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Rafael Casellas

Research Profile

Living Beings

Anatomy

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

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Molecular Sequence Data

Disorders

DNA Breaks, Double-Stranded

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Publications

TOP 3
Mila Jankovic; Kyong-Rim Kieffer-Kwon; Isaac Klein; Thiago Y Oliveira; Wolfgang Resch; Davide F Robbiani; Israel T Silva; Arito Yamane; Rafael Casellas; Niklas Feldhahn; Michel C Nussenzweig
53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma.
Michela Di Virgilio; Niklas Feldhahn; Alexander D Gitlin; Mila Jankovic; André Nussenzweig; Thiago Y Oliveira; Wolfgang Resch; Davide F Robbiani; Arito Yamane; Wenzhu Zhang; Elsa Callen; Rafael Casellas; Brian T Chait; Michel C Nussenzweig
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Jacqueline H Barlow; Elsa Callén; Rafael Casellas; Hua Tang Chen; Robert B Faryabi; Oscar Fernandez-Capetillo; Gustavo Gutierrez-Cruz; Amy Malhowski; Peter McKinnon; Davide F Robbiani; Louis Staudt; Hong-Wei Sun; Nancy Wong; George Wright; André Nussenzweig
Identification of early replicating fragile sites that contribute to genome instability.

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All Publications

2013: Mila Jankovic; Kyong-Rim Kieffer-Kwon; Isaac Klein; Thiago Y Oliveira; Wolfgang Resch; Davide F Robbiani; Israel T Silva; Arito Yamane; Rafael Casellas; Niklas Feldhahn; Michel C Nussenzweig
53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma.
Molecular cell 2013;49(4):623-31.
2013: Michela Di Virgilio; Niklas Feldhahn; Alexander D Gitlin; Mila Jankovic; André Nussenzweig; Thiago Y Oliveira; Wolfgang Resch; Davide F Robbiani; Arito Yamane; Wenzhu Zhang; Elsa Callen; Rafael Casellas; Brian T Chait; Michel C Nussenzweig
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Science (New York, N.Y.) 2013;339(6120):711-5.
2013: Jacqueline H Barlow; Elsa Callén; Rafael Casellas; Hua Tang Chen; Robert B Faryabi; Oscar Fernandez-Capetillo; Gustavo Gutierrez-Cruz; Amy Malhowski; Peter McKinnon; Davide F Robbiani; Louis Staudt; Hong-Wei Sun; Nancy Wong; George Wright; André Nussenzweig
Identification of early replicating fragile sites that contribute to genome instability.
Cell 2013;152(3):620-32.
2013: Arito Yamane; Anne Bothmer; Eric J Brown; Hirotaka Nakahashi; André Nussenzweig; Michel C Nussenzweig; Thiago Oliveira; Wolfgang Resch; Davide F Robbiani; Philipp C Rommel; Rafael Casellas
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle.
Cell reports 2013;3(1):138-47.
2013: Anne Bothmer; Robert M Brosh; Rafael Casellas; Phang-Lang Chen; Winfried Edelmann; Anna Gazumyan; Thomas Ludwig; Matthias F Muellenbeck; André Nussenzweig; Michel C Nussenzweig; Federica Polato; Colleen R Reczek; Philipp C Rommel; Sonja Schaetzlein; Richard Baer; Davide F Robbiani
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
The Journal of experimental medicine 2013;210(1):115-23.
2012: Zuqin Nie; Wolfgang Resch; Lino Tessarollo; Ruoning Wang; Gang Wei; Arito Yamane; Keji Zhao; Rafael Casellas; Kairong Cui; Douglas R Green; Gangqing Hu; David Levens
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.
Cell 2012;151(1):68-79.
2012: Matthew M Meredith; Rafael Casellas; Pierre Guermonprez; Juliana Idoyaga; Alice O Kamphorst; Kang Liu; Thiago Y Oliveira; Suzannah Rihn; Israel T Silva; Dimitris Skokos; Arito Yamane; Kai-Hui Yao; Michel C Nussenzweig
Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.
