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Steven Projan

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Staphylococcal Infections

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Karen Bush; Patrice Courvalin; Gautam Dantas; Julian Davies; Barry Eisenstein; Pentti Huovinen; George A Jacoby; Roy Kishony; Barry N Kreiswirth; Elizabeth Kutter; Stephen A Lerner; Stuart Levy; Kim Lewis; Olga Lomovskaya; Jeffrey H Miller; Shahriar Mobashery; Laura J V Piddock; Steven Projan; Christopher M Thomas; Alexander Tomasz; Paul Tulkens; Timothy R Walsh; James D Watson; Jan Witkowski; Wolfgang Witte; Gerry Wright; Pamela Yeh; Helen I Zgurskaya
Tackling antibiotic resistance.
Steven Projan
Francis Tally and the discovery and development of tigecycline: a personal reminiscence.
Peter J Petersen; C Hal Jones; Aranapakam M Venkatesan; Tarek S Mansour; Steven Projan; Patricia A Bradford
Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489.

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All Publications

2011: Karen Bush; Patrice Courvalin; Gautam Dantas; Julian Davies; Barry Eisenstein; Pentti Huovinen; George A Jacoby; Roy Kishony; Barry N Kreiswirth; Elizabeth Kutter; Stephen A Lerner; Stuart Levy; Kim Lewis; Olga Lomovskaya; Jeffrey H Miller; Shahriar Mobashery; Laura J V Piddock; Steven Projan; Christopher M Thomas; Alexander Tomasz; Paul Tulkens; Timothy R Walsh; James D Watson; Jan Witkowski; Wolfgang Witte; Gerry Wright; Pamela Yeh; Helen I Zgurskaya
Tackling antibiotic resistance.
Nature reviews. Microbiology 2011;9(12):894-6.
2010: Steven Projan
Francis Tally and the discovery and development of tigecycline: a personal reminiscence.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;50 Suppl 1():S24-5.
2009: Peter J Petersen; C Hal Jones; Aranapakam M Venkatesan; Tarek S Mansour; Steven Projan; Patricia A Bradford
Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489.
Antimicrobial agents and chemotherapy 2009;53(2):370-84.
2008: Andrew J Dorner; Steven Projan
New technologies for the engineering of novel protein therapeutics and the personalization of medicine.
Current opinion in pharmacology 2008;8(5):598-9.
2008: Steven Projan
Whither antibacterial drug discovery?
Drug discovery today 2008;13(7-8):279-80.
2007: Steven Projan; Patricia A Bradford
Late stage antibacterial drugs in the clinical pipeline.
Current opinion in microbiology 2007;10(5):441-6.
2007: Steven Projan
(Genome) size matters.
Antimicrobial agents and chemotherapy 2007;51(4):1133-4.
2007: Evan Loh; Peter J Petersen; Evelyn Ellis-Grosse; Phaik-Eng Sum; Steven Projan
Tigecycline: a case study.
Expert opinion on drug discovery 2007;2(3):403-18.
2006: James E Cassat; Paul Dunman; Ellen Murphy; Steven Projan; Karen E Beenken; Katherine J Palm; Soo-Jin Yang; Kelly C Rice; Kenneth W Bayles; Mark S Smeltzer
Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390.
Microbiology (Reading, England) 2006;152(Pt 10):3075-90.
2006: Kelsi L Anderson; Corbette Roberts; Terrence Disz; Veronika Vonstein; Kaitlyn Hwang; Ross Overbeek; Patrick D Olson; Steven Projan; Paul Dunman
Characterization of the Staphylococcus aureus heat shock, cold shock, stringent, and SOS responses and their effects on log-phase mRNA turnover.
Journal of bacteriology 2006;188(19):6739-56.
2006: Steven Projan; Mirjana Nesin; Paul Dunman
Staphylococcal vaccines and immunotherapy: to dream the impossible dream?
Current opinion in pharmacology 2006;6(5):473-9.
