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Jurgen Lehmann

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Beata Lecka-Czernik; Elena J Moerman; David F Grant; Jurgen Lehmann; Stavros C Manolagas; Robert L Jilka
Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.
Akiko Ueda; Hisham K Hamadeh; Heather K Webb; Yukio Yamamoto; Tatsuya Sueyoshi; Cynthia A Afshari; Jurgen Lehmann; Masahiko Negishi
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital.
Deborah Winegar; PJ Brown; William O Wilkison; Michael C Lewis; R J Ott; WQ Tong; H Roger Brown; Jurgen Lehmann; Steven A Kliewer; Kelli D Plunket; James M Way; Noni L Bodkin; Barbara C Hansen
Effects of fenofibrate on lipid parameters in obese rhesus monkeys.

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2002: Beata Lecka-Czernik; Elena J Moerman; David F Grant; Jurgen Lehmann; Stavros C Manolagas; Robert L Jilka
Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.
Endocrinology 2002;143(6):2376-84.
2002: Akiko Ueda; Hisham K Hamadeh; Heather K Webb; Yukio Yamamoto; Tatsuya Sueyoshi; Cynthia A Afshari; Jurgen Lehmann; Masahiko Negishi
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital.
Molecular pharmacology 2002;61(1):1-6.
2001: Deborah Winegar; PJ Brown; William O Wilkison; Michael C Lewis; R J Ott; WQ Tong; H Roger Brown; Jurgen Lehmann; Steven A Kliewer; Kelli D Plunket; James M Way; Noni L Bodkin; Barbara C Hansen
Effects of fenofibrate on lipid parameters in obese rhesus monkeys.
Journal of lipid research 2001;42(10):1543-51.
2001: A K Shiau; P Coward; M Schwarz; Jurgen Lehmann
Orphan nuclear receptors: from new ligand discovery technologies to novel signaling pathways.
Current opinion in drug discovery & development 2001;4(5):575-90.
2001: P Coward; D Lee; M V Hull; Jurgen Lehmann
4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8880-4.
1999: PJ Brown; Deborah Winegar; Kelli D Plunket; Linda B Moore; Michael C Lewis; Joan G Wilson; Scott S Sundseth; C S Koble; Z Wu; J M Chapman; Jurgen Lehmann; Steven A Kliewer; Timothy M Willson
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Journal of medicinal chemistry 1999;42(19):3785-8.
1999: Kathleen K Brown; Brad R Henke; Steven G Blanchard; Jeffery Cobb; Robert A Mook; Istvan Kaldor; Steven A Kliewer; Jurgen Lehmann; James Lenhard; W Wallace Harrington; P J Novak; Walter L Faison; Jane G Binz; Mir A Hashim; W O Oliver; H Roger Brown; Derek J Parks; Kelli D Plunket; WQ Tong; J A Menius; Kim K Adkison; S A Noble; Timothy M Willson
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Diabetes 1999;48(7):1415-24.
1999: J L Oberfield; Jon L Collins; C P Holmes; D M Goreham; J P Cooper; Jeffery Cobb; James Lenhard; Emily Hull-Ryde; C P Mohr; Steven G Blanchard; Derek J Parks; Linda B Moore; Jurgen Lehmann; Kelli D Plunket; Aaron B Miller; MV Milburn; Steven A Kliewer; Timothy M Willson
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6102-6.
1999: Derek J Parks; Steven G Blanchard; Randy K Bledsoe; G Chandra; Thomas G Consler; Steven A Kliewer; Julie B Stimmel; Timothy M Willson; Ann Marie Zavacki; David D Moore; Jurgen Lehmann
Bile acids: natural ligands for an orphan nuclear receptor.
Science (New York, N.Y.) 1999;284(5418):1365-8.
1999: Steven A Kliewer; Jurgen Lehmann; Timothy M Willson
Orphan nuclear receptors: shifting endocrinology into reverse.
Science (New York, N.Y.) 1999;284(5415):757-60.
1999: H Eric Xu; Millard H Lambert; Valerie G Montana; Derek J Parks; Steven G Blanchard; PJ Brown; Daniel D Sternbach; Jurgen Lehmann; G Bruce Wisely; Timothy M Willson; Steven A Kliewer; MV Milburn
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Molecular cell 1999;3(3):397-403.
1999: Steven A Kliewer; Jurgen Lehmann; MV Milburn; Timothy M Willson
The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways.
Recent progress in hormone research 1999;54():345-67; discussion 367-8.
