Persson; Kristel Sleegers; Christine Van Broeckhoven; Rolf Adolfsson; Lars-Göran Nilsson; Lars Nyberg
Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon4 carriers.
Neuroreport 2006;17(16):1683-6.
2006: Alexis Elbaz; Lorene Nelson; Haydeh Payami; John Ioannidis; Brian Fiske; Grazia Annesi; Andrea Carmine Belin; Stewart A Factor; Carlo Ferrarese; Georgios M Hadjigeorgiou; Donald S Higgins; Hideshi Kawakami; Rejko Krüger; Karen Marder; Richard Mayeux; George D Mellick; John G Nutt; Beate Ritz; Ali Samii; Caroline M Tanner; Christine Van Broeckhoven; Stephen K Van Den Eeden; Karin Wirdefeldt; Cyrus Zabetian; Marie Dehem; Jennifer S Montimurro; Audrey Southwick; Richard Myers; Thomas A Trikalinos
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.
Lancet neurology 2006;5(11):917-23.
2006: Nathalie Brouwers; Kristel Sleegers; Sebastiaan Engelborghs; Veerle Bogaerts; Sally Serneels; Kenan Kamali; Ellen Corsmit; Evelyn De Leenheir; Jean-Jacques Martin; Peter Paul De Deyn; Christine Van Broeckhoven; Jessie Theuns
Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.
Brain : a journal of neurology 2006;129(Pt 11):2984-91.
2006: Kristel Sleegers; Nathalie Brouwers; Ilse Gijselinck; Jessie Theuns; Dirk Goossens; Jan Wauters; Jurgen Del-Favero; Marc Cruts; C.M. Duijn; Christine Van Broeckhoven
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.
Brain : a journal of neurology 2006;129(Pt 11):2977-83.
2006: Ann Van Den Bogaert; Kristel Sleegers; Sonia De Zutter; Lien Heyrman; Karl-Fredrik Norrback; Rolf Adolfsson; Christine Van Broeckhoven; Jurgen Del-Favero
Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.
Archives of general psychiatry 2006;63(10):1103-10.
2006: Ann Van Den Bogaert; Kristel Sleegers; Sonia De Zutter; Lien Heyrman; Karl-Fredrik Norrback; Rolf Adolfsson; Christine Van Broeckhoven; Jurgen Del-Favero
No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.
Psychiatric genetics 2006;16(5):209-12.
2006: Ilse Gijselinck; Veerle Bogaerts; Rosa Rademakers; Julie van der Zee; Christine Van Broeckhoven; Marc Cruts
Visualization of MAPT inversion on stretched chromosomes of tau-negative frontotemporal dementia patients.
Human mutation 2006;27(10):1057-9.
2006: Jessie Theuns; Els Marjaux; Mathieu Vandenbulcke; K Van Laere; Samir Kumar-Singh; G Bormans; Nathalie Brouwers; Marleen Van den Broeck; Krist'l Vennekens; Ellen Corsmit; Marc Cruts; Bart De Strooper; Christine Van Broeckhoven; Rik Vandenberghe
Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment.
Human mutation 2006;27(9):888-96.
2006: Ann Van Den Bogaert; Jurgen Del-Favero; Christine Van Broeckhoven
Major affective disorders and schizophrenia: a common molecular signature?
Human mutation 2006;27(9):833-53.
2006: Marc Cruts; Ilse Gijselinck; Julie van der Zee; Sebastiaan Engelborghs; Hans Wils; Daniel Pirici; Rosa Rademakers; Rik Vandenberghe; Bart Dermaut; Jean-Jacques Martin; C.M. Duijn; Karin Peeters; Raf Sciot; Patrick Santens; Tim De Pooter; Maria Mattheijssens; Marleen Van den Broeck; Ivy Cuijt; Krist'l Vennekens; Peter Paul De Deyn; Samir Kumar-Singh; Christine Van Broeckhoven
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
Nature 2006;442(7105):920-4.
2006: Dominique Audenaert; E Schwartz; Kristl G Claeys; Lieve R F Claes; Liesbet Deprez; Arvid Suls; Tine Van Dyck; Lieven Lagae; Christine Van Broeckhoven; R L Macdonald; Peter De Jonghe
A novel GABRG2 mutation associated with febrile seizures.
Neurology 2006;67(4):687-90.
2006: Demetrius M Maraganore; Mariza de Andrade; Alexis Elbaz; Matthew J Farrer; John Ioannidis; Rejko Krüger; Walter A Rocca; Nicole K Schneider; Timothy G Lesnick; Sarah J Lincoln; Mary Hulihan; Jan Aasly; Tetsuo Ashizawa; Marie-Christine Chartier-Harlin; Harvey Checkoway; Carlo Ferrarese; Georgios M Hadjigeorgiou; Nobutaka Hattori; Hideshi Kawakami; jean-charles lambert; Timothy Lynch; George D Mellick; Spiridon Papapetropoulos; Abbas Parsian; Aldo Quattrone; Olaf Riess; Eng-King Tan; Christine Van Broeckhoven
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.
JAMA : the journal of the American Medical Association 2006;296(6):661-70.
2006: Dimitris G Dikeos; George N Papadimitriou; Daniel Souery; Jurgen Del-Favero; Isabelle Massat; Douglas Blackwood; Sven Cichon; Eugenia G Daskalopoulou; Sladjana Ivezic; RAdka Kaneva; GEORGIA KARADIMA; Cristina Lorenzi; vihra milanova; Walter Muir; Markus M Nöthen; Lilijana Oruc; Marcella Rietschel; Alessandro Serretti; Christine Van Broeckhoven; Constantin R Soldatos; Costas N Stefanis; Julien Mendlewicz
Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study.
Psychiatric genetics 2006;16(4):169-71.
2006: Samir Kumar-Singh; Jessie Theuns; Bianca Van Broeck; Daniel Pirici; Krist'l Vennekens; Ellen Corsmit; Marc Cruts; Bart Dermaut; Rong Wang; Christine Van Broeckhoven
Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.
Human mutation 2006;27(7):686-95.
2006: Jessie Theuns; Nathalie Brouwers; Sebastiaan Engelborghs; Kristel Sleegers; Veerle Bogaerts; Ellen Corsmit; Tim De Pooter; C.M. Duijn; Peter Paul De Deyn; Christine Van Broeckhoven
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
American journal of human genetics 2006;78(6):936-46.
2006: Dominique Audenaert; Christine Van Broeckhoven; Peter De Jonghe
Genes and loci involved in febrile seizures and related epilepsy syndromes.
Human mutation 2006;27(5):391-401.
2006: Johanna Lind; Jonas Persson; Martin Ingvar; Anne Larsson; Marc Cruts; Christine Van Broeckhoven; Rolf Adolfsson; Lars Bäckman; Lars-Göran Nilsson; Karl Magnus Petersson; Lars Nyberg
Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers.
Brain : a journal of neurology 2006;129(Pt 5):1240-8.
2006: Said Ali S Al-Yahyaee; Lihadh Al-Gazali; P De Jonghe; H Al-Barwany; Mohammed Nasser Al-Kindi; E De Vriendt; Pratap R Chand; Roshan Koul; Poovathoor C Jacob; Gururaj Aithala; László Sztriha; A Parrado; Christine Van Broeckhoven; Riad Bayoumi
A novel locus for hereditary spastic paraplegia with thin corpus callosum and epilepsy.
Neurology 2006;66(8):1230-4.
2006: J Persson; J Lind; A Larsson; Martin Ingvar; Marc Cruts; Christine Van Broeckhoven; Rolf Adolfsson; Lars-Göran Nilsson; Lars Nyberg
Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?
Neurology 2006;66(7):1029-33.
2006: Julie van der Zee; Rosa Rademakers; Sebastiaan Engelborghs; Ilse Gijselinck; Veerle Bogaerts; Rik Vandenberghe; Patrick Santens; Jo Caekebeke; Tim De Pooter; Karin Peeters; Ursula Lübke; Marleen Van den Broeck; Jean-Jacques Martin; Marc Cruts; Peter Paul De Deyn; Christine Van Broeckhoven; Bart Dermaut
A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD.
Brain : a journal of neurology 2006;129(Pt 4):841-52.
2006: Johanna Lind; Anne Larsson; Jonas Persson; Martin Ingvar; Lars-Göran Nilsson; Lars Bäckman; Rolf Adolfsson; Marc Cruts; Kristel Sleegers; Christine Van Broeckhoven; Lars Nyberg
Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory.
Neuroscience letters 2006;396(1):23-7.
2006: Daniel Pirici; Rik Vandenberghe; Rosa Rademakers; Bart Dermaut; Marc Cruts; Krist'l Vennekens; Ivy Cuijt; Ursula Lübke; Chantal Ceuterick; Jean-Jacques Martin; Christine Van Broeckhoven; Samir Kumar-Singh
Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family.
Journal of neuropathology and experimental neurology 2006;65(3):289-301.
2006: Dirk van West; Filip Van Den Eede; Jurgen Del-Favero; Daniel Souery; Karl-Fredrik Norrback; C.M. Duijn; Sam Sluijs; Rolf Adolfsson; Julien Mendlewicz; Dirk Deboutte; Christine Van Broeckhoven; Stephan J Claes
Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(3):620-7.
2006: Sebastiaan Engelborghs; Bart Dermaut; Peter Mariën; Anoek Symons; Ellen Vloeberghs; Karen Maertens; Nore Somers; Johan Goeman; Rosa Rademakers; Marleen Van den Broeck; Barbara A Pickut; Marc Cruts; Christine Van Broeckhoven; Peter Paul De Deyn
Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia.
Neurobiology of aging 2006;27(2):285-92.
2006: Tine Venken; Maaike Alaerts; Rolf Adolfsson; Christine Van Broeckhoven; Jurgen Del-Favero
No association of the trace amine-associated receptor 6 with bipolar disorder in a northern Swedish population.
Psychiatric genetics 2006;16(1):1-2.
2006: Fijs W B van Leeuwen; P van Tijn; M A F Sonnemans; Barbara Hobo; D M A Mann; Christine Van Broeckhoven; Samir Kumar-Singh; Patrick Cras; Geneviève Leuba; Armand Savioz; Marion L C Maat-Schieman; Haruyasu Yamaguchi; J M Kros; Wouter Kamphorst; Elly M Hol; Rob A I de Vos; David F Fischer
Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies.
Neurology 2006;66(2 Suppl 1):S86-92.
2006: Nathalie Brouwers; Kristel Sleegers; Sebastiaan Engelborghs; Veerle Bogaerts; C.M. Duijn; Peter Paul De Deyn; Christine Van Broeckhoven; Bart Dermaut
The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years.
Neuroscience letters 2006;392(1-2):72-4.
2006: Christine Van Broeckhoven; Samir Kumar-Singh
Genetics and pathology of alpha-secretase site AbetaPP mutations in the understanding of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):389-98.
2006: Liesbet Deprez; Lieve R F Claes; Kristl G Claeys; Dominique Audenaert; Tine Van Dyck; Dirk Goossens; Wim Van Paesschen; Jurgen Del-Favero; Christine Van Broeckhoven; Peter De Jonghe
Genome-wide linkage of febrile seizures and epilepsy to the FEB4 locus at 5q14.3-q23.1 and no MASS1 mutation.
Human genetics 2006;118(5):618-25.
2005: Ann Van Den Bogaert; Sonia De Zutter; Lien Heyrman; Julien Mendlewicz; Rolf Adolfsson; Christine Van Broeckhoven; Jurgen Del-Favero
Response to Zhang et al (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major Depression. Neuron 45, 11-16.
Neuron 2005;48(5):704; author reply 705-6.
2005: Bart Dermaut; Samir Kumar-Singh; Rosa Rademakers; Jessie Theuns; Marc Cruts; Christine Van Broeckhoven
Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum.
Trends in genetics : TIG 2005;21(12):664-72.
2005: Julien Mendlewicz; Pierre Oswald; Stephan J Claes; Isabelle Massat; Daniel Souery; Christine Van Broeckhoven; Jurgen Del-Favero
Patient-control association study of substance P-related genes in unipolar and bipolar affective disorders.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2005;8(4):505-13.
2005: Dominique Audenaert; Lieve R F Claes; Kristl G Claeys; Liesbet Deprez; Tine Van Dyck; Dirk Goossens; Jurgen Del-Favero; Wim Van Paesschen; Christine Van Broeckhoven; Peter De Jonghe
A novel susceptibility locus at 2p24 for generalised epilepsy with febrile seizures plus.
Journal of medical genetics 2005;42(12):947-52.
2005: Rosa Rademakers; Stacey Melquist; Marc Cruts; Jessie Theuns; Jurgen Del-Favero; Parvoneh Poorkaj-Navas; Matt Baker; Kristel Sleegers; Richard Crook; Tim De Pooter; Samira Bel Kacem; Jennifer Adamson; Dirk Van den Bossche; Marleen Van den Broeck; Jennifer Gass; Ellen Corsmit; Peter De Rijk; Natalie Thomas; Sebastiaan Engelborghs; Michael G Heckman; Irene Litvan; Julia Crook; Peter Paul De Deyn; dennis dickson; Gerard D Schellenberg; Christine Van Broeckhoven; Michael Hutton
High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy.
Human molecular genetics 2005;14(21):3281-92.
2005: Gregor Kuhlenbäumer; Mark C Hannibal; Eva Nelis; Anja Schirmacher; Nathalie Verpoorten; Jan Meuleman; Giles D J Watts; Els De Vriendt; Peter Young; Florian Stögbauer; Hartmut Halfter; Joy Irobi; Dirk Goossens; Jurgen Del-Favero; Benjamin G Betz; Hyun Hor; Gerhard Kurlemann; Thomas D Bird; Eila Airaksinen; Tarja Mononen; Adolfo Pou Serradell; José M Prats; Christine Van Broeckhoven; Peter De Jonghe; Vincent Timmerman; E Bernd Ringelstein; Phillip F Chance
Mutations in SEPT9 cause hereditary neuralgic amyotrophy.
Nature genetics 2005;37(10):1044-6.
2005: Rosa Rademakers; Marc Cruts; Kristel Sleegers; Bart Dermaut; Jessie Theuns; Yurii Aulchenko; Stefan Weckx; Tim De Pooter; Marleen Van den Broeck; Ellen Corsmit; Peter De Rijk; Jurgen Del-Favero; John C van Swieten; C.M. Duijn; Christine Van Broeckhoven
Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample.
American journal of human genetics 2005;77(4):643-52.
2005: George N Papadimitriou; Daniel Souery; O Lipp; Isabelle Massat; B Mahieu; Christine Van Broeckhoven; Julien Mendlewicz
In search of anticipation in unipolar affective disorder.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2005;15(5):511-6.
2005: Pierre Oswald; Jurgen Del-Favero; Isabelle Massat; Daniel Souery; Stephan J Claes; Christine Van Broeckhoven; Julien Mendlewicz
No implication of brain-derived neurotrophic factor (BDNF) gene in unipolar affective disorder: evidence from Belgian first and replication patient-control studies.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2005;15(5):491-5.
2005: Samir Kumar-Singh; Daniel Pirici; Eileen McGowan; Sally Serneels; Chantal Ceuterick; John Hardy; karen duff; dennis dickson; Christine Van Broeckhoven
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.
The American journal of pathology 2005;167(2):527-43.
2005: Rosa Rademakers; Kristel Sleegers; Jessie Theuns; Marleen Van den Broeck; Samira Bel Kacem; Lars-Göran Nilsson; Rolf Adolfsson; C.M. Duijn; Christine Van Broeckhoven; Marc Cruts
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.
Neurobiology of aging 2005;26(8):1145-51.
2005: Marc Cruts; Rosa Rademakers; Ilse Gijselinck; Julie van der Zee; Bart Dermaut; Tim De Pooter; Peter De Rijk; Jurgen Del-Favero; Christine Van Broeckhoven
Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region.
Human molecular genetics 2005;14(13):1753-62.
2005: Filip Van Den Eede; Christine Van Broeckhoven; Stephan J Claes
Corticotropin-releasing factor-binding protein, stress and major depression.
Ageing research reviews 2005;4(2):213-39.
2005: Sandra López León; Esther A Croes; Fakhredin A Sayed-Tabatabaei; Stephan Claes; Christine Van Broeckhoven; C.M. Duijn
The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: a meta-analysis.
Biological psychiatry 2005;57(9):999-1003.
2005: Stefan Weckx; Jurgen Del-Favero; Rosa Rademakers; Lieve R F Claes; Marc Cruts; Peter De Jonghe; Christine Van Broeckhoven; Peter De Rijk
novoSNP, a novel computational tool for sequence variation discovery.
Genome research 2005;15(3):436-42.
2005: Tine Venken; Stephan J Claes; Sam Sluijs; Andrew D Paterson; C.M. Duijn; Rolf Adolfsson; Jurgen Del-Favero; Christine Van Broeckhoven
Genomewide scan for affective disorder susceptibility Loci in families of a northern Swedish isolated population.
American journal of human genetics 2005;76(2):237-48.
2005: Stefan Weckx; Peter De Rijk; Christine Van Broeckhoven; Jurgen Del-Favero
SNPbox: a modular software package for large-scale primer design.
Bioinformatics (Oxford, England) 2005;21(3):385-7.
2004: Lieve R F Claes; Berten Ceulemans; Dominique Audenaert; Liesbet Deprez; A Jansen; D Hasaerts; Stefan Weckx; Kristl G Claeys; Jurgen Del-Favero; Christine Van Broeckhoven; Peter De Jonghe
De novo KCNQ2 mutations in patients with benign neonatal seizures.
Neurology 2004;63(11):2155-8.
2004: Tischa J M van der Cammen; Esther A Croes; Bart Dermaut; Marie-Claire de Jager; Marc Cruts; Christine Van Broeckhoven; C.M. Duijn
Genetic testing has no place as a routine diagnostic test in sporadic and familial cases of Alzheimer's disease.
Journal of the American Geriatrics Society 2004;52(12):2110-3.
2004: Gert Van Goethem; Petri Luoma; Maria T Rantamäki; A Al Memar; Seppo Kaakkola; Peter Hackman; Ralf Krahe; Ann Löfgren; Jean-Jacques Martin; Peter De Jonghe; Anu Suomalainen; Bjarne Udd; Christine Van Broeckhoven
POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement.
