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Timothy Doherty

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Niaina Rakotosamimanana; Lova H Andriamihantasoa; Timothy Doherty; Brigitte Gicquel; Vincent Richard; Jean-Louis Soares; Alimuddin Zumla; Voahangy Rasolofo Razanamparany
Expression of TNF-Alpha-Dependent Apoptosis-Related Genes in the Peripheral Blood of Malagasy Subjects with Tuberculosis.
Véronique Corbière; Timothy Doherty; Sophie Lecher; Camille Locht; Gaelle Pottier; Kinda Schepers; Virginie Verscheure; Florence Bonkain; Françoise Mascart
Risk stratification of latent tuberculosis defined by combined interferon gamma release assays.
Jaap T van Dissel; Darius Soonawala; Simone A Joosten; Corine Prins; Sandra M Arend; Peter Bang; Pernille Nyholm Tingskov; Karen Lingnau; Jan Nouta; Søren T Hoff; Ida Rosenkrands; Ingrid Kromann; Tom H M Ottenhoff; Timothy Doherty; Peter Andersen
Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection.

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All Publications

2013: Niaina Rakotosamimanana; Lova H Andriamihantasoa; Timothy Doherty; Brigitte Gicquel; Vincent Richard; Jean-Louis Soares; Alimuddin Zumla; Voahangy Rasolofo Razanamparany
Expression of TNF-Alpha-Dependent Apoptosis-Related Genes in the Peripheral Blood of Malagasy Subjects with Tuberculosis.
PloS one 2013;8(4):e61154.
2012: Véronique Corbière; Timothy Doherty; Sophie Lecher; Camille Locht; Gaelle Pottier; Kinda Schepers; Virginie Verscheure; Florence Bonkain; Françoise Mascart
Risk stratification of latent tuberculosis defined by combined interferon gamma release assays.
PloS one 2012;7(8):e43285.
2011: Jaap T van Dissel; Darius Soonawala; Simone A Joosten; Corine Prins; Sandra M Arend; Peter Bang; Pernille Nyholm Tingskov; Karen Lingnau; Jan Nouta; Søren T Hoff; Ida Rosenkrands; Ingrid Kromann; Tom H M Ottenhoff; Timothy Doherty; Peter Andersen
Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection.
Vaccine 2011;29(11):2100-9.
2010: Sammy Place; Virginie Verscheure; Nour de San; Jean-Michel Hougardy; Kinda Schepers; Violette Dirix; Anne Dediste; Olivier Michel; Annie Drowart; Sabine D Allard; Timothy Doherty; Sophie Lecher; Camille Locht; Françoise Mascart
Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans.
American journal of respiratory and critical care medicine 2010;182(6):848-54.
2010: C J Gallant; A Cobat; L Simkin; G F Black; K Stanley; J Hughes; Timothy Doherty; W A Hanekom; B Eley; Nulda Beyers; J-P Jaïs; P van Helden; Laurent Abel; Alexandre Alcaïs; Eileen G Hoal; Erwin Schurr
Impact of age and sex on mycobacterial immunity in an area of high tuberculosis incidence.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2010;14(8):952-9.
2010: J S L Kang; A Cherian; S H Gan; T H Lee; K C Lee; C B E Chee; Timothy Doherty; Yee-Tang Wang; G T Seah
Strong purified protein derivative responses are associated with poor mycobacterium inhibition in latent TB.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(2):348-54.
2010: Niaina Rakotosamimanana; Vaomalala Raharimanga; Soa Fy Andriamandimby; Jean-Louis Soares; Timothy Doherty; Maherisoa Ratsitorahina; Herimanana Ramarokoto; Alimuddin Zumla; Jim Huggett; Graham Rook; Vincent Richard; Brigitte Gicquel; Voahangy Rasolofo Razanamparany
Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar.
Clinical and vaccine immunology : CVI 2010;17(7):1094-103.
2010: Robert S Wallis; Madhukar Pai; Dick Menzies; Timothy Doherty; Gerhard Walzl; Mark Perkins; Alimuddin Zumla
Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice.
