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Joseph Coyle

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Yan Li; Loredano Pollegioni; Silvia Sacchi; Alo C Basu; Joseph T Coyle; Vadim Y Bolshakov
Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.
Michael A Benneyworth; Joseph T Coyle
Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function.
Darrick T Balu; Joseph T Coyle
Neuronal D-serine regulates dendritic architecture in the somatosensory cortex.

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All Publications

2013: Yan Li; Loredano Pollegioni; Silvia Sacchi; Alo C Basu; Joseph T Coyle; Vadim Y Bolshakov
Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.
Nature communications 2013;4():1760.
2012: Michael A Benneyworth; Joseph T Coyle
Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(11):2496-504.
2012: Darrick T Balu; Joseph T Coyle
Neuronal D-serine regulates dendritic architecture in the somatosensory cortex.
Neuroscience letters 2012;517(2):77-81.
2012: Joseph T Coyle
Changes in JAMA and the Archives of General Psychiatry: what they mean for readers and authors.
Archives of general psychiatry 2012;69(5):447-8.
2012: Michael A Benneyworth; Vadim Y Bolshakov; Alo C Basu; Yan Li; Joseph T Coyle
Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons.
Cellular and molecular neurobiology 2012;32(4):613-24.
2012: Darrick T Balu; Alo C Basu; Angela M Cacace; John P Corradi; Joseph T Coyle
The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex.
Neurobiology of disease 2012;45(2):671-82.
2012: Joseph T Coyle; Darrick Balu; Alo Basu; Michael Benneyworth; Glenn Konopaske
Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.
Handbook of experimental pharmacology 2012;(213):267-95.
2012: Richard Bergeron; Joseph T Coyle
NAAG, NMDA receptor and psychosis.
Current medicinal chemistry 2012;19(9):1360-4.
2011: Darrick T Balu; Joseph T Coyle
Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction.
Brain research 2011;1392():1-7.
2011: L M DeVito; D T Balu; B R Kanter; C Lykken; Alo C Basu; Joseph T Coyle; H Eichenbaum
Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology.
Genes, brain, and behavior 2011;10(2):210-22.
2011: Michael A Benneyworth; Alexander S Roseman; Alo C Basu; Joseph T Coyle
Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers.
Neuroscience letters 2011;488(3):267-71.
2011: Darrick T Balu; Joseph T Coyle
Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.
Neuroscience and biobehavioral reviews 2011;35(3):848-70.
2011: Michael A Benneyworth; Alo C Basu; Joseph T Coyle
Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function.
Psychopharmacology 2011;213(1):143-53.
2010: Asif K Mustafa; Abdullah Shafique Ahmad; Emil Zeynalov; Sadia K Gazi; Gautam Sikka; Jeffrey T Ehmsen; Roxanne K Barrow; Joseph T Coyle; Solomon H Snyder; Sylvain Dore
Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(4):1413-6.
2010: Joseph T Coyle; Darrick Balu; Michael Benneyworth; Alo Basu; Alexander Roseman
Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.
Dialogues in clinical neuroscience 2010;12(3):359-82.
2009: Joseph T Coyle
MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):2975-6.
2007: Amy Lawson-Yuen; Daniel Liu; Liqun Han; Zhichun I Jiang; Guochuan Tsai; Alo C Basu; Jonathan Picker; Jiamin Feng; Joseph T Coyle
Ube3a mRNA and protein expression are not decreased in Mecp2R168X mutant mice.
Brain research 2007;1180():1-6.
2007: Liqun Han; Dona Lee Wong; Guochuan Tsai; Zhichun Jiang; Joseph T Coyle
Promoter analysis of human glutamate carboxypeptidase II.
Brain research 2007;1170():1-12.
2007: Joseph T Coyle; Hugo Geerts; Karin Sorra; Joan Amatniek
Beyond in vitro data: a review of in vivo evidence regarding the allosteric potentiating effect of galantamine on nicotinic acetylcholine receptors in Alzheimer's neuropathology.
Journal of Alzheimer's disease : JAD 2007;11(4):491-507.
2007: Joseph T Coyle
What can a clock mutation in mice tell us about bipolar disorder?
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6097-8.
2007: Mark A Frye; Guochuan Tsai; Teresa Huggins; Joseph T Coyle; Robert M Post
Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
Biological psychiatry 2007;61(2):162-6.
2007: Richard Bergeron; Yukio Imamura; John V Frangioni; Robert W Greene; Joseph T Coyle
Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus.
Journal of neurochemistry 2007;100(2):346-57.
2006: Joseph T Coyle
Glial metabolites of tryptophan and excitotoxicity: coming unglued.
Experimental neurology 2006;197(1):4-7.
2005: Marzia Martina; Marie-Eve B-Turcotte; Samantha Halman; Guochuan Tsai; Mario Tiberi; Joseph T Coyle; Richard Bergeron
Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice.
The Journal of physiology 2005;563(Pt 3):777-93.
2005: Deborah A Yurgelun-Todd; Joseph T Coyle; Staci A Gruber; Perry F Renshaw; Marisa M Silveri; Edward Amico; Bruce Cohen; Donald C Goff
Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine.
