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javier sancho

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TOP 3
S Ayuso-Tejedor; O Abián; Adrián Velázquez-Campoy; javier sancho
Mechanism of FMN Binding to the Apoflavodoxin from Helicobacter pylori.
Sara Ayuso-Tejedor; Shingo Nishikori; Takashi Okuno; Teru Ogura; javier sancho
FtsH cleavage of non-native conformations of proteins.
Sara Ayuso-Tejedor; Vladimir Espinosa Angarica; Marta Bueno; Luis A Campos; Olga Abián; Pau Bernadó; javier sancho; M Angeles Jiménez
Design and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteins.

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All Publications

2011: S Ayuso-Tejedor; O Abián; Adrián Velázquez-Campoy; javier sancho
Mechanism of FMN Binding to the Apoflavodoxin from Helicobacter pylori.
Biochemistry 2011;50(40):8703-11.
2010: Sara Ayuso-Tejedor; Shingo Nishikori; Takashi Okuno; Teru Ogura; javier sancho
FtsH cleavage of non-native conformations of proteins.
Journal of structural biology 2010;171(2):117-24.
2010: Sara Ayuso-Tejedor; Vladimir Espinosa Angarica; Marta Bueno; Luis A Campos; Olga Abián; Pau Bernadó; javier sancho; M Angeles Jiménez
Design and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteins.
Journal of molecular biology 2010;400(4):922-34.
2010: Xabier Arias-Moreno; Santiago Cuesta-Lopez; Oscar Millet; javier sancho; Adrian Velazquez-Campoy
Thermodynamics of protein-cation interaction: Ca(+2) and Mg(+2) binding to the fifth binding module of the LDL receptor.
Proteins 2010;78(4):950-61.
2010: Miriam Alías; Sara Ayuso-Tejedor; Juan Fernandez-Recio; Carlos Cativiela; javier sancho
Helix propensities of conformationally restricted amino acids. Non-natural substitutes for helix breaking proline and helix forming alanine.
Organic & biomolecular chemistry 2010;8(4):788-92.
2010: Raymond C Stevens; javier sancho; Aurora Martinez
Rescue of misfolded proteins and stabilization by small molecules.
Methods in molecular biology (Clifton, N.J.) 2010;648():313-24.
2010: Bruno Contreras-Moreira; javier sancho; Vladimir Espinosa Angarica
Comparison of DNA binding across protein superfamilies.
Proteins 2010;78(1):52-62.
2009: Nunilo Cremades; Adrián Velázquez-Campoy; Marta Martínez-Júlvez; José L Neira; Inmaculada Pérez-Dorado; Juan A Hermoso; Pilar Jiménez; Angel Lanas; Paul S Hoffman; javier sancho
Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection.
ACS chemical biology 2009;4(11):928-38.
2009: Rubén Gil-Redondo; Jorge Estrada; Antonio Morreale; Fernando Herranz; javier sancho; Angel R Ortiz
VSDMIP: virtual screening data management on an integrated platform.
Journal of computer-aided molecular design 2009;23(3):171-84.
2009: Jorge Estrada; Pau Bernadó; Martin Blackledge; javier sancho
ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble.
BMC bioinformatics 2009;10():104.
2008: Jesús Gonzalo-Asensio; Carlos Y Soto; Ainhoa Arbués; javier sancho; María del Carmen Menéndez; María J García; Brigitte Gicquel; Carlos Martín
The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv.
Journal of bacteriology 2008;190(21):7068-78.
2008: Xabier Arias-Moreno; Adrián Velazquez-Campoy; José Carlos Rodríguez; Miguel Pocoví; javier sancho
Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.
The Journal of biological chemistry 2008;283(33):22670-9.
2008: Angel L Pey; Ming Ying; Nunilo Cremades; Adrian Velazquez-Campoy; Tanja Scherer; Beat Thöny; javier sancho; Aurora Martinez
Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria.
The Journal of clinical investigation 2008;118(8):2858-67.
2008: Nunilo Cremades; javier sancho
Molten globule and native state ensemble of Helicobacter pylori flavodoxin: can crowding, osmolytes or cofactors stabilize the native conformation relative to the molten globule?
Biophysical journal 2008;95(4):1913-27.
