FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

dorothy Keefe

Research Profile

Disorders

Chemicals & Drugs

Living Beings

Rats

Anatomy

Procedures

Concepts & Ideas

Practice Guidelines as Topic

Occupations

Evidence-Based Medicine

Co-author Network

Publications

TOP 3
Noor Al-Dasooqi; Rachel J Gibson; Joanne M Bowen; Richard Logan; Andrea M Stringer; dorothy Keefe
Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat.
dorothy Keefe; Andrea Stringer
The potential successes and challenges of targeted anticancer therapies.
Joanne M Bowen; Anna Tsykin; Andrea M Stringer; Richard Logan; Rachel J Gibson; dorothy Keefe
Kinetics and regional specificity of irinotecan-induced gene expression in the gastrointestinal tract.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of dorothy Keefe (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2010: Noor Al-Dasooqi; Rachel J Gibson; Joanne M Bowen; Richard Logan; Andrea M Stringer; dorothy Keefe
Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat.
Experimental biology and medicine (Maywood, N.J.) 2010;235(10):1244-56.
2010: dorothy Keefe; Andrea Stringer
The potential successes and challenges of targeted anticancer therapies.
Current opinion in supportive and palliative care 2010;4(1):16-8.
2010: Joanne M Bowen; Anna Tsykin; Andrea M Stringer; Richard Logan; Rachel J Gibson; dorothy Keefe
Kinetics and regional specificity of irinotecan-induced gene expression in the gastrointestinal tract.
Toxicology 2010;269(1):1-12.
2010: Zhi Yi Ong; Rachel J Gibson; Joanne M Bowen; Andrea M Stringer; Jocelyn M Darby; Richard M Logan; Ann Sj Yeoh; dorothy Keefe
Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis.
Radiation oncology (London, England) 2010;5():22.
2009: Andrea M Stringer; Rachel J Gibson; Joanne M Bowen; Richard Logan; Kimberly Ashton; Ann S-J Yeoh; Noor Al-Dasooqi; dorothy Keefe
Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile.
International journal of experimental pathology 2009;90(5):489-99.
2009: Noor Al-Dasooqi; Rachel Gibson; Joanne Bowen; dorothy Keefe
HER2 targeted therapies for cancer and the gastrointestinal tract.
Current drug targets 2009;10(6):537-42.
2009: Noor Al-Dasooqi; Rachel J Gibson; Joanne M Bowen; dorothy Keefe
Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis?
Cancer chemotherapy and pharmacology 2009;64(1):1-9.
2009: Andrea M Stringer; Rachel J Gibson; Richard Logan; Joanne M Bowen; Ann S-J Yeoh; Jessica Laurence; dorothy Keefe
Irinotecan-induced mucositis is associated with changes in intestinal mucins.
Cancer chemotherapy and pharmacology 2009;64(1):123-32.
2009: Andrea M Stringer; Rachel J Gibson; Richard Logan; Joanne M Bowen; Ann S-J Yeoh; Juliette Hamilton; dorothy Keefe
Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis.
Experimental biology and medicine (Maywood, N.J.) 2009;234(4):430-41.
2009: Noor Al-Dasooqi; Joanne M Bowen; Rachel J Gibson; Thomas Sullivan; Jude Lees; dorothy Keefe
Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients.
Investigational new drugs 2009;27(2):173-8.
2009: Giuseppe Aprile; Marco Ramoni; dorothy Keefe; Stephen Sonis
Links between regimen-related toxicities in patients being treated for colorectal cancer.
Current opinion in supportive and palliative care 2009;3(1):50-4.
2009: Andrea M Stringer; Rachel J Gibson; Joanne M Bowen; dorothy Keefe
Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change.
Current drug metabolism 2009;10(1):79-83.
2009: Richard Logan; Andrea M Stringer; Joanne M Bowen; Rachel J Gibson; Stephen T Sonis; dorothy Keefe
Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?
Cancer chemotherapy and pharmacology 2009;63(2):239-51.
2008: Andrea M Stringer; Rachel J Gibson; Richard Logan; Joanne M Bowen; Ann S-J Yeoh; dorothy Keefe
Faecal microflora and beta-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats.
Cancer biology & therapy 2008;7(12):1919-25.
2008: Linda S Elting; dorothy Keefe; Stephen T Sonis; Adam S Garden; F K L Spijkervet; Andrei Barasch; Roy B Tishler; Thomas P Canty; Mahesh K Kudrimoti; Montserrat Vera-Llonch
Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life.
Cancer 2008;113(10):2704-13.
2008: Pasquale Niscola; Laura Scaramucci; Claudio Romani; Luca Cupelli; Andrea Tendas; Teresa Dentamaro; M Ales; M Giovannini; Daniela Piccioni; A Siniscalchi; B Tolu; Marco Giovannini; Alessio Pio Perrotti; dorothy Keefe; Paolo De Fabritiis
