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Donald Heppner

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Chemicals & Drugs

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Amed Ouattara; SAYE Renion; Lorraine Soisson; Shannon Takala-Harrison; Mahamadou A Thera; Youssouf Tolo; Johan Vekemans; William C Blackwelder; Joe Cohen; Drissa Coulibaly; Carter L Diggs; Ogobara K Doumbo; Tina Dube; Sheetij Dutta; Donald Heppner; Matthew B Laurens; Amadou Niangaly; Christopher Plowe
Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications.
James F Cummings; Michele D Spring; Robert Schwenk; Christian F Ockenhouse; Kent Kester; Mark E Polhemus; Douglas S Walsh; In-Kyu Yoon; Christine Prosperi; Laure Y Juompan; David Lanar; Urszula Krzych; B Ted Hall; Lisa A Ware; V Ann Stewart; Jack Williams; Megan G Dowler; Robin K Nielsen; Collette J Hillier; Birgitte K Giersing; Filip Dubovsky; Elissa Malkin; Kathryn Tucker; Marie-Claude Dubois; Joe D Cohen; W Ripley Ballou; Donald Heppner
Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection.
Maryanne Vahey; Zhining Wang; Kent Kester; James Cummings; Donald Heppner; Martin E Nau; Opokua Ofori-Anyinam; Joe Cohen; Thierry Coche; W Ripley Ballou; Christian F Ockenhouse
Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.

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All Publications

2013: Amed Ouattara; SAYE Renion; Lorraine Soisson; Shannon Takala-Harrison; Mahamadou A Thera; Youssouf Tolo; Johan Vekemans; William C Blackwelder; Joe Cohen; Drissa Coulibaly; Carter L Diggs; Ogobara K Doumbo; Tina Dube; Sheetij Dutta; Donald Heppner; Matthew B Laurens; Amadou Niangaly; Christopher Plowe
Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications.
The Journal of infectious diseases 2013;207(3):511-9.
2010: James F Cummings; Michele D Spring; Robert Schwenk; Christian F Ockenhouse; Kent Kester; Mark E Polhemus; Douglas S Walsh; In-Kyu Yoon; Christine Prosperi; Laure Y Juompan; David Lanar; Urszula Krzych; B Ted Hall; Lisa A Ware; V Ann Stewart; Jack Williams; Megan G Dowler; Robin K Nielsen; Collette J Hillier; Birgitte K Giersing; Filip Dubovsky; Elissa Malkin; Kathryn Tucker; Marie-Claude Dubois; Joe D Cohen; W Ripley Ballou; Donald Heppner
Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection.
Vaccine 2010;28(31):5135-44.
2010: Maryanne Vahey; Zhining Wang; Kent Kester; James Cummings; Donald Heppner; Martin E Nau; Opokua Ofori-Anyinam; Joe Cohen; Thierry Coche; W Ripley Ballou; Christian F Ockenhouse
Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.
The Journal of infectious diseases 2010;201(4):580-9.
2009: Sathit Pichyangkul; Pongsri Tongtawe; Utaiwan Kum-arb; Kosol Yongvanitchit; Montip Gettayacamin; M R Hollingdale; A Limsalakpetch; V Ann Stewart; David Lanar; S Dutta; Evelina Angov; L A Ware; Elke Bergmann-Leitner; B House; Gerald Voss; M C Dubois; Joe D Cohen; M M Fukuda; Donald Heppner; R Scott Miller
Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS,S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys.
Vaccine 2009;28(2):452-62.
2009: Kent Kester; James F Cummings; Opokua Ofori-Anyinam; Christian F Ockenhouse; Urszula Krzych; Philippe Moris; Robert Schwenk; Robin A Nielsen; Zufan Debebe; Evgeny Pinelis; Laure Juompan; Jack Williams; Megan G Dowler; V Ann Stewart; Robert A Wirtz; Marie-Claude Dubois; Marc Lievens; Joe Cohen; W Ripley Ballou; Donald Heppner
Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection.
The Journal of infectious diseases 2009;200(3):337-46.
2009: Kirsten E Lyke; Modibo Daou; Issa Diarra; Abdoulaye Kone; Bourema Kouriba; Mahamadou A Thera; Sheetij Dutta; David Lanar; Donald Heppner; Ogobara K Doumbo; Christopher Plowe; Marcelo B Sztein
Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: results of a Phase I randomized trial.
Vaccine 2009;27(15):2171-6.
2009: Sheetij Dutta; JoAnn S Sullivan; Katharine K Grady; J David Haynes; Jack Komisar; Adrian H Batchelor; Lorraine Soisson; Carter L Diggs; Donald Heppner; David Lanar; William E Collins; John W Barnwell
High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model.
