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Robert Casero

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Lihua Jin; Ben Ho Park; Wei Wang; Patrick M Woster; Yu Wu; Christin L Hanigan; Robert A Casero
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.
Koichi Takao; Robert A Casero; Kazuei Igarashi; Keijiro Samejima; Akira Shirahata; Yoshiaki Sugita
Pentamines as substrate for human spermine oxidase.
Shannon L Nowotarski; Patrick M Woster; Robert A Casero
Polyamines and cancer: implications for chemotherapy and chemoprevention.

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2013: Lihua Jin; Ben Ho Park; Wei Wang; Patrick M Woster; Yu Wu; Christin L Hanigan; Robert A Casero
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.
The Biochemical journal 2013;449(2):459-68.
2013: Koichi Takao; Robert A Casero; Kazuei Igarashi; Keijiro Samejima; Akira Shirahata; Yoshiaki Sugita
Pentamines as substrate for human spermine oxidase.
Biological & pharmaceutical bulletin 2013;36(3):407-11.
2013: Shannon L Nowotarski; Patrick M Woster; Robert A Casero
Polyamines and cancer: implications for chemotherapy and chemoprevention.
Expert reviews in molecular medicine 2013;15():e3.
2012: Qingsong Zhu; Lihua Jin; Robert A Casero; Nancy E Davidson; Yi Huang
Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.
Breast cancer research and treatment 2012;136(1):57-66.
2012: Stuart T Hazeldine; Shannon Nowotarski; Boobalan Pachaiyappan; Nora Steinbergs; Robert A Casero; Allison S Hanson; Patrick M Woster
Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.
Journal of medicinal chemistry 2012;55(17):7378-91.
2012: Kamyar Zahedi; Nora Steinbergs; Jiang Wang; Jie Xu; Hassane Amlal; Sharon L Barone; Robert A Casero; Alex B Lentsch; Rebecca Schuster; Manoocher Soleimani
Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(5):G546-60.
2012: Tino Schenk; Jean C Y Wang; Patrick M Woster; Alan Burnett; Robert A Casero; Weihsu Claire Chen; John E Dick; Martin Dugas; Stefanie Göllner; Katja Hebestreit; Louise Howell; Liqing Jin; Hans-Ulrich Klein; Laurence Marton; Ken Mills; Mark D Minden; Carsten Müller-Tidow; Kevin Petrie; Andreea C Popescu; Arthur Zelent
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
Nature medicine 2012;18(4):605-11.
2012: Oscar Perez-Leal; Carlos A Barrero; Robert A Casero; Allen B Clarkson; Salim Merali
Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase.
Molecular and cellular biology 2012;32(8):1453-67.
2012: Yu Wu; Laurence J Marton; Tracy Murray-Stewart; Nora Steinbergs; Robert A Casero
Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.
The Biochemical journal 2012;442(3):693-701.
2012: Alison V Fraser; Andrew C Goodwin; Amy Hacker-Prietz; Elizabeth Sugar; Patrick M Woster; Robert A Casero
Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.
Amino acids 2012;42(2-3):529-38.
2012: Richard Poulin; Robert A Casero; Denis Soulet
Recent advances in the molecular biology of metazoan polyamine transport.
Amino acids 2012;42(2-3):711-23.
2012: Qingsong Zhu; Nancy E Davidson; Yi Huang; Laurence J Marton; Patrick M Woster; Robert A Casero
Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.
Amino acids 2012;42(2-3):887-98.
2012: Lori A Coburn; Xue Gong; M Blanca Piazuelo; Michael J Rosen; Brooks P Scull; Kshipra Singh; M Kay Washington; Christopher Williams; Margaret M Allaman; Mohammad Asim; Daniel P Barry; Robert A Casero; Rupesh Chaturvedi; Zhongming Zhao; Keith T Wilson
L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis.
PloS one 2012;7(3):e33546.
2011: Heather M O'Hagan; Cynthia L Sears; Subhojit Sen; Leander Van Neste; Wei Wang; Yang W Zhang; Yi Cai; Robert A Casero; Eriko G Clements; Christina Destefano Shields; Hariharan Easwaran; Stella S Lee; Stephen B Baylin
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
Cancer cell 2011;20(5):606-19.
2011: Pravin Bhansali; Robert A Casero; Christin L Hanigan; L M Viranga Tillekeratne
Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.
Journal of medicinal chemistry 2011;54(21):7453-63.
2011: Rupesh Chaturvedi; Pelayo Correa; Thibaut de Sablet; Alberto G Delgado; Alain P Gobert; Svea Hoge; Dawn A Israel; Richard M Peek; M Blanca Piazuelo; D Brent Polk; Judith Romero-Gallo; Mohammad Asim; Daniel P Barry; Robert A Casero; Lydia E Wroblewski; Fang Yan; Keith T Wilson
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.
Gastroenterology 2011;141(5):1696-708.e1-2.