Neurology 2004;63(7):1251-7.
2004: Philippe Pals; Sarah J Lincoln; Jonathan Manning; Michael G Heckman; Lisa Skipper; Mary Hulihan; Marleen Van den Broeck; Tim De Pooter; Patrick Cras; Julia Crook; Christine Van Broeckhoven; Matthew J Farrer
alpha-Synuclein promoter confers susceptibility to Parkinson's disease.
Annals of neurology 2004;56(4):591-5.
2004: Rosa Rademakers; Marc Cruts; Christine Van Broeckhoven
The role of tau (MAPT) in frontotemporal dementia and related tauopathies.
Human mutation 2004;24(4):277-95.
2004: Olaf Ansorge; Paola Giunti; Andrej Michalik; Christine Van Broeckhoven; Brian Harding; Nicholas W Wood; Francesco Scaravilli
Ataxin-7 aggregation and ubiquitination in infantile SCA7 with 180 CAG repeats.
Annals of neurology 2004;56(3):448-52.
2004: Lieve R F Claes; Dominique Audenaert; Liesbet Deprez; Wim Van Paesschen; C Depondt; Dirk Goossens; Jurgen Del-Favero; Christine Van Broeckhoven; Peter De Jonghe
Novel locus on chromosome 12q22-q23.3 responsible for familial temporal lobe epilepsy associated with febrile seizures.
Journal of medical genetics 2004;41(9):710-4.
2004: Pierre Oswald; Jurgen Del-Favero; Isabelle Massat; Daniel Souery; Stephan J Claes; Christine Van Broeckhoven; Julien Mendlewicz
Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;129B(1):34-5.
2004: Esther A Croes; Jessie Theuns; Jeanine J Houwing-Duistermaat; Bart Dermaut; Kristel Sleegers; Gerwin Roks; Marleen Van den Broeck; B van Harten; John C van Swieten; Marc Cruts; Christine Van Broeckhoven; C.M. Duijn
Octapeptide repeat insertions in the prion protein gene and early onset dementia.
Journal of neurology, neurosurgery, and psychiatry 2004;75(8):1166-70.
2004: Seppo Helisalmi; Bart Dermaut; Mikko Hiltunen; Arto Mannermaa; Marleen Van den Broeck; Maarit Lehtovirta; Anne Maria Koivisto; Susan Iivonen; Marc Cruts; Hilkka Soininen; Christine Van Broeckhoven
Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.
Neurology 2004;63(1):173-5.
2004: Stefan Weckx; Peter De Rijk; Christine Van Broeckhoven; Jurgen Del-Favero
SNPbox: web-based high-throughput primer design from gene to genome.
Nucleic acids research 2004;32(Web Server issue):W170-2.
2004: Julien Mendlewicz; Daniel Souery; Jurgen Del-Favero; Isabelle Massat; Kerstin Lindblad; Christer Engström; Dirk Van den Bossche; Rolf Adolfsson; Martin Schalling; Christine Van Broeckhoven
Expanded RED products and loci containing CAG/CTG repeats on chromosome 17 (ERDA1) and chromosome 18 (CTG18.1) in trans-generational pairs with bipolar affective disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;128B(1):71-5.
2004: Kristel Sleegers; Gerwin Roks; Jessie Theuns; Yurii Aulchenko; Rosa Rademakers; Marc Cruts; Willem A van Gool; Christine Van Broeckhoven; Peter Heutink; Ben A Oostra; John C van Swieten; C.M. Duijn
Familial clustering and genetic risk for dementia in a genetically isolated Dutch population.
Brain : a journal of neurology 2004;127(Pt 7):1641-9.
2004: Gregor Kuhlenbäumer; Peter Lüdemann; Anja Schirmacher; Els De Vriendt; Gert Hünermund; Peter Young; M Hund-Georgiadis; Gerhard Schuierer; H Möller; E Bernd Ringelstein; Christine Van Broeckhoven; Vincent Timmerman; Florian Stögbauer
Autosomal dominant striatal degeneration (ADSD): clinical description and mapping to 5q13-5q14.
Neurology 2004;62(12):2203-8.
2004: Anna Sundström; Petter Marklund; Lars-Göran Nilsson; Marc Cruts; Rolf Adolfsson; Christine Van Broeckhoven; Lars Nyberg
APOE influences on neuropsychological function after mild head injury: within-person comparisons.
Neurology 2004;62(11):1963-6.
2004: Stefan Weckx; Peter De Rijk; Christine Van Broeckhoven; Jurgen Del-Favero
SSHSuite: an integrated software package for analysis of large-scale suppression subtractive hybridization data.
BioTechniques 2004;36(6):1043-5.
2004: Andrej Michalik; Christine Van Broeckhoven
Proteasome degrades soluble expanded polyglutamine completely and efficiently.
Neurobiology of disease 2004;16(1):202-11.
2004: Joy Irobi; Katrien Van Impe; Pavel Seeman; Albena Jordanova; Ines Dierick; Nathalie Verpoorten; Andrej Michalik; Els De Vriendt; An Jacobs; Veerle Van Gerwen; Krist'l Vennekens; Radim Mazanec; Ivailo Tournev; David Hilton-Jones; Kevin Talbot; Ivo Kremensky; Ludo Van Den Bosch; Wim Robberecht; Joël Van Vandekerckhove; Christine Van Broeckhoven; Jan Gettemans; Peter De Jonghe; Vincent Timmerman
Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy.
Nature genetics 2004;36(6):597-601.
2004: Bart Dermaut; Samir Kumar-Singh; Sebastiaan Engelborghs; Jessie Theuns; Rosa Rademakers; Jos Saerens; Barbara A Pickut; Karin Peeters; Marleen Van den Broeck; Krist'l Vennekens; Stephan J Claes; Marc Cruts; Patrick Cras; Jean-Jacques Martin; Christine Van Broeckhoven; Peter Paul De Deyn
A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques.
Annals of neurology 2004;55(5):617-26.
2004: Esther A Croes; Behrooz Alizadeh; Aida M Bertoli Avella; Tessa Rademaker-Havinga; Jeannette Vergeer-Drop; Bart Dermaut; Jeanine J Houwing-Duistermaat; Dorothee P W M Wientjens; Albert Hofman; Christine Van Broeckhoven; C.M. Duijn
Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease.
European journal of human genetics : EJHG 2004;12(5):389-94.
2004: Julien Mendlewicz; Isabelle Massat; Daniel Souery; Jurgen Del-Favero; Lilijana Oruc; Markus M Nöthen; Douglas Blackwood; Walter Muir; Sharon Battersby; Bernard Lerer; Ronnen Segman; RAdka Kaneva; Alessandro Serretti; Roberta Lilli; Cristina Lorenzi; Miro Jakovljevic; Sladana Ivezic; Marcella Rietschel; vihra milanova; Christine Van Broeckhoven
Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study.
European journal of human genetics : EJHG 2004;12(5):377-82.
2004: A J C Slooter; Marc Cruts; Albert Hofman; Peter J Koudstaal; Deirdre A M van der Kuip; Maria A J de Ridder; Jacqueline C M Witteman; Monique Breteler; Christine Van Broeckhoven; C.M. Duijn
The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study.
Neurology 2004;62(7):1196-8.
2004: Dirk van West; Jurgen Del-Favero; Yurii Aulchenko; Pierre Oswald; Daniel Souery; Thomas Forsgren; Sam Sluijs; Samira Bel Kacem; Rolf Adolfsson; Julien Mendlewicz; C.M. Duijn; Dirk Deboutte; Christine Van Broeckhoven; Stephan J Claes
A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression.
Molecular psychiatry 2004;9(3):287-92.
2004: Rosa Rademakers; Marleen Van den Broeck; Kristel Sleegers; C.M. Duijn; Christine Van Broeckhoven; Marc Cruts
Absence of pathogenic mutations in presenilin homologue 2 in a conclusively 17-linked tau-negative dementia family.
Neurogenetics 2004;5(1):79-80.
2004: Sjoerd Wanrooij; Petri Luoma; Gert Van Goethem; Christine Van Broeckhoven; Anu Suomalainen; Johannes N Spelbrink
Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA.
Nucleic acids research 2004;32(10):3053-64.
2004: A Michalik; J-J Martin; Christine Van Broeckhoven
Spinocerebellar ataxia type 7 associated with pigmentary retinal dystrophy.
European journal of human genetics : EJHG 2004;12(1):2-15.
2003: Gert Van Goethem; Rudy Mercelis; Ann Löfgren; S Seneca; Chantal Ceuterick; Jean-Jacques Martin; Christine Van Broeckhoven
Patient homozygous for a recessive POLG mutation presents with features of MERRF.
Neurology 2003;61(12):1811-3.
2003: Marjolijn Bornebroek; Chris De Jonghe; Joost Haan; Samir Kumar-Singh; Steven G Younkin; Raymund A C Roos; Christine Van Broeckhoven
Hereditary cerebral hemorrhage with amyloidosis Dutch type (AbetaPP 693): decreased plasma amyloid-beta 42 concentration.
Neurobiology of disease 2003;14(3):619-23.
2003: George N Papadimitriou; Dimitris G Dikeos; Daniel Souery; Jurgen Del-Favero; Isabelle Massat; Dimitrios Avramopoulos; Sylvie Blairy; Sven Cichon; Sladjana Ivezic; RAdka Kaneva; GEORGIA KARADIMA; Roberta Lilli; vihra milanova; Markus M Nöthen; Lilijana Oruc; Marcella Rietschel; Alessandro Serretti; Christine Van Broeckhoven; Costas N Stefanis; Julien Mendlewicz
Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case-control study.
Psychiatric genetics 2003;13(4):211-20.
2003: Marc Cruts; Bart Dermaut; Rosa Rademakers; Marleen Van den Broeck; Florian Stögbauer; Christine Van Broeckhoven
Novel APP mutation V715A associated with presenile Alzheimer's disease in a German family.
Journal of neurology 2003;250(11):1374-5.
2003: Stephan J Claes; Sandra M Villafuerte; Thomas Forsgren; Sam Sluijs; Jurgen Del-Favero; Rolf Adolfsson; Christine Van Broeckhoven
The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden.
Biological psychiatry 2003;54(9):867-72.
2003: Rosa Rademakers; Bart Dermaut; Karin Peeters; Marc Cruts; Peter Heutink; Alison Goate; Christine Van Broeckhoven
Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe.
Human mutation 2003;22(5):409-11.
2003: Omar Nyabi; Mostafa Bentahir; Katrien Horré; An Herreman; Numa Gottardi-Littell; Christine Van Broeckhoven; Pascal Merchiers; Kurt Spittaels; Willem ANNAERT; Bart De Strooper
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.
The Journal of biological chemistry 2003;278(44):43430-6.
2003: Andrej Michalik; Christine Van Broeckhoven
Pathogenesis of polyglutamine disorders: aggregation revisited.
Human molecular genetics 2003;12 Spec No 2():R173-86.
2003: S Van Gestel; Christine Van Broeckhoven
Genetics of personality: are we making progress?
Molecular psychiatry 2003;8(10):840-52.
2003: Tom Van Agtmael; Susan M Forrest; Jurgen Del-Favero; Christine Van Broeckhoven; Robert Williamson
Parametric and nonparametric genome scan analyses for human handedness.
European journal of human genetics : EJHG 2003;11(10):779-83.
2003: Pierre Oswald; Daniel Souery; Isabelle Massat; Jurgen Del-Favero; Sylvie Linotte; George N Papadimitriou; Dimitris G Dikeos; RAdka Kaneva; vihra milanova; Lilijana Oruc; Sladana Ivezic; Alessandro Serretti; Roberta Lilli; Christine Van Broeckhoven; Julien Mendlewicz
Lack of association between the 5HT2A receptor polymorphism (T102C) and unipolar affective disorder in a multicentric European study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2003;13(5):365-8.
2003: Dominique Audenaert; Lieve R F Claes; Berten Ceulemans; Ann Löfgren; Christine Van Broeckhoven; Peter De Jonghe
A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy.
Neurology 2003;61(6):854-6.
2003: Esther A Croes; Bart Dermaut; Jeanine J Houwing-Duistermaat; Marleen Van den Broeck; Marc Cruts; Monique Breteler; Albert Hofman; Christine Van Broeckhoven; C.M. Duijn
Early cognitive decline is associated with prion protein codon 129 polymorphism.
Annals of neurology 2003;54(2):275-6.
2003: Sebastiaan Engelborghs; Bart Dermaut; Johan Goeman; Jos Saerens; Peter Mariën; Barbara A Pickut; Marleen Van den Broeck; Sally Serneels; Marc Cruts; Christine Van Broeckhoven; Peter Paul De Deyn
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects.
Journal of neurology, neurosurgery, and psychiatry 2003;74(8):1148-51.
2003: Gert Van Goethem; Ann Löfgren; Bart Dermaut; Chantal Ceuterick; Jean-Jacques Martin; Christine Van Broeckhoven
Digenic progressive external ophthalmoplegia in a sporadic patient: recessive mutations in POLG and C10orf2/Twinkle.
Human mutation 2003;22(2):175-6.
2003: Diether Lambrechts; Erik Storkebaum; Masafumi Morimoto; Jurgen Del-Favero; Frederik Desmet; Stefan L Marklund; Sabine Wyns; Vincent Thijs; Jörgen Andersson; Ingrid van Marion; Ammar Al-Chalabi; Stephanie Bornes; Rhiannon Musson; Valerie Hansen; Lars Beckman; Rolf Adolfsson; Hardev Singh Pall; Hervé Prats; Severine Vermeire; Paul Rutgeerts; Shigehiro Katayama; Takuya Awata; Nigel Leigh; Loïc Lang-Lazdunski; Mieke Dewerchin; Christopher Shaw; Lieve Moons; Robert Francois Vlietinck; Karen E Morrison; Wim Robberecht; Christine Van Broeckhoven; Désiré Collen; Peter M Andersen; Peter Carmeliet
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death.
Nature genetics 2003;34(4):383-94.
2003: Carolina Johansson; Matthäus Willeit; Robert D Levitan; Timo Partonen; Christina Smedh; Jurgen Del-Favero; Samira Bel Kacem; Nicole Praschak-Rieder; Alexander Neumeister; Mario Masellis; Vincenzo S Basile; Peter Zill; B Bondy; Tiina Paunio; Siegfried Kasper; Christine Van Broeckhoven; Lars-Göran Nilsson; Raymond Lam; Martin Schalling; Rolf Adolfsson
The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality.
Psychological medicine 2003;33(5):785-92.
2003: Gert Van Goethem; Marianne Schwartz; Ann Löfgren; Bart Dermaut; Christine Van Broeckhoven; John Vissing
Novel POLG mutations in progressive external ophthalmoplegia mimicking mitochondrial neurogastrointestinal encephalomyopathy.
European journal of human genetics : EJHG 2003;11(7):547-9.
2003: Ricardo Segurado; Sevilla D Detera-Wadleigh; Douglas F Levinson; Cathryn M Lewis; Michael Gill; John I Nurnberger; Nick Craddock; J. Raymond DePaulo; Miron Baron; Elliot S Gershon; Jenny Ekholm; Sven Cichon; Gustavo Turecki; Stephan Claes; John R Kelsoe; Peter R Schofield; Renee F Badenhop; J Morissette; Hilary Coon; Douglas Blackwood; L Alison McInnes; Tatiana Foroud; Howard J Edenberg; Theodore Reich; John P Rice; Alison Goate; Melvin G McInnis; Francis McMajon; Judith A Badner; Lynn R Goldin; Phil Bennett; Virginia L Willour; Peter P Zandi; Jianjun Liu; Conrad Gilliam; Suh-Hang Juo; Wade H Berrettini; Takeo Yoshikawa; Leena Peltonen; Jouko Lönnqvist; Markus M Nöthen; Johannes Schumacher; Christine Windemuth; Marcella Rietschel; Peter Propping; Wolfgang Maier; Martin Alda; Paul Grof; Guy A Rouleau; Jurgen Del-Favero; Christine Van Broeckhoven; Julien Mendlewicz; Rolf Adolfsson; M Anne Spence; Hermann Luebbert; Linda J Adams; Jennifer A Donald; Philip B Mitchell; Nicholas Barden; Eric Shink; William Byerley; Walter Muir; Peter M Visscher; Stuart Macgregor; Hugh Gurling; Gursharan Kalsi; Andrew McQuillin; Michael Escamilla; Victor I Reus; Pedro Leon; Nelson B Freimer; Henrik Ewald; Torben A Kruse; Ole Mors; Uppala Radhakrishna; Jean-Louis Blouin; Stylianos Antonarakis; Nurten Akarsu
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.
American journal of human genetics 2003;73(1):49-62.
2003: Rosa Rademakers; Marc Cruts; Christine Van Broeckhoven
Genetics of early-onset Alzheimer dementia.
TheScientificWorldJournal 2003;3():497-519.
2003: Lieve R F Claes; Berten Ceulemans; Dominique Audenaert; Katrien Smets; Ann Löfgren; Jurgen Del-Favero; Sirpa Ala-Mello; Lina Basel-Vanagaite; Barbara Plecko; Salmo Raskin; Paul Thiry; Nicole I Wolf; Christine Van Broeckhoven; Peter De Jonghe
De novo SCN1A mutations are a major cause of severe myoclonic epilepsy of infancy.
Human mutation 2003;21(6):615-21.
2003: Jessie Theuns; Jacques Remacle; Richard Killick; Ellen Corsmit; Krist'l Vennekens; Danny Huylebroeck; Marc Cruts; Christine Van Broeckhoven
Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression.
Human molecular genetics 2003;12(8):869-77.
2003: Bart Dermaut; Esther A Croes; Rosa Rademakers; Marleen Van den Broeck; Marc Cruts; Albert Hofman; C.M. Duijn; Christine Van Broeckhoven
PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.
Annals of neurology 2003;53(3):409-12.
2003: Gert Van Goethem; Jean-Jacques Martin; Bart Dermaut; Ann Löfgren; A Wibail; D Ververken; P Tack; I Dehaene; M Van Zandijcke; M Moonen; Chantal Ceuterick; Peter De Jonghe; Christine Van Broeckhoven
Recessive POLG mutations presenting with sensory and ataxic neuropathy in compound heterozygote patients with progressive external ophthalmoplegia.