2008: Xabier Arias-Moreno; Joan L Arolas; Francesc Aviles; javier sancho; Salvador Ventura
Scrambled isomers as key intermediates in the oxidative folding of ligand binding module 5 of the low density lipoprotein receptor.
The Journal of biological chemistry 2008;283(20):13627-37.
2008: Nunilo Cremades; Marta Bueno; José L Neira; Adrián Velázquez-Campoy; javier sancho
Conformational stability of Helicobacter pylori flavodoxin: fit to function at pH 5.
The Journal of biological chemistry 2008;283(5):2883-95.
2008: Nunilo Cremades; Adrian Velazquez-Campoy; Ernesto Freire; javier sancho
The flavodoxin from Helicobacter pylori: structural determinants of thermostability and FMN cofactor binding.
Biochemistry 2008;47(2):627-39.
2007: Marta Martínez-Júlvez; Nunilo Cremades; Marta Bueno; Inmaculada Pérez-Dorado; Celia Maya; Santiago Cuesta-Lopez; Diego Prada; Fernando Falo; Juan A Hermoso; javier sancho
Common conformational changes in flavodoxins induced by FMN and anion binding: the structure of Helicobacter pylori apoflavodoxin.
Proteins 2007;69(3):581-94.
2007: Marta Bueno; Carlos J Camacho; javier sancho
SIMPLE estimate of the free energy change due to aliphatic mutations: superior predictions based on first principles.
Proteins 2007;68(4):850-62.
2007: Martin St Maurice; Nunilo Cremades; Matthew A Croxen; Gary Sisson; javier sancho; Paul S Hoffman
Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni.
Journal of bacteriology 2007;189(13):4764-73.
2007: Santiago Cuesta-Lopez; Fernando Falo; javier sancho
Computational diagnosis of protein conformational diseases: short molecular dynamics simulations reveal a fast unfolding of r-LDL mutants that cause familial hypercholesterolemia.
Proteins 2007;66(1):87-95.
2006: Pau Bernadó; Martin Blackledge; javier sancho
Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles.
Biophysical journal 2006;91(12):4536-43.
2006: Nunilo Cremades; javier sancho; Ernesto Freire
The native-state ensemble of proteins provides clues for folding, misfolding and function.
Trends in biochemical sciences 2006;31(9):494-6.
2006: Jon López-Llano; Luis A Campos; javier sancho
Alpha-helix stabilization by alanine relative to glycine: roles of polar and apolar solvent exposures and of backbone entropy.
Proteins 2006;64(3):769-78.
2006: Marta Bueno; Luis A Campos; Jorge Estrada; javier sancho
Energetics of aliphatic deletions in protein cores.
Protein science : a publication of the Protein Society 2006;15(8):1858-72.
2006: Marta Bueno; Sara Ayuso-Tejedor; javier sancho
Do proteins with similar folds have similar transition state structures? A diffuse transition state of the 169 residue apoflavodoxin.
Journal of molecular biology 2006;359(3):813-24.
2006: Luis A Campos; javier sancho
Native-specific stabilization of flavodoxin by the FMN cofactor: structural and thermodynamical explanation.
Proteins 2006;63(3):581-94.
2006: Marta Bueno; Nunilo Cremades; José L Neira; javier sancho
Filling small, empty protein cavities: structural and energetic consequences.
Journal of molecular biology 2006;358(3):701-12.
2006: javier sancho
Flavodoxins: sequence, folding, binding, function and beyond.
Cellular and molecular life sciences : CMLS 2006;63(7-8):855-64.
2006: Jon López-Llano; Luis A Campos; Marta Bueno; javier sancho
Equilibrium phi-analysis of a molten globule: the 1-149 apoflavodoxin fragment.
Journal of molecular biology 2006;356(2):354-66.
2005: María C Lidón-Moya; Francisco Barrera; Marta Bueno; Raúl Pérez-Jiménez; javier sancho; Mauricio G Mateu; José L Neira
An extensive thermodynamic characterization of the dimerization domain of the HIV-1 capsid protein.
Protein science : a publication of the Protein Society 2005;14(9):2387-404.
2005: Pilar Alfonso; Sandra Pampín; Jorge Estrada; José C Rodríguez-Rey; Pilar Giraldo; javier sancho; Miguel Pocoví
Miglustat (NB-DNJ) works as a chaperone for mutated acid beta-glucosidase in cells transfected with several Gaucher disease mutations.
