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Cristina Casals

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Olga Cañadas; Cristina Casals
Differential scanning calorimetry of protein-lipid interactions.
Cristina Casals; Olga Cañadas
Role of lipid ordered/disordered phase coexistence in pulmonary surfactant function.
Christian A Ruge; Ulrich F Schaefer; Rolf Müller; Jesús Pérez-Gil; Olga Cañadas; Cristina Casals; Mercedes Echaide; Jennifer Herrmann; Julian Kirch; Claus-Michael Lehr
The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles.

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All Publications

2013: Olga Cañadas; Cristina Casals
Differential scanning calorimetry of protein-lipid interactions.
Methods in molecular biology (Clifton, N.J.) 2013;974():55-71.
2012: Cristina Casals; Olga Cañadas
Role of lipid ordered/disordered phase coexistence in pulmonary surfactant function.
Biochimica et biophysica acta 2012;1818(11):2550-62.
2012: Christian A Ruge; Ulrich F Schaefer; Rolf Müller; Jesús Pérez-Gil; Olga Cañadas; Cristina Casals; Mercedes Echaide; Jennifer Herrmann; Julian Kirch; Claus-Michael Lehr
The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles.
PloS one 2012;7(7):e40775.
2011: Christian A Ruge; Ulrich F Schaefer; Marc Schneider; Jesus Perez-Gil; Olga Cañadas; Cristina Casals; Julian Kirch; Claus-Michael Lehr
Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A.
Nanomedicine : nanotechnology, biology, and medicine 2011;7(6):690-3.
2011: Alejandra Sáenz; L Alvarez; M Santos; A López-Sánchez; J L Castillo-Olivares; Andrés Varela; R Segal; Cristina Casals
Beneficial effects of synthetic KL₄ surfactant in experimental lung transplantation.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;37(4):925-32.
2011: Olga Cañadas; Kevin M W Keough; Cristina Casals
Bacterial lipopolysaccharide promotes destabilization of lung surfactant-like films.
Biophysical journal 2011;100(1):108-16.
2010: Alejandra Sáenz; Almudena López-Sánchez; Jonás Mojica-Lázaro; Leticia Martínez-Caro; Nicolas Nin; Luis A Bagatolli; Cristina Casals
Fluidizing effects of C-reactive protein on lung surfactant membranes: protective role of surfactant protein A.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):3662-73.
2009: Jorge Vera; Rafael Fenutría; Olga Cañadas; Maite Figueras; Rubén Mota-Blanco; Maria-Rosa Sarrias; David L Williams; Cristina Casals; José Yelamos; Francisco Lozano
The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1506-11.
2008: Olga Cañadas; Ignacio García-Verdugo; Kevin M W Keough; Cristina Casals
SP-A permeabilizes lipopolysaccharide membranes by forming protein aggregates that extract lipids from the membrane.
Biophysical journal 2008;95(7):3287-94.
2008: Cristina Casals; Hanna Johansson; Alejandra Saenz; Magnus Gustafsson; Carlos Alfonso; Kerstin Nordling; Jan Johansson
C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C - structural features and membrane interactions.
The FEBS journal 2008;275(3):536-47.
2007: Ignacio García-Verdugo; Olga Cañadas; Svetla G Taneva; Kevin M W Keough; Cristina Casals
Surfactant protein A forms extensive lattice-like structures on 1,2-dipalmitoylphosphatidylcholine/rough-lipopolysaccharide-mixed monolayers.
Biophysical journal 2007;93(10):3529-40.
2007: Fernando Sánchez-Barbero; Germán Rivas; Wolfram Steinhilber; Cristina Casals
Structural and functional differences among human surfactant proteins SP-A1, SP-A2 and co-expressed SP-A1/SP-A2: role of supratrimeric oligomerization.
The Biochemical journal 2007;406(3):479-89.
2007: Maria-Rosa Sarrias; Montse Farnós; Rubén Mota-Blanco; Fernando Sánchez-Barbero; Anna Ibáñez; Idoia Gimferrer; Jorge Vera; Rafael Fenutría; Cristina Casals; José Yélamos; Francisco Lozano
CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11724-9.