PloS one 2009;4(12):e8138.
2009: John N Waitumbi; Samuel B Anyona; Carol W Hunja; Carolyne M Kifude; Mark E Polhemus; Douglas S Walsh; Chris F Ockenhouse; Donald Heppner; Amanda Leach; Marc Lievens; W Ripley Ballou; Joe D Cohen; Colin J Sutherland
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
PloS one 2009;4(11):e7849.
2009: Bernhards R Ogutu; Odika J Apollo; Denise McKinney; Willis Okoth; Joram Siangla; Filip Dubovsky; Kathryn Tucker; John N Waitumbi; Carter L Diggs; Janet Wittes; Elissa Malkin; Amanda Leach; Lorraine A Soisson; Jessica B Milman; Lucas Otieno; Carolyn A Holland; Mark Polhemus; Shon A Remich; Christian F Ockenhouse; Joe Cohen; W Ripley Ballou; Samuel K Martin; Evelina Angov; V Ann Stewart; Jeffrey A Lyon; Donald Heppner; Mark R Withers
Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya.
PloS one 2009;4(3):e4708.
2008: Joseph P Shott; Shannon M McGrath; Maria G Pau; Jerome H H V Custers; Olga Ophorst; Marie-Ange Demoitié; Marie-Claude Dubois; Jack Komisar; Michelle Cobb; Kent Kester; Patrice Dubois; Joe Cohen; Jaap Goudsmit; Donald Heppner; V Ann Stewart
Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-gamma and antibody responses in mice.
Vaccine 2008;26(23):2818-23.
2008: Kent Kester; James F Cummings; Christian F Ockenhouse; Robin Nielsen; B Ted Hall; Daniel M Gordon; Robert Schwenk; Urszula Krzych; Carolyn A Holland; Gregory Richmond; Megan G Dowler; Jackie Williams; Robert A Wirtz; Nadia Tornieporth; Laurence Vigneron; Martine Delchambre; Marie-Ange Demoitie; W Ripley Ballou; Joe Cohen; Donald Heppner
Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research.
Vaccine 2008;26(18):2191-202.
2008: Mark E Polhemus; Shon Remich; Bernhards R Ogutu; John Waitumbi; Marc Lievens; W Ripley Ballou; Donald Heppner
Malaria treatment with atovaquone-proguanil in malaria-immune adults: implications for malaria intervention trials and for pre-exposure prophylaxis of malaria.
Antimicrobial agents and chemotherapy 2008;52(4):1493-5.
2008: Pascal Mettens; Patrice M Dubois; Marie-Ange Demoitié; Babak Bayat; Marie-Noëlle Donner; Patricia Bourguignon; V Ann Stewart; Donald Heppner; Nathalie Garçon; Joe Cohen
Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen.
Vaccine 2008;26(8):1072-82.
2008: V Ann Stewart; Shannon McGrath; Arthur M Krieg; Noelle S Larson; Evelina Angov; Christopher L Smith; Thomas G Brewer; Donald Heppner
Activation of innate immunity in healthy Macaca mulatta macaques by a single subcutaneous dose of GMP CpG 7909: safety data and interferon-inducible protein-10 kinetics for humans and macaques.
Clinical and vaccine immunology : CVI 2008;15(2):221-6.
2008: Sathit Pichyangkul; Utaiwan Kum-arb; Kosol Yongvanitchit; A Limsalakpetch; Montip Gettayacamin; David Lanar; Lisa A Ware; V Ann Stewart; Donald Heppner; Pascal Mettens; Joe D Cohen; W Ripley Ballou; M M Fukuda
Preclinical evaluation of the safety and immunogenicity of a vaccine consisting of Plasmodium falciparum liver-stage antigen 1 with adjuvant AS01B administered alone or concurrently with the RTS,S/AS01B vaccine in rhesus primates.
Infection and immunity 2008;76(1):229-38.
2007: John N Waitumbi; Carolyne M Kifude; Mark R Withers; Mark E Polhemus; Donald Heppner; Bernhards R Ogutu
Hb G-Philadelphia or Stanleyville II? When the phenotype and genotype do not agree.
European journal of haematology 2007;79(2):177-8.
2007: Kent Kester; Denise McKinney; Nadia Tornieporth; Christian F Ockenhouse; Donald Heppner; Ted Hall; Bruce T Wellde; Kate White; Peifang Sun; Robert Schwenk; Urszula Krzych; Martine Delchambre; Gerald Voss; Marie-Claude Dubois; Robert A Gasser; Megan G Dowler; Megan O'Brien; Janet Wittes; Robert A Wirtz; Joe Cohen; W Ripley Ballou
A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naïve adults.
