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Kuo-Hsiung Lee

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TOP 3
Wen-Qun Li; Ying-Qian Liu; Susan L Morris-Natschke; Keduo Qian; Jin Tian; Chih-Ya Wang; Xu-Li Wang; Liu Yang; Xing-Wen Zhou; Kuo-Hsiung Lee
Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives.
Qi Wang; Kenneth F Bastow; Tzu-Hsuan Chen; Kuo-Hsiung Lee; Susan L Morris-Natschke; Dao-Feng Chen
Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica.
Zhao Dang; Phong Ho; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Lei Zhu; Chin-Ho Chen
New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.

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All Publications

2013: Wen-Qun Li; Ying-Qian Liu; Susan L Morris-Natschke; Keduo Qian; Jin Tian; Chih-Ya Wang; Xu-Li Wang; Liu Yang; Xing-Wen Zhou; Kuo-Hsiung Lee
Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives.
Bioorganic & medicinal chemistry 2013;21(8):2363-9.
2013: Qi Wang; Kenneth F Bastow; Tzu-Hsuan Chen; Kuo-Hsiung Lee; Susan L Morris-Natschke; Dao-Feng Chen
Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica.
Journal of natural products 2013;76(3):305-10.
2013: Zhao Dang; Phong Ho; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Lei Zhu; Chin-Ho Chen
New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.
Journal of medicinal chemistry 2013;56(5):2029-37.
2013: Ying-Qian Liu; Susan L Morris-Natschke; Xiang Nan; Jing Tian; Liu Yang; Xiao-Ming Yang; Zhi-Jun Zhang; Chun-Yan Zhao; Xing-Wen Zhou; Lin-Hai Li; Xiao-Jing Li; Kuo-Hsiung Lee
Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents.
Bioorganic & medicinal chemistry 2013;21(5):1248-56.
2013: Xiao-Feng Wang; Kenneth F Bastow; Ernest Hamel; Kuo-Hsiung Lee; Susan L Morris-Natschke; Emika Ohkoshi; Sheng-Biao Wang; Lan Xie
Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.
Bioorganic & medicinal chemistry 2013;21(3):632-42.
2013: Shih-Ming Huang; Sheng-Chu Kuo; Ming-Hua Chen; Yung-Yi Cheng; Mei-Hua Hsu; Chi-Hung Huang; Li-Jiau Huang; Kuo-Hsiung Lee
Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-ones as potent antitumor agents.
Bioorganic & medicinal chemistry letters 2013;23(3):699-701.
2013: Hung-Cheng Shih; Hung-Chung Chen; Tsong-Long Hwang; Ping-Chung Kuo; E-Jian Lee; Kuo-Hsiung Lee; Tian-Shung Wu
Honokiol Dimers and Magnolol Derivatives with New Carbon Skeletons from the Roots of Magnolia officinalis and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release.
PloS one 2013;8(5):e59502.
2013: Min Chen; Kuo-Hsiung Lee; Zhihua Liao; Susan L Morris-Natschke; Bing Xu; Xiumei Xu; Panpan Yang; Daofeng Chen
Neglschisandrins E-F: two new lignans and related cytotoxic lignans from Schisandra neglecta.
Molecules (Basel, Switzerland) 2013;18(2):2297-306.
2012: Hsin-Yi Hung; Kyoko Goto; Emika Ohkoshi; Masuo Goto; Kuo-Hsiung Lee
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity.
Bioorganic & medicinal chemistry letters 2012;22(24):7726-9.
2012: Yingqian Liu; Keduo Qian; Chih-Ya Wang; Xiaoming Yang; Chin-Ho Chen; Kuo-Hsiung Lee
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives.
Bioorganic & medicinal chemistry letters 2012;22(24):7530-3.
2012: Ying-Qian Liu; Susan L Morris-Natschke; Chih-Ya Wang; Liu Yang; Xiao-Ming Yang; Xing-Wen Zhou; Wei Dai; Wen-Qun Li; Kuo-Hsiung Lee
Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents.
Bioorganic & medicinal chemistry letters 2012;22(24):7659-61.
2012: Xiao-Feng Wang; Pei-Chi Wu; Kenneth F Bastow; Mann-Jen Hour; Rong Huang; Hsin-Yi Hung; William P Janzen; Jian Jin; Kuo-Hsiung Lee; Yi-Nan Liu; Susan L Morris-Natschke; Emika Ohkoshi; Keduo Qian; Bingjie Qin; Xing-Tao Tian; Lan Xie
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.
Bioorganic & medicinal chemistry letters 2012;22(19):6224-8.
2012: Yung-Yi Cheng; Hsi-Cheng Chien; Jing-Gung Chung; Li-Jiau Huang; Kuo-Hsiung Lee; Chih-Chuang Liaw; Chi-Cheng Lu; Shih-Chang Tsai; Minoru Tsuzuki; Jai-Sing Yang; Sheng-Chu Kuo
The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells.
Oncology reports 2012;28(4):1482-90.
2012: De-Yang Shen; Tran Dinh Thang; Hsiu-Hui Chan; Chih-Hua Chao; Guan-Jhong Huang; Tsong-Long Hwang; Chin-Yu Lai; Kuo-Hsiung Lee; Tian-Shung Wu
Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers.
Phytochemistry 2012;82():110-7.
2012: Keduo Qian; Ibrahim D Bori; Chin-Ho Chen; Li Huang; Kuo-Hsiung Lee
Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.
Journal of medicinal chemistry 2012;55(18):8128-36.
2012: Lian-Qi Sun; Lei Zhu; Chin Ho Chen; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Bingjie Qin; Lan Xie
Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.
Journal of medicinal chemistry 2012;55(16):7219-29.
2012: Zhao Dang; Phong Ho; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Lei Zhu; Chin-Ho Chen
Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.
Bioorganic & medicinal chemistry letters 2012;22(16):5190-4.
2012: Xiaoming Yang; Kenneth F Bastow; Chi-Yuan Chen; Chin-Yu Lai; Emika Ohkoshi; Shiow-Lin Pan; Qian Shi; Che-Ming Teng; Chih-Ya Wang; Tian-Shung Wu; Pan-Chyr Yang; Shuenn-chen YANG; Kuo-Hsiung Lee
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Journal of medicinal chemistry 2012;55(15):6751-61.
2012: Li-Ting Wang; Tzu-Hsuan Chen; Yizhou Dong; Kuo-Hsiung Lee; Shiow-Lin Pan; Che-Ming Teng
DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells.
Chembiochem : a European journal of chemical biology 2012;13(11):1663-72.
2012: Deyong Ye; Hao Zhu; Yung-Chi Cheng; Elizabeth A Gullen; Zao Li Jiang; Seung-Whan Kim; Chung-Hang Leung; Susan L Morris-Natschke; Shin-Young Park; Qian Shi; Kuo-Hsiung Lee
Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents.
Bioorganic & medicinal chemistry 2012;20(14):4489-94.
2012: Qian Shi; Koji Wada; Masuo Goto; Rong Huang; Li Lin; Susan L Morris-Natschke; Emika Ohkoshi; Kuo-Hsiung Lee
Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens.
Bioorganic & medicinal chemistry 2012;20(13):4020-31.
2012: Jie Li; Emika Ohkoshi; Yan Bo Tang; Hui Ming Hua; Kuo-Hsiung Lee; Shipeng Zhang; Zhi yan Xiao
Synthesis and evaluation of novel podophyllotoxin analogs.
Bioorganic & medicinal chemistry letters 2012;22(13):4293-5.
2012: Chiao-Ting Yen; Kenneth F Bastow; Tsong-Long Hwang; Susan L Morris-Natschke; Kyoko Goto; Yang-Chang Wu; Kuo-Hsiung Lee
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents.
Bioorganic & medicinal chemistry letters 2012;22(12):4018-22.
2012: Hsin-Yi Hung; Kenneth F Bastow; Masuo Goto; Kyoko Goto; Emika Ohkoshi; Kuo-Hsiung Lee
Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.
Journal of medicinal chemistry 2012;55(11):5413-24.
2012: Tian-Shung Wu; Chung-Ren Sun; Kuo-Hsiung Lee
Cytotoxic and anti-HIV phenanthroindolizidine alkaloids from Cryptocarya chinensis.
Natural product communications 2012;7(6):725-7.
2012: Hsin-Yi Hung; Susan L Morris-Natschke; Keduo Qian; Chau-Shin Hsu; Kuo-Hsiung Lee
Recent discovery of plant-derived anti-diabetic natural products.
Natural product reports 2012;29(5):580-606.
2012: Ting Zhou; Kenneth F Bastow; Emika Ohkoshi; Qian Shi; Kuo-Hsiung Lee
Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy.
Bioorganic & medicinal chemistry letters 2012;22(9):3219-22.
2012: Kai Xu; Chin-Ho Chen; Li Huang; Emika Ohkoshi; Yan Bo Tang; Zhiyan Xiao; Kuo-Hsiung Lee
Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(8):2772-4.
2012: Lian-Qi Sun; Chin-Ho Chen; Li Huang; Kuo-Hsiung Lee; Keduo Qian; Bingjie Qin; Lan Xie
Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(7):2376-9.
2012: Yizhou Dong; Yoon Kim; Chin-Yu Lai; Eva Y-H P Lee; Susan L Morris-Natschke; Kyoko Goto; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility.
Journal of natural products 2012;75(3):370-7.
2012: Ying Chen; Ming Cheng; Chin-Yu Lai; Hong-Rui Liu; Hong-Shan Liu; Susan L Morris-Natschke; Keduo Qian; Pei-Chi Wu; Peng Xia; Yi Xia; Zheng-Yu Yang; Kuo-Hsiung Lee
Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents.
European journal of medicinal chemistry 2012;49():74-85.
2012: Mei-Hua Hsu; Li-Jiau Huang; Chun-Jen Chen; Yen-Jung Chen; Kuo-Hsiung Lee; Chiao-Min Lin; Yu-Fu Lin; Chin-Yu Liu; Sheng-Chu Kuo
2-(3-Methoxyphenyl)-5-methyl-1,8-naphthyridin-4(1H)-one (HKL-1) induces G2/M arrest and mitotic catastrophe in human leukemia HL-60 cells.
Toxicology and applied pharmacology 2012;259(2):219-26.
2012: Ying Wang; Hui-Chyn Wong; Xiaoming Yang; Elizabeth A Gullen; Wing Lam; Kuo-Hsiung Lee; Qian Shi; Yung-Chi Cheng
Cryptopleurine analogs with modification of e ring exhibit different mechanism to rac-cryptopleurine and tylophorine.
PloS one 2012;7(12):e51138.
2012: Chih-Ya Wang; Ya-Ling Chang; Kuo-Hsiung Lee; Chieh-Yu Peng; Che-Ming Teng; An-Chi Tsai; Shiow-Lin Pan
Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.
PloS one 2012;7(2):e31195.
2012: Hui-Chi Huang; Kuo-Hsiung Lee; Chia-Ching Liaw; Li-Jie Zhang; Chao-Lin Chang; Ih-Sheng Chen; Wen-Chi Chen; Chun-Tang Chiou; Ping-Chun Hsiao; Yao-Haur Kuo
Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai.
Molecules (Basel, Switzerland) 2012;17(2):1837-51.
2012: M Vijaya Bhaskar Reddy; Kenneth F Bastow; Kuo-Hsiung Lee; Emika Ohkoshi; Keduo Qian; Yuh-Chiang Shen; Tian-Shung Wu
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.
European journal of medicinal chemistry 2012;47(1):97-103.
2012: Ting Zhou; Susan L Morris-Natschke; Qian Shi; Chin-Ho Chen; Phong Ho; Li Huang; Kuo-Hsiung Lee
Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents.
European journal of medicinal chemistry 2012;47(1):86-96.
2011: M Vijaya Bhaskar Reddy; Kuo-Hsiung Lee; Keduo Qian; Wei-Jern Tsai; Tian-Shung Wu
Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation.
Bioorganic & medicinal chemistry 2011;19(24):7711-9.
2011: Joana Soares; Xihong Wang; Brian R Keppler; Kuo-Hsiung Lee; Michael B Jarstfer
ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.
Bioorganic & medicinal chemistry letters 2011;21(24):7474-8.
2011: Chien-Ting Chen; Yung-Yi Cheng; Li-Chen Chou; Mei-Hua Hsu; Li-Jiau Huang; Kuo-Hsiung Lee; Chin-Yu Liu; Tian-Shung Wu; Xiaoming Yang; Sheng-Chu Kuo
Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs.
European journal of medicinal chemistry 2011;46(12):6046-56.
2011: Shin-ichiro Kurimoto; Kuo-Hsiung Lee; Yoshiki Kashiwada; Yoshihisa Takaishi
Triterpenes and a triterpene glucoside from Dysoxylum cumingianum.
Phytochemistry 2011;72(17):2205-11.
2011: Jang-Chang Lee; Kuo-Hsiung Lee; Tzong-Der Way; Li-Chen Chou; Jing-Gung Chung; Chi-Hung Huang; Li-Jiau Huang; Mien-Chie Hung; Sheng-Chu Kuo
CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.
European journal of pharmacology 2011;670(1):96-104.
2011: Hong-Shan Liu; Susan L Morris-Natschke; Keduo Qian; Peng Xia; Yi Xia; Shi-Qing Xu; Zheng-Yu Yang; Chin-Ho Chen; Ying Chen; Ming Cheng; Kuo-Hsiung Lee
Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2011;21(19):5831-4.
2011: Ying Chen; Ming Cheng; Chin-Ho Chen; Fa-Qiang Liu; Susan L Morris-Natschke; Keduo Qian; Peng Xia; Yi Xia; Zheng-Yu Yang; Donglei Yu; Kuo-Hsiung Lee
Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues.
European journal of medicinal chemistry 2011;46(10):4924-36.
2011: Keduo Qian; Chin-Ho Chen; Li Huang; Hsin-Yi Hung; Sang-Yong Kim; Kuo-Hsiung Lee
New betulinic acid derivatives as potent proteasome inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(19):5944-7.
2011: Shou-Fang Wu; Fang-Rong Chang; Shu-Li Chen; Tsong-Long Hwang; Kuo-Hsiung Lee; Emika Ohkoshi; Chin-Chung Wu; Yang-Chang Wu
Bioactive components from the heartwood of Pterocarpus santalinus.
Bioorganic & medicinal chemistry letters 2011;21(18):5630-2.
2011: Qiang Wang; Shuyang Wang; Chin-Ho Chen; Xiaohe Guo; Weidong Hu; Kuo-Hsiung Lee; Zhenliang Pan; Keduo Qian; Le Tao; Junbiao Chang
Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.
European journal of medicinal chemistry 2011;46(9):4178-83.
2011: Xiaoming Yang; Sung-Liang Yu; Kenneth F Bastow; Chi-Yuan Chen; Chin-Yu Lai; Jau-Chen Lin; Susan L Morris-Natschke; Shiow-Lin Pan; Qian Shi; Che-Ming Teng; Pei-Chi Wu; Tian-Shung Wu; Pan-Chyr Yang; Shuenn-chen YANG; Kuo-Hsiung Lee
Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents.
Journal of medicinal chemistry 2011;54(14):5097-107.
2011: Ting-Chun Kuo; Po-Cheng Chiang; Chia-Chun Yu; Kyoko Goto; Kenneth F Bastow; Kuo-Hsiung Lee; Jih-Hwa Guh
A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways.
Biochemical pharmacology 2011;81(9):1136-44.
2011: Shih-Ming Huang; Jai-Sing Yang; Shih-Chang Tsai; Ming-Hua Chen; Mei-Hua Hsu; Hui-Yi Lin; Li-Chen Chou; Jo-Hua Chinag; Kuo-Hsiung Lee; Li-Jiau Huang; Sheng-Chu Kuo
The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.
International journal of oncology 2011;38(5):1357-64.
2011: Hsiu-Hui Chan; Tsong-Long Hwang; Mopur Vijaya Bhaskar Reddy; Ding-Tzai Li; Keduo Qian; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.
Journal of natural products 2011;74(4):796-802.
2011: Yizhou Dong; Kyoko Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity.
Bioorganic & medicinal chemistry letters 2011;21(8):2341-4.
2011: Zhao Dang; Andrew Lin; Phong Ho; Dominique Soroka; Kuo-Hsiung Lee; Li Huang; Chin-Ho Chen
Synthesis and proteasome inhibition of lithocholic acid derivatives.
Bioorganic & medicinal chemistry letters 2011;21(7):1926-8.
2011: M Vijaya Bhaskar Reddy; Yuh-Chiang Shen; Jai-Sing Yang; Tsong-Long Hwang; Kenneth F Bastow; Keduo Qian; Kuo-Hsiung Lee; Tian-Shung Wu
New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.
Bioorganic & medicinal chemistry 2011;19(6):1895-906.
2011: Kyoko Goto; Pei-Chi Wu; Chin-Yu Lai; Ernest Hamel; Hao Zhu; Liying Zhang; Takashi Kozaka; Emika Ohkoshi; Masuo Goto; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.
Journal of medicinal chemistry 2011;54(5):1244-55.
2011: Mei-Lin Yang; Ping-Chung Kuo; Tsann-Long Hwang; Wen-Fei Chiou; Keduo Qian; Chin-Yu Lai; Kuo-Hsiung Lee; Tian-Shung Wu
Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives.
Bioorganic & medicinal chemistry 2011;19(5):1674-82.
2011: Kyoko Goto; Pei-Chi Wu; Kenneth F Bastow; Shuenn-chen YANG; Sung-Liang Yu; Hsuan-Yu Chen; Jau-Chen Lin; Masuo Goto; Susan L Morris-Natschke; Pan-Chyr Yang; Kuo-Hsiung Lee
Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action.
Bioorganic & medicinal chemistry 2011;19(5):1816-22.
2011: Yizhou Dong; Susan L Morris-Natschke; Kuo-Hsiung Lee
Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.
Natural product reports 2011;28(3):529-42.
2011: Lalit Oberoi; Toshiyuki Akiyama; Kuo-Hsiung Lee; Shi J Liu
The aqueous extract, not organic extracts, of Terminalia arjuna bark exerts cardiotonic effect on adult ventricular myocytes.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011;18(4):259-65.