Neuromuscular disorders : NMD 2003;13(2):133-42.
2003: Gert Van Goethem; Jean-Jacques Martin; Christine Van Broeckhoven
Progressive external ophthalmoplegia characterized by multiple deletions of mitochondrial DNA: unraveling the pathogenesis of human mitochondrial DNA instability and the initiation of a genetic classification.
Neuromolecular medicine 2003;3(3):129-46.
2003: Dirk Goossens; S Van Gestel; Stephan J Claes; Peter De Rijk; Daniel Souery; Isabelle Massat; Dirk Van den Bossche; Hubert Backhovens; Julien Mendlewicz; Christine Van Broeckhoven; Jurgen Del-Favero
A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder.
Molecular psychiatry 2003;8(1):83-9.
2002: Eva Nelis; S Erdem; P Y K Van Den Bergh; M-C Belpaire-Dethiou; Chantal Ceuterick; Veerle Van Gerwen; Ana Cuesta; Laia Pedrola; Francesc Palau; A A W M Gabreëls-Festen; Christine Verellen; E Tan; Mehmet Demirci; Christine Van Broeckhoven; Peter De Jonghe; H Topaloglu; Vincent Timmerman
Mutations in GDAP1: autosomal recessive CMT with demyelination and axonopathy.
Neurology 2002;59(12):1865-72.
2002: Arif B Ekici; Sevinc Oezbey; Christina Fuchs; Eva Nelis; Christine Van Broeckhoven; Melitta Schachner; Bernd Rautenstrauss
Tracing myelin protein zero (P0) in vivo by construction of P0-GFP fusion proteins.
BMC cell biology 2002;3():29.
2002: Samir Kumar-Singh; Ann Julliams; Rony Nuydens; Chantal Ceuterick; Christine Labeur; Sally Serneels; Krist'l Vennekens; Peter Van Osta; Hugo Geerts; Bart De Strooper; Christine Van Broeckhoven
In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity.
Neurobiology of disease 2002;11(2):330-40.
2002: Eva Nelis; Sevim Erdem; Ersin Tan; Ann Löfgren; Chantal Ceuterick; Peter De Jonghe; Christine Van Broeckhoven; Vincent Timmerman; Haluk Topaloglu
A novel homozygous missense mutation in the myotubularin-related protein 2 gene associated with recessive Charcot-Marie-Tooth disease with irregularly folded myelin sheaths.
Neuromuscular disorders : NMD 2002;12(9):869-73.
2002: Peter Ponsaerts; Glenn A Van den Bosch; Nathalie Cools; Ann Van Driessche; Griet Nijs; Marc Lenjou; Filip Lardon; Christine Van Broeckhoven; Dirk R Van Bockstaele; Zwi N Berneman; V F I Van Tendeloo
Messenger RNA electroporation of human monocytes, followed by rapid in vitro differentiation, leads to highly stimulatory antigen-loaded mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):1669-75.
2002: Samir Kumar-Singh; Patrick Cras; Rong Wang; John M Kros; John C van Swieten; Ursula Lübke; Chantal Ceuterick; Sally Serneels; Krist'l Vennekens; Jean-Pierre Timmermans; Eric Van Marck; Jean-Jacques Martin; C.M. Duijn; Christine Van Broeckhoven
Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric.
The American journal of pathology 2002;161(2):507-20.
2002: Gerwin Roks; Marc Cruts; Jeanine J Houwing-Duistermaat; Bart Dermaut; Sally Serneels; L M Havekes; Albert Hofman; Monique Breteler; Christine Van Broeckhoven; C.M. Duijn
Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.
American journal of medical genetics 2002;114(5):570-3.
2002: Peter Ponsaerts; V F I Van Tendeloo; Nathalie Cools; Ann Van Driessche; Filip Lardon; Griet Nijs; Marc Lenjou; Gerhard Mertens; Christine Van Broeckhoven; Dirk R Van Bockstaele; Zwi N Berneman
mRNA-electroporated mature dendritic cells retain transgene expression, phenotypical properties and stimulatory capacity after cryopreservation.
Leukemia 2002;16(7):1324-30.
2002: Joy Irobi; Eva Nelis; Kristien Verhoeven; Els De Vriendt; Ines Dierick; Peter De Jonghe; Christine Van Broeckhoven; Vincent Timmerman
Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3.
Journal of the peripheral nervous system : JPNS 2002;7(2):87-95.
2002: S M Rosso; Gerwin Roks; Marc Cruts; Christine Van Broeckhoven; Peter Heutink; C.M. Duijn; John C van Swieten
Apolipoprotein E4 in the temporal variant of frontotemporal dementia.
Journal of neurology, neurosurgery, and psychiatry 2002;72(6):820.
2002: Bart Dermaut; Jessie Theuns; Kristel Sleegers; Hiroshi Hasegawa; Marleen Van den Broeck; Krist'l Vennekens; Ellen Corsmit; Peter St George-Hyslop; Marc Cruts; C.M. Duijn; Christine Van Broeckhoven
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample.
American journal of human genetics 2002;70(6):1568-74.
2002: Jurgen Del-Favero; Sofie Van Gestel; Anders D Børglum; Walter Muir; Henrik Ewald; Ole Mors; Sladana Ivezic; Lilijana Oruc; Rolf Adolfsson; Douglas Blackwood; Torben Kruse; Julien Mendlewicz; Martin Schalling; Christine Van Broeckhoven
European combined analysis of the CTG18.1 and the ERDA1 CAG/CTG repeats in bipolar disorder.
European journal of human genetics : EJHG 2002;10(4):276-80.
2002: Sandra M Villafuerte; Jurgen Del-Favero; Rolf Adolfsson; Daniel Souery; Isabelle Massat; Julien Mendlewicz; Christine Van Broeckhoven; Stephan J Claes
Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression.
American journal of medical genetics 2002;114(2):222-6.
2002: Isabelle Massat; Daniel Souery; Jurgen Del-Favero; Sofie Van Gestel; Alessandro Serretti; Fabio Macciardi; Enrico Smeraldi; RAdka Kaneva; Rolf Adolfsson; Peter O Nylander; Douglas Blackwood; Walter Muir; George N Papadimitriou; Dimitris Dikeos; Lilijana Oruc; Ronnen Segman; Sladjana Ivezic; Harold Aschauer; Manfred Ackenheil; S Fuchshuber; Henrik Dam; Miro Jakovljevic; Leena Peltonen; Christiane Hilger; François Hentges; Luc Staner; Vihra Milanova; Elena Jazin; Bernard Lerer; Christine Van Broeckhoven; Julien Mendlewicz
Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders.
American journal of medical genetics 2002;114(2):177-85.
2002: Gert Van Goethem; Jean-Jacques Martin; Christine Van Broeckhoven
Progressive external ophthalmoplegia and multiple mitochondrial DNA deletions.
Acta neurologica Belgica 2002;102(1):39-42.
2002: Pieter Jelle Visser; Frans Verhey; Philip scheltens; Marc Cruts; Rudolf W H M Ponds; Christine Van Broeckhoven; Jelle Jolles
Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjects.
Journal of neurology 2002;249(3):312-9.
2002: Rosa Rademakers; Marc Cruts; Bart Dermaut; Kristel Sleegers; S M Rosso; Marleen Van den Broeck; Hubert Backhovens; John C van Swieten; C.M. Duijn; Christine Van Broeckhoven
Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval.
Molecular psychiatry 2002;7(10):1064-74.
2002: S Van Gestel; Thomas Forsgren; Stephan J Claes; Jurgen Del-Favero; C.M. Duijn; Sam Sluijs; Lars-Göran Nilsson; Rolf Adolfsson; Christine Van Broeckhoven
Epistatic effect of genes from the dopamine and serotonin systems on the temperament traits of novelty seeking and harm avoidance.
Molecular psychiatry 2002;7(5):448-50.
2002: Isabelle Massat; Daniel Souery; Jurgen Del-Favero; Lilijana Oruc; M M Noethen; Douglas Blackwood; M Thomson; Walter Muir; George N Papadimitriou; Dimitris G Dikeos; RAdka Kaneva; Alessandro Serretti; Roberta Lilli; Enrico Smeraldi; Miro Jakovljevic; V Folnegovic; Marcella Rietschel; vihra milanova; F Valente; Christine Van Broeckhoven; Julien Mendlewicz
Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study.
Molecular psychiatry 2002;7(2):201-7.
2001: Bart Dermaut; Samir Kumar-Singh; Chris De Jonghe; Marc Cruts; Ann Löfgren; Ursula Lübke; Patrick Cras; René Dom; Peter Paul De Deyn; Jean-Jacques Martin; Christine Van Broeckhoven
Cerebral amyloid angiopathy is a pathogenic lesion in Alzheimer's disease due to a novel presenilin 1 mutation.
Brain : a journal of neurology 2001;124(Pt 12):2383-92.
2001: A Matilla; Carlos Gorbea; David D Einum; J Townsend; A Michalik; Christine Van Broeckhoven; Christopher C Jensen; K J Murphy; Louis J Ptácek; Ying-Hui Fu
Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex.
Human molecular genetics 2001;10(24):2821-31.
2001: Marc Cruts; Bart Dermaut; Rosa Rademakers; Gerwin Roks; Marleen Van den Broeck; G Munteanu; C.M. Duijn; Christine Van Broeckhoven
Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease.
Neuroscience letters 2001;313(1-2):105-7.
2001: Bart Van Everbroeck; Esther A Croes; Philippe Pals; Bart Dermaut; G Jansen; C.M. Duijn; Marc Cruts; Christine Van Broeckhoven; Jean-Jacques Martin; Patrick Cras
Influence of the prion protein and the apolipoprotein E genotype on the Creutzfeldt-Jakob Disease phenotype.
Neuroscience letters 2001;313(1-2):69-72.
2001: Joy Irobi; Eva Nelis; Jan Meuleman; Katrien Venken; Peter De Jonghe; Christine Van Broeckhoven; Vincent Timmerman
Exclusion of 5 functional candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3.
Annals of human genetics 2001;65(Pt 6):517-29.
2001: Bart Dermaut; Gerwin Roks; Jessie Theuns; Rosa Rademakers; Jeanine J Houwing-Duistermaat; Sally Serneels; Albert Hofman; Monique Breteler; Marc Cruts; Christine Van Broeckhoven; C.M. Duijn
Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's disease.
Journal of neurology 2001;248(11):935-9.
2001: Dirk Goossens; Jurgen Del-Favero; Christine Van Broeckhoven
Trinucleotide repeat expansions: do they contribute to bipolar disorder?
Brain research bulletin 2001;56(3-4):243-57.
2001: Anne M Cataldo; G. William Rebeck; B Ghetri; Christine M Hulette; Carol F Lippa; Christine Van Broeckhoven; C.M. Duijn; Patrick cras; Nenad Bogdanovic; Thomas D Bird; Corrinne M Peterhoff; Ralph A. Nixon
Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders.
Annals of neurology 2001;50(5):661-5.
2001: Gregor Kuhlenbäumer; Jan Meuleman; Peter De Jonghe; B Falck; Peter Young; Gert Hünermund; Christine Van Broeckhoven; Vincent Timmerman; Florian Stögbauer
Hereditary Neuralgic Amyotrophy (HNA) is genetically heterogeneous.
Journal of neurology 2001;248(10):861-5.
2001: Hiroto Fujigasaki; J J Martin; P P De Deyn; Agnès Camuzat; D Deffond; Giovanni Stevanin; Bart Dermaut; Christine Van Broeckhoven; Alexandra Dürr; Alexis Brice
CAG repeat expansion in the TATA box-binding protein gene causes autosomal dominant cerebellar ataxia.
Brain : a journal of neurology 2001;124(Pt 10):1939-47.
2001: D Arango; Marc Cruts; O Torres; Hubert Backhovens; M L Serrano; E Villareal; P Montañes; D Matallana; C Cano; Christine Van Broeckhoven; Martine Jacquier
Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia.
American journal of medical genetics 2001;103(2):138-43.
2001: Isabelle Massat; Daniel Souery; Jurgen Del-Favero; Lilijana Oruc; Miro Jakovljevic; V Folnegovic; Rolf Adolfsson; RAdka Kaneva; George N Papadimitriou; Dimitris G Dikeos; Elena Jazin; vihra milanova; Christine Van Broeckhoven; Julien Mendlewicz
Lack of association between GABRA3 and unipolar affective disorder: a multicentre study.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2001;4(3):273-8.
2001: A J C Slooter; Marc Cruts; Christine Van Broeckhoven; Albert Hofman; C M van Duijin
Apolipoprotein E and longevity: the Rotterdam Study.
Journal of the American Geriatrics Society 2001;49(9):1258-9.
2001: A J C Slooter; Michiel Bots; L M Havekes; Antonio Iglesias Del Sol; Marc Cruts; Diederick Grobbee; Albert Hofman; Christine Van Broeckhoven; Jacqueline C M Witteman; C.M. Duijn
Apolipoprotein E and carotid artery atherosclerosis: the Rotterdam study.
Stroke; a journal of cerebral circulation 2001;32(9):1947-52.
2001: Bernard Lerer; Fabio Macciardi; Ronnen Segman; Rolf Adolfsson; Douglas Blackwood; Sylvie Blairy; Jurgen Del-Favero; Dimitris G Dikeos; RAdka Kaneva; Roberta Lilli; Isabelle Massat; vihra milanova; Walter Muir; M Noethen; Lilijana Oruc; T Petrova; George N Papadimitriou; Marcella Rietschel; Alessandro Serretti; Daniel Souery; S Van Gestel; Christine Van Broeckhoven; Julien Mendlewicz
Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder.
Molecular psychiatry 2001;6(5):579-85.
2001: S M Ismailov; Valeriy Fedotov; Elena L Dadali; Alexander V Polyakov; Christine Van Broeckhoven; V I Ivanov; Peter De Jonghe; Vincent Timmerman; Oleg V Evgrafov
A new locus for autosomal dominant Charcot-Marie-Tooth disease type 2 (CMT2F) maps to chromosome 7q11-q21.
European journal of human genetics : EJHG 2001;9(8):646-50.
2001: Andrej Michalik; A Kazantsev; Christine Van Broeckhoven
Method to introduce stable, expanded, polyglutamine-encoding CAG/CAA trinucleotide repeats into CAG repeat-containing genes.
BioTechniques 2001;31(2):250-2, 254.
2001: Chris De Jonghe; Cary Esselens; Samir Kumar-Singh; Katleen Craessaerts; Sally Serneels; F Checler; Willem ANNAERT; Christine Van Broeckhoven; Bart De Strooper
Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.
Human molecular genetics 2001;10(16):1665-71.
2001: Gerwin Roks; Marc Cruts; A J C Slooter; Bart Dermaut; Albert Hofman; Christine Van Broeckhoven; C.M. Duijn
The cystatin C polymorphism is not associated with early onset Alzheimer's disease.
Neurology 2001;57(2):366-7.
2001: Jan Meuleman; Vincent Timmerman; Christine Van Broeckhoven; Peter De Jonghe
Hereditary neuralgic amyotrophy.
Neurogenetics 2001;3(3):115-8.
2001: Gert Van Goethem; Bart Dermaut; Ann Löfgren; Jean-Jacques Martin; Christine Van Broeckhoven
Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions.
Nature genetics 2001;28(3):211-2.
2001: V F I Van Tendeloo; Peter Ponsaerts; Filip Lardon; Griet Nijs; Marc Lenjou; Christine Van Broeckhoven; Dirk R Van Bockstaele; Zwi N Berneman
Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells.
Blood 2001;98(1):49-56.
2001: Jessie Theuns; Lars Feuk; Bart Dermaut; Jurgen Del-Favero; Gerwin Roks; Dirk Van den Bossche; Ellen Corsmit; Marleen Van den Broeck; C.M. Duijn; Marc Cruts; Anthony J Brookes; Christine Van Broeckhoven
The TNFRSF6 gene is not implicated in familial early-onset Alzheimer's disease.
Human genetics 2001;108(6):552-3.
2001: Lieve R F Claes; Jurgen Del-Favero; Berten Ceulemans; Lieven Lagae; Christine Van Broeckhoven; Peter De Jonghe
De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy.
American journal of human genetics 2001;68(6):1327-32.
2001: Jan Meuleman; Gregor Kuhlenbäumer; Dominique Audenaert; Gert Hünermund; H Hor; Peter Young; Florian Stögbauer; E Bernd Ringelstein; Christine Van Broeckhoven; Peter De Jonghe; Vincent Timmerman
Mutation analysis of 4 candidate genes for hereditary neuralgic amyotrophy (HNA).
Human genetics 2001;108(5):390-3.
2001: Jan Meuleman; A Pou-Serradell; Ann Löfgren; Chantal Ceuterick; Jean-Jacques Martin; Vincent Timmerman; Christine Van Broeckhoven; Peter De Jonghe
A novel 3'-splice site mutation in peripheral myelin protein 22 causing hereditary neuropathy with liability to pressure palsies.
Neuromuscular disorders : NMD 2001;11(4):400-3.
2001: V F I Van Tendeloo; Christine Van Broeckhoven; Zwi N Berneman
Gene-based cancer vaccines: an ex vivo approach.
Leukemia 2001;15(4):545-58.
2001: V F I Van Tendeloo; Christine Van Broeckhoven; Zwi N Berneman
Gene therapy: principles and applications to hematopoietic cells.
Leukemia 2001;15(4):523-44.
2001: Martine Jacquier; D Arango; E Villareal; O Torres; M L Serrano; Marc Cruts; P Montañes; C Cano; M N Rodriguez; Sally Serneels; Christine Van Broeckhoven
APOE epsilon4 and Alzheimer's disease: positive association in a Colombian clinical series and review of the Latin-American studies.
Arquivos de neuro-psiquiatria 2001;59(1):11-7.
