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John Clements

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Chemicals & Drugs

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Immunity, Mucosal

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Rotavirus Infections

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Elizabeth B Norton; Lucy C Freytag; Louise B Lawson; Zaid Mahdi; John Clements
The A subunit of Escherichia coli heat-labile enterotoxin functions as a mucosal adjuvant and promotes IgG2a, IgA, and Th17 responses to vaccine antigens.
L B Lawson; John Clements; Lucy C Freytag
Mucosal immune responses induced by transcutaneous vaccines.
Elizabeth B Norton; Louise B Lawson; Lucy C Freytag; John Clements
Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.

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All Publications

2012: Elizabeth B Norton; Lucy C Freytag; Louise B Lawson; Zaid Mahdi; John Clements
The A subunit of Escherichia coli heat-labile enterotoxin functions as a mucosal adjuvant and promotes IgG2a, IgA, and Th17 responses to vaccine antigens.
Infection and immunity 2012;80(7):2426-35.
2012: L B Lawson; John Clements; Lucy C Freytag
Mucosal immune responses induced by transcutaneous vaccines.
Current topics in microbiology and immunology 2012;354():19-37.
2011: Elizabeth B Norton; Louise B Lawson; Lucy C Freytag; John Clements
Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.
Clinical and vaccine immunology : CVI 2011;18(4):546-51.
2010: Sangun Lee; Boris R Belitsky; James P Brinker; Kathryn O Kerstein; David W Brown; John Clements; Gerald T Keusch; Saul Tzipori; Abraham L Sonenshein; John E Herrmann
Development of a Bacillus subtilis-based rotavirus vaccine.
Clinical and vaccine immunology : CVI 2010;17(11):1647-55.
2010: Ying-Jie Lu; Puja Yadav; John Clements; Sophie Forte; Amit Srivastava; Claudette M Thompson; Robert Seid; Jee Look; Mark Alderson; Andrea Tate; Jean-François Maisonneuve; George Robertson; Porter W Anderson; Richard Malley
Options for inactivation, adjuvant, and route of topical administration of a killed, unencapsulated pneumococcal whole-cell vaccine.
Clinical and vaccine immunology : CVI 2010;17(6):1005-12.
2010: David R Tribble; Shahida Baqar; Daniel A Scott; Michael L Oplinger; Fernando Trespalacios; David Rollins; Richard I Walker; John Clements; Steven Walz; Paul Gibbs; Edward F Burg; Anthony P Moran; Lisa Applebee; A Louis Bourgeois
Assessment of the duration of protection in Campylobacter jejuni experimental infection in humans.
Infection and immunity 2010;78(4):1750-9.
2010: Elizabeth B Norton; John Clements; Thomas G Voss; L Cárdenas-Freytag
Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model.
Journal of virology 2010;84(6):2983-95.
2010: Nancy A Summerton; Richard W Welch; Laureano Bondoc; Huei-Hsiung Yang; Brett Pleune; Naryaswamy Ramachandran; Andrea M Harris; Desiree Bland; W James Jackson; Sukjoon Park; John Clements; Gary Nabors
Toward the development of a stable, freeze-dried formulation of Helicobacter pylori killed whole cell vaccine adjuvanted with a novel mutant of Escherichia coli heat-labile toxin.
Vaccine 2010;28(5):1404-11.
2010: Grace Tan; Peng Xu; Louise B Lawson; Jibao He; Lucy C Freytag; John Clements; Vijay T John
Hydration effects on skin microstructure as probed by high-resolution cryo-scanning electron microscopy and mechanistic implications to enhanced transcutaneous delivery of biomacromolecules.
Journal of pharmaceutical sciences 2010;99(2):730-40.
2009: Fu-Shi Quan; Dae Goon Yoo; Jae-Min Song; John Clements; Richard W Compans; Sang-Moo Kang
Kinetics of immune responses to influenza virus-like particles and dose-dependence of protection with a single vaccination.
Journal of virology 2009;83(9):4489-97.
2007: Frank Verdonck; P Tiels; K van Gog; Bruno Goddeeris; N Lycke; John Clements; Eric Cox
Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18+ Escherichia coli infection.