Vaccine 2007;25(29):5359-66.
2007: Donald Heppner; Robert Schwenk; David Arnot; Robert W Sauerwein; Adrian J F Luty
The dog that did not bark: malaria vaccines without antibodies.
Trends in parasitology 2007;23(7):293-6.
2007: Mark E Polhemus; Alan J Magill; James F Cummings; Kent Kester; Christian F Ockenhouse; David Lanar; Sheetij Dutta; Arnoldo Barbosa; Lorraine Soisson; Carter L Diggs; Sally A Robinson; J David Haynes; V Ann Stewart; Lisa A Ware; Clara Brando; Urszula Krzych; Robert A Bowden; Joe D Cohen; Marie-Claude Dubois; Opokua Ofori-Anyinam; Els De-Kock; W Ripley Ballou; Donald Heppner
Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research.
Vaccine 2007;25(21):4203-12.
2007: V Ann Stewart; Shannon M McGrath; Patrice M Dubois; Maria G Pau; Pascal Mettens; Joseph Shott; Michelle Cobb; J Robert Burge; David Larson; Lisa A Ware; Marie-Ange Demoitie; Gerrit Jan Weverling; Babak Bayat; Jerome H H V Custers; Marie-Claude Dubois; Joe Cohen; Jaap Goudsmit; Donald Heppner
Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone.
Infection and immunity 2007;75(5):2283-90.
2007: Clara Brando; Lisa A Ware; Helen Freyberger; April Kathcart; Arnoldo Barbosa; Sylvie Cayphas; Marie-Ange Demoitie; Pascal Mettens; Donald Heppner; David Lanar
Murine immune responses to liver-stage antigen 1 protein FMP011, a malaria vaccine candidate, delivered with adjuvant AS01B or AS02A.
Infection and immunity 2007;75(2):838-45.
2007: Jose Stoute; Joash Gombe; Mark R Withers; Joram Siangla; Denise McKinney; Melanie Onyango; James F Cummings; Jessica Milman; Kathryn Tucker; Lorraine Soisson; V Ann Stewart; Jeffrey A Lyon; Evelina Angov; Amanda Leach; Joe Cohen; Kent Kester; Christian F Ockenhouse; Carolyn A Holland; Carter L Diggs; Janet Wittes; Donald Heppner
Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adults in western Kenya.
Vaccine 2007;25(1):176-84.
2007: Carolyne M Kifude; Mark E Polhemus; Donald Heppner; Mark R Withers; Bernhards R Ogutu; John N Waitumbi
Hb Kenya among Luo adults and young children in malaria holoendemic Western Kenya: screened by high performance liquid chromatography and confirmed by polymerase chain reaction.
Hemoglobin 2007;31(4):401-8.
2007: Eusebio Macete; John J Aponte; Caterina Guinovart; Jahit Sacarlal; Opokua Ofori-Anyinam; Inacio Mandomando; Mateu Espasa; C Bevilacqua; Amanda Leach; Marie-Claude Dubois; Donald Heppner; L Tello; Jessica Milman; Joe Cohen; Filip Dubovsky; Nadia Tornieporth; Ricardo Thompson; Pedro L Alonso
Safety and immunogenicity of the RTS,S/AS02A candidate malaria vaccine in children aged 1-4 in Mozambique.
Tropical medicine & international health : TM & IH 2007;12(1):37-46.
2006: V Ann Stewart; Douglas S Walsh; Shannon M McGrath; Kent Kester; James F Cummings; Gerald Voss; Martine Delchambre; Nathalie Garçon; Joe D Cohen; Donald Heppner
Cutaneous delayed-type hypersensitivity (DTH) in a multi-formulation comparator trial of the anti-falciparum malaria vaccine candidate RTS,S in rhesus macaques.
Vaccine 2006;24(42-43):6493-502.
2006: V Ann Stewart; Shannon M McGrath; Douglas S Walsh; Stacey Davis; Aaron S Hess; Lisa A Ware; Kent Kester; James F Cummings; J Robert Burge; Gerald Voss; Martine Delchambre; Nathalie Garçon; Douglas B Tang; Joe D Cohen; Donald Heppner
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.
Vaccine 2006;24(42-43):6483-92.
2006: Christian F Ockenhouse; Wan-chung Hu; Kent Kester; James F Cummings; Ann Stewart; Donald Heppner; Anne E Jedlicka; Alan L Scott; Nathan D Wolfe; Maryanne Vahey; Donald S. Burke
Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria.
Infection and immunity 2006;74(10):5561-73.