Psychiatry research 2005;138(1):23-31.
2005: Richard Bergeron; Joseph T Coyle; Guochuan Tsai; Robert W Greene
NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(1):7-16.
2004: Joseph T Coyle
The GABA-glutamate connection in schizophrenia: which is the proximate cause?
Biochemical pharmacology 2004;68(8):1507-14.
2004: Joseph T Coyle; Guochuan Tsai
The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia.
Psychopharmacology 2004;174(1):32-8.
2004: Guochuan Tsai; Rebecca J Ralph-Williams; Marzia Martina; Richard Bergeron; Joanne Berger-Sweeney; Kevin S Dunham; Zhichun Jiang; S Barak Caine; Joseph T Coyle
Gene knockout of glycine transporter 1: characterization of the behavioral phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8485-90.
2004: Joseph T Coyle; Guochuan Tsai
NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia.
International review of neurobiology 2004;59():491-515.
2003: Guochuan Tsai; K S Dunham; U Drager; A Grier; C Anderson; J Collura; Joseph T Coyle
Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants.
Synapse (New York, N.Y.) 2003;50(4):285-92.
2003: Joseph T Coyle; Guochuan Tsai; Donald Goff
Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia.
Annals of the New York Academy of Sciences 2003;1003():318-27.
2003: Cecilia Flores; Joseph T Coyle
Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(7):1227-34.
2003: Joseph T Coyle
Use it or lose it--do effortful mental activities protect against dementia?
The New England journal of medicine 2003;348(25):2489-90.
2002: Joseph T Coyle; Guochuan Tsai; Donald C Goff
Ionotropic glutamate receptors as therapeutic targets in schizophrenia.
Current drug targets. CNS and neurological disorders 2002;1(2):183-9.
2002: Guochuan Tsai; Joseph T Coyle
Glutamatergic mechanisms in schizophrenia.
Annual review of pharmacology and toxicology 2002;42():165-79.
2002: Jean A Frazier; Robert Doyle; Sufen Chiu; Joseph T Coyle
Treating a child with Asperger's disorder and comorbid bipolar disorder.
The American journal of psychiatry 2002;159(1):13-21.
2002: Michael L Leski; Linda C Hassinger; Stacey L Valentine; Jesse D Baer; Joseph T Coyle
L-type calcium channels reduce ROS generation in cerebellar granule cells following kainate exposure.
Synapse (New York, N.Y.) 2002;43(1):30-41.
2000: R Greene; R Bergeron; R McCarley; Joseph T Coyle; H Grunze
Short-term and long-term effects of N-methyl-D-aspartate receptor hypofunction.
Archives of general psychiatry 2000;57(12):1180-1; author reply 1182-3.
2000: Michael L Leski; Stacey L Valentine; J D Baer; Joseph T Coyle
Insulin-like growth factor I prevents the development of sensitivity to kainate neurotoxicity in cerebellar granule cells.
Journal of neurochemistry 2000;75(4):1548-56.
2000: JC Leveque; Wendy Macías; Anjali Rajadhyaksha; Richard R Carlson; Amy K Barczak; S Kang; X M Li; Joseph T Coyle; Richard Huganir; Stephan Heckers; Christine Konradi
Intracellular modulation of NMDA receptor function by antipsychotic drugs.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(11):4011-20.
2000: Tuan V Nguyen; Anna-Liisa Brownell; Y C Iris Chen; Eli Livni; Joseph T Coyle; Bruce R Rosen; Friedrich M Cavagna; Bruce G Jenkins
Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET.
Synapse (New York, N.Y.) 2000;36(1):57-65.
2000: Joseph T Coyle; Robert Schwarcz
Mind glue: implications of glial cell biology for psychiatry.
Archives of general psychiatry 2000;57(1):90-3.
1999: Urs V Berger; Ruth Luthi-Carter; LA Passani; S Elkabes; I Black; Christine Konradi; Joseph T Coyle
Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system.
The Journal of comparative neurology 1999;415(1):52-64.
1999: Guochuan Tsai; P Yang; L C Chung; I C Tsai; C W Tsai; Joseph T Coyle
D-serine added to clozapine for the treatment of schizophrenia.
The American journal of psychiatry 1999;156(11):1822-5.
1999: Michael L Leski; Stacey L Valentine; Joseph T Coyle
L-type voltage-gated calcium channels modulate kainic acid neurotoxicity in cerebellar granule cells.
Brain research 1999;828(1-2):27-40.
1999: Guochuan Tsai; William E Falk; Jeanette Gunther; Joseph T Coyle
Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment.
The American journal of psychiatry 1999;156(3):467-9.
1999: D C Goff; G Tsai; J Levitt; E Amico; D Manoach; David Schoenfeld; D L Hayden; R McCarley; Joseph T Coyle
A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia.
Archives of general psychiatry 1999;56(1):21-7.
1999: HS Speno; Ruth Luthi-Carter; W L Macias; S L Valentine; A R Joshi; Joseph T Coyle
Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II.