2011: Bai-bo Xie; Ming-Ying Shang; Xuan Wang; Shao-Qing Cai; Kuo-Hsiung Lee
[A new aristolochic acid derivative from Asarum himalaicum].
Yao xue xue bao = Acta pharmaceutica Sinica 2011;46(2):188-92.
2011: Li Huang; Kuo-Hsiung Lee; Jie Yu; Lei Zhu; Phong Ho; Chin-Ho Chen
Picomolar dichotomous activity of gnidimacrin against HIV-1.
PloS one 2011;6(10):e26677.
2011: Shin-ichiro Kurimoto; Kuo-Hsiung Lee; Susan L Morris-Natschke; Yoshiki Kashiwada; Yoshihisa Takaishi
Dyscusins A-C, three new steroids from the leaves of Dysoxylum cumingianum.
Chemical & pharmaceutical bulletin 2011;59(10):1303-6.
2011: Bai-Bo Xie; Ming-Ying Shang; Kuo-Hsiung Lee; Xuan Wang; Katsuko Komatsu; Shao-Qing Cai
5-methoxyaristololactam I, the first natural 5-substituted aristololactam from Asarum ichangense.
Natural product communications 2011;6(1):11-4.
2011: Yizhou Dong; Kyoko Goto; Chin-Yu Lai; Yoon Kim; Susan L Morris-Natschke; Eva Y-H P Lee; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents.
Bioorganic & medicinal chemistry letters 2011;21(1):52-7.
2011: Pu Zhang; Li Xu; Keduo Qian; Jun Liu; Luyong Zhang; Kuo-Hsiung Lee; Hongbin Sun
Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.
Bioorganic & medicinal chemistry letters 2011;21(1):338-41.
2011: Li-Shian Shi; Chih-Hua Chao; De-Yang Shen; Hsiu-Hui Chan; Chou-Hsiung Chen; Yu-Ren Liao; Shwu-Jen Wu; Yann-Lii Leu; Yuh-Chiang Shen; Yao-Haur Kuo; E-Jian Lee; Keduo Qian; Tian-Shung Wu; Kuo-Hsiung Lee
Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.
Bioorganic & medicinal chemistry 2011;19(1):677-83.
2011: Yizhou Dong; Kyoko Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.
Bioorganic & medicinal chemistry letters 2011;21(1):546-9.
2010: Ting Zhou; Qian Shi; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3'R,4'R-disubstituted-2',2'-dimethyldihydropyrano[2,3-f]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistance.
Journal of medicinal chemistry 2010;53(24):8700-8.
2010: Shwu-Jen Wu; Yann-Lii Leu; Chou-Hsiung Chen; Chih-Hua Chao; De-Yang Shen; Hsiu-Hui Chan; E-Jian Lee; Tian-Shung Wu; Yea-Hwey Wang; Yuh-Chiang Shen; Keduo Qian; Kenneth F Bastow; Kuo-Hsiung Lee
Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.
Journal of natural products 2010;73(11):1756-62.
2010: Li-Chen Chou; Meng-Tung Tsai; Mei-Hua Hsu; Sheng-Hung Wang; Tzong-Der Way; Chi-Hung Huang; Hui-Yi Lin; Keduo Qian; Yizhou Dong; Kuo-Hsiung Lee; Li-Jiau Huang; Sheng-Chu Kuo
Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.
Journal of medicinal chemistry 2010;53(22):8047-58.
2010: Shi-Qing Xu; Xin Yan; Ying Chen; Peng Xia; Keduo Qian; Donglei Yu; Yi Xia; Zheng-Yu Yang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs.
Bioorganic & medicinal chemistry 2010;18(20):7203-11.
2010: Chao-Lin Chang; Li-Jie Zhang; Ru Yin Chen; Li-Ming Yang Kuo; Jhih-Ping Huang; Hui-Chi Huang; Kuo-Hsiung Lee; Yang-Chang Wu; Yao-Haur Kuo
Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.
Journal of natural products 2010;73(9):1482-8.
2010: Yoshihide Usami; Kyoko Goto; Jing-Yu Lang; Yoon Kim; Chin-Yu Lai; Masuo Goto; Nobuko Sakurai; Masahiko Taniguchi; Toshiyuki Akiyama; Susan L Morris-Natschke; Kenneth F Bastow; Gordon Cragg; David J Newman; Mihoyo Fujitake; Koichi Takeya; Mien-Chie Hung; Eva Y-H P Lee; Kuo-Hsiung Lee
Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.
Journal of natural products 2010;73(9):1553-8.
2010: Kyoko Goto; Po-Cheng Chang; Chin-Yu Lai; Hsin-Yi Hung; Tzu-Hsuan Chen; Pei-Chi Wu; Hao Zhu; Alexander Sedykh; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues.
Journal of medicinal chemistry 2010;53(18):6699-705.
2010: Ting Zhou; Qian Shi; Chin-Ho Chen; Hao Zhu; Li Huang; Phong Ho; Kuo-Hsiung Lee
Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.
Bioorganic & medicinal chemistry 2010;18(18):6678-89.
2010: Juan Xiong; Yoshiki Kashiwada; Chin-Ho Chen; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yoshihisa Takaishi
Conjugates of betulin derivatives with AZT as potent anti-HIV agents.
Bioorganic & medicinal chemistry 2010;18(17):6451-69.
2010: Li-Shian Shi; Yu-Ren Liao; Ming-Jai Su; An-Sheng Lee; Ping-Chung Kuo; Amooru G Damu; Sheng-Chu Kuo; Han-Dong Sun; Kuo-Hsiung Lee; Tian-Shung Wu
Cardiac glycosides from Antiaris toxicaria with potent cardiotonic activity.
Journal of natural products 2010;73(7):1214-22.
2010: Qiang Wang; Yanfeng Li; Chuanjun Song; Keduo Qian; Chin-Ho Chen; Kuo-Hsiung Lee; Junbiao Chang
Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs.
Bioorganic & medicinal chemistry letters 2010;20(14):4053-6.
2010: Yizhou Dong; Kyoko Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
Bioorganic & medicinal chemistry letters 2010;20(14):4085-7.
2010: Takashi Kozaka; Kyoko Goto; Qian Shi; Chin-Yu Lai; Ernest Hamel; Kenneth F Bastow; Arnold Brossi; Kuo-Hsiung Lee
Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents.
Bioorganic & medicinal chemistry letters 2010;20(14):4091-4.
2010: Bingjie Qin; Xingkai Jiang; Hong Lu; Xingtao Tian; Florent Barbault; Li Huang; Keduo Qian; Chin-Ho Chen; Rong Huang; Shibo Jiang; Kuo-Hsiung Lee; Lan Xie
Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2010;53(13):4906-16.
2010: Jian Tang; Keduo Qian; Bei Na Zhang; Ying Chen; Peng Xia; Donglei Yu; Yi Xia; Zheng-Yu Yang; Chin-Ho Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents.
Bioorganic & medicinal chemistry 2010;18(12):4363-73.
2010: Sergio Rosselli; Antonella Maggio; Rosa Angela Raccuglia; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee; Maurizio Bruno
Acid rearrangment of epoxy-germacranolides and absolute configuration of 1beta,10alpha-epoxy-salonitenolide.
Natural product communications 2010;5(5):675-80.
2010: Keduo Qian; Reen-Yun Kuo; Chin-Ho Chen; Li Huang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.
Journal of medicinal chemistry 2010;53(8):3133-41.
2010: Xiaoming Yang; Qian Shi; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 274. A new synthetic strategy for E-ring SAR study of antofine and cryptopleurine analogues.
Organic letters 2010;12(7):1416-9.
2010: Kuo-Hsiung Lee
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
Journal of natural products 2010;73(3):500-16.
2010: Yizhou Dong; Qian Shi; Huei-Chen Pai; Chieh-Yu Peng; Shiow-Lin Pan; Che-Ming Teng; Kyoko Goto; Donglei Yu; Yi-Nan Liu; Pei-Chi Wu; Kenneth F Bastow; Susan L Morris-Natschke; Arnold Brossi; Jing-Yu Lang; Jennifer L Hsu; Mien-Chie Hung; Eva Y-H P Lee; Kuo-Hsiung Lee
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
Journal of medicinal chemistry 2010;53(5):2299-308.
2010: Song-Lin Li; Jing-Zheng Song; Chun-Feng Qiao; Yan Zhou; Keduo Qian; Kuo-Hsiung Lee; Hong Xi XU
A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis.
Journal of pharmaceutical and biomedical analysis 2010;51(4):812-23.
2010: Jin Tatsuzaki; Kyoko Goto; Harukuni Tokuda; Kuo-Hsiung Lee
Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents.
Journal of Asian natural products research 2010;12(3):227-32.
2010: Jiawang Liu; Ming Zhao; Keduo Qian; Xiaoyi Zhang; Kuo-Hsiung Lee; Jianhui Wu; Yi-Nan Liu; Shiqi Peng
Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis.
Bioorganic & medicinal chemistry 2010;18(5):1910-7.
2010: Fang-Rong Chang; Yi-Chung Hsieh; Yung-Fu Chang; Kuo-Hsiung Lee; Yang-Chang Wu; Li-Kwan Chang
Inhibition of the Epstein-Barr virus lytic cycle by moronic acid.
Antiviral research 2010;85(3):490-5.
2010: Yu-Jen Kuo; Yu-Ching Yang; Li-Jie Zhang; Ming-Der Wu; Li-Ming Yang Kuo; Yuh-Chi Kuo; Syh-Yuan Hwang; Cheng-Jen Chou; Kuo-Hsiung Lee; Hsiu-O Ho; Yao-Haur Kuo
Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum.
Journal of natural products 2010;73(2):109-14.
2010: Qi Wang; Tzu-Hsuan Chen; Kenneth F Bastow; Kuo-Hsiung Lee; Dao-Feng Chen
Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from Ligularia altaica.
Journal of natural products 2010;73(2):139-42.
2010: Li-Chen Chou; Chien-Ting Chen; Jang-Chang Lee; Tzong-Der Way; Chi-Hung Huang; Shih-Ming Huang; Che-Ming Teng; Takao Yamori; Tian-Shung Wu; Chung-Ming Sun; Du-Shieng Chien; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee; Li-Jiau Huang; Sheng-Chu Kuo
Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.
Journal of medicinal chemistry 2010;53(4):1616-26.
2010: An-Chi Tsai; Shiow-Lin Pan; Hui-Lung Sun; Chih-Ya Wang; Chieh-Yu Peng; Shih-Wei Wang; Ya-Ling Chang; Sheng-Chu Kuo; Kuo-Hsiung Lee; Che-Ming Teng
CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation.
The Journal of biological chemistry 2010;285(8):5497-506.
2010: Chiao-Ting Yen; Kyoko Goto; Tsong-Long Hwang; Pei-Chi Wu; Susan L Morris-Natschke; Wan-Chun Lai; Kenneth F Bastow; Fang-Rong Chang; Yang-Chang Wu; Kuo-Hsiung Lee
Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents.
Bioorganic & medicinal chemistry letters 2010;20(3):1037-9.
2010: Yizhou Dong; Qian Shi; Kyoko Goto; Pei-Chi Wu; Susan L Morris-Natschke; Arnold Brossi; Kenneth F Bastow; Jing-Yu Lang; Mien-Chie Hung; Kuo-Hsiung Lee
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
Bioorganic & medicinal chemistry 2010;18(2):803-8.
2010: Elizabeth R Sharlow; Todd A Lyda; Heidi C Dodson; Gabriela Mustata; Meredith T Morris; Stephanie S Leimgruber; Kuo-Hsiung Lee; Yoshiki Kashiwada; David Close; John Lazo; James C Morris
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.
PLoS neglected tropical diseases 2010;4(4):e659.
2009: Zhao Dang; Weihong Lai; Keduo Qian; Phong Ho; Kuo-Hsiung Lee; Chin-Ho Chen; Li Huang
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.
Journal of medicinal chemistry 2009;52(23):7887-91.
2009: Sergio Rosselli; Antonella Maggio; Nicoletta Faraone; Vivienne Spadaro; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee; Maurizio Bruno
The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol.
Natural product communications 2009;4(12):1701-6.
2009: Chun-Jen Chen; Yen-Fang Wen; Pi-Tsan Huang; Mei-Hua Hsu; Kuo-Hsiung Lee; Mei-Hwai Chen; Wuu-Chian Shin; Li-Jiau Huang; Sheng-Chu Kuo
2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells.
Leukemia research 2009;33(12):1664-9.
2009: Yizhou Dong; Qian Shi; Kyoko Goto; Pei-Chi Wu; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
Bioorganic & medicinal chemistry letters 2009;19(22):6289-92.
2009: Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.
Natural product reports 2009;26(10):1321-44.
2009: Qian Shi; C C-Y Shih; Kuo-Hsiung Lee
Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity.
Anti-cancer agents in medicinal chemistry 2009;9(8):904-12.
2009: Jianhui Wu; Ming Zhao; Keduo Qian; Kuo-Hsiung Lee; Susan L Morris-Natschke; Shiqi Peng
Novel N-(3-carboxyl-9-benzyl-beta-carboline-1-yl)ethylamino acids: synthesis, anti-tumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation.
European journal of medicinal chemistry 2009;44(10):4153-61.
2009: Xingtao Tian; Bingjie Qin; Hong Lu; Weihong Lai; Shibo Jiang; Kuo-Hsiung Lee; Chin Ho Chen; Lan Xie
Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(18):5482-5.
2009: Xiaoming Yang; Qian Shi; Yi-Nan Liu; Guiyu Zhao; Kenneth F Bastow; Jau-Chen Lin; Shuenn-chen YANG; Pan-Chyr Yang; Kuo-Hsiung Lee
Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents.
Journal of medicinal chemistry 2009;52(16):5262-8.
2009: Chung-Ren Su; Sheau-Farn Yeh; Chih Miem Liu; Amooru G Damu; Tsung-Hsiao Kuo; Po-Cheng Chiang; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Anti-HBV and cytotoxic activities of pyranocoumarin derivatives.
Bioorganic & medicinal chemistry 2009;17(16):6137-43.
2009: Fei Huang; Ming Zhao; Xiaoyi Zhang; Chao Wang; Keduo Qian; Reen-Yen Kuo; Susan L Morris-Natschke; Kuo-Hsiung Lee; Shiqi Peng
Synthesis, DNA intercalation and 3D QSAR analysis of cis-2,4,5-trisubstituted-1,3-dithiolanes as a novel class of antitumor agents.
Bioorganic & medicinal chemistry 2009;17(16):6085-95.
2009: Yu-Hsun Chang; Mei-Hua Hsu; Sheng-Hung Wang; Li-Jiau Huang; Keduo Qian; Susan L Morris-Natschke; Ernest Hamel; Sheng-Chu Kuo; Kuo-Hsiung Lee
Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.
Journal of medicinal chemistry 2009;52(15):4883-91.
2009: Kyoko Goto; Koji Yamada; Masahiko Taniguchi; Harukuni Tokuda; Kuo-Hsiung Lee
Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.
Bioorganic & medicinal chemistry letters 2009;19(13):3378-81.
2009: Yizhou Dong; Qian Shi; Yi-Nan Liu; Xiang Wang; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.
Journal of medicinal chemistry 2009;52(11):3586-90.
2009: Keduo Qian; Donglei Yu; Chin-Ho Chen; Li Huang; Susan L Morris-Natschke; Theodore J Nitz; Karl Salzwedel; Mary Reddick; Graham P Allaway; Kuo-Hsiung Lee
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.
Journal of medicinal chemistry 2009;52(10):3248-58.
2009: Jau-Chen Lin; Shuenn-chen YANG; Tse-Ming Hong; Sung-Liang Yu; Qian Shi; Linyi Wei; Hsuan-Yu Chen; Pan-Chyr Yang; Kuo-Hsiung Lee
Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways.
Journal of medicinal chemistry 2009;52(7):1903-11.
2009: Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
HIV entry inhibitors and their potential in HIV therapy.
Medicinal research reviews 2009;29(2):369-93.
2009: Chia-Lin Lee; Fang-Rong Chang; Ming-Hon Yen; Donglei Yu; Yi-Nan Liu; Kenneth F Bastow; Susan L Morris-Natschke; Yang-Chang Wu; Kuo-Hsiung Lee
Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis.
Journal of natural products 2009;72(2):210-3.
2009: Midori Takasaki; Takao Konoshima; Mutsuo Kozuka; Harukuni Tokuda; Junko Takayasu; Hoyoku Nishino; Masazumi Miyakoshi; Kenji Mizutani; Kuo-Hsiung Lee
Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds.
Bioorganic & medicinal chemistry 2009;17(2):600-5.
2008: Lan Xie; Huan-Fang Guo; Hong Lu; Xiao-Mei Zhuang; An-Ming Zhang; Gang Wu; Jin-Xiu Ruan; Ting Zhou; Donglei Yu; Keduo Qian; Kuo-Hsiung Lee; Shibo Jiang
Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK).
Journal of medicinal chemistry 2008;51(24):7689-96.
2008: Gang Wu; Huan-Fang Guo; Kun Gao; Yi-Nan Liu; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee; Lan Xie
Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.
Bioorganic & medicinal chemistry letters 2008;18(19):5272-6.
2008: Chia-Lin Lee; Kyoko Goto; Donglei Yu; Yi-Nan Liu; Kenneth F Bastow; Susan L Morris-Natschke; Fang-Rong Chang; Yang-Chang Wu; Kuo-Hsiung Lee
Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis.
Bioorganic & medicinal chemistry letters 2008;18(15):4275-7.
2008: M Vijaya Bhaskar Reddy; Chung-Ren Su; Wen-Fei Chiou; Yi-Nan Liu; Rosemary Yin-Hwa Chen; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(15):7358-70.
2008: Li Huang; Donglei Yu; Phong Ho; Keduo Qian; Kuo-Hsiung Lee; Chin-Ho Chen
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.
Bioorganic & medicinal chemistry 2008;16(14):6696-701.
2008: Hideji Itokawa; Susan L Morris-Natschke; Toshiyuki Akiyama; Kuo-Hsiung Lee
Plant-derived natural product research aimed at new drug discovery.
Journal of natural medicines 2008;62(3):263-80.