2001: Daniel Souery; S Van Gestel; Isabelle Massat; Sylvie Blairy; Rolf Adolfsson; Douglas Blackwood; Jurgen Del-Favero; Dimitris G Dikeos; Miro Jakovljevic; RAdka Kaneva; Enrico Lattuada; Bernard Lerer; Roberta Lilli; vihra milanova; Walter Muir; Markus M Nöthen; Lilijana Oruc; George N Papadimitriou; Peter Propping; Thomas G. Schulze; Alessandro Serretti; Baruch Shapira; Enrico Smeraldi; Costas N Stefanis; M Thomson; Christine Van Broeckhoven; Julien Mendlewicz
Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study.
Biological psychiatry 2001;49(5):405-9.
2001: Peter De Jonghe; I Mersivanova; Eva Nelis; Jurgen Del-Favero; Jean-Jacques Martin; Christine Van Broeckhoven; Oleg V Evgrafov; Vincent Timmerman
Further evidence that neurofilament light chain gene mutations can cause Charcot-Marie-Tooth disease type 2E.
Annals of neurology 2001;49(2):245-9.
2001: Dirk Roymans; Kris Vissenberg; Chris De Jonghe; Roel Willems; G Engler; N Kimura; Bert Grobben; Patrik Claes; Jean-Pierre Verbelen; Christine Van Broeckhoven; Herman Slegers
Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome.
Experimental cell research 2001;262(2):145-53.
2001: Chantal Ceuterick-de Groote; Peter De Jonghe; Vincent Timmerman; Gert Van Goethem; Ann Löfgren; Berten Ceulemans; Christine Van Broeckhoven; Jean-Jacques Martin
Infantile demyelinating neuropathy associated with a de novo point mutation on Ser72 in PMP22 and basal lamina onion bulbs in skin biopsy.
Pathology, research and practice 2001;197(3):193-8.
2001: Dirk Roymans; Kris Vissenberg; Chris De Jonghe; Bert Grobben; Patrik Claes; Jean-Pierre Verbelen; Christine Van Broeckhoven; Herman Slegers
Phosphatidylinositol 3-kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP-dependent induction of differentiation in rat C6 glioma.
Journal of neurochemistry 2001;76(2):610-8.
2000: Andrew Singleton; R Hall; Clive G Ballard; Robert H Perry; John H Xuereb; David C Rubinsztein; C Tysoe; P Matthews; Barbara Cordell; Samir Kumar-Singh; Chris De Jonghe; Marc Cruts; Christine Van Broeckhoven; Christopher M Morris
Pathology of early-onset Alzheimer's disease cases bearing the Thr113-114ins presenilin-1 mutation.
Brain : a journal of neurology 2000;123 Pt 12():2467-74.
2000: Dirk Roymans; Roel Willems; Kris Vissenberg; Chris De Jonghe; Bert Grobben; Patrik Claes; I Lascu; Dirk R Van Bockstaele; Jean-Pierre Verbelen; Christine Van Broeckhoven; Herman Slegers
Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma.
Experimental cell research 2000;261(1):127-38.
2000: Henry Houlden; M Baker; E McGowan; P Lewis; Michael Hutton; Richard Crook; Nicholas W Wood; Samir Kumar-Singh; J Geddes; M Swash; Francesco Scaravilli; Janice L Holton; Tammaryn Lashley; T Tomita; T Hashimoto; Auli Verkkoniemi; Hannu Kalimo; Mirja Somer; Anders Paetau; J J Martin; Christine Van Broeckhoven; todd golde; John Hardy; Matti Haltia; Tamas Revesz
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
Annals of neurology 2000;48(5):806-8.
2000: Samir Kumar-Singh; Chris De Jonghe; Marc Cruts; R Kleinert; Rong Wang; Marc Mercken; Bart De Strooper; hugo vanderstichele; Ann Löfgren; I Vanderhoeven; Hubert Backhovens; Eugeen Vanmechelen; P M Kroisel; Christine Van Broeckhoven
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
Human molecular genetics 2000;9(18):2589-98.
2000: V Timmerman; P De Jonghe; Christine Van Broeckhoven
Of giant axons and curly hair.
Nature genetics 2000;26(3):254-5.
2000: Jessie Theuns; Christine Van Broeckhoven
Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility.
Human molecular genetics 2000;9(16):2383-94.
2000: Gerwin Roks; Frans van Harskamp; Inge de Koning; Marc Cruts; Chris De Jonghe; Samir Kumar-Singh; A Tibben; Hervé L J Tanghe; Martinus F Niermeijer; Albert Hofman; John C van Swieten; Christine Van Broeckhoven; C.M. Duijn
Presentation of amyloidosis in carriers of the codon 692 mutation in the amyloid precursor protein gene (APP692).
Brain : a journal of neurology 2000;123 ( Pt 10)():2130-40.
2000: Florian Stögbauer; Vincent Timmerman; Christine Van Broeckhoven
71st ENMC International Workshop, 6th workshop of the European Charcot-Marie-Tooth disease consortium: hereditary recurrent focal neuropathies, 24-25 September 1999, Soestduinen, the Netherlands.
Neuromuscular disorders : NMD 2000;10(7):518-24.
2000: Esther A Croes; Bart Dermaut; Tischa J M van der Cammen; Christine Van Broeckhoven; C.M. Duijn
Genetic testing should not be advocated as a diagnostic tool in familial forms of dementia.
American journal of human genetics 2000;67(4):1033-5.
2000: M N Koster; Bart Dermaut; Marc Cruts; Jeanine J Houwing-Duistermaat; Gerwin Roks; Johannes L Tol; Alewijn Ott; Albert Hofman; G Munteanu; Monique Breteler; C.M. Duijn; Christine Van Broeckhoven
The alpha2-macroglobulin gene in AD: a population-based study and meta-analysis.
Neurology 2000;55(5):678-84.
2000: Peter Young; F Stögbauer; B Eller; Peter De Jonghe; Ann Löfgren; Vincent Timmerman; Bernd Rautenstrauss; K Oexle; H Grehl; Gregor Kuhlenbäumer; Christine Van Broeckhoven; E B Ringelstein; Harald Funke
PMP22 Thr118Met is not a clinically relevant CMT1 marker.
Journal of neurology 2000;247(9):696-700.
2000: V F I Van Tendeloo; Peter Ponsaerts; Christine Van Broeckhoven; Zwi N Berneman; Dirk R Van Bockstaele
Efficient generation of stably electrotransfected human hematopoietic cell lines without drug selection by consecutive FACsorting.
Cytometry 2000;41(1):31-5.
2000: V F I Van Tendeloo; Roel Willems; Peter Ponsaerts; Marc Lenjou; Griet Nijs; M Vanhove; Philip Muylaert; Philip Van Cauwelaert; Christine Van Broeckhoven; Dirk R Van Bockstaele; Zwi N Berneman
High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery.
Gene therapy 2000;7(16):1431-7.
2000: Geert Van Gassen; Chris De Jonghe; M Nishimura; Gang G. Yu; S Kuhn; Peter St George-Hyslop; Christine Van Broeckhoven
Evidence that the beta-catenin nuclear translocation assay allows for measuring presenilin 1 dysfunction.
Molecular medicine (Cambridge, Mass.) 2000;6(7):570-80.
2000: Gert Van Goethem; Ann Löfgren; Jean-Jacques Martin; Christine Van Broeckhoven
Further evidence for genetic heterogeneity of autosomal dominant disorders with accumulation of multiple deletions of mitochondrial DNA.
Journal of medical genetics 2000;37(7):547-8.
2000: Melvin G McInnis; T Swift-Scanlanl; Amy Mahoney; J Vincent; Greta Verheyen; Tsuo-Hung Lan; Lilijana Oruc; Olaf Riess; Christine Van Broeckhoven; H Chen; James L Kennedy; Dean F MacKinnon; Russell L Margolis; Sylvia G Simpson; Francis McMajon; Elliot S Gershon; John Nurnberger; Theodore Reich; J. Raymond DePaulo; Christopher A Ross
Allelic distribution of CTG18.1 in Caucasian populations: association studies in bipolar disorder, schizophrenia, and ataxia.
Molecular psychiatry 2000;5(4):439-42.
2000: Lynn E DeLisi; Nick Craddock; S Detera-Wadleigh; T Foroud; P Gejman; James L Kennedy; Corinne Lendon; F Macciardi; Patrick McKeon; Lesley Mynett-Johnson; J I Nurnberger; A Paterson; S Schwab; Christine Van Broeckhoven; Dieter B Wildenauer; T J Crow
Update on chromosomal locations for psychiatric disorders: report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey, California, October 14-18, 1999.
American journal of medical genetics 2000;96(3):434-49.
2000: Sylvie Blairy; Isabelle Massat; Luc Staner; Olivier Le Bon; S Van Gestel; Christine Van Broeckhoven; Christiane Hilger; François Hentges; Daniel Souery; Julien Mendlewicz
5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait.
American journal of medical genetics 2000;96(3):360-4.
2000: Geert Van Gassen; Christine Van Broeckhoven
Molecular genetics of Alzheimer's disease: what have we learned?
Acta neurologica Belgica 2000;100(2):65-76.
2000: Machteld Wauters; R Considine; A Löfgren; Christine Van Broeckhoven; J C Van der Auwera; I De Leeuw; Luc Van Gaal
Associations of leptin with body fat distribution and metabolic parameters in non-insulin-dependent diabetic patients: no effect of apolipoprotein E polymorphism.
Metabolism: clinical and experimental 2000;49(6):724-30.
2000: Geert Van Gassen; Willem ANNAERT; Christine Van Broeckhoven
Binding partners of Alzheimer's disease proteins: are they physiologically relevant?
Neurobiology of disease 2000;7(3):135-51.
2000: Bart Dermaut; Marc Cruts; Hubert Backhovens; Ursula Lübke; Bart Van Everbroeck; Raf Sciot; René Dom; Jean-Jacques Martin; Christine Van Broeckhoven; Patrick Cras
Familial Creutzfeldt-Jakob disease in a patient carrying both a presenilin 1 missense substitution and a prion protein gene insertion.
Journal of neurology 2000;247(5):364-8.
2000: Dirk Goossens; Sandra M Villafuerte; F Tissir; S Van Gestel; Stephan J Claes; Daniel Souery; Isabelle Massat; Dirk Van den Bossche; K Van Zand; Julien Mendlewicz; Christine Van Broeckhoven; Jurgen Del-Favero
No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder.
European journal of human genetics : EJHG 2000;8(5):385-8.
2000: Isabelle Massat; Daniel Souery; O Lipp; Sylvie Blairy; George N Papadimitriou; Dimitris G Dikeos; Manfred Ackenheil; S Fuchshuber; Christiane Hilger; RAdka Kaneva; vihra milanova; Greta Verheyen; Petra Raeymaekers; Luc Staner; Lilijana Oruc; Miro Jakovljevic; Alessandro Serretti; Fabio Macciardi; Christine Van Broeckhoven; Julien Mendlewicz
A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder.
American journal of medical genetics 2000;96(2):136-40.
2000: Joy Irobi; F Tissir; Peter De Jonghe; Els De Vriendt; Christine Van Broeckhoven; Vincent Timmerman; J Beuten
A clone contig of 12q24.3 encompassing the distal hereditary motor neuropathy type II gene.
Genomics 2000;65(1):34-43.
2000: Pieter Jelle Visser; Frans Verhey; Rudolf W H M Ponds; Marc Cruts; Christine Van Broeckhoven; Jelle Jolles
Course of objective memory impairment in non-demented subjects attending a memory clinic and predictors of outcome.
International journal of geriatric psychiatry 2000;15(4):363-72.
2000: Alessandro Serretti; Fabio Macciardi; Cristina Cusin; Enrico Lattuada; Daniel Souery; O Lipp; B Mahieu; Christine Van Broeckhoven; D Blackwood; Walter Muir; Harald N Aschauer; Angela Heiden; M Ackenheil; S Fuchshuber; Petra Raeymaekers; Greta Verheyen; RAdka Kaneva; A Jablensky; George N Papadimitriou; Dimitris G Dikeos; Costas N Stefanis; Enrico Smeraldi; Julien Mendlewicz
Linkage of mood disorders with D2, D3 and TH genes: a multicenter study.
Journal of affective disorders 2000;58(1):51-61.
2000: Biswadjiet S Harhangi; Maarten C de Rijk; C.M. Duijn; Christine Van Broeckhoven; Albert Hofman; Monique Breteler
APOE and the risk of PD with or without dementia in a population-based study.
Neurology 2000;54(6):1272-6.
2000: S Van Gestel; Jeanine J Houwing-Duistermaat; Rolf Adolfsson; C.M. Duijn; Christine Van Broeckhoven
Power of selective genotyping in genetic association analyses of quantitative traits.
Behavior genetics 2000;30(2):141-6.
2000: Jessie Theuns; Jurgen Del-Favero; Bart Dermaut; C.M. Duijn; Hubert Backhovens; Marleen Van den Broeck; Sally Serneels; Ellen Corsmit; Christine Van Broeckhoven; Marc Cruts
Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression.
Human molecular genetics 2000;9(3):325-31.
2000: Samir Kumar-Singh; Ilse Dewachter; Dieder Moechars; Ursula Lübke; Chris De Jonghe; Chantal Ceuterick; F Checler; Asha Naidu; Barbara Cordell; Patrick Cras; Christine Van Broeckhoven; Fred Van Leuven
Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.
Neurobiology of disease 2000;7(1):9-22.
2000: Irina V Mersiyanova; S M Ismailov; Alexander V Polyakov; Elena L Dadali; Valeriy Fedotov; Eva Nelis; Ann Löfgren; Vincent Timmerman; Christine Van Broeckhoven; Oleg V Evgrafov
Screening for mutations in the peripheral myelin genes PMP22, MPZ and Cx32 (GJB1) in Russian Charcot-Marie-Tooth neuropathy patients.
Human mutation 2000;15(4):340-7.
2000: R Martini; J Berciano; Christine Van Broeckhoven
5th Workshop of the European CMT Consortium, 69th ENMC International Workshop: therapeutic approaches in CMT neuropathies and related disorders 23-25 April 1999, Soestduinen, The Netherlands.
Neuromuscular disorders : NMD 2000;10(1):69-74.
2000: L Leonardis; Janez Zidar; Mara Popovic; V Timmerman; A Löfgren; Christine Van Broeckhoven; Dusan Butinar
Hereditary motor and sensory neuropathy associated with auditory neuropathy in a Gypsy family.
Pflügers Archiv : European journal of physiology 2000;439(3 Suppl):R208-10.
1999: Gerwin Roks; Bart Dermaut; Peter Heutink; Ann Julliams; Hubert Backhovens; M Van de Broeck; Sally Serneels; Albert Hofman; Christine Van Broeckhoven; C.M. Duijn; Marc Cruts
Mutation screening of the tau gene in patients with early-onset Alzheimer's disease.
Neuroscience letters 1999;277(2):137-9.
1999: C Mauger; Jurgen Del-Favero; Chantal Ceuterick; Ursula Lübke; Christine Van Broeckhoven; J Martin
Identification and localization of ataxin-7 in brain and retina of a patient with cerebellar ataxia type II using anti-peptide antibody.
Brain research. Molecular brain research 1999;74(1-2):35-43.
1999: Gregor Kuhlenbäumer; Anja Schirmacher; Jan Meuleman; F Tissir; Jurgen Del-Favero; Florian Stögbauer; Peter Young; Bernd Ringelstein; Christine Van Broeckhoven; Vincent Timmerman
A sequence-ready BAC/PAC contig and partial transcript map of approximately 1.5 Mb in human chromosome 17q25 comprising multiple disease genes.
Genomics 1999;62(2):242-50.
1999: J Meulemann; Gregor Kuhlenbäumer; Anja Schirmacher; Manfred Wehnert; Peter De Jonghe; Els De Vriendt; Peter Young; E Airaksinen; A Pou-Serradell; J M Prats; Bernd Ringelstein; Florian Stögbauer; Christine Van Broeckhoven; Vincent Timmerman
Genetic refinement of the hereditary neuralgic amyotrophy (HNA) locus at chromosome 17q25.
European journal of human genetics : EJHG 1999;7(8):920-7.
1999: A J C Slooter; J Bronzova; Jacqueline C M Witteman; Christine Van Broeckhoven; Albert Hofman; C.M. Duijn
Estrogen use and early onset Alzheimer's disease: a population-based study.
Journal of neurology, neurosurgery, and psychiatry 1999;67(6):779-81.
1999: A Michalík; Jurgen Del-Favero; C Mauger; Ann Löfgren; Christine Van Broeckhoven
Genomic organisation of the spinocerebellar ataxia type 7 (SCA7) gene responsible for autosomal dominant cerebellar ataxia with retinal degeneration.
Human genetics 1999;105(5):410-7.
1999: S Y Wang; Marc Cruts; Jurgen Del-Favero; Y Zhang; F Tissir; Marie-Claude Potier; D Patterson; Dean Nizetic; A Bosch; Haiming Chen; L Bennett; X Estivill; AM Kessling; Stylianos E Antonarakis; Christine Van Broeckhoven
A high-resolution physical map of human chromosome 21p using yeast artificial chromosomes.
Genome research 1999;9(11):1059-73.
1999: I Vanderhoeven; Patrick Cras; Jean-Jacques Martin; Christine Van Broeckhoven; Chris De Jonghe
Proteolytic processing of presenilin-1 in human lymphoblasts is not affected by the presence of the I143T and G384A mutations.
Neuroscience letters 1999;274(3):183-6.
1999: A J C Slooter; Marc Cruts; Alewijn Ott; Michiel Bots; Jacqueline C M Witteman; Albert Hofman; Christine Van Broeckhoven; Monique Breteler; C.M. Duijn
The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study.
Neurology 1999;53(7):1593-5.
1999: C.M. Duijn; Marc Cruts; Jessie Theuns; G Van Gassen; Hubert Backhovens; Marleen Van den Broeck; A Wehnert; Sally Serneels; Albert Hofman; Christine Van Broeckhoven
Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample.
European journal of human genetics : EJHG 1999;7(7):801-6.
1999: Greta Verheyen; Jurgen Del-Favero; Julien Mendlewicz; Kerstin Lindblad; K Van Zand; M Aalbregtse; Martin Schalling; Daniel Souery; Christine Van Broeckhoven
Molecular interpretation of expanded RED products in bipolar disorder by CAG/CTG repeats located at chromosomes 17q and 18q.