2006: Soo-Jin Yang; Paul Dunman; Steven Projan; Kenneth W Bayles
Characterization of the Staphylococcus aureus CidR regulon: elucidation of a novel role for acetoin metabolism in cell death and lysis.
Molecular microbiology 2006;60(2):458-68.
2006: Corbette Roberts; Kelsi L Anderson; Ellen Murphy; Steven Projan; William Mounts; Barry Hurlburt; Mark S Smeltzer; Ross Overbeek; Terrence Disz; Paul Dunman
Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives.
Journal of bacteriology 2006;188(7):2593-603.
2006: Thanh T Luong; Paul Dunman; Ellen Murphy; Steven Projan; Chia Y Lee
Transcription Profiling of the mgrA Regulon in Staphylococcus aureus.
Journal of bacteriology 2006;188(5):1899-910.
2006: Fionnuala McAleese; Shang Wei Wu; Krzysztof Sieradzki; Paul Dunman; Ellen Murphy; Steven Projan; Alexander Tomasz
Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin.
Journal of bacteriology 2006;188(3):1120-33.
2006: Fred C Tenover; Linda McDougal; Richard Goering; George Killgore; Steven Projan; Jean B Patel; Paul Dunman
Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States.
Journal of clinical microbiology 2006;44(1):108-18.
2005: Fionnuala McAleese; Ellen Murphy; Timothy Babinchak; Guy Singh; Battouli Said-Salim; Barry Kreiswirth; Paul Dunman; John O'Connell; Steven Projan; Patricia A Bradford
Use of ribotyping to retrospectively identify methicillin-resistant Staphylococcus aureus isolates from phase 3 clinical trials for tigecycline that are genotypically related to community-associated isolates.
Antimicrobial agents and chemotherapy 2005;49(11):4521-9.
2005: Jiang Wu; Michiko Kobayashi; Eric A Sousa; Wei Liu; Jie Cai; Samuel J Goldman; Andrew J Dorner; Steven Projan; mani kavuru; Yongchang Qiu; Mary Jane Thomassen
Differential proteomic analysis of bronchoalveolar lavage fluid in asthmatics following segmental antigen challenge.
Molecular & cellular proteomics : MCP 2005;4(9):1251-64.
2005: Fionnuala McAleese; Peter Petersen; Alexey Ruzin; Paul Dunman; Ellen Murphy; Steven Projan; Patricia A Bradford
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.
Antimicrobial agents and chemotherapy 2005;49(5):1865-71.
2005: Que Chi Truong-Bolduc; Paul Dunman; Jacob Strahilevitz; Steven Projan; David C Hooper
MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.
Journal of bacteriology 2005;187(7):2395-405.
2005: José M Entenza; Philippe Moreillon; Maria Magdalena Senn; Jan Kormanec; Paul Dunman; Brigitte Berger-Bächi; Steven Projan; Markus Bischoff
Role of sigmaB in the expression of Staphylococcus aureus cell wall adhesins ClfA and FnbA and contribution to infectivity in a rat model of experimental endocarditis.
Infection and immunity 2005;73(2):990-8.
2005: James E Cassat; Paul Dunman; Fionnuala McAleese; Ellen Murphy; Steven Projan; Mark S Smeltzer
Comparative genomics of Staphylococcus aureus musculoskeletal isolates.
Journal of bacteriology 2005;187(2):576-92.
2004: Brian Charles Weinrick; Paul Dunman; Fionnuala McAleese; Ellen Murphy; Steven Projan; Yuan Fang; Richard novick
Effect of mild acid on gene expression in Staphylococcus aureus.
Journal of bacteriology 2004;186(24):8407-23.
2004: William J Weiss; Peter J Petersen; Timothy M Murphy; Luanna Tardio; Youjun Yang; Patricia A Bradford; Aranapakam M Venkatesan; Takao Abe; Takeshi Isoda; Ado Mihira; Hideki Ushirogochi; Tsuyoshi Takasake; Steven Projan; John O'Connell; Tarek S Mansour
In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors.