2011: Andrew C Goodwin; Amy Hacker-Prietz; David L Huso; Tracy Murray-Stewart; Shervin Rabizadeh; Cynthia L Sears; Christina E Destefano Shields; Patrick M Woster; Shaoguang Wu; XinQun Wu; Robert A Casero
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):15354-9.
2011: Steven A Belinsky; Marcie J Grimes; Maria A Picchi; Hugh D Mitchell; Christine A Stidley; Stephanie Holmgren; Meghan M Channell; Yanbin Liu; Robert A Casero; Stephen B Baylin; Mathew D Reed; Carmen S Tellez; Thomas H March
Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model.
Cancer research 2011;71(2):454-62.
2011: Daniel P Barry; Mohammad Asim; David A Leiman; Thibaut de Sablet; Kshipra Singh; Robert A Casero; Rupesh Chaturvedi; Keith T Wilson
Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.
PloS one 2011;6(2):e17510.
2011: Andrew C Goodwin; Tracy Murray-Stewart; Robert A Casero
A simple assay for mammalian spermine oxidase: a polyamine catabolic enzyme implicated in drug response and disease.
Methods in molecular biology (Clifton, N.J.) 2011;720():173-81.
2011: Anthony E Pegg; Robert A Casero
Current status of the polyamine research field.
Methods in molecular biology (Clifton, N.J.) 2011;720():3-35.
2010: Rupesh Chaturvedi; Mohammad Asim; Svea Hoge; Nuruddeen D Lewis; Kshipra Singh; Daniel P Barry; Thibaut de Sablet; M Blanca Piazuelo; Aditya R Sarvaria; Yulan Cheng; Ellen I Closs; Robert A Casero; Alain P Gobert; Keith T Wilson
Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.
Gastroenterology 2010;139(5):1686-98, 1698.e1-6.
2010: Shih-Kuang S Hong; Rupesh Chaturvedi; M Blanca Piazuelo; Lori A Coburn; Christopher Williams; Alberto G Delgado; Robert A Casero; David A Schwartz; Keith T Wilson
Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity.
Inflammatory bowel diseases 2010;16(9):1557-66.
2010: Shiv K Sharma; Yu Wu; Nora Steinbergs; Michael L Crowley; Allison S Hanson; Robert A Casero; Patrick M Woster
(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators.
Journal of medicinal chemistry 2010;53(14):5197-212.
2010: Megan A Healey; Staci L Deaton; Jonathan K Alder; Véronique Winnepenninckx; Robert A Casero; James G Herman
Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma.
Epigenetics : official journal of the DNA Methylation Society 2010;5(5):410-21.
2010: Seung Bum Lee; Jong Hwan Park; Patrick M Woster; Robert A Casero; Myung Hee Park
Suppression of exogenous gene expression by spermidine/spermine N1-acetyltransferase 1 (SSAT1) cotransfection.
The Journal of biological chemistry 2010;285(20):15548-56.
2010: Allison Pledgie-Tracy; Madhavi Billam; Amy Hacker; Michele D Sobolewski; Patrick M Woster; Zhe Zhang; Robert A Casero; Nancy E Davidson
The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.
Cancer chemotherapy and pharmacology 2010;65(6):1067-81.
2010: Kamyar Zahedi; Francis Huttinger; Ryan Morrison; Tracy Murray-Stewart; Robert A Casero; Kenneth I Strauss
Polyamine catabolism is enhanced after traumatic brain injury.
Journal of neurotrauma 2010;27(3):515-25.
2010: Merja R Häkkinen; Mervi T Hyvönen; Seppo Auriola; Robert A Casero; Jouko Vepsäläinen; Alex R Khomutov; Leena Alhonen; Tuomo A Keinänen
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases.
Amino acids 2010;38(2):369-81.
2010: Manuela Cervelli; Gabriella Bellavia; Emiliano Fratini; Roberto Amendola; Fabio Polticelli; Marco Barba; Rodolfo Federico; Fabrizio Signore; Giacomo Gucciardo; Rosalba Grillo; Patrick M Woster; Robert A Casero; Paolo Mariottini
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.
BMC cancer 2010;10():555.
2009: Yi Huang; Tracy Murray-Stewart; Yu Wu; Stephen B Baylin; Laurence J Marton; Brandy Perkins; Richard J Jones; Patrick M Woster; Robert A Casero
Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(23):7217-28.
2009: Robert A Casero; Patrick M Woster
Recent advances in the development of polyamine analogues as antitumor agents.
Journal of medicinal chemistry 2009;52(15):4551-73.
2009: Robert A Casero; Anthony E Pegg
Polyamine catabolism and disease.
The Biochemical journal 2009;421(3):323-38.
2009: Yi Huang; Laurence J Marton; Patrick M Woster; Robert A Casero
Polyamine analogues targeting epigenetic gene regulation.
Essays in biochemistry 2009;46():95-110.
2009: M D Thulani Senanayake; Hemali Amunugama; Tracey D Boncher; Robert A Casero; Patrick M Woster
Design of polyamine-based therapeutic agents: new targets and new directions.
