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María Cascales

Research Profile

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Mirandeli Bautista; María Cascales; David Andres; Tomas Fregoso-Aguilar; José Gutiérrez-Salinas; E Madrigal-Santillán; Jorge Alberto Mendoza-Pérez; José A Morales-González; María Isabel Sánchez-Reus; Carmen Valadez-Vega; Jaime Esquivel-Soto
Role of Kupffer cells in thioacetamide-induced cell cycle dysfunction.
Mirandeli Bautista; David Andres; María Cascales; José A Morales-González; María Isabel Sánchez-Reus
Effect of gadolinium chloride on liver regeneration following thioacetamide-induced necrosis in rats.
María Francisca Molina-Jiménez; María Isabel Sánchez-Reus; María Cascales; David Andrés; Juana Benedí
Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.

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All Publications

2011: Mirandeli Bautista; María Cascales; David Andres; Tomas Fregoso-Aguilar; José Gutiérrez-Salinas; E Madrigal-Santillán; Jorge Alberto Mendoza-Pérez; José A Morales-González; María Isabel Sánchez-Reus; Carmen Valadez-Vega; Jaime Esquivel-Soto
Role of Kupffer cells in thioacetamide-induced cell cycle dysfunction.
Molecules (Basel, Switzerland) 2011;16(10):8319-31.
2010: Mirandeli Bautista; David Andres; María Cascales; José A Morales-González; María Isabel Sánchez-Reus
Effect of gadolinium chloride on liver regeneration following thioacetamide-induced necrosis in rats.
International journal of molecular sciences 2010;11(11):4426-40.
2005: María Francisca Molina-Jiménez; María Isabel Sánchez-Reus; María Cascales; David Andrés; Juana Benedí
Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.
Toxicology and applied pharmacology 2005;209(3):214-25.
2005: David Andrés; Mirandeli Bautista; María Cascales
Attenuation of cyclosporine A toxicity by sublethal heat shock. Role of catalase.
Biochemical pharmacology 2005;69(3):493-501.
2005: Inmaculada Bando; María Isabel Sánchez Reus; David Andrés; María Cascales
Endogenous antioxidant defence system in rat liver following mercury chloride oral intoxication.
Journal of biochemical and molecular toxicology 2005;19(3):154-61.
2004: María Francisca Molina-Jiménez; María Isabel Sánchez-Reus; David Andres; María Cascales; Juana Benedi
Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells.
Brain research 2004;1009(1-2):9-16.
2003: David Andrés; Isabel Sánchez-Reus; Mirandeli Bautista; María Cascales
Depletion of Kupffer cell function by gadolinium chloride attenuates thioacetamide-induced hepatotoxicity. Expression of metallothionein and HSP70.
Biochemical pharmacology 2003;66(6):917-26.
2003: Isabel Sánchez Reus; Inmaculada Bando; David Andrés; María Cascales
Relationship between expression of HSP70 and metallothionein and oxidative stress during mercury chloride induced acute liver injury in rats.
Journal of biochemical and molecular toxicology 2003;17(3):161-8.
2002: Carmen Díez-Fernández; David Andrés; María Cascales
Attenuating effects of heat shock against TGF-beta1-induced apoptosis in cultured rat hepatocytes.
Free radical biology & medicine 2002;33(6):835-46.
2002: David Andrés; María Cascales
Novel mechanism of Vitamin E protection against cyclosporine A cytotoxicity in cultured rat hepatocytes.
Biochemical pharmacology 2002;64(2):267-76.
2002: David Andrés; Carmen Díez-Fernández; Antonio Castrillo; María Cascales
Relationship between the activation of heat shock factor and the suppression of nuclear factor-kappaB activity in rat hepatocyte cultures treated with cyclosporine A.
Biochemical pharmacology 2002;64(2):247-56.
2002: Nuria Sanz; Carmen Díez-Fernández; David Andrés; María Cascales
Hepatotoxicity and aging: endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide.
Biochimica et biophysica acta 2002;1587(1):12-20.
2001: A Zaragoza; Carmen Díez-Fernández; Alberto M Alvarez; David Andrés; María Cascales
Mitochondrial involvement in cocaine-treated rat hepatocytes: effect of N-acetylcysteine and deferoxamine.
British journal of pharmacology 2001;132(5):1063-70.