1998: Jon L Collins; Steven G Blanchard; G Evan Boswell; PS Charifson; Jeffery Cobb; Brad R Henke; Emily Hull-Ryde; Wieslaw M Kazmierski; DH Lake; Lisa M Leesnitzer; Jurgen Lehmann; James Lenhard; Lisa A Orband-Miller; Y Gray-Nunez; Derek J Parks; K D Plunkett; WQ Tong
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
Journal of medicinal chemistry 1998;41(25):5037-54.
1998: Brad R Henke; Steven G Blanchard; M F Brackeen; Kathleen K Brown; Jeffery Cobb; Jon L Collins; W Wallace Harrington; Mir A Hashim; Emily Hull-Ryde; Istvan Kaldor; Steven A Kliewer; DH Lake; Lisa M Leesnitzer; Jurgen Lehmann; James Lenhard; Lisa A Orband-Miller; John F Miller; Robert A Mook; S A Noble; William R Oliver; Derek J Parks; Kelli D Plunket; J R Szewczyk; Timothy M Willson
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Journal of medicinal chemistry 1998;41(25):5020-36.
1998: Jurgen Lehmann; David D McKee; Michael A Watson; Timothy M Willson; John T Moore; Steven A Kliewer
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
The Journal of clinical investigation 1998;102(5):1016-23.
1998: John T Moore; David D McKee; KA Slentz-Kesler; Linda B Moore; Stacey A Jones; Earnest Horne; Jui-Lan Su; Steven A Kliewer; Jurgen Lehmann; Timothy M Willson
Cloning and characterization of human estrogen receptor beta isoforms.
Biochemical and biophysical research communications 1998;247(1):75-8.
1998: Steven A Kliewer; John T Moore; L Wade; Jeff L Staudinger; Michael A Watson; Stacey A Jones; David D McKee; BB Oliver; Timothy M Willson; R H Zetterström; Thomas Perlmann; Jurgen Lehmann
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
Cell 1998;92(1):73-82.
1997: PJ Brown; T A Smith-Oliver; PS Charifson; NC Tomkinson; Adam M Fivush; Daniel D Sternbach; L E Wade; Lisa A Orband-Miller; Derek J Parks; Steven G Blanchard; Steven A Kliewer; Jurgen Lehmann; Timothy M Willson
Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.
Chemistry & biology 1997;4(12):909-18.
1997: James Lenhard; Steven A Kliewer; Mark A Paulik; Kelli D Plunket; Jurgen Lehmann; JE Weiel
Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways.
Biochemical pharmacology 1997;54(7):801-8.
1997: Ann Marie Zavacki; Jurgen Lehmann; W Seol; Timothy M Willson; Steven A Kliewer; David D Moore
Activation of the orphan receptor RIP14 by retinoids.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7909-14.
1997: Steven A Kliewer; Scott S Sundseth; Stacey A Jones; PJ Brown; G Bruce Wisely; C S Koble; P Devchand; W Wahli; Timothy M Willson; James Lenhard; Jurgen Lehmann
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4318-23.
1997: Jurgen Lehmann; James Lenhard; BB Oliver; G M Ringold; Steven A Kliewer
Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.
The Journal of biological chemistry 1997;272(6):3406-10.
1997: Jurgen Lehmann; Steven A Kliewer; Linda B Moore; T A Smith-Oliver; BB Oliver; Jui-Lan Su; Scott S Sundseth; Deborah Winegar; D E Blanchard; Thomas A Spencer; Timothy M Willson
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway.
The Journal of biological chemistry 1997;272(6):3137-40.
1997: Jui-Lan Su; Katherine E Kilpatrick; BR Champion; DC Morris; Jurgen Lehmann; Thomas A Kost
Fluorescent microtiter screening assay for immunocytochemically reactive antibodies.
BioTechniques 1997;22(2):320-4.
1996: Timothy M Willson; Jurgen Lehmann; Steven A Kliewer
Discovery of ligands for the nuclear peroxisome proliferator-activated receptors.
Annals of the New York Academy of Sciences 1996;804():276-83.
1996: T A Tai; C Jennermann; Kathleen K Brown; B B Oliver; M A MacGinnitie; W O Wilkison; H Roger Brown; Jurgen Lehmann; Steven A Kliewer; D C Morris; R A Graves
Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation.
The Journal of biological chemistry 1996;271(47):29909-14.
1996: Jeffrey M Gimble; CE Robinson; Xiaohui Wu; K A Kelly; B R Rodriguez; Steven A Kliewer; Jurgen Lehmann; D C Morris
Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells.
Molecular pharmacology 1996;50(5):1087-94.
