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David Hone

Research Profile

Living Beings

Chemicals & Drugs

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Immunity, Mucosal

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Publications

TOP 3
Ronggai Sun; Yasir A W Skeiky; Angelo Izzo; Veerabadran Dheenadhayalan; Zakaria Imam; Erica Penn; Katherine Stagliano; Scott Haddock; Stefanie Mueller; John Fulkerson; Charles Scanga; Ajay Grover; Steven C Derrick; Sheldon Morris; David Hone; Marcus A Horwitz; Stefan H E Kaufmann; Jerald C Sadoff
Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis.
Katarina Radosevic; Catharina W Wieland; Ariane Rodriguez; Gerrit Jan Weverling; Ratna Mintardjo; Gert Gillissen; Ronald Vogels; Yasir A W Skeiky; David Hone; Jerald C Sadoff; Tom van der Poll; Menzo J E Havenga; Jaap Goudsmit
Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon.
Frank F Weichold; Stefanie Mueller; Cornelius Kortsik; Walter E Hitzler; M J Wulf; David Hone; Jerald C Sadoff; Markus J Maeurer
Impact of MHC class I alleles on the M. tuberculosis antigen-specific CD8+ T-cell response in patients with pulmonary tuberculosis.

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All Publications

2009: Ronggai Sun; Yasir A W Skeiky; Angelo Izzo; Veerabadran Dheenadhayalan; Zakaria Imam; Erica Penn; Katherine Stagliano; Scott Haddock; Stefanie Mueller; John Fulkerson; Charles Scanga; Ajay Grover; Steven C Derrick; Sheldon Morris; David Hone; Marcus A Horwitz; Stefan H E Kaufmann; Jerald C Sadoff
Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis.
Vaccine 2009;27(33):4412-23.
2007: Katarina Radosevic; Catharina W Wieland; Ariane Rodriguez; Gerrit Jan Weverling; Ratna Mintardjo; Gert Gillissen; Ronald Vogels; Yasir A W Skeiky; David Hone; Jerald C Sadoff; Tom van der Poll; Menzo J E Havenga; Jaap Goudsmit
Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon.
Infection and immunity 2007;75(8):4105-15.
2007: Frank F Weichold; Stefanie Mueller; Cornelius Kortsik; Walter E Hitzler; M J Wulf; David Hone; Jerald C Sadoff; Markus J Maeurer
Impact of MHC class I alleles on the M. tuberculosis antigen-specific CD8+ T-cell response in patients with pulmonary tuberculosis.
Genes and immunity 2007;8(4):334-43.
2006: Menzo J E Havenga; Ronald Vogels; David Zuijdgeest; Katarina Radosevic; Stefanie Mueller; M Sieuwerts; Frank F Weichold; Irma Damen; Jorn Kaspers; Angelique A C Lemckert; Michelle van Meerendonk; R van der Vlugt; Lennart Holterman; David Hone; Yasir A W Skeiky; Ratna Mintardjo; Gert Gillissen; Dan H Barouch; Jerald C Sadoff; Jaap Goudsmit
Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6 cells.
The Journal of general virology 2006;87(Pt 8):2135-43.
2005: Xinhai Wang; Irina Kochetkova; Asmahan Haddad; Teri Hoyt; David Hone; David W Pascual
Transgene vaccination using Ulex europaeus agglutinin I (UEA-1) for targeted mucosal immunization against HIV-1 envelope.
Vaccine 2005;23(29):3836-42.
2005: Jerald C Sadoff; David Hone
The role of "go no-go" decisions in TB vaccine development.
Microbes and infection / Institut Pasteur 2005;7(5-6):899-904.
2005: Alexander V Karasev; Scott Foulke; Candice Wellens; Amy Rich; Kyu J Shon; Izabela Zwierzynski; David Hone; Hilary Koprowski; Marvin Reitz
Plant based HIV-1 vaccine candidate: Tat protein produced in spinach.
Vaccine 2005;23(15):1875-80.
2003: Xinhai Wang; David Hone; Asmahan Haddad; Mohamed Tarek Shata; David W Pascual
M cell DNA vaccination for CTL immunity to HIV.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4717-25.
2003: Timothy R Fouts; Anthony DeVico; David Y Onyabe; Mohamed Tarek Shata; Kenneth C Bagley; George K Lewis; David Hone
Progress toward the development of a bacterial vaccine vector that induces high-titer long-lived broadly neutralizing antibodies against HIV-1.
FEMS immunology and medical microbiology 2003;37(2-3):129-34.
2003: Kenneth C Bagley; Mohamed Tarek Shata; David Y Onyabe; Anthony DeVico; Timothy R Fouts; George K Lewis; David Hone
Immunogenicity of DNA vaccines that direct the coincident expression of the 120 kDa glycoprotein of human immunodeficiency virus and the catalytic domain of cholera toxin.
Vaccine 2003;21(23):3335-41.
2003: Shibani Pati; James S Foulke; Oxana Barabitskaya; Jynho Kim; B C Nair; David Hone; Jennifer Smart; Ricardo A Feldman; Marvin Reitz
Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat.
Journal of virology 2003;77(10):5759-73.
2002: Simon M Agwale; Mohamed Tarek Shata; Marvin Reitz; V S Kalyanaraman; Robert C Gallo; M Popovic; David Hone
A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10037-41.
2002: Simon M Agwale; Clement Zeh; Kenneth E Robbins; Lillian Odama; Ae Youngpairoj; A Edubio; MO Njoku; N Sani-Gwarzo; M S Gboun; F Gao; Marvin Reitz; David Hone; Danuta Pieniazek; Charles Wambebe; Marcia L Kalish
Molecular surveillance of HIV-1 field strains in Nigeria in preparation for vaccine trials.
Vaccine 2002;20(16):2131-9.
2002: Anthony DeVico; Timothy R Fouts; Mohamed Tarek Shata; Roberta Kamin-Lewis; George K Lewis; David Hone
Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1.
Vaccine 2002;20(15):1968-74.
2002: David Hone; Anthony DeVico; Timothy R Fouts; David Y Onyabe; Simon M Agwale; Charles Wambebe; William A Blattner; Robert C Gallo; George K Lewis
Development of vaccination strategies that elicit broadly neutralizing antibodies against human immunodeficiency virus type 1 in both the mucosal and systemic immune compartments.
Journal of human virology 2002;5(1):17-23.
2001: Mohamed Tarek Shata; Marvin Reitz; Anthony DeVico; George K Lewis; David Hone
Mucosal and systemic HIV-1 Env-specific CD8(+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector.
Vaccine 2001;20(3-4):623-9.
2001: Mohamed Tarek Shata; David Hone
Vaccination with a Shigella DNA vaccine vector induces antigen-specific CD8(+) T cells and antiviral protective immunity.
Journal of virology 2001;75(20):9665-70.
2001: Simon M Agwale; Kenneth E Robbins; Lillian Odama; Ae Youngpairoj; Clement Zeh; A Edubio; O M Njoku; N Sani-Gwarzo; M F Gboun; F Gao; Marvin Reitz; David Hone; Thomas M Folks; Danuta Pieniazek; Charles Wambebe; Marcia L Kalish
Development of an env gp41-based heteroduplex mobility assay for rapid human immunodeficiency virus type 1 subtyping.
Journal of clinical microbiology 2001;39(6):2110-4.
2000: Timothy R Fouts; Robert G Tuskan; Karla Godfrey; Marvin Reitz; David Hone; George K Lewis; Anthony DeVico
Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex.
Journal of virology 2000;74(24):11427-36.
2000: Mohamed Tarek Shata; Liljana Stevceva; Simon M Agwale; George K Lewis; David Hone
Recent advances with recombinant bacterial vaccine vectors.
Molecular medicine today 2000;6(2):66-71.
1999: David W Pascual; David Hone; S Hall; Frederik W van Ginkel; M Yamamoto; Nancy Walters; Kohtaro Fujihashi; R J Powell; Shaoguang Wu; John L VanCott; Hiroshi Kiyono; Jerry R McGhee
Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response.
Infection and immunity 1999;67(12):6249-56.
1998: John L VanCott; S N Chatfield; M Roberts; David Hone; E L Hohmann; David W Pascual; M Yamamoto; Hiroshi Kiyono; Jerry R McGhee
Regulation of host immune responses by modification of Salmonella virulence genes.
Nature medicine 1998;4(11):1247-52.
1998: M A Ascón; David Hone; Nancy Walters; David W Pascual
Oral immunization with a Salmonella typhimurium vaccine vector expressing recombinant enterotoxigenic Escherichia coli K99 fimbriae elicits elevated antibody titers for protective immunity.
Infection and immunity 1998;66(11):5470-6.
1998: David Hone; J Powell; R W Crowley; D Maneval; George K Lewis
Lipopolysaccharide from an Escherichia coli htrB msbB mutant induces high levels of MIP-1 alpha and MIP-1 beta secretion without inducing TNF-alpha and IL-1 beta.
Journal of human virology 1998;1(4):251-6.
1998: DL Weinstein; B L O'Neill; David Hone; ES Metcalf
Differential early interactions between Salmonella enterica serovar Typhi and two other pathogenic Salmonella serovars with intestinal epithelial cells.
Infection and immunity 1998;66(5):2310-8.
1997: Shaoguang Wu; David W Pascual; George K Lewis; David Hone
Induction of mucosal and systemic responses against human immunodeficiency virus type 1 glycoprotein 120 in mice after oral immunization with a single dose of a Salmonella-HIV vector.
AIDS research and human retroviruses 1997;13(14):1187-94.
1997: Jan L Powell; Anita C Wright; Steven Wasserman; David Hone; J Glenn Morris
Release of tumor necrosis factor alpha in response to Vibrio vulnificus capsular polysaccharide in in vivo and in vitro models.
Infection and immunity 1997;65(9):3713-8.
1997: David W Pascual; R J Powell; George K Lewis; David Hone
Oral bacterial vaccine vectors for the delivery of subunit and nucleic acid vaccines to the organized lymphoid tissue of the intestine.
Behring Institute Mitteilungen 1997;(98):143-52.
1996: David Hone; Shaoguang Wu; R J Powell; David W Pascual; J Van Cott; Jerry R McGhee; T R Fouts; R G Tuskan; George K Lewis
Optimization of live oral Salmonella-HIV-1 vaccine vectors for the induction of HIV-specific mucosal and systemic immune responses.
Journal of biotechnology 1996;44(1-3):203-7.
1995: T R Fouts; R G Tuskan; S Chada; David Hone; George K Lewis
Construction and immunogenicity of Salmonella typhimurium vaccine vectors that express HIV-1 gp120.
Vaccine 1995;13(17):1697-705.
1995: Shaoguang Wu; David W Pascual; John L VanCott; Jerry R McGhee; D R Maneval; Myron M Levine; David Hone
Immune responses to novel Escherichia coli and Salmonella typhimurium vectors that express colonization factor antigen I (CFA/I) of enterotoxigenic E. coli in the absence of the CFA/I positive regulator cfaR.
Infection and immunity 1995;63(12):4933-8.
1995: Jorge A. Giron; J G Xu; C R González; David Hone; James B Kaper; Myron M Levine
Simultaneous expression of CFA/I and CS3 colonization factor antigens of enterotoxigenic Escherichia coli by delta aroC, delta aroD Salmonella typhi vaccine strain CVD 908.
Vaccine 1995;13(10):939-46.
1995: T R Fouts; George K Lewis; David Hone
Construction and characterization of a Salmonella typhi-based human immunodeficiency virus type 1 vector vaccine.
Vaccine 1995;13(6):561-9.
1994: Marcelo B Sztein; Steven Wasserman; Carol O Tacket; Robert Edelman; David Hone; A A Lindberg; Myron M Levine
Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi.
The Journal of infectious diseases 1994;170(6):1508-17.
1994: FR Noriega; J Y Wang; Genevieve A Losonsky; D R Maneval; David Hone; Myron M Levine
Construction and characterization of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine.
Infection and immunity 1994;62(11):5168-72.
1994: Derek Pickard; J Li; Mark Roberts; Duncan J Maskell; David Hone; Myron M Levine; Gordon Dougan; Steven N Chatfield
Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression.
Infection and immunity 1994;62(9):3984-93.
1994: David Hone; A M Harris; Myron M Levine
Adaptive acid tolerance response by Salmonella typhi and candidate live oral typhoid vaccine strains.
Vaccine 1994;12(10):895-8.
1994: David Hone; A M Harris; V Lim; Myron M Levine
Construction and characterization of isogenic O-antigen variants of Salmonella typhi.
Molecular microbiology 1994;13(3):525-30.
1994: C Gonzalez; David Hone; FR Noriega; Carol O Tacket; J R Davis; Genevieve A Losonsky; James P Nataro; S Hoffman; A Malik; Elizabeth H Nardin; Marcelo B Sztein; D G Heppner; T R Fouts; A Isibasi; Myron M Levine
Salmonella typhi vaccine strain CVD 908 expressing the circumsporozoite protein of Plasmodium falciparum: strain construction and safety and immunogenicity in humans.
The Journal of infectious diseases 1994;169(4):927-31.
1994: David Hone; George K Lewis; M Beier; A Harris; T McDaniels; T R Fouts
Expression of human immunodeficiency virus antigens in an attenuated Salmonella typhi vector vaccine.
Developments in biological standardization 1994;82():159-62.
1992: David Hone; Carol O Tacket; A M Harris; B Kay; Genevieve A Losonsky; Myron M Levine
Evaluation in volunteers of a candidate live oral attenuated Salmonella typhi vector vaccine.
The Journal of clinical investigation 1992;90(2):412-20.
1992: Augusto A. Franco-Mora; C Gonzalez; Orin S Levine; R Lagos; R H Hall; Stephen L Hoffman; M A Moechtar; E Gotuzzo; Myron M Levine; David Hone
Further consideration of the clonal nature of Salmonella typhi: evaluation of molecular and clinical characteristics of strains from Indonesia and Peru.
Journal of clinical microbiology 1992;30(8):2187-90.
1992: Carol O Tacket; David Hone; Roy Curtis; S M Kelly; Genevieve A Losonsky; L Guers; A M Harris; Robert Edelman; Myron M Levine
Comparison of the safety and immunogenicity of delta aroC delta aroD and delta cya delta crp Salmonella typhi strains in adult volunteers.
Infection and immunity 1992;60(2):536-41.
1992: Carol O Tacket; David Hone; Genevieve A Losonsky; L Guers; Robert Edelman; Myron M Levine
Clinical acceptability and immunogenicity of CVD 908 Salmonella typhi vaccine strain.
Vaccine 1992;10(7):443-6.
1992: Steven N Chatfield; Neil Fairweather; Ian G Charles; Derek Pickard; Myron M Levine; David Hone; M Posada; R A Strugnell; Gordon Dougan
Construction of a genetically defined Salmonella typhi Ty2 aroA, aroC mutant for the engineering of a candidate oral typhoid-tetanus vaccine.
Vaccine 1992;10(1):53-60.
1991: David Hone; A M Harris; Steven N Chatfield; Gordon Dougan; Myron M Levine
Construction of genetically defined double aro mutants of Salmonella typhi.
Vaccine 1991;9(11):810-6.
1991: S Servos; Steven N Chatfield; David Hone; Myron M Levine; G Dimitriadis; Derek Pickard; Gordon Dougan; Neil Fairweather; Ian G Charles
Molecular cloning and characterization of the aroD gene encoding 3-dehydroquinase from Salmonella typhi.
Journal of general microbiology 1991;137(1):147-52.
1990: A Aggarwal; S Kumar; R Jaffe; David Hone; M Gross; J Sadoff
Oral Salmonella: malaria circumsporozoite recombinants induce specific CD8+ cytotoxic T cells.
The Journal of experimental medicine 1990;172(4):1083-90.
1990: Myron M Levine; David Hone; Carol O Tacket; C Ferreccio; Stanley J Cryz
Clinical and field trials with attenuated Salmonella typhi as live oral vaccines and as "carrier" vaccines.
Research in microbiology 1990;141(7-8):807-16.
1989: David Hone; J Hackett
Vaccination against enteric bacterial diseases.
Reviews of infectious diseases 1989;11(6):853-77.
1988: David Hone; Stephen R Attridge; L van den Bosch; J Hackett
A chromosomal integration system for stabilization of heterologous genes in Salmonella based vaccine strains.
Microbial pathogenesis 1988;5(6):407-18.
1988: David Hone; Stephen R Attridge; B Forrest; Renato Morona; D Daniels; J T LaBrooy; R C Bartholomeusz; D J Shearman; J Hackett
A galE via (Vi antigen-negative) mutant of Salmonella typhi Ty2 retains virulence in humans.
Infection and immunity 1988;56(5):1326-33.
1987: David Hone; Renato Morona; Stephen R Attridge; J Hackett
Construction of defined galE mutants of Salmonella for use as vaccines.
The Journal of infectious diseases 1987;156(1):167-74.