2001: David Andrés; Carmen Díez-Fernández; A Zaragoza; A Alvarez; María Cascales
Induction of cell proliferation by cyclosporine A in primary cultures of rat hepatocytes.
Biochemical pharmacology 2001;61(4):427-35.
2000: David Andrés; Alberto M Alvarez; Carmen Díez-Fernández; A Zaragoza; María Cascales
HSP70 induction by cyclosporine A in cultured rat hepatocytes: effect of vitamin E succinate.
Journal of hepatology 2000;33(4):570-9.
2000: David Andrés; Nuria Sanz; A Zaragoza; Alberto M Alvarez; María Cascales
Changes in antioxidant defence systems induced by cyclosporine A in cultures of hepatocytes from 2- and 12-month-old rats.
Biochemical pharmacology 2000;59(9):1091-100.
2000: A Zaragoza; Carmen Díez-Fernández; Alberto M Alvarez; David Andrés; María Cascales
Effect of N-acetylcysteine and deferoxamine on endogenous antioxidant defense system gene expression in a rat hepatocyte model of cocaine cytotoxicity.
Biochimica et biophysica acta 2000;1496(2-3):183-95.
2000: A Zaragoza; David Andrés; D Sarrión; María Cascales
Potentiation of thioacetamide hepatotoxicity by phenobarbital pretreatment in rats. Inducibility of FAD monooxygenase system and age effect.
Chemico-biological interactions 2000;124(2):87-101.
1999: Carmen Díez-Fernández; A Zaragoza; Alberto M Alvarez; María Cascales
Cocaine cytotoxicity in hepatocyte cultures from phenobarbital-induced rats: involvement of reactive oxygen species and expression of antioxidant defense systems.
Biochemical pharmacology 1999;58(5):797-805.
1999: Nuria Sanz; Carmen Díez-Fernández; Alberto M Alvarez; L Fernández-Simón; María Cascales
Age-related changes on parameters of experimentally-induced liver injury and regeneration.
Toxicology and applied pharmacology 1999;154(1):40-9.
1998: Carmen Díez-Fernández; Nuria Sanz; Alberto M Alvarez; A Wolf; María Cascales
The effect of non-genotoxic carcinogens, phenobarbital and clofibrate, on the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis.
Carcinogenesis 1998;19(10):1715-22.
1998: Carmen Díez-Fernández; Nuria Sanz; Alberto M Alvarez; A Zaragoza; María Cascales
Influence of aminoguanidine on parameters of liver injury and regeneration induced in rats by a necrogenic dose of thioacetamide.
British journal of pharmacology 1998;125(1):102-8.
1998: Nuria Sanz; Carmen Díez-Fernández; L Fernández-Simón; A Alvarez; María Cascales
Necrogenic and regenerative responses of liver of newly weaned rats against a sublethal dose of thioacetamide.
Biochimica et biophysica acta 1998;1384(1):66-78.
1998: Nuria Sanz; Carmen Díez-Fernández; María Cascales
Aging delays the post-necrotic restoration of liver function.
BioFactors (Oxford, England) 1998;8(1-2):103-9.
1998: Carmen Díez-Fernández; Nuria Sanz; A Wolf; María Cascales
Effect of phorbol ester (PMA) on antioxidant enzyme expression in TGF-beta 1-induced apoptosis in primary cultures of hepatocytes.
BioFactors (Oxford, England) 1998;8(1-2):65-71.
1997: Nuria Sanz; Carmen Díez-Fernández; A Alvarez; María Cascales
Age-dependent modifications in rat hepatocyte antioxidant defense systems.
Journal of hepatology 1997;27(3):525-34.
1997: Carmen Díez-Fernández; Nuria Sanz; Lisardo Boscá; Sonsoles Hortelano; María Cascales
Involvement of nitric oxide synthesis in hepatic perturbations induced in rats by a necrogenic dose of thioacetamide.
British journal of pharmacology 1997;121(4):820-6.
1997: Nuria Sanz; Carmen Díez-Fernández; A M Valverde; M Lorenzo; M Benito; María Cascales
Malic enzyme and glucose 6-phosphate dehydrogenase gene expression increases in rat liver cirrhogenesis.
British journal of cancer 1997;75(4):487-92.