2007: Alejandra Sáenz; Olga Cañadas; Luís A Bagatolli; Fernando Sánchez-Barbero; Mark E Johnson; Cristina Casals
Effect of surfactant protein A on the physical properties and surface activity of KL4-surfactant.
Biophysical journal 2007;92(2):482-92.
2006: Alejandra Sáenz; Olga Cañadas; Luís A Bagatolli; Mark E Johnson; Cristina Casals
Physical properties and surface activity of surfactant-like membranes containing the cationic and hydrophobic peptide KL4.
The FEBS journal 2006;273(11):2515-27.
2005: Maria-Rosa Sarrias; Sandra Roselló; Fernando Sánchez-Barbero; Josep M Sierra; Jordi Vila; José Yélamos; Jordi Vives; Cristina Casals; Francisco Lozano
A role for human Sp alpha as a pattern recognition receptor.
The Journal of biological chemistry 2005;280(42):35391-8.
2005: Ignacio García-Verdugo; Fernando Sánchez-Barbero; Katrin Soldau; Peter S Tobias; Cristina Casals
Interaction of SP-A (surfactant protein A) with bacterial rough lipopolysaccharide (Re-LPS), and effects of SP-A on the binding of Re-LPS to CD14 and LPS-binding protein.
The Biochemical journal 2005;391(Pt 1):115-24.
2005: Olga Cañadas; Alejandra Sáenz; Guillermo Orellana; Cristina Casals
Equilibrium studies of a fluorescent tacrolimus binding to surfactant protein A.
Analytical biochemistry 2005;340(1):57-65.
2005: Fernando Sánchez-Barbero; Jochen Strassner; Rafael García-Cañero; Wolfram Steinhilber; Cristina Casals
Role of the degree of oligomerization in the structure and function of human surfactant protein A.
The Journal of biological chemistry 2005;280(9):7659-70.
2004: Olga Cañadas; Rosa Guerrero; Rafael García-Cañero; Guillermo Orellana; Margarita Menéndez; Cristina Casals
Characterization of liposomal tacrolimus in lung surfactant-like phospholipids and evaluation of its immunosuppressive activity.
Biochemistry 2004;43(30):9926-38.
2004: Martha Vargas; Joaquim Gascon; Cristina Casals; David Schellenberg; Honorathy Urassa; Elizeus Kahigwa; Joaquin Ruiz; Jordi Vila
Etiology of diarrhea in children less than five years of age in Ifakara, Tanzania.
The American journal of tropical medicine and hygiene 2004;70(5):536-9.
2004: Fernando Valiño; Cristina Casals; Rosa Guerrero; Lourdes Alvarez; Martín Santos; Alejandra Sáenz; Andrés Varela; Miguel A Claro; Francisco J Tendillo; José Luis Castillo-Olivares
Inhaled nitric oxide affects endogenous surfactant in experimental lung transplantation.
Transplantation 2004;77(6):812-8.
2003: Joaquin Ruiz; Margarita M Navia; Cristina Casals; Josep M Sierra; M Teresa Jiménez de Anta; Jordi Vila
Integron-mediated antibiotic multiresistance in Acinetobacter baumannii clinical isolates from Spain.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2003;9(9):907-11.
2003: Ignacio García-Verdugo; Fernando Sánchez-Barbero; FU Bosch; Wolfram Steinhilber; Cristina Casals
Effect of hydroxylation and N187-linked glycosylation on molecular and functional properties of recombinant human surfactant protein A.
Biochemistry 2003;42(32):9532-42.
2003: Cristina Casals; Javier Arias-Diaz; Fernando Valino; Alejandra Saenz; Cruz Garcia; Jose L Balibrea; Elena Vara
Surfactant strengthens the inhibitory effect of C-reactive protein on human lung macrophage cytokine release.
American journal of physiology. Lung cellular and molecular physiology 2003;284(3):L466-72.
2002: Ignacio García-Verdugo; G Wang; J Floros; Cristina Casals
Structural analysis and lipid-binding properties of recombinant human surfactant protein a derived from one or both genes.
Biochemistry 2002;41(47):14041-53.