Lancet 2010;375(9729):1920-37.
2010: Caroline J Gallant; Aurelie Cobat; Leah Simkin; Gillian F Black; Kim Stanley; Jane Hughes; Timothy Doherty; Willem A Hanekom; Brian Eley; Nulda Beyers; Jean-Philippe Jaïs; Paul van Helden; Laurent Abel; Alexandre Alcaïs; Eileen G Hoal; Erwin Schurr
Tuberculin skin test and in vitro assays provide complementary measures of antimycobacterial immunity in children and adolescents.
Chest 2010;137(5):1071-7.
2010: Jaap T van Dissel; Sandra M Arend; Corine Prins; Peter Bang; Pernille Nyholm Tingskov; Karen Lingnau; Jan Nouta; Michèl R Klein; Ida Rosenkrands; Tom H M Ottenhoff; Ingrid Kromann; Timothy Doherty; Peter Andersen
Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers.
Vaccine 2010;28(20):3571-81.
2010: S Dhanasekaran; Timothy Doherty; John Kenneth
Comparison of different standards for real-time PCR-based absolute quantification.
Journal of immunological methods 2010;354(1-2):34-9.
2010: Robert S Wallis; Cunshan Wang; Timothy Doherty; Phillip Onyebujoh; Mahnaz Vahedi; Hannu Laang; Ole Olesen; Shreemanta Parida; Alimuddin Zumla
Biomarkers for tuberculosis disease activity, cure, and relapse.
The Lancet infectious diseases 2010;10(2):68-9.
2010: Aurelie Cobat; Caroline J Gallant; Leah Simkin; Gillian F Black; Kim Stanley; Jane Hughes; Timothy Doherty; Willem A Hanekom; Brian Eley; Nulda Beyers; Jean-Philippe Jaïs; Paul van Helden; Laurent Abel; Eileen G Hoal; Alexandre Alcaïs; Erwin Schurr
High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease.
The Journal of infectious diseases 2010;201(1):15-9.
2009: Aurelie Cobat; Caroline J Gallant; Leah Simkin; Gillian F Black; Kim Stanley; Jane Hughes; Timothy Doherty; Willem A Hanekom; Brian Eley; Jean-Philippe Jaïs; Anne Boland-Auge; Paul van Helden; Jean-Laurent Casanova; Laurent Abel; Eileen G Hoal; Erwin Schurr; Alexandre Alcaïs
Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis.
The Journal of experimental medicine 2009;206(12):2583-91.
2009: Claus Aagaard; Jes Dietrich; Timothy Doherty; Peter Andersen
TB vaccines: current status and future perspectives.
Immunology and cell biology 2009;87(4):279-86.
2009: Robert Wallis; Timothy Doherty; Phillip Onyebujoh; Mahnaz Vahedi; Hannu Laang; Ole Olesen; Shreemanta Parida; Alimuddin Zumla
Biomarkers for tuberculosis disease activity, cure, and relapse.
The Lancet infectious diseases 2009;9(3):162-72.
2008: Willem A Hanekom; Hazel M Dockrell; Tom H M Ottenhoff; Timothy Doherty; Helen Fletcher; Helen McShane; Frank F Weichold; Dan F Hoft; Shreemanta K Parida; Uli J Fruth
Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations.
PLoS medicine 2008;5(7):e145.
2008: Diana Boraschi; Markos Abebe Alemayehu; Abraham Aseffa; Francesca Chiodi; John Chisi; Gianfranco Del Prete; Timothy Doherty; Ibrahim Elhassan; Howard Engers; Ben Gyan; Ali M Harandi; Thomas Kariuki; Fred Kironde; Bourema Kouriba; Jean Langhorne; Tamás Laskay; Donata Medaglini; Ole Olesen; Philip Onyebujoh; Carla Palma; Robert Sauerwein; Elopy Sibanda; Ulrich Steinhoff; Aldo Tagliabue; Andreas Thiel; Mahnaz Vahedi; Marita Troye-Blomberg
Immunity against HIV/AIDS, malaria, and tuberculosis during co-infections with neglected infectious diseases: recommendations for the European Union research priorities.