Molecular pharmacology 1999;55(1):179-85.
1998: Richard Bergeron; T M Meyer; Joseph T Coyle; Robert W Greene
Modulation of N-methyl-D-aspartate receptor function by glycine transport.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15730-4.
1998: Guochuan Tsai; Pinchen Yang; L C Chung; Nicholas Lange; Joseph T Coyle
D-serine added to antipsychotics for the treatment of schizophrenia.
Biological psychiatry 1998;44(11):1081-9.
1998: Guochuan Tsai; Daniel P van Kammen; S Chen; ME Kelley; A Grier; Joseph T Coyle
Glutamatergic neurotransmission involves structural and clinical deficits of schizophrenia.
Biological psychiatry 1998;44(8):667-74.
1998: Guochuan Tsai; Donald C Goff; R W Chang; J Flood; Lee Baer; Joseph T Coyle
Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia.
The American journal of psychiatry 1998;155(9):1207-13.
1998: Charles H Halsted; EH Ling; Ruth Luthi-Carter; Jesus A Villanueva; J M Gardner; Joseph T Coyle
Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II.
The Journal of biological chemistry 1998;273(32):20417-24.
1998: Ruth Luthi-Carter; Amy K Barczak; HS Speno; Joseph T Coyle
Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase).
The Journal of pharmacology and experimental therapeutics 1998;286(2):1020-5.
1998: P J Schwartz; Joseph T Coyle
Effects of overexpression of the cytoplasmic copper-zinc superoxide dismutase on the survival of neurons in vitro.
Synapse (New York, N.Y.) 1998;29(3):206-12.
1998: Ruth Luthi-Carter; Amy K Barczak; HS Speno; Joseph T Coyle
Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II.
Brain research 1998;795(1-2):341-8.
1998: Guochuan Tsai; P Ragan; R Chang; S Chen; V M Linnoila; Joseph T Coyle
Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal.
The American journal of psychiatry 1998;155(6):726-32.
1998: LA Passani; S Elkabes; Joseph T Coyle
Evidence for the presence of N-acetylaspartylglutamate in cultured oligodendrocytes and LPS activated microglia.
Brain research 1998;794(1):143-5.
1998: P J Schwartz; A Reaume; R Scott; Joseph T Coyle
Effects of over- and under-expression of Cu,Zn-superoxide dismutase on the toxicity of glutamate analogs in transgenic mouse striatum.
Brain research 1998;789(1):32-9.
1998: Ruth Luthi-Carter; Urs V Berger; Amy K Barczak; M Enna; Joseph T Coyle
Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3215-20.
1998: G Tsai; Joseph T Coyle
The role of glutamatergic neurotransmission in the pathophysiology of alcoholism.
Annual review of medicine 1998;49():173-84.
1997: Lianna R Orlando; Ruth Luthi-Carter; David G Standaert; Joseph T Coyle; John B Penney; Anne B Young
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo.
Neuroscience letters 1997;236(2):91-4.
1997: LA Passani; Jean-Paul Vonsattel; Joseph T Coyle
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease.
Brain research 1997;772(1-2):9-22.
1997: LA Passani; Jean-Paul Vonsattel; R E Carter; Joseph T Coyle
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1997;31(2):97-118.
1997: Joseph T Coyle
The nagging question of the function of N-acetylaspartylglutamate.
Neurobiology of disease 1997;4(3-4):231-8.
1996: N A Simonian; R L Getz; J C Leveque; Christine Konradi; Joseph T Coyle
Kainic acid induces apoptosis in neurons.
Neuroscience 1996;75(4):1047-55.
1996: N A Simonian; R L Getz; J C Leveque; Christine Konradi; Joseph T Coyle
Kainate induces apoptosis in neurons.
Neuroscience 1996;74(3):675-83.
1996: NG Ranen; C E Peyser; Joseph T Coyle; FW Bylsma; M Sherr; L Day; MARSHAL FOLSTEIN; Jason Brandt; Christopher A Ross; Susan E Folstein
A controlled trial of idebenone in Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society 1996;11(5):549-54.
1996: R E Carter; A R Feldman; Joseph T Coyle
Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):749-53.
1996: N A Simonian; Joseph T Coyle
Oxidative stress in neurodegenerative diseases.
Annual review of pharmacology and toxicology 1996;36():83-106.
1995: C E Peyser; MARSHAL FOLSTEIN; G A Chase; S Starkstein; Jason Brandt; J R Cockrell; FW Bylsma; Joseph T Coyle; Paul R McHugh; Susan E Folstein
Trial of d-alpha-tocopherol in Huntington's disease.
The American journal of psychiatry 1995;152(12):1771-5.
1995: Guochuan Tsai; LA Passani; Barbara Slusher; R Carter; Lee Baer; J E Kleinman; Joseph T Coyle
Abnormal excitatory neurotransmitter metabolism in schizophrenic brains.
Archives of general psychiatry 1995;52(10):829-36.
1995: Joseph T Coyle
Food for thought.
Nature medicine 1995;1(10):1006-7.