Neurobiology of disease 1999;6(5):424-32.
1999: Geert Van Gassen; Chris De Jonghe; Stefan Pype; Wim van Criekinge; Ann Julliams; I Vanderhoeven; S Woodrow; Rudi Beyaert; Danny Huylebroeck; Christine Van Broeckhoven
Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome.
Neurobiology of disease 1999;6(5):376-91.
1999: Peter De Jonghe; Vincent Timmerman; Eva Nelis; Els De Vriendt; Ann Löfgren; Chantal Ceuterick; Jean-Jacques Martin; Christine Van Broeckhoven
A novel type of hereditary motor and sensory neuropathy characterized by a mild phenotype.
Archives of neurology 1999;56(10):1283-8.
1999: J Martin; Nicole Van Regemorter; Jurgen Del-Favero; Ann Löfgren; Christine Van Broeckhoven
Spinocerebellar ataxia type 7 (SCA7) - correlations between phenotype and genotype in one large Belgian family.
Journal of the neurological sciences 1999;168(1):37-46.
1999: A Kochański; Vincent Timmerman; Hanna Jedrzejowska; Barbara Ryniewicz; Ann Löfgren; Els De Vriendt; Christine Van Broeckhoven; A Latos-Bieleńska; Irena Hausmanowa-Petrusewicz
Mutation screening of Charcot-Marie-Tooth patients in Poland.
Annals of the New York Academy of Sciences 1999;883():493-6.
1999: Joy Irobi; Vincent Timmerman; Peter De Jonghe; Els De Vriendt; Christine Van Broeckhoven; J Beuten
Construction of a PAC contig within the distal hereditary motor neuropathy type II candidate region at 12q24.
Annals of the New York Academy of Sciences 1999;883():463-5.
1999: Ann Löfgren; Anick De Vos; Karen Sermon; I Liebaers; A Van Steirteghem; Christine Van Broeckhoven
Preimplantation diagnosis for Charcot-Marie-Tooth type 1A.
Annals of the New York Academy of Sciences 1999;883():460-2.
1999: Gregor Kuhlenbäumer; Peter Young; Reinhard Kiefer; Vincent Timmerman; J F Wang; J M Schroeder; J Weis; E Bernd Ringelstein; Christine Van Broeckhoven; F Stoegbauer
A second family with autosomal dominant burning feet syndrome.
Annals of the New York Academy of Sciences 1999;883():445-8.
1999: Jan Meuleman; Gregor Kuhlenbäumer; Anja Schirmacher; Manfred Wehnert; Peter Young; Florian Stögbauer; E Bernd Ringelstein; Christine Van Broeckhoven; Vincent Timmerman
Hereditary neuralgic amyotrophy: mutation analysis of candidate genes.
Annals of the New York Academy of Sciences 1999;883():443-4.
1999: Peter De Jonghe; Eva Nelis; Vincent Timmerman; Ann Löfgren; Jean-Jacques Martin; Christine Van Broeckhoven
Molecular diagnostic testing in Charcot-Marie-Tooth disease and related disorders. Approaches and results.
Annals of the New York Academy of Sciences 1999;883():389-96.
1999: Vincent Timmerman; J Beuten; Joy Irobi; Peter De Jonghe; Jean-Jacques Martin; Christine Van Broeckhoven
Distal hereditary motor neuropathy type II (distal HMN type II): phenotype and molecular genetics.
Annals of the New York Academy of Sciences 1999;883():60-4.
1999: Jurgen Del-Favero; Dirk Goossens; Peter De Jonghe; K Benson; Andrej Michalik; Dirk Van den Bossche; M Horwitz; Christine Van Broeckhoven
Isolation of CAG/CTG repeats from within the chromosome 2p21-p24 locus for autosomal dominant spastic paraplegia (SPG4) by YAC fragmentation.
Human genetics 1999;105(3):217-25.
1999: Eva Nelis; Vincent Timmerman; Peter De Jonghe; Christine Van Broeckhoven; Bernd Rautenstrauss
Molecular genetics and biology of inherited peripheral neuropathies: a fast-moving field.
Neurogenetics 1999;2(3):137-48.
1999: Chris De Jonghe; Patrick Cras; hugo vanderstichele; Marc Cruts; I Vanderhoeven; Iris Smouts; Eugeen Vanmechelen; Jean-Jacques Martin; L Hendriks; Christine Van Broeckhoven
Evidence that Abeta42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phenotype.
Neurobiology of disease 1999;6(4):280-7.
1999: Chris De Jonghe; Marc Cruts; Ekaterina Rogaeva; C Tysoe; Andrew Singleton; hugo vanderstichele; W Meschino; Bart Dermaut; I Vanderhoeven; Hubert Backhovens; Eugeen Vanmechelen; Christopher M Morris; John Hardy; David C Rubinsztein; Peter St George-Hyslop; Christine Van Broeckhoven
Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.
Human molecular genetics 1999;8(8):1529-40.
1999: Ann Julliams; I Vanderhoeven; S Kuhn; Christine Van Broeckhoven; Chris De Jonghe
No influence of presenilin1 I143T and G384A mutations on endogenous tau phosphorylation in human and mouse neuroblastoma cells.
Neuroscience letters 1999;269(2):83-6.
1999: Florian Stögbauer; Peter Young; Gregor Kuhlenbäumer; Reinhard Kiefer; Vincent Timmerman; E Bernd Ringelstein; J F Wang; J M Schröder; Christine Van Broeckhoven; J Weis
Autosomal dominant burning feet syndrome.
Journal of neurology, neurosurgery, and psychiatry 1999;67(1):78-81.
1999: Christine Van Broeckhoven; Greta Verheyen
Report of the chromosome 18 workshop.
American journal of medical genetics 1999;88(3):263-70.
1999: Vincent Timmerman; Peter De Jonghe; Chantal Ceuterick; Els De Vriendt; Ann Löfgren; Eva Nelis; L E Warner; James R Lupski; Jean-Jacques Martin; Christine Van Broeckhoven
Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype.
Neurology 1999;52(9):1827-32.
1999: Thomas Liehr; Gregor Kuhlenbäumer; P Wulf; V Taylor; U Suter; Christine Van Broeckhoven; J R Lupski; U Claussen; Bernd Rautenstrauss
Regional localization of the human epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3.
Genomics 1999;58(1):106-8.
1999: Greta Verheyen; Sandra M Villafuerte; Jurgen Del-Favero; Daniel Souery; Julien Mendlewicz; Christine Van Broeckhoven; Petra Raeymaekers
Genetic refinement and physical mapping of a chromosome 18q candidate region for bipolar disorder.
European journal of human genetics : EJHG 1999;7(4):427-34.
1999: A J C Slooter; Jeanine J Houwing-Duistermaat; Frans van Harskamp; Marc Cruts; Christine Van Broeckhoven; Monique Breteler; Albert Hofman; T Stijnen; C.M. Duijn
Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study.
Journal of neurology 1999;246(4):304-8.
1999: Jessie Theuns; Marc Cruts; Jurgen Del-Favero; Dirk Goossens; Hans Dauwerse; A Wehnert; Johan T den Dunnen; Christine Van Broeckhoven
Determination of the genomic organization of human presenilin 1 by fiber-FISH analysis and restriction mapping of cloned DNA.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(4):410-4.
1999: Jurgen Del-Favero; Dirk Goossens; Dirk Van den Bossche; Christine Van Broeckhoven
YAC fragmentation with repetitive and single-copy sequences: detailed physical mapping of the presenilin 1 gene on chromosome 14.
Gene 1999;229(1-2):193-201.
1999: M Van de Craen; Chris De Jonghe; I Van den Brande; Wim Declercq; Geert Van Gassen; Wim van Criekinge; I Vanderhoeven; Walter Fiers; Christine Van Broeckhoven; L Hendriks; Peter Vandenabeele
Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.
FEBS letters 1999;445(1):149-54.
1999: M Bähr; F Andres; V Timmerman; M E Nelis; Christine Van Broeckhoven; J Dichgans
Central visual, acoustic, and motor pathway involvement in a Charcot-Marie-Tooth family with an Asn205Ser mutation in the connexin 32 gene.
Journal of neurology, neurosurgery, and psychiatry 1999;66(2):202-6.
1999: Peter De Jonghe; Vincent Timmerman; Chantal Ceuterick; Eva Nelis; Els De Vriendt; Ann Löfgren; A Vercruyssen; Christine Verellen; Lionel Van Maldergem; Jean-Jacques Martin; Christine Van Broeckhoven
The Thr124Met mutation in the peripheral myelin protein zero (MPZ) gene is associated with a clinically distinct Charcot-Marie-Tooth phenotype.
Brain : a journal of neurology 1999;122 ( Pt 2)():281-90.
1999: Vincent Timmerman; Peter De Jonghe; Christine Van Broeckhoven
Report of the 8th annual symposium of the European Charcot-Marie-Tooth Consortium, Antwerpen, Belgium, July 2-4, 1999.
Journal of the peripheral nervous system : JPNS 1999;4(3-4):279-304.
1999: J Martin; L Martin; Ann Löfgren; M D'Hooghe; Katrien Storm; Wendy Balemans; F Palau; Christine Van Broeckhoven
Classical Friedreich's ataxia and its genotype.
European neurology 1999;42(2):109-15.
1999: E A Stronach; C Clark; C Bell; A Löfgren; Neil G McKay; V Timmerman; Christine Van Broeckhoven; Neva E Haites
Novel PCR-based diagnostic tools for Charcot-Marie-Tooth type 1A and hereditary neuropathy with liability to pressure palsies.
Journal of the peripheral nervous system : JPNS 1999;4(2):117-22.
1999: Bart Dermaut; Marc Cruts; A J C Slooter; S Van Gestel; Chris De Jonghe; hugo vanderstichele; Eugeen Vanmechelen; Monique Breteler; Albert Hofman; C.M. Duijn; Christine Van Broeckhoven
The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease.
American journal of human genetics 1999;64(1):290-2.
1999: Eva Nelis; N Haites; Christine Van Broeckhoven
Mutations in the peripheral myelin genes and associated genes in inherited peripheral neuropathies.
Human mutation 1999;13(1):11-28.
1998: Gerwin Roks; Marc Cruts; María J Bullido; Hubert Backhovens; María J Artiga; Albert Hofman; Fernando Valdivieso; Christine Van Broeckhoven; C.M. Duijn
The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.
Neuroscience letters 1998;258(2):65-8.
1998: Marc Cruts; Christine Van Broeckhoven
Molecular genetics of Alzheimer's disease.
Annals of medicine 1998;30(6):560-5.
1998: Chris De Jonghe; Cynthia Zehr; D Yager; CM Prada; Steven G Younkin; L Hendriks; Christine Van Broeckhoven; Christopher B Eckman
Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.
Neurobiology of disease 1998;5(4):281-6.
1998: Arif B Ekici; Christina Fuchs; Eva Nelis; R Hillenbrand; Melitta Schachner; Christine Van Broeckhoven; Bernd Rautenstrauss
An adhesion test system based on Schneider cells to determine genotype-phenotype correlations for mutated P0 proteins.
Genetic analysis : biomolecular engineering 1998;14(4):117-9.
1998: Anick De Vos; Karen Sermon; Hilde Van De Velde; Hubert Joris; M Vandervorst; Willy Lissens; G Mortier; P De Sutter; Ann Löfgren; Christine Van Broeckhoven; Inge Liebaers; André Van Steirteghem
Pregnancy after preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A.
Molecular human reproduction 1998;4(10):978-84.
1998: G Kuhlenbaeumer; Jan Meuleman; Anja Schirmacher; F Stoegbauer; E Bernd Ringelstein; Manfred Wehnert; M Hoeltzenbein; Christine Van Broeckhoven; Vincent Timmerman
Mutation analysis of a putative sialyltransferase gene, the SFRS2 splicing factor gene and the c-myb ET-locus in two families with hereditary neuralgic amyotrophy (HNA).
Annals of human genetics 1998;62(Pt 5):397-400.
1998: Patrick Cras; F van Harskamp; L Hendriks; Chantal Ceuterick; C.M. Duijn; S Z Stefanko; Albert Hofman; J M Kros; Christine Van Broeckhoven; Jean-Jacques Martin
Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.
Acta neuropathologica 1998;96(3):253-60.
1998: Marie-Claude Potier; A Dutriaux; R Orti; Jürgen Groet; Nathalie Gibelin; GEORGIA KARADIMA; G Lutfalla; A Lynn; Christine Van Broeckhoven; Aravinda Chakravarti; M Petersen; Dean Nizetic; Jean-Maurice Delabar; Jean Rossier
Two sequence-ready contigs spanning the two copies of a 200-kb duplication on human 21q: partial sequence and polymorphisms.
Genomics 1998;51(3):417-26.
1998: Marcello Villanova; V Timmerman; P De Jonghe; Alessandro Malandrini; N Rizzuto; Christine Van Broeckhoven; Gianni Guazzi; Alessandro Rossi
Charcot-Marie-Tooth disease: an intermediate form.
Neuromuscular disorders : NMD 1998;8(6):392-3.
1998: Tischa J M van der Cammen; C J Verschoor; C P van Loon; Frans van Harskamp; Inge de Koning; W Joost Schudel; A J C Slooter; Christine Van Broeckhoven; C.M. Duijn
Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele.
Journal of the American Geriatrics Society 1998;46(8):962-7.
1998: Eva Nelis; Peter De Jonghe; Els De Vriendt; P I Patel; Jean-Jacques Martin; Christine Van Broeckhoven
Mutation analysis of the nerve specific promoter of the peripheral myelin protein 22 gene in CMT1 disease and HNPP.
Journal of medical genetics 1998;35(7):590-3.
1998: A J C Slooter; Marc Cruts; Sandra Kalmijn; Albert Hofman; Monique Breteler; Christine Van Broeckhoven; C.M. Duijn
Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.
Archives of neurology 1998;55(7):964-8.
1998: Caroline C W Klaver; Mike Kliffen; C.M. Duijn; Albert Hofman; Marc Cruts; Diederick Grobbee; Christine Van Broeckhoven; Paulus T V M de Jong
Genetic association of apolipoprotein E with age-related macular degeneration.
American journal of human genetics 1998;63(1):200-6.
1998: Alewijn Ott; A J C Slooter; Albert Hofman; Frans van Harskamp; Jacqueline C M Witteman; Christine Van Broeckhoven; C.M. Duijn; Monique Breteler
Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study.
Lancet 1998;351(9119):1840-3.
1998: A J C Slooter; P de Knijff; Albert Hofman; Marc Cruts; Monique Breteler; Christine Van Broeckhoven; L M Havekes; C.M. Duijn
Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam study.
Neuroscience letters 1998;248(1):21-4.
1998: V F I Van Tendeloo; Hans-Willem Snoeck; Filip Lardon; Guido Vanham; Griet Nijs; Marc Lenjou; L Hendriks; Christine Van Broeckhoven; Adriaan C Moulijn; Inez E Rodrigus; P Verdonk; Dirk R Van Bockstaele; Zwi N Berneman
Nonviral transfection of distinct types of human dendritic cells: high-efficiency gene transfer by electroporation into hematopoietic progenitor- but not monocyte-derived dendritic cells.
Gene therapy 1998;5(5):700-7.
1998: Akira Tamaoka; Paul E Fraser; Kazuhiro Ishii; N Sahara; K Ozawa; Masaki Ikeda; Ann M Saunders; Yasuko Komatsuzaki; R Sherrington; Georges Levesque; Gang G. Yu; Ekaterina Rogaeva; Shin'ichi Shoji; Linda E Nee; Daniel A Pollen; L Hendriks; J J Martin; Christine Van Broeckhoven; Allen D Roses; Lindsay A Farrer; Peter St George-Hyslop; Hiroshi Mori
Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease.
Brain research. Molecular brain research 1998;56(1-2):178-85.
1998: Lawrence Reiter; Philip J Hastings; Eva Nelis; Peter De Jonghe; Christine Van Broeckhoven; James R Lupski
Human meiotic recombination products revealed by sequencing a hotspot for homologous strand exchange in multiple HNPP deletion patients.
American journal of human genetics 1998;62(5):1023-33.
1998: Jürgen Groet; JH Ives; Andrew P South; P R Baptista; TA Jones; Marie-Laure Yaspo; H Lehrach; Marie-Claude Potier; Christine Van Broeckhoven; D Nizetić
Bacterial contig map of the 21q11 region associated with Alzheimer's disease and abnormal myelopoiesis in Down syndrome.
Genome research 1998;8(4):385-98.
1998: A Gambardella; Alessandra Bolino; Maria Muglia; Paola Valentino; Francesco Bono; RL Oliveri; M Sabatelli; V Brancolini; Christine Van Broeckhoven; Giovanni Romeo; Marcella Devoto; A Quattrone
Genetic heterogeneity in autosomal recessive hereditary motor and sensory neuropathy with focally folded myelin sheaths (CMT4B).
Neurology 1998;50(3):799-801.
1998: Peter Young; Florian Stögbauer; Heiko Wiebusch; Ann Löfgren; Vincent Timmerman; Christine Van Broeckhoven; E Bernd Ringelstein; Gerd Assmann; Harald Funke
PCR-based strategy for the diagnosis of hereditary neuropathy with liability to pressure palsies and Charcot-Marie-Tooth disease type 1A.
Neurology 1998;50(3):760-3.
1998: Henry Houlden; Richard Crook; Hubert Backhovens; Guy Prihar; Matt Baker; Michael Hutton; Martin N Rossor; J J Martin; Christine Van Broeckhoven; John Hardy
ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.
American journal of medical genetics 1998;81(1):117-21.
1998: L Hendriks; Chris De Jonghe; Ursula Lübke; S Woodrow; I Vanderhoeven; Jef Boons; Patrick Cras; Jean-Jacques Martin; Christine Van Broeckhoven
Immunoreactivity of presenilin-1 and tau in Alzheimer's disease brain.
Experimental neurology 1998;149(2):341-8.