PLoS neglected tropical diseases 2008;2(6):e255.
2007: Hanni Höhn; Cornelius Kortsik; Ingeborg Zehbe; Walter E Hitzler; K Kayser; Kirsten Freitag; Claudia Neukirch; P Andersen; Timothy Doherty; Markus J Maeurer
MHC class II tetramer guided detection of Mycobacterium tuberculosis-specific CD4+ T cells in peripheral blood from patients with pulmonary tuberculosis.
Scandinavian journal of immunology 2007;65(5):467-78.
2007: Jean-Michel Hougardy; Kinda Schepers; Sammy Place; Annie Drowart; Véronique Lechevin; Virginie Verscheure; Anne-Sophie Debrie; Timothy Doherty; Jean-Paul Van Vooren; Camille Locht; Françoise Mascart
Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis.
PloS one 2007;2(10):e926.
2005: Ann Williams; Graham J Hatch; Simon O Clark; Karen E Gooch; Kim A Hatch; Graham A Hall; Kris Huygen; Tom H M Ottenhoff; Kees L M C Franken; Peter Andersen; Timothy Doherty; Stefan H E Kaufmann; Leander Grode; Peter Seiler; Carlos Martin; Brigitte Gicquel; Stewart T Cole; Priscille Brodin; Alexander S Pym; Wilfried Dalemans; Joe Cohen; Yves Lobet; Nilu Goonetilleke; Helen McShane; Adrian Hill; Tanya Parish; Debbie Smith; neil stoker; Douglas B Lowrie; Gunilla Källenius; stefan svenson; Andrzej Pawlowski; Karen Blake; Philip D Marsh
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2005;85(1-2):29-38.
2002: Hollie Hale-Donze; Teresa Greenwell-Wild; Diane Mizel; Timothy Doherty; Delphi Chatterjee; Jan M Orenstein; Sharon M Wahl
Mycobacterium avium complex promotes recruitment of monocyte hosts for HIV-1 and bacteria.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3854-62.
2001: Johan Vekemans; Christian Lienhardt; Jackson Sillah; J G Wheeler; George Lahai; Timothy Doherty; Tumani Corrah; P Andersen; Keith P W J McAdam; Arnaud Marchant
Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia.
Infection and immunity 2001;69(10):6554-7.
1999: AL Dent; Timothy Doherty; William Paul; A Sher; Louis M Staudt
BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2098-103.
1999: Timothy Doherty; Claire Chougnet; Marco L Schito; B K Patterson; C Fox; Gene M Shearer; G Englund; Alan Sher
Infection of HIV-1 transgenic mice with Mycobacterium avium induces the expression of infectious virus selectively from a Mac-1-positive host cell population.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1506-15.
1999: Brahm H Segal; Timothy Doherty; T A Wynn; A W Cheever; A Sher; Steven M Holland
The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.
Infection and immunity 1999;67(4):1659-65.
1999: Lori L Arnold; Timothy Doherty; A W Flor; J A Simon; J Y Chou; Wai Yee Chan; Brian C Mansfield
Pregnancy-specific glycoprotein gene expression in recurrent aborters: a potential correlation to interleukin-10 expression.
American journal of reproductive immunology (New York, N.Y. : 1989) 1999;41(3):174-82.
1999: Timothy Doherty; R L Coffman
Ability of macrophage subsets to transfer resistance to murine leishmaniasis is dependent on IL-12 production.
European journal of immunology 1999;29(2):522-9.
1998: Sharon M Wahl; Teresa Greenwell-Wild; Gang Peng; Hollie Hale-Donze; Timothy Doherty; Diane Mizel; Jan M Orenstein
Mycobacterium avium complex augments macrophage HIV-1 production and increases CCR5 expression.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12574-9.