Antimicrobial agents and chemotherapy 2004;48(12):4589-96.
2004: Steven Projan; David M Shlaes
Antibacterial drug discovery: is it all downhill from here?
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2004;10 Suppl 4():18-22.
2004: Paul Dunman; William Mounts; Fionnuala McAleese; F Immermann; Daphne Macapagal; E Marsilio; Linda McDougal; Fred C Tenover; Patricia A Bradford; Peter J Petersen; Steven Projan; Ellen Murphy
Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis.
Journal of clinical microbiology 2004;42(9):4275-83.
2004: Steven Projan; Davinder Gill; Zhijian Lu; Steven H Herrmann
Small molecules for small minds? The case for biologic pharmaceuticals.
Expert opinion on biological therapy 2004;4(8):1345-50.
2004: Karen E Beenken; Paul Dunman; Fionnuala McAleese; Daphne Macapagal; Ellen Murphy; Steven Projan; Jon S Blevins; Mark S Smeltzer
Global gene expression in Staphylococcus aureus biofilms.
Journal of bacteriology 2004;186(14):4665-84.
2004: Russell G Dushin; Ting-Zhong Wang; Phaik-Eng Sum; Haiyin He; Alan G Sutherland; Joseph S Ashcroft; Edmund I Graziani; Frank E Koehn; Patricia A Bradford; Peter J Petersen; Karen L Wheless; David How; Nancy Torres; Eileen Lenoy; William J Weiss; Stanley A Lang; Steven Projan; David M Shlaes; Tarek S Mansour
Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.
Journal of medicinal chemistry 2004;47(14):3487-90.
2004: Markus Bischoff; Paul Dunman; Jan Kormanec; Daphne Macapagal; Ellen Murphy; William Mounts; Brigitte Berger-Bächi; Steven Projan
Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.
Journal of bacteriology 2004;186(13):4085-99.
2004: Gesine Bauer; Christian Berens; Steven Projan; Wolfgang Hillen
Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA.
The Journal of antimicrobial chemotherapy 2004;53(4):592-9.
2004: William J Weiss; Eileen Lenoy; Timothy Murphy; LuAnna Tardio; Pamela Burgio; Steven Projan; Olaf Schneewind; Lefa Alksne
Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection.
The Journal of antimicrobial chemotherapy 2004;53(3):480-6.
2004: Steven Projan
Phage-inspired antibiotics?
Nature biotechnology 2004;22(2):167-8.
2003: Steven Projan
Why is big Pharma getting out of antibacterial drug discovery?
Current opinion in microbiology 2003;6(5):427-30.
2003: Sugunya Utaida; Paul Dunman; Daphne Macapagal; Ellen Murphy; Steven Projan; Vineet K Singh; Radheshyam K Jayaswal; Brian J Wilkinson
Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon.
Microbiology (Reading, England) 2003;149(Pt 10):2719-32.
2003: Steven A Haney; David Keeney; Lei Chen; Soraya L Moghazeh; Steven Projan; Beth Rasmussen
Increased retention of functional fusions to toxic genes in new two-hybrid libraries of the E. coli strain MG1655 and B. subtilis strain 168 genomes, prepared without passaging through E. coli.
BMC genomics 2003;4(1):36.
2003: Alexey Ruzin; Anatoly Severin; Soraya L Moghazeh; Jerome Etienne; Patricia A Bradford; Steven Projan; David M Shlaes
Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus.
Biochimica et biophysica acta 2003;1621(2):117-21.
2003: Charles R Dean; Melissa A Visalli; Steven Projan; Phaik-Eng Sum; Patricia A Bradford
Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.
Antimicrobial agents and chemotherapy 2003;47(3):972-8.
2003: Melissa A Visalli; Ellen Murphy; Steven Projan; Patricia A Bradford
AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis.
Antimicrobial agents and chemotherapy 2003;47(2):665-9.
