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Philip van der Merwe

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Chemicals & Drugs

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Lymphocyte Activation

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TOP 3
Himadri Mukhopadhyay; Philip van der Merwe; Shaun-Paul Cordoba; Philip K Maini; Omer Dushek
Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.
Jun F Allard; Daniel Coombs; Omer Dushek; Philip van der Merwe
Mechanical modulation of receptor-ligand interactions at cell-cell interfaces.
Joseph J Illingworth; Philip van der Merwe
Dissecting T-cell activation with high-resolution live-cell microscopy.

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All Publications

2013: Himadri Mukhopadhyay; Philip van der Merwe; Shaun-Paul Cordoba; Philip K Maini; Omer Dushek
Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.
PLoS computational biology 2013;9(3):e1003004.
2012: Jun F Allard; Daniel Coombs; Omer Dushek; Philip van der Merwe
Mechanical modulation of receptor-ligand interactions at cell-cell interfaces.
Biophysical journal 2012;102(6):1265-73.
2012: Joseph J Illingworth; Philip van der Merwe
Dissecting T-cell activation with high-resolution live-cell microscopy.
Immunology 2012;135(3):198-206.
2012: Philippe Robert; Milos Aleksic; Pierre Bongrand; Vincenzo Cerundolo; Omer Dushek; Philip van der Merwe
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands.
Biophysical journal 2012;102(2):248-57.
2012: Philip van der Merwe; Hao Zhang; Shaun-Paul Cordoba
Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?
Frontiers in immunology 2012;3():29.
2011: Hao Zhang; Shaun-Paul Cordoba; Omer Dushek; Philip van der Merwe
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):19323-8.
2011: Nigel J Burroughs; Michael L Dustin; Karsten Köhler; Vladimir Miloserdov; Philip van der Merwe; Daniel M Davis
Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses.
PLoS computational biology 2011;7(8):e1002076.
2011: Omer Dushek; Philip van der Merwe; Vahid Shahrezaei
Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins.
Biophysical journal 2011;100(5):1189-97.
2011: Philip van der Merwe; Shaun-Paul Cordoba
Late arrival: recruiting coreceptors to the T cell receptor complex.
Immunity 2011;34(1):1-3.
2011: Omer Dushek; Yan-Chun Peng; Richard J Wheeler; Hao Zhang; Milos Aleksic; Vincenzo Cerundolo; Ji-Li Chen; Daniel Coombs; Shaun-Paul Cordoba; Tao Dong; Philip van der Merwe
Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.
Science signaling 2011;4(176):ra39.
2011: Simon J Davis; Philip van der Merwe
Lck and the nature of the T cell receptor trigger.
Trends in immunology 2011;32(1):1-5.
2011: Philip van der Merwe; Omer Dushek
Mechanisms for T cell receptor triggering.
Nature reviews. Immunology 2011;11(1):47-55.
2010: Ricardo A Fernandes; Chao Yu; Alexandre M Carmo; Edward J Evans; Philip van der Merwe; Simon J Davis
What controls T cell receptor phosphorylation?
Cell 2010;142(5):668-9.
2010: Joanna Brzostek; Jian-Guo Chai; Friedemann Gebhardt; Dirk H Busch; Rui Zhao; Philip van der Merwe; Keith G Gould
Ligand dimensions are important in controlling NK-cell responses.
European journal of immunology 2010;40(7):2050-9.
2010: Milos Aleksic; Omer Dushek; Hao Zhang; Eugene Shenderov; Ji-Li Chen; Vincenzo Cerundolo; Daniel Coombs; Philip van der Merwe
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.
Immunity 2010;32(2):163-74.
2010: Ji-Li Chen; Anthony J Morgan; Guillaume Stewart-Jones; Dawn Shepherd; Giovanna Bossi; Linda Wooldridge; Sarah L Hutchinson; Andrew K Sewell; Gillian M Griffiths; Philip van der Merwe; E Yvonne Jones; Antony Galione; Vincenzo Cerundolo
Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1829-39.