1995: Lee Baer; P Cukor; Michael A Jenike; Leslie Leahy; J O'Laughlen; Joseph T Coyle
Pilot studies of telemedicine for patients with obsessive-compulsive disorder.
The American journal of psychiatry 1995;152(9):1383-5.
1995: P J Schwartz; Urs V Berger; Joseph T Coyle
Mice transgenic for copper/zinc superoxide dismutase exhibit increased markers of biogenic amine function.
Journal of neurochemistry 1995;65(2):660-9.
1995: Lee Baer; D G Jacobs; P Cukor; J O'Laughlen; Joseph T Coyle; Kathryn M Magruder
Automated telephone screening survey for depression.
JAMA : the journal of the American Medical Association 1995;273(24):1943-4.
1995: Guochuan Tsai; David Gastfriend; Joseph T Coyle
The glutamatergic basis of human alcoholism.
The American journal of psychiatry 1995;152(3):332-40.
1995: Urs V Berger; R E Carter; Joseph T Coyle
The immunocytochemical localization of N-acetylaspartyl glutamate, its hydrolysing enzyme NAALADase, and the NMDAR-1 receptor at a vertebrate neuromuscular junction.
Neuroscience 1995;64(4):847-50.
1995: Urs V Berger; R E Carter; M McKee; Joseph T Coyle
N-acetylated alpha-linked acidic dipeptidase is expressed by non-myelinating Schwann cells in the peripheral nervous system.
Journal of neurocytology 1995;24(2):99-109.
1994: C A Kitt; C Höhmann; Joseph T Coyle; Donald L Price
Cholinergic innervation of mouse forebrain structures.
The Journal of comparative neurology 1994;341(1):117-29.
1994: James J Vornov; R C Tasker; Joseph T Coyle
Delayed protection by MK-801 and tetrodotoxin in a rat organotypic hippocampal culture model of ischemia.
Stroke; a journal of cerebral circulation 1994;25(2):457-64; discussion 464-5.
1993: Guochuan Tsai; L C Cork; Barbara Slusher; Donald L Price; Joseph T Coyle
Abnormal acidic amino acids and N-acetylaspartylglutamate in hereditary canine motoneuron disease.
Brain research 1993;629(2):305-9.
1993: Joseph T Coyle; P Puttfarcken
Oxidative stress, glutamate, and neurodegenerative disorders.
Science (New York, N.Y.) 1993;262(5134):689-95.
1993: P S Puttfarcken; R L Getz; Joseph T Coyle
Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells.
Brain research 1993;624(1-2):223-32.
1993: Guochuan Tsai; Barbara Slusher; L Sim; Joseph T Coyle
Immunocytochemical distribution of N-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways.
Journal of chemical neuroanatomy 1993;6(5):277-92.
1993: P S Puttfarcken; J S Handen; D T Montgomery; Joseph T Coyle; Linda L Werling
N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices.
The Journal of pharmacology and experimental therapeutics 1993;266(2):796-803.
1992: R C Tasker; Joseph T Coyle; James J Vornov
The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(11):4298-308.
1992: J L Meyerhoff; R E Carter; D L Yourick; Barbara Slusher; Joseph T Coyle
Genetically epilepsy-prone rats have increased brain regional activity of an enzyme which liberates glutamate from N-acetyl-aspartyl-glutamate.
Brain research 1992;593(1):140-3.
1992: P S Puttfarcken; W E Lyons; Joseph T Coyle
Dissociation of nitric oxide generation and kainate-mediated neuronal degeneration in primary cultures of rat cerebellar granule cells.
Neuropharmacology 1992;31(6):565-75.
1992: Barbara Slusher; Guochuan Tsai; G Yoo; Joseph T Coyle
Immunocytochemical localization of the N-acetyl-aspartyl-glutamate (NAAG) hydrolyzing enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase).
The Journal of comparative neurology 1992;315(2):217-29.
1992: J L Meyerhoff; Michael B Robinson; K J Koller; M A Bixler; Joseph T Coyle
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase.
Epilepsy research. Supplement 1992;8():297-305.
1992: J L Meyerhoff; R E Carter; D L Yourick; Barbara Slusher; Joseph T Coyle
Activity of a NAAG-hydrolyzing enzyme in brain may affect seizure susceptibility in genetically epilepsy-prone rats.
Epilepsy research. Supplement 1992;9():163-72.
1991: James J Vornov; R C Tasker; Joseph T Coyle
Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures.
Experimental neurology 1991;114(1):11-22.
1991: Joseph T Coyle; T H Murphy; P S Puttfarcken; E W Lyons; J J Vornov
The non-excitatory mechanisms of glutamate induced neurotoxicity.
Epilepsy research 1991;10(1):41-8.
1991: Guochuan Tsai; B Stauch-Slusher; L Sim; J C Hedreen; Jeffrey rothstein; Ralph W Kuncl; Joseph T Coyle
Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS.
Brain research 1991;556(1):151-6.
1991: George T Capone; C Bendotti; M L Oster-Granite; Joseph T Coyle
Developmental expression of the gene encoding growth-associated protein 43 (Gap43) in the brains of normal and aneuploid mice.
