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John Carver

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Phenomena

Living Beings

Cattle

Concepts & Ideas

Anatomy

Crystalline Lens

Genes & Molecular Sequences

Amino Acid Sequence

Procedures

Physiology

Protein Folding

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Network (preview)

Co-Publications
Name
18
Truscott, Roger
17
Lindner, Robyn
13
Aquilina, Andrew
10
Bowie, John
10
Ecroyd, Heath
8
Treweek, Teresa
7
Wilson, Mark
6
Rekas, Agata
5
Easterbrook-Smith, Simon
5
Thorn, David
5
Meehan, Sarah
5
de Jong, Wilfried
5
Wegener, Kate
4
Tyler, Michael
4
Wallace, John

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Publications

TOP 3
Hudson Sean A; Ecroyd Heath; Kee Tak W; Carver John A
The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds.
Hudson Sean A; Ecroyd Heath; Dehle Francis C; Musgrave Ian F; Carver John A
(-)-epigallocatechin-3-gallate (EGCG) maintains kappa-casein in its pre-fibrillar state without redirecting its aggregation pathway.
Ecroyd H; Carver John A
Crystallin proteins and amyloid fibrils.

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All Publications

2009: Hudson Sean A; Ecroyd Heath; Kee Tak W; Carver John A
The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds.
The FEBS journal 2009;276(20):5960-72.
2009: Hudson Sean A; Ecroyd Heath; Dehle Francis C; Musgrave Ian F; Carver John A
(-)-epigallocatechin-3-gallate (EGCG) maintains kappa-casein in its pre-fibrillar state without redirecting its aggregation pathway.
Journal of molecular biology 2009;392(3):689-700.
2009: Ecroyd H; Carver John A
Crystallin proteins and amyloid fibrils.
Cellular and molecular life sciences : CMLS 2009;66(1):62-81.
2008: Morris Amie M; Treweek Teresa M; Aquilina J A; Carver John A; Walker Mark J
Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity.
The FEBS journal 2008;275(23):5885-98.
2008: Ecroyd Heath; Carver John A
Unraveling the mysteries of protein folding and misfolding.
IUBMB life 2008;60(12):769-74.
2008: Ecroyd Heath; Koudelka Tomas; Thorn David C; Williams Danielle M; Devlin Glyn; Hoffmann Peter; Carver John A
Dissociation from the oligomeric state is the rate-limiting step in fibril formation by kappa-casein.
The Journal of biological chemistry 2008;283(14):9012-22.
2008: Thorn David C; Ecroyd Heath; Sunde Margaret; Poon Stephen; Carver John A
Amyloid fibril formation by bovine milk alpha s2-casein occurs under physiological conditions yet is prevented by its natural counterpart, alpha s1-casein.
Biochemistry 2008;47(12):3926-36.
2008: Ecroyd Heath; Carver John A
The effect of small molecules in modulating the chaperone activity of alphaB-crystallin against ordered and disordered protein aggregation.
The FEBS journal 2008;275(5):935-47.
2007: Rekas Agata; Jankova Lucy; Thorn David C; Cappai Roberto; Carver John A
Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species.
The FEBS journal 2007;274(24):6290-304.
2007: Meehan Sarah; Knowles Tuomas P J; Baldwin Andrew J; Smith Jeffrey F; Squires Adam M; Clements Phillip; Treweek Teresa M; Ecroyd Heath; Tartaglia Gian Gaetano; Vendruscolo Michele; Macphee Cait E; Dobson Christopher M; Carver John A
Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.
Journal of molecular biology 2007;372(2):470-84.
2007: Ghahghaei Arezou; Rekas Agata; Price William E; Carver John A
The effect of dextran on subunit exchange of the molecular chaperone alphaA-crystallin.
Biochimica et biophysica acta 2007;1774(1):102-11.