2001: Inés Plasencia; Antonio Cruz; Cristina Casals; Jesús Pérez-Gil
Superficial disposition of the N-terminal region of the surfactant protein SP-C and the absence of specific SP-B-SP-C interactions in phospholipid bilayers.
The Biochemical journal 2001;359(Pt 3):651-9.
2001: Inés Plasencia; Antonio Cruz; J L López-Lacomba; Cristina Casals; Jesús Pérez-Gil
Selective labeling of pulmonary surfactant protein SP-C in organic solution.
Analytical biochemistry 2001;296(1):49-56.
2001: Cristina Casals
Role of surfactant protein A (SP-A)/lipid interactions for SP-A functions in the lung.
Pediatric pathology & molecular medicine 2001;20(4):249-68.
2001: José M Oviedo; Fernando Valiño; Inés Plasencia; Alicia G Serrano; Cristina Casals; Jesús Pérez-Gil
Quantitation of pulmonary surfactant protein SP-B in the absence or presence of phospholipids by enzyme-linked immunosorbent assay.
Analytical biochemistry 2001;293(1):78-87.
2001: Inés Plasencia; L Rivas; Cristina Casals; Kevin M W Keough; Jesús Pérez-Gil
Intrinsic structural differences in the N-terminal segment of pulmonary surfactant protein SP-C from different species.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2001;129(1):129-39.
2001: José M Oviedo; Cristina Casals; Jesús Pérez-Gil
Pulmonary surfactant protein SP-B is significantly more immunoreactive in anionic than in zwitterionic bilayers.
FEBS letters 2001;494(3):236-40.
2001: Camilo J Acosta; Claudia M Galindo; J Kimario; K Senkoro; Honorathy Urassa; Cristina Casals; M Corachán; N Eseko; Marcel Tanner; Hassan Mshinda; Fred Lwilla; J Vila; Pedro L Alonso
Cholera outbreak in southern Tanzania: risk factors and patterns of transmission.
Emerging infectious diseases 2001;7(3 Suppl):583-7.
2000: Joaquim Gascón; Martha Vargas; David Schellenberg; Honorathy Urassa; Cristina Casals; Elizeus Kahigwa; John J Aponte; Hassan Mshinda; Jordi Vila
Diarrhea in children under 5 years of age from Ifakara, Tanzania: a case-control study.
Journal of clinical microbiology 2000;38(12):4459-62.
2000: LA Worthman; Kaushik Nag; N Rich; ML Ruano; Cristina Casals; Jesús Pérez-Gil; Kevin M W Keough
Pulmonary surfactant protein A interacts with gel-like regions in monolayers of pulmonary surfactant lipid extract.
Biophysical journal 2000;79(5):2657-66.
2000: Javier Arias-Diaz; I Garcia-Verdugo; Cristina Casals; N Sanchez-Rico; Elena Vara; Jose L Balibrea
Effect of surfactant protein A (SP-A) on the production of cytokines by human pulmonary macrophages.
Shock (Augusta, Ga.) 2000;14(3):300-6.
2000: ML Ruano; Ignacio García-Verdugo; E Miguel; Jesús Pérez-Gil; Cristina Casals
Self-aggregation of surfactant protein A.
Biochemistry 2000;39(21):6529-37.
2000: Antonio Cruz; LA Worthman; Alicia G Serrano; Cristina Casals; Kevin M W Keough; Jesús Pérez-Gil
Microstructure and dynamic surface properties of surfactant protein SP-B/dipalmitoylphosphatidylcholine interfacial films spread from lipid-protein bilayers.
European biophysics journal : EBJ 2000;29(3):204-13.
1999: Jordi Vila; Martha Vargas; Cristina Casals; Honorathy Urassa; Hassan Mshinda; D Schellemberg; Joaquim Gascon
Antimicrobial resistance of diarrheagenic Escherichia coli isolated from children under the age of 5 years from Ifakara, Tanzania.
Antimicrobial agents and chemotherapy 1999;43(12):3022-4.
1999: ML Ruano; Kaushik Nag; Cristina Casals; Jesús Pérez-Gil; Kevin M W Keough
Interactions of pulmonary surfactant protein A with phospholipid monolayers change with pH.