2008: Kyoko Goto; Kenneth F Bastow; Tzu-Hsuan Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity.
Journal of medicinal chemistry 2008;51(11):3297-303.
2008: Yu Chen; Guohui Cui; Ming Zhao; Chao Wang; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee; Shiqi Peng
Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu.
Bioorganic & medicinal chemistry 2008;16(11):5914-25.
2008: Chung-Ren Su; Amooru G Damu; Po-Cheng Chiang; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee; Tian-Shung Wu
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
Bioorganic & medicinal chemistry 2008;16(11):6233-41.
2008: Chieh-Yu Peng; Shiow-Lin Pan; Kuo-Hsiung Lee; Kenneth F Bastow; Che-Ming Teng
Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo.
Cancer letters 2008;263(1):114-21.
2008: An-Shen Lin; Keduo Qian; Yoshihide Usami; Li Lin; Hideji Itokawa; Charleson Hsu; Susan L Morris-Natschke; Kuo-Hsiung Lee
5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix.
Journal of natural medicines 2008;62(2):164-7.
2008: Yoshihide Usami; Yi-Nan Liu; An-Shen Lin; Makio Shibano; Toshiyuki Akiyama; Hideji Itokawa; Susan L Morris-Natschke; Kenneth F Bastow; Ryoji Kasai; Kuo-Hsiung Lee
Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.
Journal of natural products 2008;71(3):478-81.
2008: Shih-Wei Wang; Shiow-Lin Pan; Yu-Chun Huang; Jih-Hwa Guh; Po-Cheng Chiang; Duen-Yi Huang; Sheng-Chu Kuo; Kuo-Hsiung Lee; Che-Ming Teng
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
Molecular cancer therapeutics 2008;7(2):350-60.
2008: Wenli Gao; Annie Pei-Chun Chen; Chung-Hang Leung; Elizabeth Gullen; Alois Fürstner; Qian Shi; Linyi Wei; Kuo-Hsiung Lee; Yung-Chi Cheng
Structural analogs of tylophora alkaloids may not be functional analogs.
Bioorganic & medicinal chemistry letters 2008;18(2):704-9.
2008: Hideji Itokawa; Qian Shi; Toshiyuki Akiyama; Susan L Morris-Natschke; Kuo-Hsiung Lee
Recent advances in the investigation of curcuminoids.
Chinese medicine 2008;3():11.
2008: Chia-Lin Lee; Fang-Rong Chang; Pei-Wen Hsieh; Michael-Y Chiang; Chin-Chung Wu; Zih-You Huang; Yu-Hsuan Lan; Mei Chen; Kuo-Hsiung Lee; Hsin-Fu Yen; Wen-Chun Hung; Yang-Chang Wu
Cytotoxic ent-abietane diterpenes from Gelonium aequoreum.
Phytochemistry 2008;69(1):276-87.
2007: Ping-Chung Kuo; Ya-Ching Shen; Mei-Lin Yang; Su-Hui Wang; Tran Dinh Thang; Nguyen Xuan Dung; Po-Cheng Chiang; Kuo-Hsiung Lee; E-Jian Lee; Tian-Shung Wu
Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents.
Journal of natural products 2007;70(12):1906-9.
2007: Keduo Qian; Kyoko Goto; Donglei Yu; Susan L Morris-Natschke; Theodore J Nitz; Nicole Kilgore; Graham P Allaway; Kuo-Hsiung Lee
Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.
Bioorganic & medicinal chemistry letters 2007;17(23):6553-7.
2007: Shih-Wei Wang; Shiow-Lin Pan; Chieh-Yu Peng; Der-Yi Huang; An-Chi Tsai; Ya-Ling Chang; Jih-Hwa Guh; Sheng-Chu Kuo; Kuo-Hsiung Lee; Che-Ming Teng
CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.
Cancer letters 2007;257(1):87-96.
2007: Madoka Suzuki; Donglei Yu; Susan L Morris-Natschke; Philip C Smith; Kuo-Hsiung Lee
Anti-AIDS agents 66: syntheses and anti-HIV activity of phenolic and aza 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives.
Bioorganic & medicinal chemistry 2007;15(21):6852-8.
2007: Kyoko Goto; Koji Yamada; Seikou Nakamura; Tzu-Hsuan Chen; Po-Cheng Chiang; Kenneth F Bastow; Shao-Chun Wang; Bill Spohn; Mien-Chie Hung; Fang-Yu Lee; Fang-Chen Lee; Kuo-Hsiung Lee
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(18):5204-9.
2007: Jin Tatsuzaki; Masahiko Taniguchi; Kenneth F Bastow; Kyoko Goto; Susan L Morris-Natschke; Hideji Itokawa; Kimiye Baba; Kuo-Hsiung Lee
Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.
Bioorganic & medicinal chemistry 2007;15(18):6193-9.
2007: Makio Shibano; An-Shen Lin; Hideji Itokawa; Kuo-Hsiung Lee
Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF).
Journal of natural products 2007;70(9):1424-8.
2007: An-Shen Lin; Kyoko Goto; Fang-Rong Chang; Donglei Yu; Susan L Morris-Natschke; Chin-Chung Wu; Shu-Li Chen; Yang-Chang Wu; Kuo-Hsiung Lee
First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.
Journal of medicinal chemistry 2007;50(16):3921-7.
2007: Qi Wang; Qing Mu; Makio Shibano; Susan L Morris-Natschke; Kuo-Hsiung Lee; Dao-Feng Chen
Eremophilane sesquiterpenes from Ligularia macrophylla.
Journal of natural products 2007;70(8):1259-62.
2007: Li-Bo Zhou; Tzu-Hsuan Chen; Kenneth F Bastow; Makio Shibano; Kuo-Hsiung Lee; Dao-Feng Chen
Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.
Journal of natural products 2007;70(8):1263-7.
2007: Yang Wang; Shao-Xu Huang; Peng Xia; Yi Xia; Zheng-Yu Yang; Nicole Kilgore; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK.
Bioorganic & medicinal chemistry letters 2007;17(15):4316-9.
2007: Linyi Wei; Qian Shi; Kenneth F Bastow; Arnold Brossi; Susan L Morris-Natschke; Kyoko Goto; Tian-Shung Wu; Shiow-Lin Pan; Che-Ming Teng; Kuo-Hsiung Lee
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.
Journal of medicinal chemistry 2007;50(15):3674-80.
2007: Kyoko Goto; Tzu-Hsuan Chen; Chieh-Yu Peng; Kenneth F Bastow; Jiu-Hong Wu; Kuo-Hsiung Lee
Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs.
Journal of medicinal chemistry 2007;50(14):3354-8.
2007: Amooru G Damu; Ping-Chung Kuo; Chung-Ren Su; Tsung-Hsiao Kuo; Tzu-Hsuan Chen; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
Journal of natural products 2007;70(7):1146-52.
2007: Kyoko Goto; Seikou Nakamura; Kenneth F Bastow; Alexander Nyarko; Chieh-Yu Peng; Fang-Yu Lee; Fang-Chen Lee; Kuo-Hsiung Lee
Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(10):2894-8.
2007: Yen-Fang Wen; Kuo-Hsiung Lee; Pi-Tsan Huang; Mei-Hwai Chen; Wuu-Chian Shin; Li-Jiau Huang; Mei-Hua Hsu; Chun-Jen Chen; Sheng-Chu Kuo
Cell differentiation enhancement by hydrophilic derivatives of 4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-diones in HL-60 leukemia cells.
Bioorganic & medicinal chemistry letters 2007;17(10):2908-12.
2007: Sergio Rosselli; Maurizio Bruno; Antonella Maggio; Gabriella Bellone; Tzu-Hsuan Chen; Kenneth F Bastow; Kuo-Hsiung Lee
Cytotoxic activity of some natural and synthetic ent-kauranes.
Journal of natural products 2007;70(3):347-52.
2007: Zhiming Wen; David E Martin; Peter Bullock; Kuo-Hsiung Lee; Philip C Smith
Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):440-8.
2007: Shuxing Zhang; Linyi Wei; Kenneth F Bastow; Weifan Zheng; Arnold Brossi; Kuo-Hsiung Lee; Alexander Tropsha
Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents.
Journal of computer-aided molecular design 2007;21(1-3):97-112.
2007: Xihong Wang; Susan L Morris-Natschke; Kuo-Hsiung Lee
New developments in the chemistry and biology of the bioactive constituents of Tanshen.
Medicinal research reviews 2007;27(1):133-48.
2007: Donglei Yu; Susan L Morris-Natschke; Kuo-Hsiung Lee
New developments in natural products-based anti-AIDS research.
Medicinal research reviews 2007;27(1):108-32.
2006: Min Chen; Nicole Kilgore; Kuo-Hsiung Lee; Dao-Feng Chen
Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.
Journal of natural products 2006;69(12):1697-701.
2006: Mamoru Okasaka; Yoshihisa Takaishi; Yoshiki Kashiwada; Olimjon K Kodzhimatov; Ozodbek Ashurmetov; Ai J Lin; L Mark Consentino; Kuo-Hsiung Lee
Terpenoids from Juniperus polycarpus var. seravschanica.
Phytochemistry 2006;67(24):2635-40.
2006: Pei-Lin Wu; Yu-Lin Hsu; Tian-Shung Wu; Kenneth F Bastow; Kuo-Hsiung Lee
Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis.
Organic letters 2006;8(23):5207-10.
2006: Jin Tatsuzaki; Kenneth F Bastow; Kyoko Goto; Seiko Nakamura; Hideji Itokawa; Kuo-Hsiung Lee
Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.
Journal of natural products 2006;69(10):1445-9.
2006: Linyi Wei; Arnold Brossi; Ross Kendall; Kenneth F Bastow; Susan L Morris-Natschke; Qian Shi; Kuo-Hsiung Lee
Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents.
Bioorganic & medicinal chemistry 2006;14(19):6560-9.
2006: Xihong Wang; Kyoko Goto; Kenneth F Bastow; Ming-Jaw Don; Yun-Lian Lin; Tian-Shung Wu; Kuo-Hsiung Lee
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
Journal of medicinal chemistry 2006;49(18):5631-4.
2006: Donglei Yu; Yojiro Sakurai; Chin-Ho Chen; Fang-Rong Chang; Li Huang; Yoshiki Kashiwada; Kuo-Hsiung Lee
Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.
Journal of medicinal chemistry 2006;49(18):5462-9.
2006: Masafumi Horiuch; Chihiro Murakami; Narihiko Fukamiya; Donglei Yu; Tzu-Hsuan Chen; Kenneth F Bastow; De-Cheng Zhang; Yoshihisa Takaishi; Yasuhiro Imakura; Kuo-Hsiung Lee
Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids.
Journal of natural products 2006;69(9):1271-4.
2006: Zhiming Wen; Stephan T Stern; David E Martin; Kuo-Hsiung Lee; Philip C Smith
Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1436-42.
2006: Ping-Chung Kuo; Tsung-Hsiao Kuo; Amooru G Damu; Chung-Ren Su; E-Jian Lee; Tian-Shung Wu; Rexen Shu; Chou-Ming Chen; Kenneth F Bastow; Tzu-Hsuan Chen; Kuo-Hsiung Lee
Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.
Organic letters 2006;8(14):2953-6.
2006: Li Lin; Qian Shi; Alexander K Nyarko; Kenneth F Bastow; Chin-Chung Wu; Ching-Yuan Su; Charles C-Y Shih; Kuo-Hsiung Lee
Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.
Journal of medicinal chemistry 2006;49(13):3963-72.
2006: Hui-Chi Huang; Wei-Jern Tsai; Susan L Morris-Natschke; Harukuni Tokuda; Kuo-Hsiung Lee; Yang-Chang Wu; Yueh-Hsiung Kuo
Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi.
Journal of natural products 2006;69(5):763-7.
2006: Nobuko Sakurai; Kyoko Goto; Junko Ito; Yojiro Sakurai; Yuka Nakanishi; Kenneth F Bastow; Gordon Cragg; Kuo-Hsiung Lee
Cytotoxic Alangium alkaloids from Alangium longiflorum.
Phytochemistry 2006;67(9):894-7.
2006: Li Lin; Qian Shi; Ching-Yuan Su; Charles C-Y Shih; Kuo-Hsiung Lee
Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents.
Bioorganic & medicinal chemistry 2006;14(8):2527-34.
2006: Li Huang; Phong Ho; Kuo-Hsiung Lee; Chin-Ho Chen
Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.
Bioorganic & medicinal chemistry 2006;14(7):2279-89.
2006: Yojiro Sakurai; Nobuko Sakurai; Masahiko Taniguchi; Yuka Nakanishi; Kenneth F Bastow; Xihong Wang; Gordon Cragg; Kuo-Hsiung Lee
Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis.
Journal of natural products 2006;69(3):397-9.
2006: Fang-Rong Chang; I-Hsiao Chen; Sin-Chung Liao; Hamad H Issa; Ken-ichiro Hayashi; Hiroshi Nozaki; Yang-Chang Wu; Kuo-Hsiung Lee
Three new agarofuran sesquiterpenes reissantins F-H from Reissantia buchananii.
Planta medica 2006;72(1):92-6.
2005: Maurizio Bruno; Sergio Rosselli; Antonella Maggio; Rosa Angela Raccuglia; Kenneth F Bastow; Chin-Chung Wu; Kuo-Hsiung Lee
Cytotoxic activity of some natural and synthetic sesquiterpene lactones.
Planta medica 2005;71(12):1176-8.
2005: Lan Xie; Chun-hui Zhao; Ting Zhou; Hai-Feng Chen; Bo-Tao Fan; Xian-Hong Chen; Jian-Zhou Ma; Jing-Yun Li; Zhuo-Yi Bao; Zhaowen Lo; Donglei Yu; Kuo-Hsiung Lee
Molecular modeling, design, synthesis, and biological evaluation of novel 3',4'-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents.
Bioorganic & medicinal chemistry 2005;13(23):6435-49.
2005: Ming-Jen Cheng; Kuo-Hsiung Lee; Ian-Lih Tsai; Ih-Sheng Chen
Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides.
Bioorganic & medicinal chemistry 2005;13(21):5915-20.
2005: Madoka Suzuki; Yutai Li; Philip C Smith; James A Swenberg; David E Martin; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents 65: investigation of the in vitro oxidative metabolism of 3',4'-Di-O-(-)-camphanoyl-(+)-cis-khellactone derivatives as potent anti-hiv agents.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(11):1588-92.
2005: Chih-Chuang Liaw; Fang-Rong Chang; Shu-Li Chen; Chin-Chung Wu; Kuo-Hsiung Lee; Yang-Chang Wu
Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
Bioorganic & medicinal chemistry 2005;13(15):4767-76.
2005: Seikou Nakamura; Mutsuo Kozuka; Kenneth F Bastow; Harukuni Tokuda; Hoyoku Nishino; Madoka Suzuki; Jin Tatsuzaki; Susan L Morris-Natschke; Sheng-Chu Kuo; Kuo-Hsiung Lee
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.
Bioorganic & medicinal chemistry 2005;13(14):4396-401.
2005: Naonobu Tanaka; Mamoru Okasaka; Youko Ishimaru; Yoshihisa Takaishi; Mitsunobu Sato; Masato Okamoto; Tetsuya Oshikawa; Sharif Uddin Ahmed; L Mark Consentino; Kuo-Hsiung Lee
Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium.
Organic letters 2005;7(14):2997-9.
2005: Maurizio Bruno; Sergio Rosselli; Antonella Maggio; Rosa Angela Raccuglia; Kenneth F Bastow; Kuo-Hsiung Lee
Cytotoxic activity of some natural and synthetic guaianolides.
Journal of natural products 2005;68(7):1042-6.
2005: Yueh-Hsiung Kuo; Hui-Chi Huang; Li-Ming Yang Kuo; Ya-Wen Hsu; Kuo-Hsiung Lee; Fang-Rong Chang; Yang-Chang Wu
New dammarane-type saponins from the galls of Sapindus mukorossi.
Journal of agricultural and food chemistry 2005;53(12):4722-7.
2005: Kyoko Goto; Kenneth F Bastow; Jiu-Hong Wu; Harukuni Tokuda; Kuo-Hsiung Lee
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.
Bioorganic & medicinal chemistry letters 2005;15(12):3016-9.
2005: Donglei Yu; Carl T Wild; David E Martin; Susan L Morris-Natschke; Chin-Ho Chen; Graham P Allaway; Kuo-Hsiung Lee
The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV.
Expert opinion on investigational drugs 2005;14(6):681-93.
2005: Hai-Feng Chen; Bo-Tao Fan; Chen-Yang Zhao; Lan Xie; Chun-hui Zhao; Ting Zhou; Kuo-Hsiung Lee; Graham Allaway
Computational studies and drug design for HIV-1 reverse transcriptase inhibitors of 3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs.
Journal of computer-aided molecular design 2005;19(4):243-58.
2005: Zhengrong Zou; Yanghua Yi; Houming Wu; Xinsheng Yao; Lijun Du; Wu Jiuhong; Chih-Chaung Liaw; Kuo-Hsiung Lee
Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.
Journal of natural products 2005;68(4):540-6.
2005: Narihiko Fukamiya; Kuo-Hsiung Lee; Ilias Muhammad; Chihiro Murakami; Masayoshi Okano; Isabelle Harvey; Jerry Pelletier
Structure-activity relationships of quassinoids for eukaryotic protein synthesis.
Cancer letters 2005;220(1):37-48.
2005: Kyoko Goto; Jiu-Hong Wu; Kenneth F Bastow; Chin-Chung Wu; Kuo-Hsiung Lee
Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.
Bioorganic & medicinal chemistry 2005;13(6):2325-30.
2005: Hui-Kang Wang; Nokuko Sakurai; Charles Y Shih; Kuo-Hsiung Lee
LC/TIS-MS fingerprint profiling of Cimicifuga species and analysis of 23-Epi-26-deoxyactein in Cimicifuga racemosa commercial products.
Journal of agricultural and food chemistry 2005;53(5):1379-86.
2005: Li Huang; Xiong Yuan; Donglei Yu; Kuo-Hsiung Lee; Chin Ho Chen
Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives.
Virology 2005;332(2):623-8.