Essays in biochemistry 2009;46():77-94.
2008: Amy Hacker; Laurence J Marton; Michelle Sobolewski; Robert A Casero
In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells.
Cancer chemotherapy and pharmacology 2008;63(1):45-53.
2008: Jennifer Carew; Steffan Nawrocki; Venudhar Reddy; Dorothy Bush; Jerold E Rehg; Andrew Goodwin; Janet A Houghton; Robert A Casero; Laurence J Marton; John L Cleveland
The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib.
Cancer research 2008;68(12):4783-90.
2008: Tracy Murray-Stewart; Yanlin Wang; Andrew Goodwin; Amy Hacker; Alan K Meeker; Robert A Casero
Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.
The FEBS journal 2008;275(11):2795-806.
2008: Andrew C Goodwin; Sana Jadallah; Antoun Toubaji; Kristen Lecksell; Jessica L Hicks; Jeanne Kowalski; G Steven Bova; Angelo M DeMarzo; GEORGES NETTO; Robert A Casero
Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues.
The Prostate 2008;68(7):766-72.
2008: Sheeba Varghese; Thulani Senanayake; Tracy Murray-Stewart; Kim Doering; Alison Fraser; Robert A Casero; Patrick M Woster
Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.
Journal of medicinal chemistry 2008;51(8):2447-56.
2007: Rongcai Jiang; Woonyoung Choi; Asad Khan; Kenneth Hess; Eugene W Gerner; Robert A Casero; W K Alfred Yung; Stanley R Hamilton; Wei Zhang
Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma.
International journal of oncology 2007;31(2):431-40.
2007: J E Rider; Amy Hacker; C A Mackintosh; A E Pegg; Patrick M Woster; Robert A Casero
Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide.
Amino acids 2007;33(2):231-40.
2007: Yi Huang; Eriko Greene; Tracy Murray-Stewart; Andrew C Goodwin; Stephen B Baylin; Patrick M Woster; Robert A Casero
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8023-8.
2007: Robert A Casero; Laurence J Marton
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.
Nature reviews. Drug discovery 2007;6(5):373-90.
2007: T Boncher; X Bi; S Varghese; Robert A Casero; Patrick M Woster
Polyamine-based analogues as biochemical probes and potential therapeutics.
Biochemical Society transactions 2007;35(Pt 2):356-63.
2007: Naveen Babbar; Tracy Murray-Stewart; Robert A Casero
Inflammation and polyamine catabolism: the good, the bad and the ugly.
Biochemical Society transactions 2007;35(Pt 2):300-4.
2007: Wendy L Allen; Estelle G McLean; John Boyer; Andrea McCulla; Peter M Wilson; Vicky Coyle; Daniel B Longley; Robert A Casero; Patrick G Johnston
The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells.
Molecular cancer therapeutics 2007;6(1):128-37.
2006: Naveen Babbar; Robert A Casero
Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis.
Cancer research 2006;66(23):11125-30.
2006: Lan Liu; Xin Guo; Rao Jaladanki; Tongtong Zou; Bernard S Marasa; Jie Chen; Jose Greenspon; Robert A Casero; Jian-Ying Wang
Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region.
The Biochemical journal 2006;398(2):257-67.
2006: Naveen Babbar; Amy Hacker; Yi Huang; Robert A Casero
Tumor necrosis factor alpha induces spermidine/spermine N1-acetyltransferase through nuclear factor kappaB in non-small cell lung cancer cells.
The Journal of biological chemistry 2006;281(34):24182-92.
2006: Yi Huang; Judith C Keen; Allison Pledgie; Laurence J Marton; Tao Zhu; Saraswati Sukumar; Ben Ho Park; Brian G Blair; Keith Brenner; Robert A Casero; Nancy E Davidson
Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells.
The Journal of biological chemistry 2006;281(28):19055-63.
2006: Naveen Babbar; Eugene W Gerner; Robert A Casero
Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells.
The Biochemical journal 2006;394(Pt 1):317-24.
2006: Yanlin Wang; Robert A Casero
Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?
Journal of biochemistry 2006;139(1):17-25.
2006: Pedro Adolfo Sequeira; Fuad G Gwadry; Jarlath ffrench-Mullen; Lilian Canetti; Yves Gingras; Robert A Casero; Guy Rouleau; Chawki Benkelfat; Gustavo Turecki
Implication of SSAT by gene expression and genetic variation in suicide and major depression.
Archives of general psychiatry 2006;63(1):35-48.
2005: Allison Pledgie; Yi Huang; Amy Hacker; Zhe Zhang; Patrick M Woster; Nancy E Davidson; Robert A Casero
Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
The Journal of biological chemistry 2005;280(48):39843-51.
2005: Sheeba Varghese; Deepak Gupta; Tiffany Baran; Anchalee Jiemjit; Steven D Gore; Robert A Casero; Patrick M Woster
Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors.