Blood cells, molecules & diseases 2005;35(2):268-76.
2005: Claudia Machicado; Jon López-Llano; Santiago Cuesta-Lopez; Marta Bueno; javier sancho
Design of ligand binding to an engineered protein cavity using virtual screening and thermal up-shift evaluation.
Journal of computer-aided molecular design 2005;19(6):421-43.
2005: Nunilo Cremades; Marta Bueno; Miguel Toja; javier sancho
Towards a new therapeutic target: Helicobacter pylori flavodoxin.
Biophysical chemistry 2005;115(2-3):267-76.
2005: Luis A Campos; Santiago Cuesta-Lopez; Jon López-Llano; Fernando Falo; javier sancho
A double-deletion method to quantifying incremental binding energies in proteins from experiment: example of a destabilizing hydrogen bonding pair.
Biophysical journal 2005;88(2):1311-21.
2004: Isabel Nogués; Luis A Campos; javier sancho; Carlos Gómez-Moreno; Stephen G Mayhew; Milagros Medina
Role of neighboring FMN side chains in the modulation of flavin reduction potentials and in the energetics of the FMN:apoprotein interaction in Anabaena flavodoxin.
Biochemistry 2004;43(48):15111-21.
2004: Luis A Campos; Marta Bueno; Jon Lopez-Llano; María Angeles Jiménez; javier sancho
Structure of stable protein folding intermediates by equilibrium phi-analysis: the apoflavodoxin thermal intermediate.
Journal of molecular biology 2004;344(1):239-55.
2004: Luis A Campos; Maria M Garcia-Mira; Raquel Godoy-Ruiz; Jose M Sanchez-Ruiz; javier sancho
Do proteins always benefit from a stability increase? Relevant and residual stabilisation in a three-state protein by charge optimisation.
Journal of molecular biology 2004;344(1):223-37.
2004: Jon López-Llano; Susana Maldonado; Shandya Jain; Anabel Lostao; Raquel Godoy-Ruiz; Jose M Sanchez-Ruiz; Manuel Cortijo; Juan Fernandez-Recio; javier sancho
The long and short flavodoxins: II. The role of the differentiating loop in apoflavodoxin stability and folding mechanism.
The Journal of biological chemistry 2004;279(45):47184-91.
2004: Jon López-Llano; Susana Maldonado; Marta Bueno; Anabel Lostao; Maria Angeles-Jiménez; Mariá P Lillo; javier sancho
The long and short flavodoxins: I. The role of the differentiating loop in apoflavodoxin structure and FMN binding.
The Journal of biological chemistry 2004;279(45):47177-83.
2003: Abdelghani Iddar; Luis A Campos; javier sancho; Aurelio Serrano; Abdelaziz Soukri
Different thermostability of skeletal muscle glyceraldehyde-3-phosphate dehydrogenase from hibernating and euthermic jerboa (Jaculus orientalis).
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003;35(10):891-6.
2003: Anabel Lostao; Fatna Daoudi; María Pilar Irún; Alvaro Ramon; Concha Fernández-Cabrera; Antonio Romero; javier sancho
How FMN binds to anabaena apoflavodoxin: a hydrophobic encounter at an open binding site.
The Journal of biological chemistry 2003;278(26):24053-61.
2003: Luis A Campos; javier sancho
The active site of pepsin is formed in the intermediate conformation dominant at mildly acidic pH.
FEBS letters 2003;538(1-3):89-95.
2003: Rebeca Acín-Pérez; Maria Pilar Bayona-Bafaluy; Marta Bueno; Claudia Machicado; Patricio Fernández-Silva; Acisclo Pérez-Martos; Julio Montoya; Manuel J López-Pérez; javier sancho; José Antonio Enríquez
An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA.
Human molecular genetics 2003;12(3):329-39.
2002: Idolka Pedroso; María Pilar Irún; Claudia Machicado; javier sancho
Four-state equilibrium unfolding of an scFv antibody fragment.
Biochemistry 2002;41(31):9873-84.
2002: Claudia Machicado; Marta Bueno; javier sancho
Predicting the structure of protein cavities created by mutation.
Protein engineering 2002;15(8):669-75.