2005: Nobuko Sakurai; Mutsuo Kozuka; Harukuni Tokuda; Teruo Mukainaka; Fumio Enjo; Hoyoku Nishino; Masahiro Nagai; Yojiro Sakurai; Kuo-Hsiung Lee
Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds.
Bioorganic & medicinal chemistry 2005;13(4):1403-8.
2005: Yoshiki Kashiwada; Akihiro Aoshima; Yasumasa Ikeshiro; Yuh-Pan Chen; Hiroshi Furukawa; Masataka Itoigawa; Toshihiro Fujioka; Kunihide Mihashi; L Mark Cosentino; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids.
Bioorganic & medicinal chemistry 2005;13(2):443-8.
2005: Ya-Yun Lai; Li-Jiau Huang; Kuo-Hsiung Lee; Zhiyan Xiao; Kenneth F Bastow; Takao Yamori; Sheng-Chu Kuo
Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.
Bioorganic & medicinal chemistry 2005;13(1):265-75.
2005: Kyoko Goto; Cyril X Chen; Ernest Hamel; Chin-Chung Wu; Kenneth F Bastow; Arnold Brossi; Kuo-Hsiung Lee
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
Bioorganic & medicinal chemistry letters 2005;15(1):235-8.
2005: Pei-Lin Wu; Tian-Shung Wu; Cai-Xia He; Chia-Hao Su; Kuo-Hsiung Lee
Constituents from the stems of Hibiscus taiwanensis.
Chemical & pharmaceutical bulletin 2005;53(1):56-9.
2004: Ying Chen; Qian Zhang; Beina Zhang; Peng Xia; Yi Xia; Zheng-Yu Yang; Nicole Kilgore; Carl Wild; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs.
Bioorganic & medicinal chemistry 2004;12(24):6383-7.
2004: Qian Zhang; Ying Chen; Peng Xia; Yi Xia; Zheng-Yu Yang; Donglei Yu; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents. Part 62: anti-HIV activity of 2'-substituted 4-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs.
Bioorganic & medicinal chemistry letters 2004;14(23):5855-7.
2004: Yoshiki Kashiwada; Michiko Sekiya; Yasumasa Ikeshiro; Toshihiro Fujioka; Nicole Kilgore; Carl T Wild; Graham P Allaway; Kuo-Hsiung Lee
3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents.
Bioorganic & medicinal chemistry letters 2004;14(23):5851-3.
2004: Xihong Wang; Kenneth F Bastow; Chang-Ming Sun; Yun-Lian Lin; Hsi-Jung Yu; Ming-Jaw Don; Tian-Shung Wu; Seikou Nakamura; Kuo-Hsiung Lee
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
Journal of medicinal chemistry 2004;47(23):5816-9.
2004: Yousuke Kawaguchi; Toshimasa Ochi; Yoshihisa Takaishi; Kazuyoshi Kawazoe; Kuo-Hsiung Lee
New sesquiterpenes from Capsicum annuum.
Journal of natural products 2004;67(11):1893-6.
2004: Naonobu Tanaka; Yoshihisa Takaishi; Yasuhiro Shikishima; Yuka Nakanishi; Kenneth F Bastow; Kuo-Hsiung Lee; Gisho Honda; Michiho Ito; Yoshio Takeda; Olimjon K Kodzhimatov; Ozodbek Ashurmetov
Prenylated benzophenones and xanthones from Hypericum scabrum.
Journal of natural products 2004;67(11):1870-5.
2004: Chih-Chuang Liaw; Fang-Rong Chang; Yang-Chang Wu; Hui-Kang Wang; Yuka Nakanishi; Kenneth F Bastow; Kuo-Hsiung Lee
Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana.
Journal of natural products 2004;67(11):1804-8.
2004: Zhiyan Xiao; Kenneth F Bastow; John R Vance; Robert S Sidwell; Hui-Kang Wang; Ming S Chen; Qian Shi; Kuo-Hsiung Lee
Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.
Journal of medicinal chemistry 2004;47(21):5140-8.
2004: Chih-Chuang Liaw; Fang-Rong Chang; Chin-Chung Wu; Shu-Li Chen; Kenneth F Bastow; Ken-ichiro Hayashi; Hiroshi Nozaki; Kuo-Hsiung Lee; Yang-Chang Wu
Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
Planta medica 2004;70(10):948-59.
2004: Chihiro Murakami; Narihiko Fukamiya; Sadaaki Tamura; Masayoshi Okano; Kenneth F Bastow; Harukuni Tokuda; Teruo Mukainaka; Hoyoky Nishino; Kuo-Hsiung Lee
Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids.
Bioorganic & medicinal chemistry 2004;12(18):4963-8.
2004: Xiao-Kang Zhu; Jian Guan; Zhiyan Xiao; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives.
Bioorganic & medicinal chemistry 2004;12(15):4267-73.
2004: Donglei Yu; Chin-Ho Chen; Arnold Brossi; Kuo-Hsiung Lee
Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents.
Journal of medicinal chemistry 2004;47(16):4072-82.
2004: Naonobu Tanaka; Nobuyuki Ooba; Hongquan Duan; Yoshihisa Takaishi; Yuka Nakanishi; Kenneth F Bastow; Kuo-Hsiung Lee
Kaurane and abietane diterpenoids from Tripterygium doianum (Celastraceae).
Phytochemistry 2004;65(14):2071-6.
2004: Pei-Wen Hsieh; Fang-Rong Chang; Kuo-Hsiung Lee; Tsann-Long Hwang; Sue-Ming Chang; Yang-Chang Wu
A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra.
Journal of natural products 2004;67(7):1175-7.
2004: Peng Xia; Zhi-Jian Yin; Ying Chen; Qian Zhang; Beina Zhang; Yi Xia; Zheng-Yu Yang; Nicole Kilgore; Carl Wild; Susan L Morris-Natschke; Kuo-Hsiung Lee
Anti-AIDS agents. Part 58: synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues.
Bioorganic & medicinal chemistry letters 2004;14(12):3341-3.
2004: Chia-Ying Li; Chun-Hua Lin; Chia-Che Wu; Kuo-Hsiung Lee; Tian-Shung Wu
Efficient 1H nuclear magnetic resonance method for improved quality control analyses of Ginkgo constituents.
Journal of agricultural and food chemistry 2004;52(12):3721-5.
2004: Zhiyan Xiao; John R Vance; Kenneth F Bastow; Arnold Brossi; Hui-Kang Wang; Kuo-Hsiung Lee
Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential.
Bioorganic & medicinal chemistry 2004;12(12):3363-9.
2004: Zhiyan Xiao; Kenneth F Bastow; John R Vance; Kuo-Hsiung Lee
Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.
Bioorganic & medicinal chemistry 2004;12(12):3339-44.
2004: Shiqing Han; Zhiyan Xiao; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(11):2979-82.
2004: Kenichiro Hayashi; Fang-Rong Chang; Yuka Nakanishi; Kenneth F Bastow; Gordon Cragg; Andrew T McPhail; Hiroshi Nozaki; Kuo-Hsiung Lee
Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.
Journal of natural products 2004;67(6):990-3.
2004: Yong-Hong Wang; Ai-Jun Hou; Lei Chen; Dao-Feng Chen; Han-Dong Sun; Qin-Shi Zhao; Kenneth F Bastow; Yuka Nakanish; Xi-Hong Wang; Kuo-Hsiung Lee
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
Journal of natural products 2004;67(5):757-61.
2004: Zhiyan Xiao; Shiqing Han; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.
Bioorganic & medicinal chemistry letters 2004;14(6):1581-4.
2004: Nobuko Sakurai; Jiu-Hong Wu; Yutaka Sashida; Yoshihiro Mimaki; Tamotsu Nikaido; Kazuo Koike; Hideji Itokawa; Kuo-Hsiung Lee
Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.
Bioorganic & medicinal chemistry letters 2004;14(5):1329-32.
2004: Ru-Wei Lin; Ian-Lih Tsai; Chang-Yih Duh; Kuo-Hsiung Lee; Ih-Sheng Chen
New lignans and cytotoxic constituents from Wikstroemia lanceolata.
Planta medica 2004;70(3):234-8.
2004: Pei-Lin Wu; Fu-Wen Lin; Tian-Shung Wu; Chang-Sheng Kuoh; Kuo-Hsiung Lee; Shiow-Ju Lee
Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis.
Chemical & pharmaceutical bulletin 2004;52(3):345-9.
2004: Kuo-Hsiung Lee
Current developments in the discovery and design of new drug candidates from plant natural product leads.
Journal of natural products 2004;67(2):273-83.
2004: Ping-Chung Kuo; Amooru G Damu; Kuo-Hsiung Lee; Tian-Shung Wu
Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia.
Bioorganic & medicinal chemistry 2004;12(3):537-44.
2004: Lan Xie; Donglei Yu; Carl Wild; Graham P Allaway; Jim Turpin; Philip C Smith; Kuo-Hsiung Lee
Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives.
Journal of medicinal chemistry 2004;47(3):756-60.
2004: Jing Zhou; Xiong Yuan; David Dismuke; Brett M Forshey; Christopher A Lundquist; Kuo-Hsiung Lee; Christopher Aiken; Chin Ho Chen
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation.
Journal of virology 2004;78(2):922-9.
2003: Pei-Wen Hsieh; Fang-Rong Chang; Andrew T McPhail; Kuo-Hsiung Lee; Yang-Chang Wu
New cembranolide analogues from the formosan soft coral Sinularia flexibilis and their cytotoxicity.
Natural product research 2003;17(6):409-18.
2003: Hironori Ohtsu; Hideji Itokawa; Zhiyan Xiao; Ching-Yuan Su; Charles C-Y Shih; Tzuying Chiang; Eugene Chang; YiFen Lee; Shang Yi Chiu; Chawnshang Chang; Kuo-Hsiung Lee
Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids.
Bioorganic & medicinal chemistry 2003;11(23):5083-90.
2003: Fang-Rong Chang; Kenichiro Hayashi; I-Hsiao Chen; Chih-Chuang Liaw; Kenneth F Bastow; Yuka Nakanishi; Hiroshi Nozaki; Gordon Cragg; Yang-Chang Wu; Kuo-Hsiung Lee
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.
Journal of natural products 2003;66(11):1416-20.
2003: Ping-Chung Kuo; Li-Shian Shi; Amooru G Damu; Chung-Ren Su; Chieh-Hung Huang; Chih-Huang Ke; Jin-Bin Wu; Ai-Jeng Lin; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.
Journal of natural products 2003;66(10):1324-7.
2003: Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F Bastow; Yuka Nakanishi; Priya Nampoothiri; Ernest Hamel; Arnold Brossi; Kuo-Hsiung Lee
Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.
Bioorganic & medicinal chemistry letters 2003;13(17):2891-3.
2003: Zheng-rong Zou; Yang-Hua Yi; Hou-Ming Wu; Jiu-Hong Wu; Chih-Chaung Liaw; Kuo-Hsiung Lee
Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.
Journal of natural products 2003;66(8):1055-60.
2003: Yuka Nakanishi; Fang-Rong Chang; Chih-Chuang Liaw; Yang-Chang Wu; Kenneth F Bastow; Kuo-Hsiung Lee
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
Journal of medicinal chemistry 2003;46(15):3185-8.
2003: Jiu-Hong Wu; Fang-Rong Chang; Kenichiro Hayashi; Hiroaki Shiraki; Chih-Chuang Liaw; Yuka Nakanishi; Kenneth F Bastow; Donglei Yu; Ih-Sheng Chen; Kuo-Hsiung Lee
Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis.
Bioorganic & medicinal chemistry letters 2003;13(13):2223-5.
2003: Jiu-Hong Wu; Xi-Hong Wang; Yang-Hua Yi; Kuo-Hsiung Lee
Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos.
Bioorganic & medicinal chemistry letters 2003;13(10):1813-5.
2003: Donglei Yu; Arnold Brossi; Nicole Kilgore; Carl Wild; Graham P Allaway; Kuo-Hsiung Lee
Anti-HIV agents. Part 55: 3'R,4'R-Di-(O)-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent.
Bioorganic & medicinal chemistry letters 2003;13(9):1575-6.
2003: Donglei Yu; Madoka Suzuki; Lan Xie; Susan L Morris-Natschke; Kuo-Hsiung Lee
Recent progress in the development of coumarin derivatives as potent anti-HIV agents.
Medicinal research reviews 2003;23(3):322-45.
2003: Hironori Ohtsu; Yuka Nakanishi; Kenneth F Bastow; Fang-Yu Lee; Kuo-Hsiung Lee
Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry 2003;11(8):1851-7.
2003: Wen-Li Lo; Chin-Chung Wu; Fang-Rong Chang; Wei-Ya Wang; Ashraf Taha Khalil; Kuo-Hsiung Lee; Yang-Chang Wu
Antiplatelet and anti-HIV constituents from Euchresta formosana.
Natural product research 2003;17(2):91-7.
2003: Nobuko Sakurai; Mutsuo Kozuka; Harukuni Tokuda; Yoshitaka Nobukuni; Junko Takayasu; Hoyoku Nishino; Akiko Kusano; Genjiro Kusano; Masahiro Nagai; Yojiro Sakurai; Kuo-Hsiung Lee
Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Bioorganic & medicinal chemistry 2003;11(6):1137-40.
2003: Qian Zhang; Ying Chen; Yun Qing Zheng; Peng Xia; Yi Xia; Zheng Yu Yang; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee
Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters.
Bioorganic & medicinal chemistry 2003;11(6):1031-4.
2003: Alexander Golbraikh; Min Shen; Zhiyan Xiao; Yun-De Xiao; Kuo-Hsiung Lee; Alexander Tropsha
Rational selection of training and test sets for the development of validated QSAR models.
Journal of computer-aided molecular design 2003;17(2-4):241-53.
2003: Yuh-Chwen Chang; Pei-Wen Hsieh; Fang-Rong Chang; Ru-Rong Wu; Chih-Chuang Liaw; Kuo-Hsiung Lee; Yang-Chang Wu
Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.
Planta medica 2003;69(2):148-52.
2003: I-Chen Sun; Yoshiki Kashiwada; Susan L Morris-Natschke; Kuo-Hsiung Lee
Plant-derived terpenoids and analogues as anti-HIV agents.
Current topics in medicinal chemistry 2003;3(2):155-69.
2003: Kenichiro Hayashi; Yuka Nakanishi; Kenneth F Bastow; Gordon Cragg; Hiroshi Nozaki; Kuo-Hsiung Lee
Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras.
Journal of natural products 2003;66(1):125-7.
2002: Hironori Ohtsu; Zhiyan Xiao; Junko Ishida; Masahiro Nagai; Hui-Kang Wang; Hideji Itokawa; Ching-Yuan Su; Charles Shih; Tzuying Chiang; Eugene Chang; YiFen Lee; Meng-Yin Tsai; Chawnshang Chang; Kuo-Hsiung Lee
Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.
Journal of medicinal chemistry 2002;45(23):5037-42.
2002: Maurizio Bruno; Sergio Rosselli; Ivana Pibiri; Nicole Kilgore; Kuo-Hsiung Lee
Anti-HIV agents derived from the ent-kaurane diterpenoid linearol.
Journal of natural products 2002;65(11):1594-7.
2002: Junko Ishida; Hironori Ohtsu; Yoko Tachibana; Yuka Nakanishi; Kenneth F Bastow; Masahiro Nagai; Hui-Kang Wang; Hideji Itokawa; Kuo-Hsiung Lee
Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(11):3481-7.
2002: Shiqing Han; Ernest Hamel; Kenneth F Bastow; Andrew T McPhail; Arnold Brossi; Kuo-Hsiung Lee
Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
Bioorganic & medicinal chemistry letters 2002;12(20):2851-3.
2002: Youichi Shinozaki; Narihiko Fukamiya; Chieko Uchiyama; Masayoshi Okano; Kiyoshi Tagahara; Kenneth F Bastow; Kuo-Hsiung Lee
Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis.
Bioorganic & medicinal chemistry letters 2002;12(19):2785-8.
2002: Junko Ishida; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; Seiji Nagumo; Kuo-Hsiung Lee; Masahiro Nagai
Chemopreventive potential of cyclic diarylheptanoids.
Bioorganic & medicinal chemistry 2002;10(10):3361-5.
2002: I-Chen Sun; Chin-Ho Chen; Yoshiki Kashiwada; Jiu-Hong Wu; Hui-Kang Wang; Kuo-Hsiung Lee
Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.
Journal of medicinal chemistry 2002;45(19):4271-5.
2002: Dao-Feng Chen; Shun-Xiang Zhang; Mutsuo Kozuka; Quan-Zhong Sun; Ju Feng; Qiang Wang; Teruo Mukainaka; Yoshitaka Nobukuni; Harukuni Tokuda; Hoyoku Nishino; Hui-Kang Wang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
Journal of natural products 2002;65(9):1242-5.
2002: Zhiyan Xiao; Yun-De Xiao; Jun Feng; Alexander Golbraikh; Alexander Tropsha; Kuo-Hsiung Lee
Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.
Journal of medicinal chemistry 2002;45(11):2294-309.
2002: Youichi Shinozaki; Narihiko Fukamiya; Masao Fukushima; Masayoshi Okano; Tatsuo Nehira; Kiyoshi Tagahara; Shun-Xiang Zhang; De-Cheng Zhang; Kuo-Hsiung Lee
Dantaxusins C and D, two novel taxoids from Taxus yunnanensis.
Journal of natural products 2002;65(3):371-4.
2002: Prapai Wongsinkongman; Arnold Brossi; Hui-Kang Wang; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(3):583-91.
2002: Kenichiro Hayashi; Yuka Nakanishi; Kenneth F Bastow; Gordon Cragg; Hiroshi Nozaki; Kuo-Hsiung Lee
Antitumor agents. Part 212. Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras.
Bioorganic & medicinal chemistry letters 2002;12(3):345-8.
2001: Y M Zhu; JK Shen; Hui-Kang Wang; L Mark Cosentino; Kuo-Hsiung Lee
Synthesis and anti-HIV activity of oleanolic acid derivatives.
Bioorganic & medicinal chemistry letters 2001;11(24):3115-8.