1996: Carmen Díez-Fernández; Nuria Sanz; María Cascales
Changes in glucose-6-phosphate dehydrogenase and malic enzyme gene expression in acute hepatic injury induced by thioacetamide.
Biochemical pharmacology 1996;51(9):1159-63.
1996: Carmen Díez-Fernández; Nuria Sanz; María Cascales
Intracellular calcium concentration impairment in hepatocytes from thioacetamide-treated rats. Implications for the activity of Ca(2+)-dependent enzymes.
Journal of hepatology 1996;24(4):460-7.
1996: Nuria Sanz; Carmen Díez-Fernández; María Cascales
Variations of hepatic antioxidant systems and DNA ploidy in rats aged 2 to 8 months.
Biochimica et biophysica acta 1996;1315(2):123-30.
1995: Nuria Sanz; Carmen Díez-Fernández; L Fernández-Simón; A Alvarez; María Cascales
Relationship between antioxidant systems, intracellular thiols and DNA ploidy in liver of rats during experimental cirrhogenesis.
Carcinogenesis 1995;16(7):1585-93.
1994: María Cascales; A Alvarez; P Gascó; L Fernández-Simón; Nuria Sanz; Lisardo Boscá
Cocaine-induced liver injury in mice elicits specific changes in DNA ploidy and induces programmed death of hepatocytes.
Hepatology (Baltimore, Md.) 1994;20(4 Pt 1):992-1001.
1993: Carmen Díez-Fernández; Lisardo Boscá; L Fernández-Simón; A Alvarez; María Cascales
Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide.
Hepatology (Baltimore, Md.) 1993;18(4):912-8.
1993: H Aylagas; Jesús Osada; C Cascales; María Cascales; M J Miró-Obradors; E Palacios-Alaiz
Thioacetamide alters the regulation of cytidylyltransferase activity.
Biochemistry and molecular biology international 1993;29(2):307-15.
1992: María Cascales; P Martin-Sanz; L Bosca
Phorbol esters, bombesin and insulin elicit differential responses on the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase system in primary cultures of foetal and adult rat hepatocytes.
European journal of biochemistry / FEBS 1992;207(1):391-7.
1992: María Cascales; P Martin-Sanz; A Alvarez; M Sanchez-Pérez; C Diez Fernández; Lisardo Boscá
Isoenzymes of carbohydrate metabolism in primary cultures of hepatocytes from thioacetamide-induced rat liver necrosis: responses to growth factors.
Hepatology (Baltimore, Md.) 1992;16(1):232-40.
1992: Paloma Martín-Sanz; María Cascales; Lisardo Boscá
Characterization of 6-phosphofructo-2-kinase from foetal-rat liver.
The Biochemical journal 1992;281 ( Pt 2)():457-63.
1991: María Cascales; Paloma Martín-Sanz; D G Craciunescu; I Mayo; A Aguilar; E M Robles-Chillida; C Cascales
Alterations in hepatic peroxidation mechanisms in thioacetamide-induced tumors in rats. Effect of a rhodium(III) complex.
Carcinogenesis 1991;12(2):233-40.
1990: Jesús Osada; H Aylagas; M J Mirõ-Obradors; C Arce; E Palacios-Alaiz; María Cascales
Effect of acute thioacetamide administration on rat brain phospholipid metabolism.
Neurochemical research 1990;15(9):927-31.
1989: C Cascales; Lisardo Boscá; Paloma Martín-Sanz; D N Brindley; María Cascales
Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats.
Toxicology letters 1989;47(1):9-16.
1989: Paloma Martín-Sanz; C Cascales; María Cascales
Lipogenesis and cholesterogenesis de novo in liver and adipose tissue. Alterations of lipid metabolism by the effect of short- and long-term thioacetamide administration to rats.
Carcinogenesis 1989;10(3):477-81.
1989: P Martin-Sanz; María Cascales; Lisardo Boscá
Glucagon-induced changes in fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase in cultured rat foetal hepatocytes.
The Biochemical journal 1989;257(3):795-9.
1988: C Cascales; Lisardo Boscá; A Martin; D N Brindley; María Cascales
Age-related changes in the translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in rat liver.
Biochimica et biophysica acta 1988;963(2):384-8.
1987: Paloma Martín-Sanz; María Cascales; Lisardo Boscá
Fructose 2,6-bisphosphate in isolated foetal hepatocytes.