Veterinary immunology and immunopathology 2007;120(3-4):69-79.
2007: Monica M McNeal; Susan C Stone; Mitali Basu; John Clements; Anthony H-C Choi; Richard L Ward
IFN-gamma is the only anti-rotavirus cytokine found after in vitro stimulation of memory CD4+ T cells from mice immunized with a chimeric VP6 protein.
Viral immunology 2007;20(4):571-84.
2007: L B Lawson; Lucy C Freytag; John Clements
Use of nanocarriers for transdermal vaccine delivery.
Clinical pharmacology and therapeutics 2007;82(6):641-3.
2007: Sabena Uddowla; Lucy C Freytag; John Clements
Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens.
Vaccine 2007;25(47):7984-93.
2007: Monica M McNeal; Mitali Basu; Judy A Bean; John Clements; Nils Lycke; Anna Ramne; Björn Löwenadler; Anthony H-C Choi; Richard L Ward
Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge.
Vaccine 2007;25(33):6224-31.
2007: Monica M McNeal; Mitali Basu; Judy A Bean; John Clements; Anthony H-C Choi; Richard L Ward
Identification of an immunodominant CD4+ T cell epitope in the VP6 protein of rotavirus following intranasal immunization of BALB/c mice.
Virology 2007;363(2):410-8.
2007: Amanda B DuBois; Lucy C Freytag; John Clements
Evaluation of combinatorial vaccines against anthrax and plague in a murine model.
Vaccine 2007;25(24):4747-54.
2007: Anthony H-C Choi; Kristi L Smiley; Mitali Basu; Monica M McNeal; Mingyuan Shao; Judy A Bean; John Clements; Richard R Stout; Richard L Ward
Protection of mice against rotavirus challenge following intradermal DNA immunization by Biojector needle-free injection.
Vaccine 2007;25(16):3215-8.
2007: Kristi L Smiley; Monica M McNeal; Mitali Basu; Anthony H-C Choi; John Clements; Richard L Ward
Association of gamma interferon and interleukin-17 production in intestinal CD4+ T cells with protection against rotavirus shedding in mice intranasally immunized with VP6 and the adjuvant LT(R192G).
Journal of virology 2007;81(8):3740-8.
2006: Bapi Pahar; Mayra A Cantu; Wei Zhao; Marcelo J Kuroda; Ronald S Veazey; David C Montefiori; John Clements; Pyone Aye; Andrew Lackner; Karin Lovgren-Bengtsson; Karol Sestak
Single epitope mucosal vaccine delivered via immuno-stimulating complexes induces low level of immunity against simian-HIV.
Vaccine 2006;24(47-48):6839-49.
2006: John L VanCott; Anne E Prada; Monica M McNeal; Susan C Stone; Mitali Basu; Bert Huffer; Kristi L Smiley; Mingyuan Shao; Judy A Bean; John Clements; Anthony H-C Choi; Richard L Ward
Mice develop effective but delayed protective immune responses when immunized as neonates either intranasally with nonliving VP6/LT(R192G) or orally with live rhesus rotavirus vaccine candidates.
Journal of virology 2006;80(10):4949-61.
2006: Igor M Belyakov; Vladimir Kuznetsov; Brian Kelsall; Dennis M Klinman; Marcin Moniuszko; Michael Lemon; Phillip D Markham; Ranajit Pal; John Clements; Mark G Lewis; Warren Strober; Genoveffa Franchini; Jay A Berzofsky
Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa.
Blood 2006;107(8):3258-64.
2006: Monica M McNeal; Susan C Stone; Mitali Basu; Judy A Bean; John Clements; Barbara A Hendrickson; Anthony H-C Choi; Richard L Ward
Protection against rotavirus shedding after intranasal immunization of mice with a chimeric VP6 protein does not require intestinal IgA.
Virology 2006;346(2):338-47.
2005: Ping Zhang; Qiu-Bo Yang; Daniel F Balkovetz; Janina P Lewis; John Clements; Suzanne M Michalek; Jannet Katz
Effectiveness of the B subunit of cholera toxin in potentiating immune responses to the recombinant hemagglutinin/adhesin domain of the gingipain Kgp from Porphyromonas gingivalis.