2007: Ecroyd Heath; Meehan Sarah; Horwitz Joseph; Aquilina J Andrew; Benesch Justin L P; Robinson Carol V; Macphee Cait E; Carver John A
Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity.
The Biochemical journal 2007;401(1):129-41.
2007: Treweek Teresa M; Ecroyd Heath; Williams Danielle M; Meehan Sarah; Carver John A; Walker Mark J
Site-directed mutations in the C-terminal extension of human alphaB-crystallin affect chaperone function and block amyloid fibril formation.
PloS one 2007;2(10):e1046.
2005: Thorn David C; Meehan Sarah; Sunde Margaret; Rekas Agata; Gras Sally L; MacPhee Cait E; Dobson Christopher M; Wilson Mark R; Carver John A
Amyloid fibril formation by bovine milk kappa-casein and its inhibition by the molecular chaperones alphaS- and beta-casein.
Biochemistry 2005;44(51):17027-36.
2005: Morgan Philip E; Treweek Teresa M; Lindner Robyn A; Price William E; Carver John A
Casein proteins as molecular chaperones.
Journal of agricultural and food chemistry 2005;53(7):2670-83.
2005: Treweek Teresa M; Rekas Agata; Lindner Robyn A; Walker Mark J; Aquilina J Andrew; Robinson Carol V; Horwitz Joseph; Perng Ming Der; Quinlan Roy A; Carver John A
R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable.
The FEBS journal 2005;272(3):711-24.
2004: Rekas Agata; Adda Christopher G; Andrew Aquilina J; Barnham Kevin J; Sunde Margaret; Galatis Denise; Williamson Nicholas A; Masters Colin L; Anders Robin F; Robinson Carol V; Cappai Roberto; Carver John A
Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity.
Journal of molecular biology 2004;340(5):1167-83.
2004: Apponyi Margit A; Pukala Tara L; Brinkworth Craig S; Maselli Vita M; Bowie John H; Tyler Michael J; Booker Grant W; Wallace John C; Carver John A; Separovic Frances; Doyle Jason; Llewellyn Lyndon E
Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.
Peptides 2004;25(6):1035-54.
2004: Pukala Tara L; Brinkworth Craig S; Carver John A; Bowie John H
Investigating the importance of the flexible hinge in caerin 1.1: solution structures and activity of two synthetically modified caerin peptides.
Biochemistry 2004;43(4):937-44.
2004: Meehan Sarah; Berry Yoke; Luisi Ben; Dobson Christopher M; Carver John A; MacPhee Cait E
Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation.
The Journal of biological chemistry 2004;279(5):3413-9.
2003: Carver John A; Rekas Agata; Thorn David C; Wilson Mark R
Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?
IUBMB life 2003;55(12):661-8.
2003: Devlin Glyn L; Carver John A; Bottomley Stephen P
The selective inhibition of serpin aggregation by the molecular chaperone, alpha-crystallin, indicates a nucleation-dependent specificity.
The Journal of biological chemistry 2003;278(49):48644-50.
2003: Brinkworth Craig S; Carver John A; Wegener Kate L; Doyle Jason; Llewellyn Lyndon E; Bowie John H
The solution structure of frenatin 3, a neuronal nitric oxide synthase inhibitor from the giant tree frog, Litoria infrafrenata.
Biopolymers 2003;70(3):424-34.
2003: Wegener Kate L; Carver John A; Bowie John H
The solution structures and activity of caerin 1.1 and caerin 1.4 in aqueous trifluoroethanol and dodecylphosphocholine micelles.
Biopolymers 2003;69(1):42-59.
2003: Doyle Jason; Brinkworth Craig S; Wegener Kate L; Carver John A; Llewellyn Lyndon E; Olver Ian N; Bowie John H; Wabnitz Paul A; Tyler Michael J
nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1.
European journal of biochemistry / FEBS 2003;270(6):1141-53.
2002: Poon Stephen; Rybchyn Mark S; Easterbrook-Smith Simon B; Carver John A; Pankhurst Greg J; Wilson Mark R