2010: Karsten Köhler; Shiqiu Xiong; Joanna Brzostek; Maryam Mehrabi; Philipp Eissmann; Alice Harrison; Shaun-Paul Cordoba; Stephane Oddos; Vladimir Miloserdov; Keith Gould; Nigel J Burroughs; Philip van der Merwe; Daniel M Davis
Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.
PloS one 2010;5(11):e15374.
2010: Philip van der Merwe; Paul D Dunne; David Klenerman; Simon J Davis
Taking T cells beyond the diffraction limit.
Nature immunology 2010;11(1):51-2.
2009: Kaushik Choudhuri; Mathew Parker; Anita Milicic; david cole; Michael K Shaw; Andrew K Sewell; Guillaume Stewart-Jones; Tao Dong; Keith G Gould; Philip van der Merwe
Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation.
The Journal of biological chemistry 2009;284(38):26096-105.
2009: Michael J Palmowski; Mathew Parker; Kaushik Choudhuri; Christopher Chiu; Margaret F C Callan; Philip van der Merwe; Vincenzo Cerundolo; Keith G Gould
A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8+ T cell responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4565-71.
2009: Maria Harkiolaki; Samantha L Holmes; Pia Svendsen; Jon W Gregersen; Lise T Jensen; Roisin McMahon; Manuel A Friese; Gijs van Boxel; Ruth Etzensperger; John S Tzartos; Kamil Kranc; Sarah Sainsbury; Karl Harlos; Elizabeth D Mellins; Jackie Palace; Margaret M Esiri; Philip van der Merwe; E Yvonne Jones; Lars Fugger
T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.
Immunity 2009;30(3):348-57.
2008: Oren Milstein; Su-Yi Tseng; Toby Starr; Jaime Llodra; Andrea Nans; Mengling Liu; Martin K Wild; Philip van der Merwe; David L Stokes; Yair Reisner; Michael L Dustin
Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse.
The Journal of biological chemistry 2008;283(49):34414-22.
2008: Jemima Cordle; Christina Redfieldz; Martin Stacey; Philip van der Merwe; Antony C Willis; Brian R Champion; Sophie Hambleton; Penny A Handford
Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity.
The Journal of biological chemistry 2008;283(17):11785-93.
2008: Lisa M Jones; Wei Yang; Anna W Maniccia; Alice Harrison; Philip van der Merwe; Jenny J Yang
Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity.
Protein science : a publication of the Protein Society 2008;17(3):439-49.
2008: Galit Denkberg; Victoria S Stronge; Efrat Zahavi; Paola Pittoni; Ravit Oren; Dawn Shepherd; Mariolina Salio; Corinna McCarthy; Petr A Illarionov; Philip van der Merwe; Gurdyal S Besra; Paolo Dellabona; Giulia Casorati; Vincenzo Cerundolo; Yoram Reiter
Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.
European journal of immunology 2008;38(3):829-40.
2008: Jeffrey Ishizuka; Guillaume Stewart-Jones; Philip van der Merwe; John I Bell; Andrew J McMichael; E Yvonne Jones
The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.
Immunity 2008;28(2):171-82.
2007: A Radu Aricescu; Christian Siebold; Kaushik Choudhuri; Veronica T Chang; Weixian Lu; Simon J Davis; Philip van der Merwe; E Yvonne Jones
Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism.
Science (New York, N.Y.) 2007;317(5842):1217-20.
2007: Kaushik Choudhuri; Philip van der Merwe
Molecular mechanisms involved in T cell receptor triggering.
Seminars in immunology 2007;19(4):255-61.
2007: Corinna McCarthy; Dawn Shepherd; Sebastian Fleire; Victoria S Stronge; Michael Koch; Petr A Illarionov; Giovanna Bossi; Mariolina Salio; Galit Denkberg; Faye Reddington; Andrea Tarlton; Gopal R Bommineni; Richard R Schmidt; Yoram Reiter; Gillian M Griffiths; Philip van der Merwe; Gurdyal S Besra; E Yvonne Jones; Facundo D Batista; Vincenzo Cerundolo
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
The Journal of experimental medicine 2007;204(5):1131-44.