Vaccine 2005;23(39):4734-44.
2005: Audrey Glynn; Chad J Roy; Bradford S Powell; Jeffrey J Adamovicz; Lucy C Freytag; John Clements
Protection against aerosolized Yersinia pestis challenge following homologous and heterologous prime-boost with recombinant plague antigens.
Infection and immunity 2005;73(8):5256-61.
2005: Audrey Glynn; Lucy C Freytag; John Clements
Effect of homologous and heterologous prime-boost on the immune response to recombinant plague antigens.
Vaccine 2005;23(16):1957-65.
2005: Lucy C Freytag; John Clements
Mucosal adjuvants.
Vaccine 2005;23(15):1804-13.
2005: Sarah Leavell; Brittany Wright; Lori Scappino; Jamal Sirriyah; Chang Chen; John Clements; Mary Jo Burkhard
Induction of serum and mucosal FIV-specific immune responses by intranasal immunization with p24Gag.
Vaccine 2005;23(12):1471-8.
2004: Anthony H-C Choi; Mitali Basu; Monica M McNeal; Judy A Bean; John Clements; Richard L Ward
Intranasal administration of an Escherichia coli-expressed codon-optimized rotavirus VP6 protein induces protection in mice.
Protein expression and purification 2004;38(2):205-16.
2003: Ping Zhang; Qiu-Bo Yang; Dante J Marciani; Michael Martin; John Clements; Suzanne M Michalek; Jannet Katz
Effectiveness of the quillaja saponin semi-synthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalis.
Vaccine 2003;21(27-30):4459-71.
2003: Cynthia A Lemere; Edward T Spooner; John LaFrancois; Brian Malester; Chica Mori; Jodi F Leverone; Yasuji Matsuoka; Jennie W Taylor; Ronald B DeMattos; David M Holtzman; John Clements; Dennis J Selkoe; karen duff
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Neurobiology of disease 2003;14(1):10-8.
2003: Heribert Warzecha; Hugh S Mason; Christopher Lane; Anders Tryggvesson; Edward Rybicki; Anna-Lise Williamson; John Clements; Robert C Rose
Oral immunogenicity of human papillomavirus-like particles expressed in potato.
Journal of virology 2003;77(16):8702-11.
2003: Jodi F Leverone; Edward T Spooner; Herman Lehman; John Clements; Cynthia A Lemere
Abeta1-15 is less immunogenic than Abeta1-40/42 for intranasal immunization of wild-type mice but may be effective for "boosting".
Vaccine 2003;21(17-18):2197-206.
2003: Zandrea Ambrose; Jannelle Thompson; Kay Larsen; Larene Kuller; Dennis Panicali; John Clements; Michael B Agy; David C Montefiori; Shiu-Lok Hu; Marnix Bosch
Evidence for immune-mediated reduction of viral replication in Macaca nemestrina mucosally immunized with inactivated SHIV(89.6).
Virology 2003;308(1):178-90.
2003: Anthony H-C Choi; Monica M McNeal; Mitali Basu; Judy A Bean; John L VanCott; John Clements; Richard L Ward
Functional mapping of protective epitopes within the rotavirus VP6 protein in mice belonging to different haplotypes.
Vaccine 2003;21(7-8):761-7.
2002: Cynthia A Lemere; Edward T Spooner; Jodi F Leverone; Chica Mori; John Clements
Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants.
Neurobiology of aging 2002;23(6):991-1000.
2002: Anthony H-C Choi; Monica M McNeal; Mitali Basu; Jason A Flint; Susan C Stone; John Clements; Judy A Bean; Stacy A Poe; John L VanCott; Richard L Ward
Intranasal or oral immunization of inbred and outbred mice with murine or human rotavirus VP6 proteins protects against viral shedding after challenge with murine rotaviruses.
Vaccine 2002;20(27-28):3310-21.
2002: Michael Martin; Arlene Sharpe; John Clements; Suzanne M Michalek
Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):1744-52.
2002: L Cárdenas-Freytag; Chad Steele; Floyd L Wormley; E Cheng; John Clements; Paul L Fidel
Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed Candida albicans and the mucosal adjuvant LT(R192G).