2006: Jose Stoute; Donald Heppner; Carl Mason; Joram Siangla; Malachi O Opollo; Kent Kester; Laurence Vigneron; Gerald Voss; Michael J Walter; Nadia Tornieporth; Joe D Cohen; W Ripley Ballou
Phase 1 safety and immunogenicity trial of malaria vaccine RTS,S/AS02A in adults in a hyperendemic region of western Kenya.
The American journal of tropical medicine and hygiene 2006;75(1):166-70.
2006: Douglas S Walsh; Montip Gettayacamin; Wolfgang W Leitner; Jeffrey A Lyon; V Ann Stewart; Gary Marit; Sathit Pichyangkul; Panita Gosi; Pongsri Tongtawe; Kent Kester; Carolyn A Holland; Nelly Kolodny; Joe Cohen; Gerald Voss; W Ripley Ballou; Donald Heppner
Heterologous prime-boost immunization in rhesus macaques by two, optimally spaced particle-mediated epidermal deliveries of Plasmodium falciparum circumsporozoite protein-encoding DNA, followed by intramuscular RTS,S/AS02A.
Vaccine 2006;24(19):4167-78.
2006: Susanna Dunachie; Michael Walther; Jenni M Vuola; Daniel P Webster; Sheila Keating; Tamara Berthoud; Laura Andrews; Philip Bejon; Ian Poulton; Geoffrey Butcher; Kate Watkins; Robert E Sinden; Amanda Leach; Philippe Moris; Nadia Tornieporth; Joerg Schneider; Filip Dubovsky; Eveline Tierney; Jack Williams; Donald Heppner; Sarah Gilbert; Joe Cohen; Adrian V S Hill
A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.
Vaccine 2006;24(15):2850-9.
2006: Christian F Ockenhouse; Evelina Angov; Kent Kester; Carter L Diggs; Lorraine Soisson; James F Cummings; Ann V Stewart; Dupeh R Palmer; Babita Mahajan; Urszula Krzych; Nadia Tornieporth; Martine Delchambre; M Vanhandenhove; Opokua Ofori-Anyinam; Joe Cohen; Jeffrey A Lyon; Donald Heppner
Phase I safety and immunogenicity trial of FMP1/AS02A, a Plasmodium falciparum MSP-1 asexual blood stage vaccine.
Vaccine 2006;24(15):3009-17.
2006: Mahamadou A Thera; Ogobara K Doumbo; Drissa Coulibaly; Dapa A Diallo; Issaka Sagara; Alassane Dicko; David J Diemert; Donald Heppner; V Ann Stewart; Evelina Angov; Lorraine Soisson; Amanda Leach; Kathryn Tucker; Kirsten E Lyke; Christopher Plowe
Safety and allele-specific immunogenicity of a malaria vaccine in Malian adults: results of a phase I randomized trial.
PLoS clinical trials 2006;1(7):e34.
2006: Mark R Withers; Denise McKinney; Bernhards R Ogutu; John N Waitumbi; Jessica Milman; Odika J Apollo; Otieno G Allen; Kathryn Tucker; Lorraine Soisson; Carter L Diggs; Amanda Leach; Janet Wittes; Filip Dubovsky; V Ann Stewart; Shon A Remich; Joe Cohen; W Ripley Ballou; Carolyn A Holland; Jeffrey A Lyon; Evelina Angov; Jose Stoute; Samuel K Martin; Donald Heppner
Safety and reactogenicity of an MSP-1 malaria vaccine candidate: a randomized phase Ib dose-escalation trial in Kenyan children.
PLoS clinical trials 2006;1(7):e32.
2005: Donald Heppner; Douglas S Walsh; Nichapat Uthaimongkol; Douglas B Tang; Somchit Tulyayon; Barnyen Permpanich; Theera Wimonwattrawatee; Niphon Chuanak; Anintita Laoboonchai; Prasit Sookto; Thomas G Brewer; Philip McDaniel; Chirapa Eamsila; Kosol Yongvanitchit; Kathleen Uhl; Dennis E Kyle; Lisa W Keep; Robert E Miller; Chansuda Wongsrichanalai
Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand.
The American journal of tropical medicine and hygiene 2005;73(5):842-9.
2005: Kalifa Bojang; Folasade Olodude; Margaret Pinder; Opokua Ofori-Anyinam; Laurence Vigneron; Steve Fitzpatrick; Fanta Njie; Adams Kassanga; Amanda Leach; Jessica Milman; Regina Rabinovich; Keith P W J McAdam; Kent Kester; Donald Heppner; Joe D Cohen; Nadia Tornieporth; Paul Milligan
Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children.
Vaccine 2005;23(32):4148-57.