1998: Jurgen Del-Favero; Luc Krols; Andrej Michalik; Jessie Theuns; Ann Löfgren; Dirk Goossens; A Wehnert; Dirk Van den Bossche; K Van Zand; Hubert Backhovens; N van Regenmorter; Jean-Jacques Martin; Christine Van Broeckhoven
Molecular genetic analysis of autosomal dominant cerebellar ataxia with retinal degeneration (ADCA type II) caused by CAG triplet repeat expansion.
Human molecular genetics 1998;7(2):177-86.
1998: Koenraad G Monsieurs; Christine Van Broeckhoven; J J Martin; V O Van Hoof; L Heytens
Gly341Arg mutation indicating malignant hyperthermia susceptibility: specific cause of chronically elevated serum creatine kinase activity.
Journal of the neurological sciences 1998;154(1):62-5.
1998: Florian Stögbauer; Peter Young; Heiko Wiebusch; Vincent Timmerman; Gregor Kuhlenbäumer; Eva Nelis; E Bernd Ringelstein; Gerhard Kurlemann; Gerd Assmann; Christine Van Broeckhoven; Harald Funke
Absence of mutations in peripheral myelin protein-22, myelin protein zero, and connexin 32 in autosomal recessive Dejerine-Sottas syndrome.
Neuroscience letters 1998;240(1):1-4.
1998: R Besançon; A Lorenzi; Marc Cruts; S Radawiec; FG Sturtz; Emmanuel Broussolle; Guy Chazot; Christine Van Broeckhoven; G Chamba; Antoon Vandenberghe
Missense mutation in exon 11 (Codon 378) of the presenilin-1 gene in a French family with early-onset Alzheimer's disease and transmission study by mismatch enhanced allele specific amplification. Mutations in brief no. 141. Online. besancon@rockefeller1.univ.lyon1.fr.
Human mutation 1998;11(6):481.
1998: Christine Van Broeckhoven
Alzheimer's disease: identification of genes and genetic risk factors.
Progress in brain research 1998;117():315-25.
1998: A J C Slooter; C.M. Duijn; Michiel Bots; A Ott; Monique Breteler; J De Voecht; A Wehnert; P de Knijff; L M Havekes; Diederick Grobbee; Christine Van Broeckhoven; Albert Hofman
Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam Study.
Journal of neural transmission. Supplementum 1998;53():17-29.
1998: Christine Van Broeckhoven; Greta Verheyen
Chromosome 18 workshop.
Psychiatric genetics 1998;8(2):97-108.
1998: Gemma Marfany; J Del-Favero; R Valero; Chris De Jonghe; S Woodrow; L Hendriks; Christine Van Broeckhoven; Roser Gonzàlez-Duarte
Identification of a Drosophila presenilin homologue: evidence of alternatively spliced forms.
Journal of neurogenetics 1998;12(1):41-54.
1998: Florian Stögbauer; Peter Young; Gregor Kuhlenbäumer; Jan Meuleman; Vincent Timmerman; Christine Van Broeckhoven; Gerhard Kurlemann; E Bernd Ringelstein
[Hereditary neural amyotrophy (HNA): clinical and molecular genetic basis].
Fortschritte der Neurologie-Psychiatrie 1998;66(1):10-4.
1998: Bernd Rautenstrauss; Christina Fuchs; Arif B Ekici; Eva Nelis; Christine Van Broeckhoven; Thomas Liehr
Assay of transfection rate in insect cells on a single cell level.
Genetic analysis : biomolecular engineering 1998;14(3):103-4.
1998: Marc Cruts; Christine Van Broeckhoven
Presenilin mutations in Alzheimer's disease.
Human mutation 1998;11(3):183-90.
1998: Karin Michels-Rautenstrauss; Christian Y Mardin; W M Budde; Thomas Liehr; J Polansky; T Nguyen; V Timmerman; Christine Van Broeckhoven; Gottfried Naumann; RA Pfeiffer; Bernd Rautenstrauss
Juvenile open angle glaucoma: fine mapping of the TIGR gene to 1q24.3-q25.2 and mutation analysis.
Human genetics 1998;102(1):103-6.
1998: C Tysoe; J Whittaker; John H Xuereb; Nigel J Cairns; Marc Cruts; Christine Van Broeckhoven; Gordon K Wilcock; David C Rubinsztein
A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer disease.
American journal of human genetics 1998;62(1):70-6.
1998: Marc Cruts; C.M. Duijn; Hubert Backhovens; Marleen Van den Broeck; A Wehnert; Sally Serneels; R Sherrington; Michael Hutton; John Hardy; Peter St George-Hyslop; Albert Hofman; Christine Van Broeckhoven
Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease.
Human molecular genetics 1998;7(1):43-51.
1997: Julien Mendlewicz; K Lindbald; Daniel Souery; B Mahieu; Per-Olof Nylander; A De Bruyn; Cecilia Zander; Christer Engström; Rolf Adolfsson; Christine Van Broeckhoven; Martin Schalling; O Lipp
Expanded trinucleotide CAG repeats in families with bipolar affective disorder.
Biological psychiatry 1997;42(12):1115-22.
1997: Marjolijn Bornebroek; Rudi G J Westendorp; Joost Haan; Egbert Bakker; W F Timmers; Christine Van Broeckhoven; Raymund A C Roos
Mortality from hereditary cerebral haemorrhage with amyloidosis--Dutch type. The impact of sex, parental transmission and year of birth.
Brain : a journal of neurology 1997;120 ( Pt 12)():2243-9.
1997: M Okochi; Kazuhiro Ishii; Mihoko Usami; N Sahara; Fuyuki Kametani; K Tanaka; Paul E Fraser; Masaki Ikeda; Ann M Saunders; L Hendriks; Shin'ichi Shoji; Linda E Nee; J J Martin; Christine Van Broeckhoven; Peter St George-Hyslop; Allen D Roses; Hiroshi Mori
Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations.
FEBS letters 1997;418(1-2):162-6.
1997: Patrick Marichal; Hugo F Vanden Bossche; Frank C Odds; G Nobels; D W Warnock; V Timmerman; Christine Van Broeckhoven; S Fay; P Mose-Larsen
Molecular biological characterization of an azole-resistant Candida glabrata isolate.
Antimicrobial agents and chemotherapy 1997;41(10):2229-37.
1997: Lilijana Oruc; Greta Verheyen; I Furac; M Jakovljević; S Ivezić; Petra Raeymaekers; Christine Van Broeckhoven
Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder.
American journal of medical genetics 1997;74(5):504-6.
1997: R Orti; A Mégarbane; C Maunoury; Christine Van Broeckhoven; Pierre-Marie Sinet; Jean-Maurice Delabar
High-resolution physical mapping of a 6.7-Mb YAC contig spanning a region critical for the monosomy 21 phenotype in 21q21.3-q22.1.
Genomics 1997;43(1):25-33.
1997: Marjolijn Bornebroek; Joost Haan; Hubert Backhovens; P Deutz; Mark A Van Buchem; Marleen Van den Broeck; Egbert Bakker; Raymund A C Roos; Christine Van Broeckhoven
Presenilin-1 polymorphism and hereditary cerebral hemorrhage with amyloidosis, Dutch type.
Annals of neurology 1997;42(1):108-10.
1997: Peter De Jonghe; Vincent Timmerman; D FitzPatrick; P Spoelders; Jean-Jacques Martin; Christine Van Broeckhoven
Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family.
Journal of neurology, neurosurgery, and psychiatry 1997;62(6):570-3.
1997: Manfred Wehnert; Vincent Timmerman; P Spoelders; Jan Meuleman; Eva Nelis; Christine Van Broeckhoven
Further evidence supporting linkage of hereditary neuralgic amyotrophy to chromosome 17q.
Neurology 1997;48(6):1719-21.
1997: M Stevens; C.M. Duijn; P de Knijff; Christine Van Broeckhoven; Peter Heutink; B A Oostra; M F Niermeijer; John C van Swieten
Apolipoprotein E gene and sporadic frontal lobe dementia.
Neurology 1997;48(6):1526-9.
1997: S Bort; Eva Nelis; V Timmerman; Teresa Sevilla; Antonio Cruz-Martínez; Francisco Martínez; José M Millán; Javier Arpa; Juan J Vílchez; Félix Prieto; Christine Van Broeckhoven; Francesc Palau
Mutational analysis of the MPZ, PMP22 and Cx32 genes in patients of Spanish ancestry with Charcot-Marie-Tooth disease and hereditary neuropathy with liability to pressure palsies.
Human genetics 1997;99(6):746-54.
1997: Rachel L Robinson; Nicole Monnier; Werner Wolz; M Jung; A Reis; G Nuernberg; JL Curran; Koenraad G Monsieurs; P Stieglitz; Luc Heytens; R Fricker; Christine Van Broeckhoven; T Deufel; Philip M Hopkins; Joël Lunardi; CR Mueller
A genome wide search for susceptibility loci in three European malignant hyperthermia pedigrees.
Human molecular genetics 1997;6(6):953-61.
1997: Mario Ezquerra; Rafael Blesa; Eduardo Tolosa; S Lopez Pousa; M Aguilar; J Peña; Christine Van Broeckhoven; F Ballesta; Rafael Oliva
The genotype 2/2 of the presenilin-1 polymorphism is decreased in Spanish early-onset Alzheimer's disease.
Neuroscience letters 1997;227(3):201-4.
1997: L Hendriks; Gopal Thinakaran; C L Harris; Chris De Jonghe; Jean-Jacques Martin; Sangram S Sisodia; Christine Van Broeckhoven
Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls.
Neuroreport 1997;8(7):1717-21.
1997: B Mahieu; Daniel Souery; O Lipp; K Mendelbaum; Greta Verheyen; V De Maertelaer; Christine Van Broeckhoven; Julien Mendlewicz
No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism.
Psychiatry research 1997;70(2):65-9.
1997: Stephan J Claes; Petra Raeymaekers; Marleen Van den Broeck; S Diependaele; A De bruyn; Greta Verheyen; V Wils; Andrea Boogaerts; An Tanghe; Jan Godderis; Christine Van Broeckhoven; Jean-Jacques Cassiman
A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder.
Journal of affective disorders 1997;43(3):195-205.
1997: Marjolijn Bornebroek; Joost Haan; Sjoerd G van Duinen; Marion L C Maat-Schieman; Mark A Van Buchem; Egbert Bakker; Christine Van Broeckhoven; Raymund A C Roos
Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype.
Annals of neurology 1997;41(5):695-8.
1997: Florian Stögbauer; P Young; Vincent Timmerman; P Spoelders; E Bernd Ringelstein; Christine Van Broeckhoven; Gerhard Kurlemann
Refinement of the hereditary neuralgic amyotrophy (HNA) locus to chromosome 17q24-q25.
Human genetics 1997;99(5):685-7.
1997: Lilijana Oruc; Greta Verheyen; I Furac; M Jakovljević; S Ivezić; Petra Raeymaekers; Christine Van Broeckhoven
Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients.
American journal of medical genetics 1997;74(2):176-8.
1997: A J C Slooter; Ming-Xin Tang; C.M. Duijn; Yaakov Stern; A Ott; Karen Bell; Monique Breteler; Christine Van Broeckhoven; TK Tatemichi; Benjamin Tycko; Albert Hofman; Richard Mayeux
Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.
JAMA : the journal of the American Medical Association 1997;277(10):818-21.
1997: Lilijana Oruc; Kerstin Lindblad; Greta Verheyen; S Ahlberg; M Jakovljević; S Ivezić; Petra Raeymaekers; Christine Van Broeckhoven; Martin Schalling
CAG repeat expansions in bipolar and unipolar disorders.
American journal of human genetics 1997;60(3):730-2.
1997: J Beuten; Els De Vriendt; Peter De Jonghe; Jean-Jacques Martin; Christine Van Broeckhoven; Vincent Timmerman
Mutation analysis of the human pancreatic phospholipase A2 gene in a family with distal hereditary motor neuropathy type II linked to 12q24.
Neuroscience letters 1997;223(1):69-71.
1997: Luc Krols; Jean-Jacques Martin; G David; Nicole Van Regemorter; Ali Benomar; Ann Löfgren; Giovanni Stevanin; A Dürr; Alexis Brice; Christine Van Broeckhoven
Refinement of the locus for autosomal dominant cerebellar ataxia type II to chromosome 3p21.1-14.1.
Human genetics 1997;99(2):225-32.
1997: Albert Hofman; Alewijn Ott; Monique Breteler; Michiel Bots; A J C Slooter; Frans van Harskamp; C.M. Duijn; Christine Van Broeckhoven; Diederick Grobbee
Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study.
Lancet 1997;349(9046):151-4.
1997: Peter De Jonghe; Vincent Timmerman; Eva Nelis; Jean-Jacques Martin; Christine Van Broeckhoven
Charcot-Marie-Tooth disease and related peripheral neuropathies.
Journal of the peripheral nervous system : JPNS 1997;2(4):370-87.
1997: Julie R Korenberg; Jaakko Aaltonen; C Brahe; Deborah E Cabin; N Creau; Jean-Maurice Delabar; J Doering; Katheleen Gardiner; RS Hubert; JH Ives; AM Kessling; J Kudoh; R Lafrenière; Y Murakami; M Ohira; M Ohki; D Patterson; Marie-Claude Potier; John Quackenbush; Roger H Reeves; Y Sakaki; N Shimizu; E Soeda; Christine Van Broeckhoven; Marie-Laure Yaspo
Report and abstracts of the Sixth International Workshop on Human Chromosome 21 Mapping 1996. Cold Spring Harbor, New York, USA. May 6-8,1996.
Cytogenetics and cell genetics 1997;79(1-2):21-52.
1997: Hans Werner Müller; U Suter; Christine Van Broeckhoven; C Oliver Hanemann; Eva Nelis; Vincent Timmerman; S Sancho; L Barrio; P Bolhuis; R Dermietzel; M Frank; A A W M Gabreëls-Festen; C Gillen; N Haites; G Levi; Edwin C M Mariman; R Martini; K Nave; Bernd Rautenstrauss; M Schachner; A Schenone; C Schneider; M Schröder; Klaus Willecke; O Haneman
Advances in Charcot-Marie-Tooth disease research: cellular function of CMT-related proteins, transgenic animal models, and pathomechanisms. The European CMT Consortium.
Neurobiology of disease 1997;4(3-4):215-20.
1997: Lilijana Oruc; Greta Verheyen; I Furac; S Ivezić; M Jakovljević; Petra Raeymaekers; Christine Van Broeckhoven
Positive association between the GABRA5 gene and unipolar recurrent major depression.
Neuropsychobiology 1997;36(2):62-4.
1997: Samir Kumar-Singh; Kurt Segers; U Rodeck; Hubert Backhovens; Johannes J P M Bogers; Joost Weyler; Christine Van Broeckhoven; Eric Van Marck
WT1 mutation in malignant mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression, cell-type transition, and prognosis.
The Journal of pathology 1997;181(1):67-74.
1997: Vincent Timmerman; Bernd Rautenstrauss; Lawrence Reiter; T Koeuth; Ann Löfgren; Thomas Liehr; Eva Nelis; KD Bathke; Peter De Jonghe; H Grehl; Jean-Jacques Martin; James R Lupski; Christine Van Broeckhoven
Detection of the CMT1A/HNPP recombination hotspot in unrelated patients of European descent.
Journal of medical genetics 1997;34(1):43-9.
1997: Eva Nelis; S Simokovic; Vincent Timmerman; Ann Löfgren; Hubert Backhovens; Peter De Jonghe; Jean-Jacques Martin; Christine Van Broeckhoven
Mutation analysis of the connexin 32 (Cx32) gene in Charcot-Marie-Tooth neuropathy type 1: identification of five new mutations.
Human mutation 1997;9(1):47-52.
1997: E Nelis; B Holmberg; R Adolfsson; G Holmgren; Christine Van Broeckhoven
PMP22 Thr(118)Met: recessive CMT1 mutation or polymorphism?
Nature genetics 1997;15(1):13-4.
1996: Daniel Souery; O Lipp; B Mahieu; K Mendelbaum; V De Martelaer; Christine Van Broeckhoven; Julien Mendlewicz
Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes.
American journal of medical genetics 1996;67(6):551-5.
1996: Françoise Chapon; P Diraison; B Lechevalier; G Chazot; Fausto Viader; C Bonnebouche; Antoon Vandenberghe; V Timmerman; Christine Van Broeckhoven; A Vandenberghe
Hereditary neuropathy with liability to pressure palsies with a partial deletion of the region often duplicated in Charcot-Marie-Tooth disease, type 1A.
Journal of neurology, neurosurgery, and psychiatry 1996;61(5):535-6.
1996: K G Monsieurs; Christine Van Broeckhoven; Jean-Jacques Martin; I Dehaene; Luc Heytens
Malignant hyperthermia susceptibility in a patient with concomitant motor neuron disease.
Journal of the neurological sciences 1996;142(1-2):36-8.
1996: LE Warner; M J Hilz; S H Appel; J M Killian; E H Kolodry; G Karpati; S Carpenter; G V Watters; C Wheeler; D Witt; A Bodell; Eva Nelis; Christine Van Broeckhoven; James R Lupski
Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination.
Neuron 1996;17(3):451-60.
1996: A A W M Gabreëls-Festen; Jessica E Hoogendijk; P H Meijerink; Fons J M Gabreëls; PA Bolhuis; Sylvia van Beersum; T Kulkens; Eva Nelis; F G I Jennekens; Marianne De Visser; B G M van Engelen; Christine Van Broeckhoven; Edwin C M Mariman
Two divergent types of nerve pathology in patients with different P0 mutations in Charcot-Marie-Tooth disease.
Neurology 1996;47(3):761-5.
1996: V S Rao; A Cupples; C.M. Duijn; Alexander Kurz; R C Green; H Chui; Ranjan Duara; S A Auerbach; Ladislav Volicer; J Wells; Christine Van Broeckhoven; John H Growdon; Jonathan L Haines; Lindsay A Farrer
Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4.
American journal of human genetics 1996;59(3):664-75.
1996: Daniel Souery; O Lipp; B Mahieu; K Mendelbaum; A De Bruyn; V De Maertelaer; Christine Van Broeckhoven; Julien Mendlewicz
Excess tyrosine hydroxylase restriction fragment length polymorphism homozygosity in unipolar but not bipolar patients: a preliminary report.
Biological psychiatry 1996;40(4):305-8.