2002: José L Casaus; José A Navarro; Manuel Hervás; Anabel Lostao; Miguel A De la Rosa; Carlos Gómez-Moreno; javier sancho; Milagros Medina
Anabaena sp. PCC 7119 flavodoxin as electron carrier from photosystem I to ferredoxin-NADP+ reductase. Role of Trp(57) and Tyr(94).
The Journal of biological chemistry 2002;277(25):22338-44.
2002: javier sancho; Marta Bueno; Luis A Campos; Juan Fernandez-Recio; María Pilar Irún; Jon López; Claudia Machicado; Idolka Pedroso; Miguel Toja
The 'relevant' stability of proteins with equilibrium intermediates.
TheScientificWorldJournal 2002;2():1209-15.
2002: Susana Maldonado; María Pilar Irún; Luis A Campos; José Antonio Rubio; Alejandra Luquita; Anabel Lostao; Renjie Wang; Bertrand García-Moreno E; javier sancho
Salt-induced stabilization of apoflavodoxin at neutral pH is mediated through cation-specific effects.
Protein science : a publication of the Protein Society 2002;11(5):1260-73.
2001: Juan Fernandez-Recio; C G Genzor; javier sancho
Apoflavodoxin folding mechanism: an alpha/beta protein with an essentially off-pathway intermediate.
Biochemistry 2001;40(50):15234-45.
2001: GM Langdon; María Angeles Jiménez; C G Genzor; Susana Maldonado; javier sancho; Manuel Rico
Anabaena apoflavodoxin hydrogen exchange: on the stable exchange core of the alpha/beta(21345) flavodoxin-like family.
Proteins 2001;43(4):476-88.
2001: María Pilar Irún; Maria M Garcia-Mira; Jose M Sanchez-Ruiz; javier sancho
Native hydrogen bonds in a molten globule: the apoflavodoxin thermal intermediate.
Journal of molecular biology 2001;306(4):877-88.
2001: María Pilar Irún; Susana Maldonado; javier sancho
Stabilization of apoflavodoxin by replacing hydrogen-bonded charged Asp or Glu residues by the neutral isosteric Asn or Gln.
Protein engineering 2001;14(3):173-81.
2000: Anabel Lostao; M El Harrous; Fatna Daoudi; Antonio Romero; Antonio Parody-Morreale; javier sancho
Dissecting the energetics of the apoflavodoxin-FMN complex.
The Journal of biological chemistry 2000;275(13):9518-26.
1999: Milagros Medina; Anabel Lostao; javier sancho; Carlos Gómez-Moreno; Richard Cammack; Pablo J Alonso; Jesús I Martínez
Electron-nuclear double resonance and hyperfine sublevel correlation spectroscopic studies of flavodoxin mutants from Anabaena sp. PCC 7119.
Biophysical journal 1999;77(3):1712-20.
1999: Juan Fernandez-Recio; Antonio Romero; javier sancho
Energetics of a hydrogen bond (charged and neutral) and of a cation-pi interaction in apoflavodoxin.
Journal of molecular biology 1999;290(1):319-30.
1998: Susana Maldonado; Anabel Lostao; María Pilar Irún; J Férnandez-Recio; C Gustavo Genzor; E Begoña González; J A Rubio; Alejandra Luquita; Fatna Daoudi; javier sancho
Apoflavodoxin: structure, stability, and FMN binding.
Biochimie 1998;80(10):813-20.
1998: Susana Maldonado; María Angeles Jiménez; GM Langdon; javier sancho
Cooperative stabilization of a molten globule apoflavodoxin fragment.
Biochemistry 1998;37(30):10589-96.
1998: Juan Fernandez-Recio; javier sancho
Intrahelical side chain interactions in alpha-helices: poor correlation between energetics and frequency.
FEBS letters 1998;429(1):99-103.
1997: Anabel Lostao; Carlos Gómez-Moreno; Stephen G Mayhew; javier sancho
Differential stabilization of the three FMN redox forms by tyrosine 94 and tryptophan 57 in flavodoxin from Anabaena and its influence on the redox potentials.
Biochemistry 1997;36(47):14334-44.
1997: Juan Fernandez-Recio; A Vázquez; C Civera; P Sevilla; javier sancho
The tryptophan/histidine interaction in alpha-helices.
Journal of molecular biology 1997;267(1):184-97.