Journal of medicinal chemistry 2005;48(20):6350-65.
2005: Sharon Barone; Tomohisa Okaya; Steven M Rudich; Snezana Petrovic; Kathy Tenrani; Zhaohui Wang; Kamyar Zahedi; Robert A Casero; Alex B Lentsch; Manoocher Soleimani
Distinct and sequential upregulation of genes regulating cell growth and cell cycle progression during hepatic ischemia-reperfusion injury.
American journal of physiology. Cell physiology 2005;289(4):C826-35.
2005: Yi Huang; Allison Pledgie; Ethel Rubin; Laurence J Marton; Patrick M Woster; Saraswati Sukumar; Robert A Casero; Nancy E Davidson
Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells.
Cancer biology & therapy 2005;4(9):1006-13.
2005: Yanlin Wang; Amy Hacker; Tracy Murray-Stewart; Benjamin Frydman; Aldonia Valasinas; Alison V Fraser; Patrick M Woster; Robert A Casero
Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity.
Cancer chemotherapy and pharmacology 2005;56(1):83-90.
2005: Yulan Cheng; Rupesh Chaturvedi; Mohammad Asim; Françoise I Bussière; Adina Scholz; Hangxiu Xu; Robert A Casero; Keith T Wilson
Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc.
The Journal of biological chemistry 2005;280(23):22492-6.
2005: Alex R Khomutov; Nikolay Grigorenko; Alexander Demin; Jouko Vepsalainen; Robert A Casero; Patrick M Woster
[A charge-deficient analogue of spermine with chelating properties].
Bioorganicheskaia khimiia 2005;31(3):303-11.
2005: Yanlin Wang; Amy Hacker; Tracy Murray-Stewart; Jennifer G Fleischer; Patrick M Woster; Robert A Casero
Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein.
The Biochemical journal 2005;386(Pt 3):543-7.
2005: Yi Huang; Allison Pledgie; Robert A Casero; Nancy E Davidson
Molecular mechanisms of polyamine analogs in cancer cells.
Anti-cancer drugs 2005;16(3):229-41.
2005: Françoise I Bussière; Rupesh Chaturvedi; Yulan Cheng; Alain Gobert; Mohammad Asim; Darren R Blumberg; Hangxiu Xu; Preston Y Kim; Amy Hacker; Robert A Casero; Keith T Wilson
Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation.
The Journal of biological chemistry 2005;280(4):2409-12.
2005: Robert A Casero; Benjamin Frydman; Tracy Murray-Stewart; Patrick M Woster
Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues.
Proceedings of the Western Pharmacology Society 2005;48():24-30.
2004: Yujiang Shi; Fei Lan; Caitlin Matson; Peter Mulligan; Johnathan R Whetstine; Philip A Cole; Robert A Casero; Yang Shi
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Cell 2004;119(7):941-53.
2004: Hangxiu Xu; Rupesh Chaturvedi; Yulan Cheng; Francoise I Bussiere; Mohammad Asim; Micheal D Yao; Darryn Potosky; Meltzer Stephen J.; Juong G Rhee; Sung S Kim; Steven F Moss; Amy Hacker; Yanlin Wang; Robert A Casero; Keith T Wilson
Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis.
Cancer research 2004;64(23):8521-5.
2004: Rupesh Chaturvedi; Yulan Cheng; Mohammad Asim; Françoise I Bussière; Hangxiu Xu; Alain Gobert; Amy Hacker; Robert A Casero; Keith T Wilson
Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization.
The Journal of biological chemistry 2004;279(38):40161-73.
2004: Alain Gobert; Yulan Cheng; Mahmood Akhtar; Benjamin D Mersey; Darren R Blumberg; Raymond K Cross Jr; Rupesh Chaturvedi; Cinthia Drachenberg; Jean-Luc Boucher; Amy Hacker; Robert A Casero; Keith T Wilson
Protective role of arginase in a mouse model of colitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2109-17.
2004: Edward Gabrielson; Ellen Tully; Amy Hacker; Anthony E Pegg; Nancy E Davidson; Robert A Casero
Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine.
Cancer chemotherapy and pharmacology 2004;54(2):122-6.
2004: Zhaohui Wang; Kamyar Zahedi; Sharon Barone; Kathy Tehrani; Hamid Rabb; Karl S Matlin; Robert A Casero; Manoocher Soleimani
Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN 2004;15(7):1844-52.
2004: Yi Huang; Judith C Keen; Erin R Hager; Renee Smith; Amy Hacker; Benjamin Frydman; Aldonia Valasinas; Venudhar Reddy; Laurence J Marton; Robert A Casero; Nancy E Davidson
Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells.
Molecular cancer research : MCR 2004;2(2):81-8.
2004: Francis M Giardiello; Robert A Casero; Stanley R Hamilton; Linda M Hylind; Jill D Trimbath; Deborah E Geiman; Katharine R Judge; Walter Hubbard; G Johan A Offerhaus; Yang Vincent
Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis.
Gastroenterology 2004;126(2):425-31.