Mucositis in the treatment of haematological malignancies.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19 Suppl 7():vii141-5.
2008: dorothy Keefe; Stephen T Sonis; Joanne M Bowen
Emerging drugs for chemotherapy-induced mucositis.
Expert opinion on emerging drugs 2008;13(3):511-22.
2008: Rachel J Gibson; Joanne M Bowen; dorothy Keefe
Technological advances in mucositis research: new insights and new issues.
Cancer treatment reviews 2008;34(5):476-82.
2008: Richard Logan; Andrea M Stringer; Joanne M Bowen; Rachel J Gibson; Stephen T Sonis; dorothy Keefe
Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs.
Cancer biology & therapy 2008;7(7):1139-45.
2008: Richard Logan; Rachel J Gibson; Joanne M Bowen; Andrea M Stringer; Stephen T Sonis; dorothy Keefe
Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis.
Cancer chemotherapy and pharmacology 2008;62(1):33-41.
2008: dorothy Keefe; Lowell Anthony
Tyrosine kinase inhibitors and gut toxicity: a new era in supportive care.
Current opinion in supportive and palliative care 2008;2(1):19-21.
2008: Giuseppe Aprile; Marco Ramoni; dorothy Keefe; Stephen T Sonis
Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy.
Cancer 2008;112(2):284-92.
2008: Joanne M Bowen; dorothy Keefe
New pathways for alimentary mucositis.
Journal of oncology 2008;2008():907892.
2007: Joanne M Bowen; Rachel J Gibson; Anna Tsykin; Andrea M Stringer; Richard Logan; dorothy Keefe
Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy.
International journal of cancer. Journal international du cancer 2007;121(8):1847-56.
2007: Joanne M Bowen; Andrea M Stringer; Rachel J Gibson; Ann S-J Yeoh; Sarah Hannam; dorothy Keefe
VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight loss.
Cancer biology & therapy 2007;6(9):1449-54.
2007: dorothy Keefe; Georgina Rassias; Lisa O'Neil; Rachel J Gibson
Severe mucositis: how can nutrition help?
Current opinion in clinical nutrition and metabolic care 2007;10(5):627-31.
2007: Rohit Joshi; Ian N Olver; dorothy Keefe; Toni Marafioti; Keith Smith
A phase I study to assess the safety and activity of topical lovastatin (FP252S) for the prevention of chemotherapy-induced alopecia.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2007;15(9):1109-12.
2007: Ann S-J Yeoh; Rachel J Gibson; Eric E K Yeoh; Joanne M Bowen; Andrea M Stringer; Kar A Giam; dorothy Keefe
A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2.
Molecular cancer therapeutics 2007;6(8):2319-27.
2007: Richard Logan; Andrea M Stringer; Joanne M Bowen; Ann S-J Yeoh; Rachel J Gibson; Stephen T Sonis; dorothy Keefe
The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs.
Cancer treatment reviews 2007;33(5):448-60.
2007: dorothy Keefe
Intestinal mucositis: mechanisms and management.
Current opinion in oncology 2007;19(4):323-7.
2007: Andrea M Stringer; Rachel J Gibson; Joanne M Bowen; Richard Logan; Ann S-J Yeoh; dorothy Keefe
Chemotherapy-induced mucositis: the role of gastrointestinal microflora and mucins in the luminal environment.
The journal of supportive oncology 2007;5(6):259-67.
2007: dorothy Keefe; Rachel J Gibson
Mucosal injury from targeted anti-cancer therapy.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2007;15(5):483-90.
2007: dorothy Keefe
Supportive care silos: time to forge cross-links, using mucositis as an example.
Current opinion in supportive and palliative care 2007;1(1):40-2.
2007: Rachel J Gibson; Andrea M Stringer; Joanne M Bowen; Richard Logan; Ann S-J Yeoh; Jaimi Burns; Enrique Alvarez; dorothy Keefe
Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA rats.
Cancer biology & therapy 2007;6(4):541-7.
2007: Richard Logan; Rachel J Gibson; Stephen T Sonis; dorothy Keefe
Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy.
Oral oncology 2007;43(4):395-401.
2007: dorothy Keefe; Mark M Schubert; Linda S Elting; Stephen T Sonis; Joel B Epstein; Judith Raber-Durlacher; Cesar A Migliorati; Deborah B McGuire; Ronald D Hutchins; Douglas E Peterson
Updated clinical practice guidelines for the prevention and treatment of mucositis.
Cancer 2007;109(5):820-31.
2007: Joanne M Bowen; Rachel J Gibson; Andrea M Stringer; Thong W Chan; Avanita S Prabowo; Adrian G Cummins; dorothy Keefe
