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Peter Linsley

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Aimee Jackson; Peter Linsley
The therapeutic potential of microRNA modulation.
Peter Linsley; Aimee L Jackson
Hidden reach of the micromanagers.
Aimee L Jackson; Peter Linsley
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application.

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All Publications

2010: Aimee Jackson; Peter Linsley
The therapeutic potential of microRNA modulation.
Discovery medicine 2010;9(47):311-8.
2010: Peter Linsley; Aimee L Jackson
Hidden reach of the micromanagers.
BMC biology 2010;8():53.
2010: Aimee L Jackson; Peter Linsley
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application.
Nature reviews. Drug discovery 2010;9(1):57-67.
2009: Timothy A Vickers; Walt F Lima; Hongjiang Wu; Josh G Nichols; Peter Linsley; Stanley T Crooke
Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.
Nucleic acids research 2009;37(20):6927-41.
2009: Chin-Hsing Lin; Aimee L Jackson; Jie Guo; Peter Linsley; Robert N Eisenman
Myc-regulated microRNAs attenuate embryonic stem cell differentiation.
The EMBO journal 2009;28(20):3157-70.
2009: Zhan Zhang; Hong Sun; Hongyue Dai; Ryan M Walsh; Maki Imakura; Janell Schelter; Julja Burchard; Xudong Dai; Aaron N Chang; Robert L Diaz; Joseph R Marszalek; Steven R Bartz; Michael Carleton; Michele A Cleary; Peter Linsley; Carla Grandori
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT.
Cell cycle (Georgetown, Tex.) 2009;8(17):2756-68.
2009: Peter Linsley; Steven G Nadler
The clinical utility of inhibiting CD28-mediated costimulation.
Immunological reviews 2009;229(1):307-21.
2009: Peter Linsley; Edward A Clark; Jeffrey A Ledbetter
Pillars article: T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. 1990. Proc. Natl. Acad. Sci. USA 87: 5031-5035.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2559-63.
2009: B Nelson Chau; Robert L Diaz; Matthew A Saunders; Chun Cheng; Aaron N Chang; Paul Warrener; Jeffrey Bradshaw; Peter Linsley; Michele A Cleary
Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.
Cancer research 2009;69(4):1368-74.
2009: Julja Burchard; Aimee L Jackson; Vladislav Malkov; Rachel H V Needham; Yejun Tan; Steven R Bartz; Hongyue Dai; Alan B Sachs; Peter Linsley
MicroRNA-like off-target transcript regulation by siRNAs is species specific.
RNA (New York, N.Y.) 2009;15(2):308-15.
2008: Sara A Georges; Matthew C Biery; Soo-Yeon Kim; Janell M Schelter; Jane Guo; Aaron N Chang; Aimee L Jackson; Michael O Carleton; Peter Linsley; Michele A Cleary; B Nelson Chau
Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215.
Cancer research 2008;68(24):10105-12.
2008: Galina Gabriely; Thomas Wurdinger; Santosh kesari; Christine C Esau; Julja Burchard; Peter Linsley; Anna M Krichevsky
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.
Molecular and cellular biology 2008;28(17):5369-80.
2008: Irena Ivanovska; Alexey S Ball; Robert L Diaz; Jill F Magnus; Miho Kibukawa; Janell M Schelter; Sumire V Kobayashi; Lee Lim; Julja Burchard; Aimee L Jackson; Peter Linsley; Michele A Cleary
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
Molecular and cellular biology 2008;28(7):2167-74.
2008: Namjin Chung; Xiaohua Douglas Zhang; Anthony Kreamer; Louis Locco; Pei-Fen Kuan; Steven Bartz; Peter Linsley; Marc Ferrer; Berta Strulovici
Median absolute deviation to improve hit selection for genome-scale RNAi screens.
Journal of biomolecular screening 2008;13(2):149-58.
2008: Namjin Chung; Louis Locco; Kevin W Huff; Steven Bartz; Peter Linsley; Marc Ferrer; Berta Strulovici
An efficient and fully automated high-throughput transfection method for genome-scale siRNA screens.
Journal of biomolecular screening 2008;13(2):142-8.
2008: Richard A Klinghoffer; Brian Roberts; James Annis; Jason Frazier; Patrick Lewis; Peter Linsley; Michele A Cleary
An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity.
Assay and drug development technologies 2008;6(1):105-19.
2008: Aimee L Jackson; Mao Mao; Sumire Kobayashi; Teresa Ward; Matthew Biery; Hongyue Dai; Steven R Bartz; Peter Linsley
Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor.
Cancer informatics 2008;6():147-64.
2007: Lee P Lim; Peter Linsley
Mustering the micromanagers.
Nature biotechnology 2007;25(9):996-7.
2007: Michael Carleton; Michele A Cleary; Peter Linsley
MicroRNAs and cell cycle regulation.
Cell cycle (Georgetown, Tex.) 2007;6(17):2127-32.
2007: Lin He; Xingyue He; Lee P Lim; Elisa de Stanchina; Zhenyu Xuan; Yu Liang; Wen Xue; Lars Zender; Jill Magnus; Dana Ridzon; Aimee L Jackson; Peter Linsley; Caifu Chen; Scott W Lowe; Michele A Cleary; Gregory J Hannon
A microRNA component of the p53 tumour suppressor network.
Nature 2007;447(7148):1130-4.
2007: Ralf Kittler; Vineeth Surendranath; Anne-Kristin Heninger; Mikolaj Slabicki; Mirko Theis; Gabriele Putz; Kristin Franke; Antonio Caldarelli; Hannes Grabner; Karol Kozak; Jan Wagner; Effi Rees; Bernd Korn; Corina Frenzel; Christoph Sachse; Birte soennichsen; Jie Guo; Janell Schelter; Julja Burchard; Peter Linsley; Aimee L Jackson; Bianca Habermann; Frank Buchholz
Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies.