2001: H I Cheng; W Y Lin; Chang-Yih Duh; Kuo-Hsiung Lee; Ian-Lih Tsai; Ih-Sheng Chen
New cytotoxic butanolides from Litsea acutivena.
Journal of natural products 2001;64(12):1502-5.
2001: Yi Xia; Zheng-Yu Yang; Peng Xia; T Hackl; Ernest Hamel; Anthony B Mauger; Jiu-Hong Wu; Kuo-Hsiung Lee
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.
Journal of medicinal chemistry 2001;44(23):3932-6.
2001: Qian Shi; Hui-Kang Wang; Kenneth F Bastow; Y Tachibana; K Chen; F Y Lee; Kuo-Hsiung Lee
Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry 2001;9(11):2999-3004.
2001: Kinuko Iwasa; Masataka Moriyasu; Y Tachibana; H S Kim; Y Wataya; Wolfgang Wiegrebe; Kenneth F Bastow; L Mark Cosentino; Mutsuo Kozuka; Kuo-Hsiung Lee
Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents.
Bioorganic & medicinal chemistry 2001;9(11):2871-84.
2001: J Ito; Fang-Rong Chang; Hui-Kang Wang; Y K Park; M Ikegaki; Nicole Kilgore; Kuo-Hsiung Lee
Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.
Journal of natural products 2001;64(10):1278-81.
2001: Lan Xie; Graham P Allaway; Carl Wild; Nicole Kilgore; Kuo-Hsiung Lee
Anti-AIDS agents. Part 47: Synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives.
Bioorganic & medicinal chemistry letters 2001;11(17):2291-3.
2001: Youichi Shinozaki; Narihiko Fukamiya; Masao Fukushima; Masayoshi Okano; Tatsuo Nehira; Kiyoshi Tagahara; Shun-Xiang Zhang; De-Cheng Zhang; Kuo-Hsiung Lee
Dantaxusins A and B, two new taxoids from Taxus yunnanensis.
Journal of natural products 2001;64(8):1073-6.
2001: Junko Ishida; Hui-Kang Wang; M Oyama; M L Cosentino; CQ Hu; Kuo-Hsiung Lee
Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.
Journal of natural products 2001;64(7):958-60.
2001: H H Cheng; Hui-Kang Wang; J Ito; Kenneth F Bastow; Y Tachibana; Y Nakanishi; Z Xu; T Y Luo; Kuo-Hsiung Lee
Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum.
Journal of natural products 2001;64(7):915-9.
2001: Yasuhiro Shikishima; Yoshihisa Takaishi; Gisho Honda; Michiho Ito; Y Takfda; Olimjon K Kodzhimatov; Ozodbek Ashurmetov; Kuo-Hsiung Lee
Chemical constituents of Prangos tschiniganica; structure elucidation and absolute configuration of coumarin and furanocoumarin derivatives with anti-HIV activity.
Chemical & pharmaceutical bulletin 2001;49(7):877-80.
2001: Lallan Mishra; R Sinha; Hideji Itokawa; Kenneth F Bastow; Y Tachibana; Y Nakanishi; N Kilgore; Kuo-Hsiung Lee
Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2'-benzimidazolyl)-pyridine/chalcone as co-ligand.
Bioorganic & medicinal chemistry 2001;9(7):1667-71.
2001: D S VanVliet; Y Tachibana; Kenneth F Bastow; Eng-Shang Huang; Kuo-Hsiung Lee
Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents.
Journal of medicinal chemistry 2001;44(9):1422-8.
2001: Yueh-Hsiung Kuo; Shyh-Yuan Li; Ray-Ling Huang; Ming-Der Wu; Hui-Chi Huang; Kuo-Hsiung Lee
Schizanrins [corrected] B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities.
Journal of natural products 2001;64(4):487-90.
2001: Lan Xie; Y Takeuchi; L Mark Cosentino; Andrew T McPhail; Kuo-Hsiung Lee
Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone analogues.
Journal of medicinal chemistry 2001;44(5):664-71.
2001: T C Ko; Mann-Jen Hour; J C Lien; Che-Ming Teng; Kuo-Hsiung Lee; Sheng-Chu Kuo; Li-Jiau Huang
Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.
Bioorganic & medicinal chemistry letters 2001;11(3):279-82.
2001: Yoshiki Kashiwada; J Chiyo; Yasumasa Ikeshiro; T Nagao; Hikaru Okabe; L Mark Cosentino; KR Fowke; Kuo-Hsiung Lee
3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents.
Bioorganic & medicinal chemistry letters 2001;11(2):183-5.
2001: Tian-Shung Wu; Z J Tsang; Pei-Lin Wu; Fu-Wen Lin; Chia-Ying Li; C M Teng; Kuo-Hsiung Lee
New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris.
Bioorganic & medicinal chemistry 2001;9(1):77-83.
2001: SL Holz-Smith; I C Sun; L Jin; Thomas J Matthews; Kuo-Hsiung Lee; Chin Ho Chen
Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564.
Antimicrobial agents and chemotherapy 2001;45(1):60-6.
2000: Kuo-Hsiung Lee
Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine.
Public health nutrition 2000;3(4A):515-22.
2000: Shyh-Yuan Li; Ming-Der Wu; C W Wang; Yueh-Hsiung Kuo; Ray-Ling Huang; Kuo-Hsiung Lee
A novel anti-HBeAg homolignan, taiwanschirin D from Kadsura matsudai.
Chemical & pharmaceutical bulletin 2000;48(12):1992-3.
2000: Z Xu; Fang-Rong Chang; Hui-Kang Wang; Yoshiki Kashiwada; Andrew T McPhail; Kenneth F Bastow; Y Tachibana; M Cosentino; Kuo-Hsiung Lee
Anti-HIV agents 45(1) and antitumor agents 205.(2) two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana.
Journal of natural products 2000;63(12):1712-5.
2000: Yoshiki Kashiwada; Tsuneatsu Nagao; A Hashimoto; Yasumasa Ikeshiro; Hikaru Okabe; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.
Journal of natural products 2000;63(12):1619-22.
2000: Mann-Jen Hour; Li-Jiau Huang; Sheng-Chu Kuo; Y Xia; Kenneth F Bastow; Y Nakanishi; E Hamel; Kuo-Hsiung Lee
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 2000;43(23):4479-87.
2000: J Ishida; Mutsuo Kozuka; H Wang; Takao Konoshima; Harukuni Tokuda; M Okuda; X Yang Mou; Hoyoku Nishino; Nobuko Sakurai; Kuo-Hsiung Lee; Masahiro Nagai
Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2000;159(2):135-40.
2000: Masao Fukushima; Narihiko Fukamiya; Masayoshi Okano; Tatsuo Nehira; Kiyoshi Tagahara; Shun-Xiang Zhang; De-Cheng Zhang; Y Tachibana; Kenneth F Bastow; Kuo-Hsiung Lee
Cytotoxity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line.
Cancer letters 2000;158(2):151-4.
2000: Yoshiki Kashiwada; J Chiyo; Yasumasa Ikeshiro; T Nagao; Hikaru Okabe; L Mark Cosentino; KR Fowke; Susan L Morris-Natschke; Kuo-Hsiung Lee
Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives.
Chemical & pharmaceutical bulletin 2000;48(9):1387-90.
2000: Masataka Itoigawa; Yoshiki Kashiwada; C Ito; H Furukawa; Y Tachibana; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
Journal of natural products 2000;63(7):893-7.
2000: Cherng-Chyi Tzeng; Kuo-Hsiung Lee; Tai-Chi Wang; C H Han; Yeh-Long Chen
Synthesis and cytotoxic evaluation of a series of gamma-substituted gamma-aryloxymethyl-alpha-methylene-gamma-butyrolactones against cancer cells.
Pharmaceutical research 2000;17(6):715-9.
2000: Sadaaki Tamura; Narihiko Fukamiya; XY Mou; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kazuo Koike; Kuo-Hsiung Lee; Masayoshi Okano
Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol.
Chemical & pharmaceutical bulletin 2000;48(6):876-8.
2000: Zheng-Yu Yang; Yi Xia; Peng Xia; Arnold Brossi; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues.
Bioorganic & medicinal chemistry letters 2000;10(10):1003-5.
2000: Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F Bastow; Yuka Nakanishi; Kuo-Hsiung Lee
Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2000;10(8):699-701.
2000: Hongquan Duan; Yoshihisa Takaishi; Y Imakura; Y Jia; D Li; L M Cosentino; Kuo-Hsiung Lee
Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents.
Journal of natural products 2000;63(3):357-61.
2000: P Zhou; Yoshihisa Takaishi; Hongquan Duan; B Chen; Gisho Honda; M Itoh; Yoshio Takeda; Olimjon K Kodzhimatov; Kuo-Hsiung Lee
Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.
Phytochemistry 2000;53(6):689-97.
2000: J Y Chang; X Guo; H X Chen; Z Jiang; Qin Fu; H K Wang; Kenneth F Bastow; Xiao-Kang Zhu; Jian Guan; Kuo-Hsiung Lee; Yung-Chi Cheng
Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4beta-amino-4'-O-demethylepipodophyllotoxin conjugates.
Biochemical pharmacology 2000;59(5):497-508.
2000: S X Zhang; Jun Feng; Sheng-Chu Kuo; Arnold Brossi; Ernest Hamel; Alexander Tropsha; Kuo-Hsiung Lee
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.
Journal of medicinal chemistry 2000;43(2):167-76.
2000: Y Tachibana; Xiao-Kang Zhu; P Krishnan; Kuo-Hsiung Lee; Kenneth F Bastow
Characterization of human lung cancer cells resistant to 4'-O-demethyl-4beta-(2"-nitro-4"-fluoroanilino)-4-desoxypodophyllotoxin , a unique compound in the epipodophyllotoxin antitumor class.
Anti-cancer drugs 2000;11(1):19-28.
1999: Yi Xia; Zheng-Yu Yang; Arnold Brossi; Kuo-Hsiung Lee
Asymmetric solid-phase synthesis of (3'R,4'R)-di-O-cis-acyl 3-carboxyl khellactones.
Organic letters 1999;1(13):2113-5.
1999: Junko Ishida; Hui-Kang Wang; Kenneth F Bastow; CQ Hu; Kuo-Hsiung Lee
Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
Bioorganic & medicinal chemistry letters 1999;9(23):3319-24.
1999: Kuo-Hsiung Lee
Novel antitumor agents from higher plants.
Medicinal research reviews 1999;19(6):569-96.
1999: M Ohyama; T Tanaka; T Ito; M Iinuma; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.
Bioorganic & medicinal chemistry letters 1999;9(20):3057-60.
1999: S X Zhang; Kenneth F Bastow; Y Tachibana; Sheng-Chu Kuo; Ernest Hamel; Anthony B Mauger; V L Narayanan; Kuo-Hsiung Lee
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 1999;42(20):4081-7.
1999: Peng Xia; Z Y Yang; Y Xia; Y Q Zheng; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents.
Bioorganic & medicinal chemistry 1999;7(9):1907-11.
1999: L Xie; Y Takeuchi; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents.
Journal of medicinal chemistry 1999;42(14):2662-72.
1999: Kuo-Hsiung Lee
Anticancer drug design based on plant-derived natural products.
Journal of biomedical science 1999;6(4):236-50.
1999: Xiao-Kang Zhu; Jian Guan; Y Tachibana; Kenneth F Bastow; S J Cho; H H Cheng; Yung-Chi Cheng; M Gurwith; Kuo-Hsiung Lee
Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
Journal of medicinal chemistry 1999;42(13):2441-6.
1999: YH Chao; Sheng-Chu Kuo; K Ku; I P Chiu; C H Wu; Anthony B Mauger; H K Wang; Kuo-Hsiung Lee
Synthesis and cytotoxicity of methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione derivatives.
Bioorganic & medicinal chemistry 1999;7(6):1025-31.
1999: Zheng-Yu Yang; Yi Xia; Peng Xia; Y Tachibana; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds.
Bioorganic & medicinal chemistry letters 1999;9(5):713-6.
1999: Y Xia; Z Y Yang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Recent advances in the discovery and development of quinolones and analogs as antitumor agents.
Current medicinal chemistry 1999;6(3):179-94.
1999: T Hayashi; T Nakano; Mutsuo Kozuka; D R McPhail; Andrew T McPhail; Kuo-Hsiung Lee
Antitumor agents. 190. Absolute stereochemistry of the cytotoxic germacranolides, tomenphantins A and B, from Elephantopus tomentosus.
Journal of natural products 1999;62(2):302-4.
1999: A Banerjee; L T Kasmala; E Hamel; L Sun; Kuo-Hsiung Lee
Interaction of novel thiocolchicine analogs with the tubulin isoforms from bovine brain.
Biochemical and biophysical research communications 1999;254(2):334-7.
1999: Kuo-Hsiung Lee; B R Huang; Cherng-Chyi Tzeng
Synthesis and anticancer evaluation of certain alpha-methylene-gamma-(4-substituted phenyl)-gamma-butyrolactone bearing thymine, uracil, and 5-bromouracil.
Bioorganic & medicinal chemistry letters 1999;9(2):241-4.
1999: K Hirata; Chihiro Ito; Hiroshi Furukawa; Masataka Itoigawa; L Mark Cosentino; Kuo-Hsiung Lee
Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 1999;9(2):119-22.
1999: K Chen; Qian Shi; Z L Li; C D Poon; R J Tang; Kuo-Hsiung Lee
Structures and stereochemistry of pseudolarolides K and L, novel triterpene dilactones from pseudolarix kaempferi.
Journal of Asian natural products research 1999;1(3):207-14.
1999: Masao Fukushima; J Takeda; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Shun-Xiang Zhang; De-Cheng Zhang; Kuo-Hsiung Lee
A new taxoid, 19-acetoxytaxagifine, from Taxus chinensis.
Journal of natural products 1999;62(1):140-2.
1999: Dao-Feng Chen; S X Zhang; Hui-Kang Wang; S Y Zhang; Quan-Zhong Sun; L M Cosentino; Kuo-Hsiung Lee
Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba.
Journal of natural products 1999;62(1):94-7.
1998: Toshihiro Fujioka; M Yamamoto; Yoshiki Kashiwada; Hajime Fujii; Kunihide Mihashi; Yasumasa Ikeshiro; Ih-Sheng Chen; Kuo-Hsiung Lee
Novel cytotoxic diterpenes from the stem of Dysoxylum kuskusense.
Bioorganic & medicinal chemistry letters 1998;8(24):3479-82.
1998: Li-Jiau Huang; F C Chang; Kuo-Hsiung Lee; Jih-Pyang Wang; Che-Ming Teng; Sheng-Chu Kuo
Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds.
Bioorganic & medicinal chemistry 1998;6(12):2261-9.
1998: YH Chao; Sheng-Chu Kuo; C H Wu; C Y Lee; Anthony B Mauger; I-Chen Sun; Susan L Morris-Natschke; Kuo-Hsiung Lee
Synthesis and cytotoxicity of 2-acetyl-4,8-dihydrobenzodithiophene-4, 8-dione derivatives.
Journal of medicinal chemistry 1998;41(23):4658-61.
1998: I-Chen Sun; Hui-Kang Wang; Yoshiki Kashiwada; JK Shen; L Mark Cosentino; Chin-Ho Chen; L M Yang; Kuo-Hsiung Lee
Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.
Journal of medicinal chemistry 1998;41(23):4648-57.
1998: Jian Guan; Xiao-Kang Zhu; Y Tachibana; Kenneth F Bastow; Arnold Brossi; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors.
Bioorganic & medicinal chemistry 1998;6(11):2127-31.
1998: Tai-Chi Wang; Kuo-Hsiung Lee; Yeh-Long Chen; Shorong-Shii Liou; Cherng-Chyi Tzeng
Synthesis and anticancer evaluation of certain gamma-aryloxymethyl-alpha-methylene-gamma-phenyl-gamma-butyrolactones.
Bioorganic & medicinal chemistry letters 1998;8(19):2773-6.
1998: Li-Jiau Huang; Sheng-Chu Kuo; C Y Perng; YH Chao; Tian-Shung Wu; A T McPhail; Anthony B Mauger; H H Cheng; Kuo-Hsiung Lee
Synthesis and cytotoxicity of acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones.
Bioorganic & medicinal chemistry letters 1998;8(19):2763-8.
1998: Li-Jiau Huang; M C Hsieh; Che-Ming Teng; Kuo-Hsiung Lee; Sheng-Chu Kuo
Synthesis and antiplatelet activity of phenyl quinolones.
Bioorganic & medicinal chemistry 1998;6(10):1657-62.
1998: Yoshiki Kashiwada; Hui-Kang Wang; T Nagao; S Kitanaka; I Yasuda; T Fujioka; T Yamagishi; L Mark Cosentino; Mutsuo Kozuka; Hikaru Okabe; Yasumasa Ikeshiro; CQ Hu; E Yeh; Kuo-Hsiung Lee
Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.
Journal of natural products 1998;61(9):1090-5.
1998: Lan Xie; Y Takeuchi; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents. 33. Synthesis and anti-HIV activity of mono-methyl substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) analogues.
Bioorganic & medicinal chemistry letters 1998;8(16):2151-6.
1998: R Tawa; Dayuan Gao; M Takami; Y Imakura; Kuo-Hsiung Lee; Hiromu Sakurai
Binding affinity of Cu(II)-VP-16 (etoposide) complex and its analogues to DNA and hydroxyl radical generation during DNA strand breaks.
Bioorganic & medicinal chemistry 1998;6(7):1003-8.
1998: Zheng-Yu Yang; Yi Xia; Peng Xia; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents. 31. Synthesis and anti-HIV activity of 4-substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) thiolactone analogs.
Bioorganic & medicinal chemistry letters 1998;8(12):1483-6.
1998: Qian Shi; K Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Recent progress in the development of tubulin inhibitors as antimitotic antitumor agents.
Current pharmaceutical design 1998;4(3):219-48.
1998: Jian Guan; Xiao-Kang Zhu; Y Tachibana; Kenneth F Bastow; Arnold Brossi; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Journal of medicinal chemistry 1998;41(11):1956-61.
1998: I-Chen Sun; JK Shen; Hui-Kang Wang; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives.
