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Bruce Frank

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TOP 3
Qing-xin Hua; Wenhua Jia; Bruce Frank; Nelson F B Phillips; Michael A Weiss
A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers.
Michael R Defelippis; Ronald E Chance; Bruce Frank
Insulin self-association and the relationship to pharmacokinetics and pharmacodynamics.
MP Stickelmeyer; C J Graf; Bruce Frank; R L Ballard; S M Storms
Stability of U-10 and U-50 dilutions of insulin lispro.

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All Publications

2002: Qing-xin Hua; Wenhua Jia; Bruce Frank; Nelson F B Phillips; Michael A Weiss
A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers.
Biochemistry 2002;41(50):14700-15.
2001: Michael R Defelippis; Ronald E Chance; Bruce Frank
Insulin self-association and the relationship to pharmacokinetics and pharmacodynamics.
Critical reviews in therapeutic drug carrier systems 2001;18(2):201-64.
2000: MP Stickelmeyer; C J Graf; Bruce Frank; R L Ballard; S M Storms
Stability of U-10 and U-50 dilutions of insulin lispro.
Diabetes technology & therapeutics 2000;2(1):61-6.
2000: Christopher M Yip; Mark L Brader; Bruce Frank; Michael R Defelippis; MD Ward
Structural studies of a crystalline insulin analog complex with protamine by atomic force microscopy.
Biophysical journal 2000;78(1):466-73.
1999: J P Richards; MP Stickelmeyer; Bruce Frank; S Pye; M Barbeau; Jerry Radziuk; G D Smith; Michael R Defelippis
Preparation of a microcrystalline suspension formulation of Lys(B28)Pro(B29)-human insulin with ultralente properties.
Journal of pharmaceutical sciences 1999;88(9):861-7.
1999: Frederick G Hamel; Gerri L Siford; Janet Fawcett; Ronald E Chance; Bruce Frank; William C Duckworth
Differences in the cellular processing of AspB10 human insulin compared with human insulin and LysB28ProB29 human insulin.
Metabolism: clinical and experimental 1999;48(5):611-7.
1999: R C Beavis; M D Kneirman; D Sharknas; M A Heady; Bruce Frank; Michael R Defelippis
A novel protein cross-linking reaction in stressed Neutral Protamine Hagedorn formulations of insulin.
Journal of pharmaceutical sciences 1999;88(3):331-6.
1998: D R Shnek; D L Hostettler; Maureen A Bell; J M Olinger; Bruce Frank
Physical stress testing of insulin suspensions and solutions.
Journal of pharmaceutical sciences 1998;87(11):1459-65.
1998: J P Richards; MP Stickelmeyer; David B Flora; Ronald E Chance; Bruce Frank; Michael R Defelippis
Self-association properties of monomeric insulin analogs under formulation conditions.
Pharmaceutical research 1998;15(9):1434-41.
1998: Christopher M Yip; Michael R Defelippis; Bruce Frank; Mark L Brader; MD Ward
Structural and morphological characterization of ultralente insulin crystals by atomic force microscopy: evidence of hydrophobically driven assembly.
Biophysical journal 1998;75(3):1172-9.
1998: P Houssa; B Dinesen; Michelle A Deberg; Bruce Frank; Chris Van Schravendijk; F Sodoyez-Goffaux; JC Sodoyez
First direct assay for intact human proinsulin.
Clinical chemistry 1998;44(7):1514-9.
1998: Michelle A Deberg; P Houssa; Bruce Frank; F Sodoyez-Goffaux; JC Sodoyez
Highly specific radioimmunoassay for human insulin based on immune exclusion of all insulin precursors.
Clinical chemistry 1998;44(7):1504-13.
1998: Michael R Defelippis; D L Bakaysa; Maureen A Bell; M A Heady; S Li; S Pye; K M Youngman; Jerry Radziuk; Bruce Frank
Preparation and characterization of a cocrystalline suspension of [LysB28,ProB29]-human insulin analogue.
Journal of pharmaceutical sciences 1998;87(2):170-6.