Nature methods 2007;4(4):337-44.
2007: Xudong Dai; Angus T De Souza; Hongyue Dai; David L Lewis; Chang-kyu Lee; Andy G Spencer; Hans Herweijer; James E Hagstrom; Peter Linsley; Douglas E Bassett; Roger G Ulrich; Yudong D He
PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy.
PLoS computational biology 2007;3(3):e30.
2007: Peter Linsley; Janell Schelter; Julja Burchard; Miho Kibukawa; Melissa M Martin; Steven Bartz; Jason Johnson; Jordan M Cummins; Christopher K Raymond; Hongyue Dai; Nelson Chau; Michele Cleary; Aimee L Jackson; Michael Carleton; Lee Lim
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression.
Molecular and cellular biology 2007;27(6):2240-52.
2006: Steven Bartz; Zhan Zhang; Julja Burchard; Maki Imakura; Melissa Martin; Anthony Palmieri; Rachel Needham; Jie Guo; Marcia Gordon; Namjin Chung; Paul Warrener; Aimee L Jackson; Michael Carleton; Melissa Oatley; Louis Locco; Francesca Santini; Todd Smith; Priya Kunapuli; Marc Ferrer; Berta Strulovici; Stephen H Friend; Peter Linsley
Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.
Molecular and cellular biology 2006;26(24):9377-86.
2006: Amy S Espeseth; Qian Huang; Adam Gates; Min Xu; Yuanjiang Yu; Adam J Simon; Xiao-Ping Shi; Xiaohua Zhang; Paul Hodor; David J Stone; Julja Burchard; Guy Cavet; Steven Bartz; Peter Linsley; William Ray; Daria J Hazuda
A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels.
Molecular and cellular neurosciences 2006;33(3):227-35.
2006: Christophe Echeverri; Philip A Beachy; Buzz Baum; Michael Boutros; Frank Buchholz; Sumit K Chanda; Julian Downward; Jan Ellenberg; Andrew G Fraser; Nir Hacohen; William C Hahn; Aimee L Jackson; Amy Kiger; Peter Linsley; Lawrence Lum; Yong Ma; Bernard Mathey-Prévôt; David E Root; David M Sabatini; Jussi Taipale; Norbert Perrimon; René Bernards
Minimizing the risk of reporting false positives in large-scale RNAi screens.
Nature methods 2006;3(10):777-9.
2006: Dianne S Schwarz; Hongliu Ding; Lori Kennington; Jessica T Moore; Janell Schelter; Julja Burchard; Peter Linsley; Neil Aronin; Zuoshang Xu; Phillip D Zamore
Designing siRNA that distinguish between genes that differ by a single nucleotide.
PLoS genetics 2006;2(9):e140.
2006: Aimee L Jackson; Julja Burchard; Devin Leake; Angela Reynolds; Janell Schelter; Jie Guo; Jason Johnson; Lee Lim; Jon Karpilow; Kim Nichols; William Marshall; Anastasia Khvorova; Peter Linsley
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing.
RNA (New York, N.Y.) 2006;12(7):1197-205.
2006: Aimee L Jackson; Julja Burchard; Janell Schelter; B Nelson Chau; Michele Cleary; Lee Lim; Peter Linsley
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.
RNA (New York, N.Y.) 2006;12(7):1179-87.
2006: Michael Carleton; Mao Mao; Matthew Biery; Paul Warrener; Sammy Kim; Carolyn Buser; C Gary Marshall; Christine Fernandes; James Annis; Peter Linsley
RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure.
Molecular and cellular biology 2006;26(10):3853-63.
2006: Jerald P Radich; Hongyue Dai; Mao Mao; Vivian G Oehler; Janell Schelter; Brian J Druker; Charles L Sawyers; Neil Shah; Wendy Stock; Cheryl L Willman; Stephen H Friend; Peter Linsley
Gene expression changes associated with progression and response in chronic myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2794-9.
2006: Angus T De Souza; Xudong Dai; Andrew G Spencer; Tom Reppen; Ann Menzie; Paula L Roesch; Yudong He; Michelle J Caguyong; Sherri Bloomer; Hans Herweijer; Jon A Wolff; James E Hagstrom; David L Lewis; Peter Linsley; Roger G Ulrich
Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice.
Nucleic acids research 2006;34(16):4486-94.
2005: Richard V Parry; Jens M Chemnitz; Kenneth A Frauwirth; Anthony R Lanfranco; Inbal Braunstein; Sumire V Kobayashi; Peter Linsley; Craig Thompson; James L Riley
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms.
Molecular and cellular biology 2005;25(21):9543-53.
2005: Peter Linsley
New look at an old costimulator.
Nature immunology 2005;6(3):231-2.
2005: Christian P Larsen; Thomas C Pearson; Andrew B Adams; Paul Tso; Nozomu Shirasugi; Elizabeth Strobert; Dan Anderson; Shannon Cowan; Karen Price; Joseph Naemura; John Emswiler; JoAnne Greene; Lori Ann Turk; Jurgen Bajorath; Robert Townsend; David Hagerty; Peter Linsley; Robert Peach
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(3):443-53.
2005: Lee P Lim; Nelson C Lau; Philip Garrett-Engele; Andrew Grimson; Janell Schelter; John Castle; David P Bartel; Peter Linsley; Jason Johnson
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs.
Nature 2005;433(7027):769-73.
2005: Despina Siolas; Cara Lerner; Julja Burchard; Wei Ge; Peter Linsley; Patrick J Paddison; Gregory J Hannon; Michele A Cleary
Synthetic shRNAs as potent RNAi triggers.
Nature biotechnology 2005;23(2):227-31.