2003: Laszlo Papp; David F McNeeley; Steven Projan; Patricia A Bradford; Adam Frost; Mirjana Nesin
Recurrent episodes of shock-like syndrome caused by the same strain of vancomycin-resistant Enterococcus faecium in a pediatric patient.
Microbial drug resistance (Larchmont, N.Y.) 2003;9(3):307-12.
2003: Battouli Saïd-Salim; Paul Dunman; Fionnuala McAleese; Daphne Macapagal; Ellen Murphy; P J McNamara; S Arvidson; Timothy J Foster; Steven Projan; Barry N Kreiswirth
Global regulation of Staphylococcus aureus genes by Rot.
Journal of bacteriology 2003;185(2):610-9.
2002: Steven Projan; Philip J Youngman
Antimicrobials: new solutions badly needed.
Current opinion in microbiology 2002;5(5):463-5.
2002: Steven Projan
New (and not so new) antibacterial targets - from where and when will the novel drugs come?
Current opinion in pharmacology 2002;2(5):513-22.
2002: Peter J Petersen; Patricia A Bradford; William J Weiss; Timothy M Murphy; Phaik-Eng Sum; Steven Projan
In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens.
Antimicrobial agents and chemotherapy 2002;46(8):2595-601.
2002: Alexey Ruzin; Anatoly Severin; Frank Ritacco; Keiko Tabei; Guy Singh; Patricia A Bradford; Marshall M Siegel; Steven Projan; David M Shlaes
Further evidence that a cell wall precursor [C(55)-MurNAc-(peptide)-GlcNAc] serves as an acceptor in a sorting reaction.
Journal of bacteriology 2002;184(8):2141-7.
2002: Maureen DeCenzo; Mike Kuranda; Seth Cohen; John Babiak; Zhi-Dong Jiang; Dongyu Su; Mark Hickey; Praveen Sancheti; Patricia A Bradford; Phil Youngman; Steven Projan; David M Rothstein
Identification of compounds that inhibit late steps of peptidoglycan synthesis in bacteria.
The Journal of antibiotics 2002;55(3):288-95.
2002: Tony Cass; Jim Dunwell; Lawrence P Wackett; Gianfranco Gilardi; Thomas A Kost; Patrick Condreay; Steven Projan; Jeroen Hugenholtz; Michiel Kleerebezem; Nicholas J Turner; Robert E Speight
Biotechnology. Paper Alert.
Current opinion in biotechnology 2002;13(1):1-8.
2002: Paul Hagan; Steven Projan; John Rosamond
Infectious diseases: back to the future?
Trends in microbiology 2002;10(10 Suppl):S1-2.
2002: Steven A Haney; Lefa Alksne; Paul Dunman; Ellen Murphy; Steven Projan
Genomics in anti-infective drug discovery--getting to endgame.
Current pharmaceutical design 2002;8(13):1099-118.
2001: Paul Dunman; E Murphy; S Haney; D Palacios; G Tucker-Kellogg; S Wu; E L Brown; R J Zagursky; David M Shlaes; Steven Projan
Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci.
Journal of bacteriology 2001;183(24):7341-53.
2001: David M Livermore; M Warner; Lucinda M C Hall; Virve I Enne; Steven Projan; Paul Dunman; S L Wooster; G Harrison
Antibiotic resistance in bacteria from magpies (Pica pica) and rabbits (Oryctolagus cuniculus) from west Wales.
Environmental microbiology 2001;3(10):658-61.
2000: Lefa Alksne; Steven Projan
Bacterial virulence as a target for antimicrobial chemotherapy.
Current opinion in biotechnology 2000;11(6):625-36.
2000: Steven Projan
Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent.
Pharmacotherapy 2000;20(9 Pt 2):219S-223S; discussion 224S-228S.
2000: Lefa Alksne; P Burgio; William Hu; Boris Feld; M P Singh; Margareta Tuckman; Peter J Petersen; Pornpen Labthavikul; M McGlynn; Laurel R Barbieri; L McDonald; Patricia A Bradford; Russell G Dushin; D Rothstein; Steven Projan
Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system.