1998: Bruce Frank
The development of recombinant human insulin.
Developments in biological standardization 1998;96():91-5.
1997: W D Lougheed; B Zinman; T R Strack; L J Janis; A B Weymouth; E A Bernstein; A M Korbas; Bruce Frank
Stability of insulin lispro in insulin infusion systems.
Diabetes care 1997;20(7):1061-5.
1996: Qing-xin Hua; S Q Hu; Bruce Frank; W Jia; Y C Chu; S H Wang; G T Burke; P G Katsoyannis; Michael A Weiss
Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
Journal of molecular biology 1996;264(2):390-403.
1996: E Jacoby; Qing-xin Hua; A S Stern; Bruce Frank; Michael A Weiss
Structure and dynamics of a protein assembly. 1H-NMR studies of the 36 kDa R6 insulin hexamer.
Journal of molecular biology 1996;258(1):136-57.
1995: E Ciszak; John M Beals; Bruce Frank; J C Baker; N D Carter; G D Smith
Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin.
Structure (London, England : 1993) 1995;3(6):615-22.
1995: Qing-xin Hua; S N Gozani; R E Chance; J A Hoffmann; Bruce Frank; Michael A Weiss
Structure of a protein in a kinetic trap.
Nature structural biology 1995;2(2):129-38.
1993: Ronald E Chance; Bruce Frank
Research, development, production, and safety of biosynthetic human insulin.
Diabetes care 1993;16 Suppl 3():133-42.
1993: Qing-xin Hua; W Jia; Bruce Frank; Michael A Weiss
Comparison of the dynamics of an engineered insulin monomer and dimer by acid-quenched amide proton exchange. Non-local stabilization of interchain hydrogen bonds by dimerization.
Journal of molecular biology 1993;230(2):387-94.
1992: R R Bowsher; J D Wolny; Bruce Frank
A rapid and sensitive radioimmunoassay for the measurement of proinsulin in human serum.
Diabetes 1992;41(9):1084-90.
1992: D N Brems; L A Alter; M J Beckage; Ronald E Chance; Richard D Dimarchi; L K Green; H B Long; A H Pekar; J E Shields; Bruce Frank
Altering the association properties of insulin by amino acid replacement.
Protein engineering 1992;5(6):527-33.
1992: D N Brems; P L Brown; C Bryant; Ronald E Chance; L K Green; H B Long; A A Miller; R Millican; J E Shields; Bruce Frank
Improved insulin stability through amino acid substitution.
Protein engineering 1992;5(6):519-25.
1992: J A Galloway; S A Hooper; C T Spradlin; D C Howey; Bruce Frank; R R Bowsher; J H Anderson
Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience.
Diabetes care 1992;15(5):666-92.
1991: Michael A Weiss; Qing-xin Hua; C S Lynch; Bruce Frank; Steven E Shoelson
Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design.
Biochemistry 1991;30(30):7373-89.
1991: B Burguera; Bruce Frank; R DiMarchi; S Long; JF Caro
The interaction of proinsulin with the insulin-like growth factor-I receptor in human liver, muscle, and adipose tissue.
The Journal of clinical endocrinology and metabolism 1991;72(6):1238-41.
1990: D C Dahl; Tanny Tsao; William C Duckworth; Bruce Frank; Ralph Rabkin
Effect of bacitracin on retroendocytosis and degradation of insulin in cultured kidney epithelial cell line.
Diabetes 1990;39(11):1339-46.
1990: H Tillil; Bruce Frank; A H Pekar; C Broelsch; Arthur H Rubenstein; Kenneth S Polonsky
Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites.
Endocrinology 1990;127(5):2418-22.
1990: D N Brems; P L Brown; L A Heckenlaible; Bruce Frank
Equilibrium denaturation of insulin and proinsulin.
Biochemistry 1990;29(39):9289-93.
1990: Michael A Weiss; Bruce Frank; Igor Khait; A Pekar; R Heiney; Steven E Shoelson; L J Neuringer
NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition.