2007: Alice Kearney; Adam Avramovic; Mónica A A Castro; Alexandre M Carmo; Simon J Davis; Philip van der Merwe
The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction.
The Journal of biological chemistry 2007;282(18):13160-6.
2007: Catherine Mazza; Nathalie Auphan-Anezin; Claude Gregoire; Annick Guimezanes; Christine Kellenberger; Alain Roussel; Alice Kearney; Philip van der Merwe; Anne-Marie Schmitt-Verhulst; Bernard Malissen
How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
The EMBO journal 2007;26(7):1972-83.
2007: Nigel J Burroughs; Philip van der Merwe
Stochasticity and spatial heterogeneity in T-cell activation.
Immunological reviews 2007;216():69-80.
2007: Jelena Jovanovic; Junichi Takagi; Laurence Choulier; Nicola G A Abrescia; David I Stuart; Philip van der Merwe; Helen J Mardon; Penny A Handford
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.
The Journal of biological chemistry 2007;282(9):6743-51.
2007: Marco V Bayas; Alice Kearney; Adam Avramovic; Philip van der Merwe; Deborah E Leckband
Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58.
The Journal of biological chemistry 2007;282(8):5589-96.
2006: Edward J Evans; Mónica A A Castro; Ronan O'Brien; Alice Kearney; Heather Walsh; Lisa M Sparks; Michael G Tucknott; Elizabeth A Davies; Alexandre M Carmo; Philip van der Merwe; David I Stuart; E Yvonne Jones; John E Ladbury; Shinji Ikemizu; Simon J Davis
Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.
The Journal of biological chemistry 2006;281(39):29309-20.
2006: Nigel J Burroughs; Zorana Lazic; Philip van der Merwe
Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.
Biophysical journal 2006;91(5):1619-29.
2006: Simon J Davis; Philip van der Merwe
The kinetic-segregation model: TCR triggering and beyond.
Nature immunology 2006;7(8):803-9.
2006: A Radu Aricescu; Wai-Ching Hon; Christian Siebold; Weixian Lu; Philip van der Merwe; E Yvonne Jones
Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.
The EMBO journal 2006;25(4):701-12.
2006: Astrid K N Iversen; Guillaume Stewart-Jones; Gerald Learn; Natasha Christie; Christina Sylvester-Hviid; Andrew E Armitage; Rupert Kaul; Tara Beattie; Jean K Lee; Yanping Li; Pojchong Chotiyarnwong; Tao Dong; Xiaoning Xu; Mark A Luscher; Kelly MacDonald; Henrik Ullum; Bente Klarlund Pedersen; Peter Skinhøj; Lars Fugger; Soren Buus; James I Mullins; E Yvonne Jones; Philip van der Merwe; Andrew J McMichael
Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.
Nature immunology 2006;7(2):179-89.
2006: Mitsunori Shiroishi; Kimiko Kuroki; Kouhei Tsumoto; Akiko Yokota; Takashi Sasaki; Kimie Amano; Tsukasa Shimojima; Yasuo Shirakihara; Linda Rasubala; Philip van der Merwe; Izumi Kumagai; Daisuke Kohda; Katsumi Maenaka
Entropically driven MHC class I recognition by human inhibitory receptor leukocyte Ig-like receptor B1 (LILRB1/ILT2/CD85j).
Journal of molecular biology 2006;355(2):237-48.
2005: Kaushik Choudhuri; David Wiseman; Marion H Brown; Keith Gould; Philip van der Merwe
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
Nature 2005;436(7050):578-82.
2005: Kaushik Choudhuri; Alice Kearney; Talitha Bakker; Philip van der Merwe
Immunology: how do T cells recognize antigen?
Current biology : CB 2005;15(10):R382-5.