Medical mycology : official publication of the International Society for Human and Animal Mycology 2002;40(3):291-9.
2002: Anthony H-C Choi; Monica M McNeal; Jason A Flint; Mitali Basu; Nils Lycke; John Clements; Judy A Bean; Heather L Davis; Michael J McCluskie; John L VanCott; Richard L Ward
The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant.
Vaccine 2002;20(13-14):1733-40.
2002: Xiuhua Lu; John Clements; Jacqueline M Katz
Mutant Escherichia coli heat-labile enterotoxin [LT(R192G)] enhances protective humoral and cellular immune responses to orally administered inactivated influenza vaccine.
Vaccine 2002;20(7-8):1019-29.
2002: Monica M McNeal; John L VanCott; Anthony H-C Choi; Mitali Basu; Jason A Flint; Susan C Stone; John Clements; Richard L Ward
CD4 T cells are the only lymphocytes needed to protect mice against rotavirus shedding after intranasal immunization with a chimeric VP6 protein and the adjuvant LT(R192G).
Journal of virology 2002;76(2):560-8.
2001: Igor M Belyakov; Zdenek Hel; Brian Kelsall; Vladimir Kuznetsov; Jeffrey D Ahlers; Janos Nacsa; David Ian Watkins; Todd M Allen; A Sette; John D Altman; ruth woodward; Phillip D Markham; John Clements; Genoveffa Franchini; Warren Strober; Jay A Berzofsky
Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques.
Nature medicine 2001;7(12):1320-6.
2001: Cindy B Morris; A Thanawastien; Deborah E Sullivan; John Clements
Identification of a peptide capable of inducing an HIV-1 Tat-specific CTL response.
Vaccine 2001;20(1-2):12-5.
2001: RA Guerrero; JM Ball; S S Krater; Susan E Pacheco; John Clements; Mary K Estes
Recombinant Norwalk virus-like particles administered intranasally to mice induce systemic and mucosal (fecal and vaginal) immune responses.
Journal of virology 2001;75(20):9713-22.
2001: Michael J McCluskie; Risini D Weeratna; John Clements; Heather L Davis
Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants.
Vaccine 2001;19(27):3759-68.
2001: Terrence M Tumpey; Mary Renshaw; John Clements; Jacqueline M Katz
Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infection.
Journal of virology 2001;75(11):5141-50.
2001: S Gerber; Christopher Lane; D M Brown; E Lord; M DiLorenzo; John Clements; Edward Rybicki; Anna-Lise Williamson; Robert C Rose
Human papillomavirus virus-like particles are efficient oral immunogens when coadministered with Escherichia coli heat-labile enterotoxin mutant R192G or CpG DNA.
Journal of virology 2001;75(10):4752-60.
2001: C C Bowman; John Clements
Differential biological and adjuvant activities of cholera toxin and Escherichia coli heat-labile enterotoxin hybrids.
Infection and immunity 2001;69(3):1528-35.
2000: Anthony H-C Choi; Mitali Basu; Monica M McNeal; J Flint; John L VanCott; John Clements; Richard L Ward
Functional mapping of protective domains and epitopes in the rotavirus VP6 protein.
Journal of virology 2000;74(24):11574-80.
2000: Igor M Belyakov; Jeffrey D Ahlers; John Clements; Warren Strober; Jay A Berzofsky
Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6454-62.
2000: HC Guillobel; J I Carinhanha; L Cárdenas; John Clements; DF de Almeida; Luís C S Ferreira
Adjuvant activity of a nontoxic mutant of Escherichia coli heat-labile enterotoxin on systemic and mucosal immune responses elicited against a heterologous antigen carried by a live Salmonella enterica serovar Typhimurium vaccine strain.
Infection and immunity 2000;68(7):4349-53.
2000: Cindy B Morris; E Cheng; A Thanawastien; L Cárdenas-Freytag; John Clements
Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G).
Vaccine 2000;18(18):1944-51.
1999: Anthony H-C Choi; Mitali Basu; Monica M McNeal; John Clements; Richard L Ward
Antibody-independent protection against rotavirus infection of mice stimulated by intranasal immunization with chimeric VP4 or VP6 protein.
