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Hongbo Luo

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Physiology

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Yuanfu Xu; Keqiang Ye; Jiaxi Zhou; Yuan Zhou; Haiyan Zhu; Besnik Bajrami; Shannan Cao; Hyunjeong Kwak; Hongmei Li; Peng Liu; Hongbo R Luo
Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate.
Chong Gao; Ha-won Jeong; Hongbo R Luo; Hiro Tatetsu; Daniel G Tenen; Kol Jia Yong; James E Bradner; Todor Dimitrov; Li Chai
Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.
Jiro Sakai; Kulandayan K Subramanian; Keqiang Ye; Jia Zhong; Jun Zhou; Subhanjan Mondal; Besnik Bajrami; Christopher J Chang; Bryan C Dickinson; Hidenori Hattori; Ye-Shih Ho; Yonghui Jia; Jingyu Li; Hongbo R Luo
Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils.

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2013: Yuanfu Xu; Keqiang Ye; Jiaxi Zhou; Yuan Zhou; Haiyan Zhu; Besnik Bajrami; Shannan Cao; Hyunjeong Kwak; Hongmei Li; Peng Liu; Hongbo R Luo
Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):7726-31.
2013: Chong Gao; Ha-won Jeong; Hongbo R Luo; Hiro Tatetsu; Daniel G Tenen; Kol Jia Yong; James E Bradner; Todor Dimitrov; Li Chai
Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.
Blood 2013;121(8):1413-21.
2012: Jiro Sakai; Kulandayan K Subramanian; Keqiang Ye; Jia Zhong; Jun Zhou; Subhanjan Mondal; Besnik Bajrami; Christopher J Chang; Bryan C Dickinson; Hidenori Hattori; Ye-Shih Ho; Yonghui Jia; Jingyu Li; Hongbo R Luo
Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils.
Immunity 2012;37(6):1037-49.
2012: Xia Liu; Hongbo R Luo; Qi Qi; Ge Xiao; Chi-Bun Chan; Xiaolin He; Keqiang Ye
Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression.
Journal of medicinal chemistry 2012;55(19):8524-37.
2012: Hakryul Jo; Qingming Hou; Hengye Man; Subhanjan Mondal; Eiichiro Nagata; Amit Prasad; Alan C Rigby; Kumaran Shanmugasundaram; Alok K Sharma; Shunya Takizawa; Dewar Tan; Alexander O Tejeda; Joe K Tung; Hongbo R Luo
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10581-6.
2012: Long-Jun Wu; M Reza Akhavan Sharif; Amanda Baker; Frederic H Fahey; Edward P Feener; Yonghui Jia; Hongbo R Luo; Gongxiong Wu; David E Clapham
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke.
Nature neuroscience 2012;15(4):565-73.
2012: Subhanjan Mondal; Jiro Sakai; Kulandayan K Subramanian; Besnik Bajrami; Hongbo R Luo
Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion.
Molecular biology of the cell 2012;23(7):1219-30.
2012: Jiayun Lu; Hongbo R Luo; César Nombela-Arrieta; Shin-Young Park; Li Chai; Karrie P Du; Yan Sun; Carl Walkley; Leslie E Silberstein
Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion.
Experimental hematology 2012;40(4):307-17.e3.
2012: Hakryul Jo; Hongbo R Luo
Exploiting effectors of Rac GTPase.
Chemistry & biology 2012;19(2):169-71.
2012: Shunya Takizawa; Eiichiro Nagata; Hongbo R Luo
[Novel neuroprotective agents: a HIF activator and an Akt activator].
Rinshō shinkeigaku = Clinical neurology 2012;52(11):911-2.
2011: Subhanjan Mondal; David A Williams; Saurabh Ghosh-Roy; Chad Harris; Yonghui Jia; Yitang Li; Fabien Loison; Hongbo R Luo
PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(11):5783-94.
2011: Kunyan He; Yonghui Jia; Xia Liu; Yang Liu; Hongbo R Luo; W David Wilson; Chi-Bun Chan; Stephan Anthony France; Keqiang Ye
Identification of a molecular activator for insulin receptor with potent anti-diabetic effects.
The Journal of biological chemistry 2011;286(43):37379-88.
2011: Amit Prasad; Saurabh Ghosh Roy; Jiro Sakai; Solomon H Snyder; Jia Zhong; Catlyn Blanchard; anutosh chakraborty; Supriya K Jain; Yonghui Jia; Yitang Li; Fabien Loison; Subhanjan Mondal; Hongbo R Luo
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.
Nature immunology 2011;12(8):752-60.
2011: Yitang Li; Fabien Loison; Sheng Ding; Yonghui Jia; Paulina Kocjan; Subhanjan Mondal; Amit Prasad; Saurabh Ghosh Roy; Leslie E Silberstein; Hongbo R Luo
Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model.
Blood 2011;117(24):6702-13.
2011: Abel Sanchez-Aguilera; David T Scadden; Kristina Brumme; Adrienne Dorrance; Francesca Ferraro; Chaekyun Kim; Yun-Jung Lee; Cristina Lo Celso; Hongbo R Luo; Subhanjan Mondal; David A Williams
Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(23):9607-12.