2004: Michele A Cleary; Kristopher Kilian; Yanqun Wang; Jeff Bradshaw; Guy Cavet; Wei Ge; Amit Kulkarni; Patrick J Paddison; Kenneth Chang; Nihar Sheth; Eric Leproust; Ernest M Coffey; Julja Burchard; W Richard McCombie; Peter Linsley; Gregory J Hannon
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis.
Nature methods 2004;1(3):241-8.
2004: Aimee L Jackson; Peter Linsley
Noise amidst the silence: off-target effects of siRNAs?
Trends in genetics : TIG 2004;20(11):521-4.
2004: Mao Mao; Matt Biery; Sumire V Kobayashi; Terry Ward; Greg Schimmack; Julja Burchard; Janell Schelter; Hongyue Dai; Yudong D He; Peter Linsley
T lymphocyte activation gene identification by coregulated expression on DNA microarrays.
Genomics 2004;83(6):989-99.
2004: Jerald P Radich; Mao Mao; Sergey B Stepaniants; Matt Biery; John Castle; Terry Ward; Greg Schimmack; Sumire Kobayashi; Michael Carleton; Johanna Lampe; Peter Linsley
Individual-specific variation of gene expression in peripheral blood leukocytes.
Genomics 2004;83(6):980-8.
2004: Katrien Berns; E Marielle Hijmans; Jasper Mullenders; Thijn R Brummelkamp; Arno Velds; Mike Heimerikx; Ron Kerkhoven; Mandy Madiredjo; Wouter Nijkamp; Britta Weigelt; Reuven Agami; Wei Ge; Guy Cavet; Peter Linsley; Roderick L Beijersbergen; René Bernards
A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
Nature 2004;428(6981):431-7.
2004: Johanna W Lampe; Sergey B Stepaniants; Mao Mao; Jerald P Radich; Hongyue Dai; Peter Linsley; Stephen H Friend; John D Potter
Signatures of environmental exposures using peripheral leukocyte gene expression: tobacco smoke.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(3):445-53.
2003: Aimee L Jackson; Steven Bartz; Janell Schelter; Sumire V Kobayashi; Julja Burchard; Mao Mao; Bin Li; Guy Cavet; Peter Linsley
Expression profiling reveals off-target gene regulation by RNAi.
Nature biotechnology 2003;21(6):635-7.
2003: Eric E Schadt; Stephanie A Monks; Thomas A Drake; Aldons J Lusis; Nam Che; Veronica V Colinayo; Thomas G Ruff; Stephen B Milligan; john lamb; Guy Cavet; Peter Linsley; Mao Mao; Roland B Stoughton; Stephen H Friend
Genetics of gene expression surveyed in maize, mouse and man.
Nature 2003;422(6929):297-302.
2002: James L Riley; Mao Mao; Sumire Kobayashi; Matt Biery; Julja Burchard; Guy Cavet; Brian P Gregson; Carl H June; Peter Linsley
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11790-5.
2002: Daniel D Shoemaker; Peter Linsley
Recent developments in DNA microarrays.
Current opinion in microbiology 2002;5(3):334-7.
2002: Laura J van 't Veer; Hongyue Dai; Marc J van de Vijver; Yudong D He; Augustinus A M Hart; Mao Mao; Hans L Peterse; Karin van der Kooy; Matthew J Marton; Anke T Witteveen; George J Schreiber; Ron Kerkhoven; Chris Roberts; Peter Linsley; René Bernards; Stephen H Friend
Gene expression profiling predicts clinical outcome of breast cancer.
Nature 2002;415(6871):530-6.
2001: Mercedes Pérez-Melgosa; Hans D Ochs; Peter Linsley; J D Laman; M van Meurs; Richard A Flavell; Robert Ernst; S I Miller; Christopher B Wilson
Carrier-mediated enhancement of cognate T cell help: the basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine.
European journal of immunology 2001;31(8):2373-81.
2001: Timothy R Hughes; Mao Mao; A R Jones; Julja Burchard; Matthew J Marton; K W Shannon; S M Lefkowitz; Ziman Michael; Janell Schelter; Michael R Meyer; Sumire V Kobayashi; C Davis; Hongyue Dai; Yudong D He; S B Stephaniants; Guy Cavet; W L Walker; A West; Ernest M Coffey; Daniel D Shoemaker; Roland B Stoughton; A P Blanchard; Stephen H Friend; Peter Linsley
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer.
Nature biotechnology 2001;19(4):342-7.
2001: D D Shoemaker; E E Schadt; C D Armour; Y D He; P Garrett-Engele; P D McDonagh; P M Loerch; A Leonardson; P Y Lum; Guy Cavet; L F Wu; S J Altschuler; Stephen Wilton Edwards; J King; J S Tsang; G Schimmack; J M Schelter; J Koch; Ziman Michael; M J Marton; B Li; P Cundiff; T Ward; J Castle; M Krolewski; M R Meyer; M Mao; J Burchard; M J Kidd; H Dai; J W Phillips; Peter Linsley; R Stoughton; S Scherer; M S Boguski
Experimental annotation of the human genome using microarray technology.
Nature 2001;409(6822):922-7.
2001: Peter Linsley
T cell activation: you can't get good help.
Nature immunology 2001;2(2):139-40.
2000: J R Abrams; S L Kelley; E Hayes; T Kikuchi; M J Brown; Sewon Kang; M G Lebwohl; Cynthia Guzzo; BV Jegasothy; Peter Linsley; J G Krueger
Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells.
The Journal of experimental medicine 2000;192(5):681-94.
2000: Eric Villegas; Ulrike Wille; Linden Craig; Peter Linsley; Donna Rennick; Robert Peach; Christopher A Hunter
Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice.
Infection and immunity 2000;68(5):2837-44.