Journal of virology 1999;73(9):7574-81.
1999: E Cheng; L Cárdenas-Freytag; John Clements
The role of cAMP in mucosal adjuvanticity of Escherichia coli heat-labile enterotoxin (LT).
Vaccine 1999;18(1-2):38-49.
1999: Edward T Ryan; TI Crean; Manohar John; Joan R Butterton; John Clements; Stephen B Calderwood
In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae.
Infection and immunity 1999;67(4):1694-701.
1999: L Cárdenas-Freytag; E Cheng; P Mayeux; JE Domer; John Clements
Effectiveness of a vaccine composed of heat-killed Candida albicans and a novel mucosal adjuvant, LT(R192G), against systemic candidiasis.
Infection and immunity 1999;67(2):826-33.
1999: Lucy C Freytag; John Clements
Bacterial toxins as mucosal adjuvants.
Current topics in microbiology and immunology 1999;236():215-36.
1998: Hugh S Mason; Tariq Haq; John Clements; Charles J Arntzen
Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene.
Vaccine 1998;16(13):1336-43.
1998: Carol O Tacket; Hugh S Mason; Genevieve A Losonsky; John Clements; Myron M Levine; Charles J Arntzen
Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato.
Nature medicine 1998;4(5):607-9.
1998: C Chong; M Friberg; John Clements
LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp.
Vaccine 1998;16(7):732-40.
1998: Christine M O'Neal; John Clements; Mary K Estes; Margaret E Conner
Rotavirus 2/6 viruslike particles administered intranasally with cholera toxin, Escherichia coli heat-labile toxin (LT), and LT-R192G induce protection from rotavirus challenge.
Journal of virology 1998;72(4):3390-3.
1997: Jesse Guidry; L Cárdenas; E Cheng; John Clements
Role of receptor binding in toxicity, immunogenicity, and adjuvanticity of Escherichia coli heat-labile enterotoxin.
Infection and immunity 1997;65(12):4943-50.
1997: Kenneth L Bost; John Clements
Intracellular Salmonella dublin induces substantial secretion of the 40-kilodalton subunit of interleukin-12 (IL-12) but minimal secretion of IL-12 as a 70-kilodalton protein in murine macrophages.
Infection and immunity 1997;65(8):3186-92.
1997: John Clements
Surface warfare against pathogens using mucosal vaccines.
Nature biotechnology 1997;15(7):622-3.
1997: Kenneth L Bost; C F Hellner; R H Holton; Marion S Ratterree; John Clements; Donald J Krogstad; T Kincy-Cain
Reverse transcriptase-polymerase chain reaction amplification and partial sequence of T helper 1- and T helper 2-type lymphokine genes from the owl monkey (Aotus trivirgatus).
The American journal of tropical medicine and hygiene 1997;56(3):351-8.
1997: CS Toebe; John Clements; L Cardenas; GJ Jennings; Mark F Wiser
Evaluation of immunogenicity of an oral Salmonella vaccine expressing recombinant Plasmodium berghei merozoite surface protein-1.
The American journal of tropical medicine and hygiene 1997;56(2):192-9.
1996: Kenneth L Bost; R H Holton; T K Cain; John Clements
In vivo treatment with anti-interleukin-13 antibodies significantly reduces the humoral immune response against an oral immunogen in mice.
Immunology 1996;87(4):633-41.
1996: T Kincy-Cain; John Clements; Kenneth L Bost
Endogenous and exogenous interleukin-12 augment the protective immune response in mice orally challenged with Salmonella dublin.
Infection and immunity 1996;64(4):1437-40.
1996: I Takahashi; Hiroshi Kiyono; Raymond J Jackson; Kohtaro Fujihashi; H F Staats; S Hamada; John Clements; Kenneth L Bost; Jerry R McGhee
Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.
Infection and immunity 1996;64(4):1290-8.
1996: C Chong; Kenneth L Bost; John Clements
Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp.
Infection and immunity 1996;64(4):1154-60.