Biochemistry 1990;29(36):8389-401.
1990: S M Sumner; P A Grau; Bruce Frank
Agency nurse vs. IRS: are you an employee, an independent contractor, or both?
The American journal of nursing 1990;90(3):25-6.
1989: Michael A Weiss; D T Nguyen; Igor Khait; K Inouye; Bruce Frank; M Beckage; E O'Shea; Steven E Shoelson; M Karplus; L J Neuringer
Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics.
Biochemistry 1989;28(25):9855-73.
1989: W J Sobey; S F Beer; C A Carrington; P M Clark; Bruce Frank; I P Gray; S D Luzio; D R Owens; A E Schneider; Kenneth Siddle
Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins.
The Biochemical journal 1989;260(2):535-41.
1989: William C Duckworth; J V Garcia; J J Liepnieks; Frederick G Hamel; M A Hermodson; Bruce Frank; Marsha Rich Rosner
Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites.
Biochemistry 1989;28(6):2471-7.
1988: William C Duckworth; Frederick G Hamel; J Liepnieks; Bruce Frank; C Yagil; Ralph Rabkin
High performance liquid chromatographic analysis of insulin degradation products from a cultured kidney cell line.
Endocrinology 1988;123(6):2701-8.
1988: F Sodoyez-Goffaux; J C Sodoyez; M Koch; C J De Vos; Bruce Frank
Scintigraphic distribution of 123 I labelled proinsulin, split conversion intermediates and insulin in rats.
Diabetologia 1988;31(11):848-54.
1988: William C Duckworth; D E Peavy; Frederick G Hamel; J Liepnieks; M R Brunner; R E Heiney; Bruce Frank
Conversion of biosynthetic human proinsulin to partially cleaved intermediates by collagenase proteinases adsorbed to isolated rat adipocytes.
The Biochemical journal 1988;255(1):277-84.
1988: W R Gilbert; Bruce Frank; J R Gavin; RL Gingerich
Characterization of specific pancreatic polypeptide receptors on basolateral membranes of the canine small intestine.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4745-9.
1988: P A Gruppuso; Bruce Frank; R Schwartz
Binding of proinsulin and proinsulin conversion intermediates to human placental insulin-like growth factor I receptors.
The Journal of clinical endocrinology and metabolism 1988;67(1):194-7.
1988: C Yagil; Bruce Frank; Ralph Rabkin
Effect of bacitracin on binding and processing of insulin by established renal cell line.
Diabetes 1988;37(6):800-5.
1988: C Yagil; Bruce Frank; Ralph Rabkin
Internalization and catabolism of insulin by an established renal cell line.
The American journal of physiology 1988;254(6 Pt 1):C822-8.
1988: Charles F Burant; M K Treutelaar; D E Peavy; Bruce Frank; Maria G Buse
Differential binding of monoiodinated insulins to muscle and liver derived receptors and activation of the receptor kinase.
Biochemical and biophysical research communications 1988;152(3):1353-60.
1988: Frederick G Hamel; Barry Posner; J J Bergeron; Bruce Frank; William C Duckworth
Isolation of insulin degradation products from endosomes derived from intact rat liver.
The Journal of biological chemistry 1988;263(14):6703-8.
1988: Kenneth S Polonsky; B D Given; L J Hirsch; H Tillil; E T Shapiro; C Beebe; Bruce Frank; J A Galloway; Eve Van Cauter
Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.
The New England journal of medicine 1988;318(19):1231-9.
1988: C Yagil; U K Ehmann; Bruce Frank; Ralph Rabkin
Insulin binding, internalization, and degradation by a cultured kidney cell line.
The American journal of physiology 1988;254(5 Pt 1):E601-8.
1988: J Herrman; R E Simmons; Bruce Frank; Ralph Rabkin
Differences in renal metabolism of insulin and cytochrome c.
The American journal of physiology 1988;254(4 Pt 1):E419-28.
1988: S Edwin Fineberg; M J Rathbun; S Hufferd; Naomi S Fineberg; C T Spradlin; J A Galloway; Bruce Frank
Immunologic aspects of human proinsulin therapy.