Journal of neuroscience research 1991;29(4):449-60.
1991: Jeffrey rothstein; Ralph W Kuncl; Vinay Chaudhry; Lora Clawson; David R Cornblath; Joseph T Coyle; Daniel B Drachman
Excitatory amino acids in amyotrophic lateral sclerosis: an update.
Annals of neurology 1991;30(2):224-5.
1991: James J Vornov; Joseph T Coyle
Enhancement of NMDA receptor-mediated neurotoxicity in the hippocampal slice by depolarization and ischemia.
Brain research 1991;555(1):99-106.
1991: K Yamada; Mario Saltarelli; Joseph T Coyle
[3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine.
European journal of pharmacology 1991;195(3):395-7.
1991: P Corsi; Joseph T Coyle
Nerve growth factor corrects developmental impairments of basal forebrain cholinergic neurons in the trisomy 16 mouse.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1793-7.
1991: C F Höhmann; L Wilson; Joseph T Coyle
Efferent and afferent connections of mouse sensory-motor cortex following cholinergic deafferentation at birth.
Cerebral cortex (New York, N.Y. : 1991) 1991;1(2):158-72.
1991: C F Höhmann; K K Kwiterovich; M L Oster-Granite; Joseph T Coyle
Newborn basal forebrain lesions disrupt cortical cytodifferentiation as visualized by rapid Golgi staining.
Cerebral cortex (New York, N.Y. : 1991) 1991;1(2):143-57.
1991: T H Murphy; M J De Long; Joseph T Coyle
Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress.
Journal of neurochemistry 1991;56(3):990-5.
1991: James J Vornov; Joseph T Coyle
Glutamate neurotoxicity and the inhibition of protein synthesis in the hippocampal slice.
Journal of neurochemistry 1991;56(3):996-1006.
1991: K Yamada; Mario Saltarelli; Joseph T Coyle
Effects of calmodulin antagonists on sodium-dependent high-affinity choline uptake.
Brain research 1991;542(1):132-4.
1991: P T Joshi; J A Capozzoli; Joseph T Coyle
Neuroleptic malignant syndrome: life-threatening complication of neuroleptic treatment in adolescents with affective disorder.
Pediatrics 1991;87(2):235-9.
1991: K Kato; P S Puttfarcken; W E Lyons; Joseph T Coyle
Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures.
The Journal of pharmacology and experimental therapeutics 1991;256(1):402-11.
1991: Joseph T Coyle; M L Oster-Granite; Roger H Reeves; Christine F Hohmann; P Corsi; John D Gearhart
Down syndrome and the trisomy 16 mouse: impact of gene imbalance on brain development and aging.
Research publications - Association for Research in Nervous and Mental Disease 1991;69():85-99.
1991: M L Simmons; Carmelita G Frondoza; Joseph T Coyle
Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies.
Neuroscience 1991;45(1):37-45.
1990: Barbara Slusher; Michael B Robinson; Guochuan Tsai; M L Simmons; S S Richards; Joseph T Coyle
Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization.
The Journal of biological chemistry 1990;265(34):21297-301.
1990: Jeffrey rothstein; Guochuan Tsai; Ralph W Kuncl; Lora Clawson; David R Cornblath; Daniel B Drachman; A Pestronk; B L Stauch; Joseph T Coyle
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis.
Annals of neurology 1990;28(1):18-25.
1990: Guochuan Tsai; B L Stauch; James J Vornov; J K Deshpande; Joseph T Coyle
Selective release of N-acetylaspartylglutamate from rat optic nerve terminals in vivo.
Brain research 1990;518(1-2):313-6.
1990: T H Murphy; Ronald Schnaar; Joseph T Coyle
Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(6):1624-33.
1990: M Miyamoto; Joseph T Coyle
Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins.
Experimental neurology 1990;108(1):38-45.
1990: Gianluigi Forloni; Christine F Hohmann; Joseph T Coyle
Developmental expression of somatostatin in mouse brain. I. Immunocytochemical studies.
Brain research. Developmental brain research 1990;53(1):6-25.
1990: C Bendotti; Christine F Hohmann; Gianluigi Forloni; Roger H Reeves; Joseph T Coyle; M L Oster-Granite
Developmental expression of somatostatin in mouse brain. II. In situ hybridization.
Brain research. Developmental brain research 1990;53(1):26-39.
1990: Maria T Caserta; P Corsi; M L Oster-Granite; Joseph T Coyle
Increased number of somatostatin-immunoreactive neurons in primary cultures of trisomy 16 mouse neocortex.
Brain research. Molecular brain research 1990;7(3):269-72.
1990: P T Joshi; J A Capozzoli; Joseph T Coyle
The Johns Hopkins Depression Scale: normative data and validation in child psychiatry patients.
Journal of the American Academy of Child and Adolescent Psychiatry 1990;29(2):283-8.