1996: I Takahashi; M Marinaro; Hiroshi Kiyono; Raymond J Jackson; I Nakagawa; Kohtaro Fujihashi; S Hamada; John Clements; Kenneth L Bost; Jerry R McGhee
Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin.
The Journal of infectious diseases 1996;173(3):627-35.
1995: Tariq Haq; Hugh S Mason; John Clements; Charles J Arntzen
Oral immunization with a recombinant bacterial antigen produced in transgenic plants.
Science (New York, N.Y.) 1995;268(5211):714-6.
1995: B L Dickinson; John Clements
Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity.
Infection and immunity 1995;63(5):1617-23.
1995: Kenneth L Bost; John Clements
In vivo induction of interleukin-12 mRNA expression after oral immunization with Salmonella dublin or the B subunit of Escherichia coli heat-labile enterotoxin.
Infection and immunity 1995;63(3):1076-83.
1995: I Takahashi; I Nakagawa; H Kiyono; J R McGhee; John Clements; Shigeyuki Hamada
Mucosal T cells induce systemic anergy for oral tolerance.
Biochemical and biophysical research communications 1995;206(1):414-20.
1994: Shousun Chen Szu; David N Taylor; A C Trofa; John Clements; Joseph Shiloach; J C Sadoff; Dolores A Bryla; John B Robbins
Laboratory and preliminary clinical characterization of Vi capsular polysaccharide-protein conjugate vaccines.
Infection and immunity 1994;62(10):4440-4.
1994: L Cárdenas; U Dasgupta; John Clements
Influence of strain viability and antigen dose on the use of attenuated mutants of Salmonella as vaccine carriers.
Vaccine 1994;12(9):833-40.
1993: L Cárdenas; John Clements
Development of mucosal protection against the heat-stable enterotoxin (ST) of Escherichia coli by oral immunization with a genetic fusion delivered by a bacterial vector.
Infection and immunity 1993;61(11):4629-36.
1993: Florence M Rollwagen; ND Pacheco; John Clements; O Pavlovskis; D M Rollins; R I Walker
Killed Campylobacter elicits immune response and protection when administered with an oral adjuvant.
Vaccine 1993;11(13):1316-20.
1993: L Cárdenas; John Clements
Stability, immunogenicity and expression of foreign antigens in bacterial vaccine vectors.
Vaccine 1993;11(2):126-35.
1992: L Cárdenas; John Clements
Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens.
Clinical microbiology reviews 1992;5(3):328-42.
1991: J X Bao; John Clements
Prior immunologic experience potentiates the subsequent antibody response when Salmonella strains are used as vaccine carriers.
Infection and immunity 1991;59(10):3841-5.
1990: John Clements; L Cárdenas
Vaccines against enterotoxigenic bacterial pathogens based on hybrid Salmonella that express heterologous antigens.
Research in microbiology 1990;141(7-8):981-93.
1990: John Clements
Construction of a nontoxic fusion peptide for immunization against Escherichia coli strains that produce heat-labile and heat-stable enterotoxins.
Infection and immunity 1990;58(5):1159-66.
1989: D F Sigwart; B A Stocker; John Clements
Effect of a purA mutation on efficacy of Salmonella live-vaccine vectors.
Infection and immunity 1989;57(6):1858-61.
1988: John Clements; N M Hartzog; F L Lyon
Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens.
Vaccine 1988;6(3):269-77.
1987: John Clements
Use of attenuated mutants of Salmonella as carriers for delivery of heterologous antigens to the secretory immune system.
Pathology and immunopathology research 1987;6(2):137-46.
1986: Carl R Alving; Roberta L Richards; J Moss; L I Alving; John Clements; T Shiba; S Kotani; R A Wirtz; W T Hockmeyer
Effectiveness of liposomes as potential carriers of vaccines: applications to cholera toxin and human malaria sporozoite antigen.
Vaccine 1986;4(3):166-72.
1986: John Clements; F L Lyon; K L Lowe; A L Farrand; S el-Morshidy
Oral immunization of mice with attenuated Salmonella enteritidis containing a recombinant plasmid which codes for production of the B subunit of heat-labile Escherichia coli enterotoxin.
Infection and immunity 1986;53(3):685-92.