2000: Cong Yu; Peter Linsley; K Seidel; George E Sale; H Joachim Deeg; Richard A Nash; Rainer Storb
Cytotoxic T lymphocyte antigen 4-immunoglobulin fusion protein combined with methotrexate/cyclosporine as graft-versus-host disease prevention in a canine dog leukocyte antigen-nonidentical marrow transplant model.
Transplantation 2000;69(3):450-4.
1999: J R Abrams; M G Lebwohl; Cynthia Guzzo; BV Jegasothy; Michael T Goldfarb; Bernard S Goffe; A Menter; N J Lowe; Gerald Krueger; M J Brown; R S Weiner; M J Birkhofer; G L Warner; KK Berry; Peter Linsley; J G Krueger; H D Ochs; S L Kelley; Sewon Kang
CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris.
The Journal of clinical investigation 1999;103(9):1243-52.
1998: M Niimi; Thomas C Pearson; Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Alejandro Aruffo; Peter Linsley; E Thomas; K Campbell; W C Fanslow; R S Geha; Peter J Morris; Kathryn J Wood
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5331-7.
1998: DA Mark; CE Donovan; George T De Sanctis; SJ Krinzman; Lester Kobzik; Peter Linsley; Mohamed H Sayegh; James A Lederer; David L Perkins; Patricia W Finn
Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.
International immunology 1998;10(11):1647-55.
1998: K Schlienger; K Uyemura; D Jullien; Peter Allan Sieling; Thomas H Rea; Peter Linsley; Robert L Modlin
B7-1, but not CD28, is crucial for the maintenance of the CD4+ T cell responses in human leprosy.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2407-13.
1998: C B Wilson; L J Embree; D Schowalter; R Albert; Alejandro Aruffo; Diane L Hollenbaugh; Peter Linsley; M A Kay
Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration.
Journal of virology 1998;72(9):7542-50.
1998: KR McIntosh; Peter Linsley; P A Bacha; Daniel B Drachman
Immunotherapy of experimental autoimmune myasthenia gravis: selective effects of CTLA4Ig and synergistic combination with an IL2-diphtheria toxin fusion protein.
Journal of neuroimmunology 1998;87(1-2):136-46.
1998: Eric T. Elwood; Christian P Larsen; Hong Rae Cho; Matthias Corbascio; S C Ritchie; DZ Alexander; Carol Tucker-Burden; Peter Linsley; Alejandro Aruffo; Diane L Hollenbaugh; K J Winn; Thomas C Pearson
Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.
Transplantation 1998;65(11):1422-8.
1998: MS Hayden; Peter Linsley; A R Wallace; H Marquardt; David E Kerr
Cloning, overexpression, and purification of cytosine deaminase from Saccharomyces cerevisiae.
Protein expression and purification 1998;12(2):173-84.
1998: Bogumila T Konieczny; Zhenhua Dai; Eric T. Elwood; S Saleem; Peter Linsley; Fady K Baddoura; Christian P Larsen; Thomas C Pearson; Fadi G Lakkis
IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2059-64.
1997: Hong Sun; Vladimir Subbotin; C Chen; Abdelouahab Aitouche; Luis A Valdivia; M H Sayegh; Peter Linsley; John J Fung; Thomas E Starzl; Abdul S Rao
Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody.
Transplantation 1997;64(12):1838-43.
1997: J D Bradshaw; P Lu; G Leytze; J Rodgers; Gary L Schieven; KL Bennett; Peter Linsley; S E Kurtz
Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation.
Biochemistry 1997;36(50):15975-82.
1997: P Lu; Y L Wang; Peter Linsley
Regulation of self-tolerance by CD80/CD86 interactions.
Current opinion in immunology 1997;9(6):858-62.
1997: Clay B Siegall; H G Haggerty; G L Warner; Dana F Chace; Bruce J Mixan; Peter Linsley; T Davidson
Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):5168-73.
1997: EB Samoilova; JL Horton; H Bassiri; Hongtao Zhang; Peter Linsley; Simon R Carding; Youhai Chen
B7 blockade prevents activation-induced cell death of thymocytes.
International immunology 1997;9(11):1663-8.
1997: L Gallon; Anil Chandraker; S Issazadeh; Robert Peach; Peter Linsley; Laurence A Turka; Mohamed H Sayegh; Samia J Khoury
Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4212-6.
1997: KL Bennett; J Bradshaw; T Youngman; J Rodgers; BW Greenfield; Alejandro Aruffo; Peter Linsley
Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain.
The Journal of biological chemistry 1997;272(43):26940-6.
1997: David I Daikh; barbara finck; Peter Linsley; Diane L Hollenbaugh; David Wofsy
Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3104-8.
1997: Collin J Weber; M K Hagler; J T Chryssochoos; Judith A Kapp; Gregory S Korbutt; Ray V Rajotte; Peter Linsley
CTLA4-Ig prolongs survival of microencapsulated neonatal porcine islet xenografts in diabetic NOD mice.
Cell transplantation 1997;6(5):505-8.
1997: K Onodera; Anil Chandraker; Meike Schaub; Thomas H W Stadlbauer; Stephan Korom; Robert Peach; Peter Linsley; Mohamed H Sayegh; JW Kupiec-Weglinski
CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1711-7.
1997: DB Schowalter; Leonard Meuse; Christopher B Wilson; Peter Linsley; Mark A Kay
Constitutive expression of murine CTLA4Ig from a recombinant adenovirus vector results in prolonged transgene expression.
Gene therapy 1997;4(8):853-60.
1997: Xin Xiao Zheng; Mohamed H Sayegh; X G Zheng; Yongsheng Li; Peter Linsley; Robert Peach; F Borriello; Terry B Strom; A H Sharpe; Laurence A Turka
The role of donor and recipient B7-1 (CD80) in allograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1169-73.