2005: In-Kyu Yoon; Evelina Angov; David Larson; Donald Heppner; James F Cummings; V Ann Stewart
Characterization of a human reference standard for antibody to Plasmodium falciparum merozoite surface protein 1(42).
The American journal of tropical medicine and hygiene 2005;72(6):714-8.
2005: Collette J Hillier; Lisa A Ware; Arnoldo Barbosa; Evelina Angov; Jeffrey A Lyon; Donald Heppner; David Lanar
Process development and analysis of liver-stage antigen 1, a preerythrocyte-stage protein-based vaccine for Plasmodium falciparum.
Infection and immunity 2005;73(4):2109-15.
2004: Douglas S Walsh; Polrat Wilairatana; Douglas B Tang; Donald Heppner; Thomas G Brewer; Srivicha Krudsood; Udomsak Silachamroon; Weerapong Phumratanaprapin; Duangsuda Siriyanonda; Sornchai Looareesuwan
Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(8):1095-103.
2004: Sathit Pichyangkul; Montip Gettayacamin; R Scott Miller; Jeffrey A Lyon; Evelina Angov; Pongsri Tongtawe; David L Ruble; Donald Heppner; Kent Kester; W Ripley Ballou; Carter L Diggs; Gerald Voss; Joe D Cohen; Douglas S Walsh
Pre-clinical evaluation of the malaria vaccine candidate P. falciparum MSP1(42) formulated with novel adjuvants or with alum.
Vaccine 2004;22(29-30):3831-40.
2004: W Ripley Ballou; Myriam Arevalo-Herrera; Daniel J Carucci; Thomas L Richie; Giampietro Corradin; Carter L Diggs; Pierre Druilhe; Birgitte K Giersing; Allan Saul; Donald Heppner; Kent Kester; David Lanar; Jeff Lyon; Adrian V S Hill; Weiqing Pan; Joe D Cohen
Update on the clinical development of candidate malaria vaccines.
The American journal of tropical medicine and hygiene 2004;71(2 Suppl):239-47.
2004: Douglas S Walsh; Sathit Pichyangkul; Montip Gettayacamin; Pongsri Tongtawe; Claire-Anne Siegrist; Pranee Hansukjariya; Kent Kester; Carolyn A Holland; Gerald Voss; Joe Cohen; Ann V Stewart; R Scott Miller; W Ripley Ballou; Donald Heppner
Safety and immunogenicity of rts,s+trap malaria vaccine, formulated in the as02a adjuvant system, in infant rhesus monkeys.
The American journal of tropical medicine and hygiene 2004;70(5):499-509.
2004: Ruobing Wang; Judith Epstein; Yupin Charoenvit; Fe Maria Baraceros; Nancy Rahardjo; Tanya Gay; Jo-Glenna Banania; Rana Chattopadhyay; Patricia de la Vega; Thomas L Richie; Nadia Tornieporth; Denise L Doolan; Kent Kester; Donald Heppner; Jon Norman; Daniel J Carucci; Joe D Cohen; Stephen L Hoffman
Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5561-9.
2004: Judith E Epstein; Yupin Charoenvit; Kent Kester; Ruobing Wang; Rhonda Newcomer; Steve Fitzpatrick; Thomas L Richie; Nadia Tornieporth; Donald Heppner; Christian F Ockenhouse; Victoria Majam; Carolyn Holland; Esteban Abot; Harini Ganeshan; Mara Berzins; Trevor Jones; C Nicole Freydberg; Jennifer Ng; Jon Norman; Daniel J Carucci; Joe Cohen; Stephen L Hoffman
Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A.
Vaccine 2004;22(13-14):1592-603.
2004: Sathit Pichyangkul; Kosol Yongvanitchit; Utaiwan Kum-arb; Hiroaki Hemmi; Shizuo Akira; Arthur M Krieg; Donald Heppner; V Ann Stewart; Hitoshi Hasegawa; Sornchai Looareesuwan; G Dennis Shanks; R Scott Miller
Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4926-33.
2003: Peifang Sun; Robert Schwenk; Katherine White; Jose Stoute; Joe Cohen; W Ripley Ballou; Gerald Voss; Kent Kester; Donald Heppner; Urszula Krzych
Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6961-7.
2003: Chakrit Hirunpetcharat; Jiraprapa Wipasa; S Sakkhachornphop; T Nitkumhan; Y Z Zheng; Sathit Pichyangkul; A M Krieg; Douglas S Walsh; Donald Heppner; Michael F Good
CpG oligodeoxynucleotide enhances immunity against blood-stage malaria infection in mice parenterally immunized with a yeast-expressed 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (MSP1(19)) formulated in oil-based Montanides.