Mildly acidic pH activates the extracellular molecular chaperone clusterin.
The Journal of biological chemistry 2002;277(42):39532-40.
2002: Lampi Kirsten J; Kim Yung H; Bächinger Hans Peter; Boswell Bruce A; Lindner Robyn A; Carver John A; Shearer Thomas R; David Larry L; Kapfer Deborah M
Decreased heat stability and increased chaperone requirement of modified human betaB1-crystallins.
Molecular vision 2002;8():359-66.
2002: Carver John A; Lindner Robyn A; Lyon Charles; Canet Denis; Hernandez Helena; Dobson Christopher M; Redfield Christina
The interaction of the molecular chaperone alpha-crystallin with unfolding alpha-lactalbumin: a structural and kinetic spectroscopic study.
Journal of molecular biology 2002;318(3):815-27.
2002: Smulders Ronald H P H; van Dijk Marjon A M; Hoevenaars Simon; Lindner Robyn A; Carver John A; de Jong Wilfried W
The eye lens protein alphaA-crystallin of the blind mole rat Spalax ehrenbergi: effects of altered functional constraints.
Experimental eye research 2002;74(2):285-91.
2002: Poon Stephen; Treweek Teresa M; Wilson Mark R; Easterbrook-Smith Simon B; Carver John A
Clusterin is an extracellular chaperone that specifically interacts with slowly aggregating proteins on their off-folding pathway.
FEBS letters 2002;513(2-3):259-66.
2002: Lakins Johnathon N; Poon Stephen; Easterbrook-Smith Simon B; Carver John A; Tenniswood Martin P R; Wilson Mark R
Evidence that clusterin has discrete chaperone and ligand binding sites.
Biochemistry 2002;41(1):282-91.
2001: Hatters D M; Lindner R A; Carver J A; Howlett G J
The molecular chaperone, alpha-crystallin, inhibits amyloid formation by apolipoprotein C-II.
The Journal of biological chemistry 2001;276(36):33755-61.
2001: Lindner R A; Treweek T M; Carver J A
The molecular chaperone alpha-crystallin is in kinetic competition with aggregation to stabilize a monomeric molten-globule form of alpha-lactalbumin.
The Biochemical journal 2001;354(Pt 1):79-87.
2000: Aquilina J A; Carver J A; Truscott R J
Polypeptide modification and cross-linking by oxidized 3-hydroxykynurenine.
Biochemistry 2000;39(51):16176-84.
2000: Poon S; Easterbrook-Smith S B; Rybchyn M S; Carver J A; Wilson M R
Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state.
Biochemistry 2000;39(51):15953-60.
2000: Rozek T; Wegener K L; Bowie J H; Olver I N; Carver J A; Wallace J C; Tyler M J
The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
European journal of biochemistry / FEBS 2000;267(17):5330-41.
2000: Treweek T M; Lindner R A; Mariani M; Carver J A
The small heat-shock chaperone protein, alpha-crystallin, does not recognize stable molten globule states of cytosolic proteins.
Biochimica et biophysica acta 2000;1481(1):175-88.
2000: Lindner R A; Carver J A; Ehrnsperger M; Buchner J; Esposito G; Behlke J; Lutsch G; Kotlyarov A; Gaestel M
Mouse Hsp25, a small shock protein. The role of its C-terminal extension in oligomerization and chaperone action.
European journal of biochemistry / FEBS 2000;267(7):1923-32.
2000: Chia B C; Carver J A; Mulhern T D; Bowie J H
Maculatin 1.1, an anti-microbial peptide from the Australian tree frog, Litoria genimaculata solution structure and biological activity.
European journal of biochemistry / FEBS 2000;267(7):1894-908.
2000: Garner B; Shaw D C; Lindner R A; Carver J A; Truscott R J
Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract.
Biochimica et biophysica acta 2000;1476(2):265-78.
1999: Wegener K L; Wabnitz P A; Carver J A; Bowie J H; Chia B C; Wallace J C; Tyler M J
Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.
European journal of biochemistry / FEBS 1999;265(2):627-37.
1999: Aquilina J A; Carver J A; Truscott R J
Elucidation of a novel polypeptide cross-link involving 3-hydroxykynurenine.
Biochemistry 1999;38(35):11455-64.
1999: Chia B C; Carver J A; Mulhern T D; Bowie J H
The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii.
The journal of peptide research : official journal of the American Peptide Society 1999;54(2):137-45.
1999: Garner B; Vazquez S; Griffith R; Lindner R A; Carver J A; Truscott R J
Identification of glutathionyl-3-hydroxykynurenine glucoside as a novel fluorophore associated with aging of the human lens.
The Journal of biological chemistry 1999;274(30):20847-54.
1999: Werten P J; Lindner R A; Carver J A; de Jong W W
Formation of betaA3/betaB2-crystallin mixed complexes: involvement of N- and C-terminal extensions.
Biochimica et biophysica acta 1999;1432(2):286-92.
1999: Carver J A
Probing the structure and interactions of crystallin proteins by NMR spectroscopy.
Progress in retinal and eye research 1999;18(4):431-62.
1999: Humphreys D T; Carver J A; Easterbrook-Smith S B; Wilson M R
Clusterin has chaperone-like activity similar to that of small heat shock proteins.
The Journal of biological chemistry 1999;274(11):6875-81.
1998: van de Klundert F A; Smulders R H; Gijsen M L; Lindner R A; Jaenicke R; Carver J A; de Jong W W
The mammalian small heat-shock protein Hsp20 forms dimers and is a poor chaperone.
European journal of biochemistry / FEBS 1998;258(3):1014-21.
1998: Lindner R A; Kapur A; Mariani M; Titmuss S J; Carver J A
Structural alterations of alpha-crystallin during its chaperone action.
European journal of biochemistry / FEBS 1998;258(1):170-83.
1998: Carver J A; Lindner R A
NMR spectroscopy of alpha-crystallin. Insights into the structure, interactions and chaperone action of small heat-shock proteins.
International journal of biological macromolecules 1998;22(3-4):197-209.
1997: Lindner R A; Kapur A; Carver J A
The interaction of the molecular chaperone, alpha-crystallin, with molten globule states of bovine alpha-lactalbumin.
The Journal of biological chemistry 1997;272(44):27722-9.
1997: Wong H; Bowie J H; Carver J A
The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.
European journal of biochemistry / FEBS 1997;247(2):545-57.
1997: Aquilina J A; Carver J A; Truscott R J
Oxidation products of 3-hydroxykynurenine bind to lens proteins: relevance for nuclear cataract.
Experimental eye research 1997;64(5):727-35.
1996: Carver J A; Nicholls K A; Aquilina J A; Truscott R J
Age-related changes in bovine alpha-crystallin and high-molecular-weight protein.
Experimental eye research 1996;63(6):639-47.
1996: Werten P J; Carver J A; Jaenicke R; de Jong W W
The elusive role of the N-terminal extension of beta A3- and beta A1-crystallin.
Protein engineering 1996;9(11):1021-8.
1996: Smulders RHPH; Carver J A; Lindner R A; van Boekel M A; Bloemendal H; de Jong W W
Immobilization of the C-terminal extension of bovine alphaA-crystallin reduces chaperone-like activity.
The Journal of biological chemistry 1996;271(46):29060-6.
1996: Mar R I; Carver J A; Sheil M M; Boschenok J; Fu S; Shaw D C
Primary structure of trypsin inhibitors from Sicyos australis.
Phytochemistry 1996;41(5):1265-74.
1996: Le Breton E R; Carver J A
Solution conformation of bovine lens alpha- and betaB2-crystallin terminal extensions.
International journal of peptide and protein research 1996;47(1-2):9-19.