1990: P R Lowenstein; Jeffrey N. Joyce; Joseph T Coyle; J F Marshall
Striosomal organization of cholinergic and dopaminergic uptake sites and cholinergic M1 receptors in the adult human striatum: a quantitative receptor autoradiographic study.
Brain research 1990;510(1):122-6.
1990: Mario Saltarelli; K Yamada; Joseph T Coyle
Phospholipase A2 and 3H-hemicholinium-3 binding sites in rat brain: a potential second-messenger role for fatty acids in the regulation of high-affinity choline uptake.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(1):62-72.
1990: J E Sweeney; E S Bachman; Joseph T Coyle
Effects of different doses of galanthamine, a long-acting acetylcholinesterase inhibitor, on memory in mice.
Psychopharmacology 1990;102(2):191-200.
1990: C F Höhmann; George T Capone; M L Oster-Granite; Joseph T Coyle
Transplantation of brain tissue from murine trisomy 16 into euploid hosts: effects of gene imbalance on brain development.
Progress in brain research 1990;82():203-14.
1989: J L Meyerhoff; Michael B Robinson; M A Bixler; S S Richards; Joseph T Coyle
Seizures decrease regional enzymatic hydrolysis of N-acetyl-aspartylglutamate in rat brain.
Brain research 1989;505(1):130-4.
1989: P R Lowenstein; P A Slesinger; Harvey S Singer; Lary Walker; M F Casanova; L S Raskin; Donald L Price; Joseph T Coyle
Compartment-specific changes in the density of choline and dopamine uptake sites and muscarinic and dopaminergic receptors during the development of the baboon striatum: a quantitative receptor autoradiographic study.
The Journal of comparative neurology 1989;288(3):428-46.
1989: M Miyamoto; T H Murphy; Ronald Schnaar; Joseph T Coyle
Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.
The Journal of pharmacology and experimental therapeutics 1989;250(3):1132-40.
1989: J E Sweeney; P S Puttfarcken; Joseph T Coyle
Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice.
Pharmacology, biochemistry, and behavior 1989;34(1):129-37.
1989: Gianluigi Forloni; K Blake; Christine F Hohmann; Joseph T Coyle
The postnatal expression of acetylcholinesterase in somatostatin-positive cells of mouse hippocampus.
Brain research. Developmental brain research 1989;48(1):73-85.
1989: K Yamada; Mario Saltarelli; Joseph T Coyle
Specificity of the activation of [3H]hemicholinium-3 binding by phospholipase A2.
The Journal of pharmacology and experimental therapeutics 1989;249(3):836-42.
1989: T H Murphy; M Miyamoto; Antonio Sastre; Ronald Schnaar; Joseph T Coyle
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress.
Neuron 1989;2(6):1547-58.
1989: B L Stauch; Michael B Robinson; Gianluigi Forloni; Guochuan Tsai; Joseph T Coyle
The effects of N-acetylated alpha-linked acidic dipeptidase (NAALADase) inhibitors on [3H]NAAG catabolism in vivo.
Neuroscience letters 1989;100(1-3):295-300.
1989: J E Sweeney; C F Höhmann; M L Oster-Granite; Joseph T Coyle
Neurogenesis of the basal forebrain in euploid and trisomy 16 mice: an animal model for developmental disorders in Down syndrome.
Neuroscience 1989;31(2):413-25.
1988: Guochuan Tsai; Gianluigi Forloni; Michael B Robinson; B L Stauch; Joseph T Coyle
Calcium-dependent evoked release of N-[3H]acetylaspartylglutamate from the optic pathway.
Journal of neurochemistry 1988;51(6):1956-9.
1988: Mario Saltarelli; J Lopez; P R Lowenstein; Joseph T Coyle
The role of calcium in the regulation of [3H]hemicholinium-3 binding sites in rat brain.
Neuropharmacology 1988;27(12):1301-8.
1988: B F O'Hara; C Bendotti; Roger H Reeves; M L Oster-Granite; Joseph T Coyle; John D Gearhart
Genetic mapping and analysis of somatostatin expression in Snell dwarf mice.
Brain research 1988;464(4):283-92.
1988: K Yamada; Mario Saltarelli; Joseph T Coyle
Involvement of phospholipase A2 in the regulation of [3H]hemicholinium-3 binding.
Biochemical pharmacology 1988;37(22):4367-73.
1988: T H Murphy; Ronald Schnaar; Joseph T Coyle; Antonio Sastre
Glutamate cytotoxicity in a neuronal cell line is blocked by membrane depolarization.
Brain research 1988;460(1):155-60.
1988: J E Sweeney; C F Höhmann; Timothy H Moran; Joseph T Coyle
A long-acting cholinesterase inhibitor reverses spatial memory deficits in mice.
Pharmacology, biochemistry, and behavior 1988;31(1):141-7.
1988: P T Joshi; J A Capozzoli; Joseph T Coyle
Use of a quiet room on an inpatient unit.
Journal of the American Academy of Child and Adolescent Psychiatry 1988;27(5):642-4.
1988: Christine F Hohmann; R Hamon; Mark L Batshaw; Joseph T Coyle
Transient postnatal elevation of serotonin levels in mouse neocortex.