2004: Natalia A Ignatenko; Naveen Babbar; Dipti Mehta; Robert A Casero; Eugene W Gerner
Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells.
Molecular carcinogenesis 2004;39(2):91-102.
2003: Antonio C Wolff; Deborah K Armstrong; John H Fetting; M Katherine Carducci; Carol D Riley; John F Bender; Robert A Casero; Nancy E Davidson
A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(16 Pt 1):5922-8.
2003: Naveen Babbar; Natalia A Ignatenko; Robert A Casero; Eugene W Gerner
Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer.
The Journal of biological chemistry 2003;278(48):47762-75.
2003: Wendy Devereux; Yanlin Wang; Tracy Murray-Stewart; Amy Hacker; Renee Smith; Benjamin Frydman; Aldonia Valasinas; Venudhar Reddy; Laurence J Marton; Tracey D Ward; Patrick M Woster; Robert A Casero
Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells.
Cancer chemotherapy and pharmacology 2003;52(5):383-90.
2003: Tracy Murray-Stewart; Nancy B Applegren; Wendy Devereux; Amy Hacker; Renee Smith; Yanlin Wang; Robert A Casero
Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct.
The Biochemical journal 2003;373(Pt 2):629-34.
2003: Yi Huang; Erin R Hager; Dawn L Phillips; Valerie R Dunn; Amy Hacker; Benjamin Frydman; John A Kink; Aldonia Valasinas; Venudhar Reddy; Laurence J Marton; Robert A Casero; Nancy E Davidson
A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2769-77.
2003: Mi-Kyoung Kwak; Thomas W Kensler; Robert A Casero
Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein.
Biochemical and biophysical research communications 2003;305(3):662-70.
2003: Yanlin Wang; Tracy Murray-Stewart; Wendy Devereux; Amy Hacker; Benjamin Frydman; Patrick M Woster; Robert A Casero
Properties of purified recombinant human polyamine oxidase, PAOh1/SMO.
Biochemical and biophysical research communications 2003;304(4):605-11.
2003: Kamyar Zahedi; Zhaohui Wang; Sharon Barone; Anne E Prada; Caitlin N Kelly; Robert A Casero; Naoko Yokota; Carl W Porter; Hamid Rabb; Manoocher Soleimani
Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury.
American journal of physiology. Renal physiology 2003;284(5):F1046-55.
2003: Robert A Casero; Yanlin Wang; Tracy Murray-Stewart; Wendy Devereux; Amy Hacker; Yuchuan Wang; Renee Smith; Patrick M Woster
The role of polyamine catabolism in anti-tumour drug response.
Biochemical Society transactions 2003;31(2):361-5.
2002: Tracy Murray-Stewart; Yanlin Wang; Wendy Devereux; Robert A Casero
Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics.
The Biochemical journal 2002;368(Pt 3):673-7.
2002: Yanlin Wang; Wendy Devereux; Tracy Murray-Stewart; Robert A Casero
Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression.
The Biochemical journal 2002;366(Pt 1):79-86.
2002: Diane L Carlisle; Wendy Devereux; Amy Hacker; Patrick M Woster; Robert A Casero
Growth status significantly affects the response of human lung cancer cells to antitumor polyamine-analogue exposure.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2684-9.
2002: Kathryn R Lawson; Sarah Marek; Jennifer A Linehan; Patrick M Woster; Robert A Casero; Claire M Payne; Eugene W Gerner
Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1241-7.
2002: Alain Gobert; Yulan Cheng; Jian-Ying Wang; Jean-Luc Boucher; Ramaswamy Krishna Iyer; Stephen D Cederbaum; Robert A Casero; Jamie C Newton; Keith T Wilson
Helicobacter pylori induces macrophage apoptosis by activation of arginase II.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4692-700.
2002: Hillary A Hahm; David S Ettinger; Kathy Bowling; Beth Hoker; Tian Ling Chen; Yelena Zabelina; Robert A Casero
Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(3):684-90.
2001: Yanlin Wang; Wendy Devereux; Patrick M Woster; Robert A Casero
Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor.
The Biochemical journal 2001;359(Pt 2):387-92.
2001: Yanlin Wang; Wendy Devereux; Patrick M Woster; Tracy Murray-Stewart; Amy Hacker; Robert A Casero
Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure.
Cancer research 2001;61(14):5370-3.
2001: Joseph Satriano; Masato Isome; Robert A Casero; Scott C Thomson; Roland C Blantz
Polyamine transport system mediates agmatine transport in mammalian cells.
American journal of physiology. Cell physiology 2001;281(1):C329-34.
2001: Y Zou; Z Wu; NS Sirisoma; Patrick M Woster; Robert A Casero; Louis M Weiss; Donna Rattendi; Schennella Lane; Cyrus J Bacchi
Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity.
Bioorganic & medicinal chemistry letters 2001;11(12):1613-7.
2001: Yanlin Wang; Wendy Devereux; Tracy Murray-Stewart; Robert A Casero
Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene.