Antimicrobial agents and chemotherapy 2000;44(6):1418-27.
2000: Margareta Tuckman; Peter J Petersen; Steven Projan
Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines.
Microbial drug resistance (Larchmont, N.Y.) 2000;6(4):277-82.
1999: Y Chien; Adhar C Manna; Steven Projan; Ambrose L Cheung
SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation.
The Journal of biological chemistry 1999;274(52):37169-76.
1999: M Ahmad; Carl Urban; Noriel Mariano; Patricia A Bradford; E Calcagni; Steven Projan; Karen Bush; James J Rahal
Clinical characteristics and molecular epidemiology associated with imipenem-resistant Klebsiella pneumoniae.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1999;29(2):352-5.
1998: Phaik-Eng Sum; F W Sum; Steven Projan
Recent developments in tetracycline antibiotics.
Current pharmaceutical design 1998;4(2):119-32.
1997: Patricia A Bradford; Carl Urban; Noriel Mariano; Steven Projan; James J Rahal; Karen Bush
Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein.
Antimicrobial agents and chemotherapy 1997;41(3):563-9.
1995: M Nesin; Steven Projan; Barry N Kreiswirth; Y Bolt; Richard novick
Molecular epidemiology of Staphylococcus epidermidis blood isolates from neonatal intensive care unit patients.
The Journal of hospital infection 1995;31(2):111-21.
1995: Richard novick; Steven Projan; J Kornblum; H F Ross; G Ji; Barry N Kreiswirth; François Vandenesch; Soraya L Moghazeh
The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus.
Molecular & general genetics : MGG 1995;248(4):446-58.
1995: A I Cheung; Steven Projan; R E Edelstein; Vincent Fischetti
Cloning, expression, and nucleotide sequence of a Staphylococcus aureus gene (fbpA) encoding a fibrinogen-binding protein.
Infection and immunity 1995;63(5):1914-20.
1995: Patricia A Bradford; Carl Urban; A Jaiswal; Noriel Mariano; B A Rasmussen; Steven Projan; James J Rahal; Karen Bush
SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients.
Antimicrobial agents and chemotherapy 1995;39(4):899-905.
1994: Steven Projan; S Brown-Skrobot; P M Schlievert; François Vandenesch; Richard novick
Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction.
Journal of bacteriology 1994;176(14):4204-9.
1994: Ambrose L Cheung; Steven Projan
Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr.
Journal of bacteriology 1994;176(13):4168-72.
1994: A Rasooly; Steven Projan; Richard novick
Plasmids of the pT181 family show replication-specific initiator protein modification.
Journal of bacteriology 1994;176(8):2450-3.
1993: Richard novick; H F Ross; Steven Projan; J Kornblum; Barry N Kreiswirth; Soraya L Moghazeh
Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule.
The EMBO journal 1993;12(10):3967-75.
1993: François Vandenesch; Steven Projan; B Kreiswirth; Jerome Etienne; Richard novick
Agr-related sequences in Staphylococcus lugdunensis.
FEMS microbiology letters 1993;111(1):115-22.
1993: T Howard Howell; Joseph P Fiorellini; P Blackburn; Steven Projan; J de la Harpe; Ray C Williams
The effect of a mouthrinse based on nisin, a bacteriocin, on developing plaque and gingivitis in beagle dogs.
Journal of clinical periodontology 1993;20(5):335-9.
1993: P Z Wang; Steven Projan; V Henriquez; Richard novick
Origin recognition specificity in pT181 plasmids is determined by a functionally asymmetric palindromic DNA element.
The EMBO journal 1993;12(1):45-52.
1992: P M Sears; B S Smith; W K Stewart; Ruben N Gonzalez; S D Rubino; S A Gusik; E S Kulisek; Steven Projan; P Blackburn
Evaluation of a nisin-based germicidal formulation on teat skin of live cows.