2005: Ji-Li Chen; Guillaume Stewart-Jones; Giovanna Bossi; Nikolai M Lissin; Linda Wooldridge; Ed Man-Lik Choi; Gerhard Held; P Rod Dunbar; Robert M Esnouf; malkit sami; Jonathan M Boulter; Pierre J Rizkallah; Christoph Renner; Andrew Sewell; Philip van der Merwe; Bent K Jakobsen; Gillian Griffiths; E Yvonne Jones; Vincenzo Cerundolo
Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
The Journal of experimental medicine 2005;201(8):1243-55.
2005: Wei Yang; Anna L Wilkins; Yiming Ye; Zhi-Ren Liu; Shun-yi Li; Jeffrey L Urbauer; Homme W Hellinga; Alice Kearney; Philip van der Merwe; Jenny J Yang
Design of a calcium-binding protein with desired structure in a cell adhesion molecule.
Journal of the American Chemical Society 2005;127(7):2085-93.
2004: Tao Dong; Guillaume Stewart-Jones; Nan Chen; Philippa Easterbrook; Xiaoning Xu; Laura Papagno; Victor Appay; Michael Weekes; Christopher Conlon; Celsa A Spina; Susan Little; Gavin Screaton; Philip van der Merwe; Douglas D Richman; Andrew J McMichael; E Yvonne Jones; Sarah L Rowland-Jones
HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor.
The Journal of experimental medicine 2004;200(12):1547-57.
2004: Jean K Lee; Guillaume Stewart-Jones; Tao Dong; Karl Harlos; katalin di gleria; Lucy Dorrell; Daniel C Douek; Philip van der Merwe; E Yvonne Jones; Andrew J McMichael
T cell cross-reactivity and conformational changes during TCR engagement.
The Journal of experimental medicine 2004;200(11):1455-66.
2003: Simon J Davis; Philip van der Merwe
TCR triggering: co-receptor-dependent or -independent?
Trends in immunology 2003;24(12):624-6; author reply 626-7.
2003: Mitsunori Shiroishi; Kouhei Tsumoto; Kimie Amano; Yasuo Shirakihara; Marco COLONna; Veronique M Braud; David S J Allan; Azure Makadzange; Sarah Rowland-Jones; Benjamin E Willcox; E Yvonne Jones; Philip van der Merwe; Izumi Kumagai; Katsumi Maenaka
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8856-61.
2003: Simon J Davis; Shinji Ikemizu; Edward J Evans; Lars Fugger; Talitha Bakker; Philip van der Merwe
The nature of molecular recognition by T cells.
Nature immunology 2003;4(3):217-24.
2003: Jean-Baptiste Reiser; Claudine Darnault; Claude Grégoire; Thomas Mosser; Gilbert Mazza; Alice Kearney; Philip van der Merwe; Juan C Fontecilla-Camps; Dominique Housset; Bernard Malissen
CDR3 loop flexibility contributes to the degeneracy of TCR recognition.
Nature immunology 2003;4(3):241-7.
2003: Claudine Irles; Antony Symons; Frédérique Michel; Talitha Bakker; Philip van der Merwe; Oreste Acuto
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.
Nature immunology 2003;4(2):189-97.
2003: Philip van der Merwe; Simon J Davis
Molecular interactions mediating T cell antigen recognition.
Annual review of immunology 2003;21():659-84.
2002: Philip van der Merwe
Do T cell receptors do it alone?
Nature immunology 2002;3(12):1122-3.
2002: Boru Zhu; Elizabeth A Davies; Philip van der Merwe; Tammy Calvert; Deborah E Leckband
Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48.
Biochemistry 2002;41(40):12163-70.
2002: Alison V Collins; Douglas W Brodie; Robert J C Gilbert; Andrea Iaboni; Raquel Manso-Sancho; Björn Walse; David I Stuart; Philip van der Merwe; Simon J Davis
The interaction properties of costimulatory molecules revisited.
Immunity 2002;17(2):201-10.
2002: Philip van der Merwe
Formation and function of the immunological synapse.
Current opinion in immunology 2002;14(3):293-8.
2002: Philip van der Merwe; Simon J Davis
Immunology. The immunological synapse--a multitasking system.