1997: William C Gause; V Mitro; Charles S Via; Peter Linsley; Joseph F Urban; RJ Greenwald
Do effector and memory T helper cells also need B7 ligand costimulatory signals?
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1055-8.
1997: William J Metzler; Jurgen Bajorath; WH Fenderson; S Y Shaw; Keith L Constantine; Joseph Naemura; G Leytze; Robert Peach; Thomas B Lavoie; L Mueller; Peter Linsley
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.
Nature structural biology 1997;4(7):527-31.
1997: Thomas C Pearson; DZ Alexander; Matthias Corbascio; Rose Hendrix; S C Ritchie; Peter Linsley; D Faherty; Christian P Larsen
Analysis of the B7 costimulatory pathway in allograft rejection.
Transplantation 1997;63(10):1463-9.
1997: AT Vella; T Mitchell; B Groth; Peter Linsley; J M Green; Craig Thompson; John W Kappler; Philippa Marrack
CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4714-20.
1997: RJ Greenwald; P Lu; MJ Halvorson; X Zhou; S Chen; Kathleen B Madden; P J Perrin; Suzanne C Morris; Fred D Finkelman; Robert Peach; Peter Linsley; Joseph F Urban; William C Gause
Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4088-96.
1997: Mark A Kay; Leonard Meuse; A M Gown; Peter Linsley; Diane L Hollenbaugh; Alejandro Aruffo; Hans D Ochs; Christopher B Wilson
Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4686-91.
1997: Jurgen Bajorath; William J Metzler; Peter Linsley
Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family.
Journal of molecular graphics & modelling 1997;15(2):135-9, 108-11.
1997: William C Gause; MJ Halvorson; P Lu; R Greenwald; Peter Linsley; Joseph F Urban; Fred D Finkelman
The function of costimulatory molecules and the development of IL-4-producing T cells.
Immunology today 1997;18(3):115-20.
1997: Fadi G Lakkis; Bogumila T Konieczny; S Saleem; Fady K Baddoura; Peter Linsley; DZ Alexander; R P Lowry; Thomas C Pearson; Christian P Larsen
Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2443-8.
1997: Christopher A Hunter; L Ellis-Neyer; KE Gabriel; M K Kennedy; K H Grabstein; Peter Linsley; Jack S Remington
The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2285-93.
1997: AM Keane-Myers; William C Gause; Peter Linsley; S J Chen; MARSHA WILLS-KARP
B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2042-9.
1997: E Graser; Kirsten Risch; Peter Linsley; W W Hancock; A Müller; Josef Brock; Petra Reinke; Jerzy W Kupiec-Weglinski; Hans-Dieter Volk; Manfred Lehmann
Synergism of CTLA4-IG and anti-CD4 monoclonal antibody treatment in a rat kidney transplant model.
Transplantation proceedings 1997;29(1-2):1307-9.
1997: S Ibrahim; FM Jakobs; Peter Linsley; Alfred P. Sanfilippo; William M Baldwin
CTLA4Ig inhibits alloantibody responses to transfusions and transplants.
Transplantation proceedings 1997;29(1-2):1025.
1997: N Harris; Robert Peach; Joseph Naemura; Peter Linsley; Graham Le Gros; franca ronchese
CD80 costimulation is essential for the induction of airway eosinophilia.
The Journal of experimental medicine 1997;185(1):177-82.
1996: S Ibrahim; FM Jakobs; Dilip S Kittur; Allan Hess; Peter Linsley; Alfred P. Sanfilippo; William M Baldwin
CTLA4Ig inhibits alloantibody responses to repeated blood transfusions.
Blood 1996;88(12):4594-600.
1996: K M Cabrian; K K Berry; W W Shuford; Robert S Mittler; J N Rodgers; Peter Linsley
Suppression of T-cell-dependent immune responses in monkeys by CTLA4Ig.
Transplantation proceedings 1996;28(6):3261-2.
1996: Wayne W Hancock; Mohamed H Sayegh; X G Zheng; R Peach; Peter Linsley; Laurence A Turka
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13967-72.
1996: N V Sherbina; Peter Linsley; S Myrdal; LS Grosmaire; Jeffrey A Ledbetter; G L Schieven
Intracellular CD22 rapidly moves to the cell surface in a tyrosine kinase-dependent manner following antigen receptor stimulation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4390-8.
1996: William C Gause; P Lu; X D Zhou; S J Chen; Kathleen B Madden; Suzanne C Morris; Peter Linsley; Fred D Finkelman; Joseph F Urban
H. polygyrus: B7-independence of the secondary type 2 response.
Experimental parasitology 1996;84(2):264-73.
1996: David H Wagner; James Hagman; Peter Linsley; W Hodsdon; J H Freed; M Karen Newell
Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2.
The Journal of experimental medicine 1996;184(5):1631-8.
1996: J L Greene; G M Leytze; John Emswiler; Robert Peach; J Bajorath; W Cosand; Peter Linsley
Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions.
The Journal of biological chemistry 1996;271(43):26762-71.
1996: JE Woodward; Lihui Qin; Kenneth D Chavin; J Lin; T Tono; Yaozhong Ding; Peter Linsley; Jonathan Bromberg; Prabhakar K Baliga
Blockade of multiple costimulatory receptors induces hyporesponsiveness: inhibition of CD2 plus CD28 pathways.
Transplantation 1996;62(7):1011-8.
1996: Samia J Khoury; L Gallon; R R Verburg; Anil Chandraker; Robert Peach; Peter Linsley; L A Turka; Wayne W Hancock; Mohamed H Sayegh
Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3700-5.
1996: MS Hayden; LS Grosmaire; N A Norris; L K Gilliland; G Winberg; D Tritschler; T T Tsu; Peter Linsley; Robert S Mittler; Peter D Senter; H P Fell; Jeffrey A Ledbetter
Costimulation by CD28 sFv expressed on the tumor cell surface or as a soluble bispecific molecule targeted to the L6 carcinoma antigen.