Brain research 1988;471(1):163-6.
1988: Christine F Hohmann; A R Brooks; Joseph T Coyle
Neonatal lesions of the basal forebrain cholinergic neurons result in abnormal cortical development.
Brain research 1988;470(2):253-64.
1988: P A Slesinger; P R Lowenstein; Harvey S Singer; Lary Walker; M F Casanova; Donald L Price; Joseph T Coyle
Development of beta 1 and beta 2 adrenergic receptors in baboon brain: an autoradiographic study using [125I]iodocyanopindolol.
The Journal of comparative neurology 1988;273(3):318-29.
1988: Randy D Blakely; Michael B Robinson; Angela S Guarda; Joseph T Coyle
A re-examination of the interaction of N-acetyl-L-aspartyl-L-glutamate with a subpopulation of rat brain membrane L-[3H]glutamate binding sites.
European journal of pharmacology 1988;151(3):419-26.
1988: C F Höhmann; Joseph T Coyle
Long-term effects of basal forebrain lesions on cholinergic, noradrenergic and serotonergic markers in mouse neocortex.
Brain research bulletin 1988;21(1):13-20.
1988: Angela S Guarda; Michael B Robinson; L Ory-Lavollée; Gianluigi Forloni; Randy D Blakely; Joseph T Coyle
Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay.
Brain research 1988;427(3):223-31.
1988: K Yamada; Mario Saltarelli; Joseph T Coyle
Solubilization and characterization of a [3H]hemicholinium-3 binding site in rat brain.
Journal of neurochemistry 1988;50(6):1759-64.
1988: C Bendotti; Gianluigi Forloni; R A Morgan; B F O'Hara; M L Oster-Granite; Roger H Reeves; John D Gearhart; Joseph T Coyle
Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3628-32.
1988: Mark L Batshaw; S L Hyman; Joseph T Coyle; Michael B Robinson; Ijaz Qureshi; E D Mellits; SA Quaskey
Effect of sodium benzoate and sodium phenylacetate on brain serotonin turnover in the ornithine transcarbamylase-deficient sparse-fur mouse.
Pediatric research 1988;23(4):368-74.
1988: Randy D Blakely; Michael B Robinson; R C Thompson; Joseph T Coyle
Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate: subcellular and regional distribution, ontogeny, and the effect of lesions on N-acetylated-alpha-linked acidic dipeptidase activity.
Journal of neurochemistry 1988;50(4):1200-9.
1988: T H Murphy; A T Malouf; Antonio Sastre; Ronald Schnaar; Joseph T Coyle
Calcium-dependent glutamate cytotoxicity in a neuronal cell line.
Brain research 1988;444(2):325-32.
1988: P T Joshi; J A Capozzoli; Joseph T Coyle
Low-dose neuroleptic therapy for children with childhood-onset pervasive developmental disorder.
The American journal of psychiatry 1988;145(3):335-8.
1987: G F Hohmann; Gary L Wenk; P Lowenstein; M E Brown; Joseph T Coyle
Age-related recurrence of basal forebrain lesion-induced cholinergic deficits.
Neuroscience letters 1987;82(3):253-9.
1987: Michael B Robinson; Joseph T Coyle
Glutamate and related acidic excitatory neurotransmitters: from basic science to clinical application.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1987;1(6):446-55.
1987: Michael B Robinson; Randy D Blakely; R Couto; Joseph T Coyle
Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain.
The Journal of biological chemistry 1987;262(30):14498-506.
1987: Roger H Reeves; Nikolaos K Robakis; M L Oster-Granite; Henryk M Wisniewski; Joseph T Coyle; John D Gearhart
Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man.
Brain research 1987;388(3):215-21.
1987: D J Braitman; Joseph T Coyle
Inhibition of [3H]kainic acid receptor binding by divalent cations correlates with ion affinity for the calcium channel.
Neuropharmacology 1987;26(9):1247-51.
1987: Randy D Blakely; L Ory-Lavollée; Joseph T Coyle
Specific alterations in the levels of N-acetyl-aspartyl-glutamate in the nervous system of the dystrophic mouse.
Neuroscience letters 1987;79(1-2):223-8.
1987: P R Lowenstein; P A Slesinger; Harvey S Singer; Lary Walker; M F Casanova; Donald L Price; Joseph T Coyle
An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system.
Brain research 1987;431(2):291-7.
1987: R Zaczek; S Arlis; A Markl; T Murphy; H Drucker; Joseph T Coyle
Characteristics of chloride-dependent incorporation of glutamate into brain membranes argue against a receptor binding site.
Neuropharmacology 1987;26(4):281-7.
1987: Mario Saltarelli; P R Lowenstein; Joseph T Coyle
Rapid in vitro modulation of [3H]hemicholinium-3 binding sites in rat striatal slices.
European journal of pharmacology 1987;135(1):35-40.
1987: L Ory-Lavollée; Randy D Blakely; Joseph T Coyle
Neurochemical and immunocytochemical studies on the distribution of N-acetyl-aspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues.