Science (New York, N.Y.) 2002;295(5559):1479-80.
2002: Talitha Bakker; Philip van der Merwe
Self-help in T cell recognition?
Nature immunology 2002;3(1):11-2.
2001: Katsumi Maenaka; Philip van der Merwe; D I Stuart; E Y Jones; P Sondermann
The human low affinity Fcgamma receptors IIa, IIb, and III bind IgG with fast kinetics and distinct thermodynamic properties.
The Journal of biological chemistry 2001;276(48):44898-904.
2001: A Arcaro; Claude Grégoire; Talitha Bakker; Lucia Baldi; M Jordan; L Goffin; Nicole Boucheron; Florian M Wurm; Philip van der Merwe; Bernard Malissen; Immanuel F Luescher
CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes.
The Journal of experimental medicine 2001;194(10):1485-95.
2001: Martin K Wild; Min-Chuan Huang; U Schulze-Horsel; Philip van der Merwe; Dietmar Vestweber
Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1.
The Journal of biological chemistry 2001;276(34):31602-12.
2001: Philip van der Merwe
The TCR triggering puzzle.
Immunity 2001;14(6):665-8.
2001: Sabine M W Van Rossenberg; Leo A J M Sliedregt; R Autar; C Piperi; Philip van der Merwe; Theo Van berkel; Johan Kuiper; Erik A L Biessen
A structure-function study of ligand recognition by CD22beta.
The Journal of biological chemistry 2001;276(16):12967-73.
2001: S J Davis; Philip van der Merwe
The immunological synapse: required for T cell receptor signalling or directing T cell effector function?
Current biology : CB 2001;11(8):R289-91.
2001: Leo A J M Sliedregt; Sabine M W Van Rossenberg; R Autar; Rob Valentijn; Gijsbert A van der Marel; Jacques H van Boom; C Piperi; Philip van der Merwe; Johan Kuiper; Theo Van berkel; Erik A L Biessen
Design and synthesis of a multivalent homing device for targeting to murine CD22.
Bioorganic & medicinal chemistry 2001;9(1):85-97.
2001: M Kemeny; J Gordon; A Hayday; N Hogg; F Y Liew; Mark Peakman; Philip van der Merwe
Immunology in the new millennium: building on tradition.
Immunology 2001;102(1):1.
2000: E J Lepin; Judy Bastin; David S J Allan; Giovanna Roncador; Veronique M Braud; D Y Mason; Philip van der Merwe; Andrew J McMichael; John I Bell; S H Powis; Christopher A O'Callaghan
Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.
European journal of immunology 2000;30(12):3552-61.
2000: Philip van der Merwe
Modeling costimulation.
Nature immunology 2000;1(3):194-5.
2000: George F Gao; Benjamin E Willcox; Jessica R Wyer; Jonathan M Boulter; Christopher A O'Callaghan; Katsumi Maenaka; David I Stuart; E Yvonne Jones; Philip van der Merwe; John I Bell; Bent K Jakobsen
Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.
The Journal of biological chemistry 2000;275(20):15232-8.
2000: D Brodie; Alison V Collins; Andrea Iaboni; Janet A Fennelly; Lisa M Sparks; X N Xu; Philip van der Merwe; Simon J Davis
LICOS, a primordial costimulatory ligand?
Current biology : CB 2000;10(6):333-6.
2000: Philip van der Merwe; S J Davis; A S Shaw; M L Dustin
Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition.
Seminars in immunology 2000;12(1):5-21.
1999: Philip van der Merwe
A subtle role for CD2 in T cell antigen recognition.
The Journal of experimental medicine 1999;190(10):1371-4.
1999: Benjamin E Willcox; George F Gao; Jessica R Wyer; Christopher A O'Callaghan; Jonathan M Boulter; E Yvonne Jones; Philip van der Merwe; John I Bell; Bent K Jakobsen
Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.
Protein science : a publication of the Protein Society 1999;8(11):2418-23.