Role of p53 in irinotecan-induced intestinal cell death and mucosal damage.
Anti-cancer drugs 2007;18(2):197-210.
2007: Joanne M Bowen; Rachel J Gibson; Adrian G Cummins; Anna Tyskin; dorothy Keefe
Irinotecan changes gene expression in the small intestine of the rat with breast cancer.
Cancer chemotherapy and pharmacology 2007;59(3):337-48.
2007: Rachel J Gibson; Joanne M Bowen; Enrique Alvarez; John W Finnie; dorothy Keefe
Establishment of a single-dose irinotecan model of gastrointestinal mucositis.
Chemotherapy 2007;53(5):360-9.
2007: Andrea M Stringer; Rachel J Gibson; Richard Logan; Joanne M Bowen; Ann S-J Yeoh; Jaimi Burns; dorothy Keefe
Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA rat.
Experimental biology and medicine (Maywood, N.J.) 2007;232(1):96-106.
2006: Ann S-J Yeoh; Rachel Gibson; Eric Yeoh; Joanne Bowen; Andrea M Stringer; Kar Giam; Richard Logan; dorothy Keefe
Radiation therapy-induced mucositis: relationships between fractionated radiation, NF-kappaB, COX-1, and COX-2.
Cancer treatment reviews 2006;32(8):645-51.
2006: Ken Pittman; Ian N Olver; Bogda Koczwara; D Kotasek; W K Patterson; dorothy Keefe; Christos Karapetis; FX Parnis; S Moldovan; S J Yeend; Timothy J Price
Gemcitabine and carboplatin in carcinoma of unknown primary site: a phase 2 Adelaide Cancer Trials and Education Collaborative study.
British journal of cancer 2006;95(10):1309-13.
2006: dorothy Keefe; Rachel J Gibson
The combination of oral and small intestinal mucositis, pediatrics and biomarkers: a particularly tricky problem!
Cancer biology & therapy 2006;5(10):1282-4.
2006: dorothy Keefe; Rachel J Gibson
Sucrose breath testing and intestinal mucositis.
Cancer biology & therapy 2006;5(9):1196-8.
2006: Rachel J Gibson; dorothy Keefe
Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(9):890-900.
2006: Joanne M Bowen; Rachel J Gibson; Adrian G Cummins; dorothy Keefe
Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(7):713-31.
2006: dorothy Keefe; Jude Lees; Noemi Horvath
Palifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(6):580-2.
2006: Inger von Bültzingslöwen; Michael T Brennan; F K L Spijkervet; Richard Logan; Andrea M Stringer; Judith Raber-Durlacher; dorothy Keefe
Growth factors and cytokines in the prevention and treatment of oral and gastrointestinal mucositis.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(6):519-27.
2006: Douglas E Peterson; dorothy Keefe; Ronald D Hutchins; Mark M Schubert
Alimentary tract mucositis in cancer patients: impact of terminology and assessment on research and clinical practice.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(6):499-504.
2006: Michael T Brennan; Inger von Bültzingslöwen; Mark M Schubert; dorothy Keefe
Alimentary mucositis: putting the guidelines into practice.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(6):573-9.
2006: dorothy Keefe; Douglas E Peterson; Mark M Schubert
Developing evidence-based guidelines for management of alimentary mucositis: process and pitfalls.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(6):492-8.
2006: René-Jean Bensadoun; Mark M Schubert; Rajesh V Lalla; dorothy Keefe
Amifostine in the management of radiation-induced and chemo-induced mucositis.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(6):566-72.
2006: dorothy Keefe
Mucositis guidelines: what have they achieved, and where to from here?
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(6):489-91.
2006: Rajesh V Lalla; Mark M Schubert; René-Jean Bensadoun; dorothy Keefe
Anti-inflammatory agents in the management of alimentary mucositis.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006;14(6):558-65.
2006: dorothy Keefe
Mucositis management in patients with cancer.
Supportive cancer therapy 2006;3(3):154-7.
2005: Ann S-J Yeoh; Joanne M Bowen; Rachel J Gibson; dorothy Keefe
Nuclear factor kappaB (NFkappaB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes.
International journal of radiation oncology, biology, physics 2005;63(5):1295-303.
2005: Rachel J Gibson; Joanne M Bowen; dorothy Keefe
Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats.
International journal of cancer. Journal international du cancer 2005;116(3):464-70.
2005: I Olver; dorothy Keefe; M Myers