FEBS letters 1987;225(1-2):37-42.
1987: P Martin-Sanz; C Cascales; A Gómez; D N Brindley; María Cascales
Effect of a rhodium complex on alterations of hepatic function in thioacetamide-induced hyperplastic noduligenesis in rats.
Carcinogenesis 1987;8(11):1685-90.
1986: C Cascales; P Martin-Sanz; Richard Pittner; R Hopewell; D N Brindley; María Cascales
Effects of an antitumoural rhodium complex on thioacetamide-induced liver tumor in rats. Changes in the activities of ornithine decarboxylase, tyrosine aminotransferase and of enzymes involved in fatty acid and glycerolipid synthesis.
Biochemical pharmacology 1986;35(16):2655-61.
1985: C Cascales; María Cascales; A Santos-Ruiz
Effect of chronic ethanol or acetaldehyde on hepatic alcohol and aldehyde dehydrogenases, aminotransferases and glutamate dehydrogenase.
Revista española de fisiología 1985;41(1):19-27.
1984: B Feijóo; C Toledo; H Aylagas; María Cascales
[Urea and arginase activity in rat liver during the administration of thioacetamide].
Revista española de oncología 1984;31(1):15-20.
1983: C Cascales; M Benito; María Cascales; T Caldés; A Santos-Ruiz
The effect of chronic ethanol administration on lipogenesis in liver and adipose tissue in the rat.
The British journal of nutrition 1983;50(3):549-53.
1983: M R Santos-Ruiz; María Cascales; B Feijóo; C Cascales; A Santos-Ruiz
[Glutamate metabolism in the liver of rats with chronic ethanol intoxication. Effect of nucleotide coenzymes].
Annales pharmaceutiques françaises 1983;40(5):405-15.
1982: María Cascales; M R Santos-Ruiz; C Cascales; A Santos-Ruiz
[Glycolytic and oxidation-reduction metabolism in rat liver in chronic ethanol intoxication. Effect of the administration of nucleotide coenzymes].
Annales pharmaceutiques françaises 1982;40(6):499-510.
1982: Jesús Osada; E Palacios; María Cascales; A Santos-Ruiz
[Effect of thioacetamide on the incorporation of tritiated water into rat liver phospholipids].
Revista española de fisiología 1982;38 Suppl():129-33.
1982: B Feijóo; H Aylagas; María Cascales; A Santos-Ruiz
[Effect of pH and activation on the arginase activity of rat liver treated with thioacetamide].
Revista española de fisiología 1982;38 Suppl():123-7.
1982: M A Santos-Ruiz; María Cascales; M Benito; C Cascales; Paloma Martín-Sanz; A Santos-Ruiz
[Profile of the capacity for lipid synthesis in vivo in various rat tissues: effect of age].
Revista española de fisiología 1982;38 Suppl():119-22.
1982: María Cascales; E M Robles-Chillida; B Feijóo; S Cerdán; Paloma Martín-Sanz; A Santos-Ruiz
[Changes caused by thioacetamide in GOT and GPT aminotransferases and glutamate dehydrogenase in rat liver. Ultrastructural study].
Revista española de fisiología 1982;38 Suppl():105-12.
1982: A Santos-Ruiz; C Cascales; Paloma Martín-Sanz; María Cascales
Metabolic repercussion of coenzyme-A (CoA) in experimental ethanol hepatopathy.
Acta vitaminologica et enzymologica 1982;4(1-2):69-80.
1982: E Palacios; Jesús Osada; María Cascales; A Santos Ruiz
[Changes in lipid metabolism which accompany thioacetamide-induced cirrhosis].
Revista española de oncología 1982;29(3):505-10.
1982: M R Santos-Ruiz; C Cascales; María Cascales; A Santos-Ruiz
[Effect of the administration of nucleotide coenzymes on the lipogenic enzyme changes caused by chronic alcohol intoxication].
Revista española de fisiología 1982;38 Suppl():113-8.
1981: S Cerdán; María Cascales; A Santos-Ruiz
Effect of thioacetamide on the pentose phosphate pathway and other NADP-linked enzymes of rat liver cytosol: chronology of the perturbations and metabolic significance.
Molecular pharmacology 1981;19(3):451-5.