Biophysical journal 1999;77(3):1469-76.
1998: Antonio Cruz; Cristina Casals; Inés Plasencia; D Marsh; Jesús Pérez-Gil
Depth profiles of pulmonary surfactant protein B in phosphatidylcholine bilayers, studied by fluorescence and electron spin resonance spectroscopy.
Biochemistry 1998;37(26):9488-96.
1998: ML Ruano; Jesús Pérez-Gil; Cristina Casals
Effect of acidic pH on the structure and lipid binding properties of porcine surfactant protein A. Potential role of acidification along its exocytic pathway.
The Journal of biological chemistry 1998;273(24):15183-91.
1998: Kaushik Nag; Jesus Perez-Gil; ML Ruano; LA Worthman; June Stewart; Cristina Casals; Kevin M W Keough
Phase transitions in films of lung surfactant at the air-water interface.
Biophysical journal 1998;74(6):2983-95.
1998: ML Ruano; Kaushik Nag; LA Worthman; Cristina Casals; Jesús Pérez-Gil; Kevin M W Keough
Differential partitioning of pulmonary surfactant protein SP-A into regions of monolayers of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylcholine/dipalmitoylphosphatidylglycerol.
Biophysical journal 1998;74(3):1101-9.
1998: Cristina Casals; Andrés Varela; ML Ruano; Fernando Valiño; Jesús Pérez-Gil; N Torre; Eduardo Jorge; Francisco J Tendillo; José Luis Castillo-Olivares
Increase of C-reactive protein and decrease of surfactant protein A in surfactant after lung transplantation.
American journal of respiratory and critical care medicine 1998;157(1):43-9.
1997: A Cruz; Cristina Casals; Kevin M W Keough; Jesús Pérez-Gil
Different modes of interaction of pulmonary surfactant protein SP-B in phosphatidylcholine bilayers.
The Biochemical journal 1997;327 ( Pt 1)():133-8.
1997: Carme Font; Cristina Casals; T Kaifi; Elisabeth Coll; J Cid; J Villalta; Josep M Grau
Constitutional syndrome and lumbar pain.
Postgraduate medical journal 1997;73(863):599-601.
1997: Josep Mensa; Manel Almela; Cristina Casals; José Antonio Martínez; Francesc Marco; R Tomás; F Vidal; Eladio Soriano; T Jiménez de Anta
[Yield of blood cultures in relation to the cultured blood volume in Bactec 6A bottles].
Medicina clínica 1997;108(14):521-3.
1997: J A Martínez; J Mensa; F Marco; Manel Almela; J Lopez; Cristina Casals; E Soriano; M Teresa Jiménez de Anta
Risk factors for oxacillin/methicillin resistance in coagulase-negative staphylococci.
The Journal of hospital infection 1997;35(4):295-9.
1996: F Vidal; J Mensa; Manel Almela; J A Martínez; Francesc Marco; Cristina Casals; José M Gatell; Eladio Soriano; M Teresa Jimenez De Anta
Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment. Analysis of 189 episodes.
Archives of internal medicine 1996;156(18):2121-6.
1996: ML Ruano; E Miguel; Jesus Perez-Gil; Cristina Casals
Comparison of lipid aggregation and self-aggregation activities of pulmonary surfactant-associated protein A.
The Biochemical journal 1996;313 ( Pt 2)():683-9.
1995: Jesús Pérez-Gil; Cristina Casals; D Marsh
Interactions of hydrophobic lung surfactant proteins SP-B and SP-C with dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol bilayers studied by electron spin resonance spectroscopy.
Biochemistry 1995;34(12):3964-71.
1995: Cristina Casals; Manel Almela; Francesc Marco; P Sort
[Pasteurella pneumotropica sepsis].
Medicina clínica 1995;104(9):358-9.
1995: A Cruz; Cristina Casals; Jesus Perez-Gil
Conformational flexibility of pulmonary surfactant proteins SP-B and SP-C, studied in aqueous organic solvents.
Biochimica et biophysica acta 1995;1255(1):68-76.