2011: Chi Bun Chan; Xia Liu; Sompol Pradoldej; Chunhai Hao; Jie An; Manuel Yepes; Hongbo R Luo; Keqiang Ye
Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(22):8083-92.
2011: Hakryul Jo; Pang-Kuo Lo; Yitang Li; Fabien Loison; Sarah Green; Jake Wang; Leslie E Silberstein; Keqiang Ye; Hexin Chen; Hongbo R Luo
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(16):6486-91.
2010: Carla Carbo; Daniel Duerschmied; Tobias Goerge; Hidenori Hattori; Jiro Sakai; Stephen M Cifuni; Gilbert C White; Magdalena Wodnicka; Hongbo R Luo; Denisa D Wagner
Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.
Journal of leukocyte biology 2010;88(2):313-9.
2010: Hidenori Hattori; Kulandayan K Subramanian; Jiro Sakai; Hongbo R Luo
Reactive oxygen species as signaling molecules in neutrophil chemotaxis.
Communicative & integrative biology 2010;3(3):278-81.
2010: Chi Bun Chan; Xia Liu; Dae Young Jung; John Y Jun; Hongbo R Luo; Jason K Kim; Keqiang Ye
Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.
Diabetes 2010;59(4):883-93.
2010: Hidenori Hattori; Kulandayan K Subramanian; Jiro Sakai; Yonghui Jia; Yitang Li; Timothy F Porter; Fabien Loison; Bara Sarraj; Anongnard Kasorn; Hakryul Jo; Catlyn Blanchard; Dorothy Zirkle; Douglas McDonald; Sung-Yun Pai; Charles N Serhan; Hongbo R Luo
Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3546-51.
2010: Yuanfu Xu; Fabien Loison; Hongbo R Luo
Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kgamma, ROS, and actin.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):2950-5.
2010: Hakryul Jo; Fabien Loison; Hidenori Hattori; Leslie E Silberstein; Hongtao Yu; Hongbo R Luo
Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.
PloS one 2010;5(4):e10318.
2009: Anongnard Kasorn; Pilar Alcaide; Yonghui Jia; Kulandayan K Subramanian; Bara Sarraj; Yitang Li; Fabien Loison; Hidenori Hattori; Leslie E Silberstein; William F Luscinskas; Hongbo R Luo
Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1032-43.
2009: Bara Sarraj; Steffen Massberg; Yitang Li; Anongnard Kasorn; Kulandayan Subramanian; Fabien Loison; Leslie E Silberstein; Ulrich von Andrian; Hongbo R Luo
Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):7190-200.
2009: Yitang Li; Yonghui Jia; Muriel Pichavant; Fabien Loison; Bara Sarraj; Anongnard Kasorn; Jian You; Bryanne E Robson; Dale T Umetsu; Joseph P Mizgerd; Keqiang Ye; Hongbo R Luo
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia.
Blood 2009;113(20):4930-41.
2009: Jiayun Lu; Ha-Won Jeong; Hawon Jeong; Nikki Kong; Youyang Yang; John Carroll; Hongbo R Luo; Leslie E Silberstein; Li Chai
Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.
PloS one 2009;4(5):e5577.
2008: Yonghui Jia; Stéphane Schurmans; Hongbo R Luo
Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate.
Cell cycle (Georgetown, Tex.) 2008;7(18):2803-8.
2008: Hakryul Jo; Yonghui Jia; Kulandayan K Subramanian; Hidenori Hattori; Hongbo R Luo
Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation.
Molecular and cellular biology 2008;28(13):4285-99.
2008: Hongbo R Luo; Fabien Loison
Constitutive neutrophil apoptosis: mechanisms and regulation.
American journal of hematology 2008;83(4):288-95.
2008: Zhixue Liu; Sung-Wuk Jang; Xia Liu; Dongmei Cheng; Junmin Peng; Manuel Yepes; Xiao-Jiang Li; Steve Matthews; Colin Watts; Masahide Asano; Ikuko Hara-Nishimura; Hongbo R Luo; Keqiang Ye
Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase.
Molecular cell 2008;29(6):665-78.
2008: Yonghui Jia; Fabien Loison; Hidenori Hattori; Yitang Li; Christophe Erneux; Shin-Young Park; Chong Gao; Li Chai; Leslie E Silberstein; Stephane Schurmans; Hongbo R Luo
Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4739-44.
2007: Yi Le; Bing-Mei Zhu; Brendan Harley; Shin-Young Park; Takashi Kobayashi; John P Manis; Hongbo R Luo; Akihiko Yoshimura; Lothar Hennighausen; Leslie E Silberstein
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.
Immunity 2007;27(5):811-23.
2007: Yonghui Jia; Kulandayan K Subramanian; Christophe Erneux; Valérie Pouillon; Hidenori Hattori; Hakryul Jo; Jian You; Daocheng Zhu; Stéphane Schurmans; Hongbo R Luo
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils.
Immunity 2007;27(3):453-67.