1995: Carver J A; Guerreiro N; Nicholls K A; Truscott R J
On the interaction of alpha-crystallin with unfolded proteins.
Biochimica et biophysica acta 1995;1252(2):251-60.
1995: Carver J A; Esposito G; Schwedersky G; Gaestel M
1H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 18 amino acids.
FEBS letters 1995;369(2-3):305-10.
1995: Nonato M G; Truscott R J; Carver J A; Hemling M E; Garson M J
Glucoindole alkaloids from Ophiorrhiza acuminata.
Planta medica 1995;61(3):278-80.
1995: Kilby G W; Carver J A; Zhu J L; Sheil M M; Truscott R J
Loss of the C-terminal serine residue from bovine beta B2-crystallin.
Experimental eye research 1995;60(5):465-9.
1994: Cooper P G; Aquilina J A; Truscott R J; Carver J A
Supramolecular order within the lens: 1H NMR spectroscopic evidence for specific crystallin-crystallin interactions.
Experimental eye research 1994;59(5):607-16.
1994: Carver J A; Aquilina J A; Truscott R J
A possible chaperone-like quaternary structure for alpha-crystallin.
Experimental eye research 1994;59(2):231-4.
1994: Cooper P G; Carver J A; Aquilina J A; Ralston G B; Truscott R J
A 1H NMR spectroscopic comparison of gamma S- and gamma B-crystallins.
Experimental eye research 1994;59(2):211-20.
1994: Truscott R J; Wood A M; Carver J A; Sheil M M; Stutchbury G M; Zhu J; Kilby G W
A new UV-filter compound in human lenses.
FEBS letters 1994;348(2):173-6.
1994: Carver J A; Aquilina J A; Cooper P G; Williams G A; Truscott R J
Alpha-crystallin: molecular chaperone and protein surfactant.
Biochimica et biophysica acta 1994;1204(2):195-206.
1993: Carver J A; Aquilina J A; Truscott R J
An investigation into the stability of alpha-crystallin by NMR spectroscopy; evidence for a two-domain structure.
Biochimica et biophysica acta 1993;1164(1):22-8.
1993: Cooper P G; Carver J A; Truscott R J
1H-NMR spectroscopy of bovine lens beta-crystallin. The role of the beta B2-crystallin C-terminal extension in aggregation.
European journal of biochemistry / FEBS 1993;213(1):321-8.
1993: Carver J A; Cooper P G; Truscott R J
1H-NMR spectroscopy of beta B2-crystallin from bovine eye lens. Conformation of the N- and C-terminal extensions.
European journal of biochemistry / FEBS 1993;213(1):313-20.
1992: Carver J A; Aquilina J A; Truscott R J; Ralston G B
Identification by 1H NMR spectroscopy of flexible C-terminal extensions in bovine lens alpha-crystallin.
FEBS letters 1992;311(2):143-9.
1992: Truscott R J; Carver J A; Thorpe A; Douglas R H
Identification of 3-hydroxykynurenine as the lens pigment in the gourami Trichogaster trichopterus.
Experimental eye research 1992;54(6):1015-7.
1990: Carver J A; Collins J G
NMR identification of a partial helical conformation for bombesin in solution.
European journal of biochemistry / FEBS 1990;187(3):645-50.
1988: Carver J A; Baldwin G S; Keech D B; Bais R; Wallace J C
Inactivation of chicken liver pyruvate carboxylase by 1,10-phenanthroline.
The Biochemical journal 1988;252(2):501-7.
1988: Bazzo R; Tappin M J; Pastore A; Harvey T S; Carver J A; Campbell I D
The structure of melittin. A 1H-NMR study in methanol.
European journal of biochemistry / FEBS 1988;173(1):139-46.
1988: Carver J A
A two dimensional 1H NMR study of the solution conformation of gastrin releasing peptide.
Biochemical and biophysical research communications 1988;150(2):552-60.
1987: Carver J A
The conformation of bombesin in solution as determined by two-dimensional 1H-NMR techniques.
European journal of biochemistry / FEBS 1987;168(1):193-9.

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