Tissue antigens 1996;48(4 Pt 1):242-54.
1996: Renu B Lal; Donna L Rudolph; Charlene S Dezzutti; Peter Linsley; H E Prince
Costimulatory effects of T cell proliferation during infection with human T lymphotropic virus types I and II are mediated through CD80 and CD86 ligands.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(3):1288-96.
1996: A Rehman; Y Tu; T Arima; Peter Linsley; M Wayne Flye
Long-term survival of rat to mouse cardiac xenografts with prolonged blockade of CD28-B7 interaction combined with peritransplant T-cell depletion.
Surgery 1996;120(2):205-12.
1996: M Inobe; N Aoki; Peter Linsley; J A Ledbetter; R Abe; M Murakami; T Uede
The role of the B7-1a molecule, an alternatively spliced form of murine B7-1 (CD80), on T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):582-8.
1996: Peter Linsley; J Bradshaw; J Greene; Robert Peach; KL Bennett; Robert S Mittler
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement.
Immunity 1996;4(6):535-43.
1996: Christian P Larsen; Eric T. Elwood; DZ Alexander; S C Ritchie; R Hendrix; Carol Tucker-Burden; H R Cho; Alejandro Aruffo; Diane L Hollenbaugh; Peter Linsley; K J Winn; Thomas C Pearson
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.
Nature 1996;381(6581):434-8.
1996: Thomas C Pearson; DZ Alexander; R Hendrix; Eric T. Elwood; Peter Linsley; K J Winn; Christian P Larsen
CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism.
Transplantation 1996;61(7):997-1004.
1996: Peter Linsley; P Golstein
Lymphocyte activation: T-cell regulation by CTLA-4.
Current biology : CB 1996;6(4):398-400.
1996: Collin J Weber; M K Hagler; J T Chryssochoos; Christian P Larsen; Thomas C Pearson; P Jensen; Judith A Kapp; Peter Linsley
CTLA4-Ig prolongs survival of microencapsulated rabbit islet xenografts in spontaneously diabetic Nod mice.
Transplantation proceedings 1996;28(2):821-3.
1996: N D Griggs; S S Agersborg; R J Noelle; J A Ledbetter; Peter Linsley; Kenneth S K Tung
The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells.
The Journal of experimental medicine 1996;183(3):801-10.
1995: Omar Haffar; M D Smithgall; J G Wong; J Bradshaw; Peter Linsley
Human immunodeficiency virus type 1 infection of CD4+ T cells down-regulates the expression of CD28: effect on T cell activation and cytokine production.
Clinical immunology and immunopathology 1995;77(3):262-70.
1995: Samia J Khoury; Enver Akalin; Anil Chandraker; Laurence A Turka; Peter Linsley; Mohamed H Sayegh; Wayne W Hancock
CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4521-4.
1995: Helios T Leung; J Bradshaw; Jeff Cleaveland; Peter Linsley
Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail.
The Journal of biological chemistry 1995;270(42):25107-14.
1995: Mark A Kay; Ai-Xuan Holterman; Leonard Meuse; Allen M Gown; Hans D Ochs; Peter Linsley; Christopher B Wilson
Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration.
Nature genetics 1995;11(2):191-7.
1995: Robert Peach; J Bajorath; J Naemura; G Leytze; J Greene; Alejandro Aruffo; Peter Linsley
Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
The Journal of biological chemistry 1995;270(36):21181-7.
1995: H M Kuiper; Mieke C Brouwer; Peter Linsley; René A W van Lier
Activated T cells can induce high levels of CTLA-4 expression on B cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1776-83.
1995: Peter Linsley
Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?
The Journal of experimental medicine 1995;182(2):289-92.
1995: M D Smithgall; J G Wong; Peter Linsley; Omar Haffar
Costimulation of CD4+ T cells via CD28 modulates human immunodeficiency virus type 1 infection and replication in vitro.
AIDS research and human retroviruses 1995;11(8):885-92.
1995: Peter Linsley; Steven G Nadler; J Bajorath; Robert Peach; Helios T Leung; J Rogers; J Bradshaw; M Stebbins; G Leytze; W Brady
Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules.
The Journal of biological chemistry 1995;270(25):15417-24.
1995: PM Wallace; J N Rodgers; G M Leytze; J S Johnson; Peter Linsley
Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):5885-95.
1995: Peter Linsley
The CD28/CTLA-4:B7 receptor system in experimental autoimmune encephalomyelitis.
The Journal of clinical investigation 1995;95(6):2429-30.
1995: Mohamed H Sayegh; Enver Akalin; Wayne W Hancock; Mary E Russell; Charles B Carpenter; Peter Linsley; Laurence A Turka
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.
The Journal of experimental medicine 1995;181(5):1869-74.
1995: Peter Linsley; Jeffrey A Ledbetter; Robert Peach; J Bajorath
CD28/CTLA-4 receptor structure, binding stoichiometry and aggregation during T-cell activation.
Research in immunology 1995;146(3):130-40.
1995: AT Vella; J E McCormack; Peter Linsley; John W Kappler; Philippa Marrack
Lipopolysaccharide interferes with the induction of peripheral T cell death.
Immunity 1995;2(3):261-70.
1995: P Lu; X D Zhou; S J Chen; Mark Moorman; A Schoneveld; S Morris; Fred D Finkelman; Peter Linsley; E Claassen; William C Gause
Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(3):1078-87.
1995: William C Gause; Joseph F Urban; Peter Linsley; P Lu
Role of B7 signaling in the differentiation of naive CD4+ T cells to effector interleukin-4-producing T helper cells.
Immunologic research 1995;14(3):176-88.
1995: Lewis L Lanier; S O'Fallon; C Somoza; Joseph H Phillips; Peter Linsley; K Okumura; D Ito; Miyuki Azuma
CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):97-105.