The Biochemical journal 2001;355(Pt 1):45-9.
2001: Hillary A Hahm; V R Dunn; KA Butash; W L Deveraux; Patrick M Woster; Robert A Casero; Nancy E Davidson
Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):391-9.
2001: Robert A Casero; Patrick M Woster
Terminally alkylated polyamine analogues as chemotherapeutic agents.
Journal of medicinal chemistry 2001;44(1):1-26.
2000: Hyo Chol Ha; A Thiagalingam; Barry D Nelkin; Robert A Casero
Reactive oxygen species are critical for the growth and differentiation of medullary thyroid carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3783-7.
2000: Diane E McCloskey; Patrick M Woster; Robert A Casero; Nancy E Davidson
Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):17-23.
1999: Yanlin Wang; Wendy Devereux; Tracy Murray-Stewart; Robert A Casero
Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene.
The Journal of biological chemistry 1999;274(31):22095-101.
1999: Edward Gabrielson; A E Pegg; Robert A Casero
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1638-41.
1999: H K Webb; Z Wu; NS Sirisoma; Hyo Chol Ha; Robert A Casero; Patrick M Woster
1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: simple synthetic polyamine analogues that differentially alter tubulin polymerization.
Journal of medicinal chemistry 1999;42(8):1415-21.
1999: Nancy E Davidson; Hillary A Hahm; Diane E McCloskey; Patrick M Woster; Robert A Casero
Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment.
Endocrine-related cancer 1999;6(1):69-73.
1998: Yanlin Wang; L Xiao; A Thiagalingam; Barry D Nelkin; Robert A Casero
The identification of a cis-element and a trans-acting factor involved in the response to polyamines and polyamine analogues in the regulation of the human spermidine/spermine N1-acetyltransferase gene transcription.
The Journal of biological chemistry 1998;273(51):34623-30.
1998: Hyo Chol Ha; NS Sirisoma; Periannan Kuppusamy; Jay L Zweier; Patrick M Woster; Robert A Casero
The natural polyamine spermine functions directly as a free radical scavenger.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11140-5.
1998: A R Mank-Seymour; Tracy Murray-Stewart; K A Berkey; L Xiao; Scott E Kern; Robert A Casero
Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(8):2003-8.
1998: Hyo Chol Ha; Patrick M Woster; Robert A Casero
Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in Bcl-2-overexpressing cells.
Cancer research 1998;58(13):2711-4.
1998: LF Barr; SE Campbell; P Tamez; Robert A Casero
The growth inhibitory effect of N1,N12-bis(ethyl)spermine in small cell lung cancer cells is maintained in cells expressing the c-myc and Ha-ras oncogenes.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(6):1557-61.
1998: Hyo Chol Ha; James D Yager; Patrick M Woster; Robert A Casero
Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species.
Biochemical and biophysical research communications 1998;244(1):298-303.
1998: C M Berchtold; P Tamez; Thomas W Kensler; Robert A Casero
Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels.
Journal of cellular physiology 1998;174(3):380-6.
1997: Jeremy R Graff; Arrigo De Benedetti; J W Olson; P Tamez; Robert A Casero; Stephen G Zimmer
Translation of ODC mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation factor 4E.
Biochemical and biophysical research communications 1997;240(1):15-20.
1997: Hyo Chol Ha; Patrick M Woster; James D Yager; Robert A Casero
The role of polyamine catabolism in polyamine analogue-induced programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11557-62.
1997: Francis M Giardiello; Stanley R Hamilton; Linda M Hylind; Yang Vincent; P Tamez; Robert A Casero
Ornithine decarboxylase and polyamines in familial adenomatous polyposis.
Cancer research 1997;57(2):199-201.
1996: L Lu; K A Berkey; Robert A Casero
RGFGIGS is an amino acid sequence required for acetyl coenzyme A binding and activity of human spermidine/spermine N1acetyltransferase.
The Journal of biological chemistry 1996;271(31):18920-4.
1996: R Wu; N H Saab; H Huang; L Wiest; Anthony E Pegg; Robert A Casero; Patrick M Woster
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase.
Bioorganic & medicinal chemistry 1996;4(6):825-36.
1996: Mieke Schutte; Ralph Hruban; L Hedrick; Kathleen R Cho; G M Nadasdy; C L Weinstein; G Steven Bova; William B Isaacs; Paul Cairns; H Nawroz; David Sidransky; Robert A Casero; P S Meltzer; Stephan Hahn; Scott E Kern
DPC4 gene in various tumor types.
Cancer research 1996;56(11):2527-30.
1996: Diane E McCloskey; J Yang; Patrick M Woster; Nancy E Davidson; Robert A Casero
Polyamine analogue induction of programmed cell death in human lung tumor cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):441-6.
1996: L Xiao; Robert A Casero
Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells.
The Biochemical journal 1996;313 ( Pt 2)():691-6.