Journal of dairy science 1992;75(11):3185-90.
1992: Ambrose L Cheung; J M Koomey; C A Butler; Steven Projan; Vincent Fischetti
Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6462-6.
1992: P K Lee; Barry N Kreiswirth; J R Deringer; Steven Projan; William Eisner; B L Smith; E Carlson; Richard novick; Patrick M Schlievert
Nucleotide sequences and biologic properties of toxic shock syndrome toxin 1 from ovine- and bovine-associated Staphylococcus aureus.
The Journal of infectious diseases 1992;165(6):1056-63.
1992: Patrick M Schlievert; J R Deringer; M H Kim; Steven Projan; Richard novick
Effect of glycerol monolaurate on bacterial growth and toxin production.
Antimicrobial agents and chemotherapy 1992;36(3):626-31.
1992: Steven Projan; Richard novick
cis-inhibitory elements in the pT181 replication system.
Plasmid 1992;27(2):81-92.
1992: L Grinius; G Dreguniene; E B Goldberg; C H Liao; Steven Projan
A staphylococcal multidrug resistance gene product is a member of a new protein family.
Plasmid 1992;27(2):119-29.
1992: Gary J Noel; Barry N Kreiswirth; P J Edelson; M Nesin; Steven Projan; William Eisner; D J Bauer; Hermínia de Lencastre; A M sa Figueiredo; Alexander Tomasz
Multiple methicillin-resistant Staphylococcus aureus strains as a cause for a single outbreak of severe disease in hospitalized neonates.
The Pediatric infectious disease journal 1992;11(3):184-8.
1992: P Z Wang; Steven Projan; V Henriquez; Richard novick
Specificity of origin recognition by replication initiator protein in plasmids of the pT181 family is determined by a six amino acid residue element.
Journal of molecular biology 1992;223(1):145-58.
1991: Samuel C Kayman; R Kopelman; Steven Projan; D M Kinney; Abraham Pinter
Mutational analysis of N-linked glycosylation sites of Friend murine leukemia virus envelope protein.
Journal of virology 1991;65(10):5323-32.
1991: P Z Wang; Steven Projan; Richard novick
Nucleotide sequence of beta-lactamase regulatory genes from staphylococcal plasmid pI258.
Nucleic acids research 1991;19(14):4000.
1991: P Z Wang; V B Henriquez; Steven Projan; S Iordanescu; Richard novick
The effect of plasmid copy number mutations on pT181 replication initiator protein expression.
Plasmid 1991;25(3):198-207.
1990: M Nesin; P Svec; J R Lupski; G Nigel Godson; Barry N Kreiswirth; J Kornblum; Steven Projan
Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1990;34(11):2273-6.
1989: Richard novick; S Iordanescu; Steven Projan; J Kornblum; I Edelman
pT181 plasmid replication is regulated by a countertranscript-driven transcriptional attenuator.
Cell 1989;59(2):395-404.
1989: Steven Projan; J Kornblum; Barry N Kreiswirth; Soraya L Moghazeh; William Eisner; Richard novick
Nucleotide sequence: the beta-hemolysin gene of Staphylococcus aureus.
Nucleic acids research 1989;17(8):3305.
1989: Steven Projan; Gordon L Archer
Mobilization of the relaxable Staphylococcus aureus plasmid pC221 by the conjugative plasmid pGO1 involves three pC221 loci.
Journal of bacteriology 1989;171(4):1841-5.
1989: Barry N Kreiswirth; Steven Projan; P M Schlievert; Richard novick
Toxic shock syndrome toxin 1 is encoded by a variable genetic element.
Reviews of infectious diseases 1989;11 Suppl 1():S83-8; discussion S88-9.
1988: S Iordanescu; Steven Projan
Replication termination for staphylococcal plasmids: plasmids pT181 and pC221 cross-react in the termination process.
Journal of bacteriology 1988;170(8):3427-34.
1988: Steven Projan; R Novick
Comparative analysis of five related Staphylococcal plasmids.