Vaccine 2003;21(21-22):2923-32.
2003: J Russ Forney; Chansuda Wongsrichanalai; Alan J Magill; Leslie G Craig; Jeeraphat Sirichaisinthop; Christian T Bautista; R Scott Miller; Christian F Ockenhouse; Kent Kester; Naomi E Aronson; Ellen M Andersen; Higinio A Quino-Ascurra; Carlos Vidal; Kimberly A Moran; Clinton Murray; Caroline Cady DeWitt; Donald Heppner; Kevin Kain; W Ripley Ballou; Robert A Gasser
Devices for rapid diagnosis of Malaria: evaluation of prototype assays that detect Plasmodium falciparum histidine-rich protein 2 and a Plasmodium vivax-specific antigen.
Journal of clinical microbiology 2003;41(6):2358-66.
2003: Samuel J McConkey; William H H Reece; Vasee S Moorthy; Daniel Webster; Susanna Dunachie; Geoffrey Butcher; Jenni M Vuola; Tom J Blanchard; Philip K Gothard; Kate Watkins; Carolyn M Hannan; Simone Everaere; Karen Brown; Kent Kester; James Cummings; Jackie Williams; Donald Heppner; Ansar A Pathan; Katie L Flanagan; Nirmalan Arulanantham; Mark T M Roberts; Michael Roy; Geoffrey L Smith; Joerg Schneider; T E A Peto; Robert E Sinden; Sarah Gilbert; Adrian V S Hill
Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans.
Nature medicine 2003;9(6):729-35.
2003: Evelina Angov; Barbara M Aufiero; Ann Marie Turgeon; Michel Van Handenhove; Christian F Ockenhouse; Kent Kester; Douglas S Walsh; Jana S McBride; Marie-Claude Dubois; Joe Cohen; J David Haynes; Kenneth H Eckels; Donald Heppner; W Ripley Ballou; Carter L Diggs; Jeffrey A Lyon
Development and pre-clinical analysis of a Plasmodium falciparum Merozoite Surface Protein-1(42) malaria vaccine.
Molecular and biochemical parasitology 2003;128(2):195-204.
2003: Nathalie Garçon; Donald Heppner; Joe Cohen
Development of RTS,S/AS02: a purified subunit-based malaria vaccine candidate formulated with a novel adjuvant.
Expert review of vaccines 2003;2(2):231-8.
2003: Robert Schwenk; Ludmila V Asher; Isaac Chalom; David Lanar; Peifang Sun; Katherine White; Deborah Keil; Kent Kester; Jose Stoute; Donald Heppner; Urszula Krzych
Opsonization by antigen-specific antibodies as a mechanism of protective immunity induced by Plasmodium falciparum circumsporozoite protein-based vaccine.
Parasite immunology 2003;25(1):17-25.
2002: Sheetij Dutta; P V Lalitha; Lisa A Ware; Arnoldo Barbosa; J Kathleen Moch; Meredith A Vassell; Bader B Fileta; Svetlana Kitov; Nelly Kolodny; Donald Heppner; J David Haynes; David Lanar
Purification, characterization, and immunogenicity of the refolded ectodomain of the Plasmodium falciparum apical membrane antigen 1 expressed in Escherichia coli.
Infection and immunity 2002;70(6):3101-10.
2002: Stephen L Hoffman; Lucy M L Goh; Thomas Luke; Imogene Schneider; Thong P Le; Denise L Doolan; John B Sacci; Patricia de la Vega; Megan G Dowler; Chris Paul; Daniel M Gordon; Jose Stoute; L.W. Preston Church; Martha Sedegah; Donald Heppner; W Ripley Ballou; Thomas L Richie
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.
The Journal of infectious diseases 2002;185(8):1155-64.
2002: W Ripley Ballou; Kent Kester; Donald Heppner
Pre-erythrocytic malaria vaccines to prevent Plasmodium falciparum malaria.
Chemical immunology 2002;80():253-61.
2001: Donald Heppner; James F Cummings; Christian F Ockenhouse; Kent Kester; Jeffrey A Lyon; D M Gordon
New World monkey efficacy trials for malaria vaccine development: critical path or detour?
Trends in parasitology 2001;17(9):419-25.
2001: J Russ Forney; Alan J Magill; Chansuda Wongsrichanalai; Jeeraphat Sirichaisinthop; Christian T Bautista; Donald Heppner; R Scott Miller; Christian F Ockenhouse; A Gubanov; R Shafer; C C DeWitt; H A Quino-Ascurra; Kent Kester; Kevin Kain; Douglas S Walsh; W Ripley Ballou; Robert A Gasser
Malaria rapid diagnostic devices: performance characteristics of the ParaSight F device determined in a multisite field study.