1998: Timothy Doherty; Alan Sher; Stefanie N Vogel
Paclitaxel (Taxol)-induced killing of Leishmania major in murine macrophages.
Infection and immunity 1998;66(9):4553-6.
1998: Timothy Doherty; Alan Sher
IL-12 promotes drug-induced clearance of Mycobacterium avium infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5428-35.
1998: Alan Sher; R T Gazzinelli; Dragana Jankovic; TM Scharton-Kersten; George Yap; Timothy Doherty; T Wynn
Cytokines as determinants of disease and disease interactions.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1998;31(1):85-7.
1997: NA Giese; Lucia Gabriele; Timothy Doherty; D M Klinman; L Tadesse-Heath; C Contursi; S L Epstein; Herbert C Morse
Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression.
The Journal of experimental medicine 1997;186(9):1535-46.
1997: Timothy Doherty; Alan Sher
Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4822-31.
1997: Timothy Doherty; N Giese; Herbert C Morse; R L Coffman
Modulation of murine AIDS-related pathology by concurrent antibody treatment and coinfection with Leishmania major.
Journal of virology 1997;71(5):3702-9.
1996: Timothy Doherty; R L Coffman
Leishmania major: effect of infectious dose on T cell subset development in BALB/c mice.
Experimental parasitology 1996;84(2):124-35.
1996: R A Morawetz; Lucia Gabriele; Luiz Vicente Rizzo; N Noben-Trauth; R Kühn; K Rajewsky; Werner Muller; Timothy Doherty; F Finkelman; R L Coffman; Herbert C Morse
Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.
The Journal of experimental medicine 1996;184(5):1651-61.
1996: Timothy Doherty; R A Seder; Alan Sher
Induction and regulation of IL-15 expression in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):735-41.
1995: Timothy Doherty
T-cell regulation of macrophage function.
Current opinion in immunology 1995;7(3):400-4.
1995: Timothy Doherty; Herbert C Morse; Robert L Coffman
Modulation of specific T cell responses by concurrent infection with Leishmania major and LP-BM5 murine leukemia viruses.
International immunology 1995;7(1):131-8.
1994: R A Morawetz; Timothy Doherty; N A Giese; Janet W Hartley; Werner Muller; R Kühn; K Rajewsky; R Coffman; Herbert C Morse
Resistance to murine acquired immunodeficiency syndrome (MAIDS)
Science (New York, N.Y.) 1994;265(5169):264-6; author reply 267.
1994: Timothy Doherty; S G Love; D R Harding; J D Watson
Reversal of T cell unresponsiveness by augmentation of antigen presenting cell function.
International immunology 1994;6(5):761-8.
1993: Timothy Doherty; Robert A Kastelein; Satish Menon; S Andrade; Robert L Coffman
Modulation of murine macrophage function by IL-13.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):7151-60.
1993: Timothy Doherty; Robert L Coffman
Leishmania antigens presented by GM-CSF-derived macrophages protect susceptible mice against challenge with Leishmania major.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(12):5476-83.
1993: Timothy Doherty; B T Bäckström; S G Love; D R Harding; J D Watson
Identification of T cell stimulatory epitopes from the 18 kDa protein of Mycobacterium leprae.
International immunology 1993;5(6):673-80.
1993: S E Macatonia; Timothy Doherty; S C Knight; Anne O'Garra
Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):3755-65.
1991: J D Watson; B T Backstrom; Timothy Doherty
New generation vaccines: does antibody play a directional role in antigen-processing?
The American journal of tropical medicine and hygiene 1991;44(4 Pt 2):28-33.
1991: Timothy Doherty; B T Bäckström; R L Prestidge; S G Love; D R Harding; J D Watson
Immune responses to the 18-kDa protein of Mycobacterium leprae. Similar B cell epitopes but different T cell epitopes seen by inbred strains of mice.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1934-40.
1989: Timothy Doherty; Roger J Booth; S G Love; J J Gibson; D R Harding; J D Watson
Characterization of an antibody-binding epitope from the 18-kDa protein on Mycobacterium leprae.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(5):1691-5.