Diabetes 1988;37(3):276-80.
1988: H Tillil; E T Shapiro; M A Miller; T Karrison; Bruce Frank; J A Galloway; Arthur H Rubenstein; Kenneth S Polonsky
Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans.
The American journal of physiology 1988;254(3 Pt 1):E349-57.
1988: William C Duckworth; Frederick G Hamel; D E Peavy; J J Liepnieks; M P Ryan; M A Hermodson; Bruce Frank
Degradation products of insulin generated by hepatocytes and by insulin protease.
The Journal of biological chemistry 1988;263(4):1826-33.
1988: Kenneth S Polonsky; B D Given; L Hirsch; E T Shapiro; H Tillil; C Beebe; J A Galloway; Bruce Frank; T Karrison; Eve Van Cauter
Quantitative study of insulin secretion and clearance in normal and obese subjects.
The Journal of clinical investigation 1988;81(2):435-41.
1987: E T Shapiro; H Tillil; M A Miller; Bruce Frank; J A Galloway; Arthur H Rubenstein; Kenneth S Polonsky
Insulin secretion and clearance. Comparison after oral and intravenous glucose.
Diabetes 1987;36(12):1365-71.
1987: William C Duckworth; Frederick G Hamel; J J Liepnieks; D E Peavy; M P Ryan; M A Hermodson; Bruce Frank
Identification of A chain cleavage sites in intact insulin produced by insulin protease and isolated hepatocytes.
Biochemical and biophysical research communications 1987;147(2):615-21.
1987: I P Gray; Kenneth Siddle; Bruce Frank; C N Hales
Characterization and use in immunoradiometric assay of monoclonal antibodies directed against human proinsulin.
Diabetes 1987;36(6):684-8.
1987: R M Cohen; Julio Licinio; Kenneth S Polonsky; J A Galloway; Bruce Frank; A D Cherrington; Arthur H Rubenstein
The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes.
The Journal of clinical endocrinology and metabolism 1987;64(3):476-81.
1987: H S Glauber; Robert R Henry; P Wallace; Bruce Frank; J A Galloway; R M Cohen; J M Olefsky
The effects of biosynthetic human proinsulin on carbohydrate metabolism in non-insulin-dependent diabetes mellitus.
The New England journal of medicine 1987;316(8):443-9.
1986: R M Cohen; B D Given; Julio Licinio; S A Provow; P A Rue; Bruce Frank; M A Root; Kenneth S Polonsky; H S Tager; Arthur H Rubenstein
Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia.
Metabolism: clinical and experimental 1986;35(12):1137-46.
1986: R Rabkin; P Hirayama; R A Roth; Bruce Frank
Effect of experimental diabetes on insulin binding by renal basolateral membranes.
Kidney international 1986;30(3):348-54.
1986: W R Gilbert; J L Kramer; Bruce Frank; RL Gingerich
Intestinal mucosa is a target tissue for pancreatic polypeptide.
Endocrinology 1986;118(6):2495-9.
1986: W Kenneth Ward; T L Paquette; Bruce Frank; Daniel Porte
A sensitive radioimmunoassay for human proinsulin, with sequential use of antisera to C-peptide and insulin.
Clinical chemistry 1986;32(5):728-33.
1986: H S Glauber; P Wallace; J Galloway; Bruce Frank; J M Olefsky
The effects of proinsulin pretreatment on the combined actions of insulin and proinsulin in normal man.
The Journal of clinical endocrinology and metabolism 1986;62(4):785-8.
1986: H S Glauber; R R Revers; R Henry; L Schmeiser; P Wallace; O G Kolterman; R M Cohen; Arthur H Rubenstein; J A Galloway; Bruce Frank
In vivo deactivation of proinsulin action on glucose disposal and hepatic glucose production in normal man.
Diabetes 1986;35(3):311-7.
1985: M S Kappy; D W Clarke; M K Raizada; F T Boyd; Bruce Frank
Developing rat brain binds monoiodinated insulin isomers similarly to other extrahepatic target tissues.
