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Patrick Casey

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Anatomy

Cell Line

Living Beings

Rats
Mice

Phenomena

Protein Binding

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Co-Publications
Name
11
Bergo, Martin
9
Fields, Timothy
9
Beese, Lorena
9
Kelly, Patrick
9
Otto, James
8
Young, Stephen
7
Meigs, Thomas
5
Fierke, Carol
5
Ambroziak, Patricia
5
Kaplan, Daniel
5
Tschantz, William
4
Nixon, Andrew
4
Zhang, Lisheng
4
Hightower, KE
4
Stemmle, Laura

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Publications

TOP 3
Rossol-Allison Jessica; Stemmle Laura N; Swenson-Fields Katherine I; Kelly Patrick; Fields Patrick E; McCall Shannon J; Casey Patrick J; Fields Timothy A
Rho GTPase activity modulates Wnt3a/beta-catenin signaling.
Cushman Ian; Casey Patrick J
Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.
Juneja Juhi; Casey Patrick J
Role of G12 proteins in oncogenesis and metastasis.

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All Publications

2009: Rossol-Allison Jessica; Stemmle Laura N; Swenson-Fields Katherine I; Kelly Patrick; Fields Patrick E; McCall Shannon J; Casey Patrick J; Fields Timothy A
Rho GTPase activity modulates Wnt3a/beta-catenin signaling.
Cellular signalling 2009;21(11):1559-68.
2009: Cushman Ian; Casey Patrick J
Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.
The Journal of biological chemistry 2009;284(41):27964-73.
2009: Juneja Juhi; Casey Patrick J
Role of G12 proteins in oncogenesis and metastasis.
British journal of pharmacology 2009;158(1):32-40.
2009: Peterson Yuri K; Wang Xiang S; Casey Patrick J; Tropsha Alexander
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation.
Journal of medicinal chemistry 2009;52(14):4210-20.
2009: Bailey Candice L; Kelly Patrick; Casey Patrick J
Activation of Rap1 promotes prostate cancer metastasis.
Cancer research 2009;69(12):4962-8.
2008: Williams R Sanders; Casey Patrick J; Kamei Robert K; Buckley Edward G; Soo Khee Chee; Merson Michael H; Krishnan Ranga K; Dzau Victor J
A global partnership in medical education between Duke University and the National University of Singapore.
Academic medicine : journal of the Association of American Medical Colleges 2008;83(2):122-7.
2008: Kimple Michelle E; Joseph Jamie W; Bailey Candice L; Fueger Patrick T; Hendry Ian A; Newgard Christopher B; Casey Patrick J
Galphaz negatively regulates insulin secretion and glucose clearance.
The Journal of biological chemistry 2008;283(8):4560-7.
2008: Bahmanyar Shirin; Kaplan Daniel D; Deluca Jennifer G; Giddings Thomas H; O'Toole Eileen T; Winey Mark; Salmon Edward D; Casey Patrick J; Nelson W James; Barth Angela I M
beta-Catenin is a Nek2 substrate involved in centrosome separation.
Genes & development 2008;22(1):91-105.
2007: Kelly Patrick; Casey Patrick J; Meigs Thomas E
Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.
Biochemistry 2007;46(23):6677-87.
2007: Sjogren Anna-Karin M; Andersson Karin M E; Liu Meng; Cutts Briony A; Karlsson Christin; Wahlstrom Annika M; Dalin Martin; Weinbaum Carolyn; Casey Patrick J; Tarkowski Andrej; Swolin Birgitta; Young Stephen G; Bergo Martin O
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.
The Journal of clinical investigation 2007;117(5):1294-304.
2007: Baron Rudi A; Peterson Yuri K; Otto James C; Rudolph Johannes; Casey Patrick J
Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules.
Biochemistry 2007;46(2):554-60.
2006: Stemmle Laura N; Fields Timothy A; Casey Patrick J
The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13.
Molecular pharmacology 2006;70(4):1461-8.
2006: Kelly Patrick; Stemmle Laura N; Madden John F; Fields Timothy A; Daaka Yehia; Casey Patrick J
A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.
The Journal of biological chemistry 2006;281(36):26483-90.
2006: Terry Kimberly L; Casey Patrick J; Beese Lorena S
Conversion of protein farnesyltransferase to a geranylgeranyltransferase.
Biochemistry 2006;45(32):9746-55.
2006: Kelly Patrick; Moeller Benjamin J; Juneja Juhi; Booden Michelle A; Der Channing J; Daaka Yehia; Dewhirst Mark W; Fields Timothy A; Casey Patrick J
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8173-8.
2006: Peterson Yuri K; Kelly Patrick; Weinbaum Carolyn A; Casey Patrick J
A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.
The Journal of biological chemistry 2006;281(18):12445-50.
2006: Svensson Annika W; Casey Patrick J; Young Stephen G; Bergo Martin O
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.
Methods in enzymology 2006;407():144-59.