1994: G S Chatta; A G Spies; S Chang; Gregory J Mize; Peter Linsley; Jeffrey A Ledbetter; David R Morris
Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5393-401.
1994: A A Chahine; M Yu; M McKernan; Christian J Stoeckert; Peter Linsley; HENRY LAU
Local CTLA4Ig synergizes with one-dose anti-LFA-1 to achieve long-term acceptance of pancreatic islet allografts.
Transplantation proceedings 1994;26(6):3296.
1994: Mark Tepper; Peter Linsley; D Tritschler; J M Esselstyn
Tolerance induction by soluble CTLA4 in a mouse skin transplant model.
Transplantation proceedings 1994;26(6):3151-4.
1994: Robert Peach; J Bajorath; W Brady; G Leytze; J Greene; J Naemura; Peter Linsley
Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.
The Journal of experimental medicine 1994;180(6):2049-58.
1994: Peter Linsley; J L Greene; W Brady; J Bajorath; Jeffrey A Ledbetter; Robert Peach
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors.
Immunity 1994;1(9):793-801.
1994: J Bajorath; Robert Peach; Peter Linsley
Immunoglobulin fold characteristics of B7-1 (CD80) and B7-2 (CD86).
Protein science : a publication of the Protein Society 1994;3(11):2148-50.
1994: David B Corry; Steven L Reiner; Peter Linsley; Richard M Locksley
Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4142-8.
1994: S Wee; W C Wang; Andrew G Farr; A J Nelson; Dhavalkumar D Patel; Barton F Haynes; Peter Linsley; Alejandro Aruffo
Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues.
Cellular immunology 1994;158(2):353-64.
1994: M T Dietsch; P Y Chan; Steven B Kanner; L K Gilliland; Jeffrey A Ledbetter; Peter Linsley; Alejandro Aruffo
Coengagement of CD2 with LFA-1 or VLA-4 by bispecific ligand fusion proteins primes T cells to respond more effectively to T cell receptor-dependent signals.
Journal of leukocyte biology 1994;56(4):444-52.
1994: Jan C Simon; A Dietrich; V Mielke; C Wuttig; Wolfgang Vanscheidt; Peter Linsley; Erwin Schöpf; W Sterry
Expression of the B7/BB1 activation antigen and its ligand CD28 in T-cell-mediated skin diseases.
The Journal of investigative dermatology 1994;103(4):539-43.
1994: PM Wallace; J S Johnson; John F MacMaster; K A Kennedy; P Gladstone; Peter Linsley
CTLA4Ig treatment ameliorates the lethality of murine graft-versus-host disease across major histocompatibility complex barriers.
Transplantation 1994;58(5):602-10.
1994: barbara finck; Peter Linsley; David Wofsy
Treatment of murine lupus with CTLA4Ig.
Science (New York, N.Y.) 1994;265(5176):1225-7.
1994: P Lu; X Zhou; S J Chen; Mark Moorman; Suzanne C Morris; Fred D Finkelman; Peter Linsley; Joseph F Urban; William C Gause
CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite.
The Journal of experimental medicine 1994;180(2):693-8.
1994: Helios T Leung; Peter Linsley
The CD28 costimulatory pathway.
Therapeutic immunology 1994;1(4):217-28.
1994: Peter Linsley; Robert Peach; P Gladstone; J Bajorath
Extending the B7 (CD80) gene family.
Protein science : a publication of the Protein Society 1994;3(8):1341-3.
1994: David R Milich; Peter Linsley; J L Hughes; J E Jones
Soluble CTLA-4 can suppress autoantibody production and elicit long term unresponsiveness in a novel transgenic model.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):429-35.
1994: William Stohl; J E Elliott; Peter Linsley
Human T cell-dependent B cell differentiation induced by staphylococcal superantigens.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):117-27.
1994: Thomas C Pearson; DZ Alexander; K J Winn; Peter Linsley; R P Lowry; Christian P Larsen
Transplantation tolerance induced by CTLA4-Ig.
Transplantation 1994;57(12):1701-6.
1994: K Nishikawa; Peter Linsley; A B Collins; Ivan Stamenkovic; Robert T McCluskey; G Andres
Effect of CTLA-4 chimeric protein on rat autoimmune anti-glomerular basement membrane glomerulonephritis.
European journal of immunology 1994;24(6):1249-54.
1994: Christian P Larsen; S C Ritchie; R Hendrix; Peter Linsley; K S Hathcock; Richard J Hodes; R P Lowry; Thomas C Pearson
Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5208-19.
1994: S Guerder; D E Picarella; Peter Linsley; Richard A Flavell
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5138-42.
1994: T Zhou; C Weaver; Peter Linsley; J D Mountz
T cells of staphylococcal enterotoxin B-tolerized autoimmune MRL-lpr/lpr mice require co-stimulation through the B7-CD28/CTLA-4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co-stimulatory signal.
European journal of immunology 1994;24(5):1019-25.
1994: Nitin Damle; K Klussman; G Leytze; S Myrdal; Alejandro Aruffo; Jeffrey A Ledbetter; Peter Linsley
Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2686-97.
1994: M P Cooke; A W Heath; Kevan M Shokat; Y Zeng; F D Finkelman; Peter Linsley; M Howard; Christopher C Goodnow
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.
The Journal of experimental medicine 1994;179(2):425-38.
1994: S F Radka; J C Kallestad; Peter Linsley; M Shoyab
The binding pattern of a neutralizing monoclonal antibody to mutant oncostatin M molecules is correlated with functional activity.
Cytokine 1994;6(1):55-60.
1994: MS Hayden; Peter Linsley; M A Gayle; J Bajorath; W A Brady; N A Norris; H P Fell; Jeffrey A Ledbetter; L K Gilliland
Single-chain mono- and bispecific antibody derivatives with novel biological properties and antitumour activity from a COS cell transient expression system.