Bioorganic & medicinal chemistry letters 1998;8(10):1267-72.
1998: F R Chang; P Y Yang; J Y Lin; Kuo-Hsiung Lee; Y C Wu
Bioactive kaurane diterpenoids from Annona glabra.
Journal of natural products 1998;61(4):437-9.
1998: Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F Bastow; Y Tachibana; Sheng-Chu Kuo; Ernest Hamel; T Hackl; Kuo-Hsiung Lee
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Journal of medicinal chemistry 1998;41(7):1155-62.
1998: Hui-Kang Wang; Y Xia; Z Y Yang; S L Natschke; Kuo-Hsiung Lee
Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents.
Advances in experimental medicine and biology 1998;439():191-225.
1997: Qian Shi; P Verdier-Pinard; Arnold Brossi; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis.
Bioorganic & medicinal chemistry 1997;5(12):2277-82.
1997: Fumio Hashimoto; Yoshiki Kashiwada; L Mark Cosentino; C H Chen; P E Garrett; Kuo-Hsiung Lee
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.
Bioorganic & medicinal chemistry 1997;5(12):2133-43.
1997: Jin-Cherng Lien; Li-Jiau Huang; Jih-Pyang Wang; Che-Ming Teng; Kuo-Hsiung Lee; Sheng-Chu Kuo
Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives.
Bioorganic & medicinal chemistry 1997;5(12):2111-20.
1997: Yoshiki Kashiwada; Toshihiro Fujioka; Kunihide Mihashi; Ih-Sheng Chen; H Katayama; Yasumasa Ikeshiro; Kuo-Hsiung Lee
Antitumor agents. 180. Chemical Studies and cytotoxic evaluation of cumingianosides and cumindysoside A, antileukemic triterpene glucosides with a 14,18-cycloapotirucallane skeleton.
Journal of natural products 1997;60(11):1105-14.
1997: K Chen; Sheng-Chu Kuo; M C Hsieh; Anthony B Mauger; C M Lin; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.
Journal of medicinal chemistry 1997;40(19):3049-56.
1997: S Rahman; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee
Anti-tuberculosis activity of quassinoids.
Chemical & pharmaceutical bulletin 1997;45(9):1527-9.
1997: R Tawa; M Takami; Y Imakura; Kuo-Hsiung Lee; Hiromu Sakurai
Breaks in double-strand DNA by Cu(II) complexes of etoposide (VP-16) and its derivatives, as evaluated by S1 nuclease treatment.
Biological & pharmaceutical bulletin 1997;20(9):1002-5.
1997: Jia-Feng Zeng; GL Li; Jing-Kang Shen; Da-Yuan Zhu; Kaixian Chen; Kuo-Hsiung Lee
Manuifolins D, E, and F: new isoflavonoids from Maackia tenuifolia.
Journal of natural products 1997;60(9):918-20.
1997: Daofeng Chen; S X Zhang; L Xie; J X Xie; K Chen; Yoshiki Kashiwada; B N Zhou; P Wang; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues.
Bioorganic & medicinal chemistry 1997;5(8):1715-23.
1997: N Ohno; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee
Synthesis of cytotoxic fluorinated quassinoids.
Bioorganic & medicinal chemistry 1997;5(8):1489-95.
1997: Kenneth F Bastow; H K Wang; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents--CLXXIII. Synthesis and evaluation of camptothecin-4 beta-amino-4'-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents.
Bioorganic & medicinal chemistry 1997;5(8):1481-8.
1997: M G Johnson; H Kiyokawa; S Tani; J Koyama; Susan L Morris-Natschke; Anthony B Mauger; M M Bowers-Daines; B C Lange; Kuo-Hsiung Lee
Antitumor agents--CLXVII. Synthesis and structure-activity correlations of the cytotoxic anthraquinone 1,4-bis-(2,3-epoxypropylamino)-9,10-anthracenedione, and of related compounds.
Bioorganic & medicinal chemistry 1997;5(8):1469-79.
1997: Y H Kuo; C I Chang; S Y Li; C J Chou; C F Chen; Y H Kuo; Kuo-Hsiung Lee
Cytotoxic constituents from the stems of Diospyros maritima.
Planta medica 1997;63(4):363-5.
1997: K Chen; Sheng-Chu Kuo; M C Hsieh; Anthony B Mauger; C M Lin; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 1997;40(14):2266-75.
1997: Hui-Kang Wang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents.
Medicinal research reviews 1997;17(4):367-425.
1997: Tian-Shung Wu; M J Liou; C S Kuoh; C M Teng; T Nagao; Kuo-Hsiung Lee
Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.
Journal of natural products 1997;60(6):606-8.
1997: S Rahman; Narihiko Fukamiya; N Ohno; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano
Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation.
Chemical & pharmaceutical bulletin 1997;45(4):675-7.
1997: Qian Shi; P Verdier-Pinard; Arnold Brossi; Ernest Hamel; Andrew T McPhail; Kuo-Hsiung Lee
Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.
Journal of medicinal chemistry 1997;40(6):961-6.
1997: K Kubota; Narihiko Fukamiya; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano
Quassinoids as inhibitors of Epstein-Barr virus early antigen activation.
Cancer letters 1997;113(1-2):165-8.
1997: Toshihiro Fujioka; A Sakurai; Kunihide Mihashi; Yoshiki Kashiwada; Ih-Sheng Chen; Kuo-Hsiung Lee
Antitumor agents. 169 Dysoxylum cumingianum. V. Cumingianosides P and Q, new cytotoxic triterpene glucosides with an apotirucallane-type skeleton from Dysoxylum cumingianum.
Chemical & pharmaceutical bulletin 1997;45(1):202-6.
1997: Toshihiro Fujioka; A Sakurai; Kunihide Mihashi; Yoshiki Kashiwada; Ih-Sheng Chen; Kuo-Hsiung Lee
Antitumor agents. 168. Dysoxylum cumingianum. IV. The structures of cumingianosides G-O, new triterpene glucosides with a 14,18-cycloapotirucallane-type skeleton from Dysoxylum cumingianum, and their cytotoxicity against human cancer cell lines.
Chemical & pharmaceutical bulletin 1997;45(1):68-74.
1996: K Chen; Y L Zhang; Z L Li; Qian Shi; C D Poon; R J Tang; Andrew T McPhail; Kuo-Hsiung Lee
Structure and stereochemistry of pseudolarolide J, a novel nortriterpene lactone from Pseudolarix kaempferi.
Journal of natural products 1996;59(12):1200-2.
1996: Daofeng Chen; S X Zhang; K Chen; B N Zhou; P Wang; L Mark Cosentino; Kuo-Hsiung Lee
Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.
Journal of natural products 1996;59(11):1066-8.
1996: K Kubota; Narihiko Fukamiya; T Hamada; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee
Two new quassinoids, ailantinols A and B, and related compounds from Ailanthus altissima.
Journal of natural products 1996;59(7):683-6.
1996: J C Lien; Li-Jiau Huang; Jih-Pyang Wang; C M Teng; Kuo-Hsiung Lee; Sheng-Chu Kuo
Synthesis and antiplatelet, antiinflammatory and antiallergic activities of 2,3-disubstituted 1,4-naphthoquinones.
Chemical & pharmaceutical bulletin 1996;44(6):1181-7.
1996: Yang-Chang Wu; Y C Hung; Fang-Rong Chang; M Cosentino; H K Wang; Kuo-Hsiung Lee
Identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa.
Journal of natural products 1996;59(6):635-7.
1996: Hui-Kang Wang; Kenneth F Bastow; L Mark Cosentino; Kuo-Hsiung Lee
Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones.
Journal of medicinal chemistry 1996;39(10):1975-80.
1996: I O Anyanwutaku; X Guo; H X Chen; Z Ji; Kuo-Hsiung Lee; Yung-Chi Cheng
Activities of novel nonglycosidic epipodophyllotoxins in etoposide-sensitive and -resistant variants of human KB cells, P-388 cells, and in vivo multidrug-resistant murine leukemia cells.
Molecular pharmacology 1996;49(4):721-6.
1996: Sheng-Chu Kuo; T Ibuka; Li-Jiau Huang; J C Lien; S R Yean; S C Huang; D Lednicer; Susan L Morris-Natschke; Kuo-Hsiung Lee
Synthesis and cytotoxicity of 1,2-disubstituted naphth[2,3-d]imidazole-4,9-diones and related compounds.
Journal of medicinal chemistry 1996;39(7):1447-51.
1996: SJ Cho; Yoshiki Kashiwada; Kenneth F Bastow; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.
Journal of medicinal chemistry 1996;39(7):1396-402.
1996: SJ Cho; Alexander Tropsha; M Suffness; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4'-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach.
Journal of medicinal chemistry 1996;39(7):1383-95.
1996: Yoshiki Kashiwada; F Hashimoto; L Mark Cosentino; C H Chen; P E Garrett; Kuo-Hsiung Lee
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
Journal of medicinal chemistry 1996;39(5):1016-7.
1996: E Hamel; C M Lin; J Plowman; H K Wang; Kuo-Hsiung Lee; KD Paull
Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin.
Biochemical pharmacology 1996;51(1):53-9.
1995: K Imamura; Narihiko Fukamiya; M Nakamura; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee
Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica.
Journal of natural products 1995;58(12):1915-9.
1995: Yueh-Hsiung Kuo; C F Chen; L M Kuo; M L King; Chieh-Fu Chen; Kuo-Hsiung Lee
Celahinine A, a new sesquiterpene pyridine alkaloid from Celastrus hindsii.
Journal of natural products 1995;58(11):1735-8.
1995: K Chen; Qian Shi; Toshihiro Fujioka; T Nakano; C Q Hu; J Q Jin; R E Kilkuskie; Kuo-Hsiung Lee
Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.
Bioorganic & medicinal chemistry 1995;3(10):1345-8.
1995: Takao Konoshima; I Yasuda; Yoshiki Kashiwada; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents, 21. Triterpenoid saponins as anti-HIV principles from fruits of Gleditsia japonica and Gymnocladus chinensis, and a structure-activity correlation.
Journal of natural products 1995;58(9):1372-7.
1995: L Xie; J X Xie; Yoshiki Kashiwada; L Mark Cosentino; S H Liu; R B Pai; Yung-Chi Cheng; Kuo-Hsiung Lee
Anti-AIDS (acquired immune deficiency syndrome) agents. 17. New brominated hexahydroxybiphenyl derivatives as potent anti-HIV agents.
Journal of medicinal chemistry 1995;38(16):3003-8.
1995: Masayoshi Okano; Narihiko Fukamiya; Kiyoshi Tagahara; Harukuni Tokuda; A Iwashima; H Nishino; Kuo-Hsiung Lee
Inhibitory effects of quassinoids on Epstein-Barr virus activation.
Cancer letters 1995;94(2):139-46.
1995: S Ohnishi; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee
Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica.
Journal of natural products 1995;58(7):1032-8.
1995: S X Zhang; K Chen; X J Liu; D C Zhang; T W Tao-Wiedmann; S L Leu; Andrew T McPhail; Kuo-Hsiung Lee
The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum.
Journal of natural products 1995;58(4):540-7.
1995: Yoshiki Kashiwada; Toshihiro Fujioka; Kunihide Mihashi; N Marubayashi; K Mizuki; Ih-Sheng Chen; Kuo-Hsiung Lee
Antitumor agents, 157. Absolute structures of cumingianosides A-F, antileukemic triterpene glucosides, and structures of the hydrolysates of cumingianoside A.
Journal of natural products 1995;58(4):495-503.
1995: Yoshiki Kashiwada; M Nishizawa; T Yamagishi; T Tanaka; G Nonaka; L Mark Cosentino; J V Snider; Kuo-Hsiung Lee
Anti-AIDS agents, 18. Sodium and potassium salts of caffeic acid tetramers from Arnebia euchroma as anti-HIV agents.
Journal of natural products 1995;58(3):392-400.
1994: Kenneth F Bastow; M Itoigawa; H Furukawa; Yoshiki Kashiwada; I D Bori; L M Ballas; Kuo-Hsiung Lee
Antiproliferative actions of 7-substituted 1,3-dihydroxyacridones; possible involvement of DNA topoisomerase II and protein kinase C as biochemical targets.
Bioorganic & medicinal chemistry 1994;2(12):1403-11.
1994: Hui-Kang Wang; S Y Liu; K M Hwang; G Taylor; Kuo-Hsiung Lee
Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I.
Bioorganic & medicinal chemistry 1994;2(12):1397-402.
1994: L Huang; Yoshiki Kashiwada; L Mark Cosentino; S Fan; C H Chen; Andrew T McPhail; Toshihiro Fujioka; Kunihide Mihashi; Kuo-Hsiung Lee
Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs.
Journal of medicinal chemistry 1994;37(23):3947-55.
1994: S Zhang; C Tung-Ling Lee; Yoshiki Kashiwada; K Chen; D C Zhang; Kuo-Hsiung Lee
Yunantaxusin A, a new 11(15-->1)-abeo-taxane from Taxus yunnanensis.
Journal of natural products 1994;57(11):1580-3.
1994: T T Lee; Yoshiki Kashiwada; L Huang; J Snider; M Cosentino; Kuo-Hsiung Lee
Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.
Bioorganic & medicinal chemistry 1994;2(10):1051-6.
1994: L Li; Hui-Kang Wang; Sheng-Chu Kuo; T S Wu; Anthony B Mauger; C M Lin; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.
Journal of medicinal chemistry 1994;37(20):3400-7.
1994: Y L Zhang; Alexander Tropsha; Andrew T McPhail; Kuo-Hsiung Lee
Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy.
Journal of medicinal chemistry 1994;37(10):1460-4.
1994: L Li; Hui-Kang Wang; Sheng-Chu Kuo; T S Wu; D Lednicer; C M Lin; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 1994;37(8):1126-35.
1994: Y L Zhang; X Guo; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 148. Synthesis and biological evaluation of novel 4 beta-amino derivatives of etoposide with better pharmacological profiles.
Journal of medicinal chemistry 1994;37(4):446-52.
1994: Yueh-Hsiung Kuo; M L King; Chieh-Fu Chen; H Y Chen; C H Chen; K Chen; Kuo-Hsiung Lee
Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F.
Journal of natural products 1994;57(2):263-9.
1994: Toshihiro Fujioka; Yoshiki Kashiwada; R E Kilkuskie; L Mark Cosentino; L M Ballas; J B Jiang; W P Janzen; I S Chen; Kuo-Hsiung Lee
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.
Journal of natural products 1994;57(2):243-7.
1994: X M Zhou; K J Lee; J Cheng; S S Wu; H X Chen; X Guo; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 144. New gamma-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1994;37(2):287-92.
1994: Yoshiki Kashiwada; L Huang; L M Ballas; J B Jiang; W P Janzen; Kuo-Hsiung Lee
New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.
Journal of medicinal chemistry 1994;37(1):195-200.
1994: C Q Hu; K Chen; Qian Shi; R E Kilkuskie; Yung-Chi Cheng; Kuo-Hsiung Lee
Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.
Journal of natural products 1994;57(1):42-51.
1993: B R Huang; Kuo-Hsiung Lee; T L Tseng; H M Wang; C F Chen; Cherng-Chyi Tzeng
Synthetic and cytotoxic studies of alpha-methylene-gamma-butyrolactone bearing pyrimidines.
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences 1993;9(12):707-11.
1993: K Imamura; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee
Bruceanols D, E, and F three new cytotoxic quassinoids from Brucea antidysenterica.
Journal of natural products 1993;56(12):2091-7.
1993: Yoshiki Kashiwada; D C Zhang; Y P Chen; C M Cheng; H T Chen; H C Chang; J J Chang; Kuo-Hsiung Lee
Antitumor agents, 145. Cytotoxic asprellic acids A and C and asprellic acid B. new p-coumaroyl triterpenes, from Ilex asprella.
Journal of natural products 1993;56(12):2077-82.
1993: Takao Konoshima; Midori Takasaki; Mutsuo Kozuka; M Haruna; K Ito; J R Estes; Kuo-Hsiung Lee
Constituents of rosaceous plants. I. Structure of new triterpenoids from Cowania mexicana.
Chemical & pharmaceutical bulletin 1993;41(9):1612-5.
1993: Kenneth F Bastow; H Tatematsu; L Sun; Y Fukushima; Kuo-Hsiung Lee
Synthesis and biological evaluation of tetrademethyl isocolchicine derivatives as inhibitors of DNA topoisomerase action in vitro.
Bioorganic & medicinal chemistry 1993;1(3):227-34.
1993: H Y Li; N J Sun; Yoshiki Kashiwada; L Sun; J V Snider; L Mark Cosentino; Kuo-Hsiung Lee
Anti-AIDS agents, 9. Suberosol, a new C31 lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa.
Journal of natural products 1993;56(7):1130-3.
1993: G F Chen; Z L Li; D J Pan; C M Tang; X He; G Y Xu; K Chen; Kuo-Hsiung Lee
The isolation and structural elucidation of four novel triterpene lactones, pseudolarolides A, B, C, and D, from Pseudolarix kaempferi.
Journal of natural products 1993;56(7):1114-22.
1993: Kenneth F Bastow; I D Bori; Y Fukushima; Yoshiki Kashiwada; T Tanaka; G Nonaka; I Nishioka; Kuo-Hsiung Lee
Inhibition of DNA topoisomerases by sanguiin H-6, a cytotoxic dimeric ellagitannin from Sanguisorba officinalis.
Planta medica 1993;59(3):240-5.
1993: Takao Konoshima; H Terada; M Kokumai; Mutsuo Kozuka; Harukuni Tokuda; J R Estes; L Li; Hui-Kang Wang; Kuo-Hsiung Lee
Studies on inhibitors of skin tumor promotion, XII. Rotenoids from Amorpha fruticosa.
Journal of natural products 1993;56(6):843-8.
1993: L Sun; Ernest Hamel; C M Lin; S B Hastie; A Pyluck; Kuo-Hsiung Lee
Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.
Journal of medicinal chemistry 1993;36(10):1474-9.
1993: Yoshiki Kashiwada; G Nonaka; I Nishioka; K J Lee; I Bori; Y Fukushima; Kenneth F Bastow; Kuo-Hsiung Lee
Tannins as potent inhibitors of DNA topoisomerase II in vitro.