Journal of neurochemistry 1987;48(3):895-9.
1987: Randy D Blakely; L Ory-Lavollée; R Grzanna; K J Koller; Joseph T Coyle
Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate.
Brain research 1987;402(2):373-8.
1987: Gianluigi Forloni; R Grzanna; Randy D Blakely; Joseph T Coyle
Co-localization of N-acetyl-aspartyl-glutamate in central cholinergic, noradrenergic, and serotonergic neurons.
Synapse (New York, N.Y.) 1987;1(5):455-60.
1987: John D Gearhart; M L Oster-Granite; Roger H Reeves; Joseph T Coyle
Developmental consequences of autosomal aneuploidy in mammals.
Developmental genetics 1987;8(4):249-65.
1987: Mario Saltarelli; Gianluigi Forloni; M L Oster-Granite; John D Gearhart; Joseph T Coyle
Neurochemical characterization of embryonic brain development in trisomy 19 (Ts19) mice: implications of selective deficits observed for abnormal neural development in aneuploidy.
Developmental genetics 1987;8(4):267-79.
1987: R Zaczek; M Balm; S Arlis; H Drucker; Joseph T Coyle
Quisqualate-sensitive, chloride-dependent transport of glutamate into rat brain synaptosomes.
Journal of neuroscience research 1987;18(3):425-31.
1986: Mark L Batshaw; S L Hyman; E D Mellits; George H Thomas; R DeMuro; Joseph T Coyle
Behavioral and neurotransmitter changes in the urease-infused rat: a model of congenital hyperammonemia.
Pediatric research 1986;20(12):1310-5.
1986: R Zaczek; A Markl; M Balm; Joseph T Coyle
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Journal of neuroscience methods 1986;18(4):351-60.
1986: Randy D Blakely; L Ory-Lavollée; R C Thompson; Joseph T Coyle
Synaptosomal transport of radiolabel from N-acetyl-aspartyl-[3H]glutamate suggests a mechanism of inactivation of an excitatory neuropeptide.
Journal of neurochemistry 1986;47(4):1013-9.
1986: S L Hyman; Joseph T Coyle; J C Parke; C Porter; George H Thomas; W Jankel; Mark L Batshaw
Anorexia and altered serotonin metabolism in a patient with argininosuccinic aciduria.
The Journal of pediatrics 1986;108(5 Pt 1):705-9.
1986: Joseph T Coyle; Randy D Blakely; R Zaczek; K J Koller; M Abreu; L Ory-Lavollée; R Fisher; Jarlath ffrench-Mullen; D O Carpenter
Acidic peptides in brain: do they act at putative glutamatergic synapses?
Advances in experimental medicine and biology 1986;203():375-84.
1985: Jarlath ffrench-Mullen; K Koller; R Zaczek; Joseph T Coyle; N Hori; D O Carpenter
N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(11):3897-900.
1984: A T Malouf; Joseph T Coyle; Ronald Schnaar
Agonists and cations regulate the glutamic acid receptors on intact neuroblastoma hybrid cells.
The Journal of biological chemistry 1984;259(20):12763-8.
1984: A T Malouf; Ronald Schnaar; Joseph T Coyle
Characterization of a glutamic acid neurotransmitter binding site on neuroblastoma hybrid cells.
The Journal of biological chemistry 1984;259(20):12756-62.
1984: K J Koller; R Zaczek; Joseph T Coyle
N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method.
Journal of neurochemistry 1984;43(4):1136-42.
1984: J W Ferkany; R Zaczek; Joseph T Coyle
The mechanism of kainic acid neurotoxicity.
Nature 1984;308(5959):561-2.
1984: J Ferkany; R Zaczek; A Markl; Joseph T Coyle
Glutamate-containing dipeptides enhance specific binding at glutamate receptors and inhibit specific binding at kainate receptors in rat brain.
Neuroscience letters 1984;44(3):281-6.
1983: Joseph T Coyle; J W Ferkany; R Zaczek
Kainic acid: insights from a neurotoxin into the pathophysiology of Huntington's disease.
Neurobehavioral toxicology and teratology 1983;5(6):617-24.
1983: R Zaczek; K Koller; R Cotter; D Heller; Joseph T Coyle
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(4):1116-9.
1982: J W Ferkany; J T Slevin; R Zaczek; Joseph T Coyle
Failure of folic acid derivatives to mimic the actions of kainic acid in brain in vitro or in vivo.
Neurobehavioral toxicology and teratology 1982;4(5):573-9.
1982: J W Ferkany; R Zaczek; Joseph T Coyle
Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors.
Nature 1982;298(5876):757-9.
1978: K Biziere; Joseph T Coyle
Influence of cortico-striatal afferents on striatal kainic acid neurotoxicity.
Neuroscience letters 1978;8(4):303-10.
1977: R Grzanna; J H Morrison; Joseph T Coyle; Mark E Molliver
The immunohistochemical demonstration of noradrenergic neurons in the rat brain: The use of homologous antiserum to dopamine-beta-hydroxylase.
Neuroscience letters 1977;4(3-4):127-34.