2005: Kimple Michelle E; Nixon Andrew B; Kelly Patrick; Bailey Candice L; Young Kenneth H; Fields Timothy A; Casey Patrick J
A role for G(z) in pancreatic islet beta-cell biology.
The Journal of biological chemistry 2005;280(36):31708-13.
2005: Winter-Vann Ann M; Casey Patrick J
Post-prenylation-processing enzymes as new targets in oncogenesis.
Nature reviews. Cancer 2005;5(5):405-12.
2005: Meigs Thomas E; Juneja Juhi; DeMarco C Todd; Stemmle Laura N; Kaplan Daniel D; Casey Patrick J
Selective uncoupling of G alpha 12 from Rho-mediated signaling.
The Journal of biological chemistry 2005;280(18):18049-55.
2005: Winter-Vann Ann M; Baron Rudi A; Wong Waihay; dela Cruz June; York John D; Gooden David M; Bergo Martin O; Young Stephen G; Toone Eric J; Casey Patrick J
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4336-41.
2005: Kasbohm Elizabeth A; Guo Rishu; Yowell Charles W; Bagchi Gargi; Kelly Patrick; Arora Puneeta; Casey Patrick J; Daaka Yehia
Androgen receptor activation by G(s) signaling in prostate cancer cells.
The Journal of biological chemistry 2005;280(12):11583-9.
2004: Baron Rudi A; Casey Patrick J
Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt).
BMC biochemistry 2004;5():19.
2004: Embry Alan C; Glick Jennifer L; Linder Maurine E; Casey Patrick J
Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family.
Molecular pharmacology 2004;66(5):1325-31.
2004: Reid T Scott; Terry Kimberly L; Casey Patrick J; Beese Lorena S
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Journal of molecular biology 2004;343(2):417-33.
2004: Kaplan Daniel D; Meigs Thomas E; Kelly Patrick; Casey Patrick J
Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle.
The Journal of biological chemistry 2004;279(12):10829-32.
2004: Bergo Martin O; Gavino Bryant J; Hong Christine; Beigneux Anne P; McMahon Martin; Casey Patrick J; Young Stephen G
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
The Journal of clinical investigation 2004;113(4):539-50.
2004: Bergo Martin O; Lieu Hsiao D; Gavino Bryant J; Ambroziak Patricia; Otto James C; Casey Patrick J; Walker Quinn M; Young Stephen G
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.
The Journal of biological chemistry 2004;279(6):4729-36.
2004: Nixon Andrew B; Casey Patrick J
Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10.
Methods in enzymology 2004;390():53-64.
2003: Taylor Jeffrey S; Reid T Scott; Terry Kimberly L; Casey Patrick J; Beese Lorena S
Structure of mammalian protein geranylgeranyltransferase type-I.
The EMBO journal 2003;22(22):5963-74.
2003: Pickett Jennifer S; Bowers Katherine E; Hartman Heather L; Fu Hua-Wen; Embry Alan C; Casey Patrick J; Fierke Carol A
Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation.
Biochemistry 2003;42(32):9741-8.
2003: Winter-Vann Ann M; Kamen Barton A; Bergo Martin O; Young Stephen G; Melnyk Stepan; James S Jill; Casey Patrick J
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6529-34.
2002: Meng Jingwei; Casey Patrick J
Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells.
The Journal of biological chemistry 2002;277(45):43417-24.
2002: Long Stephen B; Casey Patrick J; Beese Lorena S
Reaction path of protein farnesyltransferase at atomic resolution.
Nature 2002;419(6907):645-50.
2002: Digits Jennifer A; Pyun Hyung-Jung; Coates Robert M; Casey Patrick J
Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase.
The Journal of biological chemistry 2002;277(43):41086-93.
2002: Beigneux Anne; Withycombe Shannon K; Digits Jennifer A; Tschantz William R; Weinbaum Carolyn A; Griffey Stephen M; Bergo Martin; Casey Patrick J; Young Stephen G
Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver.
The Journal of biological chemistry 2002;277(41):38358-63.
2002: Meigs Thomas E; Fedor-Chaiken Mary; Kaplan Daniel D; Brackenbury Robert; Casey Patrick J
Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.
The Journal of biological chemistry 2002;277(27):24594-600.
2002: Nixon Andrew B; Grenningloh Gabriele; Casey Patrick J
The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
The Journal of biological chemistry 2002;277(20):18127-33.
2002: Bergo Martin O; Ambroziak Patricia; Gregory Cria; George Amanda; Otto James C; Kim Edward; Nagase Hiroki; Casey Patrick J; Balmain Allan; Young Stephen G
Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
Molecular and cellular biology 2002;22(1):171-81.
2001: Hightower K E; De S; Weinbaum C; Spence R A; Casey P J
Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis.
The Biochemical journal 2001;360(Pt 3):625-31.
2001: Kaplan D D; Meigs T E; Casey P J
Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin.
The Journal of biological chemistry 2001;276(47):44037-43.
2001: Burgon P G; Lee W L; Nixon A B; Peralta E G; Casey P J
Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).
The Journal of biological chemistry 2001;276(35):32828-34.
2001: Schlitzer M; Winter-Vann A; Casey P J
Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.
Bioorganic & medicinal chemistry letters 2001;11(3):425-7.
2001: Bergo M O; Leung G K; Ambroziak P; Otto J C; Casey P J; Gomes A Q; Seabra M C; Young S G
Isoprenylcysteine carboxyl methyltransferase deficiency in mice.
The Journal of biological chemistry 2001;276(8):5841-5.
2001: Hightower K E; Casey P J; Fierke C A
Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase.
Biochemistry 2001;40(4):1002-10.
2001: Meigs T E; Fields T A; McKee D D; Casey P J
Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):519-24.
2001: Tschantz W R; Digits J A; Pyun H J; Coates R M; Casey P J
Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase.
The Journal of biological chemistry 2001;276(4):2321-4.
2000: Chen Z; Otto J C; Bergo M O; Young S G; Casey P J
The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules.
The Journal of biological chemistry 2000;275(52):41251-7.
2000: Spence R A; Hightower K E; Terry K L; Beese L S; Fierke C A; Casey P J
Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition.
Biochemistry 2000;39(45):13651-9.
2000: Bergo M O; Leung G K; Ambroziak P; Otto J C; Casey P J; Young S G
Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells.
The Journal of biological chemistry 2000;275(23):17605-10.
2000: Long S B; Casey P J; Beese L S
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure (London, England : 1993) 2000;8(2):209-22.
1999: Meng J; Glick J L; Polakis P; Casey P J
Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk.
The Journal of biological chemistry 1999;274(51):36663-9.
1999: Tschantz W R; Zhang L; Casey P J
Cloning, expression, and cellular localization of a human prenylcysteine lyase.
The Journal of biological chemistry 1999;274(50):35802-8.
1999: Kim E; Ambroziak P; Otto J C; Taylor B; Ashby M; Shannon K; Casey P J; Young S G
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
The Journal of biological chemistry 1999;274(13):8383-90.
1999: Otto J C; Kim E; Young S G; Casey P J
Cloning and characterization of a mammalian prenyl protein-specific protease.
The Journal of biological chemistry 1999;274(13):8379-82.
1999: Fu H W; Casey P J
Enzymology and biology of CaaX protein prenylation.
Recent progress in hormone research 1999;54():315-42; discussion 342-3.
1998: Hightower K E; Huang C C; Casey P J; Fierke C A
H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate.
Biochemistry 1998;37(44):15555-62.
1998: Glick J L; Meigs T E; Miron A; Casey P J
RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.
The Journal of biological chemistry 1998;273(40):26008-13.
1998: Long S B; Casey P J; Beese L S
Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
Biochemistry 1998;37(27):9612-8.
1998: Fu H W; Beese L S; Casey P J
Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase.
Biochemistry 1998;37(13):4465-72.
1997: Thissen J A; Gross J M; Subramanian K; Meyer T; Casey P J
Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.
The Journal of biological chemistry 1997;272(48):30362-70.
1997: Hurwitz L M; Casey P J
Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?
Chemistry & biology 1997;4(10):711-5.
1997: Zhang L; Tschantz W R; Casey P J
Isolation and characterization of a prenylcysteine lyase from bovine brain.
The Journal of biological chemistry 1997;272(37):23354-9.
1997: Tschantz W R; Furfine E S; Casey P J
Substrate binding is required for release of product from mammalian protein farnesyltransferase.
The Journal of biological chemistry 1997;272(15):9989-93.
1997: Park H W; Boduluri S R; Moomaw J F; Casey P J; Beese L S
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.
Science (New York, N.Y.) 1997;275(5307):1800-4.
1997: Fields T A; Casey P J
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.
The Biochemical journal 1997;321 ( Pt 3)():561-71.
1997: Huang C C; Casey P J; Fierke C A
Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate.
The Journal of biological chemistry 1997;272(1):20-3.
1996: Zhang F L; Casey P J
Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I.
The Biochemical journal 1996;320 ( Pt 3)():925-32.
1996: Thissen J A; Casey P J
Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions.
Analytical biochemistry 1996;243(1):80-5.
1996: Fu H W; Moomaw J F; Moomaw C R; Casey P J