1999: Katsumi Maenaka; T Juji; T Nakayama; Jessica R Wyer; George F Gao; Taeko Maenaka; Nathan R Zaccai; A Kikuchi; T Yabe; K Tokunaga; K Tadokoro; David I Stuart; E Yvonne Jones; Philip van der Merwe
Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties.
The Journal of biological chemistry 1999;274(40):28329-34.
1999: Ravi Malaviya; Z Gao; K Thankavel; Philip van der Merwe; Soman N Abraham
The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8110-5.
1999: M K Wild; A Cambiaggi; Marion H Brown; Elizabeth A Davies; H Ohno; Takashi Saito; Philip van der Merwe
Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex.
The Journal of experimental medicine 1999;190(1):31-41.
1999: Philip van der Merwe
Leukocyte adhesion: High-speed cells with ABS.
Current biology : CB 1999;9(11):R419-22.
1999: Shinji Ikemizu; Lisa M Sparks; Philip van der Merwe; Karl Harlos; David I Stuart; E Yvonne Jones; Simon J Davis
Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4289-94.
1999: Benjamin E Willcox; George F Gao; Jessica R Wyer; J E Ladbury; John I Bell; Bent K Jakobsen; Philip van der Merwe
TCR binding to peptide-MHC stabilizes a flexible recognition interface.
Immunity 1999;10(3):357-65.
1999: Jessica R Wyer; Benjamin E Willcox; George F Gao; UC Gerth; Simon J Davis; John I Bell; Philip van der Merwe; Bent K Jakobsen
T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.
Immunity 1999;10(2):219-25.
1998: Marion H Brown; Kent S Boles; Philip van der Merwe; Vinay Kumar; P A Mathew; A N Barclay
2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.
The Journal of experimental medicine 1998;188(11):2083-90.
1998: Susan M Lea; R M Powell; Thomas A McKee; David J Evans; D Brown; David I Stuart; Philip van der Merwe
Determination of the affinity and kinetic constants for the interaction between the human virus echovirus 11 and its cellular receptor, CD55.
The Journal of biological chemistry 1998;273(46):30443-7.
1998: Michael L Dustin; M W Olszowy; Amy D Holdorf; J Li; Shannon K Bromley; N Desai; P Widder; F Rosenberger; Philip van der Merwe; Paul M Allen; Andrey S Shaw
A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
Cell 1998;94(5):667-77.
1998: Simon J Davis; Shinji Ikemizu; M K Wild; Philip van der Merwe
CD2 and the nature of protein interactions mediating cell-cell recognition.
Immunological reviews 1998;163():217-36.
1998: Simon J Davis; Elizabeth A Davies; M G Tucknott; E Yvonne Jones; Philip van der Merwe
The role of charged residues mediating low affinity protein-protein recognition at the cell surface by CD2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(10):5490-4.
1998: P R Crocker; E A Clark; Marie T Filbin; S Gordon; Y Jones; John Kehrl; S Kelm; N Le Douarin; L Powell; J Roder; Ronald Schnaar; D C Sgroi; K Stamenkovic; R Schauer; M Schachner; T K van den Berg; Philip van der Merwe; S M Watt; A Varki
Siglecs: a family of sialic-acid binding lectins.
Glycobiology 1998;8(2):v.
1998: M W Nicholson; A Neil Barclay; M S Singer; S D Rosen; Philip van der Merwe
Affinity and kinetic analysis of L-selectin (CD62L) binding to glycosylation-dependent cell-adhesion molecule-1.
The Journal of biological chemistry 1998;273(2):763-70.
1997: Michael L Dustin; David E Golan; De-Min Zhu; J M Miller; W Meier; Elizabeth A Davies; Philip van der Merwe
Low affinity interaction of human or rat T cell adhesion molecule CD2 with its ligand aligns adhering membranes to achieve high physiological affinity.
The Journal of biological chemistry 1997;272(49):30889-98.
1997: DM Baorto; Z Gao; Ravi Malaviya; M L Dustin; Philip van der Merwe; Douglas M Lublin; Soman N Abraham
Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic.