Brain research 1985;360(1-2):195-202.
1985: D E Peavy; M R Brunner; William C Duckworth; C S Hooker; Bruce Frank
Receptor binding and biological potency of several split forms (conversion intermediates) of human proinsulin. Studies in cultured IM-9 lymphocytes and in vivo and in vitro in rats.
The Journal of biological chemistry 1985;260(26):13989-94.
1985: B D Given; R M Cohen; S E Shoelson; Bruce Frank; Arthur H Rubenstein; H S Tager
Biochemical and clinical implications of proinsulin conversion intermediates.
The Journal of clinical investigation 1985;76(4):1398-405.
1985: John Cottrell; Bruce Frank
Fast atom bombardment mass spectrometry of bovine proinsulin.
Biochemical and biophysical research communications 1985;127(3):1032-8.
1985: K A Heidenreich; C C Yip; Bruce Frank; J M Olefsky
The preparation and characterization of mono-iodinated photoreactive analogs of insulin.
Biochemical and biophysical research communications 1985;126(3):1138-45.
1985: R M Cohen; T Nakabayashi; P M Blix; P A Rue; S E Shoelson; M A Root; Bruce Frank; R R Revers; Arthur H Rubenstein
A radioimmunoassay for circulating human proinsulin.
Diabetes 1985;34(1):84-91.
1984: D E Peavy; J D Abram; Bruce Frank; W C Duckworth
In vitro activity of biosynthetic human proinsulin. Receptor binding and biologic potency of proinsulin and insulin in isolated rat adipocytes.
Diabetes 1984;33(11):1062-7.
1984: O D Madsen; Bruce Frank; D F Steiner
Human proinsulin-specific antigenic determinants identified by monoclonal antibodies.
Diabetes 1984;33(10):1012-6.
1984: V Kruse; L G Heding; K H Jørgensen; B Tronier; M Christensen; L Thim; Bruce Frank; M A Root; R M Cohen; Arthur H Rubenstein
Human proinsulin standards.
Diabetologia 1984;27(3):414-5.
1984: M P Ryan; D E Peavy; Bruce Frank; W C Duckworth
The degradation of monoiodotyrosyl insulin isomers by insulin protease.
Endocrinology 1984;115(2):591-9.
1984: I P Gray; Kenneth Siddle; K Docherty; Bruce Frank; C N Hales
Proinsulin in human serum: problems in measurement and interpretation.
Clinical endocrinology 1984;21(1):43-7.
1984: Bruce Frank; A H Pekar; J M Pettee; E M Schirmer; M G Johnson; Ronald E Chance
Isolation and characterization of a genetic variant of bovine proinsulin.
International journal of peptide and protein research 1984;23(5):506-15.
1984: D E Peavy; J D Abram; Bruce Frank; W C Duckworth
Receptor binding and biological activity of specifically labeled [125I]- and [127I]monoiodoinsulin isomers in isolated rat adipocytes.
Endocrinology 1984;114(5):1818-24.
1984: D A Podlecki; Bruce Frank; J M Olefsky
In vitro characterization of biosynthetic human proinsulin.
Diabetes 1984;33(2):111-8.
1983: A Green; Bruce Frank; Arthur H Rubenstein; H Tager; J M Olefsky
Characteristics of binding of a low affinity, noncooperative insulin [( LeuB25]insulin) to IM-9 lymphocytes.
Endocrinology 1983;113(6):1963-71.
1983: Bruce Frank; M J Beckage; K A Willey
High-performance liquid chromatographic preparation of single-site carrier-free pancreatic polypeptide hormone radiotracers.
Journal of chromatography 1983;266():239-48.
1983: Bruce Frank; D E Peavy; C S Hooker; William C Duckworth
Receptor binding properties of monoiodotyrosyl insulin isomers purified by high performance liquid chromatography.
Diabetes 1983;32(8):705-11.