1996: D Shao; L Xiao; Hyo Chol Ha; Robert A Casero
Isolation of a polyamine transport deficient cell line from the human non-small cell lung carcinoma line NCI H157.
Journal of cellular physiology 1996;166(1):43-8.
1995: J Yang; L Xiao; K A Berkey; P Tamez; J K Coward; Robert A Casero
Significant induction of spermidine/spermine N1-acetyltransferase without cytotoxicity by the growth-supporting polyamine analogue 1,12-dimethylspermine.
Journal of cellular physiology 1995;165(1):71-6.
1995: Gad Gilad; V H Gilad; M F Casanova; Robert A Casero
Polyamines and their metabolizing enzymes in human frontal cortex and hippocampus: preliminary measurements in affective disorders.
Biological psychiatry 1995;38(4):227-34.
1995: Diane E McCloskey; Robert A Casero; Patrick M Woster; Nancy E Davidson
Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue.
Cancer research 1995;55(15):3233-6.
1995: Fulvio Della Ragione; G Russo; Adriana Oliva; S Mastropietro; A Mancini; A Borrelli; Robert A Casero; Achille Iolascon; Vincenzo Zappia
5'-Deoxy-5'-methylthioadenosine phosphorylase and p16INK4 deficiency in multiple tumor cell lines.
Oncogene 1995;10(5):827-33.
1995: Robert A Casero; A R Mank; N H Saab; R Wu; W J Dyer; Patrick M Woster
Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1.
Cancer chemotherapy and pharmacology 1995;36(1):69-74.
1994: M Eileen Dolan; M J Fleig; Burt Feuerstein; H S Basu; GD Luk; Robert A Casero; L J Marton
Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.
Cancer research 1994;54(17):4698-702.
1994: Robert A Casero; Edward Gabrielson; Anthony E Pegg
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.
Cancer research 1994;54(15):3955-8.
1994: J R Williams; Robert A Casero; L E Dillehay
The effect of polyamine depletion on the cytotoxic response to PUVA, gamma rays and UVC in V79 cells in vitro.
Biochemical and biophysical research communications 1994;201(1):1-7.
1994: G M Gilad; V H Gilad; Robert A Casero
Lithium exerts a time-dependent and tissue-selective attenuation of the dexamethasone-induced polyamine response in rat brain and liver.
Brain research 1994;636(2):187-92.
1993: M Fogel-Petrovic; Debora L Kramer; B Ganis; Robert A Casero; Carl W Porter
Cloning and sequence analysis of the gene and cDNA encoding mouse spermidine/spermine N1-acetyltransferase--a gene uniquely regulated by polyamines and their analogs.
Biochimica et biophysica acta 1993;1216(2):255-64.
1993: N H Saab; E E West; N C Bieszk; C V Preuss; A R Mank; Robert A Casero; Patrick M Woster
Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents.
Journal of medicinal chemistry 1993;36(20):2998-3004.
1993: Eugene W Gerner; T A Kurtts; D J Fuller; Robert A Casero
Stress induction of the spermidine/spermine N1-acetyltransferase by a post-transcriptional mechanism in mammalian cells.
The Biochemical journal 1993;294 ( Pt 2)():491-5.
1993: P Celano; Paula M Vertino; Robert A Casero
Isolation of polyadenylated RNA from cultured cells and intact tissues.
BioTechniques 1993;15(1):26-8.
1993: Robert A Casero; Anthony E Pegg
Spermidine/spermine N1-acetyltransferase--the turning point in polyamine metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(8):653-61.
1993: Nancy E Davidson; A R Mank; L J Prestigiacomo; R J Bergeron; Robert A Casero
Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine.
Cancer research 1993;53(9):2071-5.
1993: P Celano; C M Berchtold; M Mabry; M Carroll; David Sidransky; Robert A Casero; R Lupu
Induction of markers of normal differentiation in human colon carcinoma cells by the v-rasH oncogene.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(4):341-7.
1993: Gad Gilad; Robert A Casero; R Busto; M Y Globus
Polyamines in rat brain extracellular space after ischemia.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1993;18(1-2):27-33.
1992: Anthony E Pegg; Bruce Stanley; L Wiest; Robert A Casero
Nucleotide sequence of hamster spermidine/spermine-N1-acetyltransferase cDNA.
Biochimica et biophysica acta 1992;1171(1):106-8.
1992: Robert A Casero; A R Mank; L Xiao; J Smith; R J Bergeron; P Celano
Steady-state messenger RNA and activity correlates with sensitivity to N1,N12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer.
Cancer research 1992;52(19):5359-63.
1992: L Xiao; P Celano; A R Mank; Constance A Griffin; Ethylin Jabs; Anita L Hawkins; Robert A Casero
Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1).
Biochemical and biophysical research communications 1992;187(3):1493-502.
1992: P Celano; C M Berchtold; D L Kizer; A Weeraratna; Barry D Nelkin; Stephen B Baylin; Robert A Casero
Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene.
The Journal of biological chemistry 1992;267(21):15092-6.