2007: Yoann Maréchal; Xavier Pesesse; Yonghui Jia; Valérie Pouillon; David Pérez-Morga; Julien Daniel; Shozo Izui; Peter J Cullen; Oberdan Leo; Hongbo R Luo; Christophe Erneux; Stéphane Schurmans
Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):13978-83.
2007: Hidenori Hattori; Xueqing Zhang; Yonghui Jia; Kulandayan K Subramanian; Hakryul Jo; Fabien Loison; Peter E Newburger; Hongbo R Luo
RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells.
Blood 2007;110(2):640-50.
2007: Kulandayan K Subramanian; Yonghui Jia; Daocheng Zhu; Benjamin T Simms; Hakryul Jo; Hidenori Hattori; Jian You; Joseph P Mizgerd; Hongbo R Luo
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions.
Blood 2007;109(9):4028-37.
2007: Yunfei Huang; Bingnan N Kang; Jing Tian; Yi Liu; Hongbo R Luo; Lynda D Hester; Solomon H Snyder
The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(3):449-58.
2006: Daocheng Zhu; Hidenori Hattori; Hakryul Jo; Yonghui Jia; Kulandayan K Subramanian; Fabien Loison; Jian You; Yi Le; Marek Honczarenko; Leslie E Silberstein; Hongbo R Luo
Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14836-41.
2005: Yunfei Huang; Heng-Ye Man; Yoko Sekine-Aizawa; Yefei Han; Krishna R Juluri; Hongbo R Luo; Jaime H Cheah; Charles J Lowenstein; Richard Huganir; Solomon H Snyder
S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors.
Neuron 2005;46(4):533-40.
2005: Eiichiro Nagata; Hongbo R Luo; Adolfo Saiardi; Byoung-Il Bae; Norihiro Suzuki; Solomon H Snyder
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.
The Journal of biological chemistry 2005;280(2):1634-40.
2004: Miho Iijima; Yi Elaine Huang; Hongbo R Luo; Francisca Vazquez; Peter N Devreotes
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis.
The Journal of biological chemistry 2004;279(16):16606-13.
2003: Hongbo R Luo; Hidenori Hattori; Mir Ahamed Hossain; Lynda D Hester; Yunfei Huang; Whaseon L Kwon; Mark Donowitz; Eiichiro Nagata; Solomon H Snyder
Akt as a mediator of cell death.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11712-7.
2003: Hongbo R Luo; Yi Elaine Huang; Jianmeng C Chen; Adolfo Saiardi; Miho Iijima; Keqiang Ye; Yunfei Huang; Eiichiro Nagata; Peter N Devreotes; Solomon H Snyder
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.
Cell 2003;114(5):559-72.
2002: Hongbo R Luo; Adolfo Saiardi; Hongbo Yu; Eiichiro Nagata; Keqiang Ye; Solomon H Snyder
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast.
Biochemistry 2002;41(8):2509-15.
2002: Keqiang Ye; Bahman Aghdasi; Hongbo R Luo; John L Moriarity; Frederick Y Wu; Jenny J Hong; K Joseph Hurt; Sun Sik Bae; Pann-Ghill Suh; Solomon H Snyder
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.
Nature 2002;415(6871):541-4.
2001: Hongbo R Luo; Charles R Dearolf
The JAK/STAT pathway and Drosophila development.
BioEssays : news and reviews in molecular, cellular and developmental biology 2001;23(12):1138-47.
2001: Adolfo Saiardi; Eiichiro Nagata; Hongbo R Luo; Adele M Snowman; Solomon H Snyder
Identification and characterization of a novel inositol hexakisphosphate kinase.
The Journal of biological chemistry 2001;276(42):39179-85.
2001: Hongbo R Luo; Adolfo Saiardi; Eiichiro Nagata; Keqiang Ye; H Yu; T S Jung; Xiaojiang Luo; S Jain; Akira Sawa; Solomon H Snyder
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.
Neuron 2001;31(3):439-51.
2001: Adolfo Saiardi; Eiichiro Nagata; Hongbo R Luo; Akira Sawa; Xiaojiang Luo; Adele M Snowman; Solomon H Snyder
Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2306-11.
2000: Keqiang Ye; K Joseph Hurt; Frederick Y Wu; M Fang; Hongbo R Luo; Jenny J Hong; Seth Blackshaw; Christopher D Ferris; Solomon H Snyder
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.
Cell 2000;103(6):919-30.
2000: MM Lai; Hongbo R Luo; PE Burnett; Jenny J Hong; Solomon H Snyder
The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis.
The Journal of biological chemistry 2000;275(44):34017-20.
1999: Hongbo R Luo; G A Moreau; N Levin; Melissa J Moore
The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes.
RNA (New York, N.Y.) 1999;5(7):893-908.
1999: José L Reyes; E H Gustafson; Hongbo R Luo; M J Moore; Maria M Konarska
The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site.
RNA (New York, N.Y.) 1999;5(2):167-79.
1996: Riqiang Yan; Hongbo R Luo; James E Darnell; Charles R Dearolf
A JAK-STAT pathway regulates wing vein formation in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5842-7.
1995: Hongbo R Luo; W P Hanratty; Charles R Dearolf
An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.
The EMBO journal 1995;14(7):1412-20.