1983: D A Podlecki; Bruce Frank; M Kao; H Horikoshi; G Freidenberg; S Marshall; T Ciaraldi; J M Olefsky
Characterization of the receptor binding properties of monoiodoinsulin isomers and the identification of different insulin receptor specificities in hepatic and extrahepatic tissues.
Diabetes 1983;32(8):697-704.
1983: Bruce Frank; R E Chance
Two routes for producing human insulin utilizing recombinant DNA technology.
MMW, Münchener medizinische Wochenschrift 1983;Suppl 1():S14-20.
1981: R E Chance; E P Kroeff; J A Hoffmann; Bruce Frank
Chemical, physical, and biologic properties of biosynthetic human insulin.
Diabetes care 1981;4(2):147-54.
1975: J P Burnett; Bruce Frank; R J Douthart
Ionic strength effects on the stability and conformation of Penicillium chrysogenum mycophage double stranded RNA.
Nucleic acids research 1975;2(6):759-71.
1974: Bruce Frank; A H Pekar
Physical properties of nitroglucagons and aminoglucagons.
The Journal of biological chemistry 1974;249(15):4846-50.
1973: R J Douthart; J P Burnett; F W Beasley; Bruce Frank
Binding of ethidium bromide to double-stranded ribonucleic acid.
Biochemistry 1973;12(2):214-20.
1972: Bruce Frank; A J Veros; A H Pekar
Physical studies on proinsulin. A comparison of the titration behavior of the tyrosine residues in insulin and proinsulin.
Biochemistry 1972;11(26):4926-31.
1972: A H Pekar; Bruce Frank
Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH.
Biochemistry 1972;11(22):4013-6.
1972: W W Bromer; M E Boucher; J M Patterson; A H Pekar; Bruce Frank
Glucagon structure and function. I. Purification and properties of bovine glucagon and monodesmidoglucagon.
The Journal of biological chemistry 1972;247(8):2581-5.
1972: P T Grant; T L Coombs; Bruce Frank
Differences in the nature of the interaction of insulin and proinsulin with zinc.
The Biochemical journal 1972;126(2):433-40.
1972: Bruce Frank; A H Pekar; A J Veros
Insulin and proinsulin conformation in solution.
Diabetes 1972;21(2 Suppl):486-91.
1971: T L Coombs; P T Grant; Bruce Frank
Differences in the binding of zinc ions by insulin and proinsulin.
The Biochemical journal 1971;125(3):62P-63P.
1971: A H Pekar; R E Weller; R A Byers; Bruce Frank
On-line data acquisition from the ultracentrifuge.
Analytical biochemistry 1971;42(2):516-29.
1970: Bruce Frank; A H Pekar; A J Veros; P P Ho
Crystalline L-asparaginase from Escherichia coli B. II. Physical properties, subunits, and reconstitution behavior.
The Journal of biological chemistry 1970;245(14):3716-24.
1970: P P Ho; E B Milikin; J L Bobbitt; E L Grinnan; P J Burck; Bruce Frank; L D Boeck; R W Squires
Crystalline L-asparaginase from Escherichia coli B. I. Purification and chemical characterization.
The Journal of biological chemistry 1970;245(14):3708-15.
1970: Bruce Frank; A J Veros
Interaction of zinc with proinsulin.
Biochemical and biophysical research communications 1970;38(2):284-9.
1969: P P Ho; Bruce Frank; P J Burck
Crystalline L-asparaginase from escherichia coli B.
Science (New York, N.Y.) 1969;165(3892):510-2.
1968: Bruce Frank; A J Veros
Physical studies on proinsulin-association behavior and conformation in solution.
Biochemical and biophysical research communications 1968;32(2):155-60.
1965: I M KLOTZ; Bruce Frank
DEUTERIUM--HYDROGEN EXCHANGE IN AMIDE N--H GROUPS.
Journal of the American Chemical Society 1965;87():2721-8.
1962: I M Klotz; Bruce Frank
Catalysis by Imidazole of Deuterium-Hydrogen Exchange in Amide N-H Groups.
Science (New York, N.Y.) 1962;138(3542):830-1.