Journal of pharmaceutical sciences 1993;82(5):487-92.
1993: L Sun; Andrew T McPhail; Ernest Hamel; C M Lin; S B Hastie; J J Chang; Kuo-Hsiung Lee
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.
Journal of medicinal chemistry 1993;36(5):544-51.
1993: Z Q Wang; Y C Shen; H X Chen; J Y Chang; X Guo; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 126. Novel 4 beta-substituted anilino derivatives of 3',4'-O,O-didemethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Pharmaceutical research 1993;10(3):343-50.
1993: X M Zhou; Z Q Wang; H X Chen; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 125. New 4 beta-benzoylamino derivatives of 4'-O-demethyl-4-desoxypodophyllotoxin and 4 beta-benzoyl derivatives of 4'-O-demethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Pharmaceutical research 1993;10(2):214-9.
1992: Qian Shi; K Chen; Toshihiro Fujioka; Yoshiki Kashiwada; J J Chang; Mutsuo Kozuka; J R Estes; Andrew T McPhail; D R McPhail; Kuo-Hsiung Lee
Antitumor agents, 135. Structure and stereochemistry of polacandrin, a new cytotoxic triterpene from Polanisia dodecandra.
Journal of natural products 1992;55(10):1488-97.
1992: Yoshiki Kashiwada; G Nonaka; I Nishioka; J J Chang; Kuo-Hsiung Lee
Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents.
Journal of natural products 1992;55(8):1033-43.
1992: Y L Zhang; Y C Shen; Z Q Wang; H X Chen; X Guo; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Journal of natural products 1992;55(8):1100-11.
1992: Hui-Kang Wang; J X Xie; J J Chang; K M Hwang; S Y Liu; L M Ballas; J B Jiang; Kuo-Hsiung Lee
Antitumor agents. 134. New shiraiachrome-A- and calphostin-C-related perylene derivatives as cytotoxic and antiviral agents and inhibitors of protein kinase C.
Journal of medicinal chemistry 1992;35(15):2717-21.
1992: Narihiko Fukamiya; Masayoshi Okano; M Miyamoto; Kiyoshi Tagahara; Kuo-Hsiung Lee
Antitumor agents, 127. Bruceoside C, a new cytotoxic quassinoid glucoside, and related compounds from Brucea javanica.
Journal of natural products 1992;55(4):468-75.
1992: Z Q Wang; H Hu; H X Chen; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1992;35(5):871-7.
1992: H Hu; Z Q Wang; S Y Liu; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins.
Journal of medicinal chemistry 1992;35(5):866-71.
1992: A A Grippo; Iris H Hall; H Kiyokawa; O Muraoka; Y C Shen; Kuo-Hsiung Lee
The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells.
Drug design and discovery 1992;8(3):191-206.
1992: K Chen; Q A Shi; Toshihiro Fujioka; D C Zhang; C Q Hu; J Q Jin; R E Kilkuskie; Kuo-Hsiung Lee
Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.
Journal of natural products 1992;55(1):88-92.
1991: H Sakurai; T Miki; Y Imakura; M Shibuya; Kuo-Hsiung Lee
Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds.
Molecular pharmacology 1991;40(6):965-73.
1991: X M Zhou; Z Q Wang; J Y Chang; H X Chen; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1991;34(12):3346-50.
1991: A A Grippo; SD Wyrick; Kuo-Hsiung Lee; Robert Shrewsbury; Iris H Hall
Disposition of an antineoplastic sesquiterpene lactone, [3H]-plenolin, in BDF1 mice.
Planta medica 1991;57(4):309-14.
1991: Y C Wu; Chang-Yih Duh; F R Chang; G Y Chang; Shang-Kwei Wang; J J Chang; D R McPhail; Andrew T McPhail; Kuo-Hsiung Lee
The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon.
Journal of natural products 1991;54(4):1077-81.
1991: T Matsuzaki; Narihiko Fukamiya; Masayoshi Okano; T Fujita; Kiyoshi Tagahara; Kuo-Hsiung Lee
Picrasinoside H, a new quassinoid glucoside, and related compounds from the stem wood of Picrasma ailanthoides.
Journal of natural products 1991;54(3):844-8.
1991: T S Wu; Y M Lin; M Haruna; D J Pan; T Shingu; Y P Chen; H Y Hsu; T Nakano; Kuo-Hsiung Lee
Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui.
Journal of natural products 1991;54(3):823-9.
1991: H Tatematsu; M Mori; T H Yang; J J Chang; T T Lee; Kuo-Hsiung Lee
Cytotoxic principles of Securinega virosa: virosecurinine and viroallosecurinine and related derivatives.
Journal of pharmaceutical sciences 1991;80(4):325-7.
1991: J Y Chang; F S Han; S Y Liu; Z Q Wang; Kuo-Hsiung Lee; Yung-Chi Cheng
Effect of 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin on human DNA topoisomerase II, tubulin polymerization, KB cells, and their resistant variants.
Cancer research 1991;51(7):1755-9.
1991: H Tatematsu; R E Kilkuskie; A J Corrigan; A J Bodner; Kuo-Hsiung Lee
Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells.
Journal of natural products 1991;54(2):632-7.
1991: D E Chapman; David Holbrook; Stephen G Chaney; Iris H Hall; Kuo-Hsiung Lee
In vivo and in vitro effects of helenalin on mouse hepatic microsomal cytochrome P450.
Biochemical pharmacology 1991;41(2):229-35.
1991: Iris H Hall; Kuo-Hsiung Lee
The effects of alpha-methylene-gamma-lactone purines and pyrimidines on L1210 lymphoid leukemia nucleic acid metabolism.
Anticancer research 1991;11(1):337-42.
1990: Iris H Hall; A A Grippo; David Holbrook; J J Chang; L M Yang; Stephen G Chaney; Kuo-Hsiung Lee
Renal, hepatic, cardiac and thymic acute toxicity afforded by bis(helenalinyl)malonate in BDF1 mice.
Toxicology 1990;64(2):205-16.
1990: T Toyota; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; J J Chang; Kuo-Hsiung Lee
Antitumor agents, 118. The isolation and characterization of bruceanic acid A, its methyl ester, and the new bruceanic acids B, C, and D, from Brucea antidysenterica.
Journal of natural products 1990;53(6):1526-32.
1990: Z Q Wang; Yueh-Hsiung Kuo; D Schnur; J P Bowen; S Y Liu; F S Han; J Y Chang; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1990;33(9):2660-6.
1990: D J Pan; Z L Li; C Q Hu; K Chen; J J Chang; Kuo-Hsiung Lee
The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.
Planta medica 1990;56(4):383-5.
1990: C Q Hu; J J Chang; Kuo-Hsiung Lee
Antitumor agents, 115. Seselidiol, a new cytotoxic polyacetylene from Seseli mairei.
Journal of natural products 1990;53(4):932-5.
1990: H Nozaki; Y Matsuura; S Hirono; R Kasai; J J Chang; Kuo-Hsiung Lee
Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia.
Journal of natural products 1990;53(4):1039-41.
1990: Kuo-Hsiung Lee; S A Beers; M Mori; Z Q Wang; Yueh-Hsiung Kuo; L Li; S Y Liu; J Y Chang; F S Han; Yung-Chi Cheng
Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Journal of medicinal chemistry 1990;33(5):1364-8.
1990: G Nonaka; I Nishioka; M Nishizawa; T Yamagishi; Yoshiki Kashiwada; G E Dutschman; A J Bodner; R E Kilkuskie; Yung-Chi Cheng; Kuo-Hsiung Lee
Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
Journal of natural products 1990;53(3):587-95.
1990: Yueh-Hsiung Kuo; C H Chen; L M Kuo; M L King; T S Wu; M Haruna; Kuo-Hsiung Lee
Antitumor agents, 112. Emarginatine B, a novel potent cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata.
Journal of natural products 1990;53(2):422-8.
1989: Iris H Hall; A A Grippo; David Holbrook; G Roberts; H C Lin; H L Kim; Kuo-Hsiung Lee
Role of thiol agents in protecting against the toxicity of helenalin in tumor-bearing mice.
Planta medica 1989;55(6):513-7.
1989: D E Chapman; David Holbrook; Stephen G Chaney; Iris H Hall; Kuo-Hsiung Lee
In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone.
Biochemical pharmacology 1989;38(22):3913-23.
1989: T S Wu; M L Wang; T T Jong; Andrew T McPhail; D R McPhail; Kuo-Hsiung Lee
X-ray crystal structure of acrovestone, a cytotoxic principle from Acronychia pedunculata.
Journal of natural products 1989;52(6):1284-9.
1989: W B Parker; M Nishizawa; M H Fisher; N Ye; Kuo-Hsiung Lee; Yung-Chi Cheng
Characterization of a novel inhibitor of human DNA polymerases: 3,4,5-tri-O-galloylquinic acid.
Biochemical pharmacology 1989;38(21):3759-65.
1989: T Yamagishi; M Haruna; X Z Yan; J J Chang; Kuo-Hsiung Lee
Antitumor agents, 110. Bryophyllin B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum.
Journal of natural products 1989;52(5):1071-9.
1989: S Y Liu; B D Hwang; M Haruna; Y Imakura; Kuo-Hsiung Lee; Yung-Chi Cheng
Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.
Molecular pharmacology 1989;36(1):78-82.
1989: M Nishizawa; T Yamagishi; G E Dutschman; W B Parker; A J Bodner; R E Kilkuskie; Yung-Chi Cheng; Kuo-Hsiung Lee
Anti-AIDS agents, 1. Isolation and characterization of four new tetragalloylquinic acids as a new class of HIV reverse transcriptase inhibitors from tannic acid.
Journal of natural products 1989;52(4):762-8.
1989: Kuo-Hsiung Lee; Y Imakura; M Haruna; S A Beers; L S Thurston; H J Dai; C H Chen; S Y Liu; Yung-Chi Cheng
Antitumor agents, 107. New cytotoxic 4-alkylamino analogues of 4'-demethyl-epipodophyllotoxin as inhibitors of human DNA topoisomerase II.
Journal of natural products 1989;52(3):606-13.
1989: Masayoshi Okano; Narihiko Fukamiya; T Toyota; Kiyoshi Tagahara; Kuo-Hsiung Lee
Antitumor agents, 104. Isolation of yadanziosides M and P from Brucea antidysenterica and identification of bruceantinoside B as a mixture of yadanzioside P and bruceantinoside C.
Journal of natural products 1989;52(2):398-401.
1989: L S Thurston; Y Imakura; M Haruna; D H Li; Z C Liu; S Y Liu; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 100. Inhibition of human DNA topoisomerase II by cytotoxic ether and ester derivatives of podophyllotoxin and alpha-peltatin.
Journal of medicinal chemistry 1989;32(3):604-8.
1988: S A Beers; Y Imakura; H J Dai; D H Li; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents, 99. Synthetic ring C aromatized podophyllotoxin analogues as potential inhibitors of human DNA topoisomerase II.
Journal of natural products 1988;51(5):901-5.
1988: Kuo-Hsiung Lee; Y M Lin; T S Wu; D C Zhang; T Yamagishi; T Hayashi; Iris H Hall; J J Chang; R Y Wu; T H Yang
The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives.
Planta medica 1988;54(4):308-11.
1988: T Yamagishi; X Z Yan; R Y Wu; D R McPhail; Andrew T McPhail; Kuo-Hsiung Lee
Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum.
Chemical & pharmaceutical bulletin 1988;36(4):1615-7.
1988: T Yokoi; L M Yang; T Yokoi; R Y Wu; Kuo-Hsiung Lee
Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. III. Structure-activity relationships.
The Journal of antibiotics 1988;41(4):494-501.
1988: L M Yang; R Y Wu; Andrew T McPhail; T Yokoi; Kuo-Hsiung Lee
Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. II. Structural determination and total synthesis.
The Journal of antibiotics 1988;41(4):488-93.
1988: R Y Wu; L M Yang; T Yokoi; Kuo-Hsiung Lee
Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. I. The producing organism, fermentation, isolation and biological properties.
The Journal of antibiotics 1988;41(4):481-7.
1988: Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; T Aratani; Kuo-Hsiung Lee
Antitumor agents, 93. Bruceanol C, a new cytotoxic quassinoid from Brucea antidysenterica.
Journal of natural products 1988;51(2):349-52.
1988: D E Chapman; G B Roberts; D J Reynolds; A A Grippo; David Holbrook; Iris H Hall; Stephen G Chaney; J Chang; Kuo-Hsiung Lee
Acute toxicity of helenalin in BDF1 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1988;10(2):302-12.
1988: W L Williams; Iris H Hall; A A Grippo; C B Oswald; Kuo-Hsiung Lee; David Holbrook; Stephen G Chaney
Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo.
Journal of pharmaceutical sciences 1988;77(2):178-84.
1988: Iris H Hall; W L Williams; A A Grippo; Kuo-Hsiung Lee; David Holbrook; Stephen G Chaney
Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia cells in culture by sesquiterpene lactones.
Anticancer research 1988;8(1):33-42.
1987: Iris H Hall; A A Grippo; Kuo-Hsiung Lee; Stephen G Chaney; David Holbrook
Effect of helenalin and bis(helenalinyl)malonate on nucleic acid and protein synthesis in human KB carcinoma cells.
Pharmaceutical research 1987;4(6):509-14.
1987: J D Page; Stephen G Chaney; Iris H Hall; Kuo-Hsiung Lee; David Holbrook
Inhibition of inosine monophosphate dehydrogenase by sesquiterpene lactones.
Biochimica et biophysica acta 1987;926(2):186-94.
1987: T Hayashi; F T Smith; Kuo-Hsiung Lee
Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships.
Journal of medicinal chemistry 1987;30(11):2005-8.
1987: Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; T Aratani; Y Muramoto; Kuo-Hsiung Lee
Antitumor agents, 90. Bruceantinoside C, a new cytotoxic quassinoid glycoside from Brucea antidysenterica.
Journal of natural products 1987;50(6):1075-9.
1987: Kuo-Hsiung Lee; S Tani; Y Imakura
Antimalarial agents, 4. Synthesis of a brusatol analog and biological activity of brusatol-related compounds.
Journal of natural products 1987;50(5):847-51.
1987: Y Zhao; Iris H Hall; C B Oswald; T Yokoi; Kuo-Hsiung Lee
Antimalarial agents. III. Mechanism of action of artesunate against Plasmodium berghei infection.
Chemical & pharmaceutical bulletin 1987;35(5):2052-61.
1987: Iris H Hall; Kuo-Hsiung Lee; H C Sykes
Anti-inflammatory agents; IV. Structure activity relationships of sesquiterpene lactone esters derived from helenalin.
Planta medica 1987;53(2):153-6.
1987: Narihiko Fukamiya; M Okano; T Aratani; K Negoro; Y M Lin; Kuo-Hsiung Lee
Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives.
Planta medica 1987;53(2):140-3.
1987: Kuo-Hsiung Lee; G K Rice; Iris H Hall; V Amarnath
Antitumor agents. 86. Synthesis and cytotoxicity of alpha-methylene-gamma-lactone-bearing purines.
Journal of medicinal chemistry 1987;30(3):586-8.
1986: T Konoshima; Kuo-Hsiung Lee
Antitumor agents, 85. Cicutoxin, an antileukemic principle from Cicuta maculata, and the cytotoxicity of the related derivatives.
Journal of natural products 1986;49(6):1117-21.
1986: L S Thurston; H Irie; S Tani; F S Han; Z C Liu; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and alpha-peltatin analogues.
Journal of medicinal chemistry 1986;29(8):1547-50.
1986: T Konoshima; Kuo-Hsiung Lee
Antitumor agents, 82. Cytotoxic sapogenols from Aesculus hippocastanum.
Journal of natural products 1986;49(4):650-6.
1986: Narihiko Fukamiya; Masayoshi Okano; T Aratani; K Negoro; A T McPhail; M Ju-ichi; Kuo-Hsiung Lee
Antitumor agents, 79. Cytotoxic antileukemic alkaloids from Brucea antidysenterica.
Journal of natural products 1986;49(3):428-34.
1986: N Fukamiya; Kuo-Hsiung Lee
Antitumor agents, 81. Justicidin-A and diphyllin, two cytotoxic principles from Justicia procumbens.
Journal of natural products 1986;49(2):348-50.
1986: Iris H Hall; Y F Liou; C B Oswald; Kuo-Hsiung Lee
The effects of genkwadaphnin and gnidilatidin on the growth of P-388, L-1210 leukemia and KB carcinoma cells in vitro.
European journal of cancer & clinical oncology 1986;22(1):45-52.
1986: Y Zhao; W K Hanton; Kuo-Hsiung Lee
Antimalarial agents, 2. Artesunate, an inhibitor of cytochrome oxidase activity in Plasmodium berghei.
Journal of natural products 1986;49(1):139-42.
1985: Y M Lin; M Juichi; R Y Wu; Kuo-Hsiung Lee
Antitumor Agents LXIX. Alkaloids of Ochrosia acuminata1.
Planta medica 1985;51(6):545-6.
1985: Y M Lin; M Juichi; R Y Wu; Kuo-Hsiung Lee
Antitumor agents. LXIX. Alkaloids of Ochrosia acuminata.
Planta medica 1985;(6):545-6.
1985: Masayoshi Okano; Narihiko Fukamiya; T Aratani; M Juichi; Kuo-Hsiung Lee
Antitumor agents, 74. Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica.
Journal of natural products 1985;48(6):972-5.
1985: P Chang; Kuo-Hsiung Lee
Antitumor agents, 75. Synthesis of cytotoxic anthraquinones digiferruginol and morindaparvin-B.
Journal of natural products 1985;48(6):948-51.
1985: Iris H Hall; W L Williams; Stephen G Chaney; C J Gilbert; David Holbrook; O Muraoka; H Kiyokawa; Kuo-Hsiung Lee
Antitumor agents 68: effects of a series of helenalin derivatives on P-388 lymphocytic leukemia nucleic acid and protein synthesis.
Journal of pharmaceutical sciences 1985;74(3):250-4.