1985: John Clements; K L Lowe; L Bonham; S el-Morshidy
Intracellular distribution of heat-labile enterotoxin in a clinical isolate of Escherichia coli.
Infection and immunity 1985;50(1):317-9.
1984: John Clements; S El-Morshidy
Construction of a potential live oral bivalent vaccine for typhoid fever and cholera-Escherichia coli-related diarrheas.
Infection and immunity 1984;46(2):564-9.
1984: F A Klipstein; R F Engert; John Clements; R A Houghten
Differences in cross-protection in rats immunized with the B subunits of cholera toxin and Escherichia coli heat-labile toxin.
Infection and immunity 1984;43(3):811-6.
1983: F A Klipstein; R F Engert; John Clements; R A Houghten
Protection against human and porcine enterotoxigenic strains of Escherichia coli in rats immunized with a cross-linked toxoid vaccine.
Infection and immunity 1983;40(3):924-9.
1983: John Clements; D C Flint; R F Engert; F A Klipstein
Cloning and molecular characterization of the B subunit of Escherichia coli heat-labile enterotoxin.
Infection and immunity 1983;40(2):653-8.
1983: F A Klipstein; R F Engert; John Clements; R A Houghten
Vaccine for enterotoxigenic Escherichia coli based on synthetic heat-stable toxin crossed-linked to the B subunit of heat-labile toxin.
The Journal of infectious diseases 1983;147(2):318-26.
1982: John Clements; D C Flint; F A Klipstein
Immunological and physicochemical characterization of heat-labile enterotoxins isolated from two strains of Escherichia coli.
Infection and immunity 1982;38(2):806-9.
1982: F A Klipstein; R F Engert; John Clements
Arousal of mucosal secretory immunoglobulin A antitoxin in rats immunized with Escherichia coli heat-labile enterotoxin.
Infection and immunity 1982;37(3):1086-92.
1982: F A Klipstein; R F Engert; John Clements
Development of a vaccine of cross-linked heat-stable and heat-labile enterotoxins that protects against Escherichia coli producing either enterotoxin.
Infection and immunity 1982;37(2):550-7.
1982: John Clements
Computer leasing investments provide two-income families inflation hedge, added revenue.
Nephrology nurse 1982;4(3):34-5.
1981: F A Klipstein; R F Engert; John Clements
Protection in rats immunized with Escherichia coli heat-stable enterotoxin.
Infection and immunity 1981;34(2):637-9.
1981: D M Gill; John Clements; D C Robertson; R A Finkelstein
Subunit number and arrangement in Escherichia coli heat-labile enterotoxin.
Infection and immunity 1981;33(3):677-82.
1981: F A Klipstein; R F Engert; John Clements
Immunization of rats with heat-labile enterotoxin provides uniform protection against heterologous serotypes of enterotoxigenic Escherichia coli.
Infection and immunity 1981;32(3):1100-4.
1980: John Clements; R J Yancey; R A Finkelstein
Properties of homogeneous heat-labile enterotoxin from Escherichia coli.
Infection and immunity 1980;29(1):91-7.
1980: Carl R Alving; B Banerji; T Shiba; S Kotani; John Clements; Roberta L Richards
Liposomes as vehicles for vaccines.
Progress in clinical and biological research 1980;47():339-55.
1979: John Clements; R A Finkelstein
Isolation and characterization of homogeneous heat-labile enterotoxins with high specific activity from Escherichia coli cultures.
Infection and immunity 1979;24(3):760-9.
1978: John Clements; R A Finkelstein
Demonstration of shared and unique immunological determinants in enterotoxins from Vibrio cholerae and Escherichia coli.
Infection and immunity 1978;22(3):709-13.
1978: John Clements; R A Finkelstein
Immunological cross-reactivity between a heat-labile enterotoxin(s) of Escherichia coli and subunits of Vibrio cholerae enterotoxin.
Infection and immunity 1978;21(3):1036-9.
1976: E T Nelson; John Clements; R A Finkelstein
Vibrio cholerae adherence and colonization in experimental cholera: electron microscopic studies.
Infection and immunity 1976;14(2):527-47.