The Journal of experimental medicine 2012;209(9):1583-93.
2012: Elizabeth Spehalski; Rafael Casellas; John T Collins; Wendy DuBois; David O Ferguson; Alexander L Kovalchuk; Genqing Liang; Herbert C Morse; Wesley A Dunnick
Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13728-32.
2012: Masaya Baba; Paul Bible; Carme Gallego Gonzalez; Hisashi Hasumi; Yukiko Hasumi; Robert M Hughes; Jonathan Keller; Kyong-Rim Kieffer-Kwon; Mara E Klein; Stefan Kuchen; W Marston Linehan; Hyoungbin F Oh; Wolfgang Resch; Laura S Schmidt; Eileen Southon; Hyung Chan Suh; Hong-Wei Sun; Lino Tessarollo; Rafael Casellas
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development.
Blood 2012;120(6):1254-61.
2012: Alexander L Kovalchuk; Herbert C Morse; Michel C Nussenzweig; Michael Potter; Wolfgang Resch; Makiko Takizawa; Helena Tolarová; Arito Yamane; Wendy DuBois; Gordon L Hager; Ofir Hakim; Isaac Klein; Camilo Ansarah-Sobrinho; Rafael Casellas
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(27):10972-7.
2012: Hayato Takahashi; Lai Wei; Giuseppe Sciumè; Rafael Casellas; Kiyoshi Hirahara; Tomohiko Kanno; Yuka Kanno; Stefan Kuchen; Stefan A Muljo; Shingo Nakayamada; John J O'Shea
TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Nature immunology 2012;13(6):587-95.
2012: Ofir Hakim; Mila Jankovic; Kyong-Rim Kieffer-Kwon; Isaac Klein; Genqing Liang; Ewy Mathe; Hirotaka Nakahashi; André Nussenzweig; Michel C Nussenzweig; Thiago Oliveira; Wolfgang Resch; Davide F Robbiani; Ty C Voss; Arito Yamane; Camilo Ansarah-Sobrinho; Anne Bothmer; Jesse Cobell; Gordon L Hager; Rafael Casellas
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Nature 2012;484(7392):69-74.
2011: Isaac A Klein; Hirotaka Nakahashi; André Nussenzweig; Anne Bothmer; Rafael Casellas; Michela Di Virgilio; Mila Jankovic; Thiago Oliveira; Wolfgang Resch; Davide F Robbiani; Arito Yamane; Michel C Nussenzweig
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.
Cell 2011;147(1):95-106.
2010: Rushad Pavri; Anna Gazumyan; Mila Jankovic; Michela Di Virgilio; Isaac Klein; Camilo Ansarah-Sobrinho; Wolfgang Resch; Arito Yamane; Bernardo Reina San-Martin; Vasco M Barreto; Thomas J Nieland; David E Root; Rafael Casellas; Michel C Nussenzweig
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.
Cell 2010;143(1):122-33.
2010: Jeremy A Daniel; Margarida Almeida Santos; Zhibin Wang; Chongzhi Zang; Kristopher R Schwab; Mila Jankovic; Darius Filsuf; Hua-Tang Chen; Anna Gazumyan; Arito Yamane; Young-Wook Cho; Hong-Wei Sun; Kai Ge; Weiqun Peng; Michel C Nussenzweig; Rafael Casellas; Gregory R Dressler; Keji Zhao; André Nussenzweig
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Science (New York, N.Y.) 2010;329(5994):917-23.
2010: M Takizawa; Joong Su Kim; Lino Tessarollo; N McNeil; T J Waldschmidt; Rafael Casellas; Thomas Ried; Siegfried Janz
Genetic reporter system for oncogenic Igh-Myc translocations in mice.
Oncogene 2010;29(28):4113-20.
2010: Stefan Kuchen; Wolfgang Resch; Arito Yamane; Nan Kuo; Zhiyu Li; Tirtha Chakraborty; Lai Wei; Arian Dominic John laurence; Tomoharu Yasuda; Siying Peng; Jane Hu-Li; Kristina Lu; Wendy Dubois; Yoshiaki Kitamura; Nicolas Charles; Hong-Wei Sun; Stefan Muljo; Pamela L Schwartzberg; William E Paul; John O'Shea; Klaus Rajewsky; Rafael Casellas
Regulation of microRNA expression and abundance during lymphopoiesis.
Immunity 2010;32(6):828-39.
2009: Rafael Casellas; Arito Yamane; Alexander L Kovalchuk; Michael Potter
Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes.
Immunology 2009;126(3):316-28.