Journal of clinical microbiology 2001;39(8):2884-90.
2001: Sathit Pichyangkul; P Saengkrai; Kosol Yongvanitchit; C Limsomwong; Montip Gettayacamin; Douglas S Walsh; V Ann Stewart; W Ripley Ballou; Donald Heppner
Isolation and characterization of rhesus blood dendritic cells using flow cytometry.
Journal of immunological methods 2001;252(1-2):15-23.
2001: Kovit Pattanapanyasat; K Kotipun; Kosol Yongvanitchit; R C Hider; Dennis E Kyle; Donald Heppner; Douglas S Walsh
Effects of hydroxypyridinone iron chelators in combination with antimalarial drugs on the in vitro growth of Plasmodium falciparum.
The Southeast Asian journal of tropical medicine and public health 2001;32(1):64-9.
2001: Kent Kester; Denise McKinney; Nadia Tornieporth; Christian F Ockenhouse; Donald Heppner; Ted Hall; Urszula Krzych; Martine Delchambre; Gerald Voss; Megan G Dowler; J Palensky; Janet Wittes; Joe Cohen; W Ripley Ballou
Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria.
The Journal of infectious diseases 2001;183(4):640-7.
2001: Sathit Pichyangkul; Kosol Yongvanitchit; Utaiwan Kum-arb; A M Krieg; Donald Heppner; Douglas S Walsh
Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotides.
Journal of immunological methods 2001;247(1-2):83-94.
2000: Alan Brockman; Ric Price; Michele van Vugt; Donald Heppner; D Walsh; Prasit Sookto; Theera Wimonwattrawatee; Sornchai Looareesuwan; N J White; François Nosten
Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(5):537-44.
1999: Chansuda Wongsrichanalai; Niphon Chuanak; S Tulyayon; N Thanoosingha; Anintita Laoboonchai; Krongthong Thimasarn; Thomas G Brewer; Donald Heppner
Comparison of a rapid field immunochromatographic test to expert microscopy for the detection of Plasmodium falciparum asexual parasitemia in Thailand.
Acta tropica 1999;73(3):263-73.
1999: Douglas S Walsh; Sornchai Looareesuwan; Polrat Wilairatana; Donald Heppner; Douglas B Tang; Thomas G Brewer; Watcharee Chokejindachai; Parnpen Viriyavejakul; Dennis E Kyle; Wilbur K Milhous; BG Schuster; Richard John Horton; David Braitman; RP Brueckner
Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand.
The Journal of infectious diseases 1999;180(4):1282-7.
1999: W Ripley Ballou; Kent Kester; Jose Stoute; Donald Heppner
Malaria vaccines: triumphs or tribulations?
Parassitologia 1999;41(1-3):403-8.
1999: Donald Heppner; Robert A Gasser; Kent Kester
Primaquine prophylaxis against malaria.
Annals of internal medicine 1999;130(6):536; author reply 536-7.
1999: Ric Price; Julie A Simpson; P Teja-Isavatharm; M M Than; Christine Luxemburger; Donald Heppner; Tan Chongsuphajaisiddhi; François Nosten; Nicholas J White
Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria.
Antimicrobial agents and chemotherapy 1999;43(2):341-6.
1999: Chansuda Wongsrichanalai; Theera Wimonwattrawatee; Prasit Sookto; Anintita Laoboonchai; Donald Heppner; Dennis E Kyle; Walther H Wernsdorfer
In vitro sensitivity of Plasmodium falciparum to artesunate in Thailand.
Bulletin of the World Health Organization 1999;77(5):392-8.
1998: Donald Heppner; W Ripley Ballou
Malaria in 1998: advances in diagnosis, drugs and vaccine development.
Current opinion in infectious diseases 1998;11(5):519-30.
1998: Arunee Sabchareon; Phanorsi Attanath; Pornthep Chanthavanich; P Phanuaksook; V Prarinyanupharb; Y Poonpanich; D Mookmanee; Paktiya Teja-Isavadharm; Donald Heppner; Thomas G Brewer; Tan Chongsuphajaisiddhi
Comparative clinical trial of artesunate suppositories and oral artesunate in combination with mefloquine in the treatment of children with acute falciparum malaria.
The American journal of tropical medicine and hygiene 1998;58(1):11-6.
1997: Sathit Pichyangkul; P Saengkrai; Kosol Yongvanitchit; Donald Heppner; Dennis E Kyle; H Kyle Webster
Regulation of leukocyte adhesion molecules CD11b/CD18 and leukocyte adhesion molecule-1 on phagocytic cells activated by malaria pigment.