1996: A J C Slooter; Monique Breteler; Alewijn Ott; Christine Van Broeckhoven; C.M. Duijn
APOE genotyping in differential diagnosis of Alzheimer's disease.
Lancet 1996;348(9023):334.
1996: Vincent Timmerman; Peter De Jonghe; S Simokovic; Ann Löfgren; J Beuten; Eva Nelis; Chantal Ceuterick; Jean-Jacques Martin; Christine Van Broeckhoven
Distal hereditary motor neuropathy type II (distal HMN II): mapping of a locus to chromosome 12q24.
Human molecular genetics 1996;5(7):1065-9.
1996: J Bronzova; C.M. Duijn; L M Havekes; P de Knijff; Christine Van Broeckhoven; Albert Hofman
Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease.
Journal of neurology 1996;243(6):465-8.
1996: Marcello Villanova; Alessandro Malandrini; R Biancotti; A Löfgren; Tiziana Mongini; J Six; R Salvestroni; E Parrotta; Christine Van Broeckhoven; C Paolozzi; Gianni Guazzi
Muscular dystrophy, mental retardation and cardiomyopathy not associated with dystrophin deficiency.
Neuromuscular disorders : NMD 1996;6(3):167-72.
1996: A Quattrone; A Gambardella; Francesco Bono; Umberto Aguglia; Alessandra Bolino; A C Bruni; M P Montesi; RL Oliveri; M Sabatelli; O Tamburrini; Paola Valentino; Christine Van Broeckhoven; Mario Zappia
Autosomal recessive hereditary motor and sensory neuropathy with focally folded myelin sheaths: clinical, electrophysiologic, and genetic aspects of a large family.
Neurology 1996;46(5):1318-24.
1996: Vincent Timmerman; Peter De Jonghe; P Spoelders; S Simokovic; Ann Löfgren; Eva Nelis; Jeffery Vance; Jean-Jacques Martin; Christine Van Broeckhoven
Linkage and mutation analysis of Charcot-Marie-Tooth neuropathy type 2 families with chromosomes 1p35-p36 and Xq13.
Neurology 1996;46(5):1311-8.
1996: A De Bruyn; Daniel Souery; K Mendelbaum; Julien Mendlewicz; Christine Van Broeckhoven
Linkage analysis of families with bipolar illness and chromosome 18 markers.
Biological psychiatry 1996;39(8):679-88.
1996: L Hendriks; Christine Van Broeckhoven
A beta A4 amyloid precursor protein gene and Alzheimer's disease.
European journal of biochemistry / FEBS 1996;237(1):6-15.
1996: Lilijana Oruc; I Furac; C Croux; Miro Jakovljevic; I Kracun; V Folnegović; Christine Van Broeckhoven
Association study between bipolar disorder and candidate genes involved in dopamine-serotonin metabolism and GABAergic neurotransmission: a preliminary report.
Psychiatric genetics 1996;6(4):213-7.
1996: Eva Nelis; L E Warner; E D Vriendt; Phillip F Chance; James R Lupski; Christine Van Broeckhoven
Comparison of single-strand conformation polymorphism and heteroduplex analysis for detection of mutations in Charcot-Marie-Tooth type 1 disease and related peripheral neuropathies.
European journal of human genetics : EJHG 1996;4(6):329-33.
1996: K Silander; P Meretoja; Eva Nelis; Vincent Timmerman; Christine Van Broeckhoven; Pertti Aula; Marja-Liisa Savontaus
A de novo duplication in 17p11.2 and a novel mutation in the Po gene in two Déjérine-Sottas syndrome patients.
Human mutation 1996;8(4):304-10.
1996: Peter De Jonghe; Luc Krols; Andrej Michalik; J Hazan; G Smeyers; Ann Löfgren; J Weissenbach; Jean-Jacques Martin; Christine Van Broeckhoven
Pure familial spastic paraplegia: clinical and genetic analysis of nine Belgian pedigrees.
European journal of human genetics : EJHG 1996;4(5):260-6.
1996: L Hendriks; Patrick Cras; Jean-Jacques Martin; Christine Van Broeckhoven
Beta-amyloid precursor protein and early-onset Alzheimer's disease.
Ciba Foundation symposium 1996;199():170-80.
1996: Marc Cruts; L Hendriks; Christine Van Broeckhoven
The presenilin genes: a new gene family involved in Alzheimer disease pathology.
Human molecular genetics 1996;5 Spec No():1449-55.
1996: A De Bruyn; Daniel Souery; K Mendelbaum; Julien Mendlewicz; Christine Van Broeckhoven
A linkage study between bipolar disorder and genes involved in dopaminergic and GABAergic neurotransmission.
Psychiatric genetics 1996;6(2):67-73.
1996: Eva Nelis; Christine Van Broeckhoven; Peter De Jonghe; Ann Löfgren; Antoon Vandenberghe; Philippe Latour; E Le Guern; Alexis Brice; Maria Luisa Mostacciuolo; Franco Schiavon; Francesc Palau; S Bort; M Upadhyaya; M Rocchi; N Archidiacono; Paola Mandich; Emilia Bellone; K Silander; Marja-Liisa Savontaus; Ruth Navon; H Goldberg-Stern; X Estivill; V Volpini; W Friedl; A Gal
Estimation of the mutation frequencies in Charcot-Marie-Tooth disease type 1 and hereditary neuropathy with liability to pressure palsies: a European collaborative study.
European journal of human genetics : EJHG 1996;4(1):25-33.
1996: Emilia Bellone; Paola Mandich; R James; Eva Nelis; L D Lamba; Christine Van Broeckhoven; Franco Ajmar
Identification of a 4 bp deletion (1560del4) in po gene in a family with severe Charcot-Marie-Tooth disease.
Human mutation 1996;7(4):377-8.
1996: Vincent Timmerman; Ann Löfgren; E Le Guern; P Liang; Peter De Jonghe; Jean-Jacques Martin; D Verhalle; Wim Robberecht; Riadh Gouider; Alexis Brice; Christine Van Broeckhoven
Molecular genetic analysis of the 17p11.2 region in patients with hereditary neuropathy with liability to pressure palsies (HNPP).
Human genetics 1996;97(1):26-34.
1995: Christine Van Broeckhoven
Presenilins and Alzheimer disease.
Nature genetics 1995;11(3):230-2.
1995: William S Brooks; Ralph N Martins; J De Voecht; Garth A Nicholson; Peter R Schofield; John B J Kwok; C Fisher; L U Yeung; Christine Van Broeckhoven
A mutation in codon 717 of the amyloid precursor protein gene in an Australian family with Alzheimer's disease.
Neuroscience letters 1995;199(3):183-6.
1995: Marc Cruts; Hubert Backhovens; Jessie Theuns; Robert Clark; D Le Paslier; J Weissenbach; Alison Goate; Jean-Jacques Martin; Christine Van Broeckhoven
Genetic and physical characterization of the early-onset Alzheimer's disease AD3 locus on chromosome 14q24.3.
Human molecular genetics 1995;4(8):1355-64.
1995: Robert Clark; Marc Cruts; Kevin Korenblat; C He; C Talbot; Christine Van Broeckhoven; Alison Goate
A yeast artificial chromosome contig from human chromosome 14q24 spanning the Alzheimer's disease locus AD3.
Human molecular genetics 1995;4(8):1347-54.
1995: R James; Emilia Bellone; Eva Nelis; Paola Mandich; Angelo Schenone; G Mancardi; Christine Van Broeckhoven; Michele Abbruzzese; Franco Ajmar
Molecular analysis of three cases with hereditary motor and sensory neuropathy with myelin outfolding.
Neuroscience letters 1995;194(1-2):136-8.
1995: Ruth Navon; Vincent Timmerman; Ann Löfgren; P Liang; Eva Nelis; M Zeitune; Christine Van Broeckhoven
Prenatal diagnosis of Charcot-Marie-Tooth disease type 1A (CMT1A) using molecular genetic techniques.
Prenatal diagnosis 1995;15(7):633-40.
1995: C.M. Duijn; P de Knijff; A Wehnert; J De Voecht; J B Bronzova; L M Havekes; Albert Hofman; Christine Van Broeckhoven
The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival.
Annals of neurology 1995;37(5):605-10.
1995: J Liu; Willy Lissens; Christine Van Broeckhoven; Ann Löfgren; Michel Camus; Inge Liebaers; André Van Steirteghem
Normal pregnancy after preimplantation DNA diagnosis of a dystrophin gene deletion.
Prenatal diagnosis 1995;15(4):351-8.
1995: C.M. Duijn; L M Havekes; Christine Van Broeckhoven; P de Knijff; Albert Hofman
Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease.
BMJ (Clinical research ed.) 1995;310(6980):627-31.
1995: R Sudbrak; V Procaccio; M Klausnitzer; JL Curran; Koenraad G Monsieurs; Christine Van Broeckhoven; R Ellis; L Heyetens; Edmund J Hartung; G Kozak-Ribbens
Mapping of a further malignant hyperthermia susceptibility locus to chromosome 3q13.1.
American journal of human genetics 1995;56(3):684-91.
1995: P Gosset; N Crété; G Ait Ghezala; D Théophile; Christine Van Broeckhoven; C Vayssettes; Pierre-Marie Sinet; Nicole Créau
A high-resolution map of 1.6 Mb in the Down syndrome region: a new map between D21S55 and ETS2.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(2):127-30.
1995: Kurt Segers; Hubert Backhovens; S K Singh; J De Voecht; Marc Ramael; Christine Van Broeckhoven; Eric Van Marck
Immunoreactivity for p53 and mdm2 and the detection of p53 mutations in human malignant mesothelioma.
Virchows Archiv : an international journal of pathology 1995;427(4):431-6.
1995: K Mendelbaum; Serge Sevy; Daniel Souery; George N Papadimitriou; A De Bruyn; Petra Raeymaekers; Christine Van Broeckhoven; Julien Mendlewicz
Manic-depressive illness and linkage reanalysis in the Xq27-Xq28 region of chromosome X.
Neuropsychobiology 1995;31(2):58-63.
1995: Christine Van Broeckhoven
Molecular genetics of Alzheimer disease: identification of genes and gene mutations.
European neurology 1995;35(1):8-19.
1994: A De Bruyn; Petra Raeymaekers; K Mendelbaum; Lodewijk A Sandkuijl; G Raes; V Delvenne; D Hirsch; Luc Staner; Julien Mendlewicz; Christine Van Broeckhoven
Linkage analysis of bipolar illness with X-chromosome DNA markers: a susceptibility gene in Xq27-q28 cannot be excluded.
American journal of medical genetics 1994;54(4):411-9.
1994: Eva Nelis; Vincent Timmerman; Peter De Jonghe; Antoon Vandenberghe; Danielle Pham-Dinh; André Dautigny; Jean-Jacques Martin; Christine Van Broeckhoven
Rapid screening of myelin genes in CMT1 patients by SSCP analysis: identification of new mutations and polymorphisms in the P0 gene.
Human genetics 1994;94(6):653-7.
1994: G Vanhoof; Filip Goossens; L Hendriks; I De Meester; Dirk F Hendriks; G Vriend; Christine Van Broeckhoven; S Scharpé
Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase.
Gene 1994;149(2):363-6.
1994: C.M. Duijn; L Hendriks; Lindsay A Farrer; Hubert Backhovens; Marc Cruts; A Wehnert; Albert Hofman; Christine Van Broeckhoven
A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21.
American journal of human genetics 1994;55(4):714-27.
1994: Eva Nelis; Vincent Timmerman; Peter De Jonghe; L Muylle; Jean-Jacques Martin; Christine Van Broeckhoven
Linkage and mutation analysis in an extended family with Charcot-Marie-Tooth disease type 1B.
Journal of medical genetics 1994;31(10):811-5.
1994: Joost Haan; Christine Van Broeckhoven; C.M. Duijn; E Voorhoeve; Frans van Harskamp; John C van Swieten; Marion L C Maat-Schieman; Raymund A C Roos; Egbert Bakker
The apolipoprotein E epsilon 4 allele does not influence the clinical expression of the amyloid precursor protein gene codon 693 or 692 mutations.
Annals of neurology 1994;36(3):434-7.
1994: Bernd Rautenstrauss; Eva Nelis; H Grehl; R A Pfeiffer; Christine Van Broeckhoven
Identification of a de novo insertional mutation in P0 in a patient with a Déjérine-Sottas syndrome (DSS) phenotype.
Human molecular genetics 1994;3(9):1701-2.
1994: A Dutriaux; Jean Rossier; Wim Van Hul; Dean Nizetic; D Theophille; Jean-Maurice Delabar; Christine Van Broeckhoven; Marie-Claude Potier
Cloning and characterization of a 135- to 500-kb region of homology on the long arm of human chromosome 21.
Genomics 1994;22(2):472-7.
1994: Marc Cruts; Hubert Backhovens; Jean-Jacques Martin; Christine Van Broeckhoven
Genetic analysis of the cellular oncogene fos in patients with chromosome 14 encoded Alzheimer's disease.
Neuroscience letters 1994;174(1):97-100.
1994: D Verhalle; Ann Löfgren; Eva Nelis; I Dehaene; P Theys; M Lammens; R Dom; Christine Van Broeckhoven; Wim Robberecht
Deletion in the CMT1A locus on chromosome 17p11.2 in hereditary neuropathy with liability to pressure palsies.
Annals of neurology 1994;35(6):704-8.
1994: T C Matise; Aravinda Chakravarti; Pragna I Patel; James R Lupski; Eva Nelis; Vincent Timmerman; Christine Van Broeckhoven; Daniel E Weeks
Detection of tandem duplications and implications for linkage analysis.
American journal of human genetics 1994;54(6):1110-21.
1994: B H Holmberg; Gösta Holmgren; E Nelis; Christine Van Broeckhoven; B Westerberg
Charcot-Marie-Tooth disease in northern Sweden: pedigree analysis and the presence of the duplication in chromosome 17p11.2.
Journal of medical genetics 1994;31(6):435-41.
1994: C.M. Duijn; P de Knijff; Marc Cruts; A Wehnert; L M Havekes; Albert Hofman; Christine Van Broeckhoven
Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease.
Nature genetics 1994;7(1):74-8.
1994: C Oliver Hanemann; Guido Stoll; D D'Urso; W Fricke; J J Martin; Christine Van Broeckhoven; G L Mancardi; I Bartke; Hans Werner Müller
Peripheral myelin protein-22 expression in Charcot-Marie-Tooth disease type 1a sural nerve biopsies.
Journal of neuroscience research 1994;37(5):654-9.
1994: Christine Van Broeckhoven; Hubert Backhovens; Marc Cruts; Jean-Jacques Martin; Richard Crook; Henry Houlden; John Hardy
APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.
Neuroscience letters 1994;169(1-2):179-80.
1994: Eva Nelis; Vincent Timmerman; Peter De Jonghe; Christine Van Broeckhoven
Identification of a 5' splice site mutation in the PMP-22 gene in autosomal dominant Charcot-Marie-Tooth disease type 1.
Human molecular genetics 1994;3(3):515-6.
1994: A De Bruyn; K Mendelbaum; Lodewijk A Sandkuijl; V Delvenne; D Hirsch; Luc Staner; Julien Mendlewicz; Christine Van Broeckhoven
Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11.
The American journal of psychiatry 1994;151(1):102-6.
1994: Christine Van Broeckhoven
Genes in early onset Alzheimer's disease: implications for AD research.
Neurobiology of aging 1994;15 Suppl 2():S149-53.
1993: Francesc Palau; Ann Löfgren; Peter De Jonghe; S Bort; Eva Nelis; Teresa Sevilla; J J Martin; J Vilchez; Félix Prieto; Christine Van Broeckhoven
Origin of the de novo duplication in Charcot-Marie-Tooth disease type 1A: unequal nonsister chromatid exchange during spermatogenesis.
Human molecular genetics 1993;2(12):2031-5.
1993: P Willems; Lieve Vits; I Buntinx; Petra Raeymaekers; Christine Van Broeckhoven; B Ceulemans
Localization of a gene responsible for nonspecific mental retardation (MRX9) to the pericentromeric region of the X chromosome.
Genomics 1993;18(2):290-4.
1993: Wim Van Hul; Guy Van Camp; Lieven Stuyver; Jean-Maurice Delabar; Melvin G McInnis; AC Warren; S E Antonarakis; Christine Van Broeckhoven
A contiguous physical map of the pericentromeric region of chromosome 21q between D21Z1 and D21S13E.
Genomics 1993;15(3):626-30.
1993: J Beuten; Kathelijne Mangelschots; I Buntinx; P Coucke; Oebele F Brouwer; Raoul Hennekam; Christine Van Broeckhoven; Patrick J Willems
Molecular study of chromosome 15 in 22 patients with Angelman syndrome.
Human genetics 1993;90(5):489-95.
1993: Jean-Jacques Martin; Chantal Ceuterick; Ursula Lübke; Christine Van Broeckhoven
Duchenne muscular dystrophy immunohistochemistry of foetal muscles.
Acta neurologica Belgica 1993;93(3):130-8.
1992: Christine Van Broeckhoven; Hubert Backhovens; Marc Cruts; G De Winter; M Bruyland; Patrick Cras; Jean-Jacques Martin
Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3.
Nature genetics 1992;2(4):335-9.
1992: M B Peterson; M Frantzen; S E Antonarakis; AC Warren; Christine Van Broeckhoven; Aravinda Chakravarti; T K Cox; C Lund; B Olsen; H Poulsen
Comparative study of microsatellite and cytogenetic markers for detecting the origin of the nondisjoined chromosome 21 in Down syndrome.
American journal of human genetics 1992;51(3):516-25.
1992: A Wehnert; Marc Cruts; Hubert Backhovens; Jean-Maurice Delabar; G Thomas; Christine Van Broeckhoven
Dinucleotide repeat polymorphism at the D21S258 locus.
Human molecular genetics 1992;1(6):449.
1992: Patrick J Willems; Lieve Vits; Petra Raeymaekers; J Beuten; P Coucke; J J Holden; Christine Van Broeckhoven; Stephen Warren; M Sagi; D Robinson
Further localization of X-linked hydrocephalus in the chromosomal region Xq28.