1992: Daniel T Laskowitz; GB Elion; Mark Dewhirst; O W Griffith; Robert A Casero; P A Scott; Nancy S Bullock; Darell D Bigner; Henry S Friedman
Effects of glutathione or polyamine depletion on in vivo thermosensitization.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1992;8(2):199-208.
1992: Anna Mae Diehl; Shi Qi Yang; N Brown; J Smith; D Raiford; R Gordon; Robert A Casero
Ethanol-associated alterations in the kinetics of putrescine uptake and metabolism by the regenerating liver.
Alcoholism, clinical and experimental research 1992;16(1):5-10.
1992: Gad Gilad; V H Gilad; RJ Wyatt; Robert A Casero
Chronic lithium treatment prevents the dexamethasone-induced increase of brain polyamine metabolizing enzymes.
Life sciences 1992;50(18):PL149-54.
1991: L Xiao; P Celano; A R Mank; Anthony E Pegg; Robert A Casero
Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase.
Biochemical and biophysical research communications 1991;179(1):407-15.
1991: SC Marks; Douglas E Mattox; Robert A Casero
The effects of DFMO on polyamine metabolism in the inner ear.
Hearing research 1991;53(2):230-6.
1991: Robert A Casero; P Celano; S J Ervin; N B Applegren; L Wiest; Anthony E Pegg
Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1991;266(2):810-4.
1990: Robert A Casero; P Celano; S J Ervin; L Wiest; Anthony E Pegg
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.
The Biochemical journal 1990;270(3):615-20.
1989: P Celano; C M Berchtold; Francis M Giardiello; Robert A Casero
Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells.
Biochemical and biophysical research communications 1989;165(1):384-90.
1989: P Celano; C Berchtold; Robert A Casero
A simplification of the nuclear run-off transcription assay.
BioTechniques 1989;7(9):942, 944.
1989: Robert A Casero; P Celano; S J Ervin; C W Porter; R J Bergeron; P R Libby
Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues.
Cancer research 1989;49(14):3829-33.
1989: P Celano; Stephen B Baylin; Robert A Casero
Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells.
The Journal of biological chemistry 1989;264(15):8922-7.
1989: Robert A Casero; S J Ervin; P Celano; Stephen B Baylin; R J Bergeron
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.
Cancer research 1989;49(3):639-43.
1988: M Mabry; T Nakagawa; Barry D Nelkin; E McDowell; M Gesell; J C Eggleston; Robert A Casero; Stephen B Baylin
v-Ha-ras oncogene insertion: a model for tumor progression of human small cell lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6523-7.
1988: P Celano; Stephen B Baylin; Francis M Giardiello; Barry D Nelkin; Robert A Casero
Effect of polyamine depletion on c-myc expression in human colon carcinoma cells.
The Journal of biological chemistry 1988;263(12):5491-4.
1987: S C Denstman; S J Ervin; Robert A Casero
Comparison of the effects of treatment with the polyamine analogue N1,N8 bis(ethyl)spermidine (BESpd) or difluoromethylornithine (DFMO) on the Topoisomerase II mediated formation of 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA) induced cleavable complex in the human lung carcinoma line NCI H157.
Biochemical and biophysical research communications 1987;149(1):194-202.
1987: Robert A Casero; B Go; H W Theiss; J Smith; Stephen B Baylin; GD Luk
Cytotoxic response of the relatively difluoromethylornithine-resistant human lung tumor cell line NCI H157 to the polyamine analogue N1,N8-bis(ethyl)spermidine.
Cancer research 1987;47(15):3964-7.
1987: Carl W Porter; James S McManis; Robert A Casero; Raymond J Bergeron
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth.
Cancer research 1987;47(11):2821-5.
1987: GD Luk; Robert A Casero
Polyamines in normal and cancer cells.
Advances in enzyme regulation 1987;26():91-105.
1986: Robert A Casero; Stephen B Baylin; Barry D Nelkin; GD Luk
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
Biochemical and biophysical research communications 1986;134(2):572-9.
1984: Robert A Casero; R J Bergeron; C W Porter
Treatment with alpha-difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured L1210 leukemia cells.
Journal of cellular physiology 1984;121(3):476-82.
1982: Robert A Casero; C W Porter; R J Bernacki
Activity of tunicamycin against Trypanosoma brucei in vitro and in vivo.
Antimicrobial agents and chemotherapy 1982;22(6):1008-11.
1980: R E Desjardins; Robert A Casero; G P Willet; G E Childs; CJ Canfield
Trypanosoma rhodesiense: semiautomated microtesting for quantitation of antitrypanosomal activity in vitro.
Experimental parasitology 1980;50(2):260-71.
1980: Robert A Casero; D L Klayman; G E Childs; J P Scovill; R E Desjardins
Activity of 2-acetylpyridine thiosemicarbazones against Trypanosoma rhodesiense in vitro.
Antimicrobial agents and chemotherapy 1980;18(2):317-22.