1985: M Haruna; G Rice; Kuo-Hsiung Lee
Antitumor agents, 71. Nudaphantin, a new cytotoxic germacranolide, and elephantopin from Elephantopus nudatus.
Journal of natural products 1985;48(1):93-6.
1984: W L Williams; Stephen G Chaney; Iris H Hall; Kuo-Hsiung Lee
Indirect inactivation of rabbit reticulocyte initiation factor eIF-2 by helenalin and bis(helenalinyl) malonate.
Biochemistry 1984;23(23):5637-44.
1984: Kuo-Hsiung Lee; N Hayashi; M Okano; H Nozaki; M Ju-Ichi
Antitumor agents, 65. Brusatol and cleomiscosin-A, antileukemic principles from Brucea javanica.
Journal of natural products 1984;47(3):550-1.
1984: W Willingham; R T Considine; Stephen G Chaney; Kuo-Hsiung Lee; Iris H Hall
Reversibility of protein synthesis inhibition by quassinoid antineoplastic agents in a rabbit reticulocyte system.
Biochemical pharmacology 1984;33(2):330-3.
1984: Stephen G Chaney; W L Williams; W Willingham; R T Considine; Iris H Hall; Kuo-Hsiung Lee
Inhibition of protein synthesis initiation factors by naturally occurring sulfhydryl reactive reagents.
Current topics in cellular regulation 1984;24():251-60.
1983: Iris H Hall; Kuo-Hsiung Lee; Y Imakura; M Okano; A Johnson
Anti-inflammatory agents III: Structure-activity relationships of brusatol and related quassinoids.
Journal of pharmaceutical sciences 1983;72(11):1282-4.
1983: R K Levy; Iris H Hall; Kuo-Hsiung Lee
Antitumor agents LXII: synthesis and biological evaluation of podophyllotoxin esters and related derivatives.
Journal of pharmaceutical sciences 1983;72(10):1158-61.
1983: Iris H Hall; Kuo-Hsiung Lee; Y Imakura; D Sims
Antitumor agents LXIII: the effects of microlenin on nucleic acid and protein syntheses of Ehrlich ascites cells.
Journal of pharmaceutical sciences 1983;72(9):1008-11.
1983: W L Williams; Stephen G Chaney; W Willingham; R T Considine; Iris H Hall; Kuo-Hsiung Lee
Selective inactivation of rabbit reticulocyte initiation factor eIF-3 by helenalin.
Biochimica et biophysica acta 1983;740(2):152-62.
1983: Iris H Hall; Y F Liou; Kuo-Hsiung Lee; Stephen G Chaney; W Willingham
Antitumor agents LIX: effects of quassinoids on protein synthesis of a number of murine tumors and normal cells.
Journal of pharmaceutical sciences 1983;72(6):626-30.
1983: R T Considine; W Willingham; Stephen G Chaney; S Wyrick; Iris H Hall; Kuo-Hsiung Lee
Structure-activity relationships for binding and inactivation of rabbit reticulocyte ribosomes by quassinoid antineoplastic agents.
European journal of biochemistry / FEBS 1983;132(1):157-63.
1983: Y F Liou; Iris H Hall; Kuo-Hsiung Lee; W L Williams; Stephen G Chaney
Investigation of sesquiterpene lactones as protein synthesis inhibitors of P-388 lymphocytic leukemia cells.
Biochimica et biophysica acta 1983;739(2):190-6.
1982: Y F Liou; Iris H Hall; Kuo-Hsiung Lee
Antitumor agents LVI: the protein synthesis inhibition by genkwadaphnin and yuanhuacine of P-388 lymphocytic leukemia cells.
Journal of pharmaceutical sciences 1982;71(12):1340-4.
1982: Iris H Hall; R Kasai; R Y Wu; K Tagahara; Kuo-Hsiung Lee
Antitumor agents LV: Effects of genkwadaphnin and yuanhuacine on nucleic acid synthesis of P-388 lymphocytic leukemia cells.
Journal of pharmaceutical sciences 1982;71(11):1263-7.
1982: Y F Liou; Iris H Hall; Kuo-Hsiung Lee
Antitumor agents LIV: The effects of daphnoretin on in vitro protein synthesis of Ehrlich ascites carcinoma cells and other tissues.
Journal of pharmaceutical sciences 1982;71(7):745-9.
1982: Iris H Hall; K Tagahara; Kuo-Hsiung Lee
Antitumor agents LIII: The effects of daphnoretin on nucleic acid and protein synthesis of Ehrlich ascites tumor cells.
Journal of pharmaceutical sciences 1982;71(7):741-4.
1982: Iris H Hall; Y F Liou; Kuo-Hsiung Lee
Antitumor agents LII: The effects of molephantinin on nucleic acid and protein synthesis of Ehrlich ascites cells.
Journal of pharmaceutical sciences 1982;71(6):687-90.
1982: R Kasai; T Shingu; R Y Wu; Iris H Hall; Kuo-Hsiung Lee
Antitumor agents 57. The isolation and structural elucidation of microhelenin-E, a new antileukemic nor-pseudoguaianolide, and microhelenin-F from Helenium microcephalum.
Journal of natural products 1982;45(3):317-20.
1982: Y F Liou; Iris H Hall; M Okano; Kuo-Hsiung Lee; Stephen G Chaney
Antitumor agents XLVIII: Structure-activity relationships of quassinoids as in vitro protein synthesis inhibitors of P-388 lymphocytic leukemia tumor cell metabolism.
Journal of pharmaceutical sciences 1982;71(4):430-5.
1982: P Chang; Kuo-Hsiung Lee; T Shingu; T Hirayama; Iris H Hall; H C Huang
Antitumor agents 50. 1 Morindaparvin-A, a new antileukemic anthraquinone, and alizarin-1-methyl ether from Morinda parvifolia, and the antileukemic activity of the related derivatives.
Journal of natural products 1982;45(2):206-10.
1982: Iris H Hall; Y F Liou; M Okano; Kuo-Hsiung Lee
Antitumor agents XLVI: In vitro effects of esters of brusatol, bisbrusatol, and related compounds on nucleic acid and protein synthesis of P-388 lymphocytic leukemia cells.
Journal of pharmaceutical sciences 1982;71(3):345-8.
1982: Kuo-Hsiung Lee; M Okano; Iris H Hall; D A Brent; B Soltmann
Antitumor agents XLV: Bisbrusatolyl and brusatolyl esters and related compounds as novel potent antileukemic agents.
Journal of pharmaceutical sciences 1982;71(3):338-45.
1982: Iris H Hall; Y F Liou; Kuo-Hsiung Lee; M Okano; Stephen G Chaney
Antitumor agents XLVII: The effects of bisbrusatolyl malonate on P-388 lymphocytic leukemia cell metabolism.
Journal of pharmaceutical sciences 1982;71(2):257-62.
1981: Iris H Hall; Kuo-Hsiung Lee; M Okano; D Sims; T Ibuka; Y F Liou; Y Imakura
Antitumor agents XLII: Comparison of antileukemic activity of helenalin, brusatol, and bruceantin and their esters on different strains of P-388 lymphocytic leukemic cells.
Journal of pharmaceutical sciences 1981;70(10):1147-50.
1981: Kuo-Hsiung Lee; K Tagahara; H Suzuki; R Y Wu; M Haruna; Iris H Hall; H C Huang; K Ito; T Iida; J S Lai
Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica.
Journal of natural products 1981;44(5):530-5.
1981: Kuo-Hsiung Lee; T Ibuka; D Sims; O Muraoka; H Kiyokawa; Iris H Hall; H L Kim
Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents.
Journal of medicinal chemistry 1981;24(8):924-7.
1981: W Willingham; E A Stafford; S H Reynolds; Stephen G Chaney; Kuo-Hsiung Lee; M Okano; Iris H Hall
Mechanism of eukaryotic protein synthesis inhibition by brusatol.
Biochimica et biophysica acta 1981;654(2):169-74.
1981: M Okano; Kuo-Hsiung Lee; Iris H Hall
Antitumor agents. 39. Bruceantinoside-A and -B, novel antileukemic quassinoid glucosides from Brucea antidysenterica.
Journal of natural products 1981;44(4):470-4.
1980: Kuo-Hsiung Lee; T Ibuka; H Furukawa; Mutsuo Kozuka; R Y Wu; Iris H Hall; H C Huang
Antitumor agents XXXVIII: Isolation and structural elucidation of novel germacranolides and triterpenes from Elephantopus mollis.
Journal of pharmaceutical sciences 1980;69(9):1050-6.
1980: Y Imakura; Kuo-Hsiung Lee; D Sims; R Y Wu; Iris H Hall; H Furukawa; M Itoigawa; K Yonaha
Antitumor agents XXXVI: Structural elucidation of sesquiterpene lactones microhelenins-A, B, and C, microlenin acetate, and plenolin from Helenium microcephalum.
Journal of pharmaceutical sciences 1980;69(9):1044-9.
1980: Iris H Hall; Kuo-Hsiung Lee; C O Starnes; O Muraoka; Y Sumida; T G Waddell
Antihyperlipidemic activity of sesquiterpene lactones and related compounds.
Journal of pharmaceutical sciences 1980;69(6):694-7.
1980: Iris H Hall; C O Starnes; Kuo-Hsiung Lee; T G Waddell
Mode of action of sesquiterpene lactones as anti-inflammatory agents.
Journal of pharmaceutical sciences 1980;69(5):537-43.
1980: Iris H Hall; Kuo-Hsiung Lee; W L Williams; T Kimura; T Hirayama
Antitumor agents XLI: Effects of eupaformosanin on nucleic acid, protein, and anaerobic and aerobic glycolytic metabolism of Ehrlich ascites cells.
Journal of pharmaceutical sciences 1980;69(3):294-7.
1979: Iris H Hall; Kuo-Hsiung Lee; S A Eigebaly; Y Imakura; Y Sumida; R Y Wu
Antitumor agents. XXXIV: Mechanism of action of bruceoside A and brusatol on nucleic acid metabolism of P-388 lymphocytic leukemia cells.
Journal of pharmaceutical sciences 1979;68(7):883-7.
1979: S A Eigebaly; Iris H Hall; Kuo-Hsiung Lee; Y Sumida; Y Imakura; R Y Wu
Antitumor agents. XXXV: Effects of brusatol, bruceoside A, and bruceantin on P-388 lymphocytic leukemia cell respiration.
Journal of pharmaceutical sciences 1979;68(7):887-90.
1979: T G Waddell; A M Austin; J W Cochran; K G Gerhart; Iris H Hall; Kuo-Hsiung Lee
Antitumor agents: structure--activity relationships in tenulin series.
Journal of pharmaceutical sciences 1979;68(6):715-8.
1979: Iris H Hall; Kuo-Hsiung Lee; C O Starnes; Y Sumida; R Y Wu; T G Waddell; J W Cochran; K G Gerhart
Anti-inflammatory activity of sesquiterpene lactones and related compounds.
Journal of pharmaceutical sciences 1979;68(5):537-42.
1978: Iris H Hall; Kuo-Hsiung Lee; C O Starnes; S A Eigebaly; T Ibuka; Y S Wu; T Kimura; M Haruna
Antitumor agents XXX: Evaluation of alpha-methylene-gamma-lactone-containing agents for inhibition of tumor growth, respiration, and nucleic acid synthesis.
Journal of pharmaceutical sciences 1978;67(9):1235-9.
1978: Iris H Hall; Kuo-Hsiung Lee; S A Eigebaly
Antitumor agents XXIX: Effects of eupahyssopin on nucleic acid, protein, anaerobic, and aerobic metabolism of Ehrlich ascites tumor cells.
Journal of pharmaceutical sciences 1978;67(9):1232-5.
1978: Y Imakura; Kuo-Hsiung Lee; D Sims; Iris H Hall
Antitumor agents XXVIII: Structural elucidation of the novel antitumor sesquiterpene lactone, microlenin, from Helenium microcephalum.
Journal of pharmaceutical sciences 1978;67(9):1228-32.
1978: Kuo-Hsiung Lee; E C Mar; M Okamoto; Iris H Hall
Antitumor agents 32. Synthesis and antitumor activity of cyclopentenone derivatives related to helenalin.
Journal of medicinal chemistry 1978;21(8):819-22.
1978: Kuo-Hsiung Lee; T Ibuka; E C Mar; Iris H Hall
Antitumor agents. 31. Helenalin sym-dimethylethylenediamine reaction products and related derivatives.
Journal of medicinal chemistry 1978;21(7):698-701.
1978: Iris H Hall; Kuo-Hsiung Lee; S A Eigebaly
Antitumor agents XXVII: Effects of helenalin on anaerobic and aerobic metabolism of Ehrlich ascites cells.
Journal of pharmaceutical sciences 1978;67(4):552-4.
1977: Kuo-Hsiung Lee; M Haruna; H C Huang; B S Wu; Iris H Hall
Antitumor agents XXIII: Helenalin, and antitumor principle from Anaphalis morrisonicola HAY.
Journal of pharmaceutical sciences 1977;66(8):1194-5.
1977: Kuo-Hsiung Lee; Y S Wu; Iris H Hall
Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.
Journal of medicinal chemistry 1977;20(7):911-4.
1977: Kuo-Hsiung Lee; Iris H Hall; E C Mar; C O Starnes; Salwa Elgebaly; T G Waddell; R I HADGRAFT; C G Ruffner; I Weidner
Sesquiterpene antitumor agents: inhibitors of cellular metabolism.
Science (New York, N.Y.) 1977;196(4289):533-6.
1977: Iris H Hall; Kuo-Hsiung Lee; E C Mar; C O Starnes; T G Waddell
Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones.
Journal of medicinal chemistry 1977;20(3):333-7.
1976: Kuo-Hsiung Lee; Y Imakura; D Sims
Antitumor agents XVII; Structure and stereochemistry of microhelenin-A, a new antitumor sesquiterpene lactone from Helenium microcephalum.
Journal of pharmaceutical sciences 1976;65(9):1410-2.
1975: Kuo-Hsiung Lee; C M Cowherd; M T Wolo
Antitumor agents. XV: Deoxyelephantopin, an antitumor principle from Elephantopus carolinianus Willd.
Journal of pharmaceutical sciences 1975;64(9):1572-3.
1975: Kuo-Hsiung Lee; T Ibuka; S H Kim; B R Vestal; Iris H Hall; E S Huang
Antitumor agents. 16. Steroidal alpha-methylene-gamma-lactones.
Journal of medicinal chemistry 1975;18(8):812-7.
1975: Kuo-Hsiung Lee; T Ibuka; H C Huang
Letter: Antitumor agents XIV: molephantinin, a new potent antitumor sesquiterpene lactone from Elephantopus mollis.
Journal of pharmaceutical sciences 1975;64(6):1077-8.
1975: Kuo-Hsiung Lee; S H Kim; H Furukawa; C Piantadosi
Antitumor agents. 11. Synthesis and cytotoxic activity of epoxides of helenalin related derivatives.
Journal of medicinal chemistry 1975;18(1):59-63.
1974: Kuo-Hsiung Lee; T Ibuka; R Y Wu
Letter: Beta unsubstituted cyclopentenone, a structural requirement for antimicrobial and cytotoxic activities.
Chemical & pharmaceutical bulletin 1974;22(9):2206-8.
1974: Kuo-Hsiung Lee; S H Kim; C Piantadosi; Eng-Shang Huang; T A Geissman
Antitumor agents. 8. Synthesis and cytotoxic activity of O,O'-bis(acrylyl)-alpha,omega-alkanediols.
Journal of pharmaceutical sciences 1974;63(7):1162-3.
1973: Kuo-Hsiung Lee
Antitumor agents. V. Effect of epoxidation on cytotoxicity of helenalin-related derivatives.
Journal of pharmaceutical sciences 1973;62(6):1028-9.
1973: Kuo-Hsiung Lee; R Meck; C Piantadosi; Eng-Shang Huang
Antitumor agents. 4. Cytotoxicity and in vitro activity of helenalin esters and related derivatives.
Journal of medicinal chemistry 1973;16(3):299-301.
1972: Eng-Shang Huang; Kuo-Hsiung Lee; C Piantadosi; T A Geissman; Joseph S Pagano
Rapid microtiter method for cytotoxicity screening.
Journal of pharmaceutical sciences 1972;61(12):1960-2.
1972: Kuo-Hsiung Lee; H Furukawa
Antitumor agents. 3. Synthesis and cytotoxic activity of helenalin amine adducts and related derivatives.
Journal of medicinal chemistry 1972;15(6):609-11.
1972: Kuo-Hsiung Lee; H C Huang; E S Huang; H Furukawa
Antitumor agents. II. Eupatolide, a new cytotoxic principle from Eupatorium formosanum HAY.
Journal of pharmaceutical sciences 1972;61(4):629-31.
1972: Kuo-Hsiung Lee; D C Anuforo; E S Huang; C Piantadosi
Antitumor agents. I. Augustibalin, a new cytotoxic sesquiterpene lactone from Balduina angustifolia (Pursh.) Robins.
Journal of pharmaceutical sciences 1972;61(4):626-8.
1971: Kuo-Hsiung Lee; Eng-Shang Huang; C Piantadosi; Joseph S Pagano; T A Geissman
Cytotoxicity of sesquiterpene lactones.
Cancer research 1971;31(11):1649-54.
1970: C H Chen; T O Soine; Kuo-Hsiung Lee
Total synthesis of (plus or minus)-bisnorargemonine.
Journal of pharmaceutical sciences 1970;59(10):1529-30.
1969: Kuo-Hsiung Lee; T O Soine
Coumarins. X. Spectral studies on some linear furanocoumarins.
Journal of pharmaceutical sciences 1969;58(6):681-3.
1969: Kuo-Hsiung Lee; T O Soine
Coumarins. IX. Coumarins of Sphenosciadium capitellatum (A. Gray).
Journal of pharmaceutical sciences 1969;58(6):675-81.
1968: Kuo-Hsiung Lee; T O Soine
Synthesis of (+-)-norargemonine.
Journal of pharmaceutical sciences 1968;57(11):1922-6.
1968: Kuo-Hsiung Lee; T O Soine
Coumarins. VII. The coumarins of Lomatium nuttallii.
Journal of pharmaceutical sciences 1968;57(5):865-8.