Therapeutic immunology 1994;1(1):3-15.
1993: Anne I Sperling; Peter Linsley; Terrence Anthony Barrett; Jeffrey A Bluestone
CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6043-50.
1993: Omar Haffar; M D Smithgall; J Bradshaw; B Brady; Nitin Damle; Peter Linsley
Costimulation of T-cell activation and virus production by B7 antigen on activated CD4+ T cells from human immunodeficiency virus type 1-infected donors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11094-8.
1993: L Chen; Peter Linsley; Karl Erik Hellström
Costimulation of T cells for tumor immunity.
Immunology today 1993;14(10):483-6.
1993: A J Nelson; S Hosier; W Brady; Peter Linsley; Andrew G Farr
Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2453-61.
1993: Nitin Damle; K Klussman; G Leytze; Alejandro Aruffo; Peter Linsley; Jeffrey A Ledbetter
Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2368-79.
1993: M T Dietsch; V F Smith; W L Cosand; Nitin Damle; Jeffrey A Ledbetter; Peter Linsley; Alejandro Aruffo
Bispecific receptor globulins, novel tools for the study of cellular interactions. Preparation and characterization of an E-selectin/P-selectin bispecific receptor globulin.
Journal of immunological methods 1993;162(1):123-32.
1993: L A Jones; D J Izon; JD Nieland; Peter Linsley; Ada M Kruisbeek
CD28-B7 interactions are not required for intrathymic clonal deletion.
International immunology 1993;5(5):503-12.
1993: Nitin Damle; K Klussman; G Leytze; H D Ochs; Alejandro Aruffo; Peter Linsley; Jeffrey A Ledbetter
Costimulation via vascular cell adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7.
Cellular immunology 1993;148(1):144-56.
1993: Peter Linsley; J Bradshaw; M Urnes; LS Grosmaire; Jeffrey A Ledbetter
CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3161-9.
1993: Nitin Damle; K Klussman; G Leytze; Peter Linsley
Proliferation of human T lymphocytes induced with superantigens is not dependent on costimulation by the CD28 counter-receptor B7.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):726-35.
1993: Peter Linsley; J A Ledbetter
The role of the CD28 receptor during T cell responses to antigen.
Annual review of immunology 1993;11():191-212.
1993: P Tan; Claudio Anasetti; John A Hansen; J Melrose; M Brunvand; J Bradshaw; Jeffrey A Ledbetter; Peter Linsley
Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.
The Journal of experimental medicine 1993;177(1):165-73.
1992: L Chen; S Ashe; W A Brady; Ingegerd Hellström; Karl Erik Hellström; Jeffrey A Ledbetter; P McGowan; Peter Linsley
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4.
Cell 1992;71(7):1093-102.
1992: Peter Linsley; J L Greene; P Tan; J Bradshaw; Jeffrey A Ledbetter; Claudio Anasetti; Nitin Damle
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.
The Journal of experimental medicine 1992;176(6):1595-604.
1992: R Tan; Soo-Jeet Teh; Jeffrey A Ledbetter; Peter Linsley; Hung-Sia Teh
B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3217-24.
1992: Laurence A Turka; Peter Linsley; H Lin; W Brady; Jeffrey M Leiden; R Q Wei; M L Gibson; X G Zheng; S Myrdal; David F Gordon
T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):11102-5.
1992: Yang Liu; B Jones; W Brady; Charles A Janeway; Peter Linsley; P S Linley
Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen.
European journal of immunology 1992;22(11):2855-9.
1992: Nitin Damle; K Klussman; Peter Linsley; Alejandro Aruffo; Jeffrey A Ledbetter
Differential regulatory effects of intercellular adhesion molecule-1 on costimulation by the CD28 counter-receptor B7.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2541-8.
1992: Christian P Larsen; S C Ritchie; Thomas C Pearson; Peter Linsley; R P Lowry
Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.
The Journal of experimental medicine 1992;176(4):1215-20.
1992: G L Schieven; J C Kallestad; T J Brown; Jeffrey A Ledbetter; Peter Linsley
Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(5):1676-82.
1992: Peter Linsley; PM Wallace; J Johnson; M G Gibson; J L Greene; Jeffrey A Ledbetter; C Singh; Mark Tepper
Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule.
Science (New York, N.Y.) 1992;257(5071):792-5.
1992: D J Lenschow; Y Zeng; J Richard Thistlethwaite; A Montag; W Brady; M G Gibson; Peter Linsley; Jeffrey A Bluestone
Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg.
Science (New York, N.Y.) 1992;257(5071):789-92.
1992: Yang Liu; Peter Linsley
Costimulation of T-cell growth.
Current opinion in immunology 1992;4(3):265-70.
1992: Nitin Damle; K Klussman; Peter Linsley; Alejandro Aruffo
Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):1985-92.
1992: Steven A Miles; Otoniel Martínez-Maza; Ali R Rezai; L Magpantay; Tadamitsu Kishimoto; S Nakamura; S F Radka; Peter Linsley
Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells.
Science (New York, N.Y.) 1992;255(5050):1432-4.
1992: Yang Liu; B Jones; A Aruffo; K M Sullivan; Peter Linsley; Charles A Janeway
Heat-stable antigen is a costimulatory molecule for CD4 T cell growth.
The Journal of experimental medicine 1992;175(2):437-45.
1992: A G Bruce; Peter Linsley; Timothy M Rose
Oncostatin M.
Progress in growth factor research 1992;4(2):157-70.
1992: Jeffrey A Ledbetter; Peter Linsley
CD28 receptor crosslinking induces tyrosine phosphorylation of PLC gamma 1.
Advances in experimental medicine and biology 1992;323():23-7.