1996: C G Genzor; A Beldarraín; Carlos Gómez-Moreno; J L López-Lacomba; Manuel Cortijo; javier sancho
Conformational stability of apoflavodoxin.
Protein science : a publication of the Protein Society 1996;5(7):1376-88.
1996: C G Genzor; A Perales-Alcón; javier sancho; A Romero
Closure of a tyrosine/tryptophan aromatic gate leads to a compact fold in apo flavodoxin.
Nature structural biology 1996;3(4):329-32.
1994: A D Kippen; javier sancho; Alan Fersht
Folding of barnase in parts.
Biochemistry 1994;33(12):3778-86.
1993: S Vuilleumier; javier sancho; R Loewenthal; AR Fersht
Circular dichroism studies of barnase and its mutants: characterization of the contribution of aromatic side chains.
Biochemistry 1993;32(39):10303-13.
1993: R Loewenthal; javier sancho; T Reinikainen; Alan Fersht
Long-range surface charge-charge interactions in proteins. Comparison of experimental results with calculations from a theoretical method.
Journal of molecular biology 1993;232(2):574-83.
1992: L Serrano; javier sancho; M Hirshberg; Alan Fersht
Alpha-helix stability in proteins. I. Empirical correlations concerning substitution of side-chains at the N and C-caps and the replacement of alanine by glycine or serine at solvent-exposed surfaces.
Journal of molecular biology 1992;227(2):544-59.
1992: R Loewenthal; javier sancho; Alan Fersht
Histidine-aromatic interactions in barnase. Elevation of histidine pKa and contribution to protein stability.
Journal of molecular biology 1992;224(3):759-70.
1992: javier sancho; José L Neira; Alan Fersht
An N-terminal fragment of barnase has residual helical structure similar to that in a refolding intermediate.
Journal of molecular biology 1992;224(3):749-58.
1992: javier sancho; Alan Fersht
Dissection of an enzyme by protein engineering. The N and C-terminal fragments of barnase form a native-like complex with restored enzymic activity.
Journal of molecular biology 1992;224(3):741-7.
1992: L Serrano; J L Neira; javier sancho; Alan Fersht
Effect of alanine versus glycine in alpha-helices on protein stability.
Nature 1992;356(6368):453-5.
1992: javier sancho; L Serrano; Alan Fersht
Histidine residues at the N- and C-termini of alpha-helices: perturbed pKas and protein stability.
Biochemistry 1992;31(8):2253-8.
1992: K Willaert; R Loewenthal; javier sancho; M Froeyen; A Fersht; Yves Engelborghs
Determination of the excited-state lifetimes of the tryptophan residues in barnase, via multifrequency phase fluorometry of tryptophan mutants.
Biochemistry 1992;31(3):711-6.
1992: Alan Fersht; A Matouschek; javier sancho; L Serrano; S Vuilleumier
Pathway of protein folding.
Faraday discussions 1992;(93):183-93.
1991: javier sancho; E M Meiering; Alan Fersht
Mapping transition states of protein unfolding by protein engineering of ligand-binding sites.
Journal of molecular biology 1991;221(3):1007-14.
1991: R Loewenthal; javier sancho; Alan Fersht
Fluorescence spectrum of barnase: contributions of three tryptophan residues and a histidine-related pH dependence.
Biochemistry 1991;30(27):6775-9.
1991: javier sancho; Carlos Gómez-Moreno
Interaction of ferredoxin-NADP+ reductase from Anabaena with its substrates.
Archives of biochemistry and biophysics 1991;288(1):231-8.
1990: javier sancho; Milagros Medina; Carlos Gómez-Moreno
Arginyl groups involved in the binding of Anabaena ferredoxin--NADP+ reductase to NADP+ and to ferredoxin.
European journal of biochemistry / FEBS 1990;187(1):39-48.
1989: J J Pueyo; javier sancho; Dale E Edmondson; Carlos Gómez-Moreno
Preparation and properties of a cross-linked complex between ferredoxin--NADP+ reductase and flavodoxin.
European journal of biochemistry / FEBS 1989;183(3):539-44.
1988: javier sancho; M L Peleato; C Gomez-Moreno; Dale E Edmondson
Purification and properties of ferredoxin-NADP+ oxidoreductase from the nitrogen-fixing cyanobacteria Anabaena variabilis.
Archives of biochemistry and biophysics 1988;260(1):200-7.