Identification of a cysteine residue essential for activity of protein farnesyltransferase. Cys299 is exposed only upon removal of zinc from the enzyme.
The Journal of biological chemistry 1996;271(45):28541-8.
1996: Higgins J B; Casey P J
The role of prenylation in G-protein assembly and function.
Cellular signalling 1996;8(6):433-7.
1996: Zhang F L; Fu H W; Casey P J; Bishop W R
Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity.
Biochemistry 1996;35(25):8166-71.
1996: Casey P J; Seabra M C
Protein prenyltransferases.
The Journal of biological chemistry 1996;271(10):5289-92.
1996: Otto J C; Casey P J
The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells.
The Journal of biological chemistry 1996;271(9):4569-72.
1996: Glick J; Santoyo G; Casey P J
Arachidonate and related unsaturated fatty acids selectively inactivate the guanine nucleotide-binding regulatory protein, Gz.
The Journal of biological chemistry 1996;271(6):2949-54.
1996: Zhang F L; Casey P J
Protein prenylation: molecular mechanisms and functional consequences.
Annual review of biochemistry 1996;65():241-69.
1995: Huang C L; Slesinger P A; Casey P J; Jan Y N; Jan L Y
Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.
Neuron 1995;15(5):1133-43.
1995: Fields T A; Casey P J
Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.
The Journal of biological chemistry 1995;270(39):23119-25.
1995: Zhang L; Sachs C W; Fu H W; Fine R L; Casey P J
Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells.
The Journal of biological chemistry 1995;270(39):22859-65.
1995: Furfine E S; Leban J J; Landavazo A; Moomaw J F; Casey P J
Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release.
Biochemistry 1995;34(20):6857-62.
1995: Casey P J
Protein lipidation in cell signaling.
Science (New York, N.Y.) 1995;268(5208):221-5.
1995: Casey P J
Mechanisms of protein prenylation and role in G protein function.
Biochemical Society transactions 1995;23(1):161-6.
1995: Thissen J A; Barrett M G; Casey P J
Prenylated peptides in identification of specific binding proteins.
Methods in enzymology 1995;250():158-68.
1995: Moomaw J F; Zhang F L; Casey P J
Isolation of protein prenyltransferases from bovine brain and baculovirus expression system.
Methods in enzymology 1995;250():12-21.
1994: Zhang F L; Moomaw J F; Casey P J
Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I.
The Journal of biological chemistry 1994;269(38):23465-70.
1994: Fields T A; Linder M E; Casey P J
Subtype-specific binding of azidoanilido-GTP by purified G protein alpha subunits.
Biochemistry 1994;33(22):6877-83.
1994: Zhang L; Sachs C W; Fine R L; Casey P J
Interaction of prenylcysteine methyl esters with the multidrug resistance transporter.
The Journal of biological chemistry 1994;269(23):15973-6.
1994: Casey P J
Lipid modifications of G proteins.
Current opinion in cell biology 1994;6(2):219-25.
1994: Higgins J B; Casey P J
In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex.
The Journal of biological chemistry 1994;269(12):9067-73.
1994: Zhang F L; Diehl R E; Kohl N E; Gibbs J B; Giros B; Casey P J; Omer C A
cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.
The Journal of biological chemistry 1994;269(5):3175-80.
1994: Casey P J; Moomaw J F; Zhang F L; Higgins Y B; Thissen J A
Prenylation and G protein signaling.
Recent progress in hormone research 1994;49():215-38.
1993: Thissen J A; Casey P J
Microsomal membranes contain a high affinity binding site for prenylated peptides.
The Journal of biological chemistry 1993;268(19):13780-3.
1993: Chen W J; Moomaw J F; Overton L; Kost T A; Casey P J
High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc.
The Journal of biological chemistry 1993;268(13):9675-80.
1992: Casey P J
Biochemistry of protein prenylation.
Journal of lipid research 1992;33(12):1731-40.
1992: Moomaw J F; Casey P J
Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements.
The Journal of biological chemistry 1992;267(24):17438-43.
1992: Pitcher J A; Inglese J; Higgins J B; Arriza J L; Casey P J; Kim C; Benovic J L; Kwatra M M; Caron M G; Lefkowitz R J
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.
Science (New York, N.Y.) 1992;257(5074):1264-7.
1992: Ménard L; Tomhave E; Casey P J; Uhing R J; Snyderman R; Didsbury J R
Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties.
European journal of biochemistry / FEBS 1992;206(2):537-46.
1991: Casey P J; Thissen J A; Moomaw J F
Enzymatic modification of proteins with a geranylgeranyl isoprenoid.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8631-5.

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