Plasmid 1988;19(3):203-21.
1988: Steven Projan; Soraya L Moghazeh; Richard novick
Nucleotide sequence of pS194, a streptomycin-resistance plasmid from Staphylococcus aureus.
Nucleic acids research 1988;16(5):2179-87.
1988: J S Kornblum; Steven Projan; Soraya L Moghazeh; Richard novick
A rapid method to quantitate non-labeled RNA species in bacterial cells.
Gene 1988;63(1):75-85.
1987: Steven Projan; M Monod; C S Narayanan; David Dubnau
Replication properties of pIM13, a naturally occurring plasmid found in Bacillus subtilis, and of its close relative pE5, a plasmid native to Staphylococcus aureus.
Journal of bacteriology 1987;169(11):5131-9.
1987: P Z Wang; Steven Projan; K R Leason; Richard novick
Translational fusion with a secretory enzyme as an indicator.
Journal of bacteriology 1987;169(7):3082-7.
1986: R M Burger; Steven Projan; Susan B. Horwitz; Jack Peisach
The DNA cleavage mechanism of iron-bleomycin. Kinetic resolution of strand scission from base propenal release.
The Journal of biological chemistry 1986;261(34):15955-9.
1986: J R Lupski; Steven Projan; L S Ozaki; G Nigel Godson
A temperature-dependent pBR322 copy number mutant resulting from a Tn5 position effect.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7381-5.
1986: Steven Projan; Richard novick
Incompatibility between plasmids with independent copy control.
Molecular & general genetics : MGG 1986;204(2):341-8.
1985: Steven Projan; J Kornblum; Soraya L Moghazeh; I Edelman; M L Gennaro; Richard novick
Comparative sequence and functional analysis of pT181 and pC221, cognate plasmid replicons from Staphylococcus aureus.
Molecular & general genetics : MGG 1985;199(3):452-64.
1985: Richard novick; Steven Projan; C C Kumar; S Carleton; A Gruss; Sarah Katherine Highlander; J Kornblum
Replication control for pT181, an indirectly regulated plasmid.
Basic life sciences 1985;30():299-320.
1984: Richard novick; G K Adler; Steven Projan; S Carleton; Sarah Katherine Highlander; A Gruss; S A Khan; S Iordanescu
Control of pT181 replication I. The pT181 copy control function acts by inhibiting the synthesis of a replication protein.
The EMBO journal 1984;3(10):2399-405.
1984: S Carleton; Steven Projan; Sarah Katherine Highlander; S M Moghazeh; Richard novick
Control of pT181 replication II. Mutational analysis.
The EMBO journal 1984;3(10):2407-14.
1984: Steven Projan; Richard novick
Reciprocal intrapool variation in plasmid copy numbers: a characteristic of segregational incompatibility.
Plasmid 1984;12(1):52-60.
1984: Richard novick; Steven Projan; W Rosenblum; I Edelman
Staphylococcal plasmid cointegrates are formed by host- and phage-mediated general rec systems that act on short regions of homology.
Molecular & general genetics : MGG 1984;195(1-2):374-7.
1983: Steven Projan; S Carleton; Richard novick
Determination of plasmid copy number by fluorescence densitometry.
Plasmid 1983;9(2):182-90.
1981: Steven Projan; J A Wechsler
Isolation and analysis of multicopy extragenic suppressors of dnaA mutations.
Journal of bacteriology 1981;145(2):861-6.
1981: Steven Projan; J A Wechsler
RNA polymerase is required for DNA initiation in vitro.
Molecular & general genetics : MGG 1981;183(1):78-81.
1981: Steven Projan; J A Wechsler
Initiation of chromosomal DNA synthesis in vitro.
Molecular & general genetics : MGG 1981;182(2):263-7.
1981: Steven Projan; J A Wechsler
Complementation of a dnaC initiation defect in vitro.
Molecular & general genetics : MGG 1981;183(1):74-7.