The American journal of tropical medicine and hygiene 1997;57(4):383-8.
1997: Sricharoen Migasena; Donald Heppner; Dennis E Kyle; Tan Chongsuphajaisiddhi; Daniel M Gordon; Pravan Suntharasamai; Barnyen Permpanich; Alan Brockman; P Pitiuttutham; Chansuda Wongsrichanalai; P Srisuriya; Benjaluck Phonrat; K Pavanand; C Viravan; W Ripley Ballou
SPf66 malaria vaccine is safe and immunogenic in malaria naive adults in Thailand.
Acta tropica 1997;67(3):215-27.
1997: Sathit Pichyangkul; P Saengkrai; Kosol Yongvanitchit; A Stewart; Donald Heppner
Activation of gammadelta T cells in malaria: interaction of cytokines and a schizont-associated Plasmodium falciparum antigen.
The Journal of infectious diseases 1997;176(1):233-41.
1997: François Nosten; Christine Luxemburger; Dennis E Kyle; Daniel M Gordon; W Ripley Ballou; J C Sadoff; Alan Brockman; Barnyen Permpanich; Tan Chongsuphajaisiddhi; Donald Heppner
Phase I trial of the SPf66 malaria vaccine in a malaria-experienced population in Southeast Asia.
The American journal of tropical medicine and hygiene 1997;56(5):526-32.
1997: Chansuda Wongsrichanalai; T D Nguyen; N T Trieu; Theera Wimonwattrawatee; Prasit Sookto; Donald Heppner; Fumihiko Kawamoto
In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials.
Acta tropica 1997;63(2-3):151-8.
1997: Jose Stoute; Moncef Slaoui; Donald Heppner; P Momin; Kent Kester; P Desmons; Bruce T Wellde; Nathalie Garçon; Urszula Krzych; M Marchand
A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group.
The New England journal of medicine 1997;336(2):86-91.
1996: Kovit Pattanapanyasat; Kosol Yongvanitchit; Donald Heppner; pongsri tongtawe; Dennis E Kyle; H Kyle Webster
Culture of malaria parasites in two different red blood cell populations using biotin and flow cytometry.
Cytometry 1996;25(3):287-94.
1996: François Nosten; Christine Luxemburger; Dennis E Kyle; W Ripley Ballou; J Wittes; E Wah; Tan Chongsuphajaisiddhi; Daniel M Gordon; Nicholas J White; J C Sadoff; Donald Heppner
Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand. Shoklo SPf66 Malaria Vaccine Trial Group.
Lancet 1996;348(9029):701-7.
1996: Donald Heppner; Daniel M Gordon; M Gross; Bruce T Wellde; W Leitner; Urszula Krzych; I Schneider; Robert A Wirtz; Roberta L Richards; A Trofa; T Hall; J C Sadoff; P Boerger; Carl R Alving; D R Sylvester; T G Porter; W Ripley Ballou
Safety, immunogenicity, and efficacy of Plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes.
The Journal of infectious diseases 1996;174(2):361-6.
1996: Daniel M Gordon; Patrick Duffy; Donald Heppner; Jeffrey A Lyon; J S Williams; D Scheumann; L Farley; D Stacey; J D Haynes; J C Sadoff; W Ripley Ballou
Phase I safety and immunogenicity testing of clinical lots of the synthetic Plasmodium falciparum vaccine SPf66 produced under good manufacturing procedure conditions in the United States.
The American journal of tropical medicine and hygiene 1996;55(1):63-8.
1995: Daniel M Gordon; T W McGovern; Urszula Krzych; J C Cohen; I Schneider; R LaChance; Donald Heppner; G Yuan; M Hollingdale; Moncef Slaoui
Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine.
The Journal of infectious diseases 1995;171(6):1576-85.
1995: W Ripley Ballou; J Blood; T Chongsuphajaissidhi; Daniel M Gordon; Donald Heppner; Dennis E Kyle; Christine Luxemburger; François Nosten; J C Sadoff; Pratap Singhasivanon
Field trials of an asexual blood stage malaria vaccine: studies of the synthetic peptide polymer SPf66 in Thailand and the analytic plan for a phase IIb efficacy study.
Parasitology 1995;110 Suppl():S25-36.
1994: R A Kuschner; Donald Heppner; S L Andersen; Bruce T Wellde; T Hall; I Schneider; W Ripley Ballou; G Foulds; J C Sadoff; BG Schuster
Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum.
Lancet 1994;343(8910):1396-7.
1993: Donald Heppner; A J Magill; Robert A Gasser; Charles N Oster
The threat of infectious diseases in Somalia.
The New England journal of medicine 1993;328(14):1061-8.