American journal of human genetics 1992;51(2):307-15.
1992: AC Warren; Michael B Petersen; Wim Van Hul; Melvin G McInnis; Christine Van Broeckhoven; T K Cox; Aravinda Chakravarti; S E Antonarakis
D21S215 is a (GT)n polymorphic marker close to centromeric alphoid sequences on chromosome 21.
Genomics 1992;13(4):1365-7.
1992: Jessica E Hoogendijk; G W Hensels; A A W M Gabreëls-Festen; Fons J M Gabreëls; Emiel Janssen; Peter De Jonghe; J J Martin; Christine Van Broeckhoven; Linda J Valentijn; F Baas
De-novo mutation in hereditary motor and sensory neuropathy type I.
Lancet 1992;339(8801):1081-2.
1992: Vincent Timmerman; Petra Raeymaekers; Eva Nelis; Peter De Jonghe; L Muylle; Chantal Ceuterick; Jean-Jacques Martin; Christine Van Broeckhoven
Linkage analysis of distal hereditary motor neuropathy type II (distal HMN II) in a single pedigree.
Journal of the neurological sciences 1992;109(1):41-8.
1992: Siegfried Uhlhaas; E Bakker; Christine Van Broeckhoven; A Barth-Schulz; Waltraut Friedl
A rare MspI RFLP of the DMD probe p20 (DXS269).
Human genetics 1992;89(1):122.
1992: Marc Cruts; Hubert Backhovens; Christine Van Broeckhoven
Dinucleotide repeat polymorphism at the D21S16 [correction of D1S16] locus.
Nucleic acids research 1992;20(5):1159.
1992: Marc Cruts; Hubert Backhovens; Christine Van Broeckhoven
Dinucleotide repeat polymorphism at the D21S145 locus.
Nucleic acids research 1992;20(5):1159.
1992: Guy Van Camp; Marc Cruts; Hubert Backhovens; A Wehnert; Christine Van Broeckhoven
Unique sequence homology in the pericentromeric regions of the long arms of chromosomes 13 and 21.
Genomics 1992;12(1):158-60.
1992: Anthonie J van Essen; Stephen Abbs; M Baiget; Egbert Bakker; catherine boileau; Christine Van Broeckhoven; K Bushby; A Clarke; M Claustres; A E Covone
Parental origin and germline mosaicism of deletions and duplications of the dystrophin gene: a European study.
Human genetics 1992;88(3):249-57.
1992: Petra Raeymaekers; Vincent Timmerman; Eva Nelis; Wim Van Hul; Peter De Jonghe; Jean-Jacques Martin; Christine Van Broeckhoven
Estimation of the size of the chromosome 17p11.2 duplication in Charcot-Marie-Tooth neuropathy type 1a (CMT1a). HMSN Collaborative Research Group.
Journal of medical genetics 1992;29(1):5-11.
1992: Jean-Jacques Martin; J Leroy; Chantal Ceuterick; Ursula Lübke; E Van Buggenhout; J Van Vuchelen; Christine Van Broeckhoven
Becker-type muscular dystrophy. Report of a family with one postmortem study.
Clinical neurology and neurosurgery 1992;94 Suppl():S123-6.
1991: Julien Mendlewicz; Marion Leboyer; A De Bruyn; Alain Malafosse; Serge Sevy; D Hirsch; Christine Van Broeckhoven; J Mallet
Absence of linkage between chromosome 11p15 markers and manic-depressive illness in a Belgian pedigree.
The American journal of psychiatry 1991;148(12):1683-7.
1991: Guy Van Camp; Hubert Backhovens; Marc Cruts; A Wehnert; Wim Van Hul; P Stinissen; Christine Van Broeckhoven
Identification of chromosome 21 DNA polymorphisms for genetic studies in Alzheimer's disease and Down syndrome.
Human genetics 1991;87(6):649-53.
1991: P Stinissen; Christine Van Broeckhoven
A new (CA)n repeat polymorphism at the D21S13E locus.
Nucleic acids research 1991;19(18):5089.
1991: Egbert Bakker; Christine Van Broeckhoven; Joost Haan; E Voorhoeve; Wim Van Hul; Efrat Levy; I Lieberburg; M D Carman; Gert-Jan B van Ommen; Blas Frangione
DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type)
American journal of human genetics 1991;49(3):518-21.
1991: Marie-Christine Chartier-Harlin; Fiona Crawford; K Hamandi; Michael Mullan; Alison Goate; John Hardy; Hubert Backhovens; J J Martin; Christine Van Broeckhoven
Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.
Neuroscience letters 1991;129(1):134-5.
1991: L A Blonden; P M Grootscholten; Johan T den Dunnen; Egbert Bakker; Stephen Abbs; Martin Bobrow; Corinne D Boehm; Christine Van Broeckhoven; Lisa Baumbach; J Chamberlain
242 breakpoints in the 200-kb deletion-prone P20 region of the DMD gene are widely spread.
Genomics 1991;10(3):631-9.
1991: Wim Van Hul; Hubert Backhovens; Guy Van Camp; P Stinissen; Marc Cruts; A Wehnert; Christine Van Broeckhoven
Subregional localization of the chromosome 21 loci D21S24 and D21S26 using physical mapping techniques.
Human genetics 1991;87(2):109-11.
1991: P Stinissen; Christine Van Broeckhoven
PCR detection of the frequent TaqI RFLP at locus D21S13E.
Nucleic acids research 1991;19(9):2516.
1991: C.M. Duijn; L Hendriks; Marc Cruts; John Hardy; Albert Hofman; Christine Van Broeckhoven
Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.
Lancet 1991;337(8747):978.
1991: C.M. Duijn; Christine Van Broeckhoven; John Hardy; Alison Goate; Martin N Rossor; A Vandenberghe; J J Martin; Albert Hofman; Michael Mullan
Evidence for allelic heterogeneity in familial early-onset Alzheimer's disease.
The British journal of psychiatry : the journal of mental science 1991;158():471-4.
1991: J Mendlewicz; L A Sandkuil; A De Bruyn; Christine Van Broeckhoven
X-linkage in bipolar illness.
Biological psychiatry 1991;29(7):730-1.
1991: Patrick J Willems; Jan Hendrickx; B J Van der Auwera; Lieve Vits; Petra Raeymaekers; Paul J Coucke; I Van den Bergh; R Berger; G Peter A Smit; Christine Van Broeckhoven
Mapping of the gene for X-linked liver glycogenosis due to phosphorylase kinase deficiency to human chromosome region Xp22.
Genomics 1991;9(4):565-9.
1991: Raymund A C Roos; Joost Haan; Christine Van Broeckhoven
Hereditary cerebral hemorrhage with amyloidosis--Dutch type: a congophilic angiopathy. An overview.
Annals of the New York Academy of Sciences 1991;640():155-60.
1990: Vincent Timmerman; Petra Raeymaekers; Peter De Jonghe; G De Winter; L Swerts; K Jacobs; J Gheuens; Jean-Jacques Martin; Antoon Vandenberghe; Christine Van Broeckhoven
Assignment of the Charcot-Marie-Tooth neuropathy type 1 (CMT 1a) gene to 17p11.2-p12.
American journal of human genetics 1990;47(4):680-5.
1990: Patrick J Willems; I Dijkstra; B J Van der Auwera; Lieve Vits; P Coucke; Petra Raeymaekers; Christine Van Broeckhoven; G Giacomo Consalez; S B Freeman; Stephen Warren
Assignment of X-linked hydrocephalus to Xq28 by linkage analysis.
Genomics 1990;8(2):367-70.
1990: Peter St George-Hyslop; Jonathan L Haines; Lindsay A Farrer; R Polinsky; Christine Van Broeckhoven; Alison Goate; D R McLachlan; H Orr; A C Bruni; Sandro Sorbi; I Rainero; J F Foncin; D Pollen; J M Cantu; R Tupler; N Voskresenskaya; Richard Mayeux; J Growden; V A Fried; Richard H Myers; L Nee; H Backhovens; J J Martin; Martin N Rossor; Michael J Owen; Michael Mullan; M E Percy; H Karlinsky; S Rich; L Heston; M Montesi; M Mortilla; N Nacmias; James Gusella; John Hardy
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
Nature 1990;347(6289):194-7.
1990: P Stinissen; Antoon Vandenberghe; Christine Van Broeckhoven
PCR detection of two RFLP's at the D21S13 locus.
Nucleic acids research 1990;18(12):3672.
1990: Patrick J Willems; Lieve Vits; R J Wanders; Paul J Coucke; B J Van der Auwera; A F Van Elsen; Petra Raeymaekers; Christine Van Broeckhoven; R B Schutgens; G Dacremont
Linkage of DNA markers at Xq28 to adrenoleukodystrophy and adrenomyeloneuropathy present within the same family.
Archives of neurology 1990;47(6):665-9.
1990: Christine Van Broeckhoven; J Haan; Egbert Bakker; John Hardy; Wim Van Hul; A Wehnert; M Vegter-Van der Vlis; Raymund A C Roos
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).
Science (New York, N.Y.) 1990;248(4959):1120-2.
1990: Guy Van Camp; Antoon Vandenberghe; Christine Van Broeckhoven
An informative MspI polymorphism detected at the D21S16 locus.
Human genetics 1990;85(1):140.
1990: Guy Van Camp; Wim Van Hul; Hubert Backhovens; P Stinissen; A Wehnert; D Patterson; Antoon Vandenberghe; Christine Van Broeckhoven
Physical mapping of chromosome 21 DNA markers in Alzheimer's disease region using somatic cell hybrids.
Somatic cell and molecular genetics 1990;16(3):241-9.
1990: P Stinissen; Wim Van Hul; Guy Van Camp; Hubert Backhovens; A Wehnert; Antoon Vandenberghe; Christine Van Broeckhoven
The pericentromeric 21 DNA marker pGSM21 (D21S13) contains an expressed HTF island.
Genomics 1990;7(1):119-22.
1990: P Stinissen; Antoon Vandenberghe; Christine Van Broeckhoven
A high frequency EcoRI RFLP detected at the D21S13 locus.
Nucleic acids research 1990;18(5):1319.
1990: P Stinissen; B Van Roy; Guy Van Camp; Hubert Backhovens; PM Partoens; A Wehnert; H Verniers; J Dumon; Antoon Vandenberghe; Christine Van Broeckhoven
Study of the origin of nondisjunction in a family with two cases of Down syndrome using cytogenetic and molecular polymorphisms.
American journal of medical genetics. Supplement 1990;7():133-6.
1989: Petra Raeymaekers; Vincent Timmerman; Peter De Jonghe; L Swerts; J Gheuens; Jean-Jacques Martin; L Muylle; G De Winter; Antoon Vandenberghe; Christine Van Broeckhoven
Localization of the mutation in an extended family with Charcot-Marie-Tooth neuropathy (HMSN I).
American journal of human genetics 1989;45(6):953-8.
1989: Johan T den Dunnen; P M Grootscholten; Egbert Bakker; L A Blonden; HB Ginjaar; M C Wapenaar; H M van Paassen; Christine Van Broeckhoven; P L Pearson; Gert-Jan B van Ommen
Topography of the Duchenne muscular dystrophy (DMD) gene: FIGE and cDNA analysis of 194 cases reveals 115 deletions and 13 duplications.
American journal of human genetics 1989;45(6):835-47.
1989: Zwi N Berneman; Petra Raeymaekers; G Vanhoof; Dirk R Van Bockstaele; Marc Ramael; M E Peetermans; Antoon Vandenberghe; Christine Van Broeckhoven
DNA fingerprints revealing common and divergent human DNA methylation patterns.
FEBS letters 1989;255(2):226-30.
1989: Christine Van Broeckhoven
Molecular genetic analysis of early onset familial Alzheimer's disease.
Neurobiology of aging 1989;10(5):437-8; discussion 446-8.
1989: Egbert Bakker; H Veenema; Johan T den Dunnen; Christine Van Broeckhoven; P M Grootscholten; E J Bonten; Gert-Jan B van Ommen; P L Pearson
Germinal mosaicism increases the recurrence risk for 'new' Duchenne muscular dystrophy mutations.
Journal of medical genetics 1989;26(9):553-9.
1989: Guy Van Camp; P Stinissen; Wim Van Hul; Hubert Backhovens; A Wehnert; A Vandenberge; Christine Van Broeckhoven
Selection of human chromosome 21-specific DNA probes for genetic analysis in Alzheimer's dementia and Down syndrome.
Human genetics 1989;83(1):58-60.
1989: Guy Van Camp; P Stinissen; Antoon Vandenberghe; Christine Van Broeckhoven
A polymorphic locus [D21S144] is detected by probe pVC12 on chromosome 21.
Nucleic acids research 1989;17(11):4420.
1989: Petra Raeymaekers; Peter De Jonghe; Hubert Backhovens; A Wehnert; G De Winter; L Swerts; J Gheuens; Jean-Jacques Martin; Antoon Vandenberghe; Christine Van Broeckhoven
Absence of genetic linkage of Charcot-Marie-Tooth disease (HMSN Ia) with chromosome 1 gene markers.
Neurology 1989;39(6):844-6.
1989: A Vandenberghe; Christine Van Broeckhoven
[Genetic findings in degenerative dementia].
Acta neurologica Belgica 1989;89(3-4):194-7.
1989: A Vandenberghe; Christine Van Broeckhoven
[Genetic coupling study using DNA markers in the familial form of Alzheimer's disease].
Acta neurologica Belgica 1989;89(3-4):300-1.
1989: Petra Raeymaekers; Christine Van Broeckhoven; Antoon Vandenberghe
A polymorphic locus [D1S88] is detected by probe LA01.41 on chromosome 1p.
Nucleic acids research 1989;17(3):1278.
1989: Petra Raeymaekers; Christine Van Broeckhoven; Hubert Backhovens; A Wehnert; L Muylle; Peter De Jonghe; J Gheuens; Jean-Jacques Martin; Antoon Vandenberghe
Linkage analysis of the Duffy blood group marker with several chromosome 1 genes in an extended pedigree with Charcot-Marie-Tooth disease.
Human genetics 1989;81(3):231-3.
1989: Petra Raeymaekers; Peter De Jonghe; L Swerts; G De Winter; J Gheuens; Jean-Jacques Martin; Antoon Vandenberghe; Christine Van Broeckhoven
Exclusion analysis of Charcot-Marie-Tooth neuropathy (CMT1) with chromosome 1p markers.
Cytogenetics and cell genetics 1989;50(2-3):178-80.
1988: Petra Raeymaekers; Peter De Jonghe; L Swerts; L Muylle; J Gheuens; Jean-Jacques Martin; Christine Van Broeckhoven; Antoon Vandenberghe
Absence of linkage with the Duffy blood group in a family with Charcot-Marie-Tooth neuropathy.
Journal of the neurological sciences 1988;88(1-3):145-50.
1988: L Hendriks; Christine Van Broeckhoven; A Vandenberghe; Yves Van de Peer; Rupert De Wachter
Primary and secondary structure of the 18S ribosomal RNA of the bird spider Eurypelma californica and evolutionary relationships among eukaryotic phyla.
European journal of biochemistry / FEBS 1988;177(1):15-20.
1988: P Raeymaekers; Christine Van Broeckhoven; A Vandenberghe
A highly polymorphic locus is detected by probe CARLP II6.3 [D5S88].
Nucleic acids research 1988;16(16):8196.
1988: L Hendriks; Raymond De Baere; Christine Van Broeckhoven; Rupert De Wachter
Primary and secondary structure of the 18 S ribosomal RNA of the insect species Tenebrio molitor.
FEBS letters 1988;232(1):115-20.
1988: P Raeymaekers; Christine Van Broeckhoven; A Vandenberghe
Two polymorphic loci are detected simultaneously by probe CARLP II8.2 [D10S21] on chromosome 10.
Nucleic acids research 1988;16(6):2738.
1988: Petra Raeymaekers; Christine Van Broeckhoven; Hubert Backhovens; A Wehnert; L Muylle; Peter De Jonghe; J Gheuens; Antoon Vandenberghe
The Duffy blood group is linked to the alpha-spectrin locus in a large pedigree with autosomal dominant inheritance of Charcot-Marie-Tooth disease type 1.
Human genetics 1988;78(1):76-8.
1987: Egbert Bakker; Christine Van Broeckhoven; E J Bonten; M J van de Vooren; H Veenema; Wim Van Hul; Gert-Jan B van Ommen; Antoon Vandenberghe; P L Pearson
Germline mosaicism and Duchenne muscular dystrophy mutations.
Nature 1987;329(6139):554-6.
1987: Christine Van Broeckhoven; A M Genthe; Antoon Vandenberghe; B Horsthemke; Hubert Backhovens; Petra Raeymaekers; Wim Van Hul; A Wehnert; J Gheuens; Patrick Cras
Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families.
Nature 1987;329(6135):153-5.
1984: Luc Nelles; Christine Van Broeckhoven; R De Wachter; A Vandenberghe
Location of the hidden break in large subunit ribosomal RNA of Artemia salina.
Die Naturwissenschaften 1984;71(12):634-5.
1984: K Adriaenssens; D Karcher; B Marescau; Christine Van Broeckhoven; A Lowenthal; H C Terheggen
Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo.
The International journal of biochemistry 1984;16(7):779-86.
1982: Christine Van Broeckhoven; K M Adriaenssens; B Marescau; J Pintens; H G Terheggen
Measurement of arginine transport in human erythrocytes using their intrinsic arginase activity: implications for the treatment of familial hyperargininemia.
Clinica chimica acta; international journal of clinical chemistry 1982;126(3):209-16.
1979: A Vandenberghe; Christine Van Broeckhoven; R De Wachter
Separation of oligoribonucleotides by high performance liquid chromatography [proceedings].
Archives internationales de physiologie et de biochimie 1979;87(4):848-9.
1978: Christine Van Broeckhoven; R De Wachter
The reactions of mercurated pyrimidine nucleotides with thiols and with hydrogen sulfide.
Nucleic acids research 1978;5(6):2133-51.
1977: Christine Van Broeckhoven; R De Wachter
Synthesis and properties of 5-thiomercuri derivatives of pyrimidine nucleotides [proceedings].
Archives internationales de physiologie et de biochimie 1977;85(1):200-1.