1994: Jesús Pérez-Gil; J L López-Lacomba; A Cruz; A Beldarraín; Cristina Casals
Deacylated pulmonary surfactant protein SP-C has different effects on the thermotropic behaviour of bilayers of dipalmitoylphosphatidyl-glycerol (DPPG) than the native acylated protein.
Biochemical Society transactions 1994;22(3):372S.
1994: Cristina Casals; ML Ruano; E Miguel; P Sanchez; Jesus Perez-Gil
Surfactant protein-C enhances lipid aggregation activity of surfactant protein-A.
Biochemical Society transactions 1994;22(3):370S.
1993: Cristina Casals; E Miguel; Jesus Perez-Gil
Tryptophan fluorescence study on the interaction of pulmonary surfactant protein A with phospholipid vesicles.
The Biochemical journal 1993;296 ( Pt 3)():585-93.
1993: Jesús Pérez-Gil; A Cruz; Cristina Casals
Solubility of hydrophobic surfactant proteins in organic solvent/water mixtures. Structural studies on SP-B and SP-C in aqueous organic solvents and lipids.
Biochimica et biophysica acta 1993;1168(3):261-70.
1990: Cristina Casals; L Herrera; P Garcia-Barreno; A M Municio
Association of changes in lysophosphatidylcholine metabolism and in microsomal membrane lipid composition to the pulmonary injury induced by oleic acid.
Biochimica et biophysica acta 1990;1023(2):290-7.
1989: Cristina Casals; L Herrera; María Gasset; P Garcia-Barreno; A M Municio
Microsomal membrane fluidity and phosphatidylcholine synthesis in rabbit lung under high oxygen tension.
Cell biochemistry and function 1989;7(3):193-9.
1989: Cristina Casals; L Herrera; E Miguel; P Garcia-Barreno; A M Municio
Comparison between intra- and extracellular surfactant in respiratory distress induced by oleic acid.
Biochimica et biophysica acta 1989;1003(2):201-3.
1987: Cristina Casals; María Gasset; M C Méndez; P García-Barreno; A M Municio
Lipid alterations in liver and kidney induced by normobaric hyperoxia: correlations with changes in microsomal membrane fluidity.
Biochemical medicine and metabolic biology 1987;37(3):269-81.
1986: Cristina Casals; L Herrera; María Gasset; P García-Barreno; A M Municio
Glycerolipid metabolism in lung from ventilated and unventilated rabbits.
Biochemistry international 1986;12(5):757-66.
1985: Cristina Casals; L M Herrero; Y Soriano; P García-Barreno; A M Municio
Membrane regulation of liver and lung microsomes under low oxygen tension.
Biochemical and biophysical research communications 1985;126(1):551-8.
1984: Cristina Casals; Carmen Acebal; Jesús Pérez-Gil; R Arche
Effect of lipids on activity and conformation of lysolecithin:lysolecithin acyltransferase from rabbit lung.
Molecular and cellular biochemistry 1984;63(1):13-20.
1984: R Arche; Carmen Acebal; Cristina Casals; P Estrada; L Herrera
Lysolecithin:lysolecithin acyltransferase from rabbit lung. A conformational study.
International journal of peptide and protein research 1984;23(5):487-93.
1984: P Estrada; Carmen Acebal; C Bauluz; Cristina Casals; R Arche
Influence of temperature on stability and activity of lysolecithin acyltransferase and acyl-CoA hydrolase from rabbit lung.
Biochemistry international 1984;8(3):339-46.
1984: Cristina Casals; Carmen Acebal; R Arche
Substrate selectivity of lysophosphatidylcholine: lysophosphatidylcholine acyltransferase from rabbit lung.
The International journal of biochemistry 1984;16(7):773-8.
1983: Cristina Casals; P Garcia-Barreno; A M Municio
Lipogenesis in liver, lung and adipose tissue of rats fed with oleoylanilide.
The Biochemical journal 1983;212(2):339-44.
1982: Cristina Casals; Carmen Acebal; M Cruz-Alvarez; P Estrada; R Arche
Lysolecithin:lysolecithin acyltransferase from rabbit lung: enzymatic properties and kinetic study.
Archives of biochemistry and biophysics 1982;217(2):422-33.