1996: Timothy M Willson; Jeffery Cobb; D J Cowan; R W Wiethe; I D Correa; S R Prakash; K D Beck; Linda B Moore; Steven A Kliewer; Jurgen Lehmann
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.
Journal of medicinal chemistry 1996;39(3):665-8.
1995: Steven A Kliewer; James Lenhard; Timothy M Willson; I Patel; D C Morris; Jurgen Lehmann
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.
Cell 1995;83(5):813-9.
1995: Jurgen Lehmann; Linda B Moore; T A Smith-Oliver; W O Wilkison; Timothy M Willson; Steven A Kliewer
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
The Journal of biological chemistry 1995;270(22):12953-6.
1993: Jurgen Lehmann; Xiao-kun Zhang; G Graupner; M O Lee; T Hermann; B Hoffmann; Magnus Pfahl
Formation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching.
Molecular and cellular biology 1993;13(12):7698-707.
1993: Ling Jong; Jurgen Lehmann; Peter D Hobbs; E Harlev; J C Huffman; Magnus Pfahl; Marcia I Dawson
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.
Journal of medicinal chemistry 1993;36(18):2605-13.
1992: Jurgen Lehmann; Ling Jong; A Fanjul; J F Cameron; X P Lu; P Haefner; Marcia I Dawson; Magnus Pfahl
Retinoids selective for retinoid X receptor response pathways.
Science (New York, N.Y.) 1992;258(5090):1944-6.
1992: P Tran; Xiao-kun Zhang; G Salbert; T Hermann; Jurgen Lehmann; Magnus Pfahl
COUP orphan receptors are negative regulators of retinoic acid response pathways.
Molecular and cellular biology 1992;12(10):4666-76.
1992: Jurgen Lehmann; Xiao-kun Zhang; Magnus Pfahl
RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites.
Molecular and cellular biology 1992;12(7):2976-85.
1991: Jurgen Lehmann; Marcia I Dawson; Peter D Hobbs; M Husmann; Magnus Pfahl
Identification of retinoids with nuclear receptor subtype-selective activities.
Cancer research 1991;51(18):4804-9.
1991: Jurgen Lehmann; B Hoffmann; Magnus Pfahl
Genomic organization of the retinoic acid receptor gamma gene.
Nucleic acids research 1991;19(3):573-8.
1990: B Hoffmann; Jurgen Lehmann; Xiao-kun Zhang; T Hermann; M Husmann; G Graupner; Magnus Pfahl
A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter.
Molecular endocrinology (Baltimore, Md.) 1990;4(11):1727-36.
1990: Jurgen Lehmann; G Riethmüller; J P Johnson
Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3.
Nucleic acids research 1990;18(4):1048.
1990: Magnus Pfahl; M Tzukerman; Xiao-kun Zhang; Jurgen Lehmann; T Hermann; K N Wills; G Graupner
Nuclear retinoic acid receptors: cloning, analysis, and function.
Methods in enzymology 1990;189():256-70.
1989: Jurgen Lehmann; B Holzmann; U Rothbächer; Gert Riethmüller; Judith P Johnson
[Step-wise expression of melanoma-associated antigens in tumor progression].
Onkologie 1989;12(6):273-6.
1989: Jurgen Lehmann; Gert Riethmüller; Judith P Johnson
MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9891-5.
1989: Judith P Johnson; Jurgen Lehmann; B G Stade; U Rothbächer; C Sers; Gert Riethmüller
Functional aspects of three molecules associated with metastasis development in human malignant melanoma.
Invasion & metastasis 1989;9(6):338-50.
1988: Judith P Johnson; Jurgen Lehmann; Gert Riethmüller
The tumor progression-associated human melanoma antigen P3.58 mediates monocyte-lymphocyte interactions in vitro.
European journal of immunology 1988;18(12):2097-100.
1988: B Holzmann; Jurgen Lehmann; HW Ziegler-Heitbrock; Ilona Funke; Gert Riethmüller; Judith P Johnson
Glycoprotein P3.58, associated with tumor progression in malignant melanoma, is a novel leukocyte activation antigen.
International journal of cancer. Journal international du cancer 1988;41(4):542-7.
1987: B Holzmann; E B Bröcker; Jurgen Lehmann; D J Ruiter; C Sorg; Gert Riethmüller; Judith P Johnson
Tumor progression in human malignant melanoma: five stages defined by their antigenic phenotypes.
International journal of cancer. Journal international du cancer 1987;39(4):466-71.
1987: Jurgen Lehmann; B Holzmann; E W Breitbart; P Schmiegelow; Gert Riethmüller; Judith P Johnson
Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000.
Cancer research 1987;47(3):841-5.