2008: Makiko Takizawa; Helena Tolarová; Zhiyu Li; Wendy Dubois; Susan Lim; Elsa Callen; Sonia Franco; Maria Mosaico; Lionel Feigenbaum; Frederick W Alt; André Nussenzweig; Michael Potter; Rafael Casellas
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.
The Journal of experimental medicine 2008;205(9):1949-57.
2008: Grace Teng; Paul Hakimpour; Pablo Landgraf; Amanda Rice; Thomas Tuschl; Rafael Casellas; F Nina Papavasiliou
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase.
Immunity 2008;28(5):621-9.
2007: Michael J Kruhlak; Elizabeth E Crouch; Marika Orlov; Carolina Montaño; Stanislaw A Gorski; André Nussenzweig; Tom Misteli; Robert Phair; Rafael Casellas
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Nature 2007;447(7145):730-4.
2007: Elizabeth E Crouch; Zhiyu Li; Makiko Takizawa; Stefan Fichtner-Feigl; Polyxeni Gourzi; Carolina Montaño; Lionel Feigenbaum; Patrick Wilson; Siegfried Janz; F Nina Papavasiliou; Rafael Casellas
Regulation of AID expression in the immune response.
The Journal of experimental medicine 2007;204(5):1145-56.
2007: Rafael Casellas; Qingzhao Zhang; Nai-Ying Zheng; Melissa D Mathias; Kenneth Smith; Patrick C Wilson
Igkappa allelic inclusion is a consequence of receptor editing.
The Journal of experimental medicine 2007;204(1):153-60.
2006: Yasuko Furumoto; Steve Brooks; Ana Olivera; Yasuomi Takagi; Makoto Miyagishi; Kazunari Taira; Rafael Casellas; Michael A Beaven; Alasdair M Gilfillan; Juan Rivera
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5167-71.
2004: Mila Jankovic; Rafael Casellas; Nikos Yannoutsos; Hedda Wardemann; Michel C Nussenzweig
RAGs and regulation of autoantibodies.
Annual review of immunology 2004;22():485-501.
2002: Rafael Casellas; Mila Jankovic; Gesa Meyer; Anna Gazumyan; Yan Luo; Robert Roeder; Michel C Nussenzweig
OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes.
Cell 2002;110(5):575-85.
2001: Simone Petersen; Rafael Casellas; Bernardo Reina-San-Martin; Hua-Tang Chen; Michael J Difilippantonio; Patrick C Wilson; L Hanitsch; Arkady Celeste; M Muramatsu; Duane R Pilch; Christophe Redon; Thomas Ried; William M Bonner; T Honjo; Michel C Nussenzweig; André Nussenzweig
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Nature 2001;414(6864):660-5.
2001: Rafael Casellas; Tien-An Yang Shih; M Kleinewietfeld; J Rakonjac; D Nemazee; Klaus Rajewsky; Michel C Nussenzweig
Contribution of receptor editing to the antibody repertoire.
Science (New York, N.Y.) 2001;291(5508):1541-4.
2000: Eric Meffre; Rafael Casellas; Michel C Nussenzweig
Antibody regulation of B cell development.
Nature immunology 2000;1(5):379-85.
1999: Wenjie Yu; H Nagaoka; Ziva Misulovin; Eric Meffre; H Suh; Mila Jankovic; Nikos Yannoutsos; Rafael Casellas; Eva Besmer; F Nina Papavasiliou; X Qin; Michel C Nussenzweig
RAG expression in B cells in secondary lymphoid tissues.
Cold Spring Harbor symposia on quantitative biology 1999;64():207-10.
1998: Rafael Casellas; Ali H Brivanlou
Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer.
Developmental biology 1998;198(1):1-12.
1998: Rafael Casellas; André Nussenzweig; Robert Wuerffel; Roberta Pelanda; Amy Reichlin; H Suh; XF Qin; Eva Besmer; Amy L Kenter; Klaus Rajewsky; Michel C Nussenzweig
Ku80 is required for immunoglobulin isotype switching.
The EMBO journal 1998;17(8):2404-11.
1997: F Nina Papavasiliou; Rafael Casellas; H Suh; XF Qin; Eva Besmer; Roberta Pelanda; D Nemazee; Klaus Rajewsky; Michel C Nussenzweig
V(D)J recombination in mature B cells: a mechanism for altering antibody responses.
Science (New York, N.Y.) 1997;278(5336):298-301.