Phase II study of prolonged ambulatory infusion carboplatin and oral etoposide for patients progressing through hormonal therapy for prostate cancer.
Internal medicine journal 2005;35(7):405-8.
2005: Ian N Olver; dorothy Keefe; Melinda Myers; Diana Caruso
A phase I study of prolonged ambulatory infusion of Ifosfamide with oral mesna.
Chemotherapy 2005;51(2-3):142-6.
2005: Rachel J Gibson; Joanne M Bowen; Adrian G Cummins; dorothy Keefe
Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the rat.
Clinical and experimental medicine 2005;4(4):188-95.
2005: Joanne M Bowen; Rachel J Gibson; dorothy Keefe; Adrian G Cummins
Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans.
Pathology 2005;37(1):56-62.
2004: Edward B Rubenstein; Douglas E Peterson; Mark Schubert; dorothy Keefe; Deborah McGuire; Joel B Epstein; Linda S Elting; Philip C Fox; Catherine Cooksley; Stephen T Sonis
Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis.
Cancer 2004;100(9 Suppl):2026-46.
2004: Stephen T Sonis; Linda S Elting; dorothy Keefe; Douglas E Peterson; Mark Schubert; Martin Hauer-Jensen; B Nebiyou Bekele; Judith Raber-Durlacher; J Peter Donnelly; Edward B Rubenstein
Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients.
Cancer 2004;100(9 Suppl):1995-2025.
2004: Douglas E Peterson; Susan L Beck; dorothy Keefe
Novel therapies.
Seminars in oncology nursing 2004;20(1):53-8.
2004: dorothy Keefe; Rachel J Gibson; Martin Hauer-Jensen
Gastrointestinal mucositis.
Seminars in oncology nursing 2004;20(1):38-47.
2004: dorothy Keefe
Gastrointestinal mucositis: a new biological model.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2004;12(1):6-9.
2003: Rachel J Gibson; Joanne M Bowen; Mark R B Inglis; Adrian G Cummins; dorothy Keefe
Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer.
Journal of gastroenterology and hepatology 2003;18(9):1095-100.
2002: Rachel J Gibson; dorothy Keefe; Fiona M Thompson; Julie M Clarke; Gary J Goland; Adrian G Cummins
Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats.
Digestive diseases and sciences 2002;47(12):2751-7.
2002: Ian N Olver; Tim Hercus; Angel Lopez; Matthew Vadas; Andrew A Somogyi; Ian Doyle; David J R Foster; dorothy Keefe; Anne Taylor; Michael Brown; L Bik To; Julie Cole; Trevor Rawling; Bronwyn Cambareri; Melinda Myers; Nancy Olszewski; Stan Bastiras; Carol Senn; Allan Hey; Meera Verma; Peter Wigley
A phase I study of the GM-CSF antagonist E21R.
Cancer chemotherapy and pharmacology 2002;50(3):171-8.
2002: Rachel J Gibson; dorothy Keefe; Julie M Clarke; Geoff O Regester; Fiona M Thompson; Gary J Goland; Ben G Edwards; Adrian G Cummins
The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer.
Cancer chemotherapy and pharmacology 2002;50(1):53-8.
2000: dorothy Keefe; J Brealey; Gary J Goland; Adrian G Cummins
Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans.
Gut 2000;47(5):632-7.
2000: FX Parnis; Ian N Olver; D Kotasek; J Norman; A Taylor; J Russell; K Patterson; dorothy Keefe; T Marafioti
Phase II study of epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF) for carcinoma of unknown primary site.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(7):883-4.
1999: C J Turtle; dorothy Keefe; D Bell; H Wheeler; D D Ma
Severe adverse reaction to high dose epirubicin and cyclophosphamide for poor prognosis breast cancer.
Australian and New Zealand journal of medicine 1999;29(2):275-7.
1999: Russell L Basser; L Bik To; J P Collins; C Glenn Begley; dorothy Keefe; Jonathan Cebon; John Bashford; Simon Durrant; Jeff Szer; D Kotasek; CA Juttner; I Russell; Darryl W Maher; Ian N Olver; William Patrick Sheridan; Richard M Fox; Michael D Green
Multicycle high-dose chemotherapy and filgrastim-mobilized peripheral-blood progenitor cells in women with high-risk stage II or III breast cancer: five-year follow-up.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(1):82-92.
1997: dorothy Keefe; Adrian G Cummins; B M Dale; D Kotasek; T A Robb; R E Sage
Effect of high-dose chemotherapy on intestinal permeability in humans.
Clinical science (London, England : 1979) 1997;92(4):385-9.
1994: W K Patterson; R E Sage; dorothy Keefe
Haemorrhagic gastritis in two patients treated with all-trans-retinoic acid in acute promyelocytic leukaemia.
Australian and New Zealand journal of medicine 1994;24(3):314-5.