Nature 1997;389(6651):636-9.
1997: Anne Pierres; Anne-Marie Benoliel; Pierre Bongrand; Philip van der Merwe
The dependence of the association rate of surface-attached adhesion molecules CD2 and CD48 on separation distance.
FEBS letters 1997;403(3):239-44.
1997: Philip van der Merwe; D L Bodian; S Daenke; P Linsley; Simon J Davis
CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics.
The Journal of experimental medicine 1997;185(3):393-403.
1996: Anne Pierres; Anne-Marie Benoliel; Pierre Bongrand; Philip van der Merwe
Determination of the lifetime and force dependence of interactions of single bonds between surface-attached CD2 and CD48 adhesion molecules.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15114-8.
1996: E Melton; N Sarner; M Torkar; Philip van der Merwe; Jennifer Q Russell; Ralph C Budd; Clio Mamalaki; Mauro Tolaini; Dimitris Kioussis; Rose Zamoyska
Transgene-encoded human CD2 acts in a dominant negative fashion to modify thymocyte selection signals in mice.
European journal of immunology 1996;26(12):2952-63.
1996: S J Davis; Philip van der Merwe
CD2: an exception to the immunoglobulin superfamily concept?
Science (New York, N.Y.) 1996;273(5279):1241-2.
1996: Mark S B McAlister; H R Mott; Philip van der Merwe; Iain D Campbell; Simon J Davis; Paul C Driscoll
NMR analysis of interacting soluble forms of the cell-cell recognition molecules CD2 and CD48.
Biochemistry 1996;35(19):5982-91.
1996: Philip van der Merwe; Paul R Crocker; M Vinson; A Neil Barclay; R Schauer; Soerge Kelm
Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22.
The Journal of biological chemistry 1996;271(16):9273-80.
1996: M Vinson; Philip van der Merwe; Soerge Kelm; A May; E Yvonne Jones; Paul R Crocker
Characterization of the sialic acid-binding site in sialoadhesin by site-directed mutagenesis.
The Journal of biological chemistry 1996;271(16):9267-72.
1996: Simon J Davis; Philip van der Merwe
The structure and ligand interactions of CD2: implications for T-cell function.
Immunology today 1996;17(4):177-87.
1996: Philip van der Merwe; A N Barclay
Analysis of cell-adhesion molecule interactions using surface plasmon resonance.
Current opinion in immunology 1996;8(2):257-61.
1995: D Nath; Philip van der Merwe; Soerge Kelm; P Bradfield; Paul R Crocker
The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. Comparison with CD22.
The Journal of biological chemistry 1995;270(44):26184-91.
1995: Simon J Davis; Elizabeth A Davies; Philip van der Merwe
Mutational analysis of the epitopes recognized by anti-(rat CD2) and anti-(rat CD48) monoclonal antibodies.
Biochemical Society transactions 1995;23(1):188-94.
1995: Simon J Davis; Elizabeth A Davies; A Neil Barclay; S Daenke; D L Bodian; E Yvonne Jones; David I Stuart; Terry D Butters; Raymond A Dwek; Philip van der Merwe
Ligand binding by the immunoglobulin superfamily recognition molecule CD2 is glycosylation-independent.
The Journal of biological chemistry 1995;270(1):369-75.
1995: Philip van der Merwe; P N McNamee; Elizabeth A Davies; A Neil Barclay; Simon J Davis
Topology of the CD2-CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells.
Current biology : CB 1995;5(1):74-84.
1994: Philip van der Merwe; A N Barclay
Transient intercellular adhesion: the importance of weak protein-protein interactions.
Trends in biochemical sciences 1994;19(9):354-8.
1994: Philip van der Merwe; A Neil Barclay; D W Mason; Elizabeth A Davies; B Paul Morgan; Masahide Tone; A K Krishnam; C Ianelli; Simon J Davis
Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59.
Biochemistry 1994;33(33):10149-60.
1994: B Kieffer; Paul C Driscoll; Iain D Campbell; Antony C Willis; Philip van der Merwe; Simon J Davis
Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.
Biochemistry 1994;33(15):4471-82.
1993: Philip van der Merwe; Marion H Brown; Simon J Davis; A Neil Barclay
Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.
The EMBO journal 1993;12(13):4945-54.
1993: Simon J Davis; E Yvonne Jones; D L Bodian; A Neil Barclay; Philip van der Merwe
Analysis of the structure and interactions of CD2.
Biochemical Society transactions 1993;21(4):952-8.
1993: Philip van der Merwe; Marion H Brown; Simon J Davis; A Neil Barclay
Measuring very low affinity interactions between immunoglobulin superfamily cell-adhesion molecules.
Biochemical Society transactions 1993;21(4):340S.
1993: Philip van der Merwe; D C McPherson; Marion H Brown; A Neil Barclay; Jason G Cyster; A F Williams; Simon J Davis
The NH2-terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2.
European journal of immunology 1993;23(6):1373-7.
1992: James S Davidson; I K Wakefield; Philip van der Merwe; Robert P Millar
Involvement of pertussis toxin-sensitive and -insensitive GTP-binding proteins in luteinizing hormone exocytosis distal to second messenger generation.
Cellular signalling 1992;4(4):379-84.
1992: P V Kaye; Philip van der Merwe; Robert P Millar; James S Davidson
Arachidonic acid-induced LH release is ATP-independent and insensitive to N-ethyl maleimide.
The Journal of endocrinology 1992;132(1):77-82.
1991: Philip van der Merwe; Robert P Millar; I K Wakefield; James S Davidson
Inhibition of luteinizing-hormone exocytosis by guanosine 5'-[gamma-thio]triphosphate reveals involvement of a GTP-binding protein distal to second-messenger generation.
The Biochemical journal 1991;275 ( Pt 2)():399-405.
1991: J Davidson; Philip van der Merwe; I Wakefield; Robert P Millar
Mechanisms of luteinizing hormone secretion: new insights from studies with permeabilized cells.
Molecular and cellular endocrinology 1991;76(1-3):C33-8.
1990: M B Macrae; James S Davidson; Robert P Millar; Philip van der Merwe
Cyclic AMP stimulates luteinizing-hormone (lutropin) exocytosis in permeabilized sheep anterior-pituitary cells. Synergism with protein kinase C and calcium.
The Biochemical journal 1990;271(3):635-9.
1990: Philip van der Merwe; Robert P Millar; I K Wakefield; M B Macrae; James S Davidson
Staurosporine enhances gonadotrophin-releasing hormone-stimulated luteinizing hormone secretion.
FEBS letters 1990;267(1):111-3.
1990: Philip van der Merwe; Robert P Millar; James S Davidson
Calcium stimulates luteinizing-hormone (lutropin) exocytosis by a mechanism independent of protein kinase C.
The Biochemical journal 1990;268(2):493-8.
1990: James S Davidson; I K Wakefield; U Sohnius; Philip van der Merwe; Robert P Millar
A novel extracellular nucleotide receptor coupled to phosphoinositidase-C in pituitary cells.
Endocrinology 1990;126(1):80-7.
1989: Philip van der Merwe; Robert P Millar; I K Wakefield; James S Davidson
Mechanisms of luteinizing-hormone exocytosis in Staphylococcus aureus-alpha-toxin-permeabilized sheep gonadotropes.
The Biochemical journal 1989;264(3):901-8.
1989: Philip van der Merwe; I K Wakefield; J Fine; Robert P Millar; James S Davidson
Extracellular adenosine triphosphate activates phospholipase C and mobilizes intracellular calcium in primary cultures of sheep anterior pituitary cells.
FEBS letters 1989;243(2):333-6.
1988: Philip van der Merwe
Tumour necrosis factor.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1988;74(8):411-7.
1988: A Rosen; Philip van der Merwe; James S Davidson
Effects of SV40 transformation on intercellular gap junctional communication in human fibroblasts